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Richard Auchus

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TOP 3
Richard J Auchus
Introduction to the 2012 Keith L. Parker memorial lecturer: Walter L. Miller, MD.
Hwei-Ming Peng; Richard J Auchus
The action of cytochrome b(5) on CYP2E1 and CYP2C19 activities requires anionic residues D58 and D65.
Richard J Auchus; Walter L Miller
Defects in androgen biosynthesis causing 46,XY disorders of sexual development.

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2013: Richard J Auchus
Introduction to the 2012 Keith L. Parker memorial lecturer: Walter L. Miller, MD.
Molecular and cellular endocrinology 2013;371(1-2):2-4.
2013: Hwei-Ming Peng; Richard J Auchus
The action of cytochrome b(5) on CYP2E1 and CYP2C19 activities requires anionic residues D58 and D65.
Biochemistry 2013;52(1):210-20.
2012: Richard J Auchus; Walter L Miller
Defects in androgen biosynthesis causing 46,XY disorders of sexual development.
Seminars in reproductive medicine 2012;30(5):417-26.
2012: Francis K Yoshimoto; Jennifer A Yoshimoto; Yishan Zhou; Susan Matthew; Hwei-Ming Peng; Kamalesh K Sharma; David Stidd; Richard J Auchus
Minor activities and transition state properties of the human steroid hydroxylases cytochromes P450c17 and P450c21, from reactions observed with deuterium-labeled substrates.
Biochemistry 2012;51(36):7064-77.
2012: Prafull Raheja; Zhongyun Wang; Beverley Adams-Huet; Debbie Arbique; Richard J Auchus; Angela Price; Wanpen Vongpatanasin
Spironolactone prevents chlorthalidone-induced sympathetic activation and insulin resistance in hypertensive patients.
Hypertension 2012;60(2):319-25.
2012: Rui Li; Jiayan Liu; Richard J Auchus; Kai-Hsiung Chang; Kristen Evaul; Kamalesh K Sharma; Jennifer Yoshimoto; Nima Sharifi
Abiraterone inhibits 3β-hydroxysteroid dehydrogenase: a rationale for increasing drug exposure in castration-resistant prostate cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2012;18(13):3571-9.
2012: Nima Sharifi; Richard J Auchus
Steroid biosynthesis and prostate cancer.
Steroids 2012;77(7):719-26.
2012: Yong Mong Bee; Chandran Manju; Mahboubeh Papari-Zareei; Richard J Auchus
Phenotypic variation in a Chinese family with 46,XY and 46,XX 17α-hydroxylase deficiency.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 2012;28(4):322-5.
2012: Gerhardt Attard; Richard J Auchus; Amy Mulick Cassidy; Mitch Dowsett; Elizabeth Folkerd; Beverly A Hughes; Nikhil Babu Oommen; Alison H M Reid; Emilda Thompson; Wiebke Arlt; Johann S de Bono
Clinical and biochemical consequences of CYP17A1 inhibition with abiraterone given with and without exogenous glucocorticoids in castrate men with advanced prostate cancer.
The Journal of clinical endocrinology and metabolism 2012;97(2):507-16.
2012: Francis K Yoshimoto; Melissa C Desilets; Richard J Auchus
Synthesis of halogenated pregnanes, mechanistic probes of steroid hydroxylases CYP17A1 and CYP21A2.
The Journal of steroid biochemistry and molecular biology 2012;128(1-2):38-50.
2011: Kai-Hsiung Chang; Rui Li; Mahboubeh Papari-Zareei; Lori Watumull; Yan Daniel Zhao; Richard J Auchus; Nima Sharifi
Dihydrotestosterone synthesis bypasses testosterone to drive castration-resistant prostate cancer.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(33):13728-33.
2011: Dario Mizrachi; Zhu Wang; Kamalesh K Sharma; Manisha K Gupta; Keliang Xu; Christopher R Dwyer; Richard J Auchus
Why human cytochrome P450c21 is a progesterone 21-hydroxylase.
Biochemistry 2011;50(19):3968-74.
2011: Richard J Auchus; Jean D Wilson
The life and scientific contributions of Keith L. Parker, 1953-2008.
Molecular and cellular endocrinology 2011;336(1-2):191-2.
2011: Richard J Auchus
Primary aldosteronism and a Texas two-step.
Reviews in endocrine & metabolic disorders 2011;12(1):37-42.
2011: Hans K Ghayee; Juilee Rege; Lori Watumull; Fiemu E Nwariaku; Kelley S Carrick; William E Rainey; Walter L Miller; Richard J Auchus
Clinical, biochemical, and molecular characterization of macronodular adrenocortical hyperplasia of the zona reticularis: a new syndrome.
The Journal of clinical endocrinology and metabolism 2011;96(2):E243-50.
2011: Walter L Miller; Richard J Auchus
The molecular biology, biochemistry, and physiology of human steroidogenesis and its disorders.
Endocrine reviews 2011;32(1):81-151.
2011: Richard J Auchus
The physiology and biochemistry of adrenarche.
Endocrine development 2011;20():20-7.
2011: Alice Y Chang; Colby Ayers; Abu Minhajuddin; Tulika Jain; Pamela Nurenberg; James A de Lemos; Robert A Wild; Richard J Auchus
Polycystic ovarian syndrome and subclinical atherosclerosis among women of reproductive age in the Dallas heart study.
Clinical endocrinology 2011;74(1):89-96.
2010: Marcos S Neres; Richard J Auchus; Cedric H L Shackleton; Claudio E Kater
Distinctive profile of the 17-hydroxylase and 17,20-lyase activities revealed by urinary steroid metabolomes of patients with CYP17 deficiency.
Arquivos brasileiros de endocrinologia e metabologia 2010;54(9):826-32.
2010: Nima Sharifi; Michael J McPhaul; Richard J Auchus
"Getting from here to there"--mechanisms and limitations to the activation of the androgen receptor in castration-resistant prostate cancer.
Journal of investigative medicine : the official publication of the American Federation for Clinical Research 2010;58(8):938-44.
2010: Fabíola Costenaro; Ticiana C Rodrigues; Claudio E Kater; Richard J Auchus; Mahboubeh Papari-Zareei; Mauro A Czepielewski
Combined 17α-hydroxylase/17,20-lyase deficiency due to p.R96W mutation in the CYP17 gene in a Brazilian patient.
Arquivos brasileiros de endocrinologia e metabologia 2010;54(8):744-8.
2010: Andrew C Kontak; Zhongyun Wang; Debbie Arbique; Beverley Adams-Huet; Richard J Auchus; Shawna D Nesbitt; Ronald G Victor; Wanpen Vongpatanasin
Reversible sympathetic overactivity in hypertensive patients with primary aldosteronism.
The Journal of clinical endocrinology and metabolism 2010;95(10):4756-61.
2010: Kristen Evaul; Rui Li; Mahboubeh Papari-Zareei; Richard J Auchus; Nima Sharifi
3beta-hydroxysteroid dehydrogenase is a possible pharmacological target in the treatment of castration-resistant prostate cancer.
Endocrinology 2010;151(8):3514-20.
2010: Richard J Auchus
Congenital adrenal hyperplasia in adults.
Current opinion in endocrinology, diabetes, and obesity 2010;17(3):210-6.
2010: Richard J Auchus; Alice Y Chang
46,XX DSD: the masculinised female.
Best practice & research. Clinical endocrinology & metabolism 2010;24(2):219-42.
2010: Richard J Auchus
Management of the adult with congenital adrenal hyperplasia.
International journal of pediatric endocrinology 2010;2010():614107.
2009: Daniel P Sherbet; Oleg Guryev; Mahboubeh Papari-Zareei; Dario Mizrachi; Siayareh Rambally; Sharareh Akbar; Richard J Auchus
Biochemical factors governing the steady-state estrone/estradiol ratios catalyzed by human 17beta-hydroxysteroid dehydrogenases types 1 and 2 in HEK-293 cells.
Endocrinology 2009;150(9):4154-62.
2009: Alice Y Chang; Richard J Auchus
Venus and the heart: endocrine influences on cardiovascular health in women.
Seminars in reproductive medicine 2009;27(4):297-8.
2009: Zhu Wang; X Edward Zhou; Daniel L Motola; Xin Gao; Kelly Suino-Powell; Aoife Conneely; Craig Ogata; Kamalesh K Sharma; Richard J Auchus; James B Lok; John M Hawdon; Steven A Kliewer; H Eric Xu; David J Mangelsdorf
Identification of the nuclear receptor DAF-12 as a therapeutic target in parasitic nematodes.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(23):9138-43.
2009: Kamalesh K Sharma; Zhu Wang; Daniel L Motola; Carolyn L Cummins; David J Mangelsdorf; Richard J Auchus
Synthesis and activity of dafachronic acid ligands for the C. elegans DAF-12 nuclear hormone receptor.
Molecular endocrinology (Baltimore, Md.) 2009;23(5):640-8.
2009: Dileep V Menon; Debbie Arbique; Zhongyun Wang; Beverley Adams-Huet; Richard J Auchus; Wanpen Vongpatanasin
Differential effects of chlorthalidone versus spironolactone on muscle sympathetic nerve activity in hypertensive patients.
The Journal of clinical endocrinology and metabolism 2009;94(4):1361-6.
2009: Dario Mizrachi; Richard J Auchus
Androgens, estrogens, and hydroxysteroid dehydrogenases.
Molecular and cellular endocrinology 2009;301(1-2):37-42.
2009: Hans K Ghayee; Bas Havekes; Eleonora P M Corssmit; Graeme Eisenhofer; Stephen R Hammes; Zahid Ahmad; Alexander Tessnow; Ivica Lazúrová; Karen T Adams; Antonio T Fojo; Karel Pacak; Richard J Auchus
Mediastinal paragangliomas: association with mutations in the succinate dehydrogenase genes and aggressive behavior.
Endocrine-related cancer 2009;16(1):291-9.
2009: Richard J Auchus
Non-traditional metabolic pathways of adrenal steroids.
Reviews in endocrine & metabolic disorders 2009;10(1):27-32.
2009: Richard J Auchus; Christina Michaelis; Frank H Wians; Bart L Dolmatch; Shellie C Josephs; Clayton K Trimmer; Matthew E Anderson; Fiemu E Nwariaku
Rapid cortisol assays improve the success rate of adrenal vein sampling for primary aldosteronism.
Annals of surgery 2009;249(2):318-21.
2009: Serap Turan; Abdullah Bereket; Tulay Guran; Teoman Akcay; Mahboubeh Papari-Zareei; Richard J Auchus
Puberty in a case with novel 17-hydroxylase mutation and the putative role of estrogen in development of pubic hair.
European journal of endocrinology / European Federation of Endocrine Societies 2009;160(2):325-30.
2009: Jean D Wilson; Marilyn Renfree; Richard J Auchus; Andrew J Pask; Geoffrey Shaw
Formation of 5alpha-reduced androgens in the testes and urogenital tract of the grey short-tailed opossum, Monodelphis domestica.
Reproduction, fertility, and development 2009;21(5):649-54.
2008: Alice Y Chang; Hans K Ghayee; Richard J Auchus
Dehydroepiandrosterone replacement therapy--panacea, snake oil, or a bit of both?
Nature clinical practice. Endocrinology & metabolism 2008;4(8):442-3.
2008: Rupa Patel; Gail Peterson; Anand Rohatgi; Hans K Ghayee; Ellen C Keeley; Richard J Auchus; Alice Y Chang
Hyperthyroidism-associated coronary vasospasm with myocardial infarction and subsequent euthyroid angina.
Thyroid : official journal of the American Thyroid Association 2008;18(2):273-6.
2008: Hans K Ghayee; Richard J Auchus
Clinical implications of androgen synthesis via 5alpha-reduced precursors.
Endocrine development 2008;13():55-66.
2007: Ian C Mitchell; Richard J Auchus; Kavita Juneja; Alice Y Chang; Shelby A Holt; William H Snyder; Fiemu E Nwariaku
"Subclinical Cushing's syndrome" is not subclinical: improvement after adrenalectomy in 9 patients.
Surgery 2007;142(6):900-5; discussion 905.e1.
2007: Hans K Ghayee; Richard J Auchus
Basic concepts and recent developments in human steroid hormone biosynthesis.
Reviews in endocrine & metabolic disorders 2007;8(4):289-300.
2007: Richard J Auchus; Fiemu E Nwariaku
Primary aldosteronism.
Current cardiology reports 2007;9(6):447-52.
2007: Richard J Auchus; Mark H Drazner
Will the lessons from primary aldosteronism change the treatment of hypertension and left ventricular hypertrophy?
Hypertension 2007;50(5):837-9.
2007: Richard J Auchus; Donald W Chandler; Sarita Singeetham; Neema Chokshi; Fiemu E Nwariaku; Bart L Dolmatch; Shelby A Holt; Frank H Wians; Shellie C Josephs; Clayton K Trimmer; Jorge Lopera; Wanpen Vongpatanasin; Shawna D Nesbitt; David Leonard; Ronald G Victor
Measurement of 18-hydroxycorticosterone during adrenal vein sampling for primary aldosteronism.
The Journal of clinical endocrinology and metabolism 2007;92(7):2648-51.
2007: Lin Lin; Oya Ercan; Jamal Raza; Christine P Burren; Sarah M Creighton; Richard J Auchus; Mehul T Dattani; John C Achermann
Variable phenotypes associated with aromatase (CYP19) insufficiency in humans.
The Journal of clinical endocrinology and metabolism 2007;92(3):982-90.
2007: Daniel P Sherbet; Mahboubeh Papari-Zareei; Naveed Khan; Kamalesh K Sharma; Andrew Brandmaier; Siayareh Rambally; Arhana Chattopadhyay; A S Andersson; Anil Agarwal; Richard J Auchus
Cofactors, redox state, and directional preferences of hydroxysteroid dehydrogenases.
Molecular and cellular endocrinology 2007;265-266():83-8.
2007: Kathleen Mulligan; Robert Zackin; Jamie H Von Roenn; Margaret A Chesney; Merrill J Egorin; Fred R Sattler; Constance A Benson; Tun Liu; Triin Umbleja; Sharon Shriver; Richard J Auchus; Morris Schambelan
Testosterone supplementation of megestrol therapy does not enhance lean tissue accrual in men with human immunodeficiency virus-associated weight loss: a randomized, double-blind, placebo-controlled, multicenter trial.
The Journal of clinical endocrinology and metabolism 2007;92(2):563-70.
2007: Russell M Canham; Sandeep R Das; David Leonard; Shuaib M Abdullah; Sameer K Mehta; Anne K Chung; Jia-Ling Li; Ronald G Victor; Richard J Auchus; Mark H Drazner
Alpha2cDel322-325 and beta1Arg389 adrenergic polymorphisms are not associated with reduced left ventricular ejection fraction or increased left ventricular volume.
Journal of the American College of Cardiology 2007;49(2):274-6.
2007: Alice Y Chang; Shuaib M Abdullah; Tulika Jain; Harold G Stanek; Sandeep R Das; Darren K McGuire; Richard J Auchus; James A de Lemos
Associations among androgens, estrogens, and natriuretic peptides in young women: observations from the Dallas Heart Study.
Journal of the American College of Cardiology 2007;49(1):109-16.
2006: Berrin Ergun-Longmire; Richard J Auchus; Mahboubeh Papari-Zareei; Susan Tansil; Robert C Wilson; Maria I New
Two novel mutations found in a patient with 17alpha-hydroxylase enzyme deficiency.
The Journal of clinical endocrinology and metabolism 2006;91(10):4179-82.
2006: Jia-Ling Li; Russell M Canham; Wanpen Vongpatanasin; David Leonard; Richard J Auchus; Ronald G Victor
Do allelic variants in alpha2A and alpha2C adrenergic receptors predispose to hypertension in blacks?
Hypertension 2006;47(6):1140-6.
2006: A M Brooke; N F Taylor; J H Shepherd; M E Gore; T Ahmad; L Lin; G Rumsby; Mahboubeh Papari-Zareei; Richard J Auchus; John C Achermann; John P Monson
A novel point mutation in P450c17 (CYP17) causing combined 17alpha-hydroxylase/17,20-lyase deficiency.
The Journal of clinical endocrinology and metabolism 2006;91(6):2428-31.
2006: Fiemu E Nwariaku; Barbra S Miller; Richard J Auchus; Shelby Holt; Lori Watumull; Bart L Dolmatch; Shawna D Nesbitt; Wanpen Vongpatanasin; Ronald G Victor; Frank H Wians; Edward Livingston; William H Snyder
Primary hyperaldosteronism: effect of adrenal vein sampling on surgical outcome.
Archives of surgery (Chicago, Ill. : 1960) 2006;141(5):497-502; discussion 502-3.
2006: geoffrey shaw; Jane Fenelon; Michelle Sichlau; Richard J Auchus; Jean D Wilson; Marilyn Renfree
Role of the alternate pathway of dihydrotestosterone formation in virilization of the Wolffian ducts of the tammar wallaby, Macropus eugenii.
Endocrinology 2006;147(5):2368-73.
2006: Mahboubeh Papari-Zareei; Andrew Brandmaier; Richard J Auchus
Arginine 276 controls the directional preference of AKR1C9 (rat liver 3alpha-hydroxysteroid dehydrogenase) in human embryonic kidney 293 cells.
Endocrinology 2006;147(4):1591-7.
2006: Kamalesh K Sharma; Annika Lindqvist; Xin J Zhou; Richard J Auchus; Trevor M Penning; A S Andersson
Deoxycorticosterone inactivation by AKR1C3 in human mineralocorticoid target tissues.
Molecular and cellular endocrinology 2006;248(1-2):79-86.
2006: Daniel L Motola; Carolyn L Cummins; Veerle Rottiers; Kamalesh K Sharma; Tingting Li; Yong Li; Kelly Suino-Powell; H Eric Xu; Richard J Auchus; Adam Antebi; David J Mangelsdorf
Identification of ligands for DAF-12 that govern dauer formation and reproduction in C. elegans.
Cell 2006;124(6):1209-23.
2006: John M Hollier; Dan F Martin; Darin M Bell; Jia-Ling Li; Mike G Chirachanchai; Dileep V Menon; David Leonard; Xiaodong Wu; Richard S Cooper; Colin McKenzie; Ronald G Victor; Richard J Auchus
Epithelial sodium channel allele T594M is not associated with blood pressure or blood pressure response to amiloride.
Hypertension 2006;47(3):428-33.
2006: Jacqueline L Naffin-Olivos; Richard J Auchus
Human cytochrome b5 requires residues E48 and E49 to stimulate the 17,20-lyase activity of cytochrome P450c17.
Biochemistry 2006;45(3):755-62.
2005: Richard J Auchus
Miscellaneous endocrine causes of hypertension.
Current cardiology reports 2005;7(6):418-24.
2005: Anil Agarwal; Richard J Auchus
Minireview: cellular redox state regulates hydroxysteroid dehydrogenase activity and intracellular hormone potency.
Endocrinology 2005;146(6):2531-8.
2005: Jean D Wilson; geoffrey shaw; Marilyn Renfree; Richard J Auchus; Michael W Leihy; Douglas C Eckery
Ontogeny and pathway of formation of 5alpha-androstane-3alpha,17beta-diol in the testes of the immature brushtail possum Trichosurus vulpecula.
Reproduction, fertility, and development 2005;17(6):603-9.
2004: Richard J Auchus
Overview of dehydroepiandrosterone biosynthesis.
Seminars in reproductive medicine 2004;22(4):281-8.
2004: Richard J Auchus
The backdoor pathway to dihydrotestosterone.
Trends in endocrinology and metabolism: TEM 2004;15(9):432-8.
2004: Naveed Khan; Kamalesh K Sharma; A S Andersson; Richard J Auchus
Human 17beta-hydroxysteroid dehydrogenases types 1, 2, and 3 catalyze bi-directional equilibrium reactions, rather than unidirectional metabolism, in HEK-293 cells.
Archives of biochemistry and biophysics 2004;429(1):50-9.
2004: Mala S Mahendroo; Jean D Wilson; James A Richardson; Richard J Auchus
Steroid 5alpha-reductase 1 promotes 5alpha-androstane-3alpha,17beta-diol synthesis in immature mouse testes by two pathways.
Molecular and cellular endocrinology 2004;222(1-2):113-20.
2004: Richard J Auchus; William E Rainey
Adrenarche - physiology, biochemistry and human disease.
Clinical endocrinology 2004;60(3):288-96.
2004: Marivânia Costa-Santos; Claudio E Kater; Richard J Auchus
Two prevalent CYP17 mutations and genotype-phenotype correlations in 24 Brazilian patients with 17-hydroxylase deficiency.
The Journal of clinical endocrinology and metabolism 2004;89(1):49-60.
2004: Marivania Costa-Santos; Claudio E Kater; Eduardo P Dias; Richard J Auchus
Two intronic mutations cause 17-hydroxylase deficiency by disrupting splice acceptor sites: direct demonstration of aberrant splicing and absent enzyme activity by expression of the entire CYP17 gene in HEK-293 cells.
The Journal of clinical endocrinology and metabolism 2004;89(1):43-8.
2003: Daniel P Sherbet; Dov Tiosano; Kerri M Kwist; Ze'ev Hochberg; Richard J Auchus
CYP17 mutation E305G causes isolated 17,20-lyase deficiency by selectively altering substrate binding.
The Journal of biological chemistry 2003;278(49):48563-9.
2003: Manisha K Gupta; Oleg Guryev; Richard J Auchus
5alpha-reduced C21 steroids are substrates for human cytochrome P450c17.
Archives of biochemistry and biophysics 2003;418(2):151-60.
2003: Anil Agarwal; Jean-Pierre Fryns; Richard J Auchus; Abhimanyu Garg
Zinc metalloproteinase, ZMPSTE24, is mutated in mandibuloacral dysplasia.
Human molecular genetics 2003;12(16):1995-2001.
2003: Christa E Flück; Walter L Miller; Richard J Auchus
The 17, 20-lyase activity of cytochrome p450c17 from human fetal testis favors the delta5 steroidogenic pathway.
The Journal of clinical endocrinology and metabolism 2003;88(8):3762-6.
2003: Richard J Auchus
Aldo is back: recent advances and unresolved controversies in hyperaldosteronism.
Current opinion in nephrology and hypertension 2003;12(2):153-8.
2003: Jean D Wilson; Richard J Auchus; Michael W Leihy; Oleg Guryev; Ronald W Estabrook; Susan M Osborn; geoffrey shaw; Marilyn Renfree
5alpha-androstane-3alpha,17beta-diol is formed in tammar wallaby pouch young testes by a pathway involving 5alpha-pregnane-3alpha,17alpha-diol-20-one as a key intermediate.
Endocrinology 2003;144(2):575-80.
2003: Richard J Auchus; A Sampath Kumar; C Andrew Boswell; Manisha K Gupta; Kristen Bruce; Nigam P Rath; Douglas F Covey
The enantiomer of progesterone (ent-progesterone) is a competitive inhibitor of human cytochromes P450c17 and P450c21.
Archives of biochemistry and biophysics 2003;409(1):134-44.
2002: Wiebke Arlt; John Martens; Maengseok Song; Jonathan T Wang; Richard J Auchus; Walter L Miller
Molecular evolution of adrenarche: structural and functional analysis of p450c17 from four primate species.
Endocrinology 2002;143(12):4665-72.
2002: Richard J Auchus; Manisha K Gupta
Towards a unifying mechanism for CYP17 mutations that cause isolated 17,20-lyase deficiency.
Endocrine research 2002;28(4):443-7.
2001: Lindsey B Lutz; L M Cole; M K Gupta; K W Kwist; Richard J Auchus; Stephen R Hammes
Evidence that androgens are the primary steroids produced by Xenopus laevis ovaries and may signal through the classical androgen receptor to promote oocyte maturation.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(24):13728-33.
2001: Manisha K Gupta; David H Geller; Richard J Auchus
Pitfalls in characterizing P450c17 mutations associated with isolated 17,20-lyase deficiency.
The Journal of clinical endocrinology and metabolism 2001;86(9):4416-23.
2001: Wiebke Arlt; Richard J Auchus; Walter L Miller
Thiazolidinediones but not metformin directly inhibit the steroidogenic enzymes P450c17 and 3beta -hydroxysteroid dehydrogenase.
The Journal of biological chemistry 2001;276(20):16767-71.
2001: Richard J Auchus
The genetics, pathophysiology, and management of human deficiencies of P450c17.
Endocrinology and metabolism clinics of North America 2001;30(1):101-19, vii.
2000: Richard J Auchus; K Worthy; David H Geller; Walter L Miller
Probing structural and functional domains of human P450c17.
Endocrine research 2000;26(4):695-703.
2000: John Martens; David H Geller; Wiebke Arlt; Richard J Auchus; V S Ossovskaya; H Rodriguez; A Dunaif; Walter L Miller
Enzymatic activities of P450c17 stably expressed in fibroblasts from patients with the polycystic ovary syndrome.
The Journal of clinical endocrinology and metabolism 2000;85(11):4338-46.
2000: Richard J Auchus; David H Geller; T C Lee; K M Worthy
The function and roles of P450c17 in androgen excess states.
Journal of pediatric endocrinology & metabolism : JPEM 2000;13 Suppl 5():1271-5.
1999: Melvin M Grumbach; Richard J Auchus
Estrogen: consequences and implications of human mutations in synthesis and action.
The Journal of clinical endocrinology and metabolism 1999;84(12):4677-94.
1999: Richard J Auchus; Walter L Miller
Molecular modeling of human P450c17 (17alpha-hydroxylase/17,20-lyase): insights into reaction mechanisms and effects of mutations.
Molecular endocrinology (Baltimore, Md.) 1999;13(7):1169-82.
1999: T C Lee; Walter L Miller; Richard J Auchus
Medroxyprogesterone acetate and dexamethasone are competitive inhibitors of different human steroidogenic enzymes.
The Journal of clinical endocrinology and metabolism 1999;84(6):2104-10.
1999: David H Geller; Richard J Auchus; Walter L Miller
P450c17 mutations R347H and R358Q selectively disrupt 17,20-lyase activity by disrupting interactions with P450 oxidoreductase and cytochrome b5.
Molecular endocrinology (Baltimore, Md.) 1999;13(1):167-75.
1998: Walter L Miller; David H Geller; Richard J Auchus
The molecular basis of isolated 17,20 lyase deficiency.
Endocrine research 1998;24(3-4):817-25.
1998: Richard J Auchus
The use of computational chemistry in the study of sex steroid biosynthesis.
Endocrine research 1998;24(3-4):541-7.
1998: Richard J Auchus; T C Lee; Walter L Miller
Cytochrome b5 augments the 17,20-lyase activity of human P450c17 without direct electron transfer.
The Journal of biological chemistry 1998;273(6):3158-65.
1998: Richard J Auchus; David H Geller; T C Lee; Walter L Miller
The regulation of human P450c17 activity: relationship to premature adrenarche, insulin resistance and the polycystic ovary syndrome.
Trends in endocrinology and metabolism: TEM 1998;9(2):47-50.
1997: David H Geller; Richard J Auchus; B B Mendonça; Walter L Miller
The genetic and functional basis of isolated 17,20-lyase deficiency.
Nature genetics 1997;17(2):201-5.
1997: Walter L Miller; Richard J Auchus; David H Geller
The regulation of 17,20 lyase activity.
Steroids 1997;62(1):133-42.