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Yadong Huang

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Chemicals & Drugs

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Alzheimer's Disease

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Publications

TOP 3
Sachi Jain; Johanna Knoferle; Laura Leung; Seo Yeon Yoon; Yadong Huang
Cellular source-specific effects of apolipoprotein (apo) E4 on dendrite arborization and dendritic spine development.
Robert W Mahley; Yadong Huang
Apolipoprotein e sets the stage: response to injury triggers neuropathology.
Karen L Ring; Leslie M Tong; David Walker; William R Zhang; Yaisa Andrews-Zwilling; Maureen E Balestra; Robyn Javier; Anatol C Kreitzer; Gang Li; Yadong Huang
Direct reprogramming of mouse and human fibroblasts into multipotent neural stem cells with a single factor.

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All Publications

2013: Sachi Jain; Johanna Knoferle; Laura Leung; Seo Yeon Yoon; Yadong Huang
Cellular source-specific effects of apolipoprotein (apo) E4 on dendrite arborization and dendritic spine development.
PloS one 2013;8(3):e59478.
2012: Robert W Mahley; Yadong Huang
Apolipoprotein e sets the stage: response to injury triggers neuropathology.
Neuron 2012;76(5):871-85.
2012: Karen L Ring; Leslie M Tong; David Walker; William R Zhang; Yaisa Andrews-Zwilling; Maureen E Balestra; Robyn Javier; Anatol C Kreitzer; Gang Li; Yadong Huang
Direct reprogramming of mouse and human fibroblasts into multipotent neural stem cells with a single factor.
Cell stem cell 2012;11(1):100-9.
2012: Nga Bien-Ly; Anna K Gillespie; David Walker; Seo Yeon Yoon; Yadong Huang
Reducing human apolipoprotein E levels attenuates age-dependent Aβ accumulation in mutant human amyloid precursor protein transgenic mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(14):4803-11.
2012: Yadong Huang; Lennart Mucke
Alzheimer mechanisms and therapeutic strategies.
Cell 2012;148(6):1204-22.
2012: Hung-Kai Chen; Stephen B Freedman; Yadong Huang; Dah-eun Jeong; Zhong-Sheng Ji; Zhaoping Liu; Maureen E Balestra; Jens Brodbeck; Madhu S Budamagunta; James G McGuire; Anke Meyer-Franke; R Dennis Miranda; Michael A Pleiss; John C Voss; David W Walker; Karl H Weisgraber; Qin Xu; Robert W Mahley
Small molecule structure correctors abolish detrimental effects of apolipoprotein E4 in cultured neurons.
The Journal of biological chemistry 2012;287(8):5253-66.
2012: Laura Leung; Karen Ring; Leslie Tong; David Walker; Max Mu Wang; Seo Yeon Yoon; Yaisa Andrews-Zwilling; Jessica Dai; Sachi Jain; Yadong Huang
Apolipoprotein E4 causes age- and sex-dependent impairments of hilar GABAergic interneurons and learning and memory deficits in mice.
PloS one 2012;7(12):e53569.
2012: Sachi Jain; David Walker; Seo Yeon Yoon; Lei Zhu; Jens Brodbeck; Jessica Dai; Yadong Huang
Arf4 determines dentate gyrus-mediated pattern separation by regulating dendritic spine development.
PloS one 2012;7(9):e46340.
2012: Yaisa Andrews-Zwilling; Nga Bien-Ly; Nino Devidze; Anna K Gillespie; Alexxai V Kravitz; Anatol C Kreitzer; Iris Lo; Alexandra B Nelson; Gregory B Potter; Karen Ring; John L R Rubenstein; Seo Yeon Yoon; Daniel Zwilling; Yadong Huang
Hilar GABAergic interneuron activity controls spatial learning and memory retrieval.
PloS one 2012;7(7):e40555.
2011: Yadong Huang
Roles of apolipoprotein E4 (ApoE4) in the pathogenesis of Alzheimer's disease: lessons from ApoE mouse models.
Biochemical Society transactions 2011;39(4):924-32.
2011: Daniel Zwilling; Anthony Adame; Yaisa Andrews-Zwilling; Gunnar Flik; Flaviano Giorgini; Paolo Guidetti; Eric W Hsieh; Shao-Yi Huang; Yadong Huang; Grit Laue; Jason Lee; Jamie Y Louie; Eliezer Masliah; Saliha Moussaoui; Joseph M Muchowski; Francesca M Notarangelo; Christina Patrick; Arash Rassoulpour; Korrapati V Sathyasaikumar; Kimberly Scearce-Levie; Robert Schwarcz; Jennifer Truong; Hui-Qiu Wu; Tiffany Wu; Paul J Muchowski
Kynurenine 3-monooxygenase inhibition in blood ameliorates neurodegeneration.
Cell 2011;145(6):863-74.
2011: Nga Bien-Ly; Yaisa Andrews-Zwilling; Qin Xu; Aubrey Bernardo; Charles Wang; Yadong Huang
C-terminal-truncated apolipoprotein (apo) E4 inefficiently clears amyloid-beta (Abeta) and acts in concert with Abeta to elicit neuronal and behavioral deficits in mice.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(10):4236-41.
2010: Yaisa Andrews-Zwilling; Nga Bien-Ly; Qin Xu; Gang Li; Aubrey Bernardo; Seo-Yeon Yoon; Daniel Zwilling; Tonya Xue Yan; Ligong Chen; Yadong Huang
Apolipoprotein E4 causes age- and Tau-dependent impairment of GABAergic interneurons, leading to learning and memory deficits in mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(41):13707-17.
2010: Yadong Huang
Mechanisms linking apolipoprotein E isoforms with cardiovascular and neurological diseases.
Current opinion in lipidology 2010;21(4):337-45.
2010: Yadong Huang
Abeta-independent roles of apolipoprotein E4 in the pathogenesis of Alzheimer's disease.
Trends in molecular medicine 2010;16(6):287-94.
2009: Gang Li; Nga Bien-Ly; Yaisa Andrews-Zwilling; Qin Xu; Aubrey Bernardo; Karen Ring; Brian Halabisky; Changhui Deng; Robert W Mahley; Yadong Huang
GABAergic interneuron dysfunction impairs hippocampal neurogenesis in adult apolipoprotein E4 knockin mice.
Cell stem cell 2009;5(6):634-45.
2009: Ina C. Tesseur; Hui Zhang; Walter Brecht; Jacob Corn; Jian-Sheng Gong; Katsuhiko Yanagisawa; Makoto Michikawa; Karl H Weisgraber; Yadong Huang; Tony Wyss-Coray
Bioactive TGF-beta can associate with lipoproteins and is enriched in those containing apolipoprotein E3.
Journal of neurochemistry 2009;110(4):1254-62.
2009: Robert W Mahley; Karl H Weisgraber; Yadong Huang
Apolipoprotein E: structure determines function, from atherosclerosis to Alzheimer's disease to AIDS.
Journal of lipid research 2009;50 Suppl():S183-8.
2008: Trevor D Burt; Brian Agan; Vincent Marconi; Weijing He; Hemant Kulkharni ; Jeffrey E Mold; Marielle Cavrois; Yadong Huang; Robert W Mahley; Matthew J Dolan; Joseph M McCune; Sunil Ahuja
Apolipoprotein (apo) E4 enhances HIV-1 cell entry in vitro, and the APOE epsilon4/epsilon4 genotype accelerates HIV disease progression.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(25):8718-23.
2008: Qin Xu; David Walker; Aubrey Bernardo; Jens Brodbeck; Maureen E Balestra; Yadong Huang
Intron-3 retention/splicing controls neuronal expression of apolipoprotein E in the CNS.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(6):1452-9.
2008: Jens Brodbeck; Maureen E Balestra; Ann M Saunders; Allen D Roses; Robert W Mahley; Yadong Huang
Rosiglitazone increases dendritic spine density and rescues spine loss caused by apolipoprotein E4 in primary cortical neurons.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(4):1343-6.
2006: Yadong Huang
Molecular and cellular mechanisms of apolipoprotein E4 neurotoxicity and potential therapeutic strategies.
Current opinion in drug discovery & development 2006;9(5):627-41.
2006: Qin Xu; Aubrey Bernardo; David Walker; Tiffany Kanegawa; Robert W Mahley; Yadong Huang
Profile and regulation of apolipoprotein E (ApoE) expression in the CNS in mice with targeting of green fluorescent protein gene to the ApoE locus.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(19):4985-94.
2006: Robert W Mahley; Karl H Weisgraber; Yadong Huang
Apolipoprotein E4: a causative factor and therapeutic target in neuropathology, including Alzheimer's disease.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(15):5644-51.
2006: Yadong Huang; Robert W Mahley
Commentary on "Perspective on a pathogenesis and treatment of Alzheimer's disease." Apolipoprotein E and the mitochondrial metabolic hypothesis.
Alzheimer's & dementia : the journal of the Alzheimer's Association 2006;2(2):71-3.
2006: Zhong-Sheng Ji; Karin Müllendorff; Irene H Cheng; R Dennis Miranda; Yadong Huang; Robert W Mahley
Reactivity of apolipoprotein E4 and amyloid beta peptide: lysosomal stability and neurodegeneration.
The Journal of biological chemistry 2006;281(5):2683-92.
2006: Yadong Huang
Apolipoprotein E and Alzheimer disease.
Neurology 2006;66(2 Suppl 1):S79-85.
2006: Robert W Mahley; Yadong Huang
Apolipoprotein (apo) E4 and Alzheimer's disease: unique conformational and biophysical properties of apoE4 can modulate neuropathology.
Acta neurologica Scandinavica. Supplementum 2006;185():8-14.
2006: Ugur Hodoglugil; Sinan Tanyolaç; David W Williamson; Yadong Huang; Robert W Mahley
Apolipoprotein A-V: a potential modulator of plasma triglyceride levels in Turks.
Journal of lipid research 2006;47(1):144-53.
2005: Shengjun Chang; Tian ran Ma; R Dennis Miranda; Maureen E Balestra; Robert W Mahley; Yadong Huang
Lipid- and receptor-binding regions of apolipoprotein E4 fragments act in concert to cause mitochondrial dysfunction and neurotoxicity.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(51):18694-9.
2005: Shiming Ye; Yadong Huang; Karin Müllendorff; Liming Dong; Gretchen Giedt; Elaine C Meng; Fred Cohen; Irwin D Kuntz; Karl H Weisgraber; Robert W Mahley
Apolipoprotein (apo) E4 enhances amyloid beta peptide production in cultured neuronal cells: apoE structure as a potential therapeutic target.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(51):18700-5.
2005: Uğur Hodoğlugil; David W Williamson; Yadong Huang; Robert W Mahley
Common polymorphisms of ATP binding cassette transporter A1, including a functional promoter polymorphism, associated with plasma high density lipoprotein cholesterol levels in Turks.
Atherosclerosis 2005;183(2):199-212.
2005: Gayathri Ramaswamy; Qin Xu; Yadong Huang; Karl H Weisgraber
Effect of domain interaction on apolipoprotein E levels in mouse brain.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(46):10658-63.
2005: U Hodoğlugil; David W Williamson; Yadong Huang; Robert W Mahley
An interaction between the TaqIB polymorphism of cholesterol ester transfer protein and smoking is associated with changes in plasma high-density lipoprotein cholesterol levels in Turks.
Clinical genetics 2005;68(2):118-27.
2004: Faith M Harris; Walter J Brecht; Qin Xu; Robert W Mahley; Yadong Huang
Increased tau phosphorylation in apolipoprotein E4 transgenic mice is associated with activation of extracellular signal-regulated kinase: modulation by zinc.
The Journal of biological chemistry 2004;279(43):44795-801.
2004: Qin Xu; Walter J Brecht; Karl H Weisgraber; Robert W Mahley; Yadong Huang
Apolipoprotein E4 domain interaction occurs in living neuronal cells as determined by fluorescence resonance energy transfer.
The Journal of biological chemistry 2004;279(24):25511-6.
2004: Walter J Brecht; Faith M Harris; Shengjun Chang; Ina C. Tesseur; Gui-Qiu Yu; Qin Xu; Jo Dee Fish; Tony Wyss-Coray; Manuel Buttini; Lennart Mucke; Robert W Mahley; Yadong Huang
Neuron-specific apolipoprotein e4 proteolysis is associated with increased tau phosphorylation in brains of transgenic mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(10):2527-34.
2004: Faith M Harris; Ina C. Tesseur; Walter J Brecht; Qin Xu; Karin Mullendorff; Shengjun Chang; Tony Wyss-Coray; Robert W Mahley; Yadong Huang
Astroglial regulation of apolipoprotein E expression in neuronal cells. Implications for Alzheimer's disease.
The Journal of biological chemistry 2004;279(5):3862-8.
2004: Yadong Huang; Karl H Weisgraber; Lennart Mucke; Robert W Mahley
Apolipoprotein E: diversity of cellular origins, structural and biophysical properties, and effects in Alzheimer's disease.
Journal of molecular neuroscience : MN 2004;23(3):189-204.
2003: Faith M Harris; Walter J Brecht; Qin Xu; Ina C. Tesseur; Lisa Kekonius; Tony Wyss-Coray; Jo Dee Fish; Eliezer Masliah; Paul C Hopkins; Kimberly Scearce-Levie; Karl H Weisgraber; Lennart Mucke; Robert W Mahley; Yadong Huang
Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimer's disease-like neurodegeneration and behavioral deficits in transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(19):10966-71.
2002: Manuel Buttini; Gui-Qiu Yu; Kristina Shockley; Yadong Huang; Brian Jones; Eliezer Masliah; Margaret Mallory; Tracy Yeo; Frank M Longo; Lennart Mucke
Modulation of Alzheimer-like synaptic and cholinergic deficits in transgenic mice by human apolipoprotein E depends on isoform, aging, and overexpression of amyloid beta peptides but not on plaque formation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(24):10539-48.
2002: Paul C R Hopkins; Yadong Huang; James G McGuire; Robert E Pitas
Evidence for differential effects of apoE3 and apoE4 on HDL metabolism.
Journal of lipid research 2002;43(11):1881-9.
2002: Zhong-Sheng Ji; R Dennis Miranda; Yvonne Newhouse; Karl H Weisgraber; Yadong Huang; Robert W Mahley
Apolipoprotein E4 potentiates amyloid beta peptide-induced lysosomal leakage and apoptosis in neuronal cells.
The Journal of biological chemistry 2002;277(24):21821-8.
2001: Yadong Huang; X Q Liu; Tony Wyss-Coray; Walter J Brecht; David A Sanan; Robert W Mahley
Apolipoprotein E fragments present in Alzheimer's disease brains induce neurofibrillary tangle-like intracellular inclusions in neurons.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(15):8838-43.
1999: Yadong Huang; Zhong-Sheng Ji; Walter J Brecht; SC Rall; John M Taylor; Robert W Mahley
Overexpression of apolipoprotein E3 in transgenic rabbits causes combined hyperlipidemia by stimulating hepatic VLDL production and impairing VLDL lipolysis.
Arteriosclerosis, thrombosis, and vascular biology 1999;19(12):2952-9.
1999: Robert W Mahley; Yadong Huang; SC Rall
Pathogenesis of type III hyperlipoproteinemia (dysbetalipoproteinemia). Questions, quandaries, and paradoxes.
Journal of lipid research 1999;40(11):1933-49.
1998: Yadong Huang; X Q Liu; SC Rall; John M Taylor; A von Eckardstein; G Assmann; Robert W Mahley
Overexpression and accumulation of apolipoprotein E as a cause of hypertriglyceridemia.
The Journal of biological chemistry 1998;273(41):26388-93.
1998: Yadong Huang; X Q Liu; SC Rall; Robert W Mahley
Apolipoprotein E2 reduces the low density lipoprotein level in transgenic mice by impairing lipoprotein lipase-mediated lipolysis of triglyceride-rich lipoproteins.
The Journal of biological chemistry 1998;273(28):17483-90.
1998: J Fan; Zhong-Sheng Ji; Yadong Huang; H de Silva; David A Sanan; Robert W Mahley; Thomas L Innerarity; John M Taylor
Increased expression of apolipoprotein E in transgenic rabbits results in reduced levels of very low density lipoproteins and an accumulation of low density lipoproteins in plasma.
The Journal of clinical investigation 1998;101(10):2151-64.
1997: Yadong Huang; SC Rall; Robert W Mahley
Genetic factors precipitating type III hyperlipoproteinemia in hypolipidemic transgenic mice expressing human apolipoprotein E2.
Arteriosclerosis, thrombosis, and vascular biology 1997;17(11):2817-24.
1997: Yadong Huang; S W Schwendner; SC Rall; David A Sanan; Robert W Mahley
Apolipoprotein E2 transgenic rabbits. Modulation of the type III hyperlipoproteinemic phenotype by estrogen and occurrence of spontaneous atherosclerosis.
The Journal of biological chemistry 1997;272(36):22685-94.
1996: Yadong Huang; S W Schwendner; SC Rall; Robert W Mahley
Hypolipidemic and hyperlipidemic phenotypes in transgenic mice expressing human apolipoprotein E2.
The Journal of biological chemistry 1996;271(46):29146-51.