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Anthony Auerbach

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TOP 3
Anthony Auerbach
The energy and work of a ligand-gated ion channel.
Prasad Purohit; Anthony Auerbach
Loop C and the mechanism of acetylcholine receptor-channel gating.
Iva Bruhova; Timothy Gregg; Anthony Auerbach
Energy for wild-type acetylcholine receptor channel gating from different choline derivatives.

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All Publications

2013: Anthony Auerbach
The energy and work of a ligand-gated ion channel.
Journal of molecular biology 2013;425(9):1461-75.
2013: Prasad Purohit; Anthony Auerbach
Loop C and the mechanism of acetylcholine receptor-channel gating.
The Journal of general physiology 2013;141(4):467-78.
2013: Iva Bruhova; Timothy Gregg; Anthony Auerbach
Energy for wild-type acetylcholine receptor channel gating from different choline derivatives.
Biophysical journal 2013;104(3):565-74.
2013: Snehal Jadey; Prasad Purohit; Anthony Auerbach
Action of nicotine and analogs on acetylcholine receptors having mutations of transmitter-binding site residue αG153.
The Journal of general physiology 2013;141(1):95-104.
2012: Snehal Jadey; Anthony Auerbach
An integrated catch-and-hold mechanism activates nicotinic acetylcholine receptors.
The Journal of general physiology 2012;140(1):17-28.
2012: Prasad Purohit; Iva Bruhova; Anthony Auerbach
Sources of energy for gating by neurotransmitters in acetylcholine receptor channels.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(24):9384-9.
2012: Tapan K Nayak; Prasad Purohit; Anthony Auerbach
The intrinsic energy of the gating isomerization of a neuromuscular acetylcholine receptor channel.
The Journal of general physiology 2012;139(5):349-58.
2011: Snehal V Jadey; Prasad Purohit; Iva Bruhova; Timothy M Gregg; Anthony Auerbach
Design and control of acetylcholine receptor conformational change.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(11):4328-33.
2011: Prasad Purohit; Anthony Auerbach
Glycine hinges with opposing actions at the acetylcholine receptor-channel transmitter binding site.
Molecular pharmacology 2011;79(3):351-9.
2011: Shaweta Gupta; Anthony Auerbach
Mapping heat exchange in an allosteric protein.
Biophysical journal 2011;100(4):904-11.
2011: Shaweta Gupta; Anthony Auerbach
Temperature dependence of acetylcholine receptor channels activated by different agonists.
Biophysical journal 2011;100(4):895-903.
2010: David J Cadugan; Anthony Auerbach
Linking the acetylcholine receptor-channel agonist-binding sites with the gate.
Biophysical journal 2010;99(3):798-807.
2010: Archana Jha; Anthony Auerbach
Acetylcholine receptor channels activated by a single agonist molecule.
Biophysical journal 2010;98(9):1840-6.
2010: Prasad Purohit; Anthony Auerbach
Energetics of gating at the apo-acetylcholine receptor transmitter binding site.
The Journal of general physiology 2010;135(4):321-31.
2010: Anthony Auerbach
The gating isomerization of neuromuscular acetylcholine receptors.
The Journal of physiology 2010;588(Pt 4):573-86.
2009: Archana Jha; Prasad Purohit; Anthony Auerbach
Energy and structure of the M2 helix in acetylcholine receptor-channel gating.
Biophysical journal 2009;96(10):4075-84.
2009: Pallavi A Bafna; Archana Jha; Anthony Auerbach
Aromatic Residues {epsilon}Trp-55 and {delta}Trp-57 and the Activation of Acetylcholine Receptor Channels.
The Journal of biological chemistry 2009;284(13):8582-8.
2009: Prasad Purohit; Anthony Auerbach
Unliganded gating of acetylcholine receptor channels.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(1):115-20.
2007: Prasad Purohit; Anthony Auerbach
Acetylcholine receptor gating: movement in the alpha-subunit extracellular domain.
The Journal of general physiology 2007;130(6):569-79.
2007: Prasad Purohit; Anthony Auerbach
Acetylcholine receptor gating at extracellular transmembrane domain interface: the "pre-M1" linker.
The Journal of general physiology 2007;130(6):559-68.
2007: Archana Jha; David J Cadugan; Prasad Purohit; Anthony Auerbach
Acetylcholine receptor gating at extracellular transmembrane domain interface: the cys-loop and M2-M3 linker.
The Journal of general physiology 2007;130(6):547-58.
2007: Anthony Auerbach
How to turn the reaction coordinate into time.
The Journal of general physiology 2007;130(6):543-6.
2007: David J Cadugan; Anthony Auerbach
Conformational dynamics of the alphaM3 transmembrane helix during acetylcholine receptor channel gating.
Biophysical journal 2007;93(3):859-65.
2007: Prasad Purohit; Ananya Mitra; Anthony Auerbach
A stepwise mechanism for acetylcholine receptor channel gating.
Nature 2007;446(7138):930-3.
2006: Gareth M C Lema; Anthony Auerbach
Modes and models of GABA(A) receptor gating.
The Journal of physiology 2006;572(Pt 1):183-200.
2005: Yu Zhou; John E Pearson; Anthony Auerbach
Phi-value analysis of a linear, sequential reaction mechanism: theory and application to ion channel gating.
Biophysical journal 2005;89(6):3680-5.
2005: Ananya Mitra; Richard Tascione; Anthony Auerbach; Stuart Licht
Plasticity of acetylcholine receptor gating motions via rate-energy relationships.
Biophysical journal 2005;89(5):3071-8.
2005: Ananya Mitra; Gisela D Cymes; Anthony Auerbach
Dynamics of the acetylcholine receptor pore at the gating transition state.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(42):15069-74.
2005: Anthony Auerbach; Yu Zhou
Gating reaction mechanisms for NMDA receptor channels.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(35):7914-23.
2005: Anthony Auerbach
Gating of acetylcholine receptor channels: brownian motion across a broad transition state.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(5):1408-12.
2005: Sudha Chakrapani; Anthony Auerbach
A speed limit for conformational change of an allosteric membrane protein.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(1):87-92.
2004: Gabriela Popescu; Antoine Robert; James R Howe; Anthony Auerbach
Reaction mechanism determines NMDA receptor response to repetitive stimulation.
Nature 2004;430(7001):790-3.
2004: Sudha Chakrapani; Timothy D Bailey; Anthony Auerbach
Gating dynamics of the acetylcholine receptor extracellular domain.
The Journal of general physiology 2004;123(4):341-56.
2003: Sudha Chakrapani; Timothy D Bailey; Anthony Auerbach
The role of loop 5 in acetylcholine receptor channel gating.
The Journal of general physiology 2003;122(5):521-39.
2003: Anthony Auerbach
Life at the top: the transition state of AChR gating.
Science's STKE : signal transduction knowledge environment 2003;2003(188):re11.
2002: Sergio Elenes; Anthony Auerbach
Desensitization of diliganded mouse muscle nicotinic acetylcholine receptor channels.
The Journal of physiology 2002;541(Pt 2):367-83.
2002: Gisela D Cymes; Claudio Grosman; Anthony Auerbach
Structure of the transition state of gating in the acetylcholine receptor channel pore: a phi-value analysis.
Biochemistry 2002;41(17):5548-55.
2001: Claudio Grosman; Anthony Auerbach
The dissociation of acetylcholine from open nicotinic receptor channels.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(24):14102-7.
2001: Y Zhu; Anthony Auerbach
K(+) occupancy of the N-methyl-d-aspartate receptor channel probed by Mg(2+) block.
The Journal of general physiology 2001;117(3):287-98.
2001: Y Zhu; Anthony Auerbach
Na(+) occupancy and Mg(2+) block of the n-methyl-d-aspartate receptor channel.
The Journal of general physiology 2001;117(3):275-86.
2000: F Qin; Anthony Auerbach; Frederick Sachs
A direct optimization approach to hidden Markov modeling for single channel kinetics.
Biophysical journal 2000;79(4):1915-27.
2000: Claudio Grosman; F N Salamone; S M Sine; Anthony Auerbach
The extracellular linker of muscle acetylcholine receptor channels is a gating control element.
The Journal of general physiology 2000;116(3):327-40.
2000: Claudio Grosman; Anthony Auerbach
Asymmetric and independent contribution of the second transmembrane segment 12' residues to diliganded gating of acetylcholine receptor channels: a single-channel study with choline as the agonist.
The Journal of general physiology 2000;115(5):637-51.
2000: Claudio Grosman; Anthony Auerbach
Kinetic, mechanistic, and structural aspects of unliganded gating of acetylcholine receptor channels: a single-channel study of second transmembrane segment 12' mutants.
The Journal of general physiology 2000;115(5):621-35.
2000: Claudio Grosman; M Zhou; Anthony Auerbach
Mapping the conformational wave of acetylcholine receptor channel gating.
Nature 2000;403(6771):773-6.
1999: Gustav Akk; Anthony Auerbach
Activation of muscle nicotinic acetylcholine receptor channels by nicotinic and muscarinic agonists.
British journal of pharmacology 1999;128(7):1467-76.
1999: M Zhou; A G Engel; Anthony Auerbach
Serum choline activates mutant acetylcholine receptors that cause slow channel congenital myasthenic syndromes.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(18):10466-71.
1999: F N Salamone; M Zhou; Anthony Auerbach
A re-examination of adult mouse nicotinic acetylcholine receptor channel activation kinetics.
The Journal of physiology 1999;516 ( Pt 2)():315-30.
1999: Gustav Akk; M Zhou; Anthony Auerbach
A mutational analysis of the acetylcholine receptor channel transmitter binding site.
Biophysical journal 1999;76(1 Pt 1):207-18.
1998: Anthony Auerbach; Gustav Akk
Desensitization of mouse nicotinic acetylcholine receptor channels. A two-gate mechanism.
The Journal of general physiology 1998;112(2):181-97.
1998: J Chen; Anthony Auerbach
A distinct contribution of the delta subunit to acetylcholine receptor channel activation revealed by mutations of the M2 segment.
Biophysical journal 1998;75(1):218-25.
1997: L S Premkumar; Anthony Auerbach
Stoichiometry of recombinant N-methyl-D-aspartate receptor channels inferred from single-channel current patterns.
The Journal of general physiology 1997;110(5):485-502.
1997: F Qin; Anthony Auerbach; Frederick Sachs
Maximum likelihood estimation of aggregated Markov processes.
Proceedings. Biological sciences / The Royal Society 1997;264(1380):375-83.
1997: L S Premkumar; F Qin; Anthony Auerbach
Subconductance states of a mutant NMDA receptor channel kinetics, calcium, and voltage dependence.
The Journal of general physiology 1997;109(2):181-9.
1996: Gustav Akk; Steven M Sine; Anthony Auerbach
Binding sites contribute unequally to the gating of mouse nicotinic alpha D200N acetylcholine receptors.
The Journal of physiology 1996;496 ( Pt 1)():185-96.
1996: Anthony Auerbach; WJ Sigurdson; J Chen; Gustav Akk
Voltage dependence of mouse acetylcholine receptor gating: different charge movements in di-, mono- and unliganded receptors.
The Journal of physiology 1996;494 ( Pt 1)():155-70.
1996: Gustav Akk; Anthony Auerbach
Inorganic, monovalent cations compete with agonists for the transmitter binding site of nicotinic acetylcholine receptors.
Biophysical journal 1996;70(6):2652-8.
1996: L S Premkumar; Anthony Auerbach
Identification of a high affinity divalent cation binding site near the entrance of the NMDA receptor channel.
Neuron 1996;16(4):869-80.
1996: F Qin; Anthony Auerbach; Frederick Sachs
Estimating single-channel kinetic parameters from idealized patch-clamp data containing missed events.
Biophysical journal 1996;70(1):264-80.
1995: J Chen; Y Zhang; Gustav Akk; Steven M Sine; Anthony Auerbach
Activation kinetics of recombinant mouse nicotinic acetylcholine receptors: mutations of alpha-subunit tyrosine 190 affect both binding and gating.
Biophysical journal 1995;69(3):849-59.
1995: Y Zhang; J Chen; Anthony Auerbach
Activation of recombinant mouse acetylcholine receptors by acetylcholine, carbamylcholine and tetramethylammonium.
The Journal of physiology 1995;486 ( Pt 1)():189-206.
1993: Anthony Auerbach
A statistical analysis of acetylcholine receptor activation in Xenopus myocytes: stepwise versus concerted models of gating.
The Journal of physiology 1993;461():339-78.
1992: Anthony Auerbach
Kinetic behavior of cloned mouse acetylcholine receptors. A semi-autonomous, stepwise model of gating.
Biophysical journal 1992;62(1):72-3.
1987: Anthony Auerbach; C J Lingle
Activation of the primary kinetic modes of large- and small-conductance cholinergic ion channels in Xenopus myocytes.
The Journal of physiology 1987;393():437-66.
1986: Anthony Auerbach; C J Lingle
Heterogeneous kinetic properties of acetylcholine receptor channels in Xenopus myocytes.
The Journal of physiology 1986;378():119-40.
1984: Anthony Auerbach; F Sachs
Patch clamp studies of single ionic channels.
Annual review of biophysics and bioengineering 1984;13():269-302.
1984: Anthony Auerbach; F Sachs
Single-channel currents from acetylcholine receptors in embryonic chick muscle. Kinetic and conductance properties of gaps within bursts.
Biophysical journal 1984;45(1):187-98.
1983: Anthony Auerbach; F Sachs
Flickering of a nicotinic ion channel to a subconductance state.
Biophysical journal 1983;42(1):1-10.