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Robert Huber

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Concepts & Ideas

Procedures

Genes & Molecular Sequences

Amino Acid Sequence

Chemicals & Drugs

Phenomena

Living Beings

Escherichia coli

Physiology

Protein Folding

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Co-Publications
Name
104
Bode, Wolfram
43
Bacher, Adelbert
39
Messerschmidt, Albrecht
35
Engh, Richard
30
Groll, Michael
29
Fischer, Markus
29
Steinbacher, Stefan
28
Moroder, Luis
27
Clausen, Tim
22
Nar, Herbert
20
Brandstetter, Hans
19
Bartunik, Hans
18
Jacob, Uwe
18
Maskos, Klaus
17
Laber, Bernd

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Publications

TOP 3
Meltzer Michael; Hasenbein Sonja; Mamant Nicolette; Merdanovic Melisa; Poepsel Simon; Hauske Patrick; Kaiser Markus; Huber Robert; Krojer Tobias; Clausen Tim; Ehrmann Michael
Structure, function and regulation of the conserved serine proteases DegP and DegS of Escherichia coli.
Breithaupt Constanze; Kurzbauer Robert; Schaller Florian; Stintzi Annick; Schaller Andreas; Huber Robert; Macheroux Peter; Clausen Tim
Structural basis of substrate specificity of plant 12-oxophytodienoate reductases.
Lee Jung-Hoon; Maskos Klaus; Huber Robert
Structural and functional studies of the yeast class II Hda1 histone deacetylase complex.

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All Publications

2009: Meltzer Michael; Hasenbein Sonja; Mamant Nicolette; Merdanovic Melisa; Poepsel Simon; Hauske Patrick; Kaiser Markus; Huber Robert; Krojer Tobias; Clausen Tim; Ehrmann Michael
Structure, function and regulation of the conserved serine proteases DegP and DegS of Escherichia coli.
Research in microbiology 2009;160(9):660-6.
2009: Breithaupt Constanze; Kurzbauer Robert; Schaller Florian; Stintzi Annick; Schaller Andreas; Huber Robert; Macheroux Peter; Clausen Tim
Structural basis of substrate specificity of plant 12-oxophytodienoate reductases.
Journal of molecular biology 2009;392(5):1266-77.
2009: Lee Jung-Hoon; Maskos Klaus; Huber Robert
Structural and functional studies of the yeast class II Hda1 histone deacetylase complex.
Journal of molecular biology 2009;391(4):744-57.
2009: Huber Robert; Scheidle Marco; Dittrich Barbara; Klee Doris; Büchs Jochen
Equalizing growth in high-throughput small scale cultivations via precultures operated in fed-batch mode.
Biotechnology and bioengineering 2009;103(6):1095-102.
2009: Wolschner Christina; Giese Armin; Kretzschmar Hans A; Huber Robert; Moroder Luis; Budisa Nediljko
Design of anti- and pro-aggregation variants to assess the effects of methionine oxidation in human prion protein.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(19):7756-61.
2009: Sanglas Laura; Aviles Francesc X; Huber Robert; Gomis-Rüth F Xavier; Arolas Joan L
Mammalian metallopeptidase inhibition at the defense barrier of Ascaris parasite.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(6):1743-7.
2009: Groll Michael; Huber Robert; Moroder Luis
The persisting challenge of selective and specific proteasome inhibition.
Journal of peptide science : an official publication of the European Peptide Society 2009;15(2):58-66.
2009: Huber Robert; Ritter Daniel; Hering Till; Hillmer Anne-Kathrin; Kensy Frank; Müller Carsten; Wang Le; Büchs Jochen
Robo-Lector - a novel platform for automated high-throughput cultivations in microtiter plates with high information content.
Microbial cell factories 2009;8():42.
2008: Bergner A; Huber R M
Regulation of the endoplasmic reticulum Ca(2+)-store in cancer.
Anti-cancer agents in medicinal chemistry 2008;8(7):705-9.
2008: Chatwell Lorenz; Illarionova Victoria; Illarionov Boris; Eisenreich Wolfgang; Huber Robert; Skerra Arne; Bacher Adelbert; Fischer Markus
Structure of lumazine protein, an optical transponder of luminescent bacteria.
Journal of molecular biology 2008;382(1):44-55.
2008: Borelli Claudia; Ruge Elisabeth; Lee Jung Hoon; Schaller Martin; Vogelsang Alexandra; Monod Michel; Korting Hans Christian; Huber Robert; Maskos Klaus
X-ray structures of Sap1 and Sap5: structural comparison of the secreted aspartic proteinases from Candida albicans.
Proteins 2008;72(4):1308-19.
2008: Breithaupt Constanze; Schäfer Beatrix; Pellkofer Hannah; Huber Robert; Linington Christopher; Jacob Uwe
Demyelinating myelin oligodendrocyte glycoprotein-specific autoantibody response is focused on one dominant conformational epitope region in rodents.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(2):1255-63.
2008: Eigenwillig Christoph M; Biedermann Benjamin R; Palte Gesa; Huber Robert
K-space linear Fourier domain mode locked laser and applications for optical coherence tomography.
Optics express 2008;16(12):8916-37.
2008: Krojer Tobias; Pangerl Karen; Kurt Juliane; Sawa Justyna; Stingl Christoph; Mechtler Karl; Huber Robert; Ehrmann Michael; Clausen Tim
Interplay of PDZ and protease domain of DegP ensures efficient elimination of misfolded proteins.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(22):7702-7.
2008: Gonçalves Luís G; Lamosa Pedro; Huber Robert; Santos Helena
Di-myo-inositol phosphate and novel UDP-sugars accumulate in the extreme hyperthermophile Pyrolobus fumarii.
Extremophiles : life under extreme conditions 2008;12(3):383-9.
2008: Groll Michael; Schellenberg Barbara; Bachmann André S; Archer Crystal R; Huber Robert; Powell Tracy K; Lindow Steven; Kaiser Markus; Dudler Robert
A plant pathogen virulence factor inhibits the eukaryotic proteasome by a novel mechanism.
Nature 2008;452(7188):755-8.
2007: Debela Mekdes; Goettig Peter; Magdolen Viktor; Huber Robert; Schechter Norman M; Bode Wolfram
Structural basis of the zinc inhibition of human tissue kallikrein 5.
Journal of molecular biology 2007;373(4):1017-31.
2007: Debela Mekdes; Hess Petra; Magdolen Viktor; Schechter Norman M; Steiner Thomas; Huber Robert; Bode Wolfram; Goettig Peter
Chymotryptic specificity determinants in the 1.0 A structure of the zinc-inhibited human tissue kallikrein 7.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(41):16086-91.
2007: Velarde Milko; Huber Robert; Yanagisawa Sachiko; Dennison Christopher; Messerschmidt Albrecht
Influence of loop shortening on the metal binding site of cupredoxin pseudoazurin.
Biochemistry 2007;46(35):9981-91.
2007: Tochowicz Anna; Maskos Klaus; Huber Robert; Oltenfreiter Ruth; Dive Vincent; Yiotakis Athanasios; Zanda Matteo; Pourmotabbed Tayebeh; Bode Wolfram; Goettig Peter
Crystal structures of MMP-9 complexes with five inhibitors: contribution of the flexible Arg424 side-chain to selectivity.
Journal of molecular biology 2007;371(4):989-1006.
2007: Borelli Claudia; Ruge Elisabeth; Schaller Martin; Monod Michel; Korting Hans Christian; Huber Robert; Maskos Klaus
The crystal structure of the secreted aspartic proteinase 3 from Candida albicans and its complex with pepstatin A.
Proteins 2007;68(3):738-48.
2007: Kyrieleis Otto J P; Huber Robert; Ong Edgar; Oehler Ryan; Hunter Mike; Madison Edwin L; Jacob Uwe
Crystal structure of the catalytic domain of DESC1, a new member of the type II transmembrane serine proteinase family.
The FEBS journal 2007;274(8):2148-60.
2007: Steiner Thomas; Lamerz Anne-Christin; Hess Petra; Breithaupt Constanze; Krapp Stephan; Bourenkov Gleb; Huber Robert; Gerardy-Schahn Rita; Jacob Uwe
Open and closed structures of the UDP-glucose pyrophosphorylase from Leishmania major.
The Journal of biological chemistry 2007;282(17):13003-10.
2007: Kotsianos-Hermle Dorothea; Scherr M; Wirth S; Rieger J; Huber R M; Reiser M; Hautmann H
Visualization of bronchial lesions using multidetector CT and endobronchial ultrasound (EBUS).
European journal of medical research 2007;12(2):84-9.
2007: Keil Cora; Maskos Klaus; Than Manuel; Hoopes J Todd; Huber Robert; Tan Fulong; Deddish Peter A; Erdös Ervin G; Skidgel Randal A; Bode Wolfram
Crystal structure of the human carboxypeptidase N (kininase I) catalytic domain.
Journal of molecular biology 2007;366(2):504-16.
2006: Bergner A; Kellner J; Gamarra F; Huber R M
[Ca2+-signaling in smooth muscles cells of the airways in T-bet knock-out mice]
Pneumologie (Stuttgart, Germany) 2006;60(11):711-5.
2006: Debela Mekdes; Magdolen Viktor; Grimminger Valerie; Sommerhoff Christian; Messerschmidt Albrecht; Huber Robert; Friedrich Rainer; Bode Wolfram; Goettig Peter
Crystal structures of human tissue kallikrein 4: activity modulation by a specific zinc binding site.
Journal of molecular biology 2006;362(5):1094-107.
2006: Breithaupt Constanze; Kurzbauer Robert; Lilie Hauke; Schaller Andreas; Strassner Jochen; Huber Robert; Macheroux Peter; Clausen Tim
Crystal structure of 12-oxophytodienoate reductase 3 from tomato: self-inhibition by dimerization.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(39):14337-42.
2006: Tamulaitiene Giedre; Jakubauskas Arturas; Urbanke Claus; Huber Robert; Grazulis Saulius; Siksnys Virginijus
The crystal structure of the rare-cutting restriction enzyme SdaI reveals unexpected domain architecture.
Structure (London, England : 1993) 2006;14(9):1389-400.
2006: Sitar Tomasz; Popowicz Grzegorz M; Siwanowicz Igor; Huber Robert; Holak Tad A
Structural basis for the inhibition of insulin-like growth factors by insulin-like growth factor-binding proteins.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(35):13028-33.
2006: Chatwell Lorenz; Krojer Tobias; Fidler Alexander; Römisch Werner; Eisenreich Wolfgang; Bacher Adelbert; Huber Robert; Fischer Markus
Biosynthesis of riboflavin: structure and properties of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase of Methanocaldococcus jannaschii.
Journal of molecular biology 2006;359(5):1334-51.
2006: Huber R M; Reck M; Gosse H; von Pawel J; Mezger J; Saal J G; Kleinschmidt R; Steppert C; Steppling H
Efficacy of a toxicity-adjusted topotecan therapy in recurrent small cell lung cancer.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2006;27(6):1183-9.
2006: Groll Michael; Huber Robert; Potts Barbara C M
Crystal structures of Salinosporamide A (NPI-0052) and B (NPI-0047) in complex with the 20S proteasome reveal important consequences of beta-lactone ring opening and a mechanism for irreversible binding.
Journal of the American Chemical Society 2006;128(15):5136-41.
2006: Groll Michael; Larionov Oleg V; Huber Robert; de Meijere Armin
Inhibitor-binding mode of homobelactosin C to proteasomes: new insights into class I MHC ligand generation.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(12):4576-9.
2006: Rohr Kerstin B; Selwood Trevor; Marquardt Ulf; Huber Robert; Schechter Norman M; Bode Wolfram; Than Manuel E
X-ray structures of free and leupeptin-complexed human alphaI-tryptase mutants: indication for an alpha-->beta-tryptase transition.
Journal of molecular biology 2006;357(1):195-209.
2006: Bergner A; Kellner J; Kemp da Silva A; Fischer R; Gamarra F; Huber R M
Bronchial hyperreactivity is correlated with increased baseline airway tone.
European journal of medical research 2006;11(2):77-84.
2006: Engel Michael; Hoffmann Torsten; Manhart Susanne; Heiser Ulrich; Chambre Sylvie; Huber Robert; Demuth Hans-Ulrich; Bode Wolfram
Rigidity and flexibility of dipeptidyl peptidase IV: crystal structures of and docking experiments with DPIV.
Journal of molecular biology 2006;355(4):768-83.
2006: Ramsperger Arne; Augustin Martin; Schott Ann-Kathrin; Gerhardt Stefan; Krojer Tobias; Eisenreich Wolfgang; Illarionov Boris; Cushman Mark; Bacher Adelbert; Huber Robert; Fischer Markus
Crystal structure of an archaeal pentameric riboflavin synthase in complex with a substrate analog inhibitor: stereochemical implications.
The Journal of biological chemistry 2006;281(2):1224-32.
2005: Golbik Ralph; Yu Chao; Weyher-Stingl Elisabeth; Huber Robert; Moroder Luis; Budisa Nediljko; Schiene-Fischer Cordelia
Peptidyl prolyl cis/trans-isomerases: comparative reactivities of cyclophilins, FK506-binding proteins, and parvulins with fluorinated oligopeptide and protein substrates.
Biochemistry 2005;44(49):16026-34.
2005: Fischer R; Lang S M; Bergner A; Huber R M
Monitoring of expiratory flow rates and lung volumes during a high altitude expedition.
European journal of medical research 2005;10(11):469-74.
2005: Grazulis Saulius; Manakova Elena; Roessle Manfred; Bochtler Matthias; Tamulaitiene Giedre; Huber Robert; Siksnys Virginijus
Structure of the metal-independent restriction enzyme BfiI reveals fusion of a specific DNA-binding domain with a nonspecific nuclease.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(44):15797-802.
2005: Breitenlechner Christine B; Kairies Norman A; Honold Konrad; Scheiblich Stefan; Koll Hans; Greiter Eva; Koch Stefan; Schäfer Wolfgang; Huber Robert; Engh Richard A
Crystal structures of active SRC kinase domain complexes.
Journal of molecular biology 2005;353(2):222-31.
2005: Arolas Joan L; Popowicz Grzegorz M; Bronsoms Sílvia; Aviles Francesc X; Huber Robert; Holak Tad A; Ventura Salvador
Study of a major intermediate in the oxidative folding of leech carboxypeptidase inhibitor: contribution of the fourth disulfide bond.
Journal of molecular biology 2005;352(4):961-75.
2005: Goettig Peter; Brandstetter Hans; Groll Michael; Göhring Walter; Konarev Peter V; Svergun Dmitri I; Huber Robert; Kim Jeong-Sun
X-ray snapshots of peptide processing in mutants of tricorn-interacting factor F1 from Thermoplasma acidophilum.
The Journal of biological chemistry 2005;280(39):33387-96.
2005: Lang Susanne M; Ebelt K; Hautmann H; Stratakis D F; Huber R M
Detection of cancerous endobronchial lesions by autofluorescence bronchoscopy combined with mutation analysis of p53.
European journal of medical research 2005;10(7):273-7.
2005: Arolas Joan L; Popowicz Grzegorz M; Lorenzo Julia; Sommerhoff Christian P; Huber Robert; Aviles Francesc X; Holak Tad A
The three-dimensional structures of tick carboxypeptidase inhibitor in complex with A/B carboxypeptidases reveal a novel double-headed binding mode.
Journal of molecular biology 2005;350(3):489-98.
2005: Kyrieleis Otto J P; Goettig Peter; Kiefersauer Reiner; Huber Robert; Brandstetter Hans
Crystal structures of the tricorn interacting factor F3 from Thermoplasma acidophilum, a zinc aminopeptidase in three different conformations.
Journal of molecular biology 2005;349(4):787-800.
2005: Rostock M; Huber R; Greiner T; Fritz P; Scheer R; Schueler J; Fiebig H H
Anticancer activity of a lectin-rich mistletoe extract injected intratumorally into human pancreatic cancer xenografts.
Anticancer research 2005;25(3B):1969-75.
2005: Huber R M; Gamarra F
[It is still coming: molecular-targeted therapy of lung cancer]
Pneumologie (Stuttgart, Germany) 2005;59(5):309-10.
2005: Than Manuel E; Henrich Stefan; Bourenkov Gleb P; Bartunik Hans D; Huber Robert; Bode Wolfram
The endoproteinase furin contains two essential Ca2+ ions stabilizing its N-terminus and the unique S1 specificity pocket.
Acta crystallographica. Section D, Biological crystallography 2005;61(Pt 5):505-12.
2005: Fischer R; Lang S M; Brückner K; Hoyer H-X; Meyer S; Griese M; Huber R M
Lung function in adults with cystic fibrosis at altitude: impact on air travel.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2005;25(4):718-24.
2005: Wisniewska Magdalena; Bossenmaier Birgit; Georges Guy; Hesse Friederike; Dangl Markus; Künkele Klaus-Peter; Ioannidis Ioannis; Huber Robert; Engh Richard A
The 1.1 A resolution crystal structure of the p130cas SH3 domain and ramifications for ligand selectivity.
Journal of molecular biology 2005;347(5):1005-14.
2005: Jauch Ralf; Humm Andreas; Huber Robert; Wahl Markus C
Structures of Escherichia coli NAD synthetase with substrates and products reveal mechanistic rearrangements.
The Journal of biological chemistry 2005;280(15):15131-40.
2005: Einsle Oliver; Niessen Holger; Abt Dietmar J; Seiffert Grazyna; Schink Bernhard; Huber Robert; Messerschmidt Albrecht; Kroneck Peter M H
Crystallization and preliminary X-ray analysis of the tungsten-dependent acetylene hydratase from Pelobacter acetylenicus.
Acta crystallographica. Section F, Structural biology and crystallization communications 2005;61(Pt 3):299-301.
2005: Pal Prajna P; Bae Jae Hyun; Azim M Kamran; Hess Petra; Friedrich Rainer; Huber Robert; Moroder Luis; Budisa Nediljko
Structural and spectral response of Aequorea victoria green fluorescent proteins to chromophore fluorination.
Biochemistry 2005;44(10):3663-72.
2005: Huber R; Futter I; Lüdtke R
Oral silymarin for chronic hepatitis C - a retrospective analysis comparing three dose regimens.
European journal of medical research 2005;10(2):68-70.
2005: Groll Michael; Bochtler Matthias; Brandstetter Hans; Clausen Tim; Huber Robert
Molecular machines for protein degradation.
Chembiochem : a European journal of chemical biology 2005;6(2):222-56.
2005: Theodoratou E; Huber R; Böck A
[NiFe]-Hydrogenase maturation endopeptidase: structure and function.
Biochemical Society transactions 2005;33(Pt 1):108-11.
2005: Siwanowicz Igor; Popowicz Grzegorz M; Wisniewska Magdalena; Huber Robert; Kuenkele Klaus-Peter; Lang Kurt; Engh Richard A; Holak Tad A
Structural basis for the regulation of insulin-like growth factors by IGF binding proteins.
Structure (London, England : 1993) 2005;13(1):155-67.
2005: Breitenlechner Christine B; Friebe Walter-Gunar; Brunet Emmanuel; Werner Guido; Graul Klaus; Thomas Ulrike; Künkele Klaus-Peter; Schäfer Wolfgang; Gassel Michael; Bossemeyer Dirk; Huber Robert; Engh Richard A; Masjost Birgit
Design and crystal structures of protein kinase B-selective inhibitors in complex with protein kinase A and mutants.
Journal of medicinal chemistry 2005;48(1):163-70.
2005: Yarim Mine; Moro Stefano; Huber Robert; Meier Peter J; Kaseda Chosei; Kashima Toru; Hagenbuch Bruno; Folkers Gerd
Application of QSAR analysis to organic anion transporting polypeptide 1a5 (Oatp1a5) substrates.
Bioorganic & medicinal chemistry 2005;13(2):463-71.
2005: Groll Michael; Huber Robert
Purification, crystallization, and X-ray analysis of the yeast 20S proteasome.
Methods in enzymology 2005;398():329-36.
2004: Wenig Katja; Chatwell Lorenz; von Pawel-Rammingen Ulrich; Björck Lars; Huber Robert; Sondermann Peter
Structure of the streptococcal endopeptidase IdeS, a cysteine proteinase with strict specificity for IgG.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(50):17371-6.
2004: Groll Michael; Huber Robert
Inhibitors of the eukaryotic 20S proteasome core particle: a structural approach.
Biochimica et biophysica acta 2004;1695(1-3):33-44.
2004: Stanitzek Susanne; Augustin Martin A; Huber Robert; Kupke Thomas; Steinbacher Stefan
Structural basis of CTP-dependent peptide bond formation in coenzyme A biosynthesis catalyzed by Escherichia coli PPC synthetase.
Structure (London, England : 1993) 2004;12(11):1977-88.
2004: Rudolph Christian; Moissl Christine; Henneberger Ruth; Huber Robert
Ecology and microbial structures of archaeal/bacterial strings-of-pearls communities and archaeal relatives thriving in cold sulfidic springs.
FEMS microbiology ecology 2004;50(1):1-11.
2004: Fischer Markus; Schott Anne-Kathrin; Römisch Werner; Ramsperger Arne; Augustin Martin; Fidler Alexander; Bacher Adelbert; Richter Gerald; Huber Robert; Eisenreich Wolfgang
Evolution of vitamin B2 biosynthesis. A novel class of riboflavin synthase in Archaea.
Journal of molecular biology 2004;343(1):267-78.
2004: Popowicz Grzegorz M; Müller Rolf; Noegel Angelika A; Schleicher Michael; Huber Robert; Holak Tad A
Molecular structure of the rod domain of dictyostelium filamin.
Journal of molecular biology 2004;342(5):1637-46.
2004: Kaiser Markus; Groll Michael; Siciliano Carlo; Assfalg-Machleidt Irmgard; Weyher Elisabeth; Kohno Jun; Milbradt Alexander G; Renner Christian; Huber Robert; Moroder Luis
Binding mode of TMC-95A analogues to eukaryotic 20S proteasome.
Chembiochem : a European journal of chemical biology 2004;5(9):1256-66.
2004: Bonin Irena; Mühlberger Rene; Bourenkov Gleb P; Huber Robert; Bacher Adelbert; Richter Gerald; Wahl Markus C
Structural basis for the interaction of Escherichia coli NusA with protein N of phage lambda.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(38):13762-7.
2004: Keil Cora; Huber Robert; Bode Wolfram; Than Manuel E
Cloning, expression, crystallization and initial crystallographic analysis of the C-terminal domain of the amyloid precursor protein APP.
Acta crystallographica. Section D, Biological crystallography 2004;60(Pt 9):1614-7.
2004: Huber R M; Stratakis D F
Molecular oncology--perspectives in lung cancer.
Lung cancer (Amsterdam, Netherlands) 2004;45 Suppl 2():S209-13.
2004: Rostock M; Huber R
Randomized and double-blind studies--demands and reality as demonstrated by two examples of mistletoe research.
Forschende Komplementärmedizin und klassische Naturheilkunde = Research in complementary and natural classical medicine 2004;11 Suppl 1():18-22.
2004: Echt Stefanie; Bauer Stefanie; Steinbacher Stefan; Huber Robert; Bacher Adelbert; Fischer Markus
Potential anti-infective targets in pathogenic yeasts: structure and properties of 3,4-dihydroxy-2-butanone 4-phosphate synthase of Candida albicans.
Journal of molecular biology 2004;341(4):1085-96.
2004: Nilsen Steven P; Chan Yick-Bun; Huber Robert; Kravitz Edward A
Gender-selective patterns of aggressive behavior in Drosophila melanogaster.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(33):12342-7.
2004: Bonin Irena; Martins Berta M; Purvanov Vladimir; Fetzner Susanne; Huber Robert; Dobbek Holger
Active site geometry and substrate recognition of the molybdenum hydroxylase quinoline 2-oxidoreductase.
Structure (London, England : 1993) 2004;12(8):1425-35.
2004: Koch Michael; Breithaupt Constanze; GerhardtHaase StefanIlka; Weber Stefan; Cushman Mark; Huber Robert; Bacher Adelbert; Fischer Markus
Structural basis of charge transfer complex formation by riboflavin bound to 6,7-dimethyl-8-ribityllumazine synthase.
European journal of biochemistry / FEBS 2004;271(15):3208-14.
2004: Comellas-Bigler Mireia; Maskos Klaus; Huber Robert; Oyama Hiroshi; Oda Kohei; Bode Wolfram
1.2 A crystal structure of the serine carboxyl proteinase pro-kumamolisin; structure of an intact pro-subtilase.
Structure (London, England : 1993) 2004;12(7):1313-23.
2004: Laupitz Ralf; Hecht Stefan; Amslinger Sabine; Zepeck Ferdinand; Kaiser Johannes; Richter Gerald; Schramek Nicholas; Steinbacher Stefan; Huber Robert; Arigoni Duilio; Bacher Adelbert; Eisenreich Wolfgang; Rohdich Felix
Biochemical characterization of Bacillus subtilis type II isopentenyl diphosphate isomerase, and phylogenetic distribution of isoprenoid biosynthesis pathways.
European journal of biochemistry / FEBS 2004;271(13):2658-69.
2004: Grimm Rudolf; Huber Robert; Neumeier Thomas; Seidl Andreas; Haslbeck Martin; Seibert Fabian S
A rapid method for analyzing recombinant protein inclusion bodies by mass spectrometry.
Analytical biochemistry 2004;330(1):140-4.
2004: Breitenlechner Christine; Engh Richard A; Huber Robert; Kinzel Volker; Bossemeyer Dirk; Gassel Michael
The typically disordered N-terminus of PKA can fold as a helix and project the myristoylation site into solution.
Biochemistry 2004;43(24):7743-9.
2004: Bauer Stefanie; Schott Ann-Kathrin; Illarionova Victoria; Bacher Adelbert; Huber Robert; Fischer Markus
Biosynthesis of tetrahydrofolate in plants: crystal structure of 7,8-dihydroneopterin aldolase from Arabidopsis thaliana reveals a novel adolase class.
Journal of molecular biology 2004;339(4):967-79.
2004: Bader Gerd; Gomez-Ortiz Mariola; Haussmann Christoph; Bacher Adelbert; Huber Robert; Fischer Markus
Structure of the molybdenum-cofactor biosynthesis protein MoaB of Escherichia coli.
Acta crystallographica. Section D, Biological crystallography 2004;60(Pt 6):1068-75.
2004: Bae Jae Hyun; Paramita Pal Prajna; Moroder Luis; Huber Robert; Budisa Nediljko
Crystallographic evidence for isomeric chromophores in 3-fluorotyrosyl-green fluorescent protein.
Chembiochem : a European journal of chemical biology 2004;5(5):720-2.
2004: Gassel Michael; Breitenlechner Christine B; König Norbert; Huber Robert; Engh Richard A; Bossemeyer Dirk
The protein kinase C inhibitor bisindolyl maleimide 2 binds with reversed orientations to different conformations of protein kinase A.
The Journal of biological chemistry 2004;279(22):23679-90.
2004: Fritze Iris M; Linden Lars; Freigang Jörg; Auerbach Günter; Huber Robert; Steinbacher Stefan
The crystal structures of Zea mays and Arabidopsis 4-hydroxyphenylpyruvate dioxygenase.
Plant physiology 2004;134(4):1388-400.
2004: Koch Michael; Breithaupt Constanze; Kiefersauer Reiner; Freigang Jörg; Huber Robert; Messerschmidt Albrecht
Crystal structure of protoporphyrinogen IX oxidase: a key enzyme in haem and chlorophyll biosynthesis.
The EMBO journal 2004;23(8):1720-8.
2004: Than Manuel E; Helm Michael; Simpson David J; Lottspeich Friedrich; Huber Robert; Gietl Christine
The 2.0 A crystal structure and substrate specificity of the KDEL-tailed cysteine endopeptidase functioning in programmed cell death of Ricinus communis endosperm.
Journal of molecular biology 2004;336(5):1103-16.
2004: Breitenlechner Christine B; Wegge Thomas; Berillon Laurent; Graul Klaus; Marzenell Klaus; Friebe Walter-Gunar; Thomas Ulrike; Schumacher Ralf; Huber Robert; Engh Richard A; Masjost Birgit
Structure-based optimization of novel azepane derivatives as PKB inhibitors.
Journal of medicinal chemistry 2004;47(6):1375-90.
2004: Fischer R; Lang S M; Leitl M; Thiere M; Steiner U; Huber R M
Theophylline and acetazolamide reduce sleep-disordered breathing at high altitude.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2004;23(1):47-52.
2004: Henke M O; Lang S M; Fischer R; Landgraf R; Huber R M; Bertele-Harms R M; Harms H K
[Diagnosis and therapy of cystic fibrosis-related diabetes]
Pneumologie (Stuttgart, Germany) 2004;58(1):36-9.
2004: Gamarra F; Lingk P; Marmarova A; Edelmann M; Hautmann H; Stepp H; Baumgartner R; Huber R M
5-Aminolevulinic acid-induced fluorescence in bronchial tumours: dependency on the patterns of tumour invasion.
Journal of photochemistry and photobiology. B, Biology 2004;73(1-2):35-42.
2004: Svetlitchnyi Vitali; Dobbek Holger; Meyer-Klaucke Wolfram; Meins Thomas; Thiele Bärbel; Römer Piero; Huber Robert; Meyer Ortwin
A functional Ni-Ni-[4Fe-4S] cluster in the monomeric acetyl-CoA synthase from Carboxydothermus hydrogenoformans.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(2):446-51.
2004: Kim Jeong-Sun; Kluskens Leon D; de Vos Willem M; Huber Robert; van der Oost John
Crystal structure of fervidolysin from Fervidobacterium pennivorans, a keratinolytic enzyme related to subtilisin.
Journal of molecular biology 2004;335(3):787-97.
2004: Fischer R; Vollmar C; Thiere M; Born C; Leitl M; Pfluger T; Huber R M
No evidence of cerebral oedema in severe acute mountain sickness.
Cephalalgia : an international journal of headache 2004;24(1):66-71.
2003: Fischer Markus; Schott Ann-Kathrin; Kemter Kristina; Feicht Richard; Richter Gerald; Illarionov Boris; Eisenreich Wolfgang; Gerhardt Stefan; Cushman Mark; Steinbacher Stefan; Huber Robert; Bacher Adelbert
Riboflavin synthase of Schizosaccharomyces pombe. Protein dynamics revealed by 19F NMR protein perturbation experiments.
BMC biochemistry 2003;4():18.
2003: Kravitz Edward A; Huber Robert
Aggression in invertebrates.
Current opinion in neurobiology 2003;13(6):736-43.
2003: Breitenlechner Christine; Gassel Michael; Hidaka Hiroyoshi; Kinzel Volker; Huber Robert; Engh Richard A; Bossemeyer Dirk
Protein kinase A in complex with Rho-kinase inhibitors Y-27632, Fasudil, and H-1152P: structural basis of selectivity.
Structure (London, England : 1993) 2003;11(12):1595-607.
2003: Krapp Stephan; Münster-Kühnel Anja K; Kaiser Jens T; Huber Robert; Tiralongo Joe; Gerardy-Schahn Rita; Jacob Uwe
The crystal structure of murine CMP-5-N-acetylneuraminic acid synthetase.
Journal of molecular biology 2003;334(4):625-37.
2003: Friedrich Rainer; Panizzi Peter; Fuentes-Prior Pablo; Richter Klaus; Verhamme Ingrid; Anderson Patricia J; Kawabata Shun-Ichiro; Huber Robert; Bode Wolfram; Bock Paul E
Staphylocoagulase is a prototype for the mechanism of cofactor-induced zymogen activation.
Nature 2003;425(6957):535-9.
2003: Almeida Maria Gabriela; Macieira Sofia; Gonçalves Luisa L; Huber Robert; Cunha Carlos A; Romão Maria João; Costa Cristina; Lampreia Jorge; Moura José J G; Moura Isabel
The isolation and characterization of cytochrome c nitrite reductase subunits (NrfA and NrfH) from Desulfovibrio desulfuricans ATCC 27774. Re-evaluation of the spectroscopic data and redox properties.
European journal of biochemistry / FEBS 2003;270(19):3904-15.
2003: Steinbacher Stefan; Schiffmann Susanne; Richter Gerald; Huber Robert; Bacher Adelbert; Fischer Markus
Structure of 3,4-dihydroxy-2-butanone 4-phosphate synthase from Methanococcus jannaschii in complex with divalent metal ions and the substrate ribulose 5-phosphate: implications for the catalytic mechanism.
The Journal of biological chemistry 2003;278(43):42256-65.
2003: Macieira Sofia; Martins Berta M; Huber Robert
Oxygen-dependent coproporphyrinogen-III oxidase from Escherichia coli: one-step purification and biochemical characterisation.
FEMS microbiology letters 2003;226(1):31-7.
2003: Jozic Daniela; Kaiser Jens T; Huber Robert; Bode Wolfram; Maskos Klaus
X-ray structure of isoaspartyl dipeptidase from E.coli: a dinuclear zinc peptidase evolved from amidohydrolases.
Journal of molecular biology 2003;332(1):243-56.
2003: Gerhardt Stefan; Echt Stefanie; Busch Marco; Freigang Jörg; Auerbach Günter; Bader Gerd; Martin William F; Bacher Adelbert; Huber Robert; Fischer Markus
Structure and properties of an engineered transketolase from maize.
Plant physiology 2003;132(4):1941-9.
2003: Blaesse Michael; Kupke Thomas; Huber Robert; Steinbacher Stefan
Structure of MrsD, an FAD-binding protein of the HFCD family.
Acta crystallographica. Section D, Biological crystallography 2003;59(Pt 8):1414-21.
2003: Breithaupt Constanze; Schubart Anna; Zander Hilke; Skerra Arne; Huber Robert; Linington Christopher; Jacob Uwe
Structural insights into the antigenicity of myelin oligodendrocyte glycoprotein.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(16):9446-51.
2003: Wendt Kerstin S; Schall Iris; Huber Robert; Buckel Wolfgang; Jacob Uwe
Crystal structure of the carboxyltransferase subunit of the bacterial sodium ion pump glutaconyl-coenzyme A decarboxylase.
The EMBO journal 2003;22(14):3493-502.
2003: Henrich Stefan; Cameron Angus; Bourenkov Gleb P; Kiefersauer Reiner; Huber Robert; Lindberg Iris; Bode Wolfram; Than Manuel E
The crystal structure of the proprotein processing proteinase furin explains its stringent specificity.
Nature structural biology 2003;10(7):520-6.
2003: Gassel Michael; Breitenlechner Christine B; Rüger Petra; Jucknischke Ute; Schneider Thorsten; Huber Robert; Bossemeyer Dirk; Engh Richard A
Mutants of protein kinase A that mimic the ATP-binding site of protein kinase B (AKT).
Journal of molecular biology 2003;329(5):1021-34.
2003: Steinbacher Stefan; Kaiser Johannes; Gerhardt Stefan; Eisenreich Wolfgang; Huber Robert; Bacher Adelbert; Rohdich Felix
Crystal structure of the type II isopentenyl diphosphate:dimethylallyl diphosphate isomerase from Bacillus subtilis.
Journal of molecular biology 2003;329(5):973-82.
2003: Stratakis D F; Huber R M
[Asthma attack out of control--what to do? Therapy of acute asthma exacerbation depends on severity]
MMW Fortschritte der Medizin 2003;145(20):30-2.
2003: Bae Jae Hyun; Rubini Marina; Jung Gregor; Wiegand Georg; Seifert Markus H J; Azim M Kamran; Kim Jeong Sun; Zumbusch Andreas; Holak Tad A; Moroder Luis; Huber Robert; Budisa Nediljko
Expansion of the genetic code enables design of a novel "gold" class of green fluorescent proteins.
Journal of molecular biology 2003;328(5):1071-81.
2003: Augustin Martin A; Reichert Andreas S; Betat Heike; Huber Robert; Mörl Mario; Steegborn Clemens
Crystal structure of the human CCA-adding enzyme: insights into template-independent polymerization.
Journal of molecular biology 2003;328(5):985-94.
2003: Groll Michael; Huber Robert
Substrate access and processing by the 20S proteasome core particle.
The international journal of biochemistry & cell biology 2003;35(5):606-16.
2003: Steinbacher Stefan; Kaiser Johannes; Eisenreich Wolfgang; Huber Robert; Bacher Adelbert; Rohdich Felix
Structural basis of fosmidomycin action revealed by the complex with 2-C-methyl-D-erythritol 4-phosphate synthase (IspC). Implications for the catalytic mechanism and anti-malaria drug development.
The Journal of biological chemistry 2003;278(20):18401-7.
2003: Cunha Carlos A; Macieira Sofia; Dias João M; Almeida Gabriela; Goncalves Luisa L; Costa Cristina; Lampreia Jorge; Huber Robert; Moura José J G; Moura Isabel; Romão Maria João
Cytochrome c nitrite reductase from Desulfovibrio desulfuricans ATCC 27774. The relevance of the two calcium sites in the structure of the catalytic subunit (NrfA).
The Journal of biological chemistry 2003;278(19):17455-65.
2003: Declerck Nathalie; Machius Mischa; Joyet Philippe; Wiegand Georg; Huber Robert; Gaillardin Claude
Hyperthermostabilization of Bacillus licheniformis alpha-amylase and modulation of its stability over a 50 degrees C temperature range.
Protein engineering 2003;16(4):287-93.
2003: Engel Michael; Hoffmann Torsten; Wagner Leona; Wermann Michael; Heiser Ulrich; Kiefersauer Reiner; Huber Robert; Bode Wolfram; Demuth Hans-Ulrich; Brandstetter Hans
The crystal structure of dipeptidyl peptidase IV (CD26) reveals its functional regulation and enzymatic mechanism.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(9):5063-8.
2003: Messerschmidt Albrecht; Worbs Michael; Steegborn Clemens; Wahl Markus C; Huber Robert; Laber Bernd; Clausen Tim
Determinants of enzymatic specificity in the Cys-Met-metabolism PLP-dependent enzymes family: crystal structure of cystathionine gamma-lyase from yeast and intrafamiliar structure comparison.
Biological chemistry 2003;384(3):373-86.
2003: Peng Guohong; Fritzsch Günter; Zickermann Volker; Schägger Hermann; Mentele Reinhardt; Lottspeich Friedrich; Bostina Mihnea; Radermacher Michael; Huber Robert; Stetter Karl Otto; Michel Hartmut
Isolation, characterization and electron microscopic single particle analysis of the NADH:ubiquinone oxidoreductase (complex I) from the hyperthermophilic eubacterium Aquifex aeolicus.
Biochemistry 2003;42(10):3032-9.
2003: Steinbacher Stefan; Hernández-Acosta Pilar; Bieseler Bastian; Blaesse Michael; Huber Robert; Culiáñez-Macià Francisco Antonio; Kupke Thomas
Crystal structure of the plant PPC decarboxylase AtHAL3a complexed with an ene-thiol reaction intermediate.
Journal of molecular biology 2003;327(1):193-202.
2003: Groll Michael; Brandstetter Hans; Bartunik Hans; Bourenkow Gleb; Huber Robert
Investigations on the maturation and regulation of archaebacterial proteasomes.
Journal of molecular biology 2003;327(1):75-83.
2003: Bauer Stefanie; Kemter Kristina; Bacher Adelbert; Huber Robert; Fischer Markus; Steinbacher Stefan
Crystal structure of Schizosaccharomyces pombe riboflavin kinase reveals a novel ATP and riboflavin-binding fold.
Journal of molecular biology 2003;326(5):1463-73.
2003: Machius Mischa; Declerck Nathalie; Huber Robert; Wiegand Georg
Kinetic stabilization of Bacillus licheniformis alpha-amylase through introduction of hydrophobic residues at the surface.
The Journal of biological chemistry 2003;278(13):11546-53.
2003: Huber R; Nauck M; Lüdtke R; Scharnagl H
Effects of one week juice fasting on lipid metabolism: a cohort study in healthy subjects.
Forschende Komplementärmedizin und klassische Naturheilkunde = Research in complementary and natural classical medicine 2003;10(1):7-10.
2003: Fischer Markus; Haase Ilka; Kis Klaus; Meining Winfried; Ladenstein Rudolf; Cushman Mark; Schramek Nicholas; Huber Robert; Bacher Adelbert
Enzyme catalysis via control of activation entropy: site-directed mutagenesis of 6,7-dimethyl-8-ribityllumazine synthase.
Journal of molecular biology 2003;326(3):783-93.
2003: Rebelo Jorge; Auerbach Günter; Bader Gerd; Bracher Andreas; Nar Herbert; Hösl Cornelia; Schramek Nicholas; Kaiser Johannes; Bacher Adelbert; Huber Robert; Fischer Markus
Biosynthesis of pteridines. Reaction mechanism of GTP cyclohydrolase I.
Journal of molecular biology 2003;326(2):503-16.
2003: Sichler Katrin; Kopetzki Erhard; Huber Robert; Bode Wolfram; Hopfner Karl-Peter; Brandstetter Hans
Physiological fIXa activation involves a cooperative conformational rearrangement of the 99-loop.
The Journal of biological chemistry 2003;278(6):4121-6.
2003: Krapp S; Mimura Y; Jefferis R; Huber R; Sondermann P
Structural analysis of human IgG-Fc glycoforms reveals a correlation between glycosylation and structural integrity.
Journal of molecular biology 2003;325(5):979-89.
2003: Kaiser Jens T; Bruno Stefano; Clausen Tim; Huber Robert; Schiaretti Francesca; Mozzarelli Andrea; Kessler Dorothea
Snapshots of the cystine lyase C-DES during catalysis. Studies in solution and in the crystalline state.
The Journal of biological chemistry 2003;278(1):357-65.
2003: Hofmann Andreas; Huber Robert
Liposomes in assessment of annexin-membrane interactions.
Methods in enzymology 2003;372():186-216.
2003: Song Hyun Kyu; Bochtler Matthias; Azim M Kamran; Hartmann Claudia; Huber Robert; Ramachandran Ravishankar
Isolation and characterization of the prokaryotic proteasome homolog HslVU (ClpQY) from Thermotoga maritima and the crystal structure of HslV.
Biophysical chemistry 2003;100(1-3):437-52.
2002: Dobbek Holger; Gremer Lothar; Kiefersauer Reiner; Huber Robert; Meyer Ortwin
Catalysis at a dinuclear [CuSMo(==O)OH] cluster in a CO dehydrogenase resolved at 1.1-A resolution.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(25):15971-6.
2002: Kim Jeong Sun; Groll Michael; Musiol Hans Jürgen; Behrendt Raymond; Kaiser Markus; Moroder Luis; Huber Robert; Brandstetter Hans
Navigation inside a protease: substrate selection and product exit in the tricorn protease from Thermoplasma acidophilum.
Journal of molecular biology 2002;324(5):1041-50.
2002: Rehm Till; Huber Robert; Holak Tad A
Application of NMR in structural proteomics: screening for proteins amenable to structural analysis.
Structure (London, England : 1993) 2002;10(12):1613-8.
2002: Budisa Nediljko; Rubini Marina; Bae Jae H; Weyher Elisabeth; Wenger Waltraud; Golbik Ralph; Huber Robert; Moroder Luis
Global replacement of tryptophan with aminotryptophans generates non-invasive protein-based optical pH sensors.
Angewandte Chemie (International ed. in English) 2002;41(21):4066-9.
2002: Fischer Markus; Romisch Werner; Schiffmann Susanne; Kelly Mark; Oschkinat Hartmut; Steinbacher Stefan; Huber Robert; Eisenreich Wolfgang; Richter Gerald; Bacher Adelbert
Biosynthesis of riboflavin in archaea studies on the mechanism of 3,4-dihydroxy-2-butanone-4-phosphate synthase of Methanococcus jannaschii.
The Journal of biological chemistry 2002;277(44):41410-6.
2002: Sichler Katrin; Hopfner Karl Peter; Kopetzki Erhard; Huber Robert; Bode Wolfram; Brandstetter Hans
The influence of residue 190 in the S1 site of trypsin-like serine proteases on substrate selectivity is universally conserved.
FEBS letters 2002;530(1-3):220-4.
2002: Gerhardt Stefan; Schott Ann-Kathrin; Kairies Norman; Cushman Mark; Illarionov Boris; Eisenreich Wolfgang; Bacher Adelbert; Huber Robert; Steinbacher Stefan; Fischer Markus
Studies on the reaction mechanism of riboflavin synthase: X-ray crystal structure of a complex with 6-carboxyethyl-7-oxo-8-ribityllumazine.
Structure (London, England : 1993) 2002;10(10):1371-81.
2002: Goettig Peter; Groll Michael; Kim Jeong-Sun; Huber Robert; Brandstetter Hans
Structures of the tricorn-interacting aminopeptidase F1 with different ligands explain its catalytic mechanism.
The EMBO journal 2002;21(20):5343-52.
2002: Cushman Mark; Yang Donglai; Mihalic Jeffrey T; Chen Jinhua; Gerhardt Stefan; Huber Robert; Fischer Markus; Kis Klaus; Bacher Adelbert
Incorporation of an amide into 5-phosphonoalkyl-6-D-ribitylaminopyrimidinedione lumazine synthase inhibitors results in an unexpected reversal of selectivity for riboflavin synthase vs lumazine synthase.
The Journal of organic chemistry 2002;67(20):6871-7.
2002: Einsle Oliver; Messerschmidt Albrecht; Huber Robert; Kroneck Peter M H; Neese Frank
Mechanism of the six-electron reduction of nitrite to ammonia by cytochrome c nitrite reductase.
Journal of the American Chemical Society 2002;124(39):11737-45.
2002: Sichler Katrin; Banner David W; D'Arcy Allan; Hopfner Karl-Peter; Huber Robert; Bode Wolfram; Kresse Georg-Burkhard; Kopetzki Erhard; Brandstetter Hans
Crystal structures of uninhibited factor VIIa link its cofactor and substrate-assisted activation to specific interactions.
Journal of molecular biology 2002;322(3):591-603.
2002: Raaijmakers Hans; Macieira Sofia; Dias João M; Teixeira Susana; Bursakov Sergey; Huber Robert; Moura José J G; Moura Isabel; Romão Maria J
Gene sequence and the 1.8 A crystal structure of the tungsten-containing formate dehydrogenase from Desulfovibrio gigas.
Structure (London, England : 1993) 2002;10(9):1261-72.
2002: Steiner Thomas; Kaiser Jens T; Marinkoviç Snezan; Huber Robert; Wahl Markus C
Crystal structures of transcription factor NusG in light of its nucleic acid- and protein-binding activities.
The EMBO journal 2002;21(17):4641-53.
2002: Lang S M; Stratakis D F; Henke M; Otto B; Huber R M
[Intratracheal tumor? A rare etiology]
Der Internist 2002;43(8):999-1002.
2002: Garrido-Franco Marta; Laber Bernd; Huber Robert; Clausen Tim
Enzyme-ligand complexes of pyridoxine 5'-phosphate synthase: implications for substrate binding and catalysis.
Journal of molecular biology 2002;321(4):601-12.
2002: Jozic Daniela; Bourenkow Gleb; Bartunik Hans; Scholze Henning; Dive Vincent; Henrich Bernhard; Huber Robert; Bode Wolfram; Maskos Klaus
Crystal structure of the dinuclear zinc aminopeptidase PepV from Lactobacillus delbrueckii unravels its preference for dipeptides.
Structure (London, England : 1993) 2002;10(8):1097-106.
2002: Marquardt Ulf; Zettl Frank; Huber Robert; Bode Wolfram; Sommerhoff Christian
The crystal structure of human alpha1-tryptase reveals a blocked substrate-binding region.
Journal of molecular biology 2002;321(3):491-502.
2002: Atzenhofer Werner; Regelsberger Günther; Jacob Uwe; Peschek Günter; Furtmüller Paul; Huber Robert; Obinger Christian
The 2.0A resolution structure of the catalytic portion of a cyanobacterial membrane-bound manganese superoxide dismutase.
Journal of molecular biology 2002;321(3):479-89.
2002: Cushman Mark; Yang Donglai; Gerhardt Stefan; Huber Robert; Fischer Markus; Kis Klaus; Bacher Adelbert
Design, synthesis, and evaluation of 6-carboxyalkyl and 6-phosphonoxyalkyl derivatives of 7-oxo-8-ribitylaminolumazines as inhibitors of riboflavin synthase and lumazine synthase.
The Journal of organic chemistry 2002;67(16):5807-16.
2002: Braun Nathalie; Meining Winfried; Hars Ulrike; Fischer Markus; Ladenstein Rudolf; Huber Robert; Bacher Adelbert; Weinkauf Sevil; Bachmann Luis
Formation of metal nanoclusters on specific surface sites of protein molecules.
Journal of molecular biology 2002;321(2):341-53.
2002: Rieger J; Linsenmaier U; Hautmann H; Fedorowski A; Huber R M; Pfeifer K J
[Interdisciplinary interventional therapy for tracheobronchial stenosis with modern metal net stents]
RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin 2002;174(8):1009-14.
2002: Brandstetter Hans; Kim Jeong-Sun; Groll Michael; Göttig Peter; Huber Robert
Structural basis for the processive protein degradation by tricorn protease.
Biological chemistry 2002;383(7-8):1157-65.
2002: Cha Hyunju; Kopetzki Erhard; Huber Robert; Lanzendörfer Martin; Brandstetter Hans
Structural basis of the adaptive molecular recognition by MMP9.
Journal of molecular biology 2002;320(5):1065-79.
2002: Comellas-Bigler Mireia; Fuentes-Prior Pablo; Maskos Klaus; Huber Robert; Oyama Hiroshi; Uchida Kenichi; Dunn Ben M; Oda Kohei; Bode Wolfram
The 1.4 a crystal structure of kumamolysin: a thermostable serine-carboxyl-type proteinase.
Structure (London, England : 1993) 2002;10(6):865-76.
2002: Gerhardt Stefan; Haase Ilka; Steinbacher Stefan; Kaiser Jens T; Cushman Mark; Bacher Adelbert; Huber Robert; Fischer Markus
The structural basis of riboflavin binding to Schizosaccharomyces pombe 6,7-dimethyl-8-ribityllumazine synthase.
Journal of molecular biology 2002;318(5):1317-29.
2002: Ramachandran Ravishankar; Hartmann Claudia; Song Hyun Kyu; Huber Robert; Bochtler Matthias
Functional interactions of HslV (ClpQ) with the ATPase HslU (ClpY).
Proceedings of the National Academy of Sciences of the United States of America 2002;99(11):7396-401.
2002: Groll Michael; Nazif Tamim; Huber Robert; Bogyo Matthew
Probing structural determinants distal to the site of hydrolysis that control substrate specificity of the 20S proteasome.
Chemistry & biology 2002;9(5):655-62.
2002: Than Manuel E; Henrich Stefan; Huber Robert; Ries Albert; Mann Karlheinz; Kühn Klaus; Timpl Rupert; Bourenkov Gleb P; Bartunik Hans D; Bode Wolfram
The 1.9-A crystal structure of the noncollagenous (NC1) domain of human placenta collagen IV shows stabilization via a novel type of covalent Met-Lys cross-link.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(10):6607-12.
2002: Seifert Markus H J; Breitenlechner Christine B; Bossemeyer Dirk; Huber Robert; Holak Tad A; Engh Richard A
Phosphorylation and flexibility of cyclic-AMP-dependent protein kinase (PKA) using (31)P NMR spectroscopy.
Biochemistry 2002;41(19):5968-77.
2002: Klein R; Classen K; Berg P A; Lüdtke R; Werner M; Huber R
In vivo-induction of antibodies to mistletoe lectin-1 and viscotoxin by exposure to aqueous mistletoe extracts: a randomised double-blinded placebo controlled phase I study in healthy individuals.
European journal of medical research 2002;7(4):155-63.
2002: Chen Selby; Lee Ann Yeelin; Bowens Nina M; Huber Robert; Kravitz Edward A
Fighting fruit flies: a model system for the study of aggression.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(8):5664-8.
2002: Garrido-Franco Marta; Ehlert Stephan; Messerschmidt Albrecht; Marinkovic' Snezan; Huber Robert; Laber Bernd; Bourenkov Gleb P; Clausen Tim
Structure and function of threonine synthase from yeast.
The Journal of biological chemistry 2002;277(14):12396-405.
2002: Kaiser Markus; Groll Michael; Renner Christian; Huber Robert; Moroder Luis
The core structure of TMC-95A is a promising lead for reversible proteasome inhibition.
Angewandte Chemie (International ed. in English) 2002;41(5):780-3.
2002: Krojer Tobias; Garrido-Franco Marta; Huber Robert; Ehrmann Michael; Clausen Tim
Crystal structure of DegP (HtrA) reveals a new protease-chaperone machine.
Nature 2002;416(6879):455-9.
2002: Friedrich Rainer; Steinmetzer Torsten; Huber Robert; Stürzebecher Jörg; Bode Wolfram
The methyl group of N(alpha)(Me)Arg-containing peptides disturbs the active-site geometry of thrombin, impairing efficient cleavage.
Journal of molecular biology 2002;316(4):869-74.
2002: Schramek Nicholas; Bracher Andreas; Fischer Markus; Auerbach Günter; Nar Herbert; Huber Robert; Bacher Adelbert
Reaction mechanism of GTP cyclohydrolase I: single turnover experiments using a kinetically competent reaction intermediate.
Journal of molecular biology 2002;316(3):829-37.
2002: Scheide Dierk; Huber Robert; Friedrich Thorsten
The proton-pumping NADH:ubiquinone oxidoreductase (complex I) of Aquifex aeolicus.
FEBS letters 2002;512(1-3):80-4.
2002: Richardson John L; Fuentes-Prior Pablo; Sadler J Evan; Huber Robert; Bode Wolfram
Characterization of the residues involved in the human alpha-thrombin-haemadin complex: an exosite II-binding inhibitor.
Biochemistry 2002;41(8):2535-42.
2002: Grazulis Saulius; Deibert Markus; Rimseliene Renata; Skirgaila Remigijus; Sasnauskas Giedrius; Lagunavicius Arunas; Repin Vladimir; Urbanke Claus; Huber Robert; Siksnys Virginijus
Crystal structure of the Bse634I restriction endonuclease: comparison of two enzymes recognizing the same DNA sequence.
Nucleic acids research 2002;30(4):876-85.
2002: Fischer Markus; Haase Ilka; Feicht Richard; Richter Gerald; Gerhardt Stefan; Changeux Jean-Pierre; Huber Robert; Bacher Adelbert
Biosynthesis of riboflavin: 6,7-dimethyl-8-ribityllumazine synthase of Schizosaccharomyces pombe.
European journal of biochemistry / FEBS 2002;269(2):519-26.
2002: Friedrich Rainer; Fuentes-Prior Pablo; Ong Edgar; Coombs Gary; Hunter Michael; Oehler Ryan; Pierson Diane; Gonzalez Richard; Huber Robert; Bode Wolfram; Madison Edwin L
Catalytic domain structures of MT-SP1/matriptase, a matrix-degrading transmembrane serine proteinase.
The Journal of biological chemistry 2002;277(3):2160-8.
2002: Dobbek Holger; Huber Robert
The molybdenum and tungsten cofactors: a crystallographic view.
Metal ions in biological systems 2002;39():227-63.
2001: Huber R; Klein R; Lüdtke R; Werner M
[Frequency of the common cold in healthy subjects during exposure to a lectin-rich and a lectin-poor mistletoe preparation in a randomized, double-blind, placebo-controlled study]
Forschende Komplementärmedizin und klassische Naturheilkunde = Research in complementary and natural classical medicine 2001;8(6):354-8.
2001: Riedl S J; Fuentes-Prior P; Renatus M; Kairies N; Krapp S; Huber R; Salvesen G S; Bode W
Structural basis for the activation of human procaspase-7.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(26):14790-5.
2001: Song H K; Mulrooney S B; Huber R; Hausinger R P
Crystal structure of Klebsiella aerogenes UreE, a nickel-binding metallochaperone for urease activation.
The Journal of biological chemistry 2001;276(52):49359-64.
2001: Brandstetter H; Kim J S; Groll M; Huber R
Crystal structure of the tricorn protease reveals a protein disassembly line.
Nature 2001;414(6862):466-70.
2001: Steegborn C; Danot O; Huber R; Clausen T
Crystal structure of transcription factor MalT domain III: a novel helix repeat fold implicated in regulated oligomerization.
Structure (London, England : 1993) 2001;9(11):1051-60.
2001: Kairies N; Beisel H G; Fuentes-Prior P; Tsuda R; Muta T; Iwanaga S; Bode W; Huber R; Kawabata S
The 2.0-A crystal structure of tachylectin 5A provides evidence for the common origin of the innate immunity and the blood coagulation systems.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(24):13519-24.
2001: Ullrich T C; Huber R
The complex structures of ATP sulfurylase with thiosulfate, ADP and chlorate reveal new insights in inhibitory effects and the catalytic cycle.
Journal of molecular biology 2001;313(5):1117-25.
2001: Martins B M; Grimm B; Mock H P; Richter G; Huber R; Messerschmidt A
Tobacco uroporphyrinogen-III decarboxylase: characterization, crystallization and preliminary X-ray analysis.
Acta crystallographica. Section D, Biological crystallography 2001;57(Pt 11):1709-11.
2001: Martins B M; Grimm B; Mock H P; Huber R; Messerschmidt A
Crystal structure and substrate binding modeling of the uroporphyrinogen-III decarboxylase from Nicotiana tabacum. Implications for the catalytic mechanism.
The Journal of biological chemistry 2001;276(47):44108-16.
2001: Rebelo J M; Dias J M; Huber R; Moura J J; Romão M J
Structure refinement of the aldehyde oxidoreductase from Desulfovibrio gigas (MOP) at 1.28 A.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2001;6(8):791-800.
2001: Estébanez-Perpiñá E; Bayés A; Vendrell J; Jongsma M A; Bown D P; Gatehouse J A; Huber R; Bode W; Avilés F X; Reverter D
Crystal structure of a novel mid-gut procarboxypeptidase from the cotton pest Helicoverpa armigera.
Journal of molecular biology 2001;313(3):629-38.
2001: Bader G; Schiffmann S; Herrmann A; Fischer M; Gütlich M; Auerbach G; Ploom T; Bacher A; Huber R; Lemm T
Crystal structure of rat GTP cyclohydrolase I feedback regulatory protein, GFRP.
Journal of molecular biology 2001;312(5):1051-7.
2001: Klein C; Georges G; Künkele K P; Huber R; Engh R A; Hansen S
High thermostability and lack of cooperative DNA binding distinguish the p63 core domain from the homologous tumor suppressor p53.
The Journal of biological chemistry 2001;276(40):37390-401.
2001: Bochtler M; Song H K; Hartmann C; Ramachandran R; Huber R
The quaternary arrangement of HslU and HslV in a cocrystal: a response to Wang, Yale.
Journal of structural biology 2001;135(3):281-93.
2001: Macedo-Ribeiro S; Martins B M; Pereira P J; Buse G; Huber R; Soulimane T
New insights into the thermostability of bacterial ferredoxins: high-resolution crystal structure of the seven-iron ferredoxin from Thermus thermophilus.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2001;6(7):663-74.
2001: Huber R; Lüdtke R; Klassen M; Müller-Buscher G; Wolff-Vorbeck G; Scheer R
Effects of a mistletoe preparation with defined lectin content on chronic hepatitis C: an individually controlled cohort study.
European journal of medical research 2001;6(9):399-405.
2001: Lang R; Kocourek A; Braun M; Tschesche H; Huber R; Bode W; Maskos K
Substrate specificity determinants of human macrophage elastase (MMP-12) based on the 1.1 A crystal structure.
Journal of molecular biology 2001;312(4):731-42.
2001: Wendt K S; Vodermaier H C; Jacob U; Gieffers C; Gmachl M; Peters J M; Huber R; Sondermann P
Crystal structure of the APC10/DOC1 subunit of the human anaphase-promoting complex.
Nature structural biology 2001;8(9):784-8.
2001: Steegborn C; Laber B; Messerschmidt A; Huber R; Clausen T
Crystal structures of cystathionine gamma-synthase inhibitor complexes rationalize the increased affinity of a novel inhibitor.
Journal of molecular biology 2001;311(4):789-801.
2001: Dobbek H; Svetlitchnyi V; Gremer L; Huber R; Meyer O
Crystal structure of a carbon monoxide dehydrogenase reveals a [Ni-4Fe-5S] cluster.
Science (New York, N.Y.) 2001;293(5533):1281-5.
2001: Groll M; Koguchi Y; Huber R; Kohno J
Crystal structure of the 20 S proteasome:TMC-95A complex: a non-covalent proteasome inhibitor.
Journal of molecular biology 2001;311(3):543-8.
2001: Astner S T; Huber R M
[Drug therapy of obstructive lung diseases]
Der Internist 2001;42(7):1040-9.
2001: Hautmann H; Gamarra F; Pfeifer K J; Huber R M
Fiberoptic bronchoscopic balloon dilatation in malignant tracheobronchial disease: indications and results.
Chest 2001;120(1):43-9.
2001: Zeslawski W; Beisel H G; Kamionka M; Kalus W; Engh R A; Huber R; Lang K; Holak T A
The interaction of insulin-like growth factor-I with the N-terminal domain of IGFBP-5.
The EMBO journal 2001;20(14):3638-44.
2001: Budisa N; Alefelder S; Bae J H; Golbik R; Minks C; Huber R; Moroder L
Proteins with beta-(thienopyrrolyl)alanines as alternative chromophores and pharmaceutically active amino acids.
Protein science : a publication of the Protein Society 2001;10(7):1281-92.
2001: Worbs M; Bourenkov G P; Bartunik H D; Huber R; Wahl M C
An extended RNA binding surface through arrayed S1 and KH domains in transcription factor NusA.
Molecular cell 2001;7(6):1177-89.
2001: Breitinger U; Clausen T; Ehlert S; Huber R; Laber B; Schmidt F; Pohl E; Messerschmidt A
The three-dimensional structure of cystathionine beta-lyase from Arabidopsis and its substrate specificity.
Plant physiology 2001;126(2):631-42.
2001: Bae J H; Alefelder S; Kaiser J T; Friedrich R; Moroder L; Huber R; Budisa N
Incorporation of beta-selenolo[3,2-b]pyrrolyl-alanine into proteins for phase determination in protein X-ray crystallography.
Journal of molecular biology 2001;309(4):925-36.
2001: Breithaupt C; Strassner J; Breitinger U; Huber R; Macheroux P; Schaller A; Clausen T
X-ray structure of 12-oxophytodienoate reductase 1 provides structural insight into substrate binding and specificity within the family of OYE.
Structure (London, England : 1993) 2001;9(5):419-29.
2001: Brandstetter H; Grams F; Glitz D; Lang A; Huber R; Bode W; Krell H W; Engh R A
The 1.8-A crystal structure of a matrix metalloproteinase 8-barbiturate inhibitor complex reveals a previously unobserved mechanism for collagenase substrate recognition.
The Journal of biological chemistry 2001;276(20):17405-12.
2001: Köhler A; Bajorek M; Groll M; Moroder L; Rubin D M; Huber R; Glickman M H; Finley D
The substrate translocation channel of the proteasome.
Biochimie 2001;83(3-4):325-32.
2001: Franco M G; Laber B; Huber R; Clausen T
Structural basis for the function of pyridoxine 5'-phosphate synthase.
Structure (London, England : 1993) 2001;9(3):245-53.
2001: Dorowski A; Hofmann A; Steegborn C; Boicu M; Huber R
Crystal structure of paprika ferredoxin-NADP+ reductase. Implications for the electron transfer pathway.
The Journal of biological chemistry 2001;276(12):9253-63.
2001: Ullrich T C; Blaesse M; Huber R
Crystal structure of ATP sulfurylase from Saccharomyces cerevisiae, a key enzyme in sulfate activation.
The EMBO journal 2001;20(3):316-29.
2001: Augustin M A; Huber R; Kaiser J T
Crystal structure of a DNA-dependent RNA polymerase (DNA primase).
Nature structural biology 2001;8(1):57-61.
2001: Kawabata S; Beisel H G; Huber R; Bode W; Gokudan S; Muta T; Tsuda R; Koori K; Kawahara T; Seki N; Mizunoe Y; Wai S N; Iwanaga S
Role of tachylectins in host defense of the Japanese horseshoe crab Tachypleus tridentatus.
Advances in experimental medicine and biology 2001;484():195-202.
2000: Estébanez-Perpiña E; Fuentes-Prior P; Belorgey D; Braun M; Kiefersauer R; Maskos K; Huber R; Rubin H; Bode W
Crystal structure of the caspase activator human granzyme B, a proteinase highly specific for an Asp-P1 residue.
Biological chemistry 2000;381(12):1203-14.
2000: Song H K; Hartmann C; Ramachandran R; Bochtler M; Behrendt R; Moroder L; Huber R
Mutational studies on HslU and its docking mode with HslV.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(26):14103-8.
2000: Garbuglia M; Verzini M; Hofmann A; Huber R; Donato R
S100A1 and S100B interactions with annexins.
Biochimica et biophysica acta 2000;1498(2-3):192-206.
2000: Blaesse M; Kupke T; Huber R; Steinbacher S
Crystal structure of the peptidyl-cysteine decarboxylase EpiD complexed with a pentapeptide substrate.
The EMBO journal 2000;19(23):6299-310.
2000: Auerbach G; Herrmann A; Bracher A; Bader G; Gutlich M; Fischer M; Neukamm M; Garrido-Franco M; Richardson J; Nar H; Huber R; Bacher A
Zinc plays a key role in human and bacterial GTP cyclohydrolase I.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(25):13567-72.
2000: Einsle O; Stach P; Messerschmidt A; Simon J; Kröger A; Huber R; Kroneck P M
Cytochrome c nitrite reductase from Wolinella succinogenes. Structure at 1.6 A resolution, inhibitor binding, and heme-packing motifs.
The Journal of biological chemistry 2000;275(50):39608-16.
2000: Soulimane T; Than M E; Dewor M; Huber R; Buse G
Primary structure of a novel subunit in ba3-cytochrome oxidase from Thermus thermophilus.
Protein science : a publication of the Protein Society 2000;9(11):2068-73.
2000: Groll M; Bajorek M; Köhler A; Moroder L; Rubin D M; Huber R; Glickman M H; Finley D
A gated channel into the proteasome core particle.
Nature structural biology 2000;7(11):1062-7.
2000: Richardson J L; Kröger B; Hoeffken W; Sadler J E; Pereira P; Huber R; Bode W; Fuentes-Prior P
Crystal structure of the human alpha-thrombin-haemadin complex: an exosite II-binding inhibitor.
The EMBO journal 2000;19(21):5650-60.
2000: Meyer O; Gremer L; Ferner R; Ferner M; Dobbek H; Gnida M; Meyer-Klaucke W; Huber R
The role of Se, Mo and Fe in the structure and function of carbon monoxide dehydrogenase.
Biological chemistry 2000;381(9-10):865-76.
2000: Hänzelmann P; Dobbek H; Gremer L; Huber R; Meyer O
The effect of intracellular molybdenum in Hydrogenophaga pseudoflava on the crystallographic structure of the seleno-molybdo-iron-sulfur flavoenzyme carbon monoxide dehydrogenase.
Journal of molecular biology 2000;301(5):1221-35.
2000: Deibert M; Grazulis S; Sasnauskas G; Siksnys V; Huber R
Structure of the tetrameric restriction endonuclease NgoMIV in complex with cleaved DNA.
Nature structural biology 2000;7(9):792-9.
2000: Huber R; Barth H; Schmitt-Gräff A; Klein R
Hypereosinophilia induced by high-dose intratumoral and peritumoral mistletoe application to a patient with pancreatic carcinoma.
Journal of alternative and complementary medicine (New York, N.Y.) 2000;6(4):305-10.
2000: Declerck N; Machius M; Wiegand G; Huber R; Gaillardin C
Probing structural determinants specifying high thermostability in Bacillus licheniformis alpha-amylase.
Journal of molecular biology 2000;301(4):1041-57.
2000: Lang S M; Stratakis D F; Freudling A; Ebelt K; Oduncu F; Hautmann H; Huber R M
Detection of K-ras and p53 mutations in bronchoscopically obtained malignant and non-malignant tissue from patients with non-small cell lung cancer.
European journal of medical research 2000;5(8):341-6.
2000: Garrido Franco M; Huber R; Schmidt F S; Laber B; Clausen T
Crystallization and preliminary X-ray crystallographic analysis of PdxJ, the pyridoxine 5'-phosphate synthesizing enzyme.
Acta crystallographica. Section D, Biological crystallography 2000;56(Pt 8):1045-8.
2000: Minks C; Huber R; Moroder L; Budisa N
Noninvasive tracing of recombinant proteins with "fluorophenylalanine-fingers".
Analytical biochemistry 2000;284(1):29-34.
2000: Hautmann H; Hefele S; Schotten K; Huber R M
Maximal inspiratory mouth pressures (PIMAX) in healthy subjects--what is the lower limit of normal?
Respiratory medicine 2000;94(7):689-93.
2000: Sondermann P; Huber R; Oosthuizen V; Jacob U
The 3.2-A crystal structure of the human IgG1 Fc fragment-Fc gammaRIII complex.
Nature 2000;406(6793):267-73.
2000: Krupka H I; Huber R; Holt S C; Clausen T
Crystal structure of cystalysin from Treponema denticola: a pyridoxal 5'-phosphate-dependent protein acting as a haemolytic enzyme.
The EMBO journal 2000;19(13):3168-78.
2000: Hofmann A; Raguénès-Nicol C; Favier-Perron B; Mesonero J; Huber R; Russo-Marie F; Lewit-Bentley A
The annexin A3-membrane interaction is modulated by an N-terminal tryptophan.
Biochemistry 2000;39(26):7712-21.
2000: Hautmann H; Gamarra F; Henke M; Diehm S; Huber R M
High frequency jet ventilation in interventional fiberoptic bronchoscopy.
Anesthesia and analgesia 2000;90(6):1436-40.
2000: Sperl S; Jacob U; Arroyo de Prada N; Stürzebecher J; Wilhelm O G; Bode W; Magdolen V; Huber R; Moroder L
(4-aminomethyl)phenylguanidine derivatives as nonpeptidic highly selective inhibitors of human urokinase.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(10):5113-8.
2000: Walter M C; Lochmüller H; Reilich P; Klopstock T; Huber R; Hartard M; Hennig M; Pongratz D; Müller-Felber W
Creatine monohydrate in muscular dystrophies: A double-blind, placebo-controlled clinical study.
Neurology 2000;54(9):1848-50.
2000: Rester U; Moser M; Huber R; Bode W
L-Isoaspartate 115 of porcine beta-trypsin promotes crystallization of its complex with bdellastasin.
Acta crystallographica. Section D, Biological crystallography 2000;56(Pt 5):581-8.
2000: Soulimane T; Buse G; Bourenkov G P; Bartunik H D; Huber R; Than M E
Structure and mechanism of the aberrant ba(3)-cytochrome c oxidase from thermus thermophilus.
The EMBO journal 2000;19(8):1766-76.
2000: Clausen T; Kaiser J T; Steegborn C; Huber R; Kessler D
Crystal structure of the cystine C-S lyase from Synechocystis: stabilization of cysteine persulfide for FeS cluster biosynthesis.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(8):3856-61.
2000: Reverter D; Fernández-Catalán C; Baumgartner R; Pfänder R; Huber R; Bode W; Vendrell J; Holak T A; Avilés F X
Structure of a novel leech carboxypeptidase inhibitor determined free in solution and in complex with human carboxypeptidase A2.
Nature structural biology 2000;7(4):322-8.
2000: Schuler B; Fürst F; Osterroth F; Steinbacher S; Huber R; Seckler R
Plasticity and steric strain in a parallel beta-helix: rational mutations in the P22 tailspike protein.
Proteins 2000;39(1):89-101.
2000: Theodoratou E; Paschos A; Magalon A; Fritsche E; Huber R; Böck A
Nickel serves as a substrate recognition motif for the endopeptidase involved in hydrogenase maturation.
European journal of biochemistry / FEBS 2000;267(7):1995-9.
2000: Wahl M C; Huber R; Marinkoviç S; Weyher-Stingl E; Ehlert S
Structural investigations of the highly flexible recombinant ribosomal protein L12 from Thermotoga maritima.
Biological chemistry 2000;381(3):221-9.
2000: Fuentes-Prior P; Iwanaga Y; Huber R; Pagila R; Rumennik G; Seto M; Morser J; Light D R; Bode W
Structural basis for the anticoagulant activity of the thrombin-thrombomodulin complex.
Nature 2000;404(6777):518-25.
2000: Loidl G; Musiol H J; Budisa N; Huber R; Poirot S; Fourmy D; Moroder L
Synthesis of beta-(1-azulenyl)-L-alanine as a potential blue-colored fluorescent tryptophan analog and its use in peptide synthesis.
Journal of peptide science : an official publication of the European Peptide Society 2000;6(3):139-44.
2000: Dams T; Auerbach G; Bader G; Jacob U; Ploom T; Huber R; Jaenicke R
The crystal structure of dihydrofolate reductase from Thermotoga maritima: molecular features of thermostability.
Journal of molecular biology 2000;297(3):659-72.
2000: Kaiser J T; Clausen T; Bourenkow G P; Bartunik H D; Steinbacher S; Huber R
Crystal structure of a NifS-like protein from Thermotoga maritima: implications for iron sulphur cluster assembly.
Journal of molecular biology 2000;297(2):451-64.
2000: Hofmann A; Proust J; Dorowski A; Schantz R; Huber R
Annexin 24 from Capsicum annuum. X-ray structure and biochemical characterization.
The Journal of biological chemistry 2000;275(11):8072-82.
2000: Bode W; Huber R
Structural basis of the endoproteinase-protein inhibitor interaction.
Biochimica et biophysica acta 2000;1477(1-2):241-52.
2000: Rebelo J; Macieira S; Dias J M; Huber R; Ascenso C S; Rusnak F; Moura J J; Moura I; Romão M J
Gene sequence and crystal structure of the aldehyde oxidoreductase from Desulfovibrio desulfuricans ATCC 27774.
Journal of molecular biology 2000;297(1):135-46.
2000: Worbs M; Huber R; Wahl M C
Crystal structure of ribosomal protein L4 shows RNA-binding sites for ribosome incorporation and feedback control of the S10 operon.
The EMBO journal 2000;19(5):807-18.
2000: Hautmann H; Bauer M; Pfeifer K J; Huber R M
Flexible bronchoscopy: a safe method for metal stent implantation in bronchial disease.
The Annals of thoracic surgery 2000;69(2):398-401.
2000: Bochtler M; Hartmann C; Song H K; Bourenkov G P; Bartunik H D; Huber R
The structures of HsIU and the ATP-dependent protease HsIU-HsIV.
Nature 2000;403(6771):800-5.
2000: Duarte R O; Archer M; Dias J M; Bursakov S; Huber R; Moura I; Romão M J; Moura J J
Biochemical/spectroscopic characterization and preliminary X-ray analysis of a new aldehyde oxidoreductase isolated from Desulfovibrio desulfuricans ATCC 27774.
Biochemical and biophysical research communications 2000;268(3):745-9.
2000: Fischer R; Lang S M; Steiner U; Toepfer M; Hautmann H; Pongratz H; Huber R M
Theophylline improves acute mountain sickness.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2000;15(1):123-7.
2000: Loidl G; Musiol H J; Groll M; Huber R; Moroder L
Synthesis of bivalent inhibitors of eucaryotic proteasomes.
Journal of peptide science : an official publication of the European Peptide Society 2000;6(1):36-46.
2000: Strobl S; Fernandez-Catalan C; Braun M; Huber R; Masumoto H; Nakagawa K; Irie A; Sorimachi H; Bourenkow G; Bartunik H; Suzuki K; Bode W
The crystal structure of calcium-free human m-calpain suggests an electrostatic switch mechanism for activation by calcium.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(2):588-92.
2000: Wahl M C; Bourenkov G P; Bartunik H D; Huber R
Flexibility, conformational diversity and two dimerization modes in complexes of ribosomal protein L12.
The EMBO journal 2000;19(2):174-86.
2000: Gremer L; Kellner S; Dobbek H; Huber R; Meyer O
Binding of flavin adenine dinucleotide to molybdenum-containing carbon monoxide dehydrogenase from Oligotropha carboxidovorans. Structural and functional analysis of a carbon monoxide dehydrogenase species in which the native flavoprotein has been replaced by its recombinant counterpart produced in Escherichia coli.
The Journal of biological chemistry 2000;275(3):1864-72.
1999: Stratakis D F; Lang S M; Eichenlaub S; Löscher T; Stein R; Huber R M
[Pulmonary trichomoniasis: diagnosis based on identification of irritation in bronchoalveolar lavage]
Pneumologie (Stuttgart, Germany) 1999;53(12):617-9.
1999: Huber R M; Astner S T
[Increased incidence of bronchial carcinomas. What is new in therapy and diagnosis?]
MMW Fortschritte der Medizin 1999;141(47):24-8.
1999: Macedo-Ribeiro S; Bode W; Huber R; Quinn-Allen M A; Kim S W; Ortel T L; Bourenkov G P; Bartunik H D; Stubbs M T; Kane W H; Fuentes-Prior P
Crystal structures of the membrane-binding C2 domain of human coagulation factor V.
Nature 1999;402(6760):434-9.
1999: Deibert M; Grazulis S; Janulaitis A; Siksnys V; Huber R
Crystal structure of MunI restriction endonuclease in complex with cognate DNA at 1.7 A resolution.
The EMBO journal 1999;18(21):5805-16.
1999: Clausen T; Wahl M C; Messerschmidt A; Huber R; Fuhrmann J C; Laber B; Streber W; Steegborn C
Cloning, purification and characterisation of cystathionine gamma-synthase from Nicotiana tabacum.
Biological chemistry 1999;380(10):1237-42.
1999: Baxa U; Steinbacher S; Weintraub A; Huber R; Seckler R
Mutations improving the folding of phage P22 tailspike protein affect its receptor binding activity.
Journal of molecular biology 1999;293(3):693-701.
1999: Eichinger A; Beisel H G; Jacob U; Huber R; Medrano F J; Banbula A; Potempa J; Travis J; Bode W
Crystal structure of gingipain R: an Arg-specific bacterial cysteine proteinase with a caspase-like fold.
The EMBO journal 1999;18(20):5453-62.
1999: Rester U; Bode W; Moser M; Parry M A; Huber R; Auerswald E
Structure of the complex of the antistasin-type inhibitor bdellastasin with trypsin and modelling of the bdellastasin-microplasmin system.
Journal of molecular biology 1999;293(1):93-106.
1999: Siksnys V; Skirgaila R; Sasnauskas G; Urbanke C; Cherny D; Grazulis S; Huber R
The Cfr10I restriction enzyme is functional as a tetramer.
Journal of molecular biology 1999;291(5):1105-18.
1999: Pereira P J; Lozanov V; Patthy A; Huber R; Bode W; Pongor S; Strobl S
Specific inhibition of insect alpha-amylases: yellow meal worm alpha-amylase in complex with the amaranth alpha-amylase inhibitor at 2.0 A resolution.
Structure (London, England : 1993) 1999;7(9):1079-88.
1999: Groll M; Heinemeyer W; Jäger S; Ullrich T; Bochtler M; Wolf D H; Huber R
The catalytic sites of 20S proteasomes and their role in subunit maturation: a mutational and crystallographic study.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(20):10976-83.
1999: Hopfner K P; Lang A; Karcher A; Sichler K; Kopetzki E; Brandstetter H; Huber R; Bode W; Engh R A
Coagulation factor IXa: the relaxed conformation of Tyr99 blocks substrate binding.
Structure (London, England : 1993) 1999;7(8):989-96.
1999: Jäger S; Groll M; Huber R; Wolf D H; Heinemeyer W
Proteasome beta-type subunits: unequal roles of propeptides in core particle maturation and a hierarchy of active site function.
Journal of molecular biology 1999;291(4):997-1013.
1999: Minks C; Huber R; Moroder L; Budisa N
Atomic mutations at the single tryptophan residue of human recombinant annexin V: effects on structure, stability, and activity.
Biochemistry 1999;38(33):10649-59.
1999: Dobbek H; Gremer L; Meyer O; Huber R
Crystal structure and mechanism of CO dehydrogenase, a molybdo iron-sulfur flavoprotein containing S-selanylcysteine.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(16):8884-9.
1999: Al-Batran S E; Astner S T; Supthut M; Gamarra F; Brueckner K; Welsch U; Knuechel R; Huber R M
Three-dimensional in vitro cocultivation of lung carcinoma cells with human bronchial organ culture as a model for bronchial carcinoma.
American journal of respiratory cell and molecular biology 1999;21(2):200-8.
1999: Einsle O; Messerschmidt A; Stach P; Bourenkov G P; Bartunik H D; Huber R; Kroneck P M
Structure of cytochrome c nitrite reductase.
Nature 1999;400(6743):476-80.
1999: Schnackenberg J; Than M E; Mann K; Wiegand G; Huber R; Reuter W
Amino acid sequence, crystallization and structure determination of reduced and oxidized cytochrome c6 from the green alga Scenedesmus obliquus.
Journal of molecular biology 1999;290(5):1019-30.
1999: Steegborn C; Messerschmidt A; Laber B; Streber W; Huber R; Clausen T
The crystal structure of cystathionine gamma-synthase from Nicotiana tabacum reveals its substrate and reaction specificity.
Journal of molecular biology 1999;290(5):983-96.
1999: Bracher A; Fischer M; Eisenreich W; Ritz H; Schramek N; Boyle P; Gentili P; Huber R; Nar H; Auerbach G; Bacher A
Histidine 179 mutants of GTP cyclohydrolase I catalyze the formation of 2-amino-5-formylamino-6-ribofuranosylamino-4(3H)-pyrimidinone triphosphate.
The Journal of biological chemistry 1999;274(24):16727-35.
1999: Steinbacher S; Hof P; Eichinger L; Schleicher M; Gettemans J; Vandekerckhove J; Huber R; Benz J
The crystal structure of the Physarum polycephalum actin-fragmin kinase: an atypical protein kinase with a specialized substrate-binding domain.
The EMBO journal 1999;18(11):2923-9.
1999: Ploom T; Haussmann C; Hof P; Steinbacher S; Bacher A; Richardson J; Huber R
Crystal structure of 7,8-dihydroneopterin triphosphate epimerase.
Structure (London, England : 1993) 1999;7(5):509-16.
1999: Fritsche E; Paschos A; Beisel H G; Böck A; Huber R
Crystal structure of the hydrogenase maturating endopeptidase HYBD from Escherichia coli.
Journal of molecular biology 1999;288(5):989-98.
1999: Loidl G; Groll M; Musiol H J; Huber R; Moroder L
Bivalency as a principle for proteasome inhibition.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(10):5418-22.
1999: Beisel H G; Kawabata S; Iwanaga S; Huber R; Bode W
Tachylectin-2: crystal structure of a specific GlcNAc/GalNAc-binding lectin involved in the innate immunity host defense of the Japanese horseshoe crab Tachypleus tridentatus.
The EMBO journal 1999;18(9):2313-22.
1999: Steegborn C; Clausen T; Sondermann P; Jacob U; Worbs M; Marinkovic S; Huber R; Wahl M C
Kinetics and inhibition of recombinant human cystathionine gamma-lyase. Toward the rational control of transsulfuration.
The Journal of biological chemistry 1999;274(18):12675-84.
1999: Loidl G; Groll M; Musiol H J; Ditzel L; Huber R; Moroder L
Bifunctional inhibitors of the trypsin-like activity of eukaryotic proteasomes.
Chemistry & biology 1999;6(4):197-204.
1999: Hopfner K P; Eichinger A; Engh R A; Laue F; Ankenbauer W; Huber R; Angerer B
Crystal structure of a thermostable type B DNA polymerase from Thermococcus gorgonarius.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(7):3600-5.
1999: Hautmann H; Rieger J; Huber R M; Pfeifer K J
Elastic deformation properties of implanted endobronchial wire stents in benign and malignant bronchial disease: A radiographic in vivo evaluation.
Cardiovascular and interventional radiology 1999;22(2):103-8.
1999: Sondermann P; Huber R; Jacob U
Crystal structure of the soluble form of the human fcgamma-receptor IIb: a new member of the immunoglobulin superfamily at 1.7 A resolution.
The EMBO journal 1999;18(5):1095-103.
1999: Ploom T; Thöny B; Yim J; Lee S; Nar H; Leimbacher W; Richardson J; Huber R; Auerbach G
Crystallographic and kinetic investigations on the mechanism of 6-pyruvoyl tetrahydropterin synthase.
Journal of molecular biology 1999;286(3):851-60.
1999: Reuter W; Wiegand G; Huber R; Than M E
Structural analysis at 2.2 A of orthorhombic crystals presents the asymmetry of the allophycocyanin-linker complex, AP.LC7.8, from phycobilisomes of Mastigocladus laminosus.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(4):1363-8.
1999: Pereira P J; Wang Z M; Rubin H; Huber R; Bode W; Schechter N M; Strobl S
The 2.2 A crystal structure of human chymase in complex with succinyl-Ala-Ala-Pro-Phe-chloromethylketone: structural explanation for its dipeptidyl carboxypeptidase specificity.
Journal of molecular biology 1999;286(1):163-73.
1999: Dias J M; Than M E; Humm A; Huber R; Bourenkov G P; Bartunik H D; Bursakov S; Calvete J; Caldeira J; Carneiro C; Moura J J; Moura I; Romão M J
Crystal structure of the first dissimilatory nitrate reductase at 1.9 A solved by MAD methods.
Structure (London, England : 1993) 1999;7(1):65-79.
1999: Fritsche E; Humm A; Huber R
The ligand-induced structural changes of human L-Arginine:Glycine amidinotransferase. A mutational and crystallographic study.
The Journal of biological chemistry 1999;274(5):3026-32.
1999: Budisa N; Minks C; Alefelder S; Wenger W; Dong F; Moroder L; Huber R
Toward the experimental codon reassignment in vivo: protein building with an expanded amino acid repertoire.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1999;13(1):41-51.
1999: Bochtler M; Ditzel L; Groll M; Hartmann C; Huber R
The proteasome.
Annual review of biophysics and biomolecular structure 1999;28():295-317.
1998: Fritsche E; Bergner A; Humm A; Piepersberg W; Huber R
Crystal structure of L-arginine:inosamine-phosphate amidinotransferase StrB1 from Streptomyces griseus: an enzyme involved in streptomycin biosynthesis.
Biochemistry 1998;37(51):17664-72.
1998: Renatus M; Bode W; Huber R; Stürzebecher J; Stubbs M T
Structural and functional analyses of benzamidine-based inhibitors in complex with trypsin: implications for the inhibition of factor Xa, tPA, and urokinase.
Journal of medicinal chemistry 1998;41(27):5445-56.
1998: Clausen T; Huber R; Prade L; Wahl M C; Messerschmidt A
Crystal structure of Escherichia coli cystathionine gamma-synthase at 1.5 A resolution.
The EMBO journal 1998;17(23):6827-38.
1998: Prade L; Huber R; Bieseler B
Structures of herbicides in complex with their detoxifying enzyme glutathione S-transferase - explanations for the selectivity of the enzyme in plants.
Structure (London, England : 1993) 1998;6(11):1445-52.
1998: Lang S M; Astner S; Fischer R; Schiffl H; Huber R M
Dissociation between high anti-PR3 titers (c-ANCA) and the clinical course of disease in a case of Wegener granulomatosis.
Wiener klinische Wochenschrift 1998;110(19):691-4.
1998: Parry M A; Fernandez-Catalan C; Bergner A; Huber R; Hopfner K P; Schlott B; Gührs K H; Bode W
The ternary microplasmin-staphylokinase-microplasmin complex is a proteinase-cofactor-substrate complex in action.
Nature structural biology 1998;5(10):917-23.
1998: Baumgartner R; Fernandez-Catalan C; Winoto A; Huber R; Engh R A; Holak T A
Structure of human cyclin-dependent kinase inhibitor p19INK4d: comparison to known ankyrin-repeat-containing structures and implications for the dysfunction of tumor suppressor p16INK4a.
Structure (London, England : 1993) 1998;6(10):1279-90.
1998: Nussbaum A K; Dick T P; Keilholz W; Schirle M; Stevanovic S; Dietz K; Heinemeyer W; Groll M; Wolf D H; Huber R; Rammensee H G; Schild H
Cleavage motifs of the yeast 20S proteasome beta subunits deduced from digests of enolase 1.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(21):12504-9.
1998: Dick T P; Nussbaum A K; Deeg M; Heinemeyer W; Groll M; Schirle M; Keilholz W; Stevanovic S; Wolf D H; Huber R; Rammensee H G; Schild H
Contribution of proteasomal beta-subunits to the cleavage of peptide substrates analyzed with yeast mutants.
The Journal of biological chemistry 1998;273(40):25637-46.
1998: Parry M A; Jacob U; Huber R; Wisner A; Bon C; Bode W
The crystal structure of the novel snake venom plasminogen activator TSV-PA: a prototype structure for snake venom serine proteinases.
Structure (London, England : 1993) 1998;6(9):1195-206.
1998: Banbula A; Potempa J; Travis J; Fernandez-Catalán C; Mann K; Huber R; Bode W; Medrano F
Amino-acid sequence and three-dimensional structure of the Staphylococcus aureus metalloproteinase at 1.72 A resolution.
Structure (London, England : 1993) 1998;6(9):1185-93.
1998: Fernandez-Catalan C; Bode W; Huber R; Turk D; Calvete J J; Lichte A; Tschesche H; Maskos K
Crystal structure of the complex formed by the membrane type 1-matrix metalloproteinase with the tissue inhibitor of metalloproteinases-2, the soluble progelatinase A receptor.
The EMBO journal 1998;17(17):5238-48.
1998: Hopfner K P; Kopetzki E; Kresse G B; Bode W; Huber R; Engh R A
New enzyme lineages by subdomain shuffling.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(17):9813-8.
1998: Strobl S; Maskos K; Wiegand G; Huber R; Gomis-Rüth F X; Glockshuber R
A novel strategy for inhibition of alpha-amylases: yellow meal worm alpha-amylase in complex with the Ragi bifunctional inhibitor at 2.5 A resolution.
Structure (London, England : 1993) 1998;6(7):911-21.
1998: Megli F M; Selvaggi M; Liemann S; Quagliariello E; Huber R
The calcium-dependent binding of annexin V to phospholipid vesicles influences the bilayer inner fluidity gradient.
Biochemistry 1998;37(29):10540-6.
1998: Auerbach G; Ostendorp R; Prade L; Korndörfer I; Dams T; Huber R; Jaenicke R
Lactate dehydrogenase from the hyperthermophilic bacterium thermotoga maritima: the crystal structure at 2.1 A resolution reveals strategies for intrinsic protein stabilization.
Structure (London, England : 1993) 1998;6(6):769-81.
1998: Brandstetter H; Engh R A; Von Roedern E G; Moroder L; Huber R; Bode W; Grams F
Structure of malonic acid-based inhibitors bound to human neutrophil collagenase. A new binding mode explains apparently anomalous data.
Protein science : a publication of the Protein Society 1998;7(6):1303-9.
1998: Ditzel L; Huber R; Mann K; Heinemeyer W; Wolf D H; Groll M
Conformational constraints for protein self-cleavage in the proteasome.
Journal of molecular biology 1998;279(5):1187-91.
1998: Skirgaila R; Grazulis S; Bozic D; Huber R; Siksnys V
Structure-based redesign of the catalytic/metal binding site of Cfr10I restriction endonuclease reveals importance of spatial rather than sequence conservation of active centre residues.
Journal of molecular biology 1998;279(2):473-81.
1998: Strobl S; Maskos K; Betz M; Wiegand G; Huber R; Gomis-Rüth F X; Glockshuber R
Crystal structure of yellow meal worm alpha-amylase at 1.64 A resolution.
Journal of molecular biology 1998;278(3):617-28.
1998: Glatigny A; Hof P; Romão M J; Huber R; Scazzocchio C
Altered specificity mutations define residues essential for substrate positioning in xanthine dehydrogenase.
Journal of molecular biology 1998;278(2):431-8.
1998: Budisa N; Huber R; Golbik R; Minks C; Weyher E; Moroder L
Atomic mutations in annexin V--thermodynamic studies of isomorphous protein variants.
European journal of biochemistry / FEBS 1998;253(1):1-9.
1998: Ditzel L; Löwe J; Stock D; Stetter K O; Huber H; Huber R; Steinbacher S
Crystal structure of the thermosome, the archaeal chaperonin and homolog of CCT.
Cell 1998;93(1):125-38.
1998: Machius M; Declerck N; Huber R; Wiegand G
Activation of Bacillus licheniformis alpha-amylase through a disorder-->order transition of the substrate-binding site mediated by a calcium-sodium-calcium metal triad.
Structure (London, England : 1993) 1998;6(3):281-92.
1998: Becker M; Stubbs M T; Huber R
Crystallization of phycoerythrin 545 of Rhodomonas lens using detergents and unusual additives.
Protein science : a publication of the Protein Society 1998;7(3):580-6.
1998: Pereira P J; Bergner A; Macedo-Ribeiro S; Huber R; Matschiner G; Fritz H; Sommerhoff C P; Bode W
Human beta-tryptase is a ring-like tetramer with active sites facing a central pore.
Nature 1998;392(6673):306-11.
1998: Messerschmidt A; Prade L; Kroes S J; Sanders-Loehr J; Huber R; Canters G W
Rack-induced metal binding vs. flexibility: Met121His azurin crystal structures at different pH.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(7):3443-8.
1998: Maskos K; Fernandez-Catalan C; Huber R; Bourenkov G P; Bartunik H; Ellestad G A; Reddy P; Wolfson M F; Rauch C T; Castner B J; Davis R; Clarke H R; Petersen M; Fitzner J N; Cerretti D P; March C J; Paxton R J; Black R A; Bode W
Crystal structure of the catalytic domain of human tumor necrosis factor-alpha-converting enzyme.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(7):3408-12.
1998: Beermann ofm cap B B; Hinz H J; Hofmann A; Huber R
Acid induced equilibrium unfolding of annexin V wild type shows two intermediate states.
FEBS letters 1998;423(2):265-9.
1998: Molitor M; Dahl C; Molitor I; Schäfer U; Speich N; Huber R; Deutzmann R; Trüper H G
A dissimilatory sirohaem-sulfite-reductase-type protein from the hyperthermophilic archaeon Pyrobaculum islandicum.
Microbiology (Reading, England) 1998;144 ( Pt 2)():529-41.
1998: Gomis-Rüth F X; Gómez-Ortiz M; Vendrell J; Ventura S; Bode W; Huber R; Avilés F X
Cutting at the right place--the importance of selective limited proteolysis in the activation of proproteinase E.
European journal of biochemistry / FEBS 1998;251(3):839-44.
1998: Hofmann A; Escherich A; Lewit-Bentley A; Benz J; Raguenes-Nicol C; Russo-Marie F; Gerke V; Moroder L; Huber R
Interactions of benzodiazepine derivatives with annexins.
The Journal of biological chemistry 1998;273(5):2885-94.
1998: Budisa N; Minks C; Medrano F J; Lutz J; Huber R; Moroder L
Residue-specific bioincorporation of non-natural, biologically active amino acids into proteins as possible drug carriers: structure and stability of the per-thiaproline mutant of annexin V.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(2):455-9.
1998: Ribeiro R C; Apriletti J W; Wagner R L; West B L; Feng W; Huber R; Kushner P J; Nilsson S; Scanlan T; Fletterick R J; Schaufele F; Baxter J D
Mechanisms of thyroid hormone action: insights from X-ray crystallographic and functional studies.
Recent progress in hormone research 1998;53():351-92; discussion 392-4.
1997: Prade L; Engh R A; Girod A; Kinzel V; Huber R; Bossemeyer D
Staurosporine-induced conformational changes of cAMP-dependent protein kinase catalytic subunit explain inhibitory potential.
Structure (London, England : 1993) 1997;5(12):1627-37.
1997: Blickling S; Beisel H G; Bozic D; Knäblein J; Laber B; Huber R
Structure of dihydrodipicolinate synthase of Nicotiana sylvestris reveals novel quaternary structure.
Journal of molecular biology 1997;274(4):608-21.
1997: Neuefeind T; Huber R; Reinemer P; Knäblein J; Prade L; Mann K; Bieseler B
Cloning, sequencing, crystallization and X-ray structure of glutathione S-transferase-III from Zea mays var. mutin: a leading enzyme in detoxification of maize herbicides.
Journal of molecular biology 1997;274(4):577-87.
1997: Neuefeind T; Huber R; Dasenbrock H; Prade L; Bieseler B
Crystal structure of herbicide-detoxifying maize glutathione S-transferase-I in complex with lactoylglutathione: evidence for an induced-fit mechanism.
Journal of molecular biology 1997;274(4):446-53.
1997: Hofmann A; Benz J; Liemann S; Huber R
Voltage dependent binding of annexin V, annexin VI and annexin VII-core to acidic phospholipid membranes.
Biochimica et biophysica acta 1997;1330(2):254-64.
1997: Auerbach G; Herrmann A; Gütlich M; Fischer M; Jacob U; Bacher A; Huber R
The 1.25 A crystal structure of sepiapterin reductase reveals its binding mode to pterins and brain neurotransmitters.
The EMBO journal 1997;16(24):7219-30.
1997: Auerbach G; Huber R; Grättinger M; Zaiss K; Schurig H; Jaenicke R; Jacob U
Closed structure of phosphoglycerate kinase from Thermotoga maritima reveals the catalytic mechanism and determinants of thermal stability.
Structure (London, England : 1993) 1997;5(11):1475-83.
1997: Hopfner K P; Brandstetter H; Karcher A; Kopetzki E; Huber R; Engh R A; Bode W
Converting blood coagulation factor IXa into factor Xa: dramatic increase in amidolytic activity identifies important active site determinants.
The EMBO journal 1997;16(22):6626-35.
1997: Renatus M; Stubbs M T; Huber R; Bringmann P; Donner P; Schleuning W D; Bode W
Catalytic domain structure of vampire bat plasminogen activator: a molecular paradigm for proteolysis without activation cleavage.
Biochemistry 1997;36(44):13483-93.
1997: Clausen T; Huber R; Messerschmidt A; Pohlenz H D; Laber B
Slow-binding inhibition of Escherichia coli cystathionine beta-lyase by L-aminoethoxyvinylglycine: a kinetic and X-ray study.
Biochemistry 1997;36(41):12633-43.
1997: Rick K; Sroka R; Stepp H; Kriegmair M; Huber R M; Jacob K; Baumgartner R
Pharmacokinetics of 5-aminolevulinic acid-induced protoporphyrin IX in skin and blood.
Journal of photochemistry and photobiology. B, Biology 1997;40(3):313-9.
1997: Prade L; Huber R; Manoharan T H; Fahl W E; Reuter W
Structures of class pi glutathione S-transferase from human placenta in complex with substrate, transition-state analogue and inhibitor.
Structure (London, England : 1993) 1997;5(10):1287-95.
1997: Fuentes-Prior P; Noeske-Jungblut C; Donner P; Schleuning W D; Huber R; Bode W
Structure of the thrombin complex with triabin, a lipocalin-like exosite-binding inhibitor derived from a triatomine bug.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(22):11845-50.
1997: Wahl M C; Huber R; Prade L; Marinkovic S; Messerschmidt A; Clausen T
Cloning, purification, crystallization, and preliminary X-ray diffraction analysis of cystathionine gamma-synthase from E. coli.
FEBS letters 1997;414(3):492-6.
1997: Gomis-Rüth F X; Maskos K; Betz M; Bergner A; Huber R; Suzuki K; Yoshida N; Nagase H; Brew K; Bourenkov G P; Bartunik H; Bode W
Mechanism of inhibition of the human matrix metalloproteinase stromelysin-1 by TIMP-1.
Nature 1997;389(6646):77-81.
1997: Escherich A; Ditzel L; Musiol H J; Groll M; Huber R; Moroder L
Synthesis, kinetic characterization and X-ray analysis of peptide aldehydes as inhibitors of the 20S proteasomes from Thermoplasma acidophilum and Saccharomyces cerevisiae.
Biological chemistry 1997;378(8):893-8.
1997: Renatus M; Engh R A; Stubbs M T; Huber R; Fischer S; Kohnert U; Bode W
Lysine 156 promotes the anomalous proenzyme activity of tPA: X-ray crystal structure of single-chain human tPA.
The EMBO journal 1997;16(16):4797-805.
1997: Soulimane T; von Walter M; Hof P; Than M E; Huber R; Buse G
Cytochrome-c552 from Thermus thermophilus: a functional and crystallographic investigation.
Biochemical and biophysical research communications 1997;237(3):572-6.
1997: Than M E; Hof P; Huber R; Bourenkov G P; Bartunik H D; Buse G; Soulimane T
Thermus thermophilus cytochrome-c552: A new highly thermostable cytochrome-c structure obtained by MAD phasing.
Journal of molecular biology 1997;271(4):629-44.
1997: Renatus M; Bode W; Huber R; Stürzebecher J; Prasa D; Fischer S; Kohnert U; Stubbs M T
Structural mapping of the active site specificity determinants of human tissue-type plasminogen activator. Implications for the design of low molecular weight substrates and inhibitors.
The Journal of biological chemistry 1997;272(35):21713-9.
1997: Stubbs M T; Morenweiser R; Stürzebecher J; Bauer M; Bode W; Huber R; Piechottka G P; Matschiner G; Sommerhoff C P; Fritz H; Auerswald E A
The three-dimensional structure of recombinant leech-derived tryptase inhibitor in complex with trypsin. Implications for the structure of human mast cell tryptase and its inhibition.
The Journal of biological chemistry 1997;272(32):19931-7.
1997: Fritsche E; Humm A; Huber R
Substrate binding and catalysis by L-arginine:glycine amidinotransferase--a mutagenesis and crystallographic study.
European journal of biochemistry / FEBS 1997;247(2):483-90.
1997: Budisa N; Karnbrock W; Steinbacher S; Humm A; Prade L; Neuefeind T; Moroder L; Huber R
Bioincorporation of telluromethionine into proteins: a promising new approach for X-ray structure analysis of proteins.
Journal of molecular biology 1997;270(4):616-23.
1997: Liemann S; Bringemeier I; Benz J; Göttig P; Hofmann A; Huber R; Noegel A A; Jacob U
Crystal structure of the C-terminal tetrad repeat from synexin (annexin VII) of Dictyostelium discoideum.
Journal of molecular biology 1997;270(1):79-88.
1997: Knäblein J; Neuefeind T; Schneider F; Bergner A; Messerschmidt A; Löwe J; Steipe B; Huber R
Ta6Br(2+)12, a tool for phase determination of large biological assemblies by X-ray crystallography.
Journal of molecular biology 1997;270(1):1-7.
1997: Avaeva S; Kurilova S; Nazarova T; Rodina E; Vorobyeva N; Sklyankina V; Grigorjeva O; Harutyunyan E; Oganessyan V; Wilson K; Dauter Z; Huber R; Mather T
Crystal structure of Escherichia coli inorganic pyrophosphatase complexed with SO4(2-). Ligand-induced molecular asymmetry.
FEBS letters 1997;410(2-3):502-8.
1997: Liemann S; Huber R
Three-dimensional structure of annexins.
Cellular and molecular life sciences : CMLS 1997;53(6):516-21.
1997: Gomis-Rüth F X; Gómez-Ortiz M; Vendrell J; Ventura S; Bode W; Huber R; Avilés F X
Crystal structure of an oligomer of proteolytic zymogens: detailed conformational analysis of the bovine ternary complex and implications for their activation.
Journal of molecular biology 1997;269(5):861-80.
1997: Humm A; Fritsche E; Steinbacher S; Huber R
Crystal structure and mechanism of human L-arginine:glycine amidinotransferase: a mitochondrial enzyme involved in creatine biosynthesis.
The EMBO journal 1997;16(12):3373-85.
1997: van de Locht A; Bode W; Huber R; Le Bonniec B F; Stone S R; Esmon C T; Stubbs M T
The thrombin E192Q-BPTI complex reveals gross structural rearrangements: implications for the interaction with antithrombin and thrombomodulin.
The EMBO journal 1997;16(11):2977-84.
1997: Harutyunyan E H; Oganessyan V Y; Oganessyan N N; Avaeva S M; Nazarova T I; Vorobyeva N N; Kurilova S A; Huber R; Mather T
Crystal structure of holo inorganic pyrophosphatase from Escherichia coli at 1.9 A resolution. Mechanism of hydrolysis.
Biochemistry 1997;36(25):7754-60.
1997: Strobl S; Gomis-Rüth F X; Maskos K; Frank G; Huber R; Glockshuber R
The alpha-amylase from the yellow meal worm: complete primary structure, crystallization and preliminary X-ray analysis.
FEBS letters 1997;409(1):109-14.
1997: Burgering M J; Orbons L P; van der Doelen A; Mulders J; Theunissen H J; Grootenhuis P D; Bode W; Huber R; Stubbs M T
The second Kunitz domain of human tissue factor pathway inhibitor: cloning, structure determination and interaction with factor Xa.
Journal of molecular biology 1997;269(3):395-407.
1997: Bochtler M; Ditzel L; Groll M; Huber R
Crystal structure of heat shock locus V (HslV) from Escherichia coli.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(12):6070-4.
1997: Declerck N; Machius M; Chambert R; Wiegand G; Huber R; Gaillardin C
Hyperthermostable mutants of Bacillus licheniformis alpha-amylase: thermodynamic studies and structural interpretation.
Protein engineering 1997;10(5):541-9.
1997: Toepfer M; Müller-Felber W; Huber R M; Held E; Wekerle G; Unger J; Schlotter B; Pongratz D
[50-year-old patient with rapid ataxia onset, generalized paresthesia and myoclonus]
Der Internist 1997;38(4):355-60.
1997: Steinbacher S; Miller S; Baxa U; Budisa N; Weintraub A; Seckler R; Huber R
Phage P22 tailspike protein: crystal structure of the head-binding domain at 2.3 A, fully refined structure of the endorhamnosidase at 1.56 A resolution, and the molecular basis of O-antigen recognition and cleavage.
Journal of molecular biology 1997;267(4):865-80.
1997: Groll M; Ditzel L; Löwe J; Stock D; Bochtler M; Bartunik H D; Huber R
Structure of 20S proteasome from yeast at 2.4 A resolution.
Nature 1997;386(6624):463-71.
1997: Humm A; Fritsche E; Mann K; Göhl M; Huber R
Recombinant expression and isolation of human L-arginine:glycine amidinotransferase and identification of its active-site cysteine residue.
The Biochemical journal 1997;322 ( Pt 3)():771-6.
1997: Jacob U; Mack M; Clausen T; Huber R; Buckel W; Messerschmidt A
Glutaconate CoA-transferase from Acidaminococcus fermentans: the crystal structure reveals homology with other CoA-transferases.
Structure (London, England : 1993) 1997;5(3):415-26.
1997: Vogl T; Jatzke C; Hinz H J; Benz J; Huber R
Thermodynamic stability of annexin V E17G: equilibrium parameters from an irreversible unfolding reaction.
Biochemistry 1997;36(7):1657-68.
1997: Hammann C; van Pouderoyen G; Nar H; Gomis Rüth F X; Messerschmidt A; Huber R; den Blaauwen T; Canters G W
Crystal structures of modified apo-His117Gly and apo-His46Gly mutants of Pseudomonas aeruginosa azurin.
Journal of molecular biology 1997;266(2):357-66.
1997: Gomez-Ortiz M; Gomis-Rüth F X; Huber R; Avilés F X
Inhibition of carboxypeptidase A by excess zinc: analysis of the structural determinants by X-ray crystallography.
FEBS letters 1997;400(3):336-40.
1997: Blickling S; Renner C; Laber B; Pohlenz H D; Holak T A; Huber R
Reaction mechanism of Escherichia coli dihydrodipicolinate synthase investigated by X-ray crystallography and NMR spectroscopy.
Biochemistry 1997;36(1):24-33.
1997: Tönsing K; Kakorin S; Neumann E; Liemann S; Huber R
Annexin V and vesicle membrane electroporation.
European biophysics journal : EBJ 1997;26(4):307-18.
1997: Huber R; Orzeszyna M; Pokorny N; Kravitz E A
Biogenic amines and aggression: experimental approaches in crustaceans.
Brain, behavior and evolution 1997;50 Suppl 1():60-8.
1996: Schmidtke G; Kraft R; Kostka S; Henklein P; Frömmel C; Löwe J; Huber R; Kloetzel P M; Schmidt M
Analysis of mammalian 20S proteasome biogenesis: the maturation of beta-subunits is an ordered two-step mechanism involving autocatalysis.
The EMBO journal 1996;15(24):6887-98.
1996: Mather T; Oganessyan V; Hof P; Huber R; Foundling S; Esmon C; Bode W
The 2.8 A crystal structure of Gla-domainless activated protein C.
The EMBO journal 1996;15(24):6822-31.
1996: Bergner A; Oganessyan V; Muta T; Iwanaga S; Typke D; Huber R; Bode W
Crystal structure of a coagulogen, the clotting protein from horseshoe crab: a structural homologue of nerve growth factor.
The EMBO journal 1996;15(24):6789-97.
1996: van de Locht A; Stubbs M T; Bode W; Friedrich T; Bollschweiler C; Höffken W; Huber R
The ornithodorin-thrombin crystal structure, a key to the TAP enigma?
The EMBO journal 1996;15(22):6011-7.
1996: Brandstetter H; Kühne A; Bode W; Huber R; von der Saal W; Wirthensohn K; Engh R A
X-ray structure of active site-inhibited clotting factor Xa. Implications for drug design and substrate recognition.
The Journal of biological chemistry 1996;271(47):29988-92.
1996: Engh R A; Brandstetter H; Sucher G; Eichinger A; Baumann U; Bode W; Huber R; Poll T; Rudolph R; von der Saal W
Enzyme flexibility, solvent and 'weak' interactions characterize thrombin-ligand interactions: implications for drug design.
Structure (London, England : 1993) 1996;4(11):1353-62.
1996: Macedo-Ribeiro S; Darimont B; Sterner R; Huber R
Small structural changes account for the high thermostability of 1[4Fe-4S] ferredoxin from the hyperthermophilic bacterium Thermotoga maritima.
Structure (London, England : 1993) 1996;4(11):1291-301.
1996: Zajc A; Romão M J; Turk B; Huber R
Crystallographic and fluorescence studies of ligand binding to N-carbamoylsarcosine amidohydrolase from Arthrobacter sp.
Journal of molecular biology 1996;263(2):269-83.
1996: Hof P; Mayr I; Huber R; Korzus E; Potempa J; Travis J; Powers J C; Bode W
The 1.8 A crystal structure of human cathepsin G in complex with Suc-Val-Pro-PheP-(OPh)2: a Janus-faced proteinase with two opposite specificities.
The EMBO journal 1996;15(20):5481-91.
1996: Pöschl E; Mayer U; Stetefeld J; Baumgartner R; Holak T A; Huber R; Timpl R
Site-directed mutagenesis and structural interpretation of the nidogen binding site of the laminin gamma1 chain.
The EMBO journal 1996;15(19):5154-9.
1996: Schneider F; Löwe J; Huber R; Schindelin H; Kisker C; Knäblein J
Crystal structure of dimethyl sulfoxide reductase from Rhodobacter capsulatus at 1.88 A resolution.
Journal of molecular biology 1996;263(1):53-69.
1996: Knäblein J; Mann K; Ehlert S; Fonstein M; Huber R; Schneider F
Isolation, cloning, sequence analysis and localization of the operon encoding dimethyl sulfoxide/trimethylamine N-oxide reductase from Rhodobacter capsulatus.
Journal of molecular biology 1996;263(1):40-52.
1996: Baxa U; Steinbacher S; Miller S; Weintraub A; Huber R; Seckler R
Interactions of phage P22 tails with their cellular receptor, Salmonella O-antigen polysaccharide.
Biophysical journal 1996;71(4):2040-8.
1996: Steinbacher S; Baxa U; Miller S; Weintraub A; Seckler R; Huber R
Crystal structure of phage P22 tailspike protein complexed with Salmonella sp. O-antigen receptors.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(20):10584-8.
1996: Engh R A; Girod A; Kinzel V; Huber R; Bossemeyer D
Crystal structures of catalytic subunit of cAMP-dependent protein kinase in complex with isoquinolinesulfonyl protein kinase inhibitors H7, H8, and H89. Structural implications for selectivity.
The Journal of biological chemistry 1996;271(42):26157-64.
1996: Clausen T; Huber R; Laber B; Pohlenz H D; Messerschmidt A
Crystal structure of the pyridoxal-5'-phosphate dependent cystathionine beta-lyase from Escherichia coli at 1.83 A.
Journal of molecular biology 1996;262(2):202-24.
1996: Huber R; Hof P; Duarte R O; Moura J J; Moura I; Liu M Y; LeGall J; Hille R; Archer M; Romão M J
A structure-based catalytic mechanism for the xanthine oxidase family of molybdenum enzymes.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(17):8846-51.
1996: Stock D; Nederlof P M; Seemüller E; Baumeister W; Huber R; Löwe J
Proteasome: from structure to function.
Current opinion in biotechnology 1996;7(4):376-85.
1996: Benz J; Bergner A; Hofmann A; Demange P; Göttig P; Liemann S; Huber R; Voges D
The structure of recombinant human annexin VI in crystals and membrane-bound.
Journal of molecular biology 1996;260(5):638-43.
1996: Machius M; Vértesy L; Huber R; Wiegand G
Carbohydrate and protein-based inhibitors of porcine pancreatic alpha-amylase: structure analysis and comparison of their binding characteristics.
Journal of molecular biology 1996;260(3):409-21.
1996: Stubbs M T; Nar H; Löwe J; Huber R; Ladenstein R; Spangfort M D; Svensson L A
Locating a local symmetry axis from patterson map cross vectors: application to crystal data from GroEl, GTP cyclohydrolase I and the proteosome.
Acta crystallographica. Section D, Biological crystallography 1996;52(Pt 3):447-52.
1996: Liemann S; Benz J; Burger A; Voges D; Hofmann A; Huber R; Göttig P
Structural and functional characterisation of the voltage sensor in the ion channel human annexin V.
Journal of molecular biology 1996;258(4):555-61.
1996: Baumgartner R; Czisch M; Mayer U; Pöschl E; Huber R; Timpl R; Holak T A
Structure of the nidogen binding LE module of the laminin gamma1 chain in solution.
Journal of molecular biology 1996;257(3):658-68.
1996: Stetefeld J; Mayer U; Timpl R; Huber R
Crystal structure of three consecutive laminin-type epidermal growth factor-like (LE) modules of laminin gamma1 chain harboring the nidogen binding site.
Journal of molecular biology 1996;257(3):644-57.
1996: Burger A; Berendes R; Liemann S; Benz J; Hofmann A; Göttig P; Huber R; Gerke V; Thiel C; Römisch J; Weber K
The crystal structure and ion channel activity of human annexin II, a peripheral membrane protein.
Journal of molecular biology 1996;257(4):839-47.
1996: Lamba D; Bauer M; Huber R; Fischer S; Rudolph R; Kohnert U; Bode W
The 2.3 A crystal structure of the catalytic domain of recombinant two-chain human tissue-type plasminogen activator.
Journal of molecular biology 1996;258(1):117-35.
1996: Bacher A; Fischer M; Kis K; Kugelbrey K; Mörtl S; Scheuring J; Weinkauf S; Eberhardt S; Schmidt-Bäse K; Huber R; Ritsert K; Cushman M; Ladenstein R
Biosynthesis of riboflavin: structure and mechanism of lumazine synthase.
Biochemical Society transactions 1996;24(1):89-94.
1996: Nar H; Huber R; Meining W; Bracher A; Fischer M; Hösl C; Ritz H; Schmid C; Weinkauf S; Bacher A
Structure and mechanism of GTP cyclohydrolase I of Escherichia coli.
Biochemical Society transactions 1996;24(1):37S.
1996: Hammann C; Messerschmidt A; Huber R; Nar H; Gilardi G; Canters G W
X-ray crystal structure of the two site-specific mutants Ile7Ser and Phe110Ser of azurin from Pseudomonas aeruginosa.
Journal of molecular biology 1996;255(3):362-6.
1996: Bozic D; Grazulis S; Siksnys V; Huber R
Crystal structure of Citrobacter freundii restriction endonuclease Cfr10I at 2.15 A resolution.
Journal of molecular biology 1996;255(1):176-86.
1996: Laber B; Clausen T; Huber R; Messerschmidt A; Egner U; Müller-Fahrnow A; Pohlenz H D
Cloning, purification, and crystallization of Escherichia coli cystathionine beta-lyase.
FEBS letters 1996;379(1):94-6.
1996: Reinemer P; Prade L; Hof P; Neuefeind T; Huber R; Zettl R; Palme K; Schell J; Koelln I; Bartunik H D; Bieseler B
Three-dimensional structure of glutathione S-transferase from Arabidopsis thaliana at 2.2 A resolution: structural characterization of herbicide-conjugating plant glutathione S-transferases and a novel active site architecture.
Journal of molecular biology 1996;255(2):289-309.
1995: Nar H; Huber R; Auerbach G; Fischer M; Hösl C; Ritz H; Bracher A; Meining W; Eberhardt S; Bacher A
Active site topology and reaction mechanism of GTP cyclohydrolase I.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(26):12120-5.
1995: Engh R A; Huber R; Bode W; Schulze A J
Divining the serpin inhibition mechanism: a suicide substrate 'springe'?
Trends in biotechnology 1995;13(12):503-10.
1995: Oppliger T; Thöny B; Nar H; Bürgisser D; Huber R; Heizmann C W; Blau N
Structural and functional consequences of mutations in 6-pyruvoyltetrahydropterin synthase causing hyperphenylalaninemia in humans. Phosphorylation is a requirement for in vivo activity.
The Journal of biological chemistry 1995;270(49):29498-506.
1995: Romão M J; Archer M; Moura I; Moura J J; LeGall J; Engh R; Schneider M; Hof P; Huber R
Crystal structure of the xanthine oxidase-related aldehyde oxido-reductase from D. gigas.
Science (New York, N.Y.) 1995;270(5239):1170-6.
1995: Stubbs M T; Huber R; Bode W
Crystal structures of factor Xa specific inhibitors in complex with trypsin: structural grounds for inhibition of factor Xa and selectivity against thrombin.
FEBS letters 1995;375(1-2):103-7.
1995: van de Locht A; Lamba D; Bauer M; Huber R; Friedrich T; Kröger B; Höffken W; Bode W
Two heads are better than one: crystal structure of the insect derived double domain Kazal inhibitor rhodniin in complex with thrombin.
The EMBO journal 1995;14(21):5149-57.
1995: Brandstetter H; Bauer M; Huber R; Lollar P; Bode W
X-ray structure of clotting factor IXa: active site and module structure related to Xase activity and hemophilia B.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(21):9796-800.
1995: Bürgisser D M; Thöny B; Redweik U; Hess D; Heizmann C W; Huber R; Nar H
6-Pyruvoyl tetrahydropterin synthase, an enzyme with a novel type of active site involving both zinc binding and an intersubunit catalytic triad motif; site-directed mutagenesis of the proposed active center, characterization of the metal binding site and modelling of substrate binding.
Journal of molecular biology 1995;253(2):358-69.
1995: Meining W; Bacher A; Bachmann L; Schmid C; Weinkauf S; Huber R; Nar H
Elucidation of crystal packing by X-ray diffraction and freeze-etching electron microscopy. Studies on GTP cyclohydrolase I of Escherichia coli.
Journal of molecular biology 1995;253(1):208-18.
1995: Ritsert K; Huber R; Turk D; Ladenstein R; Schmidt-Bäse K; Bacher A
Studies on the lumazine synthase/riboflavin synthase complex of Bacillus subtilis: crystal structure analysis of reconstituted, icosahedral beta-subunit capsids with bound substrate analogue inhibitor at 2.4 A resolution.
Journal of molecular biology 1995;253(1):151-67.
1995: Archer M; Huber R; Tavares P; Moura I; Moura J J; Carrondo M A; Sieker L C; LeGall J; Romão M J
Crystal structure of desulforedoxin from Desulfovibrio gigas determined at 1.8 A resolution: a novel non-heme iron protein structure.
Journal of molecular biology 1995;251(5):690-702.
1995: Gomis-Rüth F X; Gómez M; Bode W; Huber R; Avilés F X
The three-dimensional structure of the native ternary complex of bovine pancreatic procarboxypeptidase A with proproteinase E and chymotrypsinogen C.
The EMBO journal 1995;14(18):4387-94.
1995: Huber R; Kohl B; Sachs G; Senn-Bilfinger J; Simon W A; Sturm E
Review article: the continuing development of proton pump inhibitors with particular reference to pantoprazole.
Alimentary pharmacology & therapeutics 1995;9(4):363-78.
1995: Soulimane T; Gohlke U; Huber R; Buse G
Three-dimensional crystals of cytochrome-c oxidase from Thermus thermophilus diffracting to 3.8 A resolution.
FEBS letters 1995;368(1):132-4.
1995: Strobl S; Mühlhahn P; Bernstein R; Wiltscheck R; Maskos K; Wunderlich M; Huber R; Glockshuber R; Holak T A
Determination of the three-dimensional structure of the bifunctional alpha-amylase/trypsin inhibitor from ragi seeds by NMR spectroscopy.
Biochemistry 1995;34(26):8281-93.
1995: Brejc K; Ficner R; Huber R; Steinbacher S
Isolation, crystallization, crystal structure analysis and refinement of allophycocyanin from the cyanobacterium Spirulina platensis at 2.3 A resolution.
Journal of molecular biology 1995;249(2):424-40.
1995: Budisa N; Steipe B; Demange P; Eckerskorn C; Kellermann J; Huber R
High-level biosynthetic substitution of methionine in proteins by its analogs 2-aminohexanoic acid, selenomethionine, telluromethionine and ethionine in Escherichia coli.
European journal of biochemistry / FEBS 1995;230(2):788-96.
1995: Beissinger M; Lee S C; Steinbacher S; Reinemer P; Huber R; Yu M H; Seckler R
Mutations that stabilize folding intermediates of phage P22 tailspike protein: folding in vivo and in vitro, stability, and structural context.
Journal of molecular biology 1995;249(1):185-94.
1995: Nar H; Huber R; Meining W; Schmid C; Weinkauf S; Bacher A
Atomic structure of GTP cyclohydrolase I.
Structure (London, England : 1993) 1995;3(5):459-66.
1995: Seemüller E; Lupas A; Stock D; Löwe J; Huber R; Baumeister W
Proteasome from Thermoplasma acidophilum: a threonine protease.
Science (New York, N.Y.) 1995;268(5210):579-82.
1995: Löwe J; Stock D; Jap B; Zwickl P; Baumeister W; Huber R
Crystal structure of the 20S proteasome from the archaeon T. acidophilum at 3.4 A resolution.
Science (New York, N.Y.) 1995;268(5210):533-9.
1995: Turk D; Podobnik M; Popovic T; Katunuma N; Bode W; Huber R; Turk V
Crystal structure of cathepsin B inhibited with CA030 at 2.0-A resolution: A basis for the design of specific epoxysuccinyl inhibitors.
Biochemistry 1995;34(14):4791-7.
1995: Wiegand G; Epp O; Huber R
The crystal structure of porcine pancreatic alpha-amylase in complex with the microbial inhibitor Tendamistat.
Journal of molecular biology 1995;247(1):99-110.
1995: Machius M; Wiegand G; Huber R
Crystal structure of calcium-depleted Bacillus licheniformis alpha-amylase at 2.2 A resolution.
Journal of molecular biology 1995;246(4):545-59.
1995: Korndörfer I; Steipe B; Huber R; Tomschy A; Jaenicke R
The crystal structure of holo-glyceraldehyde-3-phosphate dehydrogenase from the hyperthermophilic bacterium Thermotoga maritima at 2.5 A resolution.
Journal of molecular biology 1995;246(4):511-21.
1995: Grams F; Reinemer P; Powers J C; Kleine T; Pieper M; Tschesche H; Huber R; Bode W
X-ray structures of human neutrophil collagenase complexed with peptide hydroxamate and peptide thiol inhibitors. Implications for substrate binding and rational drug design.
European journal of biochemistry / FEBS 1995;228(3):830-41.
1995: Mirwaldt C; Korndörfer I; Huber R
The crystal structure of dihydrodipicolinate synthase from Escherichia coli at 2.5 A resolution.
Journal of molecular biology 1995;246(1):227-39.
1995: Stock D; Ditzel L; Baumeister W; Huber R; Löwe J
Catalytic mechanism of the 20S proteasome of Thermoplasma acidophilum revealed by X-ray crystallography.
Cold Spring Harbor symposia on quantitative biology 1995;60():525-32.
1995: Voges D; Berendes R; Demange P; Benz J; Göttig P; Liemann S; Huber R; Burger A
Structure and function of the ion channel model system annexin V.
Advances in enzymology and related areas of molecular biology 1995;71():209-39.
1995: Reinemer P; Dirr H W; Huber R
X-ray structure methods for glutathione binding.
Methods in enzymology 1995;251():243-54.
1994: Dirr H; Reinemer P; Huber R
Refined crystal structure of porcine class Pi glutathione S-transferase (pGST P1-1) at 2.1 A resolution.
Journal of molecular biology 1994;243(1):72-92.
1994: Hoppe E; Berne P F; Stock D; Rasmussen J S; Møller N P; Ullrich A; Huber R
Expression, purification and crystallization of human phosphotyrosine phosphatase 1B.
European journal of biochemistry / FEBS 1994;223(3):1069-77.
1994: Ladenstein R; Ritsert K; Huber R; Richter G; Bacher A
The lumazine synthase/riboflavin synthase complex of Bacillus subtilis. X-ray structure analysis of hollow reconstituted beta-subunit capsids.
European journal of biochemistry / FEBS 1994;223(3):1007-17.
1994: Schiffer C A; Huber R; Wüthrich K; van Gunsteren W F
Simultaneous refinement of the structure of BPTI against NMR data measured in solution and X-ray diffraction data measured in single crystals.
Journal of molecular biology 1994;241(4):588-99.
1994: Steinbacher S; Seckler R; Miller S; Steipe B; Huber R; Reinemer P
Crystal structure of P22 tailspike protein: interdigitated subunits in a thermostable trimer.
Science (New York, N.Y.) 1994;265(5170):383-6.
1994: Demange P; Voges D; Benz J; Liemann S; Göttig P; Berendes R; Burger A; Huber R
Annexin V: the key to understanding ion selectivity and voltage regulation?
Trends in biochemical sciences 1994;19(7):272-6.
1994: Kungl A J; Machius M; Huber R; Schwer C; Lam C; Aschauer H; Ehn G; Lindley I J; Auer M
Purification, crystallization and preliminary X-ray diffraction analysis of recombinant human neutrophil-activating peptide 2 (rhNAP-2).
FEBS letters 1994;347(2-3):300-3.
1994: Gomis-Rüth F X; Kress L F; Kellermann J; Mayr I; Lee X; Huber R; Bode W
Refined 2.0 A X-ray crystal structure of the snake venom zinc-endopeptidase adamalysin II. Primary and tertiary structure determination, refinement, molecular structure and comparison with astacin, collagenase and thermolysin.
Journal of molecular biology 1994;239(4):513-44.
1994: Schulze A J; Huber R; Bode W; Engh R A
Structural aspects of serpin inhibition.
FEBS letters 1994;344(2-3):117-24.
1994: Voges D; Berendes R; Burger A; Demange P; Baumeister W; Huber R
Three-dimensional structure of membrane-bound annexin V. A correlative electron microscopy-X-ray crystallography study.
Journal of molecular biology 1994;238(2):199-213.
1994: Burger A; Voges D; Demange P; Perez C R; Huber R; Berendes R
Structural and electrophysiological analysis of annexin V mutants. Mutagenesis of human annexin V, an in vitro voltage-gated calcium channel, provides information about the structural features of the ion pathway, the voltage sensor and the ion selectivity filter.
Journal of molecular biology 1994;237(4):479-99.
1994: Bazan J F; Weaver L H; Roderick S L; Huber R; Matthews B W
Sequence and structure comparison suggest that methionine aminopeptidase, prolidase, aminopeptidase P, and creatinase share a common fold.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(7):2473-7.
1994: Thoenes U; Flores O L; Neves A; Devreese B; Van Beeumen J J; Huber R; Romão M J; LeGall J; Moura J J; Rodrigues-Pousada C
Molecular cloning and sequence analysis of the gene of the molybdenum-containing aldehyde oxido-reductase of Desulfovibrio gigas. The deduced amino acid sequence shows similarity to xanthine dehydrogenase.
European journal of biochemistry / FEBS 1994;220(3):901-10.
1994: Dirr H; Reinemer P; Huber R
X-ray crystal structures of cytosolic glutathione S-transferases. Implications for protein architecture, substrate recognition and catalytic function.
European journal of biochemistry / FEBS 1994;220(3):645-61.
1994: Bode W; Reinemer P; Huber R; Kleine T; Schnierer S; Tschesche H
The X-ray crystal structure of the catalytic domain of human neutrophil collagenase inhibited by a substrate analogue reveals the essentials for catalysis and specificity.
The EMBO journal 1994;13(6):1263-9.
1994: Nar H; Huber R; Heizmann C W; Thöny B; Bürgisser D
Three-dimensional structure of 6-pyruvoyl tetrahydropterin synthase, an enzyme involved in tetrahydrobiopterin biosynthesis.
The EMBO journal 1994;13(6):1255-62.
1994: Romero A; Nar H; Huber R; Messerschmidt A; Kalverda A P; Canters G W; Durley R; Mathews F S
Crystal structure analysis and refinement at 2.15 A resolution of amicyanin, a type I blue copper protein, from Thiobacillus versutus.
Journal of molecular biology 1994;236(4):1196-211.
1994: Humm A; Huber R; Mann K
The amino acid sequences of human and pig L-arginine:glycine amidinotransferase.
FEBS letters 1994;339(1-2):101-7.
1994: Schulze A J; Degryse E; Speck D; Huber R; Bischoff R
Expression of alpha 1-proteinase inhibitor in Escherichia coli: effects of single amino acid substitutions in the active site loop on aggregate formation.
Journal of biotechnology 1994;32(3):231-8.
1994: Reinemer P; Grams F; Huber R; Kleine T; Schnierer S; Piper M; Tschesche H; Bode W
Structural implications for the role of the N terminus in the 'superactivation' of collagenases. A crystallographic study.
FEBS letters 1994;338(2):227-33.
1993: Engh R A; Dieckmann T; Bode W; Auerswald E A; Turk V; Huber R; Oschkinat H
Conformational variability of chicken cystatin. Comparison of structures determined by X-ray diffraction and NMR spectroscopy.
Journal of molecular biology 1993;234(4):1060-9.
1993: Jap B; Pühler G; Lücke H; Typke D; Löwe J; Stock D; Huber R; Baumeister W
Preliminary X-ray crystallographic study of the proteasome from Thermoplasma acidophilum.
Journal of molecular biology 1993;234(3):881-4.
1993: Engh R A; Schulze A J; Huber R; Bode W
Serpin structures.
Behring Institute Mitteilungen 1993;(93):41-62.
1993: Grams F; Huber R; Kress L F; Moroder L; Bode W
Activation of snake venom metalloproteinases by a cysteine switch-like mechanism.
FEBS letters 1993;335(1):76-80.
1993: Ficner R; Huber R
Refined crystal structure of phycoerythrin from Porphyridium cruentum at 0.23-nm resolution and localization of the gamma subunit.
European journal of biochemistry / FEBS 1993;218(1):103-6.
1993: Berendes R; Voges D; Demange P; Huber R; Burger A
Structure-function analysis of the ion channel selectivity filter in human annexin V.
Science (New York, N.Y.) 1993;262(5132):427-30.
1993: Padmanabhan K; Padmanabhan K P; Tulinsky A; Park C H; Bode W; Huber R; Blankenship D T; Cardin A D; Kisiel W
Structure of human des(1-45) factor Xa at 2.2 A resolution.
Journal of molecular biology 1993;232(3):947-66.
1993: Burger A; Berendes R; Voges D; Huber R; Demange P
A rapid and efficient purification method for recombinant annexin V for biophysical studies.
FEBS letters 1993;329(1-2):25-8.
1993: Romão M J; Barata B A; Archer M; Lobeck K; Moura I; Carrondo M A; LeGall J; Lottspeich F; Huber R; Moura J J
Subunit composition, crystallization and preliminary crystallographic studies of the Desulfovibrio gigas aldehyde oxidoreductase containing molybdenum and [2Fe-2S] centers.
European journal of biochemistry / FEBS 1993;215(3):729-32.
1993: Karshikoff A; Reinemer P; Huber R; Ladenstein R
Electrostatic evidence for the activation of the glutathione thiol by Tyr7 in pi-class glutathione transferases.
European journal of biochemistry / FEBS 1993;215(3):663-70.
1993: Xia C; Meyer D J; Chen H; Reinemer P; Huber R; Ketterer B
Chemical modification of GSH transferase P1-1 confirms the presence of Arg-13, Lys-44 and one carboxylate group in the GSH-binding domain of the active site.
The Biochemical journal 1993;293 ( Pt 2)():357-62.
1993: Sinning I; Kleywegt G J; Cowan S W; Reinemer P; Dirr H W; Huber R; Gilliland G L; Armstrong R N; Ji X; Board P G
Structure determination and refinement of human alpha class glutathione transferase A1-1, and a comparison with the Mu and Pi class enzymes.
Journal of molecular biology 1993;232(1):192-212.
1993: Messerschmidt A; Luecke H; Huber R
X-ray structures and mechanistic implications of three functional derivatives of ascorbate oxidase from zucchini. Reduced, peroxide and azide forms.
Journal of molecular biology 1993;230(3):997-1014.
1993: Bewley M C; Boustead C M; Walker J H; Waller D A; Huber R
Structure of chicken annexin V at 2.25-A resolution.
Biochemistry 1993;32(15):3923-9.
1993: Weng X; Luecke H; Song I S; Kang D S; Kim S H; Huber R
Crystal structure of human annexin I at 2.5 A resolution.
Protein science : a publication of the Protein Society 1993;2(3):448-58.
1993: Lin G; Bode W; Huber R; Chi C; Engh R A
The 0.25-nm X-ray structure of the Bowman-Birk-type inhibitor from mung bean in ternary complex with porcine trypsin.
European journal of biochemistry / FEBS 1993;212(2):549-55.
1993: Bossemeyer D; Engh R A; Kinzel V; Ponstingl H; Huber R
Phosphotransferase and substrate binding mechanism of the cAMP-dependent protein kinase catalytic subunit from porcine heart as deduced from the 2.0 A structure of the complex with Mn2+ adenylyl imidodiphosphate and inhibitor peptide PKI(5-24).
The EMBO journal 1993;12(3):849-59.
1993: Gomis-Rüth F X; Stöcker W; Huber R; Zwilling R; Bode W
Refined 1.8 A X-ray crystal structure of astacin, a zinc-endopeptidase from the crayfish Astacus astacus L. Structure determination, refinement, molecular structure and comparison with thermolysin.
Journal of molecular biology 1993;229(4):945-68.
1993: Avilés F X; Vendrell J; Guasch A; Coll M; Huber R
Advances in metallo-procarboxypeptidases. Emerging details on the inhibition mechanism and on the activation process.
European journal of biochemistry / FEBS 1993;211(3):381-9.
1993: Romero A; Hoitink C W; Nar H; Huber R; Messerschmidt A; Canters G W
X-ray analysis and spectroscopic characterization of M121Q azurin. A copper site model for stellacyanin.
Journal of molecular biology 1993;229(4):1007-21.
1993: Berendes R; Burger A; Voges D; Demange P; Huber R
Calcium influx through annexin V ion channels into large unilamellar vesicles measured with fura-2.
FEBS letters 1993;317(1-2):131-4.
1992: Szyperski T; Güntert P; Stone S R; Tulinsky A; Bode W; Huber R; Wüthrich K
Impact of protein-protein contacts on the conformation of thrombin-bound hirudin studied by comparison with the nuclear magnetic resonance solution structure of hirudin(1-51).
Journal of molecular biology 1992;228(4):1206-11.
1992: Ficner R; Lobeck K; Schmidt G; Huber R
Isolation, crystallization, crystal structure analysis and refinement of B-phycoerythrin from the red alga Porphyridium sordidum at 2.2 A resolution.
Journal of molecular biology 1992;228(3):935-50.
1992: Laber B; Gomis-Rüth F X; Romão M J; Huber R
Escherichia coli dihydrodipicolinate synthase. Identification of the active site and crystallization.
The Biochemical journal 1992;288 ( Pt 2)():691-5.
1992: Lewit-Bentley A; Morera S; Huber R; Bodo G
The effect of metal binding on the structure of annexin V and implications for membrane binding.
European journal of biochemistry / FEBS 1992;210(1):73-7.
1992: van de Kamp M; Canters G W; Wijmenga S S; Lommen A; Hilbers C W; Nar H; Messerschmidt A; Huber R
Complete sequential 1H and 15N nuclear magnetic resonance assignments and solution secondary structure of the blue copper protein azurin from Pseudomonas aeruginosa.
Biochemistry 1992;31(42):10194-207.
1992: Messerschmidt A; Steigemann W; Huber R; Lang G; Kroneck P M
X-ray crystallographic characterisation of type-2-depleted ascorbate oxidase from zucchini.
European journal of biochemistry / FEBS 1992;209(2):597-602.
1992: Reinemer P; Dirr H W; Ladenstein R; Huber R; Lo Bello M; Federici G; Parker M W
Three-dimensional structure of class pi glutathione S-transferase from human placenta in complex with S-hexylglutathione at 2.8 A resolution.
Journal of molecular biology 1992;227(1):214-26.
1992: Schmid C; Ladenstein R; Luecke H; Huber R; Bacher A
Crystallization and preliminary crystallographic characterization of GTP cyclohydrolase I from Escherichia coli.
Journal of molecular biology 1992;226(4):1279-81.
1992: Baumann U; Bode W; Huber R; Travis J; Potempa J
Crystal structure of cleaved equine leucocyte elastase inhibitor determined at 1.95 A resolution.
Journal of molecular biology 1992;226(4):1207-18.
1992: Schulze A J; Frohnert P W; Engh R A; Huber R
Evidence for the extent of insertion of the active site loop of intact alpha 1 proteinase inhibitor in beta-sheet A.
Biochemistry 1992;31(33):7560-5.
1992: Romão M J; Turk D; Gomis-Rüth F X; Huber R; Schumacher G; Möllering H; Rüssmann L
Crystal structure analysis, refinement and enzymatic reaction mechanism of N-carbamoylsarcosine amidohydrolase from Arthrobacter sp. at 2.0 A resolution.
Journal of molecular biology 1992;226(4):1111-30.
1992: Manoharan T H; Gulick A M; Reinemer P; Dirr H W; Huber R; Fahl W E
Mutational substitution of residues implicated by crystal structure in binding the substrate glutathione to human glutathione S-transferase pi.
Journal of molecular biology 1992;226(2):319-22.
1992: Nar H; Messerschmidt A; Huber R; van de Kamp M; Canters G W
Crystal structure of Pseudomonas aeruginosa apo-azurin at 1.85 A resolution.
FEBS letters 1992;306(2-3):119-24.
1992: Vendrell J; Guasch A; Coll M; Villegas V; Billeter M; Wider G; Huber R; Wüthrich K; Avilés F X
Pancreatic procarboxypeptidases: their activation processes related to the structural features of the zymogens and activation segments.
Biological chemistry Hoppe-Seyler 1992;373(7):387-92.
1992: Bode W; Gomis-Rüth F X; Huber R; Zwilling R; Stöcker W
Structure of astacin and implications for activation of astacins and zinc-ligation of collagenases.
Nature 1992;358(6382):164-7.
1992: Bacher A; Weinkauf S; Bachmann L; Ritsert K; Baumeister W; Huber R; Ladenstein R
Electron microscopy of decorated crystals for the determination of crystallographic rotation and translation parameters in large protein complexes.
Journal of molecular biology 1992;225(4):1065-73.
1992: Steipe B; Plückthun A; Huber R
Refined crystal structure of a recombinant immunoglobulin domain and a complementarity-determining region 1-grafted mutant.
Journal of molecular biology 1992;225(3):739-53.
1992: Stubbs M T; Oschkinat H; Mayr I; Huber R; Angliker H; Stone S R; Bode W
The interaction of thrombin with fibrinogen. A structural basis for its specificity.
European journal of biochemistry / FEBS 1992;206(1):187-95.
1992: Nar H; Huber R; Messerschmidt A; Filippou A C; Barth M; Jaquinod M; van de Kamp M; Canters G W
Characterization and crystal structure of zinc azurin, a by-product of heterologous expression in Escherichia coli of Pseudomonas aeruginosa copper azurin.
European journal of biochemistry / FEBS 1992;205(3):1123-9.
1992: Martin P D; Robertson W; Turk D; Huber R; Bode W; Edwards B F
The structure of residues 7-16 of the A alpha-chain of human fibrinogen bound to bovine thrombin at 2.3-A resolution.
The Journal of biological chemistry 1992;267(11):7911-20.
1992: Huber R; Berendes R; Burger A; Luecke H; Karshikov A
Annexin V-crystal structure and its implications on function.
Behring Institute Mitteilungen 1992;(91):107-25.
1992: Messerschmidt A; Ladenstein R; Huber R; Bolognesi M; Avigliano L; Petruzzelli R; Rossi A; Finazzi-Agró A
Refined crystal structure of ascorbate oxidase at 1.9 A resolution.
Journal of molecular biology 1992;224(1):179-205.
1992: Guasch A; Coll M; Avilés F X; Huber R
Three-dimensional structure of porcine pancreatic procarboxypeptidase A. A comparison of the A and B zymogens and their determinants for inhibition and activation.
Journal of molecular biology 1992;224(1):141-57.
1992: Bode W; Huber R
Natural protein proteinase inhibitors and their interaction with proteinases.
European journal of biochemistry / FEBS 1992;204(2):433-51.
1992: Huber R; Berendes R; Burger A; Schneider M; Karshikov A; Luecke H; Römisch J; Paques E
Crystal and molecular structure of human annexin V after refinement. Implications for structure, membrane binding and ion channel formation of the annexin family of proteins.
Journal of molecular biology 1992;223(3):683-704.
1992: Billeter M; Vendrell J; Wider G; Aviles F X; Coll M; Guasch A; Huber R; Wuthrich K
Comparison of the NMR solution structure with the X-ray crystal structure of the activation domain from procarboxypeptidase B.
Journal of biomolecular NMR 1992;2(1):1-10.
1991: Schulze A J; Huber R; Degryse E; Speck D; Bischoff R
Inhibitory activity and conformational transition of alpha 1-proteinase inhibitor variants.
European journal of biochemistry / FEBS 1991;202(3):1147-55.
1991: Nar H; Messerschmidt A; Huber R; van de Kamp M; Canters G W
Crystal structure analysis of oxidized Pseudomonas aeruginosa azurin at pH 5.5 and pH 9.0. A pH-induced conformational transition involves a peptide bond flip.
Journal of molecular biology 1991;221(3):765-72.
1991: Weinkauf S; Bacher A; Baumeister W; Ladenstein R; Huber R; Bachmann L
Correlation of metal decoration and topochemistry on protein surfaces.
Journal of molecular biology 1991;221(2):637-45.
1991: Rydel T J; Tulinsky A; Bode W; Huber R
Refined structure of the hirudin-thrombin complex.
Journal of molecular biology 1991;221(2):583-601.
1991: Musil D; Zucic D; Turk D; Engh R A; Mayr I; Huber R; Popovic T; Turk V; Towatari T; Katunuma N
The refined 2.15 A X-ray crystal structure of human liver cathepsin B: the structural basis for its specificity.
The EMBO journal 1991;10(9):2321-30.
1991: Kessler H; Mronga S; Müller G; Moroder L; Huber R
Conformational analysis of a IgG1 hinge peptide derivative in solution determined by NMR spectroscopy and refined by restrained molecular dynamics simulations.
Biopolymers 1991;31(10):1189-204.
1991: Reinemer P; Dirr H W; Ladenstein R; Schäffer J; Gallay O; Huber R
The three-dimensional structure of class pi glutathione S-transferase in complex with glutathione sulfonate at 2.3 A resolution.
The EMBO journal 1991;10(8):1997-2005.
1991: Karshikov A; Duerring M; Huber R
Role of electrostatic interaction in the stability of the hexamer of constitutive phycocyanin from Fremyella diplosiphon.
Protein engineering 1991;4(6):681-90.
1991: Musil D; Bode W; Huber R; Laskowski M; Lin T Y; Ardelt W
Refined X-ray crystal structures of the reactive site modified ovomucoid inhibitor third domains from silver pheasant (OMSVP3*) and from Japanese quail (OMJPQ3*).
Journal of molecular biology 1991;220(3):739-55.
1991: Mann K; Schlenkrich T; Bauer M; Huber R
The amino-acid sequence of three proteins of photosystem I of the cyanobacterium Fremyella diplosiphon (Calothrix sp PCC 7601).
Biological chemistry Hoppe-Seyler 1991;372(7):519-24.
1991: Brisson A; Mosser G; Huber R
Structure of soluble and membrane-bound human annexin V.
Journal of molecular biology 1991;220(2):199-203.
1991: Baumann U; Huber R; Bode W; Grosse D; Lesjak M; Laurell C B
Crystal structure of cleaved human alpha 1-antichymotrypsin at 2.7 A resolution and its comparison with other serpins.
Journal of molecular biology 1991;218(3):595-606.
1991: Dirr H W; Mann K; Huber R; Ladenstein R; Reinemer P
Class pi glutathione S-transferase from pig lung. Purification, biochemical characterization, primary structure and crystallization.
European journal of biochemistry / FEBS 1991;196(3):693-8.
1991: Nar H; Messerschmidt A; Huber R; van de Kamp M; Canters G W
X-ray crystal structure of the two site-specific mutants His35Gln and His35Leu of azurin from Pseudomonas aeruginosa.
Journal of molecular biology 1991;218(2):427-47.
1991: Phipps B M; Huber R; Baumeister W
The cell envelope of the hyperthermophilic archaebacterium Pyrobaculum organotrphum consists of two regularly arrayed protein layers: three-dimensional structure of the outer layer.
Molecular microbiology 1991;5(2):253-65.
1991: Duerring M; Schmidt G B; Huber R
Isolation, crystallization, crystal structure analysis and refinement of constitutive C-phycocyanin from the chromatically adapting cyanobacterium Fremyella diplosiphon at 1.66 A resolution.
Journal of molecular biology 1991;217(3):577-92.
1991: Coll M; Guasch A; Avilés F X; Huber R
Three-dimensional structure of porcine procarboxypeptidase B: a structural basis of its inactivity.
The EMBO journal 1991;10(1):1-9.
1991: Bode W; Huber R
Proteinase-protein inhibitor interaction.
Biomedica biochimica acta 1991;50(4-6):437-46.
1990: Huber R; Römisch J; Paques E P
The crystal and molecular structure of human annexin V, an anticoagulant protein that binds to calcium and membranes.
The EMBO journal 1990;9(12):3867-74.
1990: Schulze A J; Baumann U; Knof S; Jaeger E; Huber R; Laurell C B
Structural transition of alpha 1-antitrypsin by a peptide sequentially similar to beta-strand s4A.
European journal of biochemistry / FEBS 1990;194(1):51-6.
1990: Huber R; Schneider M; Mayr I; Römisch J; Paques E P
The calcium binding sites in human annexin V by crystal structure analysis at 2.0 A resolution. Implications for membrane binding and calcium channel activity.
FEBS letters 1990;275(1-2):15-21.
1990: Rydel T J; Ravichandran K G; Tulinsky A; Bode W; Huber R; Roitsch C; Fenton J W
The structure of a complex of recombinant hirudin and human alpha-thrombin.
Science (New York, N.Y.) 1990;249(4966):277-80.
1990: Coll M; Knof S H; Ohga Y; Messerschmidt A; Huber R; Moellering H; Rüssmann L; Schumacher G
Enzymatic mechanism of creatine amidinohydrolase as deduced from crystal structures.
Journal of molecular biology 1990;214(2):597-610.
1990: Wright H T; Qian H X; Huber R
Crystal structure of plakalbumin, a proteolytically nicked form of ovalbumin. Its relationship to the structure of cleaved alpha-1-proteinase inhibitor.
Journal of molecular biology 1990;213(3):513-28.
1990: Stubbs M T; Laber B; Bode W; Huber R; Jerala R; Lenarcic B; Turk V
The refined 2.4 A X-ray crystal structure of recombinant human stefin B in complex with the cysteine proteinase papain: a novel type of proteinase inhibitor interaction.
The EMBO journal 1990;9(6):1939-47.
1990: Glockshuber R; Steipe B; Huber R; Plückthun A
Crystallization and preliminary X-ray studies of the VL domain of the antibody McPC603 produced in Escherichia coli.
Journal of molecular biology 1990;213(4):613-5.
1990: Engh R A; Wright H T; Huber R
Modeling the intact form of the alpha 1-proteinase inhibitor.
Protein engineering 1990;3(6):469-77.
1990: Bode W; Engh R; Musil D; Laber B; Stubbs M; Huber R; Turk V
Mechanism of interaction of cysteine proteinases and their protein inhibitors as compared to the serine proteinase-inhibitor interaction.
Biological chemistry Hoppe-Seyler 1990;371 Suppl():111-8.
1990: Stubbs M; Summers L; Mayr I; Schneider M; Bode W; Huber R; Ries A; Kühn K
Crystals of the NC1 domain of human type IV collagen.
Journal of molecular biology 1990;211(4):683-4.
1990: Duerring M; Huber R; Bode W; Ruembeli R; Zuber H
Refined three-dimensional structure of phycoerythrocyanin from the cyanobacterium Mastigocladus laminosus at 2.7 A.
Journal of molecular biology 1990;211(3):633-44.
1990: Messerschmidt A; Huber R
The blue oxidases, ascorbate oxidase, laccase and ceruloplasmin. Modelling and structural relationships.
European journal of biochemistry / FEBS 1990;187(2):341-52.
1990: Huber R
E. Antonini Plenary lecture. A structural basis of light energy and electron transfer in biology.
European journal of biochemistry / FEBS 1990;187(2):283-305.
1989: Huber R
Nobel lecture. A structural basis of light energy and electron transfer in biology.
Bioscience reports 1989;9(6):635-73.
1989: Holak T A; Bode W; Huber R; Otlewski J; Wilusz T
Nuclear magnetic resonance solution and X-ray structures of squash trypsin inhibitor exhibit the same conformation of the proteinase binding loop.
Journal of molecular biology 1989;210(3):649-54.
1989: Huber R; Carrell R W
Implications of the three-dimensional structure of alpha 1-antitrypsin for structure and function of serpins.
Biochemistry 1989;28(23):8951-66.
1989: Bode W; Mayr I; Baumann U; Huber R; Stone S R; Hofsteenge J
The refined 1.9 A crystal structure of human alpha-thrombin: interaction with D-Phe-Pro-Arg chloromethylketone and significance of the Tyr-Pro-Pro-Trp insertion segment.
The EMBO journal 1989;8(11):3467-75.
1989: Huber R
Nobel lecture. A structural basis of light energy and electron transfer in biology.
The EMBO journal 1989;8(8):2125-47.
1989: Laber B; Krieglstein K; Henschen A; Kos J; Turk V; Huber R; Bode W
The cysteine proteinase inhibitor chicken cystatin is a phosphoprotein.
FEBS letters 1989;248(1-2):162-8.
1989: Billeter M; Kline A D; Braun W; Huber R; Wüthrich K
Comparison of the high-resolution structures of the alpha-amylase inhibitor tendamistat determined by nuclear magnetic resonance in solution and by X-ray diffraction in single crystals.
Journal of molecular biology 1989;206(4):677-87.
1989: Braun W; Epp O; Wüthrich K; Huber R
Solution of the phase problem in the X-ray diffraction method for proteins with the nuclear magnetic resonance solution structure as initial model. Patterson search and refinement for the alpha-amylase inhibitor tendamistat.
Journal of molecular biology 1989;206(4):669-76.
1989: Messerschmidt A; Rossi A; Ladenstein R; Huber R; Bolognesi M; Gatti G; Marchesini A; Petruzzelli R; Finazzi-Agró A
X-ray crystal structure of the blue oxidase ascorbate oxidase from zucchini. Analysis of the polypeptide fold and a model of the copper sites and ligands.
Journal of molecular biology 1989;206(3):513-29.
1989: Engh R; Löbermann H; Schneider M; Wiegand G; Huber R; Laurell C B
The S variant of human alpha 1-antitrypsin, structure and implications for function and metabolism.
Protein engineering 1989;2(6):407-15.
1989: Bode W; Greyling H J; Huber R; Otlewski J; Wilusz T
The refined 2.0 A X-ray crystal structure of the complex formed between bovine beta-trypsin and CMTI-I, a trypsin inhibitor from squash seeds (Cucurbita maxima). Topological similarity of the squash seed inhibitors with the carboxypeptidase A inhibitor from potatoes.
FEBS letters 1989;242(2):285-92.
1988: Hoeffken H W; Knof S H; Bartlett P A; Huber R; Moellering H; Schumacher G
Crystal structure determination, refinement and molecular model of creatine amidinohydrolase from Pseudomonas putida.
Journal of molecular biology 1988;204(2):417-33.
1988: Ladenstein R; Schneider M; Huber R; Bartunik H D; Wilson K; Schott K; Bacher A
Heavy riboflavin synthase from Bacillus subtilis. Crystal structure analysis of the icosahedral beta 60 capsid at 3.3 A resolution.
Journal of molecular biology 1988;203(4):1045-70.
1988: Bode W; Engh R; Musil D; Thiele U; Huber R; Karshikov A; Brzin J; Kos J; Turk V
The 2.0 A X-ray crystal structure of chicken egg white cystatin and its possible mode of interaction with cysteine proteinases.
The EMBO journal 1988;7(8):2593-9.
1988: Grütter M G; Fendrich G; Huber R; Bode W
The 2.5 A X-ray crystal structure of the acid-stable proteinase inhibitor from human mucous secretions analysed in its complex with bovine alpha-chymotrypsin.
The EMBO journal 1988;7(2):345-51.
1988: Messerschmidt A; Rossi A; Ladenstein R; Huber R; Bolognesi M; Marchesini A; Petruzelli R; Finazzi-Agro A
Preliminary X-ray crystal structure and partial cDNA-sequence of ascorbate oxidase from zucchini.
Progress in clinical and biological research 1988;274():285-8.
1987: Huber R
Flexibility and rigidity, requirements for the function of proteins and protein pigment complexes. Eleventh Keilin memorial lecture.
Biochemical Society transactions 1987;15(6):1009-20.
1987: Huber R; Schneider M; Mayr I; Müller R; Deutzmann R; Suter F; Zuber H; Falk H; Kayser H
Molecular structure of the bilin binding protein (BBP) from Pieris brassicae after refinement at 2.0 A resolution.
Journal of molecular biology 1987;198(3):499-513.
1987: Brünger A T; Huber R; Karplus M
Trypsinogen-trypsin transition: a molecular dynamics study of induced conformational change in the activation domain.
Biochemistry 1987;26(16):5153-62.
1987: Schirmer T; Bode W; Huber R
Refined three-dimensional structures of two cyanobacterial C-phycocyanins at 2.1 and 2.5 A resolution. A common principle of phycobilin-protein interaction.
Journal of molecular biology 1987;196(3):677-95.
1987: Ladenstein R; Bacher A; Huber R
Some observations of a correlation between the symmetry of large heavy-atom complexes and their binding sites on proteins.
Journal of molecular biology 1987;195(3):751-3.
1987: Huber R; Schneider M; Epp O; Mayr I; Messerschmidt A; Pflugrath J; Kayser H
Crystallization, crystal structure analysis and preliminary molecular model of the bilin binding protein from the insect Pieris brassicae.
Journal of molecular biology 1987;195(2):423-34.
1987: Huber R; Bennett W S
Antibody-antigen flexibility.
Nature 1987;326(6111):334-5.
1986: Allen J P; Feher G; Yeates T O; Rees D C; Deisenhofer J; Michel H; Huber R
Structural homology of reaction centers from Rhodopseudomonas sphaeroides and Rhodopseudomonas viridis as determined by x-ray diffraction.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(22):8589-93.
1986: Bode W; Wei A Z; Huber R; Meyer E; Travis J; Neumann S
X-ray crystal structure of the complex of human leukocyte elastase (PMN elastase) and the third domain of the turkey ovomucoid inhibitor.
The EMBO journal 1986;5(10):2453-8.
1986: Huber R
Structural basis for antigen-antibody recognition.
Science (New York, N.Y.) 1986;233(4765):702-3.
1986: Bock S C; Skriver K; Nielsen E; Thøgersen H C; Wiman B; Donaldson V H; Eddy R L; Marrinan J; Radziejewska E; Huber R
Human C1 inhibitor: primary structure, cDNA cloning, and chromosomal localization.
Biochemistry 1986;25(15):4292-301.
1986: Pflugrath J W; Wiegand G; Huber R; Vértesy L
Crystal structure determination, refinement and the molecular model of the alpha-amylase inhibitor Hoe-467A.
Journal of molecular biology 1986;189(2):383-6.
1986: Schirmer T; Huber R; Schneider M; Bode W; Miller M; Hackert M L
Crystal structure analysis and refinement at 2.5 A of hexameric C-phycocyanin from the cyanobacterium Agmenellum quadruplicatum. The molecular model and its implications for light-harvesting.
Journal of molecular biology 1986;188(4):651-76.
1986: Ladenstein R; Meyer B; Huber R; Labischinski H; Bartels K; Bartunik H D; Bachmann L; Ludwig H C; Bacher A
Heavy riboflavin synthase from Bacillus subtilis. Particle dimensions, crystal packing and molecular symmetry.
Journal of molecular biology 1986;187(1):87-100.
1985: Wang D; Bode W; Huber R
Bovine chymotrypsinogen A X-ray crystal structure analysis and refinement of a new crystal form at 1.8 A resolution.
Journal of molecular biology 1985;185(3):595-624.
1985: Schirmer T; Bode W; Huber R; Sidler W; Zuber H
X-ray crystallographic structure of the light-harvesting biliprotein C-phycocyanin from the thermophilic cyanobacterium Mastigocladus laminosus and its resemblance to globin structures.
Journal of molecular biology 1985;184(2):257-77.
1985: Bode W; Epp O; Huber R; Laskowski M; Ardelt W
The crystal and molecular structure of the third domain of silver pheasant ovomucoid (OMSVP3).
European journal of biochemistry / FEBS 1985;147(2):387-95.
1984: Deisenhofer J; Epp O; Miki K; Huber R; Michel H
X-ray structure analysis of a membrane protein complex. Electron density map at 3 A resolution and a model of the chromophores of the photosynthetic reaction center from Rhodopseudomonas viridis.
Journal of molecular biology 1984;180(2):385-98.
1984: Wlodawer A; Walter J; Huber R; Sjölin L
Structure of bovine pancreatic trypsin inhibitor. Results of joint neutron and X-ray refinement of crystal form II.
Journal of molecular biology 1984;180(2):301-29.
1984: Huber R
Three-dimensional structure of antibodies.
Behring Institute Mitteilungen 1984;(76):1-14.
1984: Bode W; Walter J; Huber R; Wenzel H R; Tschesche H
The refined 2.2-A (0.22-nm) X-ray crystal structure of the ternary complex formed by bovine trypsinogen, valine-valine and the Arg15 analogue of bovine pancreatic trypsin inhibitor.
European journal of biochemistry / FEBS 1984;144(1):185-90.
1984: Loebermann H; Tokuoka R; Deisenhofer J; Huber R
Human alpha 1-proteinase inhibitor. Crystal structure analysis of two crystal modifications, molecular model and preliminary analysis of the implications for function.
Journal of molecular biology 1984;177(3):531-57.
1984: Wiegand G; Remington S; Deisenhofer J; Huber R
Crystal structure analysis and molecular model of a complex of citrate synthase with oxaloacetate and S-acetonyl-coenzyme A.
Journal of molecular biology 1984;174(1):205-19.
1984: Bennett W S; Huber R
Structural and functional aspects of domain motions in proteins.
CRC critical reviews in biochemistry 1984;15(4):291-384.
1983: Walter J; Huber R
Pancreatic trypsin inhibitor. A new crystal form and its analysis.
Journal of molecular biology 1983;167(4):911-7.
1983: Huber R; Bennett W S
Functional significance of flexibility in proteins.
Biopolymers 1983;22(1):261-79.
1982: Bolognesi M; Gatti G; Menagatti E; Guarneri M; Marquart M; Papamokos E; Huber R
Three-dimensional structure of the complex between pancreatic secretory trypsin inhibitor (Kazal type) and trypsinogen at 1.8 A resolution. Structure solution, crystallographic refinement and preliminary structural interpretation.
Journal of molecular biology 1982;162(4):839-68.
1982: Löbermann H; Lottspeich F; Bode W; Huber R
Interaction of human alpha 1-proteinase inhibitor with chymotrypsinogen A and crystallization of a proteolytically modified alpha 1-proteinase inhibitor.
Hoppe-Seyler's Zeitschrift für physiologische Chemie 1982;363(11):1377-88.
1982: Papamokos E; Weber E; Bode W; Huber R; Empie M W; Kato I; Laskowski M
Crystallographic refinement of Japanese quail ovomucoid, a Kazal-type inhibitor, and model building studies of complexes with serine proteases.
Journal of molecular biology 1982;158(3):515-37.
1982: Remington S; Wiegand G; Huber R
Crystallographic refinement and atomic models of two different forms of citrate synthase at 2.7 and 1.7 A resolution.
Journal of molecular biology 1982;158(1):111-52.
1981: Weber E; Papamokos E; Bode W; Huber R; Kato I; Laskowski M
Crystallization, crystal structure analysis and molecular model of the third domain of Japanese quail ovomucoid, a Kazal type inhibitor.
Journal of molecular biology 1981;149(1):109-23.
1980: Huber R; Scholze H; Pâques E P; Deisenhofer J
Crystal structure analysis and molecular model of human C3a anaphylatoxin.
Hoppe-Seyler's Zeitschrift für physiologische Chemie 1980;361(9):1389-99.
1980: Marquart M; Deisenhofer J; Huber R; Palm W
Crystallographic refinement and atomic models of the intact immunoglobulin molecule Kol and its antigen-binding fragment at 3.0 A and 1.0 A resolution.
Journal of molecular biology 1980;141(4):369-91.
1979: Ladenstein R; Epp O; Bartels K; Jones A; Huber R; Wendel A
Structure analysis and molecular model of the selenoenzyme glutathione peroxidase at 2.8 A resolution.
Journal of molecular biology 1979;134(2):199-218.
1979: Huber R
Conformational flexibility in protein molecules.
Nature 1979;280(5723):538-9.
1979: Matouschek E; Huber R
[The influence of uric acid on the calcium oxalate stone formation (author's transl)]
Der Urologe. Ausg. A 1979;18(4):211-4.
1979: Matouschek E; Huber R
[Conservative therapy of urolithiasis]
Archivos españoles de urología 1979;32(2):91-104.
1979: Wiegand G; Kukla D; Scholze H; Jones T A; Huber R
Crystal structure analysis of the tetragonal crystal form are preliminary molecular model of pig-heart citrate synthase.
European journal of biochemistry / FEBS 1979;93(1):41-50.
1978: Deisenhofer J; Jones T A; Huber R; Sjödahl J; Sjöquist J
Crystallization, crystal structure analysis and atomic model of the complex formed by a human Fc fragment and fragment B of protein A from Staphylococcus aureus.
Hoppe-Seyler's Zeitschrift für physiologische Chemie 1978;359(8):975-85.
1978: Matsushima M; Marquart M; Jones T A; Colman P M; Bartels K; Huber R
Crystal structure of the human Fab fragment Kol and its comparison with the intact Kol molecule.
Journal of molecular biology 1978;121(4):441-59.
1978: Bode W; Huber R
Crystal structure analysis and refinement of two variants of trigonal trypsinogen: trigonal trypsin and PEG (polyethylene glycol) trypsinogen and their comparison with orthorhombic trypsin and trigonal trypsinogen.
FEBS letters 1978;90(2):265-9.
1978: Weber E; Steigemann W; Jones T A; Huber R
The structure of oxy-erythrocruorin at 1.4 X resolution.
Journal of molecular biology 1978;120(2):327-36.
1978: Bode W; Schwager P; Huber R
The transition of bovine trypsinogen to a trypsin-like state upon strong ligand binding. The refined crystal structures of the bovine trypsinogen-pancreatic trypsin inhibitor complex and of its ternary complex with Ile-Val at 1.9 A resolution.
Journal of molecular biology 1978;118(1):99-112.
1976: Huber R; Deisenhofer J; Colman P M; Matsushima M; Palm W
Crystallographic structure studies of an IgG molecule and an Fc fragment.
Nature 1976;264(5585):415-20.
1976: Bode W; Huber R
Induction of the bovine trypsinogen-trypsin transition by peptides sequentially similar to the N-terminus of trypsin.
FEBS letters 1976;68(2):231-6.
1976: Bode W; Fehlhammer H; Huber R
Crystal structure of bovine trypsinogen at 1-8 A resolution. I. Data collection, application of patterson search techniques and preliminary structural interpretation.
Journal of molecular biology 1976;106(2):325-35.
1976: Hetzel R; Wüthrich K; Deisenhofer J; Huber R
Dynamics of the aromatic amino acid residues in the globular conformation of the basic pancreatic trypsin inhibitor (BPTI). II. Semi-empirical energy calculations.
Biophysics of structure and mechanism 1976;2(2):159-80.
1976: Huber R; Deisenhofer J; Colman P M; Epp O; Fehlhammer H; Palm W
Proceedings: X-ray diffraction analysis of immunoglobulin structure.
Hoppe-Seyler's Zeitschrift für physiologische Chemie 1976;357(5):614-5.
1976: Deisenhofer J; Colman P M; Huber R; Haupt H; Schwick G
Crystallographic structural studies of a human Fc-fragment. I. An electron-density map at 4 A resolution and a partial model.
Hoppe-Seyler's Zeitschrift für physiologische Chemie 1976;357(3):435-45.
1976: Huber R E; Mathison R D
Physical, chemical, and enzymatic studies on the major sucrase of honey bees (Apis mellifera).
Canadian journal of biochemistry 1976;54(2):153-64.
1976: Colman P M; Deisenhofer J; Huber R
Structure of the human antibody molecule Kol (immunoglobulin G1): an electron density map at 5 A resolution.
Journal of molecular biology 1976;100(3):257-78.
1975: Epp O; Lattman E E; Schiffer M; Huber R; Palm W
The molecular structure of a dimer composed of the variable portions of the Bence-Jones protein REI refined at 2.0-A resolution.
Biochemistry 1975;14(22):4943-52.
1975: Huber R; Bode W; Kukla D; Kohl U; Ryan C A
The structure of the complex formed by bovine trypsin and bovine pancreatic trypsin inhibitor III. Structure of the anhydro-trypsin-inhibitor complex.
Biophysics of structure and mechanism 1975;1(3):189-201.
1974: Huber R; Steigemann W
Two cis-prolines in the Bence-Jones protein Rei and the cis-pro-bend.
FEBS letters 1974;48(2):235-7.
1974: Huber R; Kukla D; Bode W; Schwager P; Bartels K; Deisenhofer J; Steigemann W
Structure of the complex formed by bovine trypsin and bovine pancreatic trypsin inhibitor. II. Crystallographic refinement at 1.9 A resolution.
Journal of molecular biology 1974;89(1):73-101.
1974: Epp O; Colman P; Fehlhammer H; Bode W; Schiffer M; Huber R; Palm W
Crystal and molecular structure of a dimer composed of the variable portions of the Bence-Jones protein REI.
European journal of biochemistry / FEBS 1974;45(2):513-24.
1973: Rühlmann A; Kukla D; Schwager P; Bartels K; Huber R
Structure of the complex formed by bovine trypsin and bovine pancreatic trypsin inhibitor. Crystal structure determination and stereochemistry of the contact region.
Journal of molecular biology 1973;77(3):417-36.
1972: Amiconi G; Antonini E; Brunori M; Formaneck H; Huber R
Functional properties of native and reconstituted hemoglobins from Chironomus thummi thummi.
European journal of biochemistry / FEBS 1972;31(1):52-8.
1972: Epp O; Palm W; Fehlhammer H; Rühlmann A; Steigemann W; Schwager P; Huber R
Crystallographic evidence for structurally similar domains in the human kappa-type Bence-Jones protein Rei.
Journal of molecular biology 1972;69(2):315-8.
1972: Blow D M; Wright C S; Kukla D; Rühlmann A; Steigemann W; Huber R
A model for the association of bovine pancreatic trypsin inhibitor with chymotrypsin and trypsin.
Journal of molecular biology 1972;69(1):137-44.
1972: Huber R
Structure of the haemoglobin molecule.
Hämatologie und Bluttransfusion 1972;10():175-6.
1972: Rühlmann A; Schramm H J; Kukla D; Huber R
Pancreatic trypsin inhibitor (Kunitz). II. Complexes with proteinases.
Cold Spring Harbor symposia on quantitative biology 1972;36():148-50.
1972: Huber R; Kukla D; Rühlmann A; Steigemann W
Pancreatic trypsin inhibitor (Kunitz). I. Structure and function.
Cold Spring Harbor symposia on quantitative biology 1972;36():141-8.
1971: Epp O; Steigemann W; Formanek H; Huber R
Crystallographic evidence for the tetrameric subunit structure of L-asparaginase from Escherichia coli.
European journal of biochemistry / FEBS 1971;20(3):432-7.
1971: Huber R; Epp O; Formanek H
pH-induced structural change in erythrocruorin.
Journal of molecular biology 1971;57(2):377-9.
1970: Huber R; Kukla D; Rühlmann A; Epp O; Formanek H
The basic trypsin inhibitor of bovine pancreas. I. Structure analysis and conformation of the polypeptide chain.
Die Naturwissenschaften 1970;57(8):389-92.
1965: Hoppe W; Huber R
[On the chemistry of ecdysone. II. Determination of the skeleton of sterin and its orientation by diffuse x-ray diffraction in ecdysone crystals]
Chemische Berichte 1965;98(7):2353-60.
1964: TEICHMANN B; HUBER R
[ON THE EFFECTS OF IRRADIATED HUMAN SERUM ON THE CRYSTALLIZATION FORMS OF L-LEUCINE.]
International journal of radiation biology and related studies in physics, chemistry, and medicine 1964;8():297-8.

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