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John Hubbard

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TOP 3
Kamal K Midha; Maureen J Rawson; John W Hubbard
The bioequivalence of highly variable drugs and drug products.
Kamal K Midha; Maureen J Rawson; Gordon McKay; John W Hubbard
Exposure measures applied to the bioequivalence of two sustained release formulations of bupropion.
Kamal K Midha; Maureen J Rawson; John W Hubbard
The role of metabolites in bioequivalence.

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All Publications

2005: Kamal K Midha; Maureen J Rawson; John W Hubbard
The bioequivalence of highly variable drugs and drug products.
International journal of clinical pharmacology and therapeutics 2005;43(10):485-98.
2005: Kamal K Midha; Maureen J Rawson; Gordon McKay; John W Hubbard
Exposure measures applied to the bioequivalence of two sustained release formulations of bupropion.
International journal of clinical pharmacology and therapeutics 2005;43(5):244-54.
2004: Kamal K Midha; Maureen J Rawson; John W Hubbard
The role of metabolites in bioequivalence.
Pharmaceutical research 2004;21(8):1331-44.
2003: Karen E Mosier; Jiuxue Song; Gordon McKay; John W Hubbard; Jim Fang
Determination of clozapine, and its metabolites, N-desmethylclozapine and clozapine N-oxide in dog plasma using high-performance liquid chromatography.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2003;783(2):377-82.
2002: J-H Yan; John W Hubbard; Gordon McKay; E D Korchinski; Kamal K Midha
Absolute bioavailability and stereoselective pharmacokinetics of doxepin.
Xenobiotica; the fate of foreign compounds in biological systems 2002;32(7):615-23.
2001: Kamal K Midha; Gordon McKay; Maureen J Rawson; E D Korchinski; John W Hubbard
Effects of food on the pharmacokinetics of methylphenidate.
Pharmaceutical research 2001;18(8):1185-9.
2001: László Tóthfalusi; Laszlo Endrenyi; Kamal K Midha; Maureen J Rawson; John W Hubbard
Evaluation of the bioequivalence of highly-variable drugs and drug products.
Pharmaceutical research 2001;18(6):728-33.
2000: J Fang; Gordon McKay; John W Hubbard; Edward M Hawes; Kamal K Midha
Dose staggering as a strategy to reduce drug--drug interactions due to reversible enzyme inhibition between orally administered drugs with high first pass effect: a computer simulation study.
Biopharmaceutics & drug disposition 2000;21(7):249-59.
1999: Kamal K Midha; Maureen J Rawson; John W Hubbard
Prescribability and switchability of highly variable drugs and drug products.
Journal of controlled release : official journal of the Controlled Release Society 1999;62(1-2):33-40.
1999: Kamal K Midha; John W Hubbard; Gordon McKay; Maureen J Rawson; D Hsia
The role of metabolites in a bioequivalence study II: amoxapine, 7-hydroxyamoxapine, and 8-hydroxyamoxapine.
International journal of clinical pharmacology and therapeutics 1999;37(9):428-38.
1999: John W Hubbard; S Hadad; JP Luo; Gordon McKay; Kamal K Midha
Pharmacokinetics of fluphenazine, a highly lipophilic drug, estimated from a pulse dose of a stable isotopomer in dogs at steady state.
Journal of pharmaceutical sciences 1999;88(9):918-21.
1998: JP Luo; John W Hubbard; Kamal K Midha
The roles of depot injection sites and proximal lymph nodes in the presystemic absorption of fluphenazine decanoate and fluphenazine: ex vivo experiments in rats.
Pharmaceutical research 1998;15(9):1485-9.
1998: Kamal K Midha; Gordon McKay; Maureen J Rawson; John W Hubbard
The impact of stereoisomerism in bioequivalence studies.
Journal of pharmaceutical sciences 1998;87(7):797-802.
1998: Kamal K Midha; Maureen J Rawson; John W Hubbard
Bioequivalence: switchability and scaling.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 1998;6(2):87-91.
1997: Kamal K Midha; Maureen J Rawson; John W Hubbard
Bioequivalence: issues and options.
Journal of pharmacokinetics and biopharmaceutics 1997;25(6):743-52.
1997: J H Yan; John W Hubbard; Gordon McKay; Kamal K Midha
Stereoselective in vivo and in vitro studies on the metabolism of doxepin and N-desmethyldoxepin.
Xenobiotica; the fate of foreign compounds in biological systems 1997;27(12):1245-57.
1997: Kamal K Midha; Maureen J Rawson; John W Hubbard
Individual and average bioequivalence of highly variable drugs and drug products.
Journal of pharmaceutical sciences 1997;86(11):1193-7.
1997: JP Luo; John W Hubbard; Kamal K Midha
Studies on the mechanism of absorption of depot neuroleptics: fluphenazine decanoate in sesame oil.
Pharmaceutical research 1997;14(8):1079-84.
1997: J Yan; John W Hubbard; Gordon McKay; Kamal K Midha
Stereoselective and simultaneous measurement of cis- and trans-isomers of doxepin and N-desmethyldoxepin in plasma or urine by high-performance liquid chromatography.
Journal of chromatography. B, Biomedical sciences and applications 1997;691(1):131-8.
1997: JP Luo; John W Hubbard; Kamal K Midha
Sensitive method for the simultaneous measurement of fluphenazine decanoate and fluphenazine in plasma by high-performance liquid chromatography with coulometric detection.
Journal of chromatography. B, Biomedical sciences and applications 1997;688(2):303-8.
1996: G O Zhang; Gordon McKay; John W Hubbard; Kamal K Midha
Application of electrospray mass spectrometry in the identification of intact glucuronide and suplate conjugates of clozapine in rat.
Xenobiotica; the fate of foreign compounds in biological systems 1996;26(5):541-50.
1995: S Hadad; John W Hubbard; Gordon McKay; Edward M Hawes; S Shrikhande; Kamal K Midha
Evidence for the lack of a human metabolic isotope effect of a deuterium analog of fluphenazine.
Pharmaceutical research 1995;12(9):1388-90.
1994: Kamal K Midha; John W Hubbard; Stephen R Marder; BD Marshall; T Van Putten
Impact of clinical pharmacokinetics on neuroleptic therapy in patients with schizophrenia.
Journal of psychiatry & neuroscience : JPN 1994;19(4):254-64.
1993: John W Hubbard; Kamal K Midha; Edward M Hawes; Gordon McKay; Stephen R Marder; Manickam Aravagiri; E D Korchinski
Metabolism of phenothiazine and butyrophenone antipsychotic drugs. A review of some recent research findings and clinical implications.
The British journal of psychiatry. Supplement 1993;(22):19-24.
1993: Kamal K Midha; Stephen R Marder; T J Jaworski; Gordon McKay; John W Hubbard; Edward M Hawes; T Van Putten; William C Wirshing; Manickam Aravagiri
Clinical perspectives of some neuroleptics through development and application of their assays.
Therapeutic drug monitoring 1993;15(3):179-89.
1993: Kamal K Midha; John W Hubbard; Gordon McKay; Edward M Hawes; D Hsia
The role of metabolites in a bioequivalence study 1: loxapine, 7-hydroxyloxapine and 8-hydroxyloxapine.
International journal of clinical pharmacology, therapy, and toxicology 1993;31(4):177-83.
1993: T J Jaworski; M S Sardessai; Manickam Aravagiri; G Lin; Y Y Shi; Edward M Hawes; John W Hubbard; Gordon McKay; Kamal K Midha
Synthesis of the N-oxides of phenothiazine antipsychotic agents.
Journal of pharmaceutical sciences 1993;82(3):330-3.
1993: Kamal K Midha; E D Ormsby; John W Hubbard; Gordon McKay; Edward M Hawes; L Gavalas; I J McGilveray
Logarithmic transformation in bioequivalence: application with two formulations of perphenazine.
Journal of pharmaceutical sciences 1993;82(2):138-44.
1993: N R Srinivas; John W Hubbard; E D Korchinski; Kamal K Midha
Enantioselective pharmacokinetics of dl-threo-methylphenidate in humans.
Pharmaceutical research 1993;10(1):14-21.
1993: Pollen K F Yeung; John W Hubbard; E D Korchinski; Kamal K Midha
Pharmacokinetics of chlorpromazine and key metabolites.
European journal of clinical pharmacology 1993;45(6):563-9.
1992: N R Srinivas; John W Hubbard; D Quinn; Kamal K Midha
Enantioselective pharmacokinetics and pharmacodynamics of dl-threo-methylphenidate in children with attention deficit hyperactivity disorder.
Clinical pharmacology and therapeutics 1992;52(5):561-8.
1992: N R Srinivas; John W Hubbard; E D Korchinski; Kamal K Midha
Stereoselective urinary pharmacokinetics of dl-threo-methylphenidate and its major metabolite in humans.
Journal of pharmaceutical sciences 1992;81(8):747-9.
1992: Kamal K Midha; John W Hubbard; Gordon McKay; Edward M Hawes; E D Korchinski; T Gurnsey; J K Cooper; R Schwede
Stereoselective pharmacokinetics of doxepin isomers.
European journal of clinical pharmacology 1992;42(5):539-44.
1991: T J Jaworski; Edward M Hawes; John W Hubbard; Gordon McKay; Kamal K Midha
The metabolites of chlorpromazine N-oxide in rat bile.
Xenobiotica; the fate of foreign compounds in biological systems 1991;21(11):1451-9.
1991: C J Jackson; John W Hubbard; Kamal K Midha
Biosynthesis and characterization of glucuronide metabolites of fluphenazine: 7-hydroxyfluphenazine glucuronide and fluphenazine glucuronide.
Xenobiotica; the fate of foreign compounds in biological systems 1991;21(3):383-93.
1991: N R Srinivas; John W Hubbard; D Quinn; E D Korchinski; Kamal K Midha
Extensive and enantioselective presystemic metabolism of dl-threo-methylphenidate in humans.
Progress in neuro-psychopharmacology & biological psychiatry 1991;15(2):213-20.
1991: N R Srinivas; John W Hubbard; Gordon McKay; Edward M Hawes; Kamal K Midha
In vitro hydrolysis of RR,SS-threo-methylphenidate by blood esterases--differential and enantioselective interspecies variability.
Chirality 1991;3(2):99-103.
1991: C J Jackson; John W Hubbard; Gordon McKay; J K Cooper; Edward M Hawes; Kamal K Midha
Identification of phase-I and phase-II metabolites of fluphenazine in rat bile. Intact glucuronide and sulfate conjugates.
Drug metabolism and disposition: the biological fate of chemicals 1991;19(1):188-93.
1991: Y Z Shu; John W Hubbard; Gordon McKay; Edward M Hawes; Kamal K Midha
Cis-flupentixol metabolites in rat plasma and bile. The first proof of glutathione conjugation at the exocyclic double bond.
Drug metabolism and disposition: the biological fate of chemicals 1991;19(1):154-62.
1990: Y Z Shu; John W Hubbard; Gordon McKay; Kamal K Midha
Identification of phenolic doxepin glucuronides from patient urine and rat bile.
Drug metabolism and disposition: the biological fate of chemicals 1990;18(6):1096-9.
1990: N R Srinivas; John W Hubbard; Kamal K Midha
Enantioselective gas chromatographic assay with electron-capture detection for dl-ritalinic acid in plasma.
Journal of chromatography 1990;530(2):327-36.
1990: Y Z Shu; John W Hubbard; J K Cooper; Gordon McKay; E D Korchinski; R Kumar; Kamal K Midha
The identification of urinary metabolites of doxepin in patients.
Drug metabolism and disposition: the biological fate of chemicals 1990;18(5):735-41.
1990: Kamal K Midha; Gordon McKay; B S Chakraborty; M Young; Edward M Hawes; John W Hubbard; J K Cooper; E D Korchinski
Bioequivalence of two thorazine tablet formulations using radioimmunoassay and gas chromatographic-mass spectrometric methods.
Journal of pharmaceutical sciences 1990;79(3):196-201.
1990: Kamal K Midha; B S Chakraborty; R Schwede; Edward M Hawes; Gordon McKay; John W Hubbard; J K Cooper; M Moore
Comparative bioavailability of two tablet formulations of fluphenazine dihydrochloride in drug-free psychiatric patients.
Journal of pharmaceutical sciences 1990;79(1):3-8.
1989: John W Hubbard; N R Srinivas; D Quinn; Kamal K Midha
Enantioselective aspects of the disposition of dl-threo-methylphenidate after the administration of a sustained-release formulation to children with attention deficit-hyperactivity disorder.
Journal of pharmaceutical sciences 1989;78(11):944-7.
1989: B S Chakraborty; Kamal K Midha; Gordon McKay; Edward M Hawes; John W Hubbard; E D Korchinski; MG Choc; W T Robinson
Single dose kinetics of thioridazine and its two psychoactive metabolites in healthy humans: a dose proportionality study.
Journal of pharmaceutical sciences 1989;78(10):796-801.
1989: Kamal K Midha; B S Chakraborty; R Schwede; Edward M Hawes; John W Hubbard; Gordon McKay
Comparative bioavailability of a new commercial tablet formulation and two lots of a reference formulation of haloperidol.
Journal of pharmaceutical sciences 1989;78(6):443-7.
1989: Kamal K Midha; B S Chakraborty; D A Ganes; Edward M Hawes; John W Hubbard; David Keegan; E D Korchinski; Gordon McKay
Intersubject variation in the pharmacokinetics of haloperidol and reduced haloperidol.
Journal of clinical psychopharmacology 1989;9(2):98-104.
1989: BD Marshall; S M Glynn; Kamal K Midha; John W Hubbard; L L Bowen; L Banzett; Jim Mintz; Robert Paul Liberman
Adverse effects of fenfluramine in treatment refractory schizophrenia.
Journal of clinical psychopharmacology 1989;9(2):110-5.
1989: Kamal K Midha; Edward M Hawes; John W Hubbard; E D Korchinski; Gordon McKay
Intersubject variation in the pharmacokinetics of chlorpromazine in healthy men.
Journal of clinical psychopharmacology 1989;9(1):4-8.
1989: N R Srinivas; John W Hubbard; Edward M Hawes; Gordon McKay; Kamal K Midha
Enantioselective gas chromatographic assays with electron-capture detection for methoxyphenamine and its three primary metabolites in human urine.
Journal of chromatography 1989;487(1):61-72.
1989: J K Cooper; Edward M Hawes; John W Hubbard; Gordon McKay; Kamal K Midha
An ultrasensitive method for the measurement of fluphenazine in plasma by high-performance liquid chromatography with coulometric detection.
Therapeutic drug monitoring 1989;11(3):354-60.
1989: B S Chakraborty; John W Hubbard; Edward M Hawes; Gordon McKay; J K Cooper; T Gurnsey; E D Korchinski; Kamal K Midha
Interconversion between haloperidol and reduced haloperidol in healthy volunteers.
European journal of clinical pharmacology 1989;37(1):45-8.
1988: N R Srinivas; John W Hubbard; J K Cooper; Kamal K Midha
Enantioselective gas chromatographic assay with electron-capture detection for dl-fenfluramine and dl-norfenfluramine in plasma.
Journal of chromatography 1988;433():105-17.
1988: A K Chaudhary; John W Hubbard; Gordon McKay; Kamal K Midha
Identification of a quaternary ammonium-linked glucuronide of chlorpromazine in the urine of a schizophrenic patient treated with chlorpromazine.
Drug metabolism and disposition: the biological fate of chemicals 1988;16(3):506-8.
1988: Kamal K Midha; Edward M Hawes; John W Hubbard; Gordon McKay; G Rauw; M S Sardessai; Manickam Aravagiri; M D Moore
Radioimmunoassay for fluphenazine sulfoxide in human plasma.
Journal of pharmacological methods 1988;19(1):63-74.
1988: M B Gupta; John W Hubbard; Kamal K Midha
Separation of enantiomers of derivatised or underivatised propranolol by means of high-performance liquid chromatography.
Journal of chromatography 1988;424(1):189-94.
1988: Kamal K Midha; J K Cooper; Edward M Hawes; John W Hubbard; E D Korchinski; Gordon McKay
An ultrasensitive method for the measurement of haloperidol and reduced haloperidol in plasma by high-performance liquid chromatography with coulometric detection.
Therapeutic drug monitoring 1988;10(2):177-83.
1988: B S Chakraborty; Edward M Hawes; Gordon McKay; John W Hubbard; E D Korchinski; Kamal K Midha; MG Choc; W T Robinson
S-oxidation of thioridazine to psychoactive metabolites: an oral dose-proportionality study in healthy volunteers.
Drug metabolism and drug interactions 1988;6(3-4):425-37.
1988: Kamal K Midha; Edward M Hawes; John W Hubbard; E D Korchinski; Gordon McKay
Variation in the single dose pharmacokinetics of fluphenazine in psychiatric patients.
Psychopharmacology 1988;96(2):206-11.
1988: Kamal K Midha; Edward M Hawes; John W Hubbard; E D Korchinski; Gordon McKay
A pharmacokinetic study of trifluoperazine in two ethnic populations.
Psychopharmacology 1988;95(3):333-8.
1987: Kamal K Midha; John W Hubbard; J K Cooper; T Gurnsey; Edward M Hawes; Gordon McKay; B S Chakraborty; Pollen K F Yeung
Therapeutic monitoring of chlorpromazine. IV: Comparison of a new high-performance liquid chromatographic method with radioimmunoassays for parent drug and some of its major metabolites.
Therapeutic drug monitoring 1987;9(3):358-65.
1987: N R Srinivas; D Quinn; John W Hubbard; Kamal K Midha
Stereoselective disposition of methylphenidate in children with attention-deficit disorder.
The Journal of pharmacology and experimental therapeutics 1987;241(1):300-6.
1987: Kamal K Midha; John W Hubbard; Stephen R Marder; Edward M Hawes; T Van Putten; Gordon McKay; P R May
The sulfoxidation of fluphenazine in schizophrenic patients maintained on fluphenazine decanoate.
Psychopharmacology 1987;93(3):369-73.
1986: Stephen R Marder; John W Hubbard; T Van Putten; Edward M Hawes; Gordon McKay; Jim Mintz; P R May; Kamal K Midha
Plasma fluphenazine levels in patients receiving two doses of fluphenazine decanoate.
Psychopharmacology bulletin 1986;22(1):264-6.
1986: Stephen R Marder; Edward M Hawes; T Van Putten; John W Hubbard; Gordon McKay; Jim Mintz; P R May; Kamal K Midha
Fluphenazine plasma levels in patients receiving low and conventional doses of fluphenazine decanoate.
Psychopharmacology 1986;88(4):480-3.
1985: John W Hubbard; J K Cooper; Edward M Hawes; D J Jenden; P R May; M Martin; Gordon McKay; T Van Putten; Kamal K Midha
Therapeutic monitoring of chlorpromazine I: Pitfalls in plasma analysis.
Therapeutic drug monitoring 1985;7(2):222-8.
1983: Kamal K Midha; Edward M Hawes; Gordon McKay; John W Hubbard; E D Korchinski; David Keegan
Plasma concentrations of trifluoperazine following single low doses.
Canadian Medical Association journal 1983;129(4):324.
1981: Kamal K Midha; J K Cooper; I J McGilveray; A G Butterfield; John W Hubbard
High-performance liquid chromatographic assay for nanogram determination of chlorpromazine and its comparison with a radioimmunoassay.
Journal of pharmaceutical sciences 1981;70(9):1043-6.