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Xianxin Hua

Research Profile

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Multiple Endocrine Neoplasia Type 1

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Buddha Gurung; Tom Curran; Chen-Min Fan; Zijie Feng; Daniel V Iwamoto; Guanghui Jin; Jessica M Y Ng; Austin Thiel; Xianxin Hua
Menin epigenetically represses Hedgehog signaling in MEN1 tumor syndrome.
Austin T Thiel; Jing Huang; Ming Lei; Xianxin Hua
Menin as a hub controlling mixed lineage leukemia.
Jing Huang; Buddha Gurung; Xianxin Hua; Smita Matkar; Juanita L Merchant; Natalia A Veniaminova; Bingbing Wan; Ke Wan; Ming Lei
The same pocket in menin binds both MLL and JUND but has opposite effects on transcription.

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All Publications

2013: Buddha Gurung; Tom Curran; Chen-Min Fan; Zijie Feng; Daniel V Iwamoto; Guanghui Jin; Jessica M Y Ng; Austin Thiel; Xianxin Hua
Menin epigenetically represses Hedgehog signaling in MEN1 tumor syndrome.
Cancer research 2013;73(8):2650-8.
2012: Austin T Thiel; Jing Huang; Ming Lei; Xianxin Hua
Menin as a hub controlling mixed lineage leukemia.
BioEssays : news and reviews in molecular, cellular and developmental biology 2012;34(9):771-80.
2012: Jing Huang; Buddha Gurung; Xianxin Hua; Smita Matkar; Juanita L Merchant; Natalia A Veniaminova; Bingbing Wan; Ke Wan; Ming Lei
The same pocket in menin binds both MLL and JUND but has opposite effects on transcription.
Nature 2012;482(7386):542-6.
2011: Shu-Bin Gao; Xianxin Hua; Yan Chen; Zi-Jie Feng; Bin Xu; Ping Yin; Hong-Hua Zheng; Guang-Hui Jin
Menin represses malignant phenotypes of melanoma through regulating multiple pathways.
Journal of cellular and molecular medicine 2011;15(11):2353-63.
2011: Bin Xu; De-quan Zeng; Yuan Wu; Rong Zheng; Le Gu; Xiao Lin; Xianxin Hua; Guang-Hui Jin
Tumor suppressor menin represses paired box gene 2 expression via Wilms tumor suppressor protein-polycomb group complex.
The Journal of biological chemistry 2011;286(16):13937-44.
2010: Yuqing Yang; Buddha Gurung; Ting Wu; Haoren Wang; Doris A Stoffers; Xianxin Hua
Reversal of preexisting hyperglycemia in diabetic mice by acute deletion of the Men1 gene.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(47):20358-63.
2010: Priya Aggarwal; Laura Pontano Vaites; Jong Kyong Kim; Hestia Mellert; Buddha Gurung; Hiroshi Nakagawa; Meenhard Herlyn; Xianxin Hua; Anil K Rustgi; Steven B McMahon; J Alan Diehl
Nuclear cyclin D1/CDK4 kinase regulates CUL4 expression and triggers neoplastic growth via activation of the PRMT5 methyltransferase.
Cancer cell 2010;18(4):329-40.
2010: Z-J Feng; S-B Gao; Y Wu; X-F Xu; Xianxin Hua; G-H Jin
Lung cancer cell migration is regulated via repressing growth factor PTN/RPTP β/ζ signaling by menin.
Oncogene 2010;29(39):5416-26.
2010: Ting Wu; Xiuli Zhang; Xiaohua Huang; Yuqing Yang; Xianxin Hua
Regulation of cyclin B2 expression and cell cycle G2/m transition by menin.
The Journal of biological chemistry 2010;285(24):18291-300.
2010: Austin T Thiel; Peter Blessington; Tao Zou; Danielle Feather; Xinjiang Wu; Jizhou Yan; Hui Zhang; Zuguo Liu; Patricia Ernst; Gary A Koretzky; Xianxin Hua
MLL-AF9-induced leukemogenesis requires coexpression of the wild-type Mll allele.
Cancer cell 2010;17(2):148-59.
2010: Yuqing Yang; Haoren Wang; Xianxin Hua
Deletion of the Men1 gene prevents streptozotocin-induced hyperglycemia in mice.
Experimental diabetes research 2010;2010():876701.
2009: S-B Gao; Z-J Feng; B Xu; Y Wu; P Yin; Y Yang; Xianxin Hua; G-H Jin
Suppression of lung adenocarcinoma through menin and polycomb gene-mediated repression of growth factor pleiotrophin.
Oncogene 2009;28(46):4095-104.
2009: Ivan P Maillard; Ya-Xiong Chen; Ann Friedman; Yuqing Yang; Anthony T Tubbs; Olga Shestova; Warren S Pear; Xianxin Hua
Menin regulates the function of hematopoietic stem cells and lymphoid progenitors.
Blood 2009;113(8):1661-9.
2009: J Yan; Yuqing Yang; Hongtao Zhang; C King; H-M Kan; Y Cai; Chao-Xing Yuan; George S Bloom; Xianxin Hua
Menin interacts with IQGAP1 to enhance intercellular adhesion of beta-cells.
Oncogene 2009;28(7):973-82.
2008: Xinjiang Wu; Xianxin Hua
Menin, histone h3 methyltransferases, and regulation of cell proliferation: current knowledge and perspective.
Current molecular medicine 2008;8(8):805-15.
2008: S B Gao; Xianxin Hua; G H Jin
Menin regulates endocrine diseases by controlling histone modification and gene transcription.
Annales d'endocrinologie 2008;69(5):426-32.
2008: Manabu Hashimoto; Satoru Kyo; Xianxin Hua; Hidetoshi Tahara; Miki Nakajima; Masahiro Takakura; Junko Sakaguchi; Yoshiko Maida; Mitsuhiro Nakamura; Tomomi Ikoma; Yasunari Mizumoto; Masaki Inoue
Role of menin in the regulation of telomerase activity in normal and cancer cells.
International journal of oncology 2008;33(2):333-40.
2007: Ping La; Yuqing Yang; Satyajit K Karnik; Albert C Silva; Robert W Schnepp; Seung K Kim; Xianxin Hua
Menin-mediated caspase 8 expression in suppressing multiple endocrine neoplasia type 1.
The Journal of biological chemistry 2007;282(43):31332-40.
2007: Xin-jiang Wu; Xianxin Hua
Targeting ROS: selective killing of cancer cells by a cruciferous vegetable derived pro-oxidant compound.
Cancer biology & therapy 2007;6(5):646-7.
2007: Yuqing Yang; Xianxin Hua
In search of tumor suppressing functions of menin.
Molecular and cellular endocrinology 2007;265-266():34-41.
2006: Claudia D Andl; Brenton B Fargnoli; Takaomi Okawa; Mark Bowser; Munenori Takaoka; Hiroshi Nakagawa; Andres Klein-Szanto; Xianxin Hua; Meenhard Herlyn; Anil K Rustgi
Coordinated functions of E-cadherin and transforming growth factor beta receptor II in vitro and in vivo.
Cancer research 2006;66(20):9878-85.
2006: Ping La; A Desmond; Zhaoyuan Hou; Albert C Silva; Robert W Schnepp; Xianxin Hua
Tumor suppressor menin: the essential role of nuclear localization signal domains in coordinating gene expression.
Oncogene 2006;25(25):3537-46.
2006: Robert W Schnepp; Ya-Xiong Chen; Haoren Wang; Tim Cash; Albert Silva; J Alan Diehl; Eric Brown; Xianxin Hua
Mutation of tumor suppressor gene Men1 acutely enhances proliferation of pancreatic islet cells.
Cancer research 2006;66(11):5707-15.
2006: Ya-Xiong Chen; Jizhou Yan; Karen Keeshan; Anthony T Tubbs; Haoren Wang; Albert Silva; Eric J Brown; Jay L Hess; Warren S Pear; Xianxin Hua
The tumor suppressor menin regulates hematopoiesis and myeloid transformation by influencing Hox gene expression.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(4):1018-23.
2006: Jizhou Yan; Ya-Xiong Chen; Angela Desmond; Albert Silva; Yuqing Yang; Haoren Wang; Xianxin Hua
Cdx4 and menin co-regulate Hoxa9 expression in hematopoietic cells.
PloS one 2006;1():e47.
2005: Thomas A Milne; Christina M Hughes; Ricardo Lloyd; Zhaohai Yang; Orit Rozenblatt-Rosen; Yali Dou; Robert W Schnepp; Cynthia Krankel; Virginia A LiVolsi; Denise Gibbs; Xianxin Hua; Robert G Roeder; Matthew Meyerson; Jay L Hess
Menin and MLL cooperatively regulate expression of cyclin-dependent kinase inhibitors.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(3):749-54.
2004: Ping La; Albert C Silva; Zhaoyuan Hou; Haoren Wang; Robert W Schnepp; Nieng Yan; Yigong Shi; Xianxin Hua
Direct binding of DNA by tumor suppressor menin.
The Journal of biological chemistry 2004;279(47):49045-54.
2004: Robert W Schnepp; Zhaoyuan Hou; Haoren Wang; Clark Petersen; Albert Silva; Hisao Masai; Xianxin Hua
Functional interaction between tumor suppressor menin and activator of S-phase kinase.
Cancer research 2004;64(18):6791-6.
2004: Ping La; Robert W Schnepp; Clark D Petersen; Albert C Silva; Xianxin Hua
Tumor suppressor menin regulates expression of insulin-like growth factor binding protein 2.
Endocrinology 2004;145(7):3443-50.
2004: Robert W Schnepp; Hua Mao; Stephen M Sykes; Wei-Xing Zong; Albert Silva; Ping La; Xianxin Hua
Menin induces apoptosis in murine embryonic fibroblasts.
The Journal of biological chemistry 2004;279(11):10685-91.
2003: Shenghao Jin; Hua Mao; Robert W Schnepp; Stephen M Sykes; Albert C Silva; Alan D D'Andrea; Xianxin Hua
Menin associates with FANCD2, a protein involved in repair of DNA damage.
Cancer research 2003;63(14):4204-10.
2003: Robert W Schnepp; Xianxin Hua
A tumor-suppressing duo: TGFbeta and activin modulate a similar transcriptome.
Cancer biology & therapy 2003;2(2):171-2.
2003: Ping La; Trish A Morgan; Stephen M Sykes; Hua Mao; Robert W Schnepp; Clark D Petersen; Xianxin Hua
Fusion proteins of retinoid receptors antagonize TGF-beta-induced growth inhibition of lung epithelial cells.
Oncogene 2003;22(2):198-210.
2001: Xianxin Hua; Craig Thompson
Quiescent T cells: actively maintaining inactivity.
Nature immunology 2001;2(12):1097-8.
2001: Alan C Mullen; Anne S Hutchins; Alejandro V Villarino; Hubert W Lee; Frances A High; Nezih Cereb; Soo Y Yang; Xianxin Hua; Steven L Reiner
Cell cycle controlling the silencing and functioning of mammalian activators.
Current biology : CB 2001;11(21):1695-9.
2001: Yi E Sun; M Nadal-Vicens; S Misono; Michael Z Lin; Ana M Zubiaga; Xianxin Hua; G Fan; Michael E Greenberg
Neurogenin promotes neurogenesis and inhibits glial differentiation by independent mechanisms.
Cell 2001;104(3):365-76.
2000: Y Yamamura; Xianxin Hua; S Bergelson; Harvey Lodish
Critical role of Smads and AP-1 complex in transforming growth factor-beta -dependent apoptosis.
The Journal of biological chemistry 2000;275(46):36295-302.
2000: Xianxin Hua; Z A Miller; Hassina Benchabane; Jeffrey L Wrana; Harvey Lodish
Synergism between transcription factors TFE3 and Smad3 in transforming growth factor-beta-induced transcription of the Smad7 gene.
The Journal of biological chemistry 2000;275(43):33205-8.
2000: Xiaoxia Li; Mairead Commane; H Nie; Xianxin Hua; Moitreyee Chatterjee-Kishore; Dave Wald; M Haag; George R Stark
Act1, an NF-kappa B-activating protein.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(19):10489-93.
1999: Xianxin Hua; Z A Miller; G Wu; Y Shi; Harvey Lodish
Specificity in transforming growth factor beta-induced transcription of the plasminogen activator inhibitor-1 gene: interactions of promoter DNA, transcription factor muE3, and Smad proteins.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(23):13130-5.
1998: Xianxin Hua; X Liu; Dominic Ansari; Harvey Lodish
Synergistic cooperation of TFE3 and smad proteins in TGF-beta-induced transcription of the plasminogen activator inhibitor-1 gene.
Genes & development 1998;12(19):3084-95.
1996: A Nohturfft; Xianxin Hua; Michael S Brown; Joseph L Goldstein
Recurrent G-to-A substitution in a single codon of SREBP cleavage-activating protein causes sterol resistance in three mutant Chinese hamster ovary cell lines.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(24):13709-14.
1996: Xianxin Hua; A Nohturfft; Joseph L Goldstein; Michael S Brown
Sterol resistance in CHO cells traced to point mutation in SREBP cleavage-activating protein.
Cell 1996;87(3):415-26.
1996: J Sakai; Elizabeth A. Duncan; Robert B Rawson; Xianxin Hua; Michael S Brown; Joseph L Goldstein
Sterol-regulated release of SREBP-2 from cell membranes requires two sequential cleavages, one within a transmembrane segment.
Cell 1996;85(7):1037-46.
1996: Xianxin Hua; J Sakai; Michael S Brown; Joseph L Goldstein
Regulated cleavage of sterol regulatory element binding proteins requires sequences on both sides of the endoplasmic reticulum membrane.
The Journal of biological chemistry 1996;271(17):10379-84.
1995: Xianxin Hua; J Sakai; Y K Ho; Joseph L Goldstein; Michael S Brown
Hairpin orientation of sterol regulatory element-binding protein-2 in cell membranes as determined by protease protection.
The Journal of biological chemistry 1995;270(49):29422-7.
1995: Xianxin Hua; J Wu; Joseph L Goldstein; Michael S Brown; Helen H Hobbs
Structure of the human gene encoding sterol regulatory element binding protein-1 (SREBF1) and localization of SREBF1 and SREBF2 to chromosomes 17p11.2 and 22q13.
Genomics 1995;25(3):667-73.
1994: Xinhe Wang; R Sato; Michael S Brown; Xianxin Hua; Joseph L Goldstein
SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis.
Cell 1994;77(1):53-62.
1993: Xianxin Hua; C Yokoyama; J Wu; M R Briggs; Michael S Brown; Joseph L Goldstein; Xinhe Wang
SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(24):11603-7.
1993: C Yokoyama; Xinhe Wang; M R Briggs; A Admon; J Wu; Xianxin Hua; Joseph L Goldstein; Michael S Brown
SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene.
Cell 1993;75(1):187-97.
1993: Xinhe Wang; M R Briggs; Xianxin Hua; C Yokoyama; Joseph L Goldstein; Michael S Brown
Nuclear protein that binds sterol regulatory element of low density lipoprotein receptor promoter. II. Purification and characterization.
The Journal of biological chemistry 1993;268(19):14497-504.