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Yadong Huang
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Chemicals & Drugs
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Network (preview)
29
Mahley, Robert
9
Weisgraber, Karl
8
Xu, Qin
7
Rall, SC
7
Brecht, Walter
5
Wyss-Coray, Tony
4
Harris, Faith
4
Ji, Zhong-Sheng
4
Mucke, Lennart
4
Tesseur, Ina C.
3
Taylor, John
3
Williamson, David
3
Balestra, Maureen
3
Miranda, Dennis
3
Sanan, David
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Publications
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Geonetwork of Yadong Huang (preview)
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All Publications
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2009: Tesseur Ina; Zhang Hui; Brecht Walter; Corn Jacob; Gong Jian-Sheng; Yanagisawa Katsuhiko; Michikawa Makoto; Weisgraber Karl; Huang Yadong; Wyss-Coray Tony
Bioactive TGF-beta can associate with lipoproteins and is enriched in those containing apolipoprotein E3.
Journal of neurochemistry 2009;110(4):1254-62.
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2009: Mahley Robert W; Weisgraber Karl H; Huang Yadong
Apolipoprotein E: structure determines function, from atherosclerosis to Alzheimer's disease to AIDS.
Journal of lipid research 2009;50 Suppl():S183-8.
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2008: Burt Trevor D; Agan Brian K; Marconi Vincent C; He Weijing; Kulkarni Hemant; Mold Jeffrey E; Cavrois Marielle; Huang Yadong; Mahley Robert W; Dolan Matthew J; McCune Joseph M; Ahuja Sunil K
Apolipoprotein (apo) E4 enhances HIV-1 cell entry in vitro, and the APOE epsilon4/epsilon4 genotype accelerates HIV disease progression.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(25):8718-23.
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2008: Xu Qin; Walker David; Bernardo Aubrey; Brodbeck Jens; Balestra Maureen E; Huang Yadong
Intron-3 retention/splicing controls neuronal expression of apolipoprotein E in the CNS.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(6):1452-9.
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2008: Brodbeck Jens; Balestra Maureen E; Saunders Ann M; Roses Allen D; Mahley Robert W; Huang Yadong
Rosiglitazone increases dendritic spine density and rescues spine loss caused by apolipoprotein E4 in primary cortical neurons.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(4):1343-6.
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2006: Huang Yadong
Molecular and cellular mechanisms of apolipoprotein E4 neurotoxicity and potential therapeutic strategies.
Current opinion in drug discovery & development 2006;9(5):627-41.
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2006: Xu Qin; Bernardo Aubrey; Walker David; Kanegawa Tiffany; Mahley Robert W; Huang Yadong
Profile and regulation of apolipoprotein E (ApoE) expression in the CNS in mice with targeting of green fluorescent protein gene to the ApoE locus.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(19):4985-94.
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2006: Huang Yadong; Mahley Robert W
Commentary on "Perspective on a pathogenesis and treatment of Alzheimer's disease." Apolipoprotein E and the mitochondrial metabolic hypothesis.
Alzheimer's & dementia : the journal of the Alzheimer's Association 2006;2(2):71-3.
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2006: Mahley Robert W; Weisgraber Karl H; Huang Yadong
Apolipoprotein E4: a causative factor and therapeutic target in neuropathology, including Alzheimer's disease.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(15):5644-51.
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2006: Ji Zhong-Sheng; Müllendorff Karin; Cheng Irene H; Miranda R Dennis; Huang Yadong; Mahley Robert W
Reactivity of apolipoprotein E4 and amyloid beta peptide: lysosomal stability and neurodegeneration.
The Journal of biological chemistry 2006;281(5):2683-92.
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2006: Huang Yadong
Apolipoprotein E and Alzheimer disease.
Neurology 2006;66(2 Suppl 1):S79-85.
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2006: Hodoglugil Ugur; Tanyolaç Sinan; Williamson David W; Huang Yadong; Mahley Robert W
Apolipoprotein A-V: a potential modulator of plasma triglyceride levels in Turks.
Journal of lipid research 2006;47(1):144-53.
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2006: Mahley R W; Huang Y
Apolipoprotein (apo) E4 and Alzheimer's disease: unique conformational and biophysical properties of apoE4 can modulate neuropathology.
Acta neurologica Scandinavica. Supplementum 2006;185():8-14.
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2005: Chang Shengjun; ran Ma Tian; Miranda R Dennis; Balestra Maureen E; Mahley Robert W; Huang Yadong
Lipid- and receptor-binding regions of apolipoprotein E4 fragments act in concert to cause mitochondrial dysfunction and neurotoxicity.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(51):18694-9.
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2005: Ye Shiming; Huang Yadong; Müllendorff Karin; Dong Liming; Giedt Gretchen; Meng Elaine C; Cohen Fred E; Kuntz Irwin D; Weisgraber Karl H; Mahley Robert W
Apolipoprotein (apo) E4 enhances amyloid beta peptide production in cultured neuronal cells: apoE structure as a potential therapeutic target.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(51):18700-5.
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2005: Hodoglugil Ugur; Williamson David W; Huang Yadong; Mahley Robert W
Common polymorphisms of ATP binding cassette transporter A1, including a functional promoter polymorphism, associated with plasma high density lipoprotein cholesterol levels in Turks.
Atherosclerosis 2005;183(2):199-212.
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2005: Ramaswamy Gayathri; Xu Qin; Huang Yadong; Weisgraber Karl H
Effect of domain interaction on apolipoprotein E levels in mouse brain.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(46):10658-63.
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2005: Hodoglugil U; Williamson D W; Huang Y; Mahley R W
An interaction between the TaqIB polymorphism of cholesterol ester transfer protein and smoking is associated with changes in plasma high-density lipoprotein cholesterol levels in Turks.
Clinical genetics 2005;68(2):118-27.
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2004: Harris Faith M; Brecht Walter J; Xu Qin; Mahley Robert W; Huang Yadong
Increased tau phosphorylation in apolipoprotein E4 transgenic mice is associated with activation of extracellular signal-regulated kinase: modulation by zinc.
The Journal of biological chemistry 2004;279(43):44795-801.
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2004: Xu Qin; Brecht Walter J; Weisgraber Karl H; Mahley Robert W; Huang Yadong
Apolipoprotein E4 domain interaction occurs in living neuronal cells as determined by fluorescence resonance energy transfer.
The Journal of biological chemistry 2004;279(24):25511-6.
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2004: Brecht Walter J; Harris Faith M; Chang Shengjun; Tesseur Ina; Yu Gui-Qiu; Xu Qin; Dee Fish Jo; Wyss-Coray Tony; Buttini Manuel; Mucke Lennart; Mahley Robert W; Huang Yadong
Neuron-specific apolipoprotein e4 proteolysis is associated with increased tau phosphorylation in brains of transgenic mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(10):2527-34.
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2004: Harris Faith M; Tesseur Ina; Brecht Walter J; Xu Qin; Mullendorff Karin; Chang Shengjun; Wyss-Coray Tony; Mahley Robert W; Huang Yadong
Astroglial regulation of apolipoprotein E expression in neuronal cells. Implications for Alzheimer's disease.
The Journal of biological chemistry 2004;279(5):3862-8.
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2004: Huang Yadong; Weisgraber Karl H; Mucke Lennart; Mahley Robert W
Apolipoprotein E: diversity of cellular origins, structural and biophysical properties, and effects in Alzheimer's disease.
Journal of molecular neuroscience : MN 2004;23(3):189-204.
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2003: Harris Faith M; Brecht Walter J; Xu Qin; Tesseur Ina; Kekonius Lisa; Wyss-Coray Tony; Fish Jo Dee; Masliah Eliezer; Hopkins Paul C; Scearce-Levie Kimberly; Weisgraber Karl H; Mucke Lennart; Mahley Robert W; Huang Yadong
Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimer's disease-like neurodegeneration and behavioral deficits in transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(19):10966-71.
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2002: Buttini Manuel; Yu Gui-Qiu; Shockley Kristina; Huang Yadong; Jones Brian; Masliah Eliezer; Mallory Margaret; Yeo Tracy; Longo Frank M; Mucke Lennart
Modulation of Alzheimer-like synaptic and cholinergic deficits in transgenic mice by human apolipoprotein E depends on isoform, aging, and overexpression of amyloid beta peptides but not on plaque formation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(24):10539-48.
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2002: Hopkins Paul C R; Huang Yadong; McGuire James G; Pitas Robert E
Evidence for differential effects of apoE3 and apoE4 on HDL metabolism.
Journal of lipid research 2002;43(11):1881-9.
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2002: Ji Zhong-Sheng; Miranda R Dennis; Newhouse Yvonne M; Weisgraber Karl H; Huang Yadong; Mahley Robert W
Apolipoprotein E4 potentiates amyloid beta peptide-induced lysosomal leakage and apoptosis in neuronal cells.
The Journal of biological chemistry 2002;277(24):21821-8.
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2001: Huang Y; Liu X Q; Wyss-Coray T; Brecht W J; Sanan D A; Mahley R W
Apolipoprotein E fragments present in Alzheimer's disease brains induce neurofibrillary tangle-like intracellular inclusions in neurons.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(15):8838-43.
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1999: Huang Y; Ji Z S; Brecht W J; Rall S C; Taylor J M; Mahley R W
Overexpression of apolipoprotein E3 in transgenic rabbits causes combined hyperlipidemia by stimulating hepatic VLDL production and impairing VLDL lipolysis.
Arteriosclerosis, thrombosis, and vascular biology 1999;19(12):2952-9.
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1999: Mahley R W; Huang Y; Rall S C
Pathogenesis of type III hyperlipoproteinemia (dysbetalipoproteinemia). Questions, quandaries, and paradoxes.
Journal of lipid research 1999;40(11):1933-49.
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1998: Huang Y; Liu X Q; Rall S C; Taylor J M; von Eckardstein A; Assmann G; Mahley R W
Overexpression and accumulation of apolipoprotein E as a cause of hypertriglyceridemia.
The Journal of biological chemistry 1998;273(41):26388-93.
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1998: Huang Y; Liu X Q; Rall S C; Mahley R W
Apolipoprotein E2 reduces the low density lipoprotein level in transgenic mice by impairing lipoprotein lipase-mediated lipolysis of triglyceride-rich lipoproteins.
The Journal of biological chemistry 1998;273(28):17483-90.
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1998: Fan J; Ji Z S; Huang Y; de Silva H; Sanan D; Mahley R W; Innerarity T L; Taylor J M
Increased expression of apolipoprotein E in transgenic rabbits results in reduced levels of very low density lipoproteins and an accumulation of low density lipoproteins in plasma.
The Journal of clinical investigation 1998;101(10):2151-64.
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1997: Huang Y; Rall S C; Mahley R W
Genetic factors precipitating type III hyperlipoproteinemia in hypolipidemic transgenic mice expressing human apolipoprotein E2.
Arteriosclerosis, thrombosis, and vascular biology 1997;17(11):2817-24.
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1997: Huang Y; Schwendner S W; Rall S C; Sanan D A; Mahley R W
Apolipoprotein E2 transgenic rabbits. Modulation of the type III hyperlipoproteinemic phenotype by estrogen and occurrence of spontaneous atherosclerosis.
The Journal of biological chemistry 1997;272(36):22685-94.
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1996: Huang Y; Schwendner S W; Rall S C; Mahley R W
Hypolipidemic and hyperlipidemic phenotypes in transgenic mice expressing human apolipoprotein E2.
The Journal of biological chemistry 1996;271(46):29146-51.
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