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Alan Hudson

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Robin J Tyacke; Christine A Parker; Emma S J Robinson; Emma M Turner; Amy Fisher; Peter Grundt; Alan L Hudson; Stephen M Husbands; David J Nutt
Evaluation and initial in vitro and ex vivo characterization of the potential positron emission tomography ligand, BU99008 (2-(4,5-dihydro-1H-imidazol-2-yl)-1- methyl-1H-indole), for the imidazoline₂ binding site.
Franciszek Sączewski; Anita Kornicka; Alan L Hudson; Shayna Laird; Mika Scheinin; Jonne M Laurila; Apolonia Rybczyńska; Konrad Boblewski; Artur Lehmann; Maria Gdaniec
3-[(Imidazolidin-2-yl)imino]indazole ligands with selectivity for the α(2)-adrenoceptor compared to the imidazoline I(1) receptor.
Jaroslaw Saczewski; Alan L Hudson; Apolonia Rybczyńska
2-[(Arylmethoxy)imino]imidazolidines with potential biological activities.

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All Publications

2012: Robin J Tyacke; Christine A Parker; Emma S J Robinson; Emma M Turner; Amy Fisher; Peter Grundt; Alan L Hudson; Stephen M Husbands; David J Nutt
Evaluation and initial in vitro and ex vivo characterization of the potential positron emission tomography ligand, BU99008 (2-(4,5-dihydro-1H-imidazol-2-yl)-1- methyl-1H-indole), for the imidazoline₂ binding site.
Synapse (New York, N.Y.) 2012;66(6):542-51.
2011: Franciszek Sączewski; Anita Kornicka; Alan L Hudson; Shayna Laird; Mika Scheinin; Jonne M Laurila; Apolonia Rybczyńska; Konrad Boblewski; Artur Lehmann; Maria Gdaniec
3-[(Imidazolidin-2-yl)imino]indazole ligands with selectivity for the α(2)-adrenoceptor compared to the imidazoline I(1) receptor.
Bioorganic & medicinal chemistry 2011;19(1):321-9.
2009: Jaroslaw Saczewski; Alan L Hudson; Apolonia Rybczyńska
2-[(Arylmethoxy)imino]imidazolidines with potential biological activities.
Acta poloniae pharmaceutica 2009;66(6):671-80.
2009: Anita Kornicka; Alan L Hudson; Patrick J Bednarski
Synthesis and biological activity of some 2-imidazolinylhydrazone derivatives.
Acta poloniae pharmaceutica 2009;66(5):523-34.
2009: Atsuko Kimura; Robin J Tyacke; James J Robinson; Stephen M Husbands; Michael C W Minchin; David J Nutt; Alan L Hudson
Identification of an imidazoline binding protein: creatine kinase and an imidazoline-2 binding site.
Brain research 2009;1279():21-8.
2007: Haya Abu Ghazaleh; Margaret D Lalies; Stephen M Husbands; David J Nutt; Alan L Hudson
The effect of 1-(4,5-dihydro-1H-imidazol-2-yl) isoquinoline on monoamine release and turnover in the rat frontal cortex.
Neuroscience letters 2007;422(2):109-13.
2007: Louise M Paterson; Robin J Tyacke; Emma S J Robinson; David J Nutt; Alan L Hudson
In vitro and in vivo effect of BU99006 (5-isothiocyanato-2-benzofuranyl-2-imidazoline) on I2 binding in relation to MAO: evidence for two distinct I2 binding sites.
Neuropharmacology 2007;52(2):395-404.
2006: Franciszek Saczewski; Piotr Tabin; Robin J Tyacke; Alys Maconie; Jaroslaw Saczewski; Anita Kornicka; David J Nutt; Alan L Hudson
2-(4,5-Dihydroimidazol-2-yl)benzimidazoles as highly selective imidazoline I2/adrenergic alpha2 receptor ligands.
Bioorganic & medicinal chemistry 2006;14(19):6679-85.
2006: Neil J Anderson; Isabelle Seif; David J Nutt; Alan L Hudson; Emma S J Robinson
Autoradiographical distribution of imidazoline binding sites in monoamine oxidase A deficient mice.
Journal of neurochemistry 2006;96(6):1551-9.
2006: Neil J Anderson; Robin J Tyacke; Stephen M Husbands; David J Nutt; Alan L Hudson; Emma S J Robinson
In vitro and ex vivo distribution of [3H]harmane, an endogenous beta-carboline, in rat brain.
Neuropharmacology 2006;50(3):269-76.
2005: Anita Kornicka; Franciszek Saczewski; Robin J Tyacke; Alan L Hudson; David J Nutt
Preparation, structure and affinity for imidazoline I2 receptors and alpha2-adrenoceptors of 1-[(4,5-dihydroimidazolidin-2-yl)imino]indan-2-ols.
Acta poloniae pharmaceutica 2005;62(6):497-502.
2005: Neil J Anderson; Patrick A Lupo; David J Nutt; Alan L Hudson; Emma S J Robinson
Characterisation of imidazoline I2 binding sites in pig brain.
European journal of pharmacology 2005;519(1-2):68-74.
2005: Emma S J Robinson; David J Nutt; Helen C Jackson; Alan L Hudson
The uptake of a fluorescently labelled antisense oligonucleotide in vitro and in vivo.
Journal of neuroscience methods 2005;147(1):48-54.
2005: David A Slattery; John A Morrow; Alan L Hudson; David R Hill; David J Nutt; Brian Henry
Comparison of alterations in c-fos and Egr-1 (zif268) expression throughout the rat brain following acute administration of different classes of antidepressant compounds.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2005;30(7):1278-87.
2005: Franciszek Saczewski; Ewa Kobierska; Robin J Tyacke; Alan L Hudson; David J Nutt; Maria Gdaniec
Synthesis of 2,3,5,6-tetrahydro-3H-imidazo[2,1-b] [1,3,5]benzotriazepines and their oxidative ring contraction into 1-(4,5-dihydro-1H-imidazol-2-yl)-1H-benzimidazoles.
Farmaco (Società chimica italiana : 1989) 2005;60(2):127-34.
2005: Robin J Tyacke; Emma S J Robinson; Margaret D Lalies; Susan P Hume; Alan L Hudson; David J Nutt
Estimation of endogenous noradrenaline release in rat brain in vivo using [3H]RX 821002.
Synapse (New York, N.Y.) 2005;55(2):126-32.
2004: Christine A Parker; Neil J Anderson; Emma S J Robinson; Rhiannon Price; Robin J Tyacke; Stephen M Husbands; Michael P Dillon; Richard M Eglen; Alan L Hudson; David J Nutt; Matthew Crump; John Crosby
Harmane and harmalan are bioactive components of classical clonidine-displacing substance.
Biochemistry 2004;43(51):16385-92.
2004: Emma S J Robinson; Robin J Tyacke; Louise Finch; Graham Willmott; Stephen M Husbands; David J Nutt; Alan L Hudson
Pharmacological characterisation of novel alpha 2-adrenoceptor antagonists as potential brain imaging agents.
Neuropharmacology 2004;46(6):847-55.
2004: David P Finn; Alan L Hudson; Hiroshi Kinoshita; Toni L Coventry; David S Jessop; David J Nutt; Michael S Harbuz
Imidazoline2 (I2) receptor- and alpha2-adrenoceptor-mediated modulation of hypothalamic-pituitary-adrenal axis activity in control and acute restraint stressed rats.
Journal of psychopharmacology (Oxford, England) 2004;18(1):47-53.
2004: Jean Chang-Fong; Robin J Tyacke; Alice Lau; Julie Westaway; Alan L Hudson; Richard A Glennon
Pyrazino[1,2-a]indoles as novel high-affinity and selective imidazoline I(2) receptor ligands.
Bioorganic & medicinal chemistry letters 2004;14(4):1003-5.
2004: Richard A Glennon; Brian Grella; Robin J Tyacke; Alice Lau; Julie Westaway; Alan L Hudson
Binding of beta-carbolines at imidazoline I2 receptors: a structure-affinity investigation.
Bioorganic & medicinal chemistry letters 2004;14(4):999-1002.
2004: David A Slattery; Alan L Hudson; David J Nutt
Invited review: the evolution of antidepressant mechanisms.
Fundamental & clinical pharmacology 2004;18(1):1-21.
2004: Richard A Glennon; Brian Grella; Robin J Tyacke; Alice Lau; Julie Westaway; Alan L Hudson
Binding of an imidazopyridoindole at imidazoline I2 receptors.
Bioorganic & medicinal chemistry letters 2004;14(2):527-9.
2003: E Jane Cooper; Alan L Hudson; Christine A Parker; Noel G Morgan
Effects of the beta-carbolines, harmane and pinoline, on insulin secretion from isolated human islets of Langerhans.
European journal of pharmacology 2003;482(1-3):189-96.
2003: Louise M Paterson; Emma S J Robinson; David J Nutt; Alan L Hudson
In vivo estimation of imidazoline(2) binding site turnover.
Annals of the New York Academy of Sciences 2003;1009():367-70.
2003: A Kimura; Robin J Tyacke; M C W Minchin; David J Nutt; Alan L Hudson
Identification of an I(2) binding protein from rabbit brain.
Annals of the New York Academy of Sciences 2003;1009():364-6.
2003: Robin J Tyacke; Alice Lau; Brian Grella; Richard A Glennon; David J Nutt; Alan L Hudson
Investigation of the affinities of two new beta-carbolines for rat brain imidazoline(2) receptors.
Annals of the New York Academy of Sciences 2003;1009():361-3.
2003: Robin J Tyacke; F Sazczewski; Piotr Tabin; J Sazczewski; David J Nutt; Alan L Hudson
Initial evaluation of novel selective ligands for imidazoline(2) receptors in rat whole brain.
Annals of the New York Academy of Sciences 2003;1009():357-60.
2003: Louise M Paterson; Robin J Tyacke; David J Nutt; Alan L Hudson
Relationship between imidazoline(2) sites and monoamine oxidase.
Annals of the New York Academy of Sciences 2003;1009():353-6.
2003: Alan L Hudson; Robin J Tyacke; Margaret D Lalies; N Davies; David P Finn; Octavi Marti; E Robinson; Stephen M Husbands; M C W Minchin; A Kimura; David J Nutt
Novel ligands for the investigation of imidazoline receptors and their binding proteins.
Annals of the New York Academy of Sciences 2003;1009():302-8.
2003: Emma S J Robinson; R E Price; David J Nutt; Alan L Hudson
BU98008, a highly selective imidazoline(1)-receptor ligand.
Annals of the New York Academy of Sciences 2003;1009():283-7.
2003: Neil J Anderson; Emma S J Robinson; Stephen M Husbands; P Delagrange; David J Nutt; Alan L Hudson
Characterization of [(3)H]harmane binding to rat whole brain membranes.
Annals of the New York Academy of Sciences 2003;1009():175-9.
2003: Noel G Morgan; E Jane Cooper; Paul E Squires; Claire E Hills; Christine A Parker; Alan L Hudson
Comparative effects of efaroxan and beta-carbolines on the secretory activity of rodent and human beta cells.
Annals of the New York Academy of Sciences 2003;1009():167-74.
2003: Emma S J Robinson; Neil J Anderson; John Crosby; David J Nutt; Alan L Hudson
Endogenous beta-carbolines as clonidine-displacing substances.
Annals of the New York Academy of Sciences 2003;1009():157-66.
2003: Franciszek Saczewski; Alan L Hudson; Robin J Tyacke; David J Nutt; J Man; Piotr Tabin; Jaroslaw Saczewski
2-(4,5-dihydro-1H-imidazol-2-yl)indazole (indazim) derivatives as selective I(2) imidazoline receptor ligands.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2003;20(2):201-8.
2003: David P Finn; Octavi Marti; Michael S Harbuz; Astrid Vallès; Xavier Belda; Cristina Márquez; David S Jessop; Margaret D Lalies; Antonio Armario; David J Nutt; Alan L Hudson
Behavioral, neuroendocrine and neurochemical effects of the imidazoline I2 receptor selective ligand BU224 in naive rats and rats exposed to the stress of the forced swim test.
Psychopharmacology 2003;167(2):195-202.
2002: Emma S J Robinson; Robin J Tyacke; David J Nutt; Alan L Hudson
Distribution of [(3)H]BU224, a selective imidazoline I(2) binding site ligand, in rat brain.
European journal of pharmacology 2002;450(1):55-60.
2002: Robin J Tyacke; Emma S J Robinson; David J Nutt; Alan L Hudson
5-Isothiocyanato-2-benzofuranyl-2-imidazoline (BU99006) an irreversible imidazoline(2) binding site ligand: in vitro and in vivo characterisation in rat brain.
Neuropharmacology 2002;43(1):75-83.
2002: David P Finn; Margaret D Lalies; Michael S Harbuz; David S Jessop; Alan L Hudson; David J Nutt
Imidazoline(2) (I(2)) binding site- and alpha(2)-adrenoceptor-mediated modulation of central noradrenergic and HPA axis function in control rats and chronically stressed rats with adjuvant-induced arthritis.
Neuropharmacology 2002;42(7):958-65.
2002: Robin J Tyacke; Emma S J Robinson; Rebecca Schnabel; John W Lewis; Stephen M Husbands; David J Nutt; Alan L Hudson
N1'-fluoroethyl-naltrindole (BU97001) and N1'-fluoroethyl-(14-formylamino)-naltrindole (BU97018) potential delta-opioid receptor PET ligands.
Nuclear medicine and biology 2002;29(4):455-62.
2001: Stephen M Husbands; R A Glennon; S Gorgerat; R Gough; Robin J Tyacke; John Crosby; David J Nutt; John W Lewis; Alan L Hudson
beta-carboline binding to imidazoline receptors.
Drug and alcohol dependence 2001;64(2):203-8.
2001: J Clayson; Andrew R Jales; Robin J Tyacke; Alan L Hudson; David J Nutt; John W Lewis; Stephen M Husbands
Selective delta-opioid receptor ligands: potential PET ligands based on naltrindole.
Bioorganic & medicinal chemistry letters 2001;11(7):939-43.
2000: Emma S J Robinson; David J Nutt; Helen C Jackson; Alan L Hudson
Behavioural and physiological effects induced by an infusion of antisense to alpha(2D)-adrenoceptors in the rat.
British journal of pharmacology 2000;130(1):153-9.
2000: P A Coates; Peter Grundt; Emma S J Robinson; David J Nutt; Robin J Tyacke; Alan L Hudson; John W Lewis; Stephen M Husbands
Probes for imidazoline binding sites: synthesis and evaluation of a selective, irreversible I2 ligand.
Bioorganic & medicinal chemistry letters 2000;10(6):605-7.
2000: Christine A Parker; Alan L Hudson; David J Nutt; Michael P Dillon; Richard M Eglen; John Crosby
Isolation of RP-HPLC pure clonidine-displacing substance from NG108-15 cells.
European journal of pharmacology 2000;387(1):27-30.
2000: Emma S J Robinson; Alan L Hudson
In vitro and in vivo effects of antisense on alpha 2-adrenoceptor expression.
Methods in enzymology 2000;314():61-76.
1999: Alan L Hudson; Emma S J Robinson; Margaret D Lalies; Robin J Tyacke; Helen C Jackson; David J Nutt
In vitro and in vivo approaches to the characterization of the alpha2-adrenoceptor.
Journal of autonomic pharmacology 1999;19(6):311-20.
1999: Emma S J Robinson; David J Nutt; L Hall; Helen C Jackson; Alan L Hudson
Autoradiographical and behavioural effects of a chronic infusion of antisense to the alpha2D-adrenoceptor in the rat.
British journal of pharmacology 1999;128(3):515-22.
1999: Christine A Parker; Alan L Hudson; David J Nutt; Michael P Dillon; Richard M Eglen; S L Chan; Noel G Morgan; John Crosby
Extraction of active clonidine-displacing substance from bovine lung and comparison with clonidine-displacing substance extracted from other tissues.
European journal of pharmacology 1999;378(2):213-21.
1999: Alan L Hudson; S Luscombe; R E Gouch; David J Nutt; Robin J Tyacke
Endogenous indoleamines demonstrate moderate affinity for I2 binding sites.
Annals of the New York Academy of Sciences 1999;881():212-6.
1999: Robin J Tyacke; David J Nutt; Alan L Hudson
Autoradiography of I2 receptors in frog brain.
Annals of the New York Academy of Sciences 1999;881():208-11.
1999: Margaret D Lalies; A Hibell; Alan L Hudson; David J Nutt
Inhibition of central monoamine oxidase by imidazoline2 site-selective ligands.
Annals of the New York Academy of Sciences 1999;881():114-7.
1999: Christine A Parker; Alan L Hudson; David J Nutt; Michael P Dillon; Richard M Eglen; John Crosby
Comparison of crude methanolic CDS extracts from various tissues.
Annals of the New York Academy of Sciences 1999;881():92-6.
1999: Alan L Hudson; R Gough; Robin J Tyacke; LA Lione; Margaret D Lalies; J Lewis; Stephen M Husbands; P Knight; Fraser Murray; Peter H Hutson; David J Nutt
Novel selective compounds for the investigation of imidazoline receptors.
Annals of the New York Academy of Sciences 1999;881():81-91.
1999: Alan L Hudson; LA Lione
Characterization of imidazoline receptors by radioligand binding.
Methods in molecular biology (Clifton, N.J.) 1999;106():37-47.
1998: J W Dalley; Christine A Parker; E Wülfert; Alan L Hudson; David J Nutt
Potentiation of barbiturate-induced alterations in presynaptic noradrenergic function in rat frontal cortex by imidazol(in)e alpha2-adrenoceptor agonists.
British journal of pharmacology 1998;125(3):441-6.
1998: Richard M Eglen; Alan L Hudson; D A Kendall; David J Nutt; Noel G Morgan; V G Wilson; Michael P Dillon
'Seeing through a glass darkly': casting light on imidazoline 'I' sites.
Trends in pharmacological sciences 1998;19(9):381-90.
1998: LA Lione; David J Nutt; Alan L Hudson
Characterisation and localisation of [3H]2-(2-benzofuranyl)-2-imidazoline binding in rat brain: a selective ligand for imidazoline I2 receptors.
European journal of pharmacology 1998;353(1):123-35.
1997: N G Bowery; David R Hill; Alan L Hudson
Characteristics of GABAB receptor binding sites on rat whole brain synaptic membranes. 1983.
British journal of pharmacology 1997;120(4 Suppl):452-67; discussion 450-1.
1997: Emma S J Robinson; David J Nutt; Helen C Jackson; Alan L Hudson
Antisense oligonucleotides in psychopharmacology and behaviour: promises and pitfalls.
Journal of psychopharmacology (Oxford, England) 1997;11(3):259-69.
1997: David J Nutt; Margaret D Lalies; LA Lione; Alan L Hudson
Noradrenergic mechanisms in the prefrontal cortex.
Journal of psychopharmacology (Oxford, England) 1997;11(2):163-8.
1997: Alan L Hudson; C B Chapleo; J W Lewis; Stephen M Husbands; K Grivas; N J Mallard; David J Nutt
Identification of ligands selective for central I2-imidazoline binding sites.
Neurochemistry international 1997;30(1):47-53.
1996: LA Lione; David J Nutt; Alan L Hudson
[3H]2-(2-benzofuranyl)-2-imidazoline: a new selective high affinity radioligand for the study of rabbit brain imidazoline I2 receptors.
European journal of pharmacology 1996;304(1-3):221-9.
1994: Gareth Hicks; Alan L Hudson; Graeme Henderson
Localization of high affinity [3H]glibenclamide binding sites within the substantia nigra zona reticulata of the rat brain.
Neuroscience 1994;61(2):285-92.
1992: N J Mallard; Alan L Hudson; David J Nutt
Characterization and autoradiographical localization of non-adrenoceptor idazoxan binding sites in the rat brain.
British journal of pharmacology 1992;106(4):1019-27.