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Jian-Dong Huang

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Zai Wang; Wenqian Xue; Ju Cui; Xiuling Li; Raozhou Lin; Jian-Dong Huang
Dissect Kif5b in nuclear positioning during myogenesis: the light chain binding domain and the autoinhibitory peptide are both indispensable.
Zai Wang; Wai Man Wong; Wutian Wu; Wenqian Xue; Xiuling Li; Raozhou Lin; Julian A Tanner; Jing Wang; Peigang Wang; Kathryn S E Cheah; Ju Cui; Jian-Dong Huang
Kif5b controls the localization of myofibril components for their assembly and linkage to the myotendinous junctions.
Qiuju Yuan; Wing Hin Chau; Jian-Dong Huang; Huanxing Su; Cheung Toa Ng; Wutian Wu; Zhi-Xiu Lin
Behavioral stress fails to accelerate the onset and progression of plaque pathology in the brain of a mouse model of Alzheimer's disease.

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2013: Zai Wang; Wenqian Xue; Ju Cui; Xiuling Li; Raozhou Lin; Jian-Dong Huang
Dissect Kif5b in nuclear positioning during myogenesis: the light chain binding domain and the autoinhibitory peptide are both indispensable.
Biochemical and biophysical research communications 2013;432(2):242-7.
2013: Zai Wang; Wai Man Wong; Wutian Wu; Wenqian Xue; Xiuling Li; Raozhou Lin; Julian A Tanner; Jing Wang; Peigang Wang; Kathryn S E Cheah; Ju Cui; Jian-Dong Huang
Kif5b controls the localization of myofibril components for their assembly and linkage to the myotendinous junctions.
Development (Cambridge, England) 2013;140(3):617-26.
2013: Qiuju Yuan; Wing Hin Chau; Jian-Dong Huang; Huanxing Su; Cheung Toa Ng; Wutian Wu; Zhi-Xiu Lin
Behavioral stress fails to accelerate the onset and progression of plaque pathology in the brain of a mouse model of Alzheimer's disease.
PloS one 2013;8(1):e53480.
2012: Xiongfei Fu; Jian-Dong Huang; Terence Hwa; Chenli Liu; Lei-Han Tang; Peter Lenz
Stripe formation in bacterial systems with density-suppressed motility.
Physical review letters 2012;108(19):198102.
2012: Tim Hon Man Chan; Leilei Chen; Liang Hu; Jian-Dong Huang; Pinzhu Huang; Ming Liu; Vincent Kwok-Man Poon; George Sai-wah Tsao; Jie Yang; Yun-Fei Yuan; Bo-Jian Zheng; Xin-Yuan Guan
Translationally controlled tumor protein induces mitotic defects and chromosome missegregation in hepatocellular carcinoma development.
Hepatology (Baltimore, Md.) 2012;55(2):491-505.
2012: Song-yue Zheng; Min Chen; Yan-Hong Hua; Rory Munro Watt; Bin Yu; Shuofeng Yuan; Kwok-Yung Yuen; Ke Zhang; Bo-Jian Zheng; Jian-Dong Huang
Comparative immunological evaluation of recombinant Salmonella Typhimurium strains expressing model antigens as live oral vaccines.
BMC immunology 2012;13():54.
2012: Hao Wu; Hui-fang Xu; Hao-Jie Zhang; Xiao-min Zhang; Jian-Dong Huang; Ming Wang; Bo-Jian Zheng
Identification of drug resistant mutations in HIV-1 CRF07_BC variants selected by nevirapine in vitro.
PloS one 2012;7(9):e44333.
2012: Mei Y Choi; Jian-Dong Huang; Bing-Tai Lu; Julian Tanner; Ying Wang; Wen-Yang Chen; Leo L Y Wong; Rory Munro Watt
The two PPX-GppA homologues from Mycobacterium tuberculosis have distinct biochemical activities.
PloS one 2012;7(8):e42561.
2012: Song Lu; Mai Har Sham; Qiu-Ju Yuan; Xin-Yuan Guan; Meng-Fei Liu; Lin-Yu Lu; Jian-Dong Huang
Cerebellar defects in Pdss2 conditional knockout mice during embryonic development and in adulthood.
Neurobiology of disease 2012;45(1):219-33.
2011: Chenli Liu; Lizhong Liu; Xiaojing Ren; Lei-Han Tang; Lu Xiang; Hualing Zeng; Carlos K L Chau; Guanhua Chen; Xiaodong Cui; Xiongfei Fu; Wei Huang; Terence Hwa; Peter Lenz; Sihong Li; Jian-Dong Huang
Sequential establishment of stripe patterns in an expanding cell population.
Science (New York, N.Y.) 2011;334(6053):238-41.
2011: Ye Jin; Jian-Dong Huang
Engineering a portable riboswitch-LacP hybrid device for two-way gene regulation.
Nucleic acids research 2011;39(19):e131.
2011: Bin Yu; Kwok-Yung Yuen; Bo-Jian Zheng; Erwei Song; Rory Munro Watt; Ho Yin Bosco Wong; Mei Yang; Jian-Dong Huang
A method to generate recombinant Salmonella typhi Ty21a strains expressing multiple heterologous genes using an improved recombineering strategy.
Applied microbiology and biotechnology 2011;91(1):177-88.
2011: Muhan Chen; Hong Kui Deng; Wen Deng; Suisui Dong; Jian-Dong Huang; Michael S Y Huen; Sze Lan Tsang; Tong Zan; Gui-Xia Zhu; Leilei Chen; Xin-Yuan Guan
Overexpression of eIF-5A2 in mice causes accelerated organismal aging by increasing chromosome instability.
BMC cancer 2011;11():199.
2011: Wen-yang Chen; John Ws Ho; Jian-Dong Huang; Rory Munro Watt
Functional characterization of an alkaline exonuclease and single strand annealing protein from the SXT genetic element of Vibrio cholerae.
BMC molecular biology 2011;12():16.
2011: Zai Wang; Jian-Dong Huang; Kin-Ling Wong; Pei-Gang Wang; Hao-Jie Zhang; Julian Tanner; ottavia spiga; Andrea Bernini; Bo-Jian Zheng; Neri Niccolai
On the mechanisms of bananin activity against severe acute respiratory syndrome coronavirus.
The FEBS journal 2011;278(2):383-9.
2011: Ju Cui; Zai Wang; Qianni Cheng; Raozhou Lin; Xin-Mei Zhang; Po Sing Leung; Neal G Copeland; Nancy A Jenkins; Kwok-Ming Yao; Jian-Dong Huang
Targeted inactivation of kinesin-1 in pancreatic β-cells in vivo leads to insulin secretory deficiency.
Diabetes 2011;60(1):320-30.
2010: liu yang; Wing Sum Hui; Wilson C W Chan; Vivian C W Ng; Teresa H Y Yam; Helen C M Leung; Jian-Dong Huang; Daisy K Y Shum; Qiang Jie; Kenneth M C Cheung; Kathryn S E Cheah; Zhoujing Luo; Danny Chan
A splice-site mutation leads to haploinsufficiency of EXT2 mRNA for a dominant trait in a large family with multiple osteochondromas.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2010;28(11):1522-30.
2010: Richard Y T Kao; Dan Yang; Lai-Shan Lau; Wayne H W Tsui; Lihong Hu; Jun Dai; Mei-Po Chan; Che-Man Chan; Pui Wang; Bo-Jian Zheng; Jian Sun; Jian-Dong Huang; Jason Madar; Guanhua Chen; Honglin Chen; Yi Guan; Kwok-Yung Yuen
Identification of influenza A nucleoprotein as an antiviral target.
Nature biotechnology 2010;28(6):600-5.
2010: Ding-Qiang Chen; Yong Zeng; Jie Zhou; Ling Yang; Shibo Jiang; Jian-Dong Huang; Liwei Lu; Bo-Jian Zheng
Association of candidate susceptible loci with chronic infection with hepatitis B virus in a Chinese population.
Journal of medical virology 2010;82(3):371-8.
2009: Jian-Dong Huang; Hong-Zhe Sun; Julian Tanner; Rory Munro Watt
Determination of the functions of the putative metal-binding domain of the SCV helicase.
Hong Kong medical journal = Xianggang yi xue za zhi / Hong Kong Academy of Medicine 2009;15 Suppl 6():15-6.
2009: Chenli Liu; Zai Wang; Michael S Y Huen; Lin-Yu Lu; De-Pei Liu; Jian-Dong Huang
Cell death caused by single-stranded oligodeoxynucleotide-mediated targeted genomic sequence modification.
Oligonucleotides 2009;19(3):281-6.
2009: Jie Zhou; Jian-Dong Huang; Vincent K M Poon; Ding-Qiang Chen; Chris C S Chan; Fai Ng; Xin-Yuan Guan; Rory Munro Watt; Liwei Lu; Kwok-Yung Yuen; Bo-Jian Zheng
Functional dissection of an IFN-alpha/beta receptor 1 promoter variant that confers higher risk to chronic hepatitis B virus infection.
Journal of hepatology 2009;51(2):322-32.
2009: Ming-Liang He; Bo-Jian Zheng; Ying Chen; Kin-Ling Wong; Jian-Dong Huang; Marie C M Lin; Kwok-Yung Yuen; J J Y Sung; Hsiang-Fu Kung
Development of interfering RNA agents to inhibit SARS-associated coronavirus infection and replication.
Hong Kong medical journal = Xianggang yi xue za zhi / Hong Kong Academy of Medicine 2009;15(3 Suppl 4):28-31.
2009: Jie Zhou; Ding-Qiang Chen; Vincent K M Poon; Yong Zeng; Fai Ng; Liwei Lu; Jian-Dong Huang; Kwok-Yung Yuen; Bo-Jian Zheng
A regulatory polymorphism in interferon-gamma receptor 1 promoter is associated with the susceptibility to chronic hepatitis B virus infection.
Immunogenetics 2009;61(6):423-30.
2009: Che-Man Chan; Herman Tse; S S Y Wong; P C Y Woo; S K P Lau; L Chen; Bo-Jian Zheng; Jian-Dong Huang; Kwok-Yung Yuen
Examination of seroprevalence of coronavirus HKU1 infection with S protein-based ELISA and neutralization assay against viral spike pseudotyped virus.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 2009;45(1):54-60.
2009: Patrick C Y Woo; Susanna K P Lau; Herman Tse; Jade L L Teng; Shirly O T Curreem; Alan K L Tsang; Rachel Y Y Fan; Gilman K M Wong; Yi Huang; Nicholas J Loman; Lori A S Snyder; James J Cai; Jian-Dong Huang; William Mak; Mark J Pallen; Si Lok; Kwok-Yung Yuen
The complete genome and proteome of Laribacter hongkongensis reveal potential mechanisms for adaptations to different temperatures and habitats.
PLoS genetics 2009;5(3):e1000416.
2009: Muhan Chen; Jian-Dong Huang; Liang Hu; Bo-Jian Zheng; Leilei Chen; Sze Lan Tsang; Xin-yuan Guan
Transgenic CHD1L expression in mouse induces spontaneous tumors.
PloS one 2009;4(8):e6727.
2009: Hong-Yan Sui; Guang-Yu Zhao; Jian-Dong Huang; Dong-Yan Jin; Kwok-Yung Yuen; Bo-Jian Zheng
Small interfering RNA targeting m2 gene induces effective and long term inhibition of influenza A virus replication.
PloS one 2009;4(5):e5671.
2009: Ye Jin; Rory Munro Watt; Antoine Danchin; Jian-Dong Huang
Small noncoding RNA GcvB is a novel regulator of acid resistance in Escherichia coli.
BMC genomics 2009;10():165.
2009: Che-Man Chan; Susanna K P Lau; Patrick C Y Woo; Herman Tse; Bo-Jian Zheng; Ling Chen; Jian-Dong Huang; Kwok-Yung Yuen
Identification of major histocompatibility complex class I C molecule as an attachment factor that facilitates coronavirus HKU1 spike-mediated infection.
Journal of virology 2009;83(2):1026-35.
2008: Che-Man Chan; Patrick C Y Woo; Susanna K P Lau; Herman Tse; Hong-Lin Chen; Feng Li; Bo-Jian Zheng; Ling Chen; Jian-Dong Huang; Kwok-Yung Yuen
Spike protein, S, of human coronavirus HKU1: role in viral life cycle and application in antibody detection.
Experimental biology and medicine (Maywood, N.J.) 2008;233(12):1527-36.
2008: Chi-Fung Choi; Jian-Dong Huang; Pui-Chi Lo; Wing-Ping Fong; Dennis K P Ng
Glycosylated zinc(II) phthalocyanines as efficient photosensitisers for photodynamic therapy. Synthesis, photophysical properties and in vitro photodynamic activity.
Organic & biomolecular chemistry 2008;6(12):2173-81.
2008: Zhi Li; Hong Yao; Yan Ma; Qingming Dong; Yangchao Chen; Ying Peng; Bo-Jian Zheng; Jian-Dong Huang; Chu-yan Chan; Marie C Lin; Joseph J Sung; Kwok Yun Yuen; Hsiang-Fu Kung; Ming-Liang He
Inhibition of HBV gene expression and replication by stably expressed interferon-alpha1 via adeno-associated viral vectors.
The journal of gene medicine 2008;10(6):619-27.
2008: Lin-Yu Lu; Michael S Y Huen; Andrew Chi-Pang Tai; De-Pei Liu; Kathryn S E Cheah; Jian-Dong Huang
Highly efficient deletion method for the engineering of plasmid DNA with single-stranded oligonucleotides.
BioTechniques 2008;44(2):217-20, 222, 224.
2008: Zai Wang; Zhong-Jun Zhou; De-Pei Liu; Jian-Dong Huang
Double-stranded break can be repaired by single-stranded oligonucleotides via the ATM/ATR pathway in mammalian cells.
Oligonucleotides 2008;18(1):21-32.
2007: Nan Yang; Julian Tanner; Zai Wang; Jian-Dong Huang; Bo-Jian Zheng; Nianyong Zhu; Hongzhe Sun
Inhibition of SARS coronavirus helicase by bismuth complexes.
Chemical communications (Cambridge, England) 2007;(42):4413-5.
2007: Ruiguang Ge; Xuesong Sun; Qing Gu; Rory Munro Watt; Julian Tanner; Benjamin Chun-Yu Wong; Harry Huaxiang Xia; Jian-Dong Huang; Qing-Yu He; Hongzhe Sun
A proteomic approach for the identification of bismuth-binding proteins in Helicobacter pylori.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2007;12(6):831-42.
2007: Michael S Y Huen; Lin-Yu Lu; De-Pei Liu; Jian-Dong Huang
Active transcription promotes single-stranded oligonucleotide mediated gene repair.
Biochemical and biophysical research communications 2007;353(1):33-9.
2007: Nan Yang; Julian Tanner; Bo-Jian Zheng; Rory Munro Watt; Ming-Liang He; Lin-Yu Lu; Jie-Qing Jiang; Ka-To Shum; Yong-Ping Lin; Kin-Ling Wong; Marie C M Lin; Hsiang-Fu Kung; Hongzhe Sun; Jian-Dong Huang
Bismuth complexes inhibit the SARS coronavirus.
Angewandte Chemie (International ed. in English) 2007;46(34):6464-8.
2007: Rory Munro Watt; Jing Wang; Meikid Leong; Hsiang-Fu Kung; Kathryn S E Cheah; Depei Liu; Antoine Danchin; Jian-Dong Huang
Visualizing the proteome of Escherichia coli: an efficient and versatile method for labeling chromosomal coding DNA sequences (CDSs) with fluorescent protein genes.
Nucleic acids research 2007;35(6):e37.
2006: Zai Wang; Zhong-Jun Zhou; De-Pei Liu; Jian-Dong Huang
Single-stranded oligonucleotide-mediated gene repair in mammalian cells has a mechanism distinct from homologous recombination repair.
Biochemical and biophysical research communications 2006;350(3):568-73.
2006: Lanying Du; Yuxian He; Yijia Wang; Haojie Zhang; Selene Ma; Charlotte K L Wong; Sharon H W Wu; Fai Ng; Jian-Dong Huang; Kwok-Yung Yuen; Shibo Jiang; Yusen Zhou; Bo-Jian Zheng
Recombinant adeno-associated virus expressing the receptor-binding domain of severe acute respiratory syndrome coronavirus S protein elicits neutralizing antibodies: Implication for developing SARS vaccines.
Virology 2006;353(1):6-16.
2006: Ruiguang Ge; Yi Zhang; Xuesong Sun; Rory Munro Watt; Qing-Yu He; Jian-Dong Huang; Dean E Wilcox; Hongzhe Sun
Thermodynamic and kinetic aspects of metal binding to the histidine-rich protein, Hpn.
Journal of the American Chemical Society 2006;128(35):11330-1.
2006: Ming-Liang He; Bo-Jian Zheng; Ying Chen; Kin-Ling Wong; Jian-Dong Huang; Marie C Lin; Ying Peng; Kwok Y Yuen; Joseph J Y Sung; Hsiang-Fu Kung
Kinetics and synergistic effects of siRNAs targeting structural and replicase genes of SARS-associated coronavirus.
FEBS letters 2006;580(10):2414-20.
2006: Michael S Y Huen; Xin-tian Li; Lin-Yu Lu; Rory Munro Watt; De-Pei Liu; Jian-Dong Huang
The involvement of replication in single stranded oligonucleotide-mediated gene repair.
Nucleic acids research 2006;34(21):6183-94.
2006: Ruiguang Ge; Rory Munro Watt; Xuesong Sun; Julian Tanner; Qing-Yu He; Jian-Dong Huang; Hongzhe Sun
Expression and characterization of a histidine-rich protein, Hpn: potential for Ni2+ storage in Helicobacter pylori.
The Biochemical journal 2006;393(Pt 1):285-93.
2005: Xin-Mei Zhang; Bai-Yu Chen; Alam Hoi-Lam Ng; Julian Tanner; David Tay; Kwok-Fai So; Rivka Rachel; Neal G Copeland; Nancy A Jenkins; Jian-Dong Huang
Transgenic mice expressing Cre-recombinase specifically in retinal rod bipolar neurons.
Investigative ophthalmology & visual science 2005;46(10):3515-20.
2005: Wen-Xuan Yin; Xue-Song Wu; Guang Liu; Zhu-Hong Li; Rory Munro Watt; Jian-Dong Huang; De-Pei Liu; Chih-Chuan Liang
Targeted correction of a chromosomal point mutation by modified single-stranded oligonucleotides in a GFP recovery system.
Biochemical and biophysical research communications 2005;334(4):1032-41.
2005: Baohua Liu; Jianming Wang; Kui Ming Chan; Wai Mui Tjia; Wen Deng; Xinyuan Guan; Jian-Dong Huang; Kai Man Li; Pui Yin Chau; David J Chen; Duanqing Pei; Alberto Pendas; Juan Cadiñanos; Carlos López-Otín; Hung-Fat Tse; Chris Hutchison; Junjie Chen; Yihai Cao; Kathryn S E Cheah; Karl Tryggvason; Zhongjun Zhou
Genomic instability in laminopathy-based premature aging.
Nature medicine 2005;11(7):780-5.
2005: Julian Tanner; Bo-Jian Zheng; Jie Zhou; Rory Munro Watt; Jie-Qing Jiang; Kin-Ling Wong; Yong-Ping Lin; Lin-Yu Lu; Ming-Liang He; Hsiang-Fu Kung; Andreas J Kesel; Jian-Dong Huang
The adamantane-derived bananins are potent inhibitors of the helicase activities and replication of SARS coronavirus.
Chemistry & biology 2005;12(3):303-11.
2005: Xue-Song Wu; Li Xin; Wen-Xuan Yin; Xi-Ying Shang; Lu Lu; Rory Munro Watt; Kathryn S E Cheah; Jian-Dong Huang; De-Pei Liu; Chih-Chuan Liang
Increased efficiency of oligonucleotide-mediated gene repair through slowing replication fork progression.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(7):2508-13.
2005: Bo-Jian Zheng; Yi Guan; Ming-Liang Hez; Hongzhe Sun; Lanying Du; Ying Zheng; Kin-Ling Wong; Honglin Chen; Ying Chen; Linyu Lu; Julian Tanner; Rory Munro Watt; Neri Niccolai; Andrea Bernini; ottavia spiga; Patrick C Y Woo; Hsiang-Fu Kung; Kwok-Yung Yuen; Jian-Dong Huang
Synthetic peptides outside the spike protein heptad repeat regions as potent inhibitors of SARS-associated coronavirus.
Antiviral therapy 2005;10(3):393-403.
2005: Queenie N Y Wong; Vivian C W Ng; Marie C M Lin; Hsiang-Fu Kung; Danny Chan; Jian-Dong Huang
Efficient and seamless DNA recombineering using a thymidylate synthase A selection system in Escherichia coli.
Nucleic acids research 2005;33(6):e59.
2004: T Norene O'Sullivan; Xufeng S Wu; Rivka Rachel; Jian-Dong Huang; Deborah A Swing; Lydia E Matesic; John A Hammer; Neal G Copeland; Nancy A Jenkins
dsu functions in a MYO5A-independent pathway to suppress the coat color of dilute mice.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(48):16831-6.
2004: Richard Y T Kao; Wayne H W Tsui; Terri S W Lee; Julian Tanner; Rory Munro Watt; Jian-Dong Huang; Lihong Hu; Guanhua Chen; Zhiwei Chen; Linqi Zhang; Tian He; Kwok-Hung Chan; Herman Tse; Amanda P C To; Louisa W Y Ng; Bonnie C W Wong; Hoi-Wah Tsoi; Dan Yang; David D Ho; Kwok-Yung Yuen
Identification of novel small-molecule inhibitors of severe acute respiratory syndrome-associated coronavirus by chemical genetics.
Chemistry & biology 2004;11(9):1293-9.
2004: Xin-Mei Zhang; Alam Hoi-Lam Ng; Julian Tanner; Wu-Tian Wu; Neal G Copeland; Nancy A Jenkins; Jian-Dong Huang
Highly restricted expression of Cre recombinase in cerebellar Purkinje cells.
Genesis (New York, N.Y. : 2000) 2004;40(1):45-51.
2003: Xin-tian Li; Nina Costantino; Lin-Yu Lu; De-Pei Liu; Rory Munro Watt; Kathryn S E Cheah; Donald L Court; Jian-Dong Huang
Identification of factors influencing strand bias in oligonucleotide-mediated recombination in Escherichia coli.
Nucleic acids research 2003;31(22):6674-87.
2003: Julian Tanner; Rory Munro Watt; Yu-Bo Chai; Lin-Yu Lu; Marie C Lin; J S M Peiris; Leo Poon; Hsiang-Fu Kung; Jian-Dong Huang
The severe acute respiratory syndrome (SARS) coronavirus NTPase/helicase belongs to a distinct class of 5' to 3' viral helicases.
The Journal of biological chemistry 2003;278(41):39578-82.
2003: Xin-Mei Zhang; Jian-Dong Huang
Combination of overlapping bacterial artificial chromosomes by a two-step recombinogenic engineering method.
Nucleic acids research 2003;31(15):e81.
2002: Josephine Sui-Yan Au; Jian-Dong Huang
A tissue-specific exon of myosin Va is responsible for selective cargo binding in melanocytes.
Cell motility and the cytoskeleton 2002;53(2):89-102.