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Michael Hughes

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Lu Zheng; Joseph J Eron; Michael F Para; Susan L Rosenkranz; Babafemi Taiwo; Michael D Hughes
The design of single-arm clinical trials of combination antiretroviral regimens for treatment-naive HIV-infected patients.
Farzad Noubary; Michael D Hughes
Factors affecting timing of antiretroviral treatment initiation based on monitoring CD4 counts.
Avy Violari; Elizabeth Petzold; Lynette Purdue; Werner Schimana; Elaine J Abrams; Linda Barlow-Mosha; Raziya Bobat; Benjamin H Chi; Mark F Cotton; Susan H Eshleman; Michael D Hughes; Patrick Jean-Philippe; Portia Kamthunzi; Sandhya Khadse; Jane C Lindsey; Linda Millar; Lynne M Mofenson; Harry Moultrie; Hilda A Mujuru; Paul Palumbo
Nevirapine versus ritonavir-boosted lopinavir for HIV-infected children.

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All Publications

2013: Lu Zheng; Joseph J Eron; Michael F Para; Susan L Rosenkranz; Babafemi Taiwo; Michael D Hughes
The design of single-arm clinical trials of combination antiretroviral regimens for treatment-naive HIV-infected patients.
AIDS research and human retroviruses 2013;29(4):652-7.
2012: Farzad Noubary; Michael D Hughes
Factors affecting timing of antiretroviral treatment initiation based on monitoring CD4 counts.
Journal of acquired immune deficiency syndromes (1999) 2012;61(3):326-33.
2012: Avy Violari; Elizabeth Petzold; Lynette Purdue; Werner Schimana; Elaine J Abrams; Linda Barlow-Mosha; Raziya Bobat; Benjamin H Chi; Mark F Cotton; Susan H Eshleman; Michael D Hughes; Patrick Jean-Philippe; Portia Kamthunzi; Sandhya Khadse; Jane C Lindsey; Linda Millar; Lynne M Mofenson; Harry Moultrie; Hilda A Mujuru; Paul Palumbo
Nevirapine versus ritonavir-boosted lopinavir for HIV-infected children.
The New England journal of medicine 2012;366(25):2380-9.
2011: Scott Dryden-Peterson; Max Essex; Michael D Hughes; Oluwemimo Jayeoba; Haruna Jibril; Koona Keapoletswe; Joseph Makhema; Taolo A Modise; sikhulile moyo; Roger L Shapiro; Josephine Tlale; Erik van Widenfelt; Aida Asmelash; Shahin Lockman
Highly active antiretroviral therapy versus zidovudine for prevention of mother-to-child transmission in a programmatic setting, Botswana.
Journal of acquired immune deficiency syndromes (1999) 2011;58(3):353-7.
2011: Kathleen M Powis; Erik van Widenfelt; Max Essex; Michael D Hughes; Douglas Kitch; Jean Leidner; Shahin Lockman; Joseph Makhema; Claire Moffat; sikhulile moyo; Anthony Ogwu; Roger L Shapiro
Increased risk of preterm delivery among HIV-infected women randomized to protease versus nucleoside reverse transcriptase inhibitor-based HAART during pregnancy.
The Journal of infectious diseases 2011;204(4):506-14.
2011: Scott Dryden-Peterson; Max Essex; Michael D Hughes; Joseph Makhema; Claire Moffat; sikhulile moyo; Anthony Ogwu; Kathleen Powis; Roger L Shapiro; Shahin Lockman
Increased risk of severe infant anemia after exposure to maternal HAART, Botswana.
Journal of acquired immune deficiency syndromes (1999) 2011;56(5):428-36.
2010: Joseph Cervia; Caroline J Chantry; Michael D Hughes; Carmelita Alvero; William A Meyer; Janice Hodge; Peggy Borum; Jack Moye; Stephen A Spector
Associations of proinflammatory cytokine levels with lipid profiles, growth, and body composition in HIV-infected children initiating or changing antiretroviral therapy.
The Pediatric infectious disease journal 2010;29(12):1118-22.
2010: Paul Palumbo; Jane C Lindsey; Michael D Hughes; Mark F Cotton; Raziya Bobat; Tammy M Meyers; Mutsawashe Bwakura-Dangarembizi; Benjamin H Chi; Philippa Musoke; Portia Kamthunzi; Werner Schimana; Lynette Purdue; Susan H Eshleman; Elaine J Abrams; Linda Millar; Elizabeth Petzold; Lynne M Mofenson; Patrick Jean-Philippe; Avy Violari
Antiretroviral treatment for children with peripartum nevirapine exposure.
The New England journal of medicine 2010;363(16):1510-20.
2010: Shahin Lockman; Michael D Hughes; James McIntyre; Yu Zheng; Tsungai Chipato; Francesca Conradie; Fred Sawe; Aida Asmelash; Mina C Hosseinipour; Lerato Mohapi; Elizabeth Stringer; Rosie Mngqibisa; Abraham Siika; Diana Atwine; James Hakim; Douglas Shaffer; Cecilia Kanyama; Kara Wools-Kaloustian; Robert A Salata; Evelyn Hogg; Beverly Alston-Smith; Ann Walawander; Eva Purcelle-Smith; Susan H Eshleman; James Rooney; Sibtain Rahim; John W Mellors; Robert T Schooley; Judith S Currier
Antiretroviral therapies in women after single-dose nevirapine exposure.
The New England journal of medicine 2010;363(16):1499-509.
2010: Caroline J Chantry; Joseph S Cervia; Michael D Hughes; C Alvero; J Hodge; P Borum; Jack Moye
Predictors of growth and body composition in HIV-infected children beginning or changing antiretroviral therapy.
HIV medicine 2010;11(9):573-83.
2010: Farzad Noubary; Michael D Hughes
Assessing agreement in the timing of treatment initiation determined by repeated measurements of novel versus gold standard technologies with application to the monitoring of CD4 counts in HIV-infected patients.
Statistics in medicine 2010;29(18):1932-46.
2010: Judith J Lok; Ronald J Bosch; Constance A Benson; Ann C Collier; Gregory K Robbins; Robert W Shafer; Michael D Hughes
Long-term increase in CD4+ T-cell counts during combination antiretroviral therapy for HIV-1 infection.
AIDS (London, England) 2010;24(12):1867-76.
2010: Paige L Williams; Miguel Marino; Kathleen Malee; Susan Brogly; Michael D Hughes; Lynne M Mofenson
Neurodevelopment and in utero antiretroviral exposure of HIV-exposed uninfected infants.
Pediatrics 2010;125(2):e250-60.
2009: Zhaohui Su; Roy M Gulick; Amy Krambrink; Eoin Coakley; Michael D Hughes; Dong Han; Charles Flexner; Timothy J Wilkin; Paul R Skolnik; Wayne L Greaves; Daniel R Kuritzkes; Jacqueline D Reeves
Response to vicriviroc in treatment-experienced subjects, as determined by an enhanced-sensitivity coreceptor tropism assay: reanalysis of AIDS clinical trials group A5211.
The Journal of infectious diseases 2009;200(11):1724-8.
2009: Harland S Winter; James M Oleske; Michael D Hughes; Ross E McKinney; Carol Elgie; Christine Powell; Lynette Purdue; Ana M Puga; Eleanor Jimenez; Gwendolyn B Scott; Maria Leticia Santos Cruz; Jack Moye
Randomized controlled trial of feeding a concentrated formula to infants born to women infected by human immunodeficiency virus.
Journal of pediatric gastroenterology and nutrition 2009;49(2):222-32.
2009: Athe M N Tsibris; Roger Paredes; Amy Chadburn; Zhaohui Su; Timothy J Henrich; Amy Krambrink; Michael D Hughes; Judith A Aberg; Judith S Currier; Karen Tashima; Catherine Godfrey; Wayne Greaves; Charles Flexner; Paul R Skolnik; Timothy J Wilkin; Roy M Gulick; Daniel R Kuritzkes
Lymphoma diagnosis and plasma Epstein-Barr virus load during vicriviroc therapy: results of the AIDS Clinical Trials Group A5211.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2009;48(5):642-9.
2009: Athe M N Tsibris; Bette Korber; Ramy Arnaout; Carsten Russ; Chien-Chi Lo; Thomas Leitner; Brian Gaschen; James Theiler; Roger Paredes; Zhaohui Su; Michael D Hughes; Roy M Gulick; Wayne Greaves; Eoin Coakley; Charles Flexner; Chad Nusbaum; Daniel R Kuritzkes
Quantitative deep sequencing reveals dynamic HIV-1 escape and large population shifts during CCR5 antagonist therapy in vivo.
PloS one 2009;4(5):e5683.
2008: Lixia Pei; Michael D Hughes
A statistical framework for quantile equivalence clinical trials with application to pharmacokinetic studies that bridge from HIV-infected adults to children.
Biometrics 2008;64(4):1117-25.
2008: Kumud K Singh; Michael D Hughes; Jie Chen; Kelesitse Phiri; Christine Rousseau; Louise Kuhn; Anna Coutsoudis; J Brooks Jackson; Laura A Guay; Philippa Musoke; Francis Mmiro; Richard D Semba; Stephen A Spector
Associations of chemokine receptor polymorphisms With HIV-1 mother-to-child transmission in sub-Saharan Africa: possible modulation of genetic effects by antiretrovirals.
Journal of acquired immune deficiency syndromes (1999) 2008;49(3):259-65.
2008: Michael D Hughes
Practical issues arising in an exploratory analysis evaluating progression-free survival as a surrogate endpoint for overall survival in advanced colorectal cancer.
Statistical methods in medical research 2008;17(5):487-95.
2008: Caroline J Chantry; Michael D Hughes; Carmelita Alvero; Joseph S Cervia; Janice Hodge; Peggy Borum; Jack Moye
Insulin-like growth factor-1 and lean body mass in HIV-infected children.
Journal of acquired immune deficiency syndromes (1999) 2008;48(4):437-43.
2008: Caroline J Chantry; Michael D Hughes; Carmelita Alvero; Joseph S Cervia; William A Meyer; Janice Hodge; Peggy Borum; Jack Moye
Lipid and glucose alterations in HIV-infected children beginning or changing antiretroviral therapy.
Pediatrics 2008;122(1):e129-38.
2008: Yvonne Bryson; M Mirochnick; Alice Stek; Lynne M Mofenson; J Connor; E Capparelli; D Heather Watts; S Huang; Michael D Hughes; K Kaiser; Lynette Purdue; Y Asfaw; M Keller; Elizabeth Smith
Pharmacokinetics and safety of nelfinavir when used in combination with zidovudine and lamivudine in HIV-infected pregnant women: Pediatric AIDS Clinical Trials Group (PACTG) Protocol 353.
HIV clinical trials 2008;9(2):115-25.
2007: Patricia M Flynn; Bret J Rudy; Jane C Lindsey; Steven D Douglas; Janet L Lathey; Stephen A Spector; Jaime Martinez; Margarita Silio; Marvin Belzer; Lawrence B Friedman; Lawrence D'Angelo; Elizabeth Smith; Janice Hodge; Michael D Hughes
Long-term observation of adolescents initiating HAART therapy: three-year follow-up.
AIDS research and human retroviruses 2007;23(10):1208-14.
2007: Carmen D Zorrilla; Russell Van Dyke; Arlene Bardeguez; Edward P Acosta; Betsy Smith; Michael D Hughes; Sharon Huang; D Heather Watts; Barbara Heckman; Eleanor Jiménez; George McSherry; Lynne Mofenson
Clinical response and tolerability to and safety of saquinavir with low-dose ritonavir in human immunodeficiency virus type 1-infected mothers and their infants.
Antimicrobial agents and chemotherapy 2007;51(6):2208-10.
2007: Susan Brogly; Nathalie Ylitalo; Lynne M Mofenson; James M Oleske; Russell Van Dyke; Marilyn J Crain; Mark J Abzug; Michael T Brady; Patrick Jean-Philippe; Michael D Hughes; George R Seage
In utero nucleoside reverse transcriptase inhibitor exposure and signs of possible mitochondrial dysfunction in HIV-uninfected children.
AIDS (London, England) 2007;21(8):929-38.
2007: Michael D Hughes; Paige L Williams
Challenges in using observational studies to evaluate adverse effects of treatment.
The New England journal of medicine 2007;356(17):1705-7.
2007: Jane C Lindsey; Kathleen Malee; Pim Brouwers; Michael D Hughes
Neurodevelopmental functioning in HIV-infected infants and young children before and after the introduction of protease inhibitor-based highly active antiretroviral therapy.
Pediatrics 2007;119(3):e681-93.
2007: Jashvant D Unadkat; Diane Wara; Michael D Hughes; Anita A Mathias; Diane T Holland; Mary E Paul; James Connor; Sharon Huang; Bach-Yen Nguyen; D Heather Watts; Lynne M Mofenson; Elizabeth Smith; Paul Deutsch; Kathleen A Kaiser; Ruth E Tuomala
Pharmacokinetics and safety of indinavir in human immunodeficiency virus-infected pregnant women.
Antimicrobial agents and chemotherapy 2007;51(2):783-6.
2006: Nathalie Ylitalo; Susan Brogly; Michael D Hughes; Sharon Nachman; Wayne M Dankner; Russell Van Dyke; George R Seage
Risk factors for opportunistic illnesses in children with human immunodeficiency virus in the era of highly active antiretroviral therapy.
Archives of pediatrics & adolescent medicine 2006;160(8):778-87.
2006: Katherine K Tassiopoulos; George R Seage; Noel E Sam; Trong T H Ao; Elisante J Masenga; Michael D Hughes; Saidi H Kapiga
Sexual behavior, psychosocial and knowledge differences between consistent, inconsistent and non-users of condoms: a study of female bar and hotel workers in Moshi, Tanzania.
AIDS and behavior 2006;10(4):405-13.
2006: Pamela J Surkan; Karen E Peterson; Michael D Hughes; Barbara R Gottlieb
The role of social networks and support in postpartum women's depression: a multiethnic urban sample.
Maternal and child health journal 2006;10(4):375-83.
2006: Grace M Lee; Steven L Gortmaker; Kenneth McIntosh; Michael D Hughes; James M Oleske
Quality of life for children and adolescents: impact of HIV infection and antiretroviral treatment.
Pediatrics 2006;117(2):273-83.
2005: Jennifer R King; Sharon Nachman; Ram Yogev; Janice Hodge; Grace M Aldrovandi; Michael D Hughes; Jie Chen; Andrew Wiznia; Bharat Damle; Edward P Acosta
Efficacy, tolerability and pharmacokinetics of two nelfinavir-based regimens in human immunodeficiency virus-infected children and adolescents: pediatric AIDS clinical trials group protocol 403.
The Pediatric infectious disease journal 2005;24(10):880-5.
2005: Kumud K Singh; Michael D Hughes; Jie Chen; Stephen A Spector
Genetic polymorphisms in CX3CR1 predict HIV-1 disease progression in children independently of CD4+ lymphocyte count and HIV-1 RNA load.
The Journal of infectious diseases 2005;191(11):1971-80.
2004: Patricia M Flynn; Bret J Rudy; Steven D Douglas; Janet L Lathey; Stephen A Spector; Jaime Martinez; Margarita Silio; Marvin Belzer; Lawrence B Friedman; Lawrence D'Angelo; James McNamara; Janice Hodge; Michael D Hughes; Jane C Lindsey
Virologic and immunologic outcomes after 24 weeks in HIV type 1-infected adolescents receiving highly active antiretroviral therapy.
The Journal of infectious diseases 2004;190(2):271-9.
2004: Denise M Gaughan; Michael D Hughes; James M Oleske; Kathleen Malee; Carol A Gore; Sharon Nachman
Psychiatric hospitalizations among children and youths with human immunodeficiency virus infection.
Pediatrics 2004;113(6):e544-51.
2004: Kumud K Singh; Charlene F Barroga; Michael D Hughes; Jie Chen; Claire Raskino; Ross E McKinney; Stephen A Spector
Prevalence of chemokine and chemokine receptor polymorphisms in seroprevalent children with symptomatic HIV-1 infection in the United States.
Journal of acquired immune deficiency syndromes (1999) 2004;35(3):309-13.
2004: Hulin Wu; Janet L Lathey; Ping Ruan; Steven D Douglas; Stephen A Spector; Jane Lindsey; Michael D Hughes; Bret J Rudy; Patricia M Flynn
Relationship of plasma HIV-1 RNA dynamics to baseline factors and virological responses to highly active antiretroviral therapy in adolescents (aged 12-22 years) infected through high-risk behavior.
The Journal of infectious diseases 2004;189(4):593-601.
2004: Kumud K Singh; Michael D Hughes; Jie Chen; Stephen A Spector
Lack of protective effects of interleukin-4 -589-C/T polymorphism against HIV-1-related disease progression and central nervous system impairment, in children.
The Journal of infectious diseases 2004;189(4):587-92.
2004: Edward P Acosta; Arlene Bardeguez; Carmen D Zorrilla; Russell Van Dyke; Michael D Hughes; Sharon Huang; Lisa Pompeo; Alice Stek; Jane Pitt; D Heather Watts; Elizabeth Smith; Eleanor Jiménez; Lynne Mofenson
Pharmacokinetics of saquinavir plus low-dose ritonavir in human immunodeficiency virus-infected pregnant women.
Antimicrobial agents and chemotherapy 2004;48(2):430-6.
2003: Chang-Heok Soh; James M Oleske; Michael T Brady; Stephen A Spector; William Borkowsky; Sandra K Burchett; Marc D Foca; Edward Handelsman; Eleanor Jiménez; Wayne M Dankner; Michael D Hughes
Long-term effects of protease-inhibitor-based combination therapy on CD4 T-cell recovery in HIV-1-infected children and adolescents.
Lancet 2003;362(9401):2045-51.
2003: Kumud K Singh; Charlene F Barroga; Michael D Hughes; Jie Chen; Claire Raskino; Ross E McKinney; Stephen A Spector
Genetic influence of CCR5, CCR2, and SDF1 variants on human immunodeficiency virus 1 (HIV-1)-related disease progression and neurological impairment, in children with symptomatic HIV-1 infection.
The Journal of infectious diseases 2003;188(10):1461-72.
2003: Kate Buchacz; Alan D Rogol; Jane C Lindsey; Craig M Wilson; Michael D Hughes; George R Seage; James M Oleske; Audrey Smith Rogers
Delayed onset of pubertal development in children and adolescents with perinatally acquired HIV infection.
Journal of acquired immune deficiency syndromes (1999) 2003;33(1):56-65.
2002: Michael D Hughes
Evaluating surrogate endpoints.
Controlled clinical trials 2002;23(6):703-7.
2002: Ruth E Tuomala; David E Shapiro; Lynne M Mofenson; Yvonne Bryson; Mary Culnane; Michael D Hughes; Mary J O'Sullivan; Gwendolyn B Scott; Alice Stek; Diane Wara; Marc Bulterys
Antiretroviral therapy during pregnancy and the risk of an adverse outcome.
The New England journal of medicine 2002;346(24):1863-70.
2002: Denise M Gaughan; Michael D Hughes; George R Seage; Peter A Selwyn; Vincent J Carey; Steven L Gortmaker; James M Oleske
The prevalence of pain in pediatric human immunodeficiency virus/acquired immunodeficiency syndrome as reported by participants in the Pediatric Late Outcomes Study (PACTG 219).
Pediatrics 2002;109(6):1144-52.
2002: Lisa M Demeter; Ronald J Bosch; Robert W Coombs; Susan A Fiscus; James Bremer; Victoria A Johnson; Alejo Erice; J Brooks Jackson; Stephen A Spector; Kathleen M Squires; Margaret A Fischl; Michael D Hughes; Scott M Hammer
Detection of replication-competent human immunodeficiency virus type 1 (HIV-1) in cultures from patients with levels of HIV-1 RNA in plasma suppressed to less than 500 or 50 copies per milliliter.
Journal of clinical microbiology 2002;40(6):2089-94.
2002: Denise M Gaughan; Lynne M Mofenson; Michael D Hughes; George R Seage; Gregory L Ciupak; James M Oleske
Osteonecrosis of the hip (Legg-Calvé-Perthes disease) in human immunodeficiency virus-infected children.
Pediatrics 2002;109(5):E74-4.
2001: Lisa M Demeter; Michael D Hughes; Robert W Coombs; J Brooks Jackson; J M Grimes; Ronald J Bosch; Susan A Fiscus; Stephen A Spector; Kathleen E Squires; Margaret A Fischl; Scott M Hammer
Predictors of virologic and clinical outcomes in HIV-1-infected patients receiving concurrent treatment with indinavir, zidovudine, and lamivudine. AIDS Clinical Trials Group Protocol 320.
Annals of internal medicine 2001;135(11):954-64.
2001: Kate Buchacz; Joseph Cervia; Jane C Lindsey; Michael D Hughes; George R Seage; Wayne M Dankner; James M Oleske; Jack Moye
Impact of protease inhibitor-containing combination antiretroviral therapies on height and weight growth in HIV-infected children.
Pediatrics 2001;108(4):E72.
2001: D A Katzenstein; Michael D Hughes; M Albrecht; S H Liou; R Murphy; Henry H Balfour; Michael F Para; S Hammer
Virologic and CD4 cell response to zidovudine or zidovudine and lamivudine following didanosine treatment of human immunodeficiency virus infection.
AIDS research and human retroviruses 2001;17(3):203-10.
2000: Jane C Lindsey; Michael D Hughes; Ross E McKinney; M K Cowles; Janet A Englund; Carol J Baker; Sandra K Burchett; Mark W Kline; Andrea Kovacs; Jack Moye
Treatment-mediated changes in human immunodeficiency virus (HIV) type 1 RNA and CD4 cell counts as predictors of weight growth failure, cognitive decline, and survival in HIV-infected children.
The Journal of infectious diseases 2000;182(5):1385-93.
2000: M A Albrecht; Michael D Hughes; S H Liou; David A Katzenstein; R Murphy; Henry H Balfour; Michael F Para; Hernan Valdez; Scott M Hammer
Effect of lamivudine in HIV-infected persons with prior exposure to zidovudine/didanosine or zidovudine/zalcitabine.
AIDS research and human retroviruses 2000;16(14):1337-44.
2000: Judith S Currier; C Spino; J Grimes; C B Wofsy; David A Katzenstein; Michael D Hughes; Scott M Hammer; Deborah Cotton
Differences between women and men in adverse events and CD4+ responses to nucleoside analogue therapy for HIV infection. The Aids Clinical Trials Group 175 Team.
Journal of acquired immune deficiency syndromes (1999) 2000;24(4):316-24.
2000: S Kim; Michael D Hughes; Scott M Hammer; J Brooks Jackson; Victor DeGruttola; David A Katzenstein
Both serum HIV type 1 RNA levels and CD4+ lymphocyte counts predict clinical outcome in HIV type 1-infected subjects with 200 to 500 CD4+ cells per cubic millimeter. AIDS Clinical Trials Group Study 175 Virology Study Team.
AIDS research and human retroviruses 2000;16(7):645-53.
1999: XJ Zhou; L B Sheiner; Richard T D'Aquila; Michael D Hughes; M S Hirsch; Margaret A Fischl; Victoria A Johnson; M Myers; Jean-Pierre Sommadossi
Population pharmacokinetics of nevirapine, zidovudine, and didanosine in human immunodeficiency virus-infected patients. The National Institute of Allergy and Infectious Diseases AIDS Clinical Trials Group Protocol 241 Investigators.
Antimicrobial agents and chemotherapy 1999;43(1):121-8.
1998: Michael D Hughes; M J Daniels; Margaret A Fischl; S Kim; Robert T Schooley
CD4 cell count as a surrogate endpoint in HIV clinical trials: a meta-analysis of studies of the AIDS Clinical Trials Group.
AIDS (London, England) 1998;12(14):1823-32.
1998: Richard T D'Aquila; Lorraine Sutton; AV Savara; Michael D Hughes; Victoria A Johnson
CCR5/delta(ccr5) heterozygosity: a selective pressure for the syncytium-inducing human immunodeficiency virus type 1 phenotype. NIAID AIDS Clinical Trials Group Protocol 241 Virology Team.
The Journal of infectious diseases 1998;177(6):1549-53.
1998: Susan A Fiscus; Michael D Hughes; Janet L Lathey; T Pi; J Brooks Jackson; Suraiya Rasheed; T Elbeik; R Reichman; AJ Japour; R Byington; Walter A Scott; B P Griffith; David A Katzenstein; Scott M Hammer
Changes in virologic markers as predictors of CD4 cell decline and progression of disease in human immunodeficiency virus type 1-infected adults treated with nucleosides. AIDS Clinical Trials Group Protocol 175 Team.
The Journal of infectious diseases 1998;177(3):625-33.
1998: Janet L Lathey; Michael D Hughes; Susan A Fiscus; T Pi; J Brooks Jackson; Suraiya Rasheed; T Elbeik; R Reichman; AJ Japour; Richard T D'Aquila; Walter A Scott; B P Griffith; Scott M Hammer; David A Katzenstein
Variability and prognostic values of virologic and CD4 cell measures in human immunodeficiency virus type 1-infected patients with 200-500 CD4 cells/mm(3) (ACTG 175). AIDS Clinical Trials Group Protocol 175 Team.
The Journal of infectious diseases 1998;177(3):617-24.
1998: Ian C Marschner; Ann C Collier; Robert W Coombs; Richard T D'Aquila; Victor DeGruttola; Margaret A Fischl; Scott M Hammer; Michael D Hughes; Victoria A Johnson; David A Katzenstein; Douglas D Richman; Laura M Smeaton; Stephen A Spector; M S Saag
Use of changes in plasma levels of human immunodeficiency virus type 1 RNA to assess the clinical benefit of antiretroviral therapy.
The Journal of infectious diseases 1998;177(1):40-7.
1997: Scott M Hammer; Kathleen E Squires; Michael D Hughes; J M Grimes; Lisa M Demeter; Judith S Currier; Joseph J Eron; Judith E Feinberg; Henry H Balfour; L R Deyton; J A Chodakewitz; Margaret A Fischl
A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less. AIDS Clinical Trials Group 320 Study Team.
The New England journal of medicine 1997;337(11):725-33.
1997: H M Lin; Michael D Hughes
Assessing the effects of interventions using longitudinal data with samples subject to selection.
Biometrics 1997;53(3):924-36.
1997: Michael D Hughes; Victoria A Johnson; Martin S Hirsch; J W Bremer; T Elbeik; Alejo Erice; Daniel R Kuritzkes; Walter A Scott; Stephen A Spector; Nesli Basgoz; Margaret A Fischl; Richard T D'Aquila
Monitoring plasma HIV-1 RNA levels in addition to CD4+ lymphocyte count improves assessment of antiretroviral therapeutic response. ACTG 241 Protocol Virology Substudy Team.
Annals of internal medicine 1997;126(12):929-38.
1997: H M Lin; Michael D Hughes
Adjusting for regression toward the mean when variables are normally distributed.
Statistical methods in medical research 1997;6(2):129-46.
1997: Michael D Hughes
Power considerations for clinical trials using multivariate time-to-event data.
Statistics in medicine 1997;16(8):865-82.
1996: H M Lin; Michael D Hughes
Analysis of uncontrolled treatment changes in HIV clinical trails.
Statistics in medicine 1996;15(19):2053-67.
1996: David A Katzenstein; Scott M Hammer; Michael D Hughes; H Gundacker; J Brooks Jackson; Susan A Fiscus; Suraiya Rasheed; T Elbeik; Richard C Reichman; AJ Japour; T C Merigan; Martin S Hirsch
The relation of virologic and immunologic markers to clinical outcomes after nucleoside therapy in HIV-infected adults with 200 to 500 CD4 cells per cubic millimeter. AIDS Clinical Trials Group Study 175 Virology Study Team.
The New England journal of medicine 1996;335(15):1091-8.
1996: Scott M Hammer; David A Katzenstein; Michael D Hughes; H Gundacker; R T Schooley; R H Haubrich; W K Henry; Michael M Lederman; J P Phair; M Niu; Martin S Hirsch; T C Merigan
A trial comparing nucleoside monotherapy with combination therapy in HIV-infected adults with CD4 cell counts from 200 to 500 per cubic millimeter. AIDS Clinical Trials Group Study 175 Study Team.
The New England journal of medicine 1996;335(15):1081-90.
1996: Richard T D'Aquila; Michael D Hughes; Victoria A Johnson; Margaret A Fischl; Jean-Pierre Sommadossi; S H Liou; J Timpone; M Myers; Nesli Basgoz; M Niu; Martin S Hirsch
Nevirapine, zidovudine, and didanosine compared with zidovudine and didanosine in patients with HIV-1 infection. A randomized, double-blind, placebo-controlled trial. National Institute of Allergy and Infectious Diseases AIDS Clinical Trials Group Protocol 241 Investigators.
Annals of internal medicine 1996;124(12):1019-30.
1995: H M Lin; Michael D Hughes
Use of historical marker data for assessing treatment effects in phase I/II trials when subject selection is determined by baseline marker level.
Biometrics 1995;51(3):1053-63.
1995: Michael D Hughes; Victor DeGruttola; Seth Welles
Evaluating surrogate markers.
Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association 1995;10 Suppl 2():S1-8.
1994: Michael D Hughes; D S Stein; H M Gundacker; Fred Valentine; J P Phair; P A Volberding
Within-subject variation in CD4 lymphocyte count in asymptomatic human immunodeficiency virus infection: implications for patient monitoring.
The Journal of infectious diseases 1994;169(1):28-36.
1993: Michael D Hughes
Regression dilution in the proportional hazards model.
Biometrics 1993;49(4):1056-66.
1993: Michael D Hughes
Reporting Bayesian analyses of clinical trials.
Statistics in medicine 1993;12(18):1651-63.
1993: Michael D Hughes
Stopping guidelines for clinical trials with multiple treatments.
Statistics in medicine 1993;12(10):901-15.