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Xiaodong Huang

Research Profile

Disorders

Leukemia L1210

Chemicals & Drugs

Physiology

Anatomy

Tumor Cells, Cultured

Concepts & Ideas

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Publications

TOP 3
Duy H Hua; Xiaodong Huang; Yi Chen; Srinivas K Battina; Masafumi Tamura; Sang K Noh; Sung I Koo; Ichiji Namatame; Hiroshi Tomoda; Elisabeth M Perchellet; Jean-Pierre H Perchellet
Total syntheses of (+)-chloropuupehenone and (+)-chloropuupehenol and their analogues and evaluation of their bioactivities.
Elisabeth M Perchellet; Bonnie J Sperfslage; Yang Wang; Xiaodong Huang; Masafumi Tamura; Duy H Hua; Jean-Pierre H Perchellet
Among substituted 9,10-dihydro-9,10-[1,2]benzenoanthracene-1,4,5,8-tetraones, the lead antitumor triptycene bisquinone TT24 blocks nucleoside transport, induces apoptotic DNA fragmentation and decreases the viability of L1210 leukemic cells in the nanomolar range of daunorubicin in vitro.
Duy H Hua; Masafumi Tamura; Xiaodong Huang; Heidi A Stephany; Brian A Helfrich; Elisabeth M Perchellet; Bonnie J Sperfslage; Jean-Pierre H Perchellet; Suping Jiang; Dennis E Kyle; Peter K Chiang
Syntheses and bioactivities of substituted 9,10-dihydro-9,10-[1,2]benzenoanthracene-1,4,5,8-tetrones. Unusual reactivities with amines.

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All Publications

2004: Duy H Hua; Xiaodong Huang; Yi Chen; Srinivas K Battina; Masafumi Tamura; Sang K Noh; Sung I Koo; Ichiji Namatame; Hiroshi Tomoda; Elisabeth M Perchellet; Jean-Pierre H Perchellet
Total syntheses of (+)-chloropuupehenone and (+)-chloropuupehenol and their analogues and evaluation of their bioactivities.
The Journal of organic chemistry 2004;69(18):6065-78.
2002: Elisabeth M Perchellet; Bonnie J Sperfslage; Yang Wang; Xiaodong Huang; Masafumi Tamura; Duy H Hua; Jean-Pierre H Perchellet
Among substituted 9,10-dihydro-9,10-[1,2]benzenoanthracene-1,4,5,8-tetraones, the lead antitumor triptycene bisquinone TT24 blocks nucleoside transport, induces apoptotic DNA fragmentation and decreases the viability of L1210 leukemic cells in the nanomolar range of daunorubicin in vitro.
Anti-cancer drugs 2002;13(6):567-81.
2002: Duy H Hua; Masafumi Tamura; Xiaodong Huang; Heidi A Stephany; Brian A Helfrich; Elisabeth M Perchellet; Bonnie J Sperfslage; Jean-Pierre H Perchellet; Suping Jiang; Dennis E Kyle; Peter K Chiang
Syntheses and bioactivities of substituted 9,10-dihydro-9,10-[1,2]benzenoanthracene-1,4,5,8-tetrones. Unusual reactivities with amines.
The Journal of organic chemistry 2002;67(9):2907-12.
2001: Buna Wang; M Wu; Elisabeth M Perchellet; Corbin J McIlvain; Bonnie J Sperfslage; Xiaodong Huang; Masafumi Tamura; Heidi A Stephany; Duy H Hua; Jean-Pierre H Perchellet
A synthetic triptycene bisquinone, which blocks nucleoside transport and induces DNA fragmentation, retains its cytotoxic efficacy in daunorubicin-resistant HL-60 cell lines.
International journal of oncology 2001;19(6):1169-78.
2000: Elisabeth M Perchellet; MJ Magill; Xiaodong Huang; D M Dalke; Duy H Hua; Jean-Pierre H Perchellet
1,4-Anthraquinone: an anticancer drug that blocks nucleoside transport, inhibits macromolecule synthesis, induces DNA fragmentation, and decreases the growth and viability of L1210 leukemic cells in the same nanomolar range as daunorubicin in vitro.
Anti-cancer drugs 2000;11(5):339-52.
1999: Elisabeth M Perchellet; MJ Magill; Xiaodong Huang; C E Brantis; Duy H Hua; Jean-Pierre H Perchellet
Triptycenes: a novel synthetic class of bifunctional anticancer drugs that inhibit nucleoside transport, induce DNA cleavage and decrease the viability of leukemic cells in the nanomolar range in vitro.
Anti-cancer drugs 1999;10(8):749-66.
1998: Xiaodong Huang; R Xu; M D Hawley; TL Hopkins; Karl J Kramer
Electrochemical oxidation of N-acyldopamines and regioselective reactions of their quinones with N-acetylcysteine and thiourea.
Archives of biochemistry and biophysics 1998;352(1):19-30.
1996: R Xu; Xiaodong Huang; T D Morgan; O Prakash; Karl J Kramer; M D Hawley
Characterization of products from the reactions of N-acetyldopamine quinone with N-acetylhistidine.
Archives of biochemistry and biophysics 1996;329(1):56-64.
1995: R Xu; Xiaodong Huang; Karl J Kramer; M D Hawley
On-column reduction of catecholamine quinones in stainless steel columns during liquid chromatography.
Analytical biochemistry 1995;231(1):72-81.