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Shiu-Lok Hu

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CD4-Positive T-Lymphocytes

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Miklos Guttman; Shiu-Lok Hu; Maria Kahn; Natalie K Garcia; Kelly K Lee
Solution structure, conformational dynamics, and CD4-induced activation in full-length, glycosylated, monomeric HIV gp120.
Kiran D Mir; Guido Silvestri; Steven E Bosinger; Jason M Brenchley; James ELSE; Melanie Gasper; On Ho; Shiu-Lok Hu; David J Kelvin; Donald L Sodora
Simian immunodeficiency virus-induced alterations in monocyte production of tumor necrosis factor alpha contribute to reduced immune activation in sooty mangabeys.
Xiangming Li; Patricia Polacino; Raquel Garcia-Navarro; Shiu-Lok Hu; Moriya Tsuji
Peripheral blood invariant natural killer T cells of pig-tailed macaques.

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All Publications

2012: Miklos Guttman; Shiu-Lok Hu; Maria Kahn; Natalie K Garcia; Kelly K Lee
Solution structure, conformational dynamics, and CD4-induced activation in full-length, glycosylated, monomeric HIV gp120.
Journal of virology 2012;86(16):8750-64.
2012: Kiran D Mir; Guido Silvestri; Steven E Bosinger; Jason M Brenchley; James ELSE; Melanie Gasper; On Ho; Shiu-Lok Hu; David J Kelvin; Donald L Sodora
Simian immunodeficiency virus-induced alterations in monocyte production of tumor necrosis factor alpha contribute to reduced immune activation in sooty mangabeys.
Journal of virology 2012;86(14):7605-15.
2012: Xiangming Li; Patricia Polacino; Raquel Garcia-Navarro; Shiu-Lok Hu; Moriya Tsuji
Peripheral blood invariant natural killer T cells of pig-tailed macaques.
PloS one 2012;7(10):e48166.
2012: Anton M Sholukh; Hemant K Vyas; Jennifer D Watkins; Peter H Schur; Vivekanandan Shanmuganathan; Sosthène S Essono; Girish Hemashettar; Shiu-Lok Hu; Michael Humbert; Maria Kahn; David C Montefiori; Muhammad M Mukhtar; Victoria R Polonis; Ruth M Ruprecht
Isolation of monoclonal antibodies with predetermined conformational epitope specificity.
PloS one 2012;7(6):e38943.
2012: For Yue Tso; Damien Tully; Sandra Gonzalez; On Ho; Shiu-Lok Hu; Patricia Polacino; Christopher Quince; Ruth Ruprecht; Charles Wood
Dynamics of envelope evolution in clade C SHIV-infected pig-tailed macaques during disease progression analyzed by ultra-deep pyrosequencing.
PloS one 2012;7(3):e32827.
2011: Elizabeth A Dietrich; Betsy Ferguson; David O'Connor; Roger W Wiseman; Greg Brennan; Shiu-Lok Hu
Variable prevalence and functional diversity of the antiretroviral restriction factor TRIMCyp in Macaca fascicularis.
Journal of virology 2011;85(19):9956-63.
2011: Samir K Lakhashe; Sandra J Lee; Sufen Li; Zhongxia Li; Judy Lieberman; David C Montefiori; Francis J Novembre; Robert A Rasmussen; Marjorie Robert-Guroff; Rama Rao Amara; Janet M Dipasquale; Fred R Frankel; Girish Hemashettar; Shiu-Lok Hu; Welkin E Johnson; Maria Kahn; Gaia Sciaranghella; Nagadenahalli B Siddappa; Vijayakumar Velu; Francios VILLINGER; Feng Yang; John K Yoon; Ruth Ruprecht
Prime-boost vaccination with heterologous live vectors encoding SIV gag and multimeric HIV-1 gp160 protein: efficacy against repeated mucosal R5 clade C SHIV challenges.
Vaccine 2011;29(34):5611-22.
2011: Rajesh Thippeshappa; Patricia Polacino; Monica T Yu Kimata; Edward B Siwak; David Anderson; Weiming Wang; Laura Sherwood; Reetakshi Arora; Michael Wen; Paul Zhou; Shiu-Lok Hu; Jason T Kimata
Vif substitution enables persistent infection of pig-tailed macaques by human immunodeficiency virus type 1.
Journal of virology 2011;85(8):3767-79.
2011: Samir K Lakhashe; Sandra J Lee; David C Montefiori; Francis J Novembre; Patricia Polacino; Ruth Ruprecht; Nagadenahalli B Siddappa; Francios VILLINGER; Wendy Wang; John K Yoon; James ELSE; Girish Hemashettar; Shiu-Lok Hu; Robert A Rasmussen
Vaccination against heterologous R5 clade C SHIV: prevention of infection and correlates of protection.
PloS one 2011;6(7):e22010.
2011: Michael Santosuosso; Elda Righi; E David Hill; Pierre R Leblanc; Brett Kodish; Hari N Mylvaganam; Nagadenahalli B Siddappa; Liljana Stevceva; Shiu-Lok Hu; Musie Ghebremichael; Agnes-L Chenine; Avi-Hai Hovav; Ruth Ruprecht; Mark C Poznansky
R5-SHIV induces multiple defects in T cell function during early infection of rhesus macaques including accumulation of T reg cells in lymph nodes.
PloS one 2011;6(4):e18465.
2011: Mary Kearney; Jon Spindler; Wei Shao; Frank Maldarelli; Sarah Palmer; Shiu-Lok Hu; Jeffrey D Lifson; Vineet N KewalRamani; John W Mellors; John M Coffin; Zandrea Ambrose
Genetic diversity of simian immunodeficiency virus encoding HIV-1 reverse transcriptase persists in macaques despite antiretroviral therapy.
Journal of virology 2011;85(2):1067-76.
2010: Catherine A Blish; D Noah Sather; George Sellhorn; Leonidas Stamatatos; Yide Sun; Indresh Srivastava; Susan W Barnett; Brad Cleveland; Julie Overbaugh; Shiu-Lok Hu
Comparative immunogenicity of subtype a Human Immunodeficiency Virus type 1 envelope exhibiting differential exposure of conserved neutralization epitopes.
Journal of virology 2010;84(5):2573-84.
2010: Elizabeth A Dietrich; Lisa Jones-Engel; Shiu-Lok Hu
Evolution of the antiretroviral restriction factor TRIMCyp in Old World primates.
PloS one 2010;5(11):e14019.
2009: On Ho; Kay Larsen; Patricia Polacino; Yun Li; David Anderson; Ruijiang Song; Ruth Ruprecht; Shiu-Lok Hu
Pathogenic infection of Macaca nemestrina with a CCR5-tropic subtype-C simian-human immunodeficiency virus.
Retrovirology 2009;6():65.
2008: Patricia Polacino; Kay Larsen; Lindsey Galmin; John Suschak; Zane Kraft; Leonidas Stamatatos; David Anderson; Susan W Barnett; Ranajit Pal; Kristen Bost; A H Bandivdekar; Christopher J Miller; Shiu-Lok Hu
Differential pathogenicity of SHIV infection in pig-tailed and rhesus macaques.
Journal of medical primatology 2008;37 Suppl 2():13-23.
2008: Cecilia Morgan; Marta Marthas; Christopher J Miller; Ann Duerr; Cecilia Cheng-Mayer; Ronald Desrosiers; Jorge Flores; Nancy Haigwood; Shiu-Lok Hu; R Paul Johnson; Jeffrey Lifson; David Montefiori; John Moore; Marjorie Robert-Guroff; Harriet Robinson; Steven Self; Lawrence Corey
The use of nonhuman primate models in HIV vaccine development.
PLoS medicine 2008;5(8):e173.
2008: Zane Kraft; Katharine Strouss; William F Sutton; Brad Cleveland; For Yue Tso; Patricia Polacino; Julie Overbaugh; Shiu-Lok Hu; Leonidas Stamatatos
Characterization of neutralizing antibody responses elicited by clade A envelope immunogens derived from early transmitted viruses.
Journal of virology 2008;82(12):5912-21.
2008: Greg Brennan; Yury Kozyrev; Shiu-Lok Hu
TRIMCyp expression in Old World primates Macaca nemestrina and Macaca fascicularis.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(9):3569-74.
2008: Yun Li; Bradley Cleveland; Igor Klots; Bruce Travis; Barbra A Richardson; David Anderson; David Montefiori; Patricia Polacino; Shiu-Lok Hu
Removal of a single N-linked glycan in human immunodeficiency virus type 1 gp120 results in an enhanced ability to induce neutralizing antibody responses.
Journal of virology 2008;82(2):638-51.
2007: Shiu-Lok Hu; Leonidas Stamatatos
Prospects of HIV Env modification as an approach to HIV vaccine design.
Current HIV research 2007;5(6):507-13.
2007: Zandrea Ambrose; Sarah Palmer; Valerie F Boltz; Mary Kearney; Kay Larsen; Patricia Polacino; Leon Flanary; Kelli Oswald; Michael Piatak; Jeremy Smedley; Wei Shao; Norbert Bischofberger; Frank Maldarelli; Jason T Kimata; John W Mellors; Shiu-Lok Hu; John M Coffin; Jeffrey D Lifson; Vineet N KewalRamani
Suppression of viremia and evolution of human immunodeficiency virus type 1 drug resistance in a macaque model for antiretroviral therapy.
Journal of virology 2007;81(22):12145-55.
2007: Greg Brennan; Yury Kozyrev; Toshiaki Kodama; Shiu-Lok Hu
Novel TRIM5 isoforms expressed by Macaca nemestrina.
Journal of virology 2007;81(22):12210-7.
2007: Robert A Rasmussen; Helena Ong; Ruijiang Song; Agnes Chenine; Mila Ayash-Rashkovsky; Shiu-Lok Hu; Patricia Polacino; James ELSE; Francis J Novembre; Ruth Ruprecht
Efficacy of a multigenic protein vaccine containing multimeric HIV gp160 against heterologous SHIV clade C challenges.
AIDS (London, England) 2007;21(14):1841-8.
2007: Patricia Polacino; Brad Cleveland; Yongde Zhu; Jason T Kimata; Julie Overbaugh; David Anderson; Shiu-Lok Hu
Immunogenicity and protective efficacy of Gag/Pol/Env vaccines derived from temporal isolates of SIVmne against cognate virus challenge.
Journal of medical primatology 2007;36(4-5):254-65.
2007: Andreas Gruber; Alistair S Chalmers; Robert A Rasmussen; Helena Ong; Sergei Popov; Janet Andersen; Shiu-Lok Hu; Ruth Ruprecht
Dendritic cell-based vaccine strategy against human immunodeficiency virus clade C: skewing the immune response toward a helper T cell type 2 profile.
Viral immunology 2007;20(1):160-9.
2007: Pushpa Jayaraman; Tuofu Zhu; Lynda Misher; Deepika Mohan; Larene Kuller; Patricia Polacino; Barbra A Richardson; Helle Bielefeldt-Ohmann; David Anderson; Shiu-Lok Hu; Nancy Haigwood
Evidence for persistent, occult infection in neonatal macaques following perinatal transmission of simian-human immunodeficiency virus SF162P3.
Journal of virology 2007;81(2):822-34.
2006: Loren Kinman; Tot Bui; Kay Larsen; Che-Chung Tsai; David Anderson; William R Morton; Shiu-Lok Hu; Rodney J Y Ho
Optimization of lipid-indinavir complexes for localization in lymphoid tissues of HIV-infected macaques.
Journal of acquired immune deficiency syndromes (1999) 2006;42(2):155-61.
2006: Robert A Rasmussen; Helena Ong; Christian Kittel; Claudia R Ruprecht; Flavia Ferrantelli; Shiu-Lok Hu; Patricia Polacino; Patricia Policano; Jennifer McKenna; Jane Moon; Bruce Travis; Ruth Ruprecht
DNA prime/protein boost immunization against HIV clade C: safety and immunogenicity in mice.
Vaccine 2006;24(13):2324-32.
2005: Shiu-Lok Hu
Non-human primate models for AIDS vaccine research.
Current drug targets. Infectious disorders 2005;5(2):193-201.
2005: Caroline S Fernandez; Ivan Stratov; Robert De Rose; Katrina Walsh; C Jane Dale; Miranda Smith; Michael B Agy; Shiu-Lok Hu; Kendall C Krebs; David Ian Watkins; David O'Connor; Miles P Davenport; Stephen J Kent
Rapid viral escape at an immunodominant simian-human immunodeficiency virus cytotoxic T-lymphocyte epitope exacts a dramatic fitness cost.
Journal of virology 2005;79(9):5721-31.
2004: Pushpa Jayaraman; Deepika Mohan; Patricia Polacino; Larene Kuller; Nadeem A Sheikh; Helle Bielefeldt-Ohmann; Barbra Richardson; David Anderson; Shiu-Lok Hu; Nancy Haigwood
Perinatal transmission of SHIV-SF162P3 in Macaca nemestrina.
Journal of medical primatology 2004;33(5-6):243-50.
2004: Loren Kinman; Julie M Worlein; Jennifer Leigh; Helle Bielefeldt-Ohmann; David M Anderson; Shiu-Lok Hu; William R Morton; Bradley D Anderson; Rodney J Y Ho
HIV in central nervous system and behavioral development: an HIV-2287 macaque model of AIDS.
AIDS (London, England) 2004;18(10):1363-70.
2004: Christopher P Locher; Stephanie A Witt; Brittany M Ashlock; Patricia Polacino; Shiu-Lok Hu; Stephen Shiboski; Ann M Schmidt; Michael B Agy; David M Anderson; Silvija I Staprans; Jan zur Megede; Jay A Levy
Human immunodeficiency virus type 2 DNA vaccine provides partial protection from acute baboon infection.
Vaccine 2004;22(17-18):2261-72.
2004: Tuofu Zhu; Shiu-Lok Hu; Feng Feng; Patricia Polacino; Huanliang Liu; Yon Hwangbo; Gerald Learn; James I Mullins; Lawrence Corey
Persistence of low levels of simian immunodeficiency virus in macaques that were transiently viremic by conventional testing.
Virology 2004;323(2):208-19.
2004: Nancy Haigwood; David C Montefiori; William F Sutton; Janela McClure; Andrew J Watson; Gerald Voss; Vanessa M Hirsch; Barbra A Richardson; Norman L Letvin; Shiu-Lok Hu; Philip R Johnson
Passive immunotherapy in simian immunodeficiency virus-infected macaques accelerates the development of neutralizing antibodies.
Journal of virology 2004;78(11):5983-95.
2004: Sally P Mossman; Christopher C Pierce; Andrew J Watson; Michael N Robertson; David C Montefiori; Larene Kuller; Barbra A Richardson; Jeffrey D Bradshaw; Robert J Munn; Shiu-Lok Hu; Philip D Greenberg; Raoul E Benveniste; Nancy Haigwood
Protective immunity to SIV challenge elicited by vaccination of macaques with multigenic DNA vaccines producing virus-like particles.
AIDS research and human retroviruses 2004;20(4):425-34.
2003: Loren Kinman; Scott J Brodie; Che Chung Tsai; Tot Bui; Kay Larsen; Ann Schmidt; David Anderson; William R Morton; Shiu-Lok Hu; Rodney J Y Ho
Lipid-drug association enhanced HIV-1 protease inhibitor indinavir localization in lymphoid tissues and viral load reduction: a proof of concept study in HIV-2287-infected macaques.
Journal of acquired immune deficiency syndromes (1999) 2003;34(4):387-97.
2003: Nicole A Doria-Rose; Claes Ohlen; Patricia Polacino; Christopher C Pierce; Michael T Hensel; Lewis H Kuller; Thera M Mulvania; David Anderson; Philip D Greenberg; Shiu-Lok Hu; Nancy Haigwood
Multigene DNA priming-boosting vaccines protect macaques from acute CD4+-T-cell depletion after simian-human immunodeficiency virus SHIV89.6P mucosal challenge.
Journal of virology 2003;77(21):11563-77.
2003: Nicole A Doria-Rose; Christopher C Pierce; Michael T Hensel; William F Sutton; Nadeem A Sheikh; Patricia Polacino; Larene Kuller; Yong-De Zhu; Shiu-Lok Hu; David Anderson; Nancy Haigwood
Multigene DNA prime-boost vaccines for SHIV89.6P.
Journal of medical primatology 2003;32(4-5):218-28.
2003: Zandrea Ambrose; Jannelle Thompson; Kay Larsen; Larene Kuller; Dennis Panicali; John Clements; Michael B Agy; David C Montefiori; Shiu-Lok Hu; Marnix Bosch
Evidence for immune-mediated reduction of viral replication in Macaca nemestrina mucosally immunized with inactivated SHIV(89.6).
Virology 2003;308(1):178-90.
2002: James M Binley; Rogier W Sanders; Aditi Master; Charmagne S Cayanan; Cheryl Wiley; Linnea Schiffner; Bruce Travis; Shawn E Kuhmann; Dennis R Burton; Shiu-Lok Hu; William C Olson; John P Moore
Enhancing the proteolytic maturation of human immunodeficiency virus type 1 envelope glycoproteins.
Journal of virology 2002;76(6):2606-16.
2002: Robert A Rasmussen; R Hofmann-Lehman; David C Montefiori; Pei-Lin Li; Vladimir Liska; Josef Vlasak; Timothy W Baba; Joern schmitz; Marcelo J Kuroda; H L Robinson; Harold M McClure; S Lu; Shiu-Lok Hu; TA Rizvi; Ruth Ruprecht
DNA prime/protein boost vaccine strategy in neonatal macaques against simian human immunodeficiency virus.
Journal of medical primatology 2002;31(1):40-60.
2002: Arnd M Herz; Michael N Robertson; JB Lynch; Ann Schmidt; M Rabin; C Sherbert; Michael B Agy; David Anderson; Shiu-Lok Hu; Philip D Greenberg; William R Morton
Viral dynamics of early HIV infection in neonatal macaques after oral exposure to HIV-2287: an animal model with implications for maternal-neonatal HIV transmission.
Journal of medical primatology 2002;31(1):29-39.
2001: MA Rey-Cuille; Shiu-Lok Hu
Conserved CXCR4 usage and enhanced replicative capacity of HIV-2/287, an isolate highly pathogenic in Macaca nemestrina.
AIDS (London, England) 2001;15(18):2349-57.
2001: Y Li; MA Rey-Cuille; Shiu-Lok Hu
N-linked glycosylation in the V3 region of HIV type 1 surface antigen modulates coreceptor usage in viral infection.
AIDS research and human retroviruses 2001;17(16):1473-9.
2001: Zandrea Ambrose; Kay Larsen; Jannelle Thompson; Y Stevens; Eric E Finn; Shiu-Lok Hu; Marnix Bosch
Evidence for early local viral replication and local production of antiviral immunity upon mucosal simian-human immunodeficiency virus SHIV(89.6) infection in Macaca nemestrina.
Journal of virology 2001;75(18):8589-96.
2001: Rodney J Y Ho; Kay Larsen; Loren Kinman; C Sherbert; XY Wang; Eric E Finn; C Nosbisch; Ann Schmidt; David Anderson; Shiu-Lok Hu; Michael B Agy; Hans D Ochs; William R Morton; Jashvant D Unadkat
Characterization of a maternal-fetal HIV transmission model using pregnant macaques infected with HIV-2(287).
Journal of medical primatology 2001;30(3):131-40.
2000: Janela McClure; A M Schmidt; MA Rey-Cuille; J Bannink; Lynda Misher; C C Tsai; D M Anderson; William R Morton; Shiu-Lok Hu
Derivation and characterization of a highly pathogenic isolate of human immunodeficiency virus type 2 that causes rapid CD4+ cell depletion in Macaca nemestrina.
Journal of medical primatology 2000;29(3-4):114-26.
2000: Frank Eitner; Yan Cui; G Grouard-Vogel; Kelly Hudkins; Ann Schmidt; Ted A Birkebak; Michael B Agy; Shiu-Lok Hu; William R Morton; David M Anderson; Edward A Clark; Charles E Alpers
Rapid shift from virally infected cells to germinal center-retained virus after HIV-2 infection of macaques.
The American journal of pathology 2000;156(4):1197-207.
1999: Patricia Polacino; V Stallard; J E Klaniecki; Subramaniam Pennathur; David C Montefiori; A J Langlois; Barbra A Richardson; William R Morton; Raoul E Benveniste; Shiu-Lok Hu
Role of immune responses against the envelope and the core antigens of simian immunodeficiency virus SIVmne in protection against homologous cloned and uncloned virus challenge in Macaques.
Journal of virology 1999;73(10):8201-15.
1999: Sally P Mossman; Christopher C Pierce; Michael N Robertson; Andrew J Watson; David C Montefiori; M Rabin; Lewis H Kuller; J Thompson; JB Lynch; William R Morton; Raoul E Benveniste; R Munn; Shiu-Lok Hu; P Greenberg; Nancy Haigwood
Immunization against SIVmne in macaques using multigenic DNA vaccines.
Journal of medical primatology 1999;28(4-5):206-13.
1999: Frank Eitner; Yan Cui; Kelly Hudkins; Ann Schmidt; Ted A Birkebak; Michael B Agy; Shiu-Lok Hu; William R Morton; David M Anderson; Charles E Alpers
Thrombotic microangiopathy in the HIV-2-infected macaque.
The American journal of pathology 1999;155(2):649-61.
1999: Harriet L Robinson; David C Montefiori; R Paul Johnson; Kelledy Manson; M L Kalish; Jeffrey D Lifson; T A Rizvi; S Lu; Shiu-Lok Hu; Gail P Mazzara; Dennis Panicali; James G. Herndon; R Glickman; Maria Angelito Candido; Shari L Lydy; Michael S Wyand; Harold M McClure
Neutralizing antibody-independent containment of immunodeficiency virus challenges by DNA priming and recombinant pox virus booster immunizations.
Nature medicine 1999;5(5):526-34.
1999: Patricia Polacino; V Stallard; David C Montefiori; C R Brown; Barbra A Richardson; William R Morton; Raoul E Benveniste; Shiu-Lok Hu
Protection of macaques against intrarectal infection by a combination immunization regimen with recombinant simian immunodeficiency virus SIVmne gp160 vaccines.
Journal of virology 1999;73(4):3134-46.
1999: Nancy Haigwood; Christopher C Pierce; Michael N Robertson; Andrew J Watson; David C Montefiori; M Rabin; JB Lynch; Lewis H Kuller; J Thompson; William R Morton; Raoul E Benveniste; Shiu-Lok Hu; P Greenberg; Sally P Mossman
Protection from pathogenic SIV challenge using multigenic DNA vaccines.
Immunology letters 1999;66(1-3):183-8.
1999: Patricia Polacino; V Stallard; J E Klaniecki; David C Montefiori; A J Langlois; Barbra A Richardson; Julie Overbaugh; William R Morton; Raoul E Benveniste; Shiu-Lok Hu
Limited breadth of the protective immunity elicited by simian immunodeficiency virus SIVmne gp160 vaccines in a combination immunization regimen.
Journal of virology 1999;73(1):618-30.
1998: Antonia Radaelli; Gunter Kraus; A Schmidt; P Badel; Janela McClure; Shiu-Lok Hu; William R Morton; Carlo De Giuli Morghen; Flossie Wong-Staal; David J Looney
Genetic variation in a human immunodeficiency virus type 2 live-virus Macaca nemestrina vaccine model.
Journal of virology 1998;72(10):7871-84.
1998: Gisela Heidecker; H Muñoz; Patricia A Lloyd; David R Hodge; G K Pei; S W Rick; K Brehm; F W Ruscetti; Lewis H Kuller; Patricia Polacino; Shiu-Lok Hu; William R Morton; Raoul E Benveniste
Sequence diversity of SIV(Mne) Nef in vivo and in vitro.
Journal of medical primatology 1998;27(2-3):73-80.
1998: David J Looney; Janela McClure; S J Kent; Antonia Radaelli; Gunter Kraus; A Schmidt; K Steffy; P Greenberg; Shiu-Lok Hu; William R Morton; Flossie Wong-Staal
A minimally replicative HIV-2 live-virus vaccine protects M. nemestrina from disease after HIV-2(287) challenge.
Virology 1998;242(1):150-60.
1997: A Watson; Janela McClure; J Ranchalis; M Scheibel; A Schmidt; B Kennedy; William R Morton; Nancy Haigwood; Shiu-Lok Hu
Early postinfection antiviral treatment reduces viral load and prevents CD4+ cell decline in HIV type 2-infected macaques.
AIDS research and human retroviruses 1997;13(16):1375-81.
1997: A Watson; J Ranchalis; Bruce Travis; Janela McClure; William F Sutton; P R Johnson; Shiu-Lok Hu; Nancy Haigwood
Plasma viremia in macaques infected with simian immunodeficiency virus: plasma viral load early in infection predicts survival.
Journal of virology 1997;71(1):284-90.
1996: S J Kent; Shiu-Lok Hu; Lawrence Corey; William R Morton; Philip D Greenberg
Detection of simian immunodeficiency virus (SIV)-specific CD8+ T cells in macaques protected from SIV challenge by prior SIV subunit vaccination.
Journal of virology 1996;70(8):4941-7.
1996: Anders Bolmstedt; S Sjölander; John-Erik Stig Hansen; Lennart Akerblom; A Hemming; Shiu-Lok Hu; Bror Morein; Sven-Olof Olofsson
Influence of N-linked glycans in V4-V5 region of human immunodeficiency virus type 1 glycoprotein gp160 on induction of a virus-neutralizing humoral response.
Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association 1996;12(3):213-20.
1996: Rodney J Y Ho; Michael B Agy; William R Morton; M Scheibel; Janela McClure; A Watson; Shiu-Lok Hu; C Nosbisch; N Dorofeeva; Jashvant D Unadkat
Development of a chronically catheterized maternal-fetal macaque model to study in utero mother-to-fetus HIV transmission: a preliminary report.
Journal of medical primatology 1996;25(3):218-24.
1996: Shiu-Lok Hu; Patricia Polacino; V Stallard; J Klaniecki; Sridhar Pennathur; B M Travis; L Misher; H Kornas; A J Langlois; William R Morton; Raoul E Benveniste
Recombinant subunit vaccines as an approach to study correlates of protection against primate lentivirus infection.
Immunology letters 1996;51(1-2):115-9.
1996: Nancy Haigwood; A Watson; W F Sutton; Janela McClure; A Lewis; J Ranchalis; B Travis; G Voss; N L Letvin; Shiu-Lok Hu; V M Hirsch; P R Johnson
Passive immune globulin therapy in the SIV/macaque model: early intervention can alter disease profile.
Immunology letters 1996;51(1-2):107-14.
1996: Shiu-Lok Hu
Recombinant subunit vaccines against primate lentiviruses.
AIDS research and human retroviruses 1996;12(5):451-3.
1994: Tot Bui; T Dykers; Shiu-Lok Hu; C R Faltynek; Rodney J Y Ho
Effect of MTP-PE liposomes and interleukin-7 on induction of antibody and cell-mediated immune responses to a recombinant HIV-envelope protein.
Journal of acquired immune deficiency syndromes 1994;7(8):799-806.
1994: S J Kent; V Stallard; Lawrence Corey; Shiu-Lok Hu; William R Morton; Linda Gritz; D L Panicali; Philip D Greenberg
Analysis of cytotoxic T lymphocyte responses to SIV proteins in SIV-infected macaques using antigen-specific stimulation with recombinant vaccinia and fowl poxviruses.
AIDS research and human retroviruses 1994;10(5):551-60.
1994: A Hemming; Anders Bolmstedt; B Jansson; John-Erik Stig Hansen; B Travis; Shiu-Lok Hu; Sven-Olof Olofsson
Identification of three N-linked glycans in the V4-V5 region of HIV-1 gp 120, dispensable for CD4-binding and fusion activity of gp 120.
Archives of virology 1994;134(3-4):335-44.
1993: E L Cooney; M Juliana McElrath; Lawrence Corey; Shiu-Lok Hu; Ann C Collier; Douglas E (Doug) Arditti; M Hoffman; Robert W Coombs; G E Smith; Philip D Greenberg
Enhanced immunity to human immunodeficiency virus (HIV) envelope elicited by a combined vaccine regimen consisting of priming with a vaccinia recombinant expressing HIV envelope and boosting with gp160 protein.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(5):1882-6.
1993: Shiu-Lok Hu; V Stallard; K Abrams; Glen N Barber; L Kuller; A J Langlois; William R Morton; Raoul E Benveniste
Protection of vaccinia-primed macaques against SIVmne infection by combination immunization with recombinant vaccinia virus and SIVmne gp160.
Journal of medical primatology 1993;22(2-3):92-9.
1992: Anders Bolmstedt; Sven-Olof Olofsson; Eva Sjögren-Jansson; Stig Jeansson; I Sjöblom; Lennart Akerblom; John-Erik Stig Hansen; Shiu-Lok Hu
Carbohydrate determinant NeuAc-Gal beta (1-4) of N-linked glycans modulates the antigenic activity of human immunodeficiency virus type 1 glycoprotein gp120.
The Journal of general virology 1992;73 ( Pt 12)():3099-105.
1992: Shiu-Lok Hu; B M Travis; V Stallard; K Abrams; L Misher; P Moran; J M Zarling; A J Langlois; L Kuller; William R Morton
Immune responses to SIVmne envelope glycoproteins protect macaques from homologous SIV infection.
AIDS research and human retroviruses 1992;8(8):1489-94.
1992: Omar Haffar; P A Moran; M D Smithgall; M L Diegel; P Sridhar; Jeffrey A Ledbetter; J M Zarling; Shiu-Lok Hu
Inhibition of virus production in peripheral blood mononuclear cells from human immunodeficiency virus (HIV) type 1-seropositive donors by treatment with recombinant HIV-like particles.
Journal of virology 1992;66(7):4279-87.
1992: L Chen; M T Mizuno; M C Singhal; Shiu-Lok Hu; Denise A Galloway; Ingegerd Hellström; Karl Erik Hellström
Induction of cytotoxic T lymphocytes specific for a syngeneic tumor expressing the E6 oncoprotein of human papillomavirus type 16.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(8):2617-21.
1992: Shiu-Lok Hu; K Abrams; L Misher; V Stallard; P Moran; J M Zarling; A J Langlois; L Kuller; William R Morton; Raoul E Benveniste
Evaluation of protective efficacy of recombinant subunit vaccines against simian immunodeficiency virus infection of macaques.
Journal of medical primatology 1992;21(2-3):119-25.
1992: Shiu-Lok Hu; K Abrams; Glen N Barber; P Moran; J M Zarling; A J Langlois; L Kuller; William R Morton; Raoul E Benveniste
Protection of macaques against SIV infection by subunit vaccines of SIV envelope glycoprotein gp160.
Science (New York, N.Y.) 1992;255(5043):456-9.
1992: B M Travis; T I Dykers; D Hewgill; Jeffrey A Ledbetter; T T Tsu; Shiu-Lok Hu; J B Lewis
Functional roles of the V3 hypervariable region of HIV-1 gp160 in the processing of gp160 and in the formation of syncytia in CD4+ cells.
Virology 1992;186(1):313-7.
1992: Steven B Kanner; Terrance J Kavanagh; A Grossmann; Shiu-Lok Hu; J B Bolen; Peter S Rabinovitch; Jeffrey A Ledbetter
Sulfhydryl oxidation down-regulates T-cell signaling and inhibits tyrosine phosphorylation of phospholipase C gamma 1.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(1):300-4.
1991: Omar Haffar; M D Smithgall; P A Moran; B M Travis; J M Zarling; Shiu-Lok Hu
HIV-specific humoral and cellular immunity in rabbits vaccinated with recombinant human immunodeficiency virus-like gag-env particles.
Virology 1991;183(2):487-95.
1991: Shiu-Lok Hu; J Klaniecki; T Dykers; P Sridhar; B M Travis
Neutralizing antibodies against HIV-1 BRU and SF2 isolates generated in mice immunized with recombinant vaccinia virus expressing HIV-1 (BRU) envelope glycoproteins and boosted with homologous gp160.
AIDS research and human retroviruses 1991;7(7):615-20.
1991: Anders Bolmstedt; A Hemming; P Flodby; P Berntsson; B Travis; J P Lin; J Ledbetter; T Tsu; Hans Wigzell; Shiu-Lok Hu
Effects of mutations in glycosylation sites and disulphide bonds on processing, CD4-binding and fusion activity of human immunodeficiency virus envelope glycoproteins.
The Journal of general virology 1991;72 ( Pt 6)():1269-77.
1991: E L Cooney; Ann C Collier; Philip D Greenberg; Robert W Coombs; J Zarling; Douglas E (Doug) Arditti; M C Hoffman; Shiu-Lok Hu; Lawrence Corey
Safety of and immunological response to a recombinant vaccinia virus vaccine expressing HIV envelope glycoprotein.
Lancet 1991;337(8741):567-72.
1991: Lieping Chen; E K Thomas; Shiu-Lok Hu; Ingegerd Hellström; Karl Erik Hellström
Human papillomavirus type 16 nucleoprotein E7 is a tumor rejection antigen.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(1):110-4.
1990: Shiu-Lok Hu; B M Travis; J Garrigues; J M Zarling; P Sridhar; T Dykers; J W Eichberg; C Alpers
Processing, assembly, and immunogenicity of human immunodeficiency virus core antigens expressed by recombinant vaccinia virus.
Virology 1990;179(1):321-9.
1990: O Haffar; J Garrigues; B Travis; P Moran; J Zarling; Shiu-Lok Hu
Human immunodeficiency virus-like, nonreplicating, gag-env particles assemble in a recombinant vaccinia virus expression system.
Journal of virology 1990;64(6):2653-9.
1990: Lewis H Kuller; William R Morton; Raoul E Benveniste; Che-Chung Tsai; Edward A Clark; Michael J Gale; Shiu-Lok Hu; Margaret E Thouless; Michael G Katze
Inoculation of Macaca fascicularis with simian immunodeficiency virus, SIVmne immunologic, serologic, and pathologic changes.
Journal of medical primatology 1990;19(3-4):367-80.
1989: Shiu-Lok Hu; J M Zarling; J Chinn; B M Travis; P A Moran; J Sias; L Kuller; William R Morton; Gisela Heidecker; Raoul E Benveniste
Protection of macaques against simian AIDS by immunization with a recombinant vaccinia virus expressing the envelope glycoproteins of simian type D retrovirus.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(18):7213-7.
1987: Shiu-Lok Hu; P N Fultz; Harold M McClure; J W Eichberg; E K Thomas; J Zarling; M C Singhal; S G Kosowski; R B Swenson; Daniel Anderson
Effect of immunization with a vaccinia-HIV env recombinant on HIV infection of chimpanzees.
Nature 1987;328(6132):721-3.
1987: J M Zarling; J W Eichberg; P A Moran; Janela McClure; P Sridhar; Shiu-Lok Hu
Proliferative and cytotoxic T cells to AIDS virus glycoproteins in chimpanzees immunized with a recombinant vaccinia virus expressing AIDS virus envelope glycoproteins.
Journal of immunology (Baltimore, Md. : 1950) 1987;139(4):988-90.
1987: L Madisen; B Travis; Shiu-Lok Hu; A F Purchio
Expression of the human immunodeficiency virus gag gene in insect cells.
Virology 1987;158(1):248-50.
1987: A F Purchio; D R Twardzik; A G Bruce; L Wizental; L Madisen; J E Ranchalis; Shiu-Lok Hu; G Todaro
Synthesis of an active hybrid growth factor (GF) in bacteria: transforming GF-alpha/vaccinia GF fusion protein.
Gene 1987;60(2-3):175-82.
1986: J M Zarling; William R Morton; P A Moran; J McClure; S G Kosowski; Shiu-Lok Hu
T-cell responses to human AIDS virus in macaques immunized with recombinant vaccinia viruses.
Nature 1986;323(6086):344-6.
1986: Shiu-Lok Hu; S G Kosowski; J M Dalrymple
Expression of AIDS virus envelope gene in recombinant vaccinia viruses.
Nature 1986;320(6062):537-40.