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Leonard Augenlicht

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Derek M Huffman; John J Lofrese; Gil Atzmon; Leonard H Augenlicht; John P Chamberland; Xueying Zhang; Christos S Mantzoros
Abdominal obesity, independent from caloric intake, accounts for the development of intestinal tumors in Apc(1638N/+) female mice.
Claire Bastie; Elena Dhima; Erin Gaffney-Stomberg; Ting-Wen A Lee; Jeffrey Pessin; Leonard H Augenlicht
Dietary cholecalciferol and calcium levels in a Western-style defined rodent diet alter energy metabolism and inflammatory responses in mice.
Do-Sun Byun; Georgia A Corner; Dustin J Flanagan; SANJAY GOEL; Shannon Nasser; Joongho Shin; Elizabeth Vincan; David S Williams; Andrew J Wilson; Naseem Ahmed; Sheren Al-Obaidi; Leonard H Augenlicht; John M Mariadason
Intestinal epithelial-specific PTEN inactivation results in tumor formation.

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2013: Derek M Huffman; John J Lofrese; Gil Atzmon; Leonard H Augenlicht; John P Chamberland; Xueying Zhang; Christos S Mantzoros
Abdominal obesity, independent from caloric intake, accounts for the development of intestinal tumors in Apc(1638N/+) female mice.
Cancer prevention research (Philadelphia, Pa.) 2013;6(3):177-87.
2012: Claire Bastie; Elena Dhima; Erin Gaffney-Stomberg; Ting-Wen A Lee; Jeffrey Pessin; Leonard H Augenlicht
Dietary cholecalciferol and calcium levels in a Western-style defined rodent diet alter energy metabolism and inflammatory responses in mice.
The Journal of nutrition 2012;142(5):859-65.
2011: Do-Sun Byun; Georgia A Corner; Dustin J Flanagan; SANJAY GOEL; Shannon Nasser; Joongho Shin; Elizabeth Vincan; David S Williams; Andrew J Wilson; Naseem Ahmed; Sheren Al-Obaidi; Leonard H Augenlicht; John M Mariadason
Intestinal epithelial-specific PTEN inactivation results in tumor formation.
American journal of physiology. Gastrointestinal and liver physiology 2011;301(5):G856-64.
2011: Michael Papetti; Leonard H Augenlicht
Mybl2, downregulated during colon epithelial cell maturation, is suppressed by miR-365.
American journal of physiology. Gastrointestinal and liver physiology 2011;301(3):G508-18.
2011: Donghai Wang; Elena Dhima; Elaine Y Lin; John M Mariadason; Karina Peregrina; Leonard H Augenlicht
Paneth cell marker expression in intestinal villi and colon crypts characterizes dietary induced risk for mouse sporadic intestinal cancer.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(25):10272-7.
2011: Michael Papetti; Leonard H Augenlicht
MYBL2, a link between proliferation and differentiation in maturing colon epithelial cells.
Journal of cellular physiology 2011;226(3):785-91.
2011: Michele A Houston; Leonard H Augenlicht; Barbara G Heerdt
Intrinsic mitochondrial membrane potential and associated tumor phenotype are independent of MUC1 over-expression.
PloS one 2011;6(9):e25207.
2011: Michele A Houston; Leonard H Augenlicht; Barbara G Heerdt
Stable differences in intrinsic mitochondrial membrane potential of tumor cell subpopulations reflect phenotypic heterogeneity.
International journal of cell biology 2011;2011():978583.
2010: Maria C Daroqui; Leonard H Augenlicht
Transcriptional attenuation in colon carcinoma cells in response to butyrate.
Cancer prevention research (Philadelphia, Pa.) 2010;3(10):1292-302.
2010: Raviraja N Seetharam; Arjun Sood; Atrayee Basu-Mallick; Leonard H Augenlicht; John M Mariadason; SANJAY GOEL
Oxaliplatin resistance induced by ERCC1 up-regulation is abrogated by siRNA-mediated gene silencing in human colorectal cancer cells.
Anticancer research 2010;30(7):2531-8.
2010: Donghai Wang; Rossanna C Pezo; Georgia Corner; Cristina Sison; Martin L Lesser; Shailesh M Shenoy; John M Mariadason; Robert H Singer; Leonard H Augenlicht
Altered dynamics of intestinal cell maturation in Apc1638N/+ mice.
Cancer research 2010;70(13):5348-57.
2010: Sandra Guilmeau; M Flandez; John M Mariadason; Leonard H Augenlicht
Heterogeneity of Jagged1 expression in human and mouse intestinal tumors: implications for targeting Notch signaling.
Oncogene 2010;29(7):992-1002.
2010: Lin Deng; Jin-Feng Zhou; Rani S Sellers; Jiu-Feng Li; Andrew V Nguyen; Yubao Wang; Amos Orlofsky; Qiang Liu; David A Hume; Jeffrey W Pollard; Leonard H Augenlicht; Elaine Y Lin
A novel mouse model of inflammatory bowel disease links mammalian target of rapamycin-dependent hyperproliferation of colonic epithelium to inflammation-associated tumorigenesis.
The American journal of pathology 2010;176(2):952-67.
2010: Andrew J Wilson; Anderly Chueh; Lars Tögel; Georgia A Corner; Naseem Ahmed; SANJAY GOEL; Do-Sun Byun; Shannon Nasser; Michele A Houston; Minaxi Jhawer; Helena J M Smartt; Lucas B Murray; Courtney Nicholas; Barbara G Heerdt; Diego Arango; Leonard H Augenlicht; John M Mariadason
Apoptotic sensitivity of colon cancer cells to histone deacetylase inhibitors is mediated by an Sp1/Sp3-activated transcriptional program involving immediate-early gene induction.
Cancer research 2010;70(2):609-20.
2010: Vishal N Patel; Gurkan Bebek; John M Mariadason; Donghai Wang; Leonard H Augenlicht; Mark R Chance
Prediction and testing of biological networks underlying intestinal cancer.
PloS one 2010;5(9):.
2010: Pawan Kaler; Vincent Galea; Leonard H Augenlicht; Lidija Klampfer
Tumor associated macrophages protect colon cancer cells from TRAIL-induced apoptosis through IL-1beta-dependent stabilization of Snail in tumor cells.
PloS one 2010;5(7):e11700.
2010: Ganepola A P Ganepola; Robert M Mazziotta; Dilendra Weeresinghe; Georgia A Corner; Cheryl J Parish; David H Chang; Niall C Tebbutt; Carmel Murone; Naseem Ahmed; Leonard H Augenlicht; John M Mariadason
Gene expression profiling of primary and metastatic colon cancers identifies a reduced proliferative rate in metastatic tumors.
Clinical & experimental metastasis 2010;27(1):1-9.
2009: P Kaler; Leonard H Augenlicht; Lidija Klampfer
Macrophage-derived IL-1beta stimulates Wnt signaling and growth of colon cancer cells: a crosstalk interrupted by vitamin D3.
Oncogene 2009;28(44):3892-902.
2009: Osamu Itano; Kan Yang; Kunhua Fan; Naoto Kurihara; Hiroharu Shinozaki; Sadanori Abe; Bo Jin; Claudia Gravaghi; Winfried Edelmann; Leonard H Augenlicht; Levy Kopelovich; Raju Kucherlapati; Sergio Lamprecht; Martin Lipkin
Sulindac effects on inflammation and tumorigenesis in the intestine of mice with Apc and Mlh1 mutations.
Carcinogenesis 2009;30(11):1923-6.
2009: Ziqiang Yuan; Joongho Shin; Andrew J Wilson; SANJAY GOEL; Yi-He Ling; Naseem Ahmed; Higinio Dopeso; Minaxi Jhawer; Shannon Nasser; Cristina Montagna; Kenneth Fordyce; Leonard H Augenlicht; Lauri A Aaltonen; Diego Arango; Thomas K. Weber; John M Mariadason
An A13 repeat within the 3'-untranslated region of epidermal growth factor receptor (EGFR) is frequently mutated in microsatellite instability colon cancers and is associated with increased EGFR expression.
Cancer research 2009;69(19):7811-8.
2009: Marybeth A Pysz; Olga V Leontieva; Nicholas W Bateman; Joshua M Uronis; Kathryn J Curry; David Threadgill; Klaus-Peter Janssen; Sylvie Robine; Anna Velcich; Leonard H Augenlicht; Adrian R Black; Jennifer D Black
PKCalpha tumor suppression in the intestine is associated with transcriptional and translational inhibition of cyclin D1.
Experimental cell research 2009;315(8):1415-28.
2009: Sandra Maier; M Cecilia Daroqui; Stefan Scherer; Stefan Roepcke; Anna Velcich; Shailesh M Shenoy; Robert H Singer; Leonard H Augenlicht
Butyrate and vitamin D3 induce transcriptional attenuation at the cyclin D1 locus in colonic carcinoma cells.
Journal of cellular physiology 2009;218(3):638-42.
2009: Petr Protiva; Heide S Cross; Michael E Hopkins; Enikö Kállay; Giovanna Bises; Eleanor Dreyhaupt; Leonard H Augenlicht; Martin Lipkin; Martin Lesser; Elayne Livote; Peter R Holt
Chemoprevention of colorectal neoplasia by estrogen: potential role of vitamin D activity.
Cancer prevention research (Philadelphia, Pa.) 2009;2(1):43-51.
2009: Harold L Newmark; Kan Yang; Naoto Kurihara; Kunhua Fan; Leonard H Augenlicht; Martin Lipkin
Western-style diet-induced colonic tumors and their modulation by calcium and vitamin D in C57Bl/6 mice: a preclinical model for human sporadic colon cancer.
Carcinogenesis 2009;30(1):88-92.
2008: M Flandez; Sandra Guilmeau; philippe blache; Leonard H Augenlicht
KLF4 regulation in intestinal epithelial cell maturation.
Experimental cell research 2008;314(20):3712-23.
2008: Jinsook Chang; Mark R Chance; Courtney Nicholas; Naseem Ahmed; Sandra Guilmeau; Marta Flandez; Donghai Wang; Do-Sun Byun; Shannon Nasser; Joseph M Albanese; Georgia A Corner; Barbara G Heerdt; Andrew J Wilson; Leonard H Augenlicht; John M Mariadason
Proteomic changes during intestinal cell maturation in vivo.
Journal of proteomics 2008;71(5):530-46.
2008: Tianhong Li; Wancai Yang; Maomi Li; Do-Sun Byun; Chang Tong; Shannon Nasser; Min Zhuang; Diego Arango; John M Mariadason; Leonard H Augenlicht
Expression of selenium-binding protein 1 characterizes intestinal cell maturation and predicts survival for patients with colorectal cancer.
Molecular nutrition & food research 2008;52(11):1289-99.
2008: Kan Yang; Naoto Kurihara; Kunhua Fan; Harold Newmark; Basil Rigas; Laura Bancroft; Georgia Corner; Elayne Livote; Martin Lesser; Winfried Edelmann; Anna Velcich; Martin Lipkin; Leonard H Augenlicht
Dietary induction of colonic tumors in a mouse model of sporadic colon cancer.
Cancer research 2008;68(19):7803-10.
2008: Andrew J Wilson; Do-Sun Byun; Shannon Nasser; Lucas B Murray; Kanyalakshmi Ayyanar; Diego Arango; Maria Figueroa; Ari Melnick; Gary D Kao; Leonard H Augenlicht; John M Mariadason
HDAC4 promotes growth of colon cancer cells via repression of p21.
Molecular biology of the cell 2008;19(10):4062-75.
2008: Kan Yang; Natalia V Popova; Wancai Yang; Ioanna Lozonschi; Selam Tadesse; Scott Kent; Laura Bancroft; Ilze Matise; Robert T Cormier; Stefan J Scherer; Winfried Edelmann; Martin Lipkin; Leonard H Augenlicht; Anna Velcich
Interaction of Muc2 and Apc on Wnt signaling and in intestinal tumorigenesis: potential role of chronic inflammation.
Cancer research 2008;68(18):7313-22.
2008: Kan Yang; Sergio A Lamprecht; Hiroharu Shinozaki; Kunhua Fan; Wancai Yang; Harold L Newmark; Levy Kopelovich; Winfried Edelmann; Bo Jin; Claudia Gravaghi; Leonard H Augenlicht; Raju Kucherlapati; Martin Lipkin
Dietary calcium and cholecalciferol modulate cyclin D1 expression, apoptosis, and tumorigenesis in intestine of adenomatous polyposis coli1638N/+ mice.
The Journal of nutrition 2008;138(9):1658-63.
2008: Sandra Guilmeau; Marta Flandez; Laura Bancroft; Rani S Sellers; Benjamin Tear; Pamela Stanley; Leonard H Augenlicht
Intestinal deletion of Pofut1 in the mouse inactivates notch signaling and causes enterocolitis.
Gastroenterology 2008;135(3):849-60, 860.e1-6.
2008: José M Escandell; Pawan Kaler; M Carmen Recio; Takehiko Sasazuki; Senji Shirasawa; Leonard H Augenlicht; José-Luis Ríos; Lidija Klampfer
Activated kRas protects colon cancer cells from cucurbitacin-induced apoptosis: the role of p53 and p21.
Biochemical pharmacology 2008;76(2):198-207.
2008: Rossanna C Pezo; Saumil J Gandhi; L Andrew Shirley; Richard G Pestell; Leonard H Augenlicht; Robert H Singer
Single-cell transcription site activation predicts chemotherapy response in human colorectal tumors.
Cancer research 2008;68(13):4977-82.
2008: Xiuli Bi; Chang Tong; Ashley Dockendorff; Laura Bancroft; Lindsay Gallagher; Grace Guzman-Hartman; Renato V Iozzo; Leonard H Augenlicht; Wancai Yang
Genetic deficiency of decorin causes intestinal tumor formation through disruption of intestinal cell maturation.
Carcinogenesis 2008;29(7):1435-40.
2008: Pawan Kaler; Takehiko Sasazuki; Senji Shirasawa; Leonard H Augenlicht; Lidija Klampfer
HDAC2 deficiency sensitizes colon cancer cells to TNFalpha-induced apoptosis through inhibition of NF-kappaB activity.
Experimental cell research 2008;314(7):1507-18.
2008: Anjia Han; Zibo Song; Chang Tong; Dong Hu; Xiuli Bi; Leonard H Augenlicht; Wancai Yang
Sulindac suppresses beta-catenin expression in human cancer cells.
European journal of pharmacology 2008;583(1):26-31.
2008: Minaxi Jhawer; SANJAY GOEL; Andrew J Wilson; Cristina Montagna; Yi-He Ling; Do-Sun Byun; Shannon Nasser; Diego Arango; Joongho Shin; Lidija Klampfer; Leonard H Augenlicht; Roman Perez-Soler; Roman Perez Soler; John M Mariadason
PIK3CA mutation/PTEN expression status predicts response of colon cancer cells to the epidermal growth factor receptor inhibitor cetuximab.
Cancer research 2008;68(6):1953-61.
2008: Luciana M Laguinge; Raed N Samara; Wenge Wang; Wafik S El-Deiry; Georgia A Corner; Leonard H Augenlicht; Lopa Mishra; J Milburn Jessup
DR5 receptor mediates anoikis in human colorectal carcinoma cell lines.
Cancer research 2008;68(3):909-17.
2007: Lidija Klampfer; Jie Huang; Senji Shirasawa; Takehiko Sasazuki; Leonard H Augenlicht
Histone deacetylase inhibitors induce cell death selectively in cells that harbor activated kRasV12: The role of signal transducers and activators of transcription 1 and p21.
Cancer research 2007;67(18):8477-85.
2007: Kan Yang; Martin Lipkin; Harold Newmark; Basil Rigas; Cecilia Daroqui; Sandra Maier; Leonard H Augenlicht
Molecular targets of calcium and vitamin D in mouse genetic models of intestinal cancer.
Nutrition reviews 2007;65(8 Pt 2):S134-7.
2007: Helena J M Smartt; Sandra Guilmeau; Shannon V Nasser; Courtney Nicholas; Laura Bancroft; Sharon A Simpson; Nancy Yeh; Wancai Yang; John M Mariadason; Andrew Koff; Leonard H Augenlicht
p27kip1 Regulates cdk2 activity in the proliferating zone of the mouse intestinal epithelium: potential role in neoplasia.
Gastroenterology 2007;133(1):232-43.
2007: Chang Tong; Zhinan Yin; Zibo Song; Ashley Dockendorff; Chuanshu Huang; John M Mariadason; Richard A Flavell; Roger J Davis; Leonard H Augenlicht; Wancai Yang
c-Jun NH2-terminal kinase 1 plays a critical role in intestinal homeostasis and tumor suppression.
The American journal of pathology 2007;171(1):297-303.
2007: Dineo Khabele; Deok-Soo Son; Angelika K Parl; Gary L Goldberg; Leonard H Augenlicht; John M Mariadason; Valerie Montgomery Rice
Drug-induced inactivation or gene silencing of class I histone deacetylases suppresses ovarian cancer cell growth: implications for therapy.
Cancer biology & therapy 2007;6(5):795-801.
2007: Zibo Song; Chang Tong; Jiao Liang; Ashley Dockendorff; Chuanshu Huang; Leonard H Augenlicht; Wancai Yang
JNK1 is required for sulindac-mediated inhibition of cell proliferation and induction of apoptosis in vitro and in vivo.
European journal of pharmacology 2007;560(2-3):95-100.
2007: Mateja Stempelj; Michèle Kedinger; Leonard H Augenlicht; Lidija Klampfer
Essential role of the JAK/STAT1 signaling pathway in the expression of inducible nitric-oxide synthase in intestinal epithelial cells and its regulation by butyrate.
The Journal of biological chemistry 2007;282(13):9797-804.
2007: Lidija Klampfer; Jie Huang; P Kaler; Takehiko Sasazuki; Senji Shirasawa; Leonard H Augenlicht
STAT1-independent inhibition of cyclooxygenase-2 expression by IFNgamma; a common pathway of IFNgamma-mediated gene repression but not gene activation.
Oncogene 2007;26(14):2071-81.
2006: Leonard H Augenlicht; Wancai Yang; John M Mariadason; Anna Velcich; Lidija Klampfer; Martin Lipkin; Kan Yang
Interaction of genetic and dietary factors in mouse intestinal tumorigenesis.
The Journal of nutrition 2006;136(10):2695S-6S.
2006: Andrew J Wilson; Do-Sun Byun; Natalia Popova; Lucas B Murray; Kaitlin L'Italien; Yoshihiro Sowa; Diego Arango; Anna Velcich; Leonard H Augenlicht; John M Mariadason
Histone deacetylase 3 (HDAC3) and other class I HDACs regulate colon cell maturation and p21 expression and are deregulated in human colon cancer.
The Journal of biological chemistry 2006;281(19):13548-58.
2006: Viktoriya Paroder; Shelly R Spencer; Monika Paroder; Diego Arango; Simo Schwartz; John M Mariadason; Leonard H Augenlicht; Sepehr Eskandari; Nancy Carrasco
Na(+)/monocarboxylate transport (SMCT) protein expression correlates with survival in colon cancer: molecular characterization of SMCT.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(19):7270-5.
2006: Barbara G Heerdt; Michele A Houston; Leonard H Augenlicht
Growth properties of colonic tumor cells are a function of the intrinsic mitochondrial membrane potential.
Cancer research 2006;66(3):1591-6.
2006: Anna Prokhortchouk; Owen J Sansom; Jim Selfridge; Isabel Martín Caballero; Sergey Salozhin; Dana Aithozhina; Leandro C A Cerchietti; Fan-Guo Meng; Leonard H Augenlicht; John M Mariadason; Brian Hendrich; Ari Melnick; Egor Prokhortchouk; Alan Clarke; Adrian Bird
Kaiso-deficient mice show resistance to intestinal cancer.
Molecular and cellular biology 2006;26(1):199-208.
2005: Leonard H Augenlicht
Pathways in nutritional modulation of homeostasis and tumorigenesis.
The Journal of nutrition 2005;135(12 Suppl):3025S-3026S.
2005: Barbara G Heerdt; Michele A Houston; Leonard H Augenlicht
The intrinsic mitochondrial membrane potential of colonic carcinoma cells is linked to the probability of tumor progression.
Cancer research 2005;65(21):9861-7.
2005: Kan Yang; Wancai Yang; John M Mariadason; Anna Velcich; Martin Lipkin; Leonard H Augenlicht
Dietary components modify gene expression: implications for carcinogenesis.
The Journal of nutrition 2005;135(11):2710-4.
2005: Wancai Yang; Laura Bancroft; Jiao Liang; Min Zhuang; Leonard H Augenlicht
p27kip1 in intestinal tumorigenesis and chemoprevention in the mouse.
Cancer research 2005;65(20):9363-8.
2005: Lidija Klampfer; Laurie-Anne Swaby; Jie Huang; Takehiko Sasazuki; Senji Shirasawa; Leonard H Augenlicht
Oncogenic Ras increases sensitivity of colon cancer cells to 5-FU-induced apoptosis.
Oncogene 2005;24(24):3932-41.
2005: John M Mariadason; Courtney Nicholas; Kaitlin E L'Italien; Min Zhuang; Helena J M Smartt; Barbara G Heerdt; Wancai Yang; Georgia A Corner; Andrew J Wilson; Lidija Klampfer; Diego Arango; Leonard H Augenlicht
Gene expression profiling of intestinal epithelial cell maturation along the crypt-villus axis.
Gastroenterology 2005;128(4):1081-8.
2005: Wancai Yang; Anna Velcich; Ioana Lozonschi; Jiao Liang; Courtney Nicholas; Min Zhuang; Laura Bancroft; Leonard H Augenlicht
Inactivation of p21WAF1/cip1 enhances intestinal tumor formation in Muc2-/- mice.
The American journal of pathology 2005;166(4):1239-46.
2005: Wancai Yang; Laura Bancroft; Leonard H Augenlicht
Methylation in the p21WAF1/cip1 promoter of Apc+/-, p21+/- mice and lack of response to sulindac.
Oncogene 2005;24(12):2104-9.
2005: Anna Velcich; Georgia A Corner; Doru Paul; Min Zhuang; John M Mariadason; Christian L Laboisse; Leonard H Augenlicht
Quantitative rather than qualitative differences in gene expression predominate in intestinal cell maturation along distinct cell lineages.
Experimental cell research 2005;304(1):28-39.
2004: Diego Arango; Andrew J Wilson; Quihu Shi; Georgia A Corner; M J Arañes; Courtney Nicholas; Martin Lesser; John M Mariadason; Leonard H Augenlicht
Molecular mechanisms of action and prediction of response to oxaliplatin in colorectal cancer cells.
British journal of cancer 2004;91(11):1931-46.
2004: James Hulit; Chenguang Wang; Zhiping Li; Chris Albanese; Mahadev Rao; Dolores Di Vizio; Salimuddin Shah; Stephen W Byers; Radma Mahmood; Leonard H Augenlicht; Robert Russell; Richard G Pestell
Cyclin D1 genetic heterozygosity regulates colonic epithelial cell differentiation and tumor number in ApcMin mice.
Molecular and cellular biology 2004;24(17):7598-611.
2004: Lidija Klampfer; Jie Huang; Takehiko Sasazuki; Senji Shirasawa; Leonard H Augenlicht
Oncogenic Ras promotes butyrate-induced apoptosis through inhibition of gelsolin expression.
The Journal of biological chemistry 2004;279(35):36680-8.
2004: Lidija Klampfer; Jie Huang; Laurie-Anne Swaby; Leonard H Augenlicht
Requirement of histone deacetylase activity for signaling by STAT1.
The Journal of biological chemistry 2004;279(29):30358-68.
2004: John M Mariadason; Diego Arango; Leonard H Augenlicht
Customizing chemotherapy for colon cancer: the potential of gene expression profiling.
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2004;7(3):209-18.
2004: Dineo Khabele; Melissa Lopez-Jones; Wancai Yang; Diego Arango; Susan J Gross; Leonard H Augenlicht; Gary L Goldberg
Tumor necrosis factor-alpha related gene response to Epothilone B in ovarian cancer.
Gynecologic oncology 2004;93(1):19-26.
2003: John M Mariadason; Diego Arango; Qiuhu Shi; Andrew J Wilson; Georgia A Corner; Courtney Nicholas; Maria J Aranes; Martin Lesser; Edward L Schwartz; Leonard H Augenlicht
Gene expression profiling-based prediction of response of colon carcinoma cells to 5-fluorouracil and camptothecin.
Cancer research 2003;63(24):8791-812.
2003: Lidija Klampfer; Jie Huang; Georgia A Corner; John M Mariadason; Diego Arango; Takehiko Sasazuki; Senji Shirasawa; Leonard H Augenlicht
Oncogenic Ki-ras inhibits the expression of interferon-responsive genes through inhibition of STAT1 and STAT2 expression.
The Journal of biological chemistry 2003;278(47):46278-87.
2003: Diego Arango; John M Mariadason; Andrew J Wilson; Wancai Yang; Georgia A Corner; Courtney Nicholas; M J Aranes; Leonard H Augenlicht
c-Myc overexpression sensitises colon cancer cells to camptothecin-induced apoptosis.
British journal of cancer 2003;89(9):1757-65.
2003: Theresa P Pretlow; Winfried Edelmann; Raju Kucherlapati; Thomas G Pretlow; Leonard H Augenlicht
Spontaneous aberrant crypt foci in Apc1638N mice with a mutant Apc allele.
The American journal of pathology 2003;163(5):1757-63.
2003: Barbara G Heerdt; Michele A Houston; Andrew J Wilson; Leonard H Augenlicht
The intrinsic mitochondrial membrane potential (Deltapsim) is associated with steady-state mitochondrial activity and the extent to which colonic epithelial cells undergo butyrate-mediated growth arrest and apoptosis.
Cancer research 2003;63(19):6311-9.
2003: Lidija Klampfer; Jie Huang; Takehiko Sasazuki; Senji Shirasawa; Leonard H Augenlicht
Inhibition of interferon gamma signaling by the short chain fatty acid butyrate.
Molecular cancer research : MCR 2003;1(11):855-62.
2003: Andrew J Wilson; Diego Arango; John M Mariadason; Barbara G Heerdt; Leonard H Augenlicht
TR3/Nur77 in colon cancer cell apoptosis.
Cancer research 2003;63(17):5401-7.
2003: Wancai Yang; Laura Bancroft; Courtney Nicholas; Ioana Lozonschi; Leonard H Augenlicht
Targeted inactivation of p27kip1 is sufficient for large and small intestinal tumorigenesis in the mouse, which can be augmented by a Western-style high-risk diet.
Cancer research 2003;63(16):4990-6.
2003: Leonard H Augenlicht; Li Shi; John M Mariadason; Christian L Laboisse; Anna Velcich
Repression of MUC2 gene expression by butyrate, a physiological regulator of intestinal cell maturation.
Oncogene 2003;22(32):4983-92.
2003: Yunfei Gao; Wancai Yang; Meng Pan; Eileen Scully; Michael Girardi; Leonard H Augenlicht; Joe Craft; Zhinan Yin
Gamma delta T cells provide an early source of interferon gamma in tumor immunity.
The Journal of experimental medicine 2003;198(3):433-42.
2003: Leonard H Augenlicht; Anna Velcich; Lidija Klampfer; Jie Huang; Georgia A Corner; Maria Aranes; Christian L Laboisse; Basil Rigas; Martin Lipkin; Kan Yang; Quihu Shi; Martin Lesser; Barbara G Heerdt; Diego Arango; Wancai Yang; Andrew J Wilson; John M Mariadason
Application of gene expression profiling to colon cell maturation, transformation and chemoprevention.
The Journal of nutrition 2003;133(7 Suppl):2410S-2416S.
2003: John M Mariadason; Leonard H Augenlicht; Diego Arango
Microarray analysis in the clinical management of cancer.
Hematology/oncology clinics of North America 2003;17(2):377-87.
2003: Kan Yang; Kunhua Fan; Naoto Kurihara; Hiroharu Shinozaki; Basil Rigas; Leonard H Augenlicht; Levy Kopelovich; Winfried Edelmann; Raju Kucherlapati; Martin Lipkin
Regional response leading to tumorigenesis after sulindac in small and large intestine of mice with Apc mutations.
Carcinogenesis 2003;24(3):605-11.
2002: Leonard H Augenlicht; John M Mariadason; Andrew J Wilson; Diego Arango; Wancai Yang; Barbara G Heerdt; Anna Velcich
Short chain fatty acids and colon cancer.
The Journal of nutrition 2002;132(12):3804S-3808S.
2002: Andrew J Wilson; Anna Velcich; Diego Arango; Amy R Kurland; Shailesh M Shenoy; Rossanna C Pezo; Jeffrey M. Levsky; Robert H Singer; Leonard H Augenlicht
Novel detection and differential utilization of a c-myc transcriptional block in colon cancer chemoprevention.
Cancer research 2002;62(21):6006-10.
2002: John M Mariadason; Diego Arango; Georgia A Corner; Maria J Arañes; Kylie A Hotchkiss; Wancai Yang; Leonard H Augenlicht
A gene expression profile that defines colon cell maturation in vitro.
Cancer research 2002;62(16):4791-804.
2002: Leonard H Augenlicht; Barbara G Heerdt; John M Mariadason; Wancai Yang; Andrew J Wilson; Alessandra Fragale; Anna Velcich
Environment-gene interactions in intestinal cancer.
European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) 2002;11 Suppl 2():S12-7.
2002: Anna Velcich; Wancai Yang; Joerg Heyer; Alessandra Fragale; Courtney Nicholas; Stephanie Viani; Raju Kucherlapati; Martin Lipkin; Kan Yang; Leonard H Augenlicht
Colorectal cancer in mice genetically deficient in the mucin Muc2.
Science (New York, N.Y.) 2002;295(5560):1726-9.
2002: Michael Bordonaro; Darina Lazarova; Leonard H Augenlicht; Alan C Sartorelli
Cell type- and promoter-dependent modulation of the Wnt signaling pathway by sodium butyrate.
International journal of cancer. Journal international du cancer 2002;97(1):42-51.
2001: Leonard H Augenlicht; S Wadler; Diego Arango
Clinical response to fluorouracil and p53.
The New England journal of medicine 2001;345(14):1065-6.
2001: Wancai Yang; Anna Velcich; John M Mariadason; Courtney Nicholas; Georgia A Corner; Michele A Houston; Winfried Edelmann; Raju Kucherlapati; P R Holt; Leonard H Augenlicht
p21(WAF1/cip1) is an important determinant of intestinal cell response to sulindac in vitro and in vivo.
Cancer research 2001;61(16):6297-302.
2001: Diego Arango; Georgia A Corner; Scott Wadler; Paul J Catalano; Leonard H Augenlicht
c-myc/p53 interaction determines sensitivity of human colon carcinoma cells to 5-fluorouracil in vitro and in vivo.
Cancer research 2001;61(12):4910-5.
2001: Leonard H Augenlicht; Barbara G Heerdt
Mitochondria: integrators in tumorigenesis?
Nature genetics 2001;28(2):104-5.
2001: John M Mariadason; Michael Bordonaro; F Aslam; L Shi; Mari Kuraguchi; Anna Velcich; Leonard H Augenlicht
Down-regulation of beta-catenin TCF signaling is linked to colonic epithelial cell differentiation.
Cancer research 2001;61(8):3465-71.
2001: John M Mariadason; Anna Velcich; Andrew J Wilson; Leonard H Augenlicht; Peter R Gibson
Resistance to butyrate-induced cell differentiation and apoptosis during spontaneous Caco-2 cell differentiation.
Gastroenterology 2001;120(4):889-99.
2001: F Aslam; L Palumbo; Leonard H Augenlicht; Anna Velcich
The Sp family of transcription factors in the regulation of the human and mouse MUC2 gene promoters.
Cancer research 2001;61(2):570-6.
2001: Wancai Yang; J Mathew; Anna Velcich; Winfried Edelmann; Raju Kucherlapati; Martin Lipkin; K Yang; Leonard H Augenlicht
Targeted inactivation of the p21(WAF1/cip1) gene enhances Apc-initiated tumor formation and the tumor-promoting activity of a Western-style high-risk diet by altering cell maturation in the intestinal mucosal.
Cancer research 2001;61(2):565-9.
2001: Brian T Zafonte; DF Amanatullah; D Sage; Leonard H Augenlicht; Richard G Pestell
Ras regulation of cyclin-dependent immunoprecipitation kinase assays.
Methods in enzymology 2001;333():127-38.
2000: Barbara G Heerdt; Michele A Houston; John M Mariadason; Leonard H Augenlicht
Dissociation of staurosporine-induced apoptosis from G2-M arrest in SW620 human colonic carcinoma cells: initiation of the apoptotic cascade is associated with elevation of the mitochondrial membrane potential (deltapsim).
Cancer research 2000;60(23):6704-13.
2000: Mark D'Amico; James Hulit; DF Amanatullah; Brian T Zafonte; Chris Albanese; Boumediene Bouzahzah; Maofu Fu; Leonard H Augenlicht; L A Donehower; K Takemaru; Randall T Moon; R Davis; Michael P Lisanti; Michael Shtutman; Jacob Zhurinsky; Avri Ben-Ze'ev; Armelle A Troussard; Shoukat Dedhar; Richard G Pestell
The integrin-linked kinase regulates the cyclin D1 gene through glycogen synthase kinase 3beta and cAMP-responsive element-binding protein-dependent pathways.
The Journal of biological chemistry 2000;275(42):32649-57.
2000: John M Mariadason; Georgia A Corner; Leonard H Augenlicht
Genetic reprogramming in pathways of colonic cell maturation induced by short chain fatty acids: comparison with trichostatin A, sulindac, and curcumin and implications for chemoprevention of colon cancer.
Cancer research 2000;60(16):4561-72.
2000: John M Mariadason; KL Rickard; DH Barkla; Leonard H Augenlicht; Peter R Gibson
Divergent phenotypic patterns and commitment to apoptosis of Caco-2 cells during spontaneous and butyrate-induced differentiation.
Journal of cellular physiology 2000;183(3):347-54.
1999: Leonard H Augenlicht; GM Anthony; T L Church; Winfried Edelmann; Raju Kucherlapati; K Yang; Martin Lipkin; Barbara G Heerdt
Short-chain fatty acid metabolism, apoptosis, and Apc-initiated tumorigenesis in the mouse gastrointestinal mucosa.
Cancer research 1999;59(23):6005-9.
1999: Leonard H Augenlicht
Correspondence re: N.N. Mahmoud et al., Genotype-phenotype correlation in murine Apc mutation: differences in enterocyte migration and response to sulindac. Cancer Res., 59: 353-359, 1999.
Cancer research 1999;59(22):5856-7.
1999: Michael Bordonaro; John M Mariadason; F Aslam; Barbara G Heerdt; Leonard H Augenlicht
Butyrate-induced apoptotic cascade in colonic carcinoma cells: modulation of the beta-catenin-Tcf pathway and concordance with effects of sulindac and trichostatin A but not curcumin.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1999;10(10):713-20.
1999: Anna Velcich; Georgia A Corner; L Palumbo; Leonard H Augenlicht
Altered phenotype of HT29 colonic adenocarcinoma cells following expression of the DCC gene.
Oncogene 1999;18(16):2599-606.
1999: Barbara G Heerdt; Michele A Houston; GM Anthony; Leonard H Augenlicht
Initiation of growth arrest and apoptosis of MCF-7 mammary carcinoma cells by tributyrin, a triglyceride analogue of the short-chain fatty acid butyrate, is associated with mitochondrial activity.
Cancer research 1999;59(7):1584-91.
1999: Leonard H Augenlicht; Anna Velcich; John M Mariadason; Michael Bordonaro; Barbara G Heerdt
Colonic cell proliferation, differentiation, and apoptosis.
Advances in experimental medicine and biology 1999;470():15-22.
1999: Leonard H Augenlicht; Michael Bordonaro; Barbara G Heerdt; John M Mariadason; Anna Velcich
Cellular mechanisms of risk and transformation.
Annals of the New York Academy of Sciences 1999;889():20-31.
1998: Barbara G Heerdt; Michele A Houston; GM Anthony; Leonard H Augenlicht
Mitochondrial membrane potential (delta psi(mt)) in the coordination of p53-independent proliferation and apoptosis pathways in human colonic carcinoma cells.
Cancer research 1998;58(13):2869-75.
1998: Leonard H Augenlicht
The molecular genetics of colonic cancer.
Cancer treatment and research 1998;98():351-82.
1997: Barbara G Heerdt; Michele A Houston; Leonard H Augenlicht
Short-chain fatty acid-initiated cell cycle arrest and apoptosis of colonic epithelial cells is linked to mitochondrial function.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1997;8(5):523-32.
1997: Leonard H Augenlicht; Scott Wadler; Georgia A Corner; C Richards; L Ryan; A S Multani; S Pathak; A Benson; D Haller; Barbara G Heerdt
Low-level c-myc amplification in human colonic carcinoma cell lines and tumors: a frequent, p53-independent mutation associated with improved outcome in a randomized multi-institutional trial.
Cancer research 1997;57(9):1769-75.
1997: Anna Velcich; L Palumbo; L Selleri; G Evans; Leonard H Augenlicht
Organization and regulatory aspects of the human intestinal mucin gene (MUC2) locus.
The Journal of biological chemistry 1997;272(12):7968-76.
1997: Michael Bordonaro; Leonard H Augenlicht
The 3' untranslated region of the carcinoembryonic antigen gene plays a minimal role in the regulation of gene expression.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1997;8(3):353-60.
1996: Leonard H Augenlicht; C Richards; Georgia A Corner; T P Pretlow
Evidence for genomic instability in human colonic aberrant crypt foci.
Oncogene 1996;12(8):1767-72.
1996: Barbara G Heerdt; Michele A Houston; J J Rediske; Leonard H Augenlicht
Steady-state levels of mitochondrial messenger RNA species characterize a predominant pathway culminating in apoptosis and shedding of HT29 human colonic carcinoma cells.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1996;7(1):101-06.
1995: J Chen; Barbara G Heerdt; Leonard H Augenlicht
Genetic chimerism.
Science (New York, N.Y.) 1995;268(5217):1552.
1995: Anna Velcich; L Palumbo; Anne Jarry; Christian L Laboisse; Janis Racevskis; Leonard H Augenlicht
Patterns of expression of lineage-specific markers during the in vitro-induced differentiation of HT29 colon carcinoma cells.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1995;6(6):749-57.
1995: J Chen; Barbara G Heerdt; Leonard H Augenlicht
Presence and instability of repetitive elements in sequences the altered expression of which characterizes risk for colonic cancer.
Cancer research 1995;55(1):174-80.
1995: Leonard H Augenlicht; Anna Velcich; Barbara G Heerdt
Short-chain fatty acids and molecular and cellular mechanisms of colonic cell differentiation and transformation.
Advances in experimental medicine and biology 1995;375():137-48.
1994: Leonard H Augenlicht
Adhesion molecules, cellular differentiation, and colonic crypt architecture.
Gastroenterology 1994;107(6):1894-8.
1994: Barbara G Heerdt; J Chen; L R Stewart; Leonard H Augenlicht
Polymorphisms, but lack of mutations or instability, in the promotor region of the mitochondrial genome in human colonic tumors.
Cancer research 1994;54(14):3912-5.
1994: Barbara G Heerdt; Michele A Houston; Leonard H Augenlicht
Potentiation by specific short-chain fatty acids of differentiation and apoptosis in human colonic carcinoma cell lines.
Cancer research 1994;54(12):3288-93.
1994: Anne Jarry; D Merlin; Anna Velcich; Ulrich Hopfer; Leonard H Augenlicht; Christian L Laboisse
Interferon-gamma modulates cAMP-induced mucin exocytosis without affecting mucin gene expression in a human colonic goblet cell line.
European journal of pharmacology 1994;267(1):95-103.
1993: Anna Velcich; Leonard H Augenlicht
Regulated expression of an intestinal mucin gene in HT29 colonic carcinoma cells.
The Journal of biological chemistry 1993;268(19):13956-61.
1992: Leonard H Augenlicht
Gene structure, function, and abnormalities.
Cancer 1992;70(6 Suppl):1671-84.
1992: Leonard H Augenlicht; Barbara G Heerdt
Modulation of gene expression as a biomarker in colon.
Journal of cellular biochemistry. Supplement 1992;16G():151-7.
1991: Barbara G Heerdt; Leonard H Augenlicht
Effects of fatty acids on expression of genes encoding subunits of cytochrome c oxidase and cytochrome c oxidase activity in HT29 human colonic adenocarcinoma cells.
The Journal of biological chemistry 1991;266(28):19120-6.
1991: Leonard H Augenlicht; J Taylor; L Anderson; M Lipkin
Patterns of gene expression that characterize the colonic mucosa in patients at genetic risk for colonic cancer.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(8):3286-9.
1991: Barbara G Heerdt; S Molinas; D Deitch; Leonard H Augenlicht
Aggressive subtypes of human colorectal tumors frequently exhibit amplification of the c-myc gene.
Oncogene 1991;6(1):125-9.
1990: Barbara G Heerdt; H K Halsey; M Lipkin; Leonard H Augenlicht
Expression of mitochondrial cytochrome c oxidase in human colonic cell differentiation, transformation, and risk for colonic cancer.
Cancer research 1990;50(5):1596-600.
1990: Barbara G Heerdt; Leonard H Augenlicht
Absence of detectable deletions in the mitochondrial genome of human colon tumors.
Cancer communications 1990;2(3):109-11.
1990: Barbara G Heerdt; Leonard H Augenlicht
Changes in the number of mitochondrial genomes during human development.
Experimental cell research 1990;186(1):54-9.
1989: E S Athan; Elisabeth Paietta; P R Papenhausen; Leonard H Augenlicht; Peter H Wiernik; Robert E Gallagher
Stability of multiple antigen receptor gene rearrangements and immunophenotype in Hodgkin's disease-derived cell line L428 and variant subline L428KSA.
Leukemia 1989;3(7):505-10.
1988: Leonard H Augenlicht
Gene expression in human colonic biopsies.
Progress in clinical and biological research 1988;279():195-202.
1987: Leonard H Augenlicht; M Z Wahrman; H Halsey; L Anderson; J Taylor; M Lipkin
Expression of cloned sequences in biopsies of human colonic tissue and in colonic carcinoma cells induced to differentiate in vitro.
Cancer research 1987;47(22):6017-21.
1987: Leonard H Augenlicht; C Augeron; G Yander; Christian L Laboisse
Overexpression of ras in mucus-secreting human colon carcinoma cells of low tumorigenicity.
Cancer research 1987;47(14):3763-5.
1985: G Yander; H Halsey; M Kenna; Leonard H Augenlicht
Amplification and elevated expression of c-myc in a chemically induced mouse colon tumor.
Cancer research 1985;45(9):4433-8.
1985: Leonard H Augenlicht; H Halsey
Expression of a mouse long terminal repeat is cell cycle-linked.
Proceedings of the National Academy of Sciences of the United States of America 1985;82(7):1946-9.
1985: M Z Wahrman; S E Gagnier; D R Kobrin; P J Higgins; Leonard H Augenlicht
Cellular and molecular changes in 3T3 cells transformed spontaneously or by DNA transfection.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 1985;6(1):41-56.
1984: Leonard H Augenlicht; D Kobrin; A Pavlovec; M E Royston
Elevated expression of an endogenous retroviral long terminal repeat in a mouse colon tumor.
The Journal of biological chemistry 1984;259(3):1842-7.
1984: M Z Wahrman; Leonard H Augenlicht; P J Higgins
Alterations in growth properties and cellular proteins of cloned hamster lung fibroblasts during long-term culture.
Oncology 1984;41(1):49-54.
1983: M E Royston; Leonard H Augenlicht
Biotinated probe containing a long-terminal repeat hybridized to a mouse colon tumor and normal tissue.
Science (New York, N.Y.) 1983;222(4630):1339-41.
1982: Leonard H Augenlicht; D Kobrin
Cloning and screening of sequences expressed in a mouse colon tumor.
Cancer research 1982;42(3):1088-93.
1982: M Usugane; M Fujita; M Lipkin; R Palmer; E Friedman; Leonard H Augenlicht
Cell proliferation in explant cultures of human colon.
Digestion 1982;24(4):225-33.
1979: Leonard H Augenlicht
Protected nucleotide sequences in nuclear ribonucleoprotein.
Biochemistry 1979;18(17):3780-6.
1979: M Z Wahrman; Leonard H Augenlicht
Limited nuclease digestion of heterogeneous nuclear ribonucleoprotein in nuclei.
Biochemical and biophysical research communications 1979;87(2):395-402.
1978: Leonard H Augenlicht
Staphylococcal nuclease digestion of relatively stable RNA in the chromatin and nuclear ribonucleoprotein fractions of human carcinoma cells.
The Journal of biological chemistry 1978;253(9):3035-41.
1977: Leonard H Augenlicht; M Lipkin
Serum stimulation of human fibroblasts: effect on non-histones of nuclear ribonucleoprotein and chromatin.
Journal of cellular physiology 1977;92(1):129-35.
1977: Leonard H Augenlicht
Nuclease digestion of RNA in chromatin.
Methods in cell biology 1977;16():467-72.
1976: Leonard H Augenlicht; M McCormick; M Lipkin
Digestion of RNA of chromatin and nuclear ribonucleoprotein by staphylococcal nuclease.
Biochemistry 1976;15(17):3818-23.
1976: Leonard H Augenlicht; M Lipkin
Chromatin monomer: absence of non-histone proteins.
Biochemical and biophysical research communications 1976;70(2):540-4.
1976: Leonard H Augenlicht; M Lipkin
Appearance of rapidly labeled, high molecular weight RNA in nuclear ribonucleoprotein. Release from chromatin and association with protein.
The Journal of biological chemistry 1976;251(9):2592-9.
1975: Leonard H Augenlicht; H Biessmann; M F Rajewsky
Chromosomal proteins of rat brain: increased synthesis and affinity for DNA following a pulse of the carcinogen ethyinitrosourea in vivo.
Journal of cellular physiology 1975;86(2 PT 2 SUPPL 1):431-8.
1975: Leonard H Augenlicht; T S Argyris
Stimulation of immature male rat liver growth by phenobarbital and 3-methylcholanthrene.
Experimental and molecular pathology 1975;22(1):1-10.
1974: Leonard H Augenlicht; R Baserga
Changes in the G0 state of WI-38 fibroblasts at different times after confluence.
Experimental cell research 1974;89(2):255-62.
1974: Leonard H Augenlicht; C Nicolini; R Baserga
Circular dichroism and thermal denaturation studies of chromatin and DNA from BrdU-treated mouse fibroblasts.
Biochemical and biophysical research communications 1974;59(3):920-6.
1973: B T Hill; Leonard H Augenlicht; R Baserga
Increased incorporation of 5-bromodeoxyuridine into the DNA of proliferating tissues in partially hepatectomised mice.
FEBS letters 1973;37(2):298-302.
1973: Leonard H Augenlicht; R Baserga
Nonhistone chromosomal proteins in control of cell division.
Transplantation proceedings 1973;5(3):1177-80.
1973: Leonard H Augenlicht; R Baserga
Preparation and partial fractionation of nonhistone chromosomal proteins from human diploid fibroblasts.
Archives of biochemistry and biophysics 1973;158(1):89-96.