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Sandra Hufeisen

Research Profile

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Michael J Keiser; Vincent Setola; John J Irwin; Christian Laggner; Atheir I Abbas; Sandra J Hufeisen; Niels H Jensen; Michael B Kuijer; Roberto C Matos; Thuy B Tran; Ryan Whaley; Richard A Glennon; Jérôme Hert; Kelan L H Thomas; Douglas D Edwards; Brian Shoichet; Bryan L Roth
Predicting new molecular targets for known drugs.
Douglas J Sheffler; Wesley K Kroeze; Bonnie G Garcia; Ariel Deutch; Sandra J Hufeisen; Patrick Leahy; Jens C Brüning; Bryan L Roth
p90 ribosomal S6 kinase 2 exerts a tonic brake on G protein-coupled receptor signaling.
Marilyn A Davies; Vincent Setola; R T Strachan; Douglas J Sheffler; E Salay; Sandra J Hufeisen; Bryan L Roth
Pharmacologic analysis of non-synonymous coding h5-HT2A SNPs reveals alterations in atypical antipsychotic and agonist efficacies.

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All Publications

2009: Michael J Keiser; Vincent Setola; John J Irwin; Christian Laggner; Atheir I Abbas; Sandra J Hufeisen; Niels H Jensen; Michael B Kuijer; Roberto C Matos; Thuy B Tran; Ryan Whaley; Richard A Glennon; Jérôme Hert; Kelan L H Thomas; Douglas D Edwards; Brian Shoichet; Bryan L Roth
Predicting new molecular targets for known drugs.
Nature 2009;462(7270):175-81.
2006: Douglas J Sheffler; Wesley K Kroeze; Bonnie G Garcia; Ariel Deutch; Sandra J Hufeisen; Patrick Leahy; Jens C Brüning; Bryan L Roth
p90 ribosomal S6 kinase 2 exerts a tonic brake on G protein-coupled receptor signaling.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(12):4717-22.
2006: Marilyn A Davies; Vincent Setola; R T Strachan; Douglas J Sheffler; E Salay; Sandra J Hufeisen; Bryan L Roth
Pharmacologic analysis of non-synonymous coding h5-HT2A SNPs reveals alterations in atypical antipsychotic and agonist efficacies.
The pharmacogenomics journal 2006;6(1):42-51.
2005: Marilyn A Davies; Beth A Compton-Toth; Sandra J Hufeisen; Herbert Y Meltzer; Bryan L Roth
The highly efficacious actions of N-desmethylclozapine at muscarinic receptors are unique and not a common property of either typical or atypical antipsychotic drugs: is M1 agonism a pre-requisite for mimicking clozapine's actions?
Psychopharmacology 2005;178(4):451-60.
2004: Charles Chavkin; Sumit Sud; Wenzhen Jin; Jeremy Stewart; Jordan K Zjawiony; Daniel J Siebert; Beth Ann Toth; Sandra J Hufeisen; Bryan L Roth
Salvinorin A, an active component of the hallucinogenic sage salvia divinorum is a highly efficacious kappa-opioid receptor agonist: structural and functional considerations.
The Journal of pharmacology and experimental therapeutics 2004;308(3):1197-203.
2003: Qi Shi; Sandra J Hufeisen; Jarda T Wroblewski; Joseph H Nadeau; Bryan L Roth
L-homocysteine sulfinic acid and L-homocysteic acid stimulate phosphoinositide hydrolysis in rat cortical neurons.
Annals of the New York Academy of Sciences 2003;1003():461-3.
2003: Richard B Rothman; Nga Vu; John S Partilla; Bryan L Roth; Sandra J Hufeisen; Beth A Compton-Toth; Jon Birkes; Richard Young; Richard A Glennon
In vitro characterization of ephedrine-related stereoisomers at biogenic amine transporters and the receptorome reveals selective actions as norepinephrine transporter substrates.
The Journal of pharmacology and experimental therapeutics 2003;307(1):138-45.
2003: Vincent Setola; Sandra J Hufeisen; K Jane Grande-Allen; Ivan Vesely; Richard A Glennon; Bruce Blough; Richard B Rothman; Bryan L Roth
3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") induces fenfluramine-like proliferative actions on human cardiac valvular interstitial cells in vitro.
Molecular pharmacology 2003;63(6):1223-9.
2003: Qi Shi; Jason E Savage; Sandra J Hufeisen; Laura Rauser; Ewa Grajkowska; Paul Ernsberger; Jarda T Wroblewski; Joseph H Nadeau; Bryan L Roth
L-homocysteine sulfinic acid and other acidic homocysteine derivatives are potent and selective metabotropic glutamate receptor agonists.
The Journal of pharmacology and experimental therapeutics 2003;305(1):131-42.
2003: Wesley K Kroeze; Sandra J Hufeisen; Beth A Popadak; Sean Renock; SeAnna Steinberg; Paul Ernsberger; Karu Jayathilake; Herbert Y Meltzer; Bryan L Roth
H1-histamine receptor affinity predicts short-term weight gain for typical and atypical antipsychotic drugs.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2003;28(3):519-26.
2003: Zongqi Xia; Sandra J Hufeisen; John A Gray; Bryan L Roth
The PDZ-binding domain is essential for the dendritic targeting of 5-HT2A serotonin receptors in cortical pyramidal neurons in vitro.
Neuroscience 2003;122(4):907-20.
2002: Veronika Butterweck; Adolf Nahrstedt; Jon Evans; Sandra J Hufeisen; Laura Rauser; Jason Savage; Beth Popadak; Paul Ernsberger; Bryan L Roth
In vitro receptor screening of pure constituents of St. John's wort reveals novel interactions with a number of GPCRs.
Psychopharmacology 2002;162(2):193-202.
2001: John A Gray; Douglas J Sheffler; Anushree Bhatnagar; J A Woods; Sandra J Hufeisen; JL Benovic; Bryan L Roth
Cell-type specific effects of endocytosis inhibitors on 5-hydroxytryptamine(2A) receptor desensitization and resensitization reveal an arrestin-, GRK2-, and GRK5-independent mode of regulation in human embryonic kidney 293 cells.
Molecular pharmacology 2001;60(5):1020-30.
2001: Bryan L Roth; Paul Ernsberger; S A Steinberg; S Rao; Laura Rauser; Jason Savage; Sandra J Hufeisen; Marc S Berridge; Raymond F Muzic
The in vitro pharmacology of the beta-adrenergic receptor pet ligand (s)-fluorocarazolol reveals high affinity for cloned beta-adrenergic receptors and moderate affinity for the human 5-HT1A receptor.
Psychopharmacology 2001;157(1):111-4.
2000: Richard B Rothman; Michael H Baumann; Jason E Savage; Laura Rauser; A McBride; Sandra J Hufeisen; Bryan L Roth
Evidence for possible involvement of 5-HT(2B) receptors in the cardiac valvulopathy associated with fenfluramine and other serotonergic medications.
Circulation 2000;102(23):2836-41.
2000: Richard A Glennon; Mase Lee; Jagadeesh B Rangisetty; Malgorzata Dukat; Bryan L Roth; Jason E Savage; A McBride; Laura Rauser; Sandra J Hufeisen; DK Lee
2-Substituted tryptamines: agents with selectivity for 5-HT(6) serotonin receptors.
Journal of medicinal chemistry 2000;43(5):1011-8.