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Stephane Huet

Research Profile

Chemicals & Drugs

Disorders

Liver Cirrhosis

Living Beings

Phenomena

Phosphorylation

Concepts & Ideas

Structure-Activity Relationship

Physiology

Anatomy

Livers

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Publications

TOP 3
M Petersen; M Thorikay; Martine M L Deckers; M van Dinther; Eugene T Grygielko; Françoise Gellibert; Anne-Charlotte de Gouville; Stephane Huet; Peter ten Dijke; Nicholas J Laping
Oral administration of GW788388, an inhibitor of TGF-beta type I and II receptor kinases, decreases renal fibrosis.
Kendall Frazier; Roberta Thomas; Marshall Scicchitano; Rosanna Mirabile; Rogely Boyce; Dawn Zimmerman; Eugene T Grygielko; James Nold; Anne-Charlotte DeGouville; Stephane Huet; Nicholas J Laping; Françoise Gellibert
Inhibition of ALK5 signaling induces physeal dysplasia in rats.
Françoise Gellibert; Anne-Charlotte de Gouville; James M Woolven; Neil Mathews; Van-Loc Nguyen; Cécile Bertho-Ruault; Angela Patikis; Eugene T Grygielko; Nicholas J Laping; Stephane Huet
Discovery of 4-{4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]pyridin-2-yl}-N-(tetrahydro-2H- pyran-4-yl)benzamide (GW788388): a potent, selective, and orally active transforming growth factor-beta type I receptor inhibitor.

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All Publications

2008: M Petersen; M Thorikay; Martine M L Deckers; M van Dinther; Eugene T Grygielko; Françoise Gellibert; Anne-Charlotte de Gouville; Stephane Huet; Peter ten Dijke; Nicholas J Laping
Oral administration of GW788388, an inhibitor of TGF-beta type I and II receptor kinases, decreases renal fibrosis.
Kidney international 2008;73(6):705-15.
2007: Kendall Frazier; Roberta Thomas; Marshall Scicchitano; Rosanna Mirabile; Rogely Boyce; Dawn Zimmerman; Eugene T Grygielko; James Nold; Anne-Charlotte DeGouville; Stephane Huet; Nicholas J Laping; Françoise Gellibert
Inhibition of ALK5 signaling induces physeal dysplasia in rats.
Toxicologic pathology 2007;35(2):284-95.
2006: Françoise Gellibert; Anne-Charlotte de Gouville; James M Woolven; Neil Mathews; Van-Loc Nguyen; Cécile Bertho-Ruault; Angela Patikis; Eugene T Grygielko; Nicholas J Laping; Stephane Huet
Discovery of 4-{4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]pyridin-2-yl}-N-(tetrahydro-2H- pyran-4-yl)benzamide (GW788388): a potent, selective, and orally active transforming growth factor-beta type I receptor inhibitor.
Journal of medicinal chemistry 2006;49(7):2210-21.
2006: Anne-Charlotte de Gouville; Stephane Huet
Inhibition of ALK5 as a new approach to treat liver fibrotic diseases.
Drug news & perspectives 2006;19(2):85-90.
2005: Anne-Charlotte de Gouville; Valerie Boullay; Gael Krysa; Julia Pilot; Jean-Marie Brusq; Florence Loriolle; Jean-Michel Gauthier; Stephen A Papworth; Alain Laroze; Françoise Gellibert; Stephane Huet
Inhibition of TGF-beta signaling by an ALK5 inhibitor protects rats from dimethylnitrosamine-induced liver fibrosis.
British journal of pharmacology 2005;145(2):166-77.
2004: Françoise Gellibert; James M Woolven; Marie-Hélène Fouchet; Neil Mathews; Helen Goodland; Victoria Lovegrove; Alain Laroze; Van-Loc Nguyen; Stéphane Sautet; Ruolan Wang; Cheryl Janson; Ward Smith; Gaël Krysa; Valérie Boullay; Anne-Charlotte de Gouville; Stephane Huet; David Hartley
Identification of 1,5-naphthyridine derivatives as a novel series of potent and selective TGF-beta type I receptor inhibitors.
Journal of medicinal chemistry 2004;47(18):4494-506.
2001: Valérie Paradis; G Perlemuter; Frank Bonvoust; Delphine Dargere; B Parfait; Michel Vidaud; M Conti; Stephane Huet; Nathalie Ba; C Buffet; Pierre Bedossa
High glucose and hyperinsulinemia stimulate connective tissue growth factor expression: a potential mechanism involved in progression to fibrosis in nonalcoholic steatohepatitis.
Hepatology (Baltimore, Md.) 2001;34(4 Pt 1):738-44.
1999: Valérie Paradis; Delphine Dargere; Michel Vidaud; Anne-Charlotte de Gouville; Stephane Huet; V Martinez; Jean-Michel Gauthier; Nathalie Ba; R Sobesky; Vlad Ratziu; Pierre Bedossa
Expression of connective tissue growth factor in experimental rat and human liver fibrosis.
Hepatology (Baltimore, Md.) 1999;30(4):968-76.
1999: S Dennler; Stephane Huet; Jean-Michel Gauthier
A short amino-acid sequence in MH1 domain is responsible for functional differences between Smad2 and Smad3.
Oncogene 1999;18(8):1643-8.
1998: S Dennler; S Itoh; D Vivien; Peter ten Dijke; Stephane Huet; Jean-Michel Gauthier
Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene.
The EMBO journal 1998;17(11):3091-100.
1997: F X Weill; S Blazejewski; Jean-Frédéric Blanc; Stephane Huet; Jean-Michel Gauthier; Véronique Neaud; Elvira Olaso; Liliane Dubuisson; Véronique Braesco; Fernando Vidal-Vanaclocha; Charles Balabaud; Paulette Bioulac-Sage; Jean Rosenbaum
Characterization of a new human liver myofibroblast cell line: transcriptional regulation of plasminogen activator inhibitor type I by transforming growth factor beta 1.
Laboratory investigation; a journal of technical methods and pathology 1997;77(1):63-70.