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Ulrich Hübscher

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Grigory L Dianov; Ulrich Hübscher
Mammalian base excision repair: the forgotten archangel.
Emmanuele Crespan; Marc M Greenberg; Ulrich Hübscher; Shuhei Imoto; Emanuela Pasi; Giovanni Maga
Human DNA polymerase β, but not λ, can bypass a 2-deoxyribonolactone lesion together with proliferating cell nuclear antigen.
Elisa Zucca; Giuliano Mazzini; Barbara van Loon; Ursula Wimmer; Federica Bertoletti; Grigory Dianov; Elena Ferrari; Nicole Grosse; Ulrich Hübscher; Svetlana Khoronenkova; giovanni maga
Silencing of human DNA polymerase λ causes replication stress and is synthetically lethal with an impaired S phase checkpoint.

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All Publications

2013: Grigory L Dianov; Ulrich Hübscher
Mammalian base excision repair: the forgotten archangel.
Nucleic acids research 2013;41(6):3483-90.
2013: Emmanuele Crespan; Marc M Greenberg; Ulrich Hübscher; Shuhei Imoto; Emanuela Pasi; Giovanni Maga
Human DNA polymerase β, but not λ, can bypass a 2-deoxyribonolactone lesion together with proliferating cell nuclear antigen.
ACS chemical biology 2013;8(2):336-44.
2013: Elisa Zucca; Giuliano Mazzini; Barbara van Loon; Ursula Wimmer; Federica Bertoletti; Grigory Dianov; Elena Ferrari; Nicole Grosse; Ulrich Hübscher; Svetlana Khoronenkova; giovanni maga
Silencing of human DNA polymerase λ causes replication stress and is synthetically lethal with an impaired S phase checkpoint.
Nucleic acids research 2013;41(1):229-41.
2013: Enni Markkanen; Julia Dorn; Ulrich Hübscher
MUTYH DNA glycosylase: the rationale for removing undamaged bases from the DNA.
Frontiers in genetics 2013;4():18.
2012: Enni Markkanen; Giuseppe Villani; Benoît Castrec; Ulrich Hübscher
A switch between DNA polymerases δ and λ promotes error-free bypass of 8-oxo-G lesions.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(50):20401-6.
2012: Radhakrishnan Kanagaraj; Christiane König; Boris Mihaljevic; Prasanna Parasuraman; Barbara van Loon; Vilhelm A Bohr; Kamila Burdova; Antonia Furrer; Ulrich Hübscher; Pavel Janscak
Involvement of Werner syndrome protein in MUTYH-mediated repair of oxidative DNA damage.
Nucleic acids research 2012;40(17):8449-59.
2012: Emmanuele Crespan; Tibor Czabany; giovanni maga; Ulrich Hübscher
Microhomology-mediated DNA strand annealing and elongation by human DNA polymerases λ and β on normal and repetitive DNA sequences.
Nucleic acids research 2012;40(12):5577-90.
2012: Enni Markkanen; Ulrich Hübscher; Barbara van Loon
Regulation of oxidative DNA damage repair: the adenine:8-oxo-guanine problem.
Cell cycle (Georgetown, Tex.) 2012;11(6):1070-5.
2011: Mayura Meerang; Hemmo Meyer; Shreya Paliwal; Matthias Bosshard; Zuzana Garajova; Ulrich Hübscher; Pavel Janscak; Niels Mailand; Danilo Ritz; Kristijan Ramadan
The ubiquitin-selective segregase VCP/p97 orchestrates the response to DNA double-strand breaks.
Nature cell biology 2011;13(11):1376-82.
2011: Ulrich Hübscher; Giovanni Maga
DNA replication and repair bypass machines.
Current opinion in chemical biology 2011;15(5):627-35.
2011: Enni Markkanen; Barbara van Loon; Elena Ferrari; Ulrich Hübscher
Ubiquitylation of DNA polymerase λ.
FEBS letters 2011;585(18):2826-30.
2010: Barbara van Loon; Enni Markkanen; Ulrich Hübscher
Oxygen as a friend and enemy: How to combat the mutational potential of 8-oxo-guanine.
DNA repair 2010;9(6):604-16.
2009: Barbara van Loon; Ulrich Hübscher
An 8-oxo-guanine repair pathway coordinated by MUTYH glycosylase and DNA polymerase lambda.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(43):18201-6.
2009: Barbara van Loon; Elena Ferrari; Ulrich Hübscher
Isolation of recombinant DNA elongation proteins.
Methods in molecular biology (Clifton, N.J.) 2009;521():345-59.
2009: Ulrich Hübscher
DNA replication fork proteins.
Methods in molecular biology (Clifton, N.J.) 2009;521():19-33.
2008: Ursula Wimmer; Elena Ferrari; Peter Hunziker; Ulrich Hübscher
Control of DNA polymerase lambda stability by phosphorylation and ubiquitination during the cell cycle.
EMBO reports 2008;9(10):1027-33.
2008: Nives Selak; Csanád Z Bachrati; Igor Shevelev; Tobias Dietschy; Barbara van Loon; Anette Jacob; Ulrich Hübscher; Joerg D Hoheisel; Ian D Hickson; Igor Stagljar
The Bloom's syndrome helicase (BLM) interacts physically and functionally with p12, the smallest subunit of human DNA polymerase delta.
Nucleic acids research 2008;36(16):5166-79.
2008: Samantha Zanoli; Sandra Gemma; Stefania Butini; Margherita Brindisi; Bhupendra P Joshi; Giuseppe Campiani; Caterina Fattorusso; Marco Persico; Emmanuele Crespan; Reynel Cancio; Silvio Spadari; Ulrich Hübscher; giovanni maga
Selective targeting of the HIV-1 reverse transcriptase catalytic complex through interaction with the "primer grip" region by pyrrolobenzoxazepinone non-nucleoside inhibitors correlates with increased activity towards drug-resistant mutants.
Biochemical pharmacology 2008;76(2):156-68.
2008: Melanie Blasius; Suzanne Sommer; Ulrich Hübscher
Deinococcus radiodurans: what belongs to the survival kit?
Critical reviews in biochemistry and molecular biology 2008;43(3):221-38.
2008: giovanni maga; Ulrich Hübscher
Repair and translesion DNA polymerases as anticancer drug targets.
Anti-cancer agents in medicinal chemistry 2008;8(4):431-47.
2008: Ekaterina A Belousova; Emmanuele Crespan; Natalia A Lebedeva; Nadejda I Rechkunova; Ulrich Hübscher; Giovanni Magaand; Olga I Lavrik
Photoreactive DNA probes as a tool for studying the translesion synthesis system in Mammalian cell extracts.
Medicinal chemistry (Shāriqah (United Arab Emirates)) 2008;4(2):155-62.
2007: Elielson Souza-Rodrígues; Josep Maria Estanyol; Erica Friedrich-Heineken; Eva Olmedo; Jorge Vera; Núria Canela; Sonia Brun; Neus Agell; Ulrich Hübscher; Oriol Bachs; Montserrat Jaumot
Proteomic analysis of p16ink4a-binding proteins.
Proteomics 2007;7(22):4102-11.
2007: Laurence Meslet-Cladiére; Cedric Norais; Joëlle Kuhn; Julien Briffotaux; Jerry W Sloostra; Elena Ferrari; Ulrich Hübscher; Didier Flament; Hannu Myllykallio
A novel proteomic approach identifies new interaction partners for proliferating cell nuclear antigen.
Journal of molecular biology 2007;372(5):1137-48.
2007: giovanni maga; Giuseppe Villani; Emmanuele Crespan; Ursula Wimmer; Elena Ferrari; Barbara Bertocci; Ulrich Hübscher
8-oxo-guanine bypass by human DNA polymerases in the presence of auxiliary proteins.
Nature 2007;447(7144):606-8.
2007: Reynel Cancio; Antonello Mai; Dante Rotili; Marino Artico; Gianluca Sbardella; Imma Clotet-Codina; José A Esté; Emmanuele Crespan; Samantha Zanoli; Ulrich Hübscher; Silvio Spadari; giovanni maga
Slow-, tight-binding HIV-1 reverse transcriptase non-nucleoside inhibitors highly active against drug-resistant mutants.
ChemMedChem 2007;2(4):445-8.
2007: Emmanuele Crespan; Ulrich Hübscher; giovanni maga
Error-free bypass of 2-hydroxyadenine by human DNA polymerase lambda with Proliferating Cell Nuclear Antigen and Replication Protein A in different sequence contexts.
Nucleic acids research 2007;35(15):5173-81.
2007: Agnieszka Gembka; Magali Toueille; Ekaterina Smirnova; Rainer Poltz; Elena Ferrari; Giuseppe Villani; Ulrich Hübscher
The checkpoint clamp, Rad9-Rad1-Hus1 complex, preferentially stimulates the activity of apurinic/apyrimidinic endonuclease 1 and DNA polymerase beta in long patch base excision repair.
Nucleic acids research 2007;35(8):2596-608.
2007: giovanni maga; Marco Radi; Samantha Zanoli; Fabrizio Manetti; Reynel Cancio; Ulrich Hübscher; Silvio Spadari; Chiara Falciani; Montserrat Terrazas; Jaume Vilarrasa; Maurizio Botta
Discovery of non-nucleoside inhibitors of HIV-1 reverse transcriptase competing with the nucleotide substrate.
Angewandte Chemie (International ed. in English) 2007;46(11):1810-3.
2007: Emmanuele Crespan; Ludmila Alexandrova; Anastasiya Khandazhinskaya; Maxim V Jasko; Marina K Kukhanova; Giuseppe Villani; Ulrich Hübscher; Silvio Spadari; giovanni maga
Expanding the repertoire of DNA polymerase substrates: template-instructed incorporation of non-nucleoside triphosphate analogues by DNA polymerases beta and lambda.
Nucleic acids research 2007;35(1):45-57.
2007: Nazim El-Andaloussi; Taras Valovka; Magali Toueille; Paul O Hassa; Peter Gehrig; Marcela Covic; Ulrich Hübscher; Michael Hottiger
Methylation of DNA polymerase beta by protein arginine methyltransferase 1 regulates its binding to proliferating cell nuclear antigen.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007;21(1):26-34.
2006: Nazim El-Andaloussi; Taras Valovka; Magali Toueille; Roland Steinacher; Frauke Focke; Peter Gehrig; Marcela Covic; Paul O Hassa; Primo Schär; Ulrich Hübscher; Michael Hottiger
Arginine methylation regulates DNA polymerase beta.
Molecular cell 2006;22(1):51-62.
2006: Melanie Blasius; Igor Shevelev; Edmond Jolivet; Suzanne Sommer; Ulrich Hübscher
DNA polymerase X from Deinococcus radiodurans possesses a structure-modulated 3'-->5' exonuclease activity involved in radioresistance.
Molecular microbiology 2006;60(1):165-76.
2006: giovanni maga; Igor Shevelev; Giuseppe Villani; Silvio Spadari; Ulrich Hübscher
Human replication protein A can suppress the intrinsic in vitro mutator phenotype of human DNA polymerase lambda.
Nucleic acids research 2006;34(5):1405-15.
2005: Erica Friedrich-Heineken; Magali Toueille; Barbara Tännler; Christine Bürki; Elena Ferrari; Michael Hottiger; Ulrich Hübscher
The two DNA clamps Rad9/Rad1/Hus1 complex and proliferating cell nuclear antigen differentially regulate flap endonuclease 1 activity.
Journal of molecular biology 2005;353(5):980-9.
2005: Reynel Cancio; Romano Silvestri; Rino Ragno; Marino Artico; Gabriella De Martino; Giuseppe La Regina; Emmanuele Crespan; Samantha Zanoli; Ulrich Hübscher; Silvio Spadari; giovanni maga
High potency of indolyl aryl sulfone nonnucleoside inhibitors towards drug-resistant human immunodeficiency virus type 1 reverse transcriptase mutants is due to selective targeting of different mechanistic forms of the enzyme.
Antimicrobial agents and chemotherapy 2005;49(11):4546-54.
2005: Giada A Locatelli; Roberto Di Santo; Emmanuele Crespan; Roberta Costi; Alessandra Roux; Ulrich Hübscher; Igor Shevelev; Giuseppina Blanca; Giuseppe Villani; Silvio Spadari; giovanni maga
Diketo hexenoic acid derivatives are novel selective non-nucleoside inhibitors of mammalian terminal deoxynucleotidyl transferases, with potent cytotoxic effect against leukemic cells.
Molecular pharmacology 2005;68(2):538-50.
2005: Giada A Locatelli; Monica Savio; Luca Forti; Igor Shevelev; Kristijan Ramadan; Lucia A Stivala; Vanio Vannini; Ulrich Hübscher; Silvio Spadari; giovanni maga
Inhibition of mammalian DNA polymerases by resveratrol: mechanism and structural determinants.
The Biochemical journal 2005;389(Pt 2):259-68.
2005: Ghislaine Henneke; Didier Flament; Ulrich Hübscher; Joël Querellou; Jean-Paul Raffin
The hyperthermophilic euryarchaeota Pyrococcus abyssi likely requires the two DNA polymerases D and B for DNA replication.
Journal of molecular biology 2005;350(1):53-64.
2005: Ekaterina Smirnova; Magali Toueille; Enni Markkanen; Ulrich Hübscher
The human checkpoint sensor and alternative DNA clamp Rad9-Rad1-Hus1 modulates the activity of DNA ligase I, a component of the long-patch base excision repair machinery.
The Biochemical journal 2005;389(Pt 1):13-7.
2005: giovanni maga; Kristijan Ramadan; Giada A Locatelli; Igor Shevelev; Silvio Spadari; Ulrich Hübscher
DNA elongation by the human DNA polymerase lambda polymerase and terminal transferase activities are differentially coordinated by proliferating cell nuclear antigen and replication protein A.
The Journal of biological chemistry 2005;280(3):1971-81.
2005: Sudha Sharma; Joshua Sommers; Ronald K Gary; Erica Friedrich-Heineken; Ulrich Hübscher; Robert M Brosh
The interaction site of Flap Endonuclease-1 with WRN helicase suggests a coordination of WRN and PCNA.
Nucleic acids research 2005;33(21):6769-81.
2005: Isabelle Frouin; Magali Toueille; Elena Ferrari; Igor Shevelev; Ulrich Hübscher
Phosphorylation of human DNA polymerase lambda by the cyclin-dependent kinase Cdk2/cyclin A complex is modulated by its association with proliferating cell nuclear antigen.
Nucleic acids research 2005;33(16):5354-61.
2005: Emmanuele Crespan; Samantha Zanoli; Anastasiya Khandazhinskaya; Igor Shevelev; Maxim V Jasko; Ludmila Alexandrova; Marina K Kukhanova; Giuseppina Blanca; Giuseppe Villani; Ulrich Hübscher; Silvio Spadari; giovanni maga
Incorporation of non-nucleoside triphosphate analogues opposite to an abasic site by human DNA polymerases beta and lambda.
Nucleic acids research 2005;33(13):4117-27.
2005: Emmanuele Crespan; Giada A Locatelli; Reynel Cancio; Ulrich Hübscher; Silvio Spadari; giovanni maga
Drug resistance mutations in the nucleotide binding pocket of human immunodeficiency virus type 1 reverse transcriptase differentially affect the phosphorolysis-dependent primer unblocking activity in the presence of stavudine and zidovudine and its inhibition by efavirenz.
Antimicrobial agents and chemotherapy 2005;49(1):342-9.
2004: Kristijan Ramadan; Igor Shevelev; Ulrich Hübscher
The DNA-polymerase-X family: controllers of DNA quality?
Nature reviews. Molecular cell biology 2004;5(12):1038-43.
2004: giovanni maga; Giuseppina Blanca; Igor Shevelev; Isabelle Frouin; Kristijan Ramadan; Silvio Spadari; Giuseppe Villani; Ulrich Hübscher
The human DNA polymerase lambda interacts with PCNA through a domain important for DNA primer binding and the interaction is inhibited by p21/WAF1/CIP1.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(14):1743-5.
2004: Giuseppina Blanca; Giuseppe Villani; Igor Shevelev; Kristijan Ramadan; Silvio Spadari; Ulrich Hübscher; giovanni maga
Human DNA polymerases lambda and beta show different efficiencies of translesion DNA synthesis past abasic sites and alternative mechanisms for frameshift generation.
Biochemistry 2004;43(36):11605-15.
2004: Magali Toueille; Ulrich Hübscher
Regulation of the DNA replication fork: a way to fight genomic instability.
Chromosoma 2004;113(3):113-25.
2004: Kristijan Ramadan; Igor V Shevelev; giovanni maga; Ulrich Hübscher
De novo DNA synthesis by human DNA polymerase lambda, DNA polymerase mu and terminal deoxyribonucleotidyl transferase.
Journal of molecular biology 2004;339(2):395-404.
2004: Giada A Locatelli; Giuseppe Campiani; Reynel Cancio; Elena Morelli; Anna Ramunno; Sandra Gemma; Ulrich Hübscher; Silvio Spadari; giovanni maga
Effects of drug resistance mutations L100I and V106A on the binding of pyrrolobenzoxazepinone nonnucleoside inhibitors to the human immunodeficiency virus type 1 reverse transcriptase catalytic complex.
Antimicrobial agents and chemotherapy 2004;48(5):1570-80.
2004: Magali Toueille; Nazim El-Andaloussi; Isabelle Frouin; Raimundo Freire; Dorothee Funk; Igor Shevelev; Erica Friedrich-Heineken; Giuseppe Villani; Michael Hottiger; Ulrich Hübscher
The human Rad9/Rad1/Hus1 damage sensor clamp interacts with DNA polymerase beta and increases its DNA substrate utilisation efficiency: implications for DNA repair.
Nucleic acids research 2004;32(11):3316-24.
2004: Erica Friedrich-Heineken; Ulrich Hübscher
The Fen1 extrahelical 3'-flap pocket is conserved from archaea to human and regulates DNA substrate specificity.
Nucleic acids research 2004;32(8):2520-8.
2003: Igor Shevelev; Giuseppina Blanca; Giuseppe Villani; Kristijan Ramadan; Silvio Spadari; Ulrich Hübscher; giovanni maga
Mutagenesis of human DNA polymerase lambda: essential roles of Tyr505 and Phe506 for both DNA polymerase and terminal transferase activities.
Nucleic acids research 2003;31(23):6916-25.
2003: Ghislaine Henneke; Stéphane Koundrioukoff; Ulrich Hübscher
Phosphorylation of human Fen1 by cyclin-dependent kinase modulates its role in replication fork regulation.
Oncogene 2003;22(28):4301-13.
2003: Fausto Baldanti; Stefania Paolucci; giovanni maga; Nazzarena Labo; Ulrich Hübscher; Alexander Yu Skoblov; Lyubov Victorova; Silvio Spadari; Lorenzo Minoli; Giuseppe Gerna
Nevirapine-selected mutations Y181I/C of HIV-1 reverse transcriptase confer cross-resistance to stavudine.
AIDS (London, England) 2003;17(10):1568-70.
2003: Ghislaine Henneke; Erica Friedrich-Heineken; Ulrich Hübscher
Flap endonuclease 1: a novel tumour suppresser protein.
Trends in biochemical sciences 2003;28(7):384-90.
2003: Giuseppina Blanca; Igor Shevelev; Kristijan Ramadan; Giuseppe Villani; Silvio Spadari; Ulrich Hübscher; giovanni maga
Human DNA polymerase lambda diverged in evolution from DNA polymerase beta toward specific Mn(++) dependence: a kinetic and thermodynamic study.
Biochemistry 2003;42(24):7467-76.
2003: Taurai Tasara; Bernhard Angerer; Martine Damond; Holger Winter; Sabine Dörhöfer; Ulrich Hübscher; Mario Amacker
Incorporation of reporter molecule-labeled nucleotides by DNA polymerases. II. High-density labeling of natural DNA.
Nucleic acids research 2003;31(10):2636-46.
2003: Giuseppina Blanca; Fausto Baldanti; Stefania Paolucci; Alexander Yu Skoblov; Lyubov Victorova; Ulrich Hübscher; Giuseppe Gerna; Silvio Spadari; giovanni maga
Nevirapine resistance mutation at codon 181 of the HIV-1 reverse transcriptase confers stavudine resistance by increasing nucleotide substrate discrimination and phosphorolytic activity.
The Journal of biological chemistry 2003;278(18):15469-72.
2003: Erica Friedrich-Heineken; Ghislaine Henneke; Elena Ferrari; Ulrich Hübscher
The acetylatable lysines of human Fen1 are important for endo- and exonuclease activities.
Journal of molecular biology 2003;328(1):73-84.
2003: Kristijan Ramadan; giovanni maga; Igor V Shevelev; Giuseppe Villani; Luis Blanco; Ulrich Hübscher
Human DNA polymerase lambda possesses terminal deoxyribonucleotidyl transferase activity and can elongate RNA primers: implications for novel functions.
Journal of molecular biology 2003;328(1):63-72.
2003: Ghislaine Henneke; Stéphane Koundrioukoff; Ulrich Hübscher
Multiple roles for kinases in DNA replication.
EMBO reports 2003;4(3):252-6.
2002: giovanni maga; Giuseppe Villani; Kristijan Ramadan; Igor Shevelev; Nicolas Tanguy Le Gac; Luis Blanco; Giuseppina Blanca; Silvio Spadari; Ulrich Hübscher
Human DNA polymerase lambda functionally and physically interacts with proliferating cell nuclear antigen in normal and translesion DNA synthesis.
The Journal of biological chemistry 2002;277(50):48434-40.
2002: Ghislaine Henneke; Yannick Gueguen; Didier Flament; Philippe Azam; Joël Querellou; Jacques Dietrich; Ulrich Hübscher; Jean-Paul Raffin
Replication factor C from the hyperthermophilic archaeon Pyrococcus abyssi does not need ATP hydrolysis for clamp-loading and contains a functionally conserved RFC PCNA-binding domain.
Journal of molecular biology 2002;323(5):795-810.
2002: Francesca Storici; Ghislaine Henneke; Elena Ferrari; Dmitry A Gordenin; Ulrich Hübscher; Michael A Resnick
The flexible loop of human FEN1 endonuclease is required for flap cleavage during DNA replication and repair.
The EMBO journal 2002;21(21):5930-42.
2002: Dr. Kirsten Dahm; Ulrich Hübscher
Colocalization of human Rad17 and PCNA in late S phase of the cell cycle upon replication block.
Oncogene 2002;21(50):7710-9.
2002: giovanni maga; Igor Shevelev; Kristijan Ramadan; Silvio Spadari; Ulrich Hübscher
DNA polymerase theta purified from human cells is a high-fidelity enzyme.
Journal of molecular biology 2002;319(2):359-69.
2002: Kristijan Ramadan; Igor V Shevelev; giovanni maga; Ulrich Hübscher
DNA polymerase lambda from calf thymus preferentially replicates damaged DNA.
The Journal of biological chemistry 2002;277(21):18454-8.
2002: Isabelle Frouin; Alessandra Montecucco; Giuseppe Biamonti; Ulrich Hübscher; Silvio Spadari; giovanni maga
Cell cycle-dependent dynamic association of cyclin/Cdk complexes with human DNA replication proteins.
The EMBO journal 2002;21(10):2485-95.
2002: Barbara Pascucci; giovanni maga; Ulrich Hübscher; M Bjoras; E Seeberg; I D Hickson; G Villani; C Giordano; Luciano Cellai; Eugenia Dogliotti
Reconstitution of the base excision repair pathway for 7,8-dihydro-8-oxoguanine with purified human proteins.
Nucleic acids research 2002;30(10):2124-30.
2002: Igor V Shevelev; Ulrich Hübscher
The 3' 5' exonucleases.
Nature reviews. Molecular cell biology 2002;3(5):364-76.
2002: Igor V Shevelev; Kristijan Ramadan; Ulrich Hübscher
The TREX2 3'-->5' exonuclease physically interacts with DNA polymerase delta and increases its accuracy.
TheScientificWorldJournal 2002;2():275-81.
2001: M Ducoux; serge urbach; Giuseppe Baldacci; Ulrich Hübscher; Stéphane Koundrioukoff; J Christensen; Patrick Hughes
Mediation of proliferating cell nuclear antigen (PCNA)-dependent DNA replication through a conserved p21(Cip1)-like PCNA-binding motif present in the third subunit of human DNA polymerase delta.
The Journal of biological chemistry 2001;276(52):49258-66.
2001: giovanni maga; Giuseppe Villani; V Tillement; Manuel Stucki; Giada A Locatelli; Isabelle Frouin; Silvio Spadari; Ulrich Hübscher
Okazaki fragment processing: modulation of the strand displacement activity of DNA polymerase delta by the concerted action of replication protein A, proliferating cell nuclear antigen, and flap endonuclease-1.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(25):14298-303.
2001: Ulrich Hübscher; Y S Seo
Replication of the lagging strand: a concert of at least 23 polypeptides.
Molecules and cells 2001;12(2):149-57.
2001: Taurai Tasara; giovanni maga; Michael Hottiger; Ulrich Hübscher
HIV-1 reverse transcriptase and integrase enzymes physically interact and inhibit each other.
FEBS letters 2001;507(1):39-44.
2001: A Ziemienowicz; I Konieczny; Ulrich Hübscher
Calf thymus Hsc70 and Hsc40 can substitute for DnaK and DnaJ function in protein renaturation but not in bacteriophage DNA replication.
FEBS letters 2001;507(1):11-5.
2001: M Missura; Tonko Buterin; Robert Hindges; Ulrich Hübscher; Jana Kaspárková; Viktor Brabec; Hanspeter Naegeli
Double-check probing of DNA bending and unwinding by XPA-RPA: an architectural function in DNA repair.
The EMBO journal 2001;20(13):3554-64.
2001: Taurai Tasara; Michael Hottiger; Ulrich Hübscher
Functional genomics in HIV-1 virus replication: protein-protein interactions as a basis for recruiting the host cell machinery for viral propagation.
Biological chemistry 2001;382(7):993-9.
2001: Sameez Hasan; Manuel Stucki; Paul O Hassa; Ralph Imhof; Peter Gehrig; Peter Hunziker; Ulrich Hübscher; Michael Hottiger
Regulation of human flap endonuclease-1 activity by acetylation through the transcriptional coactivator p300.
Molecular cell 2001;7(6):1221-31.
2001: giovanni maga; Ulrich Hübscher; Massimo Pregnolato; Daniela Ubiali; Gilles Gosselin; Silvio Spadari
Potentiation of inhibition of wild-type and mutant human immunodeficiency virus type 1 reverse transcriptases by combinations of nonnucleoside inhibitors and d- and L-(beta)-dideoxynucleoside triphosphate analogs.
Antimicrobial agents and chemotherapy 2001;45(4):1192-200.
2001: Manuel Stucki; ZO Jónsson; Ulrich Hübscher
In eukaryotic flap endonuclease 1, the C terminus is essential for substrate binding.
The Journal of biological chemistry 2001;276(11):7843-9.
2001: R Hobi; Ulrich Hübscher; K Neftel; E Alteri; B Poncioni; MR Walker; K Woods-Cook; P Schneider; Janis Lazdins
Anti-HIV-1 activity in vitro of ceftazidime degradation products.
Antiviral chemistry & chemotherapy 2001;12(2):109-18.
2001: Manuel Stucki; Igor Stagljar; ZO Jónsson; Ulrich Hübscher
A coordinated interplay: proteins with multiple functions in DNA replication, DNA repair, cell cycle/checkpoint control, and transcription.
Progress in nucleic acid research and molecular biology 2001;65():261-98.
2000: Ghislaine Henneke; Jean-Paul Raffin; Elena Ferrari; Z O Jónsson; Jacques Dietrich; Ulrich Hübscher
The PCNA from Thermococcus fumicolans functionally interacts with DNA polymerase delta.
Biochemical and biophysical research communications 2000;276(2):600-6.
2000: Stéphane Koundrioukoff; ZO Jónsson; Sameez Hasan; Rob N de Jong; Peter C van der Vliet; Michael Hottiger; Ulrich Hübscher
A direct interaction between proliferating cell nuclear antigen (PCNA) and Cdk2 targets PCNA-interacting proteins for phosphorylation.
The Journal of biological chemistry 2000;275(30):22882-7.
2000: Ulrich Hübscher; Heinz Nasheuer; Juhani E Syväoja
Eukaryotic DNA polymerases, a growing family.
Trends in biochemical sciences 2000;25(3):143-7.
2000: R Mossi; Robert Conrad Keller; Elena Ferrari; Ulrich Hübscher
DNA polymerase switching: II. Replication factor C abrogates primer synthesis by DNA polymerase alpha at a critical length.
Journal of molecular biology 2000;295(4):803-14.
2000: giovanni maga; Manuel Stucki; Silvio Spadari; Ulrich Hübscher
DNA polymerase switching: I. Replication factor C displaces DNA polymerase alpha prior to PCNA loading.
Journal of molecular biology 2000;295(4):791-801.
2000: S B Schumacher; Manuel Stucki; Ulrich Hübscher
The N-terminal region of DNA polymerase delta catalytic subunit is necessary for holoenzyme function.
Nucleic acids research 2000;28(2):620-5.
1999: Barbara Pascucci; Manuel Stucki; ZO Jónsson; Eugenia Dogliotti; Ulrich Hübscher
Long patch base excision repair with purified human proteins. DNA ligase I as patch size mediator for DNA polymerases delta and epsilon.
The Journal of biological chemistry 1999;274(47):33696-702.
1999: Robert Conrad Keller; R Mossi; giovanni maga; Ralf E Wellinger; Ulrich Hübscher; José M Sogo
Electron microscopic analysis reveals that replication factor C is sequestered by single-stranded DNA.
Nucleic acids research 1999;27(17):3433-7.
1999: Igor Stagljar; Ulrich Hübscher; Alcide Barberis
Activation of DNA replication in yeast by recruitment of the RNA polymerase II transcription complex.
Biological chemistry 1999;380(5):525-30.
1999: giovanni maga; Mario Amacker; Ulrich Hübscher; Gilles Gosselin; Jean-Louis Imbach; Christophe Mathé; Abdesslem Faraj; Jean-Pierre Sommadossi; Silvio Spadari
Structural determinants of HIV-1 reverse transcriptase stereoselectivity towards (beta)-L-deoxy- and dideoxy-pyrimidine nucleoside triphosphates: molecular basis for the combination of L-dideoxynucleoside analogs with non-nucleoside inhibitors in anti HIV chemotherapy.
Nucleosides & nucleotides 1999;18(4-5):795-805.
1999: giovanni maga; Mario Amacker; Ulrich Hübscher; Gilles Gosselin; Jean-Louis Imbach; Christophe Mathé; Abdesslem Faraj; Jean-Pierre Sommadossi; Silvio Spadari
Molecular basis for the enantioselectivity of HIV-1 reverse transcriptase: role of the 3'-hydroxyl group of the L-(beta)-ribose in chiral discrimination between D- and L-enantiomers of deoxy- and dideoxy-nucleoside triphosphate analogs.
Nucleic acids research 1999;27(4):972-8.
1999: Taurai Tasara; Mario Amacker; Ulrich Hübscher
Intramolecular chimeras of the p51 subunit between HIV-1 and FIV reverse transcriptases suggest a stabilizing function for the p66 subunit in the heterodimeric enzyme.
Biochemistry 1999;38(5):1633-42.
1999: Andreas Marx; M Spichty; Mario Amacker; U Schwitter; Ulrich Hübscher; Thomas A Bickle; giovanni maga; Bernd Giese
Probing interactions between HIV-1 reverse transcriptase and its DNA substrate with backbone-modified nucleotides.
Chemistry & biology 1999;6(2):111-6.
1999: giovanni maga; ZO Jónsson; Manuel Stucki; Silvio Spadari; Ulrich Hübscher
Dual mode of interaction of DNA polymerase epsilon with proliferating cell nuclear antigen in primer binding and DNA synthesis.
Journal of molecular biology 1999;285(1):259-67.
1998: M Perderiset; giovanni maga; K Piard; Stefania Francesconi; Isabelle Tratner; Ulrich Hübscher; Giuseppe Baldacci
Mutant DNA polymerase delta from thermosensitive Schizosaccharomyces pombe strains display reduced stimulation by proliferating cell nuclear antigen.
The Biochemical journal 1998;335 ( Pt 3)():581-8.
1998: Andreas Marx; Mario Amacker; M Stucki; Ulrich Hübscher; Thomas A Bickle; Bernd Giese
4'-Acylated thymidine 5'-triphosphates: a tool to increase selectivity towards HIV-1 reverse transcriptase.
Nucleic acids research 1998;26(17):4063-7.
1998: Manuel Stucki; Barbara Pascucci; Eleonora Parlanti; Paola Fortini; S H Wilson; Ulrich Hübscher; Eugenia Dogliotti
Mammalian base excision repair by DNA polymerases delta and epsilon.
Oncogene 1998;17(7):835-43.
1998: R Mossi; Elena Ferrari; Ulrich Hübscher
DNA ligase I selectively affects DNA synthesis by DNA polymerases delta and epsilon suggesting differential functions in DNA replication and repair.
The Journal of biological chemistry 1998;273(23):14322-30.
1998: R Mossi; Ulrich Hübscher
Clamping down on clamps and clamp loaders--the eukaryotic replication factor C.
European journal of biochemistry / FEBS 1998;254(2):209-16.
1998: Mario Amacker; Ulrich Hübscher
Chimeric HIV-1 and feline immunodeficiency virus reverse transcriptases: critical role of the p51 subunit in the structural integrity of heterodimeric lentiviral DNA polymerases.
Journal of molecular biology 1998;278(4):757-65.
1998: ZO Jónsson; Robert Hindges; Ulrich Hübscher
Regulation of DNA replication and repair proteins through interaction with the front side of proliferating cell nuclear antigen.
The EMBO journal 1998;17(8):2412-25.
1998: Peter Schurtenberger; Stefan U Egelhaaf; Robert Hindges; giovanni maga; ZO Jónsson; R P May; Otto Glatter; Ulrich Hübscher
The solution structure of functionally active human proliferating cell nuclear antigen determined by small-angle neutron scattering.
Journal of molecular biology 1998;275(1):123-32.
1997: giovanni maga; Mario Amacker; N Ruel; Ulrich Hübscher; Silvio Spadari
Resistance to nevirapine of HIV-1 reverse transcriptase mutants: loss of stabilizing interactions and thermodynamic or steric barriers are induced by different single amino acid substitutions.
Journal of molecular biology 1997;274(5):738-47.
1997: ZO Jónsson; Ulrich Hübscher
Proliferating cell nuclear antigen: more than a clamp for DNA polymerases.
BioEssays : news and reviews in molecular, cellular and developmental biology 1997;19(11):967-75.
1997: Robert Hindges; Ulrich Hübscher
Cloning, chromosomal localization, and interspecies interaction of mouse DNA polymerase delta small subunit (PolD2).
Genomics 1997;44(1):45-51.
1997: giovanni maga; R Mossi; R Fischer; MW Berchtold; Ulrich Hübscher
Phosphorylation of the PCNA binding domain of the large subunit of replication factor C by Ca2+/calmodulin-dependent protein kinase II inhibits DNA synthesis.
Biochemistry 1997;36(18):5300-10.
1997: Robert Hindges; Ulrich Hübscher
DNA polymerase delta, an essential enzyme for DNA transactions.
Biological chemistry 1997;378(5):345-62.
1997: M Amacker; M Hottiger; R Mossi; Ulrich Hübscher
HIV-1 nucleocapsid protein and replication protein A influence the strand displacement DNA synthesis of lentiviral reverse transcriptase.
AIDS (London, England) 1997;11(4):534-6.
1997: R Mossi; ZO Jónsson; B L Allen; Susan H Hardin; Ulrich Hübscher
Replication factor C interacts with the C-terminal side of proliferating cell nuclear antigen.
The Journal of biological chemistry 1997;272(3):1769-76.
1996: Rati Fotedar; R Mossi; P Fitzgerald; T Rousselle; giovanni maga; H Brickner; H Messier; S Kasibhatla; Ulrich Hübscher; Arun Fotedar
A conserved domain of the large subunit of replication factor C binds PCNA and acts like a dominant negative inhibitor of DNA replication in mammalian cells.
The EMBO journal 1996;15(16):4423-33.
1996: M Knibiehler; F Goubin; N Escalas; Z O Jónsson; Honoré Mazarguil; Ulrich Hübscher; BERNARD DUCOMMUN
Interaction studies between the p21Cip1/Waf1 cyclin-dependent kinase inhibitor and proliferating cell nuclear antigen (PCNA) by surface plasmon resonance.
FEBS letters 1996;391(1-2):66-70.
1996: giovanni maga; Ulrich Hübscher
DNA replication machinery: functional characterization of a complex containing DNA polymerase alpha, DNA polymerase delta, and replication factor C suggests an asymmetric DNA polymerase dimer.
Biochemistry 1996;35(18):5764-77.
1996: Michael J Lutz; H A Held; M Hottiger; Ulrich Hübscher; S A Benner
Differential discrimination of DNA polymerase for variants of the non-standard nucleobase pair between xanthosine and 2,4-diaminopyrimidine, two components of an expanded genetic alphabet.
Nucleic acids research 1996;24(7):1308-13.
1996: M Hottiger; Ulrich Hübscher
Human Immunodeficiency Virus type 1 reverse transcriptase.
Biological chemistry Hoppe-Seyler 1996;377(2):97-120.
1996: P Werner; Susi Arnold; Claude Schelling; Ulrich Hübscher
[Analysis of microsatellite polymorphisms in Bernese mountain dogs and Newfoundlands].
Schweizer Archiv für Tierheilkunde 1996;138(3):152-6.
1996: K Allenspach; Mario Amacker; Christian M Leutenegger; M Hottiger; Regina Hofmann-Lehmann; Ulrich Hübscher; M Pistello; Hans Lutz
[Quantification of proviral FIV DNA using competitive PCR].
Schweizer Archiv für Tierheilkunde 1996;138(2):87-92.
1996: M W Berchtold; Ulrich Hübscher
[PCR: basics and new developments].
Schweizer Archiv für Tierheilkunde 1996;138(2):53-8.
1995: ZO Jónsson; V N Podust; L M Podust; Ulrich Hübscher
Tyrosine 114 is essential for the trimeric structure and the functional activities of human proliferating cell nuclear antigen.
The EMBO journal 1995;14(22):5745-51.
1995: Mario Amacker; M Hottiger; Ulrich Hübscher
Feline immunodeficiency virus reverse transcriptase: expression, functional characterization, and reconstitution of the 66- and 51-kilodalton subunits.
Journal of virology 1995;69(10):6273-9.
1995: V N Podust; L M Podust; F Goubin; BERNARD DUCOMMUN; Ulrich Hübscher
Mechanism of inhibition of proliferating cell nuclear antigen-dependent DNA synthesis by the cyclin-dependent kinase inhibitor p21.
Biochemistry 1995;34(27):8869-75.
1995: J Horlacher; M Hottiger; V N Podust; Ulrich Hübscher; S A Benner
Recognition by viral and cellular DNA polymerases of nucleosides bearing bases with nonstandard hydrogen bonding patterns.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(14):6329-33.
1995: A Ziemienowicz; Maciej Zylicz; C Floth; Ulrich Hübscher
Calf thymus Hsc70 protein protects and reactivates prokaryotic and eukaryotic enzymes.
The Journal of biological chemistry 1995;270(26):15479-84.
1995: Robert Hindges; Ulrich Hübscher
Production of active mouse DNA polymerase delta in bacteria.
Gene 1995;158(2):241-6.
1995: L M Podust; V N Podust; J M Sogo; Ulrich Hübscher
Mammalian DNA polymerase auxiliary proteins: analysis of replication factor C-catalyzed proliferating cell nuclear antigen loading onto circular double-stranded DNA.
Molecular and cellular biology 1995;15(6):3072-81.
1995: V N Podust; L M Podust; F Müller; Ulrich Hübscher
DNA polymerase delta holoenzyme: action on single-stranded DNA and on double-stranded DNA in the presence of replicative DNA helicases.
Biochemistry 1995;34(15):5003-10.
1995: M Hottiger; K Gramatikoff; Oleg Georgiev; C Chaponnier; Walter Schaffner; Ulrich Hübscher
The large subunit of HIV-1 reverse transcriptase interacts with beta-actin.
Nucleic acids research 1995;23(5):736-41.
1995: giovanni maga; Ulrich Hübscher
DNA polymerase epsilon interacts with proliferating cell nuclear antigen in primer recognition and elongation.
Biochemistry 1995;34(3):891-901.
1995: P Werner; J P Siegfried; Ulrich Hübscher
[DNA fingerprinting in wild equid and Poitou ass breeding].
Schweizer Archiv für Tierheilkunde 1995;137(8):395-7.
1994: L M Podust; V N Podust; C Floth; Ulrich Hübscher
Assembly of DNA polymerase delta and epsilon holoenzymes depends on the geometry of the DNA template.
Nucleic acids research 1994;22(15):2970-5.
1994: A Georgaki; N Tuteja; B Sturzenegger; Ulrich Hübscher
Calf thymus DNA helicase F, a replication protein A copurifying enzyme.
Nucleic acids research 1994;22(7):1128-34.
1994: M Hottiger; V N Podust; R L Thimmig; C McHenry; Ulrich Hübscher
Strand displacement activity of the human immunodeficiency virus type 1 reverse transcriptase heterodimer and its individual subunits.
The Journal of biological chemistry 1994;269(2):986-91.
1993: G Cullmann; Robert Hindges; MW Berchtold; Ulrich Hübscher
Cloning of a mouse cDNA encoding DNA polymerase delta: refinement of the homology boxes.
Gene 1993;134(2):191-200.
1993: G Cullmann; Ulrich Hübscher; MW Berchtold
A reliable protocol for dsDNA and PCR product sequencing.
BioTechniques 1993;15(4):578-9.
1993: A Georgaki; Ulrich Hübscher
DNA unwinding by replication protein A is a property of the 70 kDa subunit and is facilitated by phosphorylation of the 32 kDa subunit.
Nucleic acids research 1993;21(16):3659-65.
1993: V N Podust; Ulrich Hübscher
Lagging strand DNA synthesis by calf thymus DNA polymerases alpha, beta, delta and epsilon in the presence of auxiliary proteins.
Nucleic acids research 1993;21(4):841-6.
1992: V N Podust; A Georgaki; B Strack; Ulrich Hübscher
Calf thymus RF-C as an essential component for DNA polymerase delta and epsilon holoenzymes function.
Nucleic acids research 1992;20(16):4159-65.
1992: A Georgaki; B Strack; V Podust; Ulrich Hübscher
DNA unwinding activity of replication protein A.
FEBS letters 1992;308(3):240-4.
1992: Annalisa Verri; S Verzeletti; P Mazzarello; Silvio Spadari; M Negri; G Bunone; G Della Valle; Ulrich Hübscher; Federico Focher
DNA synthesis enzymes and proliferating cell nuclear antigen in normal and neoplastic nerve cells.
Anticancer research 1992;12(4):1099-105.
1992: P Thömmes; Ulrich Hübscher
Eukaryotic DNA helicases: essential enzymes for DNA transactions.
Chromosoma 1992;101(8):467-73.
1992: P Thömmes; E Ferrari; R Jessberger; Ulrich Hübscher
Four different DNA helicases from calf thymus.
The Journal of biological chemistry 1992;267(9):6063-73.
1992: Ulrich Hübscher; P Thömmes
DNA polymerase epsilon: in search of a function.
Trends in biochemical sciences 1992;17(2):55-8.
1992: V Podust; V Mikhailov; A Georgaki; Ulrich Hübscher
DNA polymerase delta and epsilon holoenzymes from calf thymus.
Chromosoma 1992;102(1 Suppl):S133-41.
1991: P Hafkemeyer; K Neftel; R Hobi; A Pfaltz; Hans Lutz; K Lüthi; F Focher; S Spadari; Ulrich Hübscher
HP 0.35, a cephalosporin degradation product is a specific inhibitor of lentiviral RNAses H.
Nucleic acids research 1991;19(15):4059-65.
1991: P Hafkemeyer; E Ferrari; J Brecher; Ulrich Hübscher
The p15 carboxyl-terminal proteolysis product of the human immunodeficiency virus type 1 reverse transcriptase p66 has DNA polymerase activity.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(12):5262-66.
1991: T Weiser; Max Gassmann; P Thömmes; E Ferrari; P Hafkemeyer; Ulrich Hübscher
Biochemical and functional comparison of DNA polymerases alpha, delta, and epsilon from calf thymus.
The Journal of biological chemistry 1991;266(16):10420-8.
1991: Ulrich Hübscher
[DNA diagnosis in veterinary medicine: II. Polymerase chain reaction (PCR)].
Schweizer Archiv für Tierheilkunde 1991;133(1):27-31.
1991: Claude Schelling; E Clavadetscher; E Schärer; P E Thomann; C C Kuenzle; Ulrich Hübscher
Two-dimensional DNA-fingerprinting in animals.
EXS 1991;58():283-93.
1991: Claude Schelling; P E Thomann; Ulrich Hübscher
[DNA diagnosis in veterinary medicine: I. DNA fingerprinting].
Schweizer Archiv für Tierheilkunde 1991;133(1):13-22.
1990: P Thömmes; Ulrich Hübscher
Eukaryotic DNA replication. Enzymes and proteins acting at the fork.
European journal of biochemistry / FEBS 1990;194(3):699-712.
1990: P Thömmes; Ulrich Hübscher
DNA helicase from calf thymus. Purification to apparent homogeneity and biochemical characterization of the enzyme.
The Journal of biological chemistry 1990;265(24):14347-54.
1990: P Thömmes; Ulrich Hübscher
Eukaryotic DNA helicases.
FEBS letters 1990;268(2):325-8.
1990: Max Gassmann; P Thömmes; T Weiser; Ulrich Hübscher
Efficient production of chicken egg yolk antibodies against a conserved mammalian protein.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1990;4(8):2528-32.
1990: Federico Focher; P Mazzarello; Annalisa Verri; Ulrich Hübscher; Silvio Spadari
Activity profiles of enzymes that control the uracil incorporation into DNA during neuronal development.
Mutation research 1990;237(2):65-73.
1990: Max Gassmann; T Weiser; P Thömmes; Ulrich Hübscher
[The chicken egg as a supply of polyclonal antibodies].
Schweizer Archiv für Tierheilkunde 1990;132(6):289-94.
1990: Federico Focher; Annalisa Verri; giovanni maga; Silvio Spadari; Ulrich Hübscher
Effect of divalent and monovalent cations on calf thymus PCNA-independent DNA polymerase delta and its 3'----5' exonuclease.
FEBS letters 1990;259(2):349-52.
1990: P Hafkemeyer; K A Neftel; Ulrich Hübscher
HIV-reverse transcriptase and human DNA polymerase alpha share amino acid sequence homologies to bacterial penicillin-binding proteins.
Methods and findings in experimental and clinical pharmacology 1990;12(1):43-6.
1989: Silvio Spadari; Alessandra Montecucco; G Pedrali-Noy; G Ciarrocchi; Federico Focher; Ulrich Hübscher
A double-loop model for the replication of eukaryotic DNA.
Mutation research 1989;219(3):147-56.
1989: F Focher; Max Gassmann; P Hafkemeyer; E Ferrari; S Spadari; Ulrich Hübscher
Calf thymus DNA polymerase delta independent of proliferating cell nuclear antigen (PCNA).
Nucleic acids research 1989;17(5):1805-21.
1988: Max Gassmann; F Focher; H J Buhk; E Ferrari; S Spadari; Ulrich Hübscher
Replication of single-stranded porcine circovirus DNA by DNA polymerases alpha and delta.
Biochimica et biophysica acta 1988;951(2-3):280-9.
1988: E Signer; C C Kuenzle; P E Thomann; Ulrich Hübscher
Modified gel electrophoresis for higher resolution of DNA fingerprints.
Nucleic acids research 1988;16(15):7739.
1988: E Signer; C C Kuenzle; P E Thomann; Ulrich Hübscher
DNA fingerprinting: improved DNA extraction from small blood samples.
Nucleic acids research 1988;16(15):7738.
1988: F Focher; S Spadari; B Ginelli; M Hottiger; Max Gassmann; Ulrich Hübscher
Calf thymus DNA polymerase delta: purification, biochemical and functional properties of the enzyme after its separation from DNA polymerase alpha, a DNA dependent ATPase and proliferating cell nuclear antigen.
Nucleic acids research 1988;16(14A):6279-95.
1988: F Focher; E Ferrari; S Spadari; Ulrich Hübscher
Do DNA polymerases delta and alpha act coordinately as leading and lagging strand replicases?
FEBS letters 1988;229(1):6-10.
1987: U H Do; K A Neftel; S Spadari; Ulrich Hübscher
Betalactam antibiotics interfere with eukaryotic DNA-replication by inhibiting DNA polymerase alpha.
Nucleic acids research 1987;15(24):10495-506.
1987: Ulrich Hübscher; Max Gassmann; S Spadari; Neal C Brown; E Ferrari; H J Buhk
Mammalian DNA polymerase alpha: a replication-competent holoenzyme form from calf thymus.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1987;317(1187):421-8.
1986: Ulrich Hübscher; U D Huynh; Michael Hässig; K A Neftel
Effects of beta-lactams on DNA replication.
Cell biology and toxicology 1986;2(4):541-8.
1983: Ulrich Hübscher
The mammalian primase is part of a high molecular weight DNA polymerase alpha polypeptide.
The EMBO journal 1983;2(1):133-6.