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Kun Huang

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Lipoylation

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Maria Fairbank; Kun Huang; Alaa El-Husseini; Ivan R Nabi
RING finger palmitoylation of the endoplasmic reticulum Gp78 E3 ubiquitin ligase.
Fiona B Young; Weining Zhang; Nagat Bissada; Yu Deng; Sonia Franciosi; Kun Huang; Chris Kay; Shaun Sanders; Roshni R Singaraja; Amanda Spreeuw; Natalie C M Tam; Michael R Hayden
Low levels of human HIP14 are sufficient to rescue neuropathological, behavioural, and enzymatic defects due to loss of murine HIP14 in Hip14-/- mice.
Roshni R Singaraja; Kuljeet Vaid; Junmei Wan; Fiona B Young; Nagat Bissada; Nicholas G Davis; Crystal Doty; Renaldo C Drisdel; Sonia Franciosi; William N Green; R Mark Henkelman; Rochelle Hines; Kun Huang; Jason P Lerch; Austen J Milnerwood; Lynn A Raymond; Shaun S Sanders; Michael R Hayden
Altered palmitoylation and neuropathological deficits in mice lacking HIP14.

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All Publications

2012: Maria Fairbank; Kun Huang; Alaa El-Husseini; Ivan R Nabi
RING finger palmitoylation of the endoplasmic reticulum Gp78 E3 ubiquitin ligase.
FEBS letters 2012;586(16):2488-93.
2012: Fiona B Young; Weining Zhang; Nagat Bissada; Yu Deng; Sonia Franciosi; Kun Huang; Chris Kay; Shaun Sanders; Roshni R Singaraja; Amanda Spreeuw; Natalie C M Tam; Michael R Hayden
Low levels of human HIP14 are sufficient to rescue neuropathological, behavioural, and enzymatic defects due to loss of murine HIP14 in Hip14-/- mice.
PloS one 2012;7(5):e36315.
2011: Roshni R Singaraja; Kuljeet Vaid; Junmei Wan; Fiona B Young; Nagat Bissada; Nicholas G Davis; Crystal Doty; Renaldo C Drisdel; Sonia Franciosi; William N Green; R Mark Henkelman; Rochelle Hines; Kun Huang; Jason P Lerch; Austen J Milnerwood; Lynn A Raymond; Shaun S Sanders; Michael R Hayden
Altered palmitoylation and neuropathological deficits in mice lacking HIP14.
Human molecular genetics 2011;20(20):3899-909.
2011: Pamela Arstikaitis; Catherine Gauthier-Campbell; Kun Huang; Alaa El-Husseini; Timothy H Murphy
Proteins that promote filopodia stability, but not number, lead to more axonal-dendritic contacts.
PloS one 2011;6(3):e16998.
2010: Kun Huang; Martin H Kang; Caitlin Askew; Rujun Kang; Shaun S Sanders; Junmei Wan; Nicholas G Davis; Michael R Hayden
Palmitoylation and function of glial glutamate transporter-1 is reduced in the YAC128 mouse model of Huntington disease.
Neurobiology of disease 2010;40(1):207-15.
2009: Kun Huang; Shaun Sanders; Roshni R Singaraja; Paul Orban; Tony Cijsouw; Pamela Arstikaitis; Anat Yanai; Michael R Hayden; Alaa El-Husseini
Neuronal palmitoyl acyl transferases exhibit distinct substrate specificity.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009;23(8):2605-15.
2008: Daria Krivosheya; Lucia Tapia; Joshua N Levinson; Kun Huang; Yunhee Kang; Rochelle Hines; Annie K Ting; Ann Marie Craig; Lin Mei; shernaz bamji; Alaa El-Husseini
ErbB4-neuregulin signaling modulates synapse development and dendritic arborization through distinct mechanisms.
The Journal of biological chemistry 2008;283(47):32944-56.
2008: Pamela Arstikaitis; Catherine Gauthier-Campbell; Rosario Carolina Gutierrez Herrera; Kun Huang; Joshua N Levinson; Timothy H Murphy; Manfred W Kilimann; Carlo Sala; Michael A Colicos; Alaa El-Husseini
Paralemmin-1, a modulator of filopodia induction is required for spine maturation.
Molecular biology of the cell 2008;19(5):2026-38.
2006: Anat Yanai; Kun Huang; Rujun Kang; Roshni R Singaraja; Pamela Arstikaitis; Lu Gan; Paul C Orban; Asher Mullard; Catherine M Cowan; Lynn A Raymond; Renaldo C Drisdel; William N Green; Brinda Ravikumar; David C Rubinsztein; Alaa El-Husseini; Michael R Hayden
Palmitoylation of huntingtin by HIP14 is essential for its trafficking and function.
Nature neuroscience 2006;9(6):824-31.
2005: Kun Huang; Alaa El-Husseini
Modulation of neuronal protein trafficking and function by palmitoylation.
Current opinion in neurobiology 2005;15(5):527-35.
2005: Joshua N Levinson; Nadège Chéry; Kun Huang; Tak Pan Wong; Kimberly Gerrow; Rujun Kang; Oliver Prange; Yu Tian Wang; Alaa El-Husseini
Neuroligins mediate excitatory and inhibitory synapse formation: involvement of PSD-95 and neurexin-1beta in neuroligin-induced synaptic specificity.
The Journal of biological chemistry 2005;280(17):17312-9.
2004: Kun Huang; Anat Yanai; Rujun Kang; Pamela Arstikaitis; Roshni R Singaraja; Martina Metzler; Asher Mullard; Brendan Haigh; Catherine Gauthier-Campbell; Claire-Anne Gutekunst; Michael R Hayden; Alaa El-Husseini
Huntingtin-interacting protein HIP14 is a palmitoyl transferase involved in palmitoylation and trafficking of multiple neuronal proteins.
Neuron 2004;44(6):977-86.