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Colin Hughes

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Chemicals & Drugs

Living Beings

Concepts & Ideas

Molecular Sequence Data

Anatomy

Flagella

Genes & Molecular Sequences

Physiology

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Co-Publications
Name
46
Koronakis, Vassilis
20
Koronakis, Eva
9
Fraser, Gillian
8
Gygi, D
6
Bokma, Evert
6
Eswaran, Jeyanthy
4
Claret, Laurent
4
Stafford, Graham
3
Hardie, Kim
3
Hay, NA
3
Higgins, Matthew
3
Evans, Lewis
3
Furness, Richard
3
Bennett, JC
2
Lobedanz, Sune

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Publications

TOP 3
Symmons Martyn F; Bokma Evert; Koronakis Eva; Hughes Colin; Koronakis Vassilis
The assembled structure of a complete tripartite bacterial multidrug efflux pump.
Evans Lewis D B; Hughes Colin
Selective binding of virulence type III export chaperones by FliJ escort orthologues InvI and YscO.
Stafford Graham P; Evans Lewis D B; Krumscheid Rita; Dhillon Paraminder; Fraser Gillian M; Hughes Colin
Sorting of early and late flagellar subunits after docking at the membrane ATPase of the type III export pathway.

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All Publications

2009: Symmons Martyn F; Bokma Evert; Koronakis Eva; Hughes Colin; Koronakis Vassilis
The assembled structure of a complete tripartite bacterial multidrug efflux pump.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(17):7173-8.
2009: Evans Lewis D B; Hughes Colin
Selective binding of virulence type III export chaperones by FliJ escort orthologues InvI and YscO.
FEMS microbiology letters 2009;293(2):292-7.
2007: Stafford Graham P; Evans Lewis D B; Krumscheid Rita; Dhillon Paraminder; Fraser Gillian M; Hughes Colin
Sorting of early and late flagellar subunits after docking at the membrane ATPase of the type III export pathway.
Journal of molecular biology 2007;374(4):877-82.
2007: Lobedanz Sune; Bokma Evert; Symmons Martyn F; Koronakis Eva; Hughes Colin; Koronakis Vassilis
A periplasmic coiled-coil interface underlying TolC recruitment and the assembly of bacterial drug efflux pumps.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(11):4612-7.
2007: Stafford Graham P; Hughes Colin
Salmonella typhimurium flhE, a conserved flagellar regulon gene required for swarming.
Microbiology (Reading, England) 2007;153(Pt 2):541-7.
2006: Evans Lewis D B; Stafford Graham P; Ahmed Sangita; Fraser Gillian M; Hughes Colin
An escort mechanism for cycling of export chaperones during flagellum assembly.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(46):17474-9.
2006: Bokma Evert; Koronakis Eva; Lobedanz Sune; Hughes Colin; Koronakis Vassilis
Directed evolution of a bacterial efflux pump: adaptation of the E. coli TolC exit duct to the Pseudomonas MexAB translocase.
FEBS letters 2006;580(22):5339-43.
2005: Stafford Graham P; Ogi Tomoo; Hughes Colin
Binding and transcriptional activation of non-flagellar genes by the Escherichia coli flagellar master regulator FlhD2C2.
Microbiology (Reading, England) 2005;151(Pt 6):1779-88.
2004: Eswaran Jeyanthy; Koronakis Eva; Higgins Matthew K; Hughes Colin; Koronakis Vassilis
Three's company: component structures bring a closer view of tripartite drug efflux pumps.
Current opinion in structural biology 2004;14(6):741-7.
2004: Higgins Matthew K; Eswaran Jeyanthy; Edwards Patricia; Schertler Gebhard F X; Hughes Colin; Koronakis Vassilis
Structure of the ligand-blocked periplasmic entrance of the bacterial multidrug efflux protein TolC.
Journal of molecular biology 2004;342(3):697-702.
2004: Touzé Thierry; Eswaran Jeyanthy; Bokma Evert; Koronakis Eva; Hughes Colin; Koronakis Vassilis
Interactions underlying assembly of the Escherichia coli AcrAB-TolC multidrug efflux system.
Molecular microbiology 2004;53(2):697-706.
2004: Higgins Matthew K; Bokma Evert; Koronakis Eva; Hughes Colin; Koronakis Vassilis
Structure of the periplasmic component of a bacterial drug efflux pump.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(27):9994-9.
2004: Thomas Joanne; Stafford Graham P; Hughes Colin
Docking of cytosolic chaperone-substrate complexes at the membrane ATPase during flagellar type III protein export.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(11):3945-50.
2004: Koronakis Vassilis; Eswaran Jeyanthy; Hughes Colin
Structure and function of TolC: the bacterial exit duct for proteins and drugs.
Annual review of biochemistry 2004;73():467-89.
2003: Eswaran Jeyanthy; Hughes Colin; Koronakis Vassilis
Locking TolC entrance helices to prevent protein translocation by the bacterial type I export apparatus.
Journal of molecular biology 2003;327(2):309-15.
2003: Ozin Amanda J; Claret Laurent; Auvray Frederic; Hughes Colin
The FliS chaperone selectively binds the disordered flagellin C-terminal D0 domain central to polymerisation.
FEMS microbiology letters 2003;219(2):219-24.
2002: Andersen Christian; Koronakis Eva; Bokma Evert; Eswaran Jeyanthy; Humphreys Daniel; Hughes Colin; Koronakis Vassilis
Transition to the open state of the TolC periplasmic tunnel entrance.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(17):11103-8.
2002: Claret Laurent; Hughes Colin
Interaction of the atypical prokaryotic transcription activator FlhD2C2 with early promoters of the flagellar gene hierarchy.
Journal of molecular biology 2002;321(2):185-99.
2002: Fraser Gillian M; Claret Laurent; Furness Richard; Gupta Srishti; Hughes Colin
Swarming-coupled expression of the Proteus mirabilis hpmBA haemolysin operon.
Microbiology (Reading, England) 2002;148(Pt 7):2191-201.
2002: Andersen Christian; Koronakis Eva; Hughes Colin; Koronakis Vassilis
An aspartate ring at the TolC tunnel entrance determines ion selectivity and presents a target for blocking by large cations.
Molecular microbiology 2002;44(5):1131-9.
2002: Auvray Frédéric; Ozin Amanda J; Claret Laurent; Hughes Colin
Intrinsic membrane targeting of the flagellar export ATPase FliI: interaction with acidic phospholipids and FliH.
Journal of molecular biology 2002;318(4):941-50.
2001: Balakrishnan L; Hughes C; Koronakis V
Substrate-triggered recruitment of the TolC channel-tunnel during type I export of hemolysin by Escherichia coli.
Journal of molecular biology 2001;313(3):501-10.
2001: Hyland C; Vuillard L; Hughes C; Koronakis V
Membrane interaction of Escherichia coli hemolysin: flotation and insertion-dependent labeling by phospholipid vesicles.
Journal of bacteriology 2001;183(18):5364-70.
2001: Koronakis V; Andersen C; Hughes C
Channel-tunnels.
Current opinion in structural biology 2001;11(4):403-7.
2001: Auvray F; Thomas J; Fraser G M; Hughes C
Flagellin polymerisation control by a cytosolic export chaperone.
Journal of molecular biology 2001;308(2):221-9.
2001: Bennett J C; Thomas J; Fraser G M; Hughes C
Substrate complexes and domain organization of the Salmonella flagellar export chaperones FlgN and FliT.
Molecular microbiology 2001;39(3):781-91.
2000: Claret L; Hughes C
Functions of the subunits in the FlhD(2)C(2) transcriptional master regulator of bacterial flagellum biogenesis and swarming.
Journal of molecular biology 2000;303(4):467-78.
2000: Koronakis V; Sharff A; Koronakis E; Luisi B; Hughes C
Crystal structure of the bacterial membrane protein TolC central to multidrug efflux and protein export.
Nature 2000;405(6789):914-9.
2000: Bennett J C; Hughes C
From flagellum assembly to virulence: the extended family of type III export chaperones.
Trends in microbiology 2000;8(5):202-4.
2000: Claret L; Hughes C
Rapid turnover of FlhD and FlhC, the flagellar regulon transcriptional activator proteins, during Proteus swarming.
Journal of bacteriology 2000;182(3):833-6.
2000: Bailey M J; Hughes C; Koronakis V
In vitro recruitment of the RfaH regulatory protein into a specialised transcription complex, directed by the nucleic acid ops element.
Molecular & general genetics : MGG 2000;262(6):1052-9.
1999: Fraser G M; Hughes C
Swarming motility.
Current opinion in microbiology 1999;2(6):630-5.
1999: Stanley P; Hyland C; Koronakis V; Hughes C
An ordered reaction mechanism for bacterial toxin acylation by the specialized acyltransferase HlyC: formation of a ternary complex with acylACP and protoxin substrates.
Molecular microbiology 1999;34(5):887-901.
1999: Fraser G M; Bennett J C; Hughes C
Substrate-specific binding of hook-associated proteins by FlgN and FliT, putative chaperones for flagellum assembly.
Molecular microbiology 1999;32(3):569-80.
1999: Hay N A; Tipper D J; Gygi D; Hughes C
A novel membrane protein influencing cell shape and multicellular swarming of Proteus mirabilis.
Journal of bacteriology 1999;181(7):2008-16.
1998: Thanabalu T; Koronakis E; Hughes C; Koronakis V
Substrate-induced assembly of a contiguous channel for protein export from E.coli: reversible bridging of an inner-membrane translocase to an outer membrane exit pore.
The EMBO journal 1998;17(22):6487-96.
1998: Dufour A; Furness R B; Hughes C
Novel genes that upregulate the Proteus mirabilis flhDC master operon controlling flagellar biogenesis and swarming.
Molecular microbiology 1998;29(3):741-51.
1998: Lai H C; Gygi D; Fraser G M; Hughes C
A swarming-defective mutant of Proteus mirabilis lacking a putative cation-transporting membrane P-type ATPase.
Microbiology (Reading, England) 1998;144 ( Pt 7)():1957-61.
1998: Stanley P; Koronakis V; Hughes C
Acylation of Escherichia coli hemolysin: a unique protein lipidation mechanism underlying toxin function.
Microbiology and molecular biology reviews : MMBR 1998;62(2):309-33.
1998: Wong K R; Hughes C; Koronakis V
A gene, yaeQ, that suppresses reduced operon expression caused by mutations in the transcription elongation gene rfaH in Escherichia coli and Salmonella typhimurium.
Molecular & general genetics : MGG 1998;257(6):693-6.
1997: Bailey M J; Hughes C; Koronakis V
RfaH and the ops element, components of a novel system controlling bacterial transcription elongation.
Molecular microbiology 1997;26(5):845-51.
1997: Furness R B; Fraser G M; Hay N A; Hughes C
Negative feedback from a Proteus class II flagellum export defect to the flhDC master operon controlling cell division and flagellum assembly.
Journal of bacteriology 1997;179(17):5585-8.
1997: Gygi D; Fraser G; Dufour A; Hughes C
A motile but non-swarming mutant of Proteus mirabilis lacks FlgN, a facilitator of flagella filament assembly.
Molecular microbiology 1997;25(3):597-604.
1997: Hay N A; Tipper D J; Gygi D; Hughes C
A nonswarming mutant of Proteus mirabilis lacks the Lrp global transcriptional regulator.
Journal of bacteriology 1997;179(15):4741-6.
1997: Gaisser S; Hughes C
A locus coding for putative non-ribosomal peptide/polyketide synthase functions is mutated in a swarming-defective Proteus mirabilis strain.
Molecular & general genetics : MGG 1997;253(4):415-27.
1996: Bailey M J; Hughes C; Koronakis V
Increased distal gene transcription by the elongation factor RfaH, a specialized homologue of NusG.
Molecular microbiology 1996;22(4):729-37.
1996: Koronakis V; Hughes C
Synthesis, maturation and export of the E. coli hemolysin.
Medical microbiology and immunology 1996;185(2):65-71.
1996: Stanley P; Koronakis V; Hardie K; Hughes C
Independent interaction of the acyltransferase HlyC with two maturation domains of the Escherichia coli toxin HlyA.
Molecular microbiology 1996;20(4):813-22.
1996: Nieto J M; Bailey M J; Hughes C; Koronakis V
Suppression of transcription polarity in the Escherichia coli haemolysin operon by a short upstream element shared by polysaccharide and DNA transfer determinants.
Molecular microbiology 1996;19(4):705-13.
1995: Gygi D; Rahman M M; Lai H C; Carlson R; Guard-Petter J; Hughes C
A cell-surface polysaccharide that facilitates rapid population migration by differentiated swarm cells of Proteus mirabilis.
Molecular microbiology 1995;17(6):1167-75.
1995: Koronakis E; Hughes C; Milisav I; Koronakis V
Protein exporter function and in vitro ATPase activity are correlated in ABC-domain mutants of HlyB.
Molecular microbiology 1995;16(1):87-96.
1995: Gygi D; Bailey M J; Allison C; Hughes C
Requirement for FlhA in flagella assembly and swarm-cell differentiation by Proteus mirabilis.
Molecular microbiology 1995;15(4):761-9.
1994: Stanley P; Packman L C; Koronakis V; Hughes C
Fatty acylation of two internal lysine residues required for the toxic activity of Escherichia coli hemolysin.
Science (New York, N.Y.) 1994;266(5193):1992-6.
1994: Allison C; Emödy L; Coleman N; Hughes C
The role of swarm cell differentiation and multicellular migration in the uropathogenicity of Proteus mirabilis.
The Journal of infectious diseases 1994;169(5):1155-8.
1993: Milisav-Ribaric I; Hughes C; Koronakis E; Koronakis V
ATPase activity and ATP/ADP-induced conformational change in the bacterial toxin exporter hemolysin B.
Biochemical Society transactions 1993;21(4):347S.
1993: Stanley P L; Diaz P; Bailey M J; Gygi D; Juarez A; Hughes C
Loss of activity in the secreted form of Escherichia coli haemolysin caused by an rfaP lesion in core lipopolysaccharide assembly.
Molecular microbiology 1993;10(4):781-7.
1993: Koronakis V; Hughes C; Koronakis E
ATPase activity and ATP/ADP-induced conformational change in the soluble domain of the bacterial protein translocator HlyB.
Molecular microbiology 1993;8(6):1163-75.
1993: Allison C; Lai H C; Gygi D; Hughes C
Cell differentiation of Proteus mirabilis is initiated by glutamine, a specific chemoattractant for swarming cells.
Molecular microbiology 1993;8(1):53-60.
1993: Koronakis V; Hughes C
Bacterial signal peptide-independent protein export: HlyB-directed secretion of hemolysin.
Seminars in cell biology 1993;4(1):7-15.
1992: Allison C; Coleman N; Jones P L; Hughes C
Ability of Proteus mirabilis to invade human urothelial cells is coupled to motility and swarming differentiation.
Infection and immunity 1992;60(11):4740-6.
1992: Koronakis V; Stanley P; Koronakis E; Hughes C
The HlyB/HlyD-dependent secretion of toxins by gram-negative bacteria.
FEMS microbiology immunology 1992;5(1-3):45-53.
1992: Hughes C; Issartel J P; Hardie K; Stanley P; Koronakis E; Koronakis V
Activation of Escherichia coli prohemolysin to the membrane-targetted toxin by HlyC-directed ACP-dependent fatty acylation.
FEMS microbiology immunology 1992;5(1-3):37-43.
1992: Hughes C; Stanley P; Koronakis V
E. coli hemolysin interactions with prokaryotic and eukaryotic cell membranes.
BioEssays : news and reviews in molecular, cellular and developmental biology 1992;14(8):519-25.
1992: Allison C; Lai H C; Hughes C
Co-ordinate expression of virulence genes during swarm-cell differentiation and population migration of Proteus mirabilis.
Molecular microbiology 1992;6(12):1583-91.
1992: Bailey M J; Koronakis V; Schmoll T; Hughes C
Escherichia coli HlyT protein, a transcriptional activator of haemolysin synthesis and secretion, is encoded by the rfaH (sfrB) locus required for expression of sex factor and lipopolysaccharide genes.
Molecular microbiology 1992;6(8):1003-12.
1991: Koronakis V; Hughes C; Koronakis E
Energetically distinct early and late stages of HlyB/HlyD-dependent secretion across both Escherichia coli membranes.
The EMBO journal 1991;10(11):3263-72.
1991: Stanley P; Koronakis V; Hughes C
Mutational analysis supports a role for multiple structural features in the C-terminal secretion signal of Escherichia coli haemolysin.
Molecular microbiology 1991;5(10):2391-403.
1991: Diaz P; Hughes C; Juárez A
Loss of secreted hemolysin activity in the mutant strain Hsb. 1 is due to a lesion in a plasmid copy number locus.
FEMS microbiology letters 1991;67(1):55-8.
1991: Allison C; Hughes C
Closely linked genetic loci required for swarm cell differentiation and multicellular migration by Proteus mirabilis.
Molecular microbiology 1991;5(8):1975-82.
1991: Hardie K R; Issartel J P; Koronakis E; Hughes C; Koronakis V
In vitro activation of Escherichia coli prohaemolysin to the mature membrane-targeted toxin requires HlyC and a low molecular-weight cytosolic polypeptide.
Molecular microbiology 1991;5(7):1669-79.
1991: Issartel J P; Koronakis V; Hughes C
Activation of Escherichia coli prohaemolysin to the mature toxin by acyl carrier protein-dependent fatty acylation.
Nature 1991;351(6329):759-61.
1991: Allison C; Hughes C
Bacterial swarming: an example of prokaryotic differentiation and multicellular behaviour.
Science progress 1991;75(298 Pt 3-4):403-22.
1990: Cross M A; Koronakis V; Stanley P L; Hughes C
HlyB-dependent secretion of hemolysin by uropathogenic Escherichia coli requires conserved sequences flanking the chromosomal hly determinant.
Journal of bacteriology 1990;172(3):1217-24.
1989: Koronakis V; Cross M; Hughes C
Transcription antitermination in an Escherichia coli haemolysin operon is directed progressively by cis-acting DNA sequences upstream of the promoter region.
Molecular microbiology 1989;3(10):1397-404.
1989: Koronakis V; Koronakis E; Hughes C
Isolation and analysis of the C-terminal signal directing export of Escherichia coli hemolysin protein across both bacterial membranes.
The EMBO journal 1989;8(2):595-605.
1988: Koronakis V; Koronakis E; Hughes C
Comparison of the haemolysin secretion protein HlyB from Proteus vulgaris and Escherichia coli; site-directed mutagenesis causing impairment of export function.
Molecular & general genetics : MGG 1988;213(2-3):551-5.
1988: Koronakis V E; Ross A M; Le Page R W; Hughes C
Nuclear factors binding to the mini-exon repeat of Trypanosoma brucei.
Molecular and biochemical parasitology 1988;30(1):89-96.
1988: Koronakis V; Hughes C
Identification of the promoters directing in vivo expression of hemolysin genes in Proteus vulgaris and Escherichia coli.
Molecular & general genetics : MGG 1988;213(1):99-104.
1988: Koronakis V; Cross M; Hughes C
Expression of the E.coli hemolysin secretion gene hlyB involves transcript anti-termination within the hly operon.
Nucleic acids research 1988;16(11):4789-800.
1987: Koronakis V; Cross M; Senior B; Koronakis E; Hughes C
The secreted hemolysins of Proteus mirabilis, Proteus vulgaris, and Morganella morganii are genetically related to each other and to the alpha-hemolysin of Escherichia coli.
Journal of bacteriology 1987;169(4):1509-15.

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