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Philip Hughes

Research Profile

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Publications

TOP 3
Geoffrey Brown; Philip J Hughes; Rhodri Ceredig
The versatile landscape of haematopoiesis: are leukaemia stem cells as versatile?
Geoffrey Brown; Philip J Hughes
A role for caspase inhibitors in differentiation therapy of myeloid leukaemia.
Geoffrey Brown; Philip J Hughes; Robert H Michell; Rhodri Ceredig
The versatility of haematopoietic stem cells: implications for leukaemia.

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All Publications

2012: Geoffrey Brown; Philip J Hughes; Rhodri Ceredig
The versatile landscape of haematopoiesis: are leukaemia stem cells as versatile?
Critical reviews in clinical laboratory sciences 2012;49(5-6):232-40.
2012: Geoffrey Brown; Philip J Hughes
A role for caspase inhibitors in differentiation therapy of myeloid leukaemia.
Leukemia research 2012;36(7):808-10.
2010: Geoffrey Brown; Philip J Hughes; Robert H Michell; Rhodri Ceredig
The versatility of haematopoietic stem cells: implications for leukaemia.
Critical reviews in clinical laboratory sciences 2010;47(4):171-80.
2010: Philip J Hughes; Ewa Marcinkowska; Elzbieta Gocek; George P Studzinski; Geoffrey Brown
Vitamin D3-driven signals for myeloid cell differentiation--implications for differentiation therapy.
Leukemia research 2010;34(5):553-65.
2008: Philip J Hughes; Jimmy S Lee; Neil E Reiner; Geoffrey Brown
The vitamin D receptor-mediated activation of phosphatidylinositol 3-kinase (PI3Kalpha) plays a role in the 1alpha,25-dihydroxyvitamin D3-stimulated increase in steroid sulphatase activity in myeloid leukaemic cell lines.
Journal of cellular biochemistry 2008;103(5):1551-72.
2007: Geoffrey Brown; Philip J Hughes; Robert H Michell; Antonius G Rolink; Rhodri Ceredig
The sequential determination model of hematopoiesis.
Trends in immunology 2007;28(10):442-8.
2006: Philip J Hughes; Geoffrey Brown
1Alpha,25-dihydroxyvitamin D3-mediated stimulation of steroid sulphatase activity in myeloid leukaemic cell lines requires VDRnuc-mediated activation of the RAS/RAF/ERK-MAP kinase signalling pathway.
Journal of cellular biochemistry 2006;98(3):590-617.
2006: Philip J Hughes; Yi Zhao; Roshantha A S Chandraratna; Geoffrey Brown
Retinoid-mediated stimulation of steroid sulfatase activity in myeloid leukemic cell lines requires RARalpha and RXR and involves the phosphoinositide 3-kinase and ERK-MAP kinase pathways.
Journal of cellular biochemistry 2006;97(2):327-50.
2005: Philip J Hughes; Andreas Steinmeyer; Roshantha A S Chandraratna; Geoffrey Brown
1alpha,25-dihydroxyvitamin D3 stimulates steroid sulphatase activity in HL60 and NB4 acute myeloid leukaemia cell lines by different receptor-mediated mechanisms.
Journal of cellular biochemistry 2005;94(6):1175-89.
2004: Christopher J Barker; Joanne Wright; Philip J Hughes; Christopher J Kirk; Robert H Michell
Complex changes in cellular inositol phosphate complement accompany transit through the cell cycle.
The Biochemical journal 2004;380(Pt 2):465-73.
2004: Robert M Harris; D M Wood; L Bottomley; Simone L Blagg; Katharine Owen; Philip J Hughes; Rosemary H Waring; Christopher J Kirk
Phytoestrogens are potent inhibitors of estrogen sulfation: implications for breast cancer risk and treatment.
The Journal of clinical endocrinology and metabolism 2004;89(4):1779-87.
2003: Geoffrey Brown; Philip J Hughes; Robert H Michell
Cell differentiation and proliferation--simultaneous but independent?
Experimental cell research 2003;291(2):282-8.
2002: Geoffrey Brown; Mark T Drayson; Jennifer Durham; Kai-Michael Toellner; Philip J Hughes; M Ansar Choudhry; Dale R Taylor; Roger Bird; Robert H Michell
HL60 cells halted in G1 or S phase differentiate normally.
Experimental cell research 2002;281(1):28-38.
2001: Christopher J Kirk; Robert M Harris; D M Wood; Rosemary H Waring; Philip J Hughes
Do dietary phytoestrogens influence susceptibility to hormone-dependent cancer by disrupting the metabolism of endogenous oestrogens?
Biochemical Society transactions 2001;29(Pt 2):209-16.
2001: Philip J Hughes; L E Twist; Jennifer Durham; M Ansar Choudhry; Mark T Drayson; Roshantha A S Chandraratna; Robert H Michell; Christopher J Kirk; Geoffrey Brown
Up-regulation of steroid sulphatase activity in HL60 promyelocytic cells by retinoids and 1alpha,25-dihydroxyvitamin D3.
The Biochemical journal 2001;355(Pt 2):361-71.
2000: Philip J Hughes; H McLellan; D A Lowes; S Z Kahn; Jonathan G Bilmen; SC Tovey; Rita E Godfrey; Robert H Michell; Christopher J Kirk; Francesco Michelangeli
Estrogenic alkylphenols induce cell death by inhibiting testis endoplasmic reticulum Ca(2+) pumps.
Biochemical and biophysical research communications 2000;277(3):568-74.
2000: Robert M Harris; Rosemary H Waring; Christopher J Kirk; Philip J Hughes
Sulfation of "estrogenic" alkylphenols and 17beta-estradiol by human platelet phenol sulfotransferases.
The Journal of biological chemistry 2000;275(1):159-66.
1998: P P Ongusaha; Philip J Hughes; J Davey; Robert H Michell
Inositol hexakisphosphate in Schizosaccharomyces pombe: synthesis from Ins(1,4,5)P3 and osmotic regulation.
The Biochemical journal 1998;335 ( Pt 3)():671-9.
1997: SC Tovey; Rita E Godfrey; Philip J Hughes; M Mezna; Stephen D Minchin; K Mikoshiba; Francesco Michelangeli
Identification and characterization of inositol 1,4,5-trisphosphate receptors in rat testis.
Cell calcium 1997;21(4):311-9.
1997: P P Ongusaha; Philip J Hughes; M Hirata; J Davey; Robert H Michell
The inositol 1,4,5-trisphosphate 6-kinase of Schizosaccharomyces pombe.
Biochemical Society transactions 1997;25(1):105S.
1995: S A Rudge; Philip J Hughes; G R Brown; Robert H Michell; C J Kirk
Inositol lipid-mediated signalling in response to endothelin and ATP in the mammalian testis.
Molecular and cellular biochemistry 1995;149-150():161-74.
1995: J A Stuart; Philip J Hughes; C J Kirk; John Davey; Robert H Michell
The involvement of inositol lipids and phosphates in signalling in the fission yeast Schizosaccharomyces pombe.
Biochemical Society transactions 1995;23(2):223S.
1995: John Howl; S A Rudge; R A Lavis; AR Davies; Rosemary A Parslow; Philip J Hughes; C J Kirk; Robert H Michell; Mark Wheatley
Rat testicular myoid cells express vasopressin receptors: receptor structure, signal transduction, and developmental regulation.
Endocrinology 1995;136(5):2206-13.
1994: Philip J Hughes; C J Kirk; Robert H Michell
Inhibition of porcine brain inositol 1,3,4-trisphosphate kinase by inositol polyphosphates, other polyol phosphates, polyanions and polycations.
Biochimica et biophysica acta 1994;1223(1):57-70.
1994: Matthew N Hodgkin; A Craxton; J B Parry; Philip J Hughes; B V Potter; Robert H Michell; C J Kirk
Bovine testis and human erythrocytes contain different subtypes of membrane-associated Ins(1,4,5)P3/Ins(1,3,4,5)P4 5-phosphomonoesterases.
The Biochemical journal 1994;297 ( Pt 3)():637-45.
1993: Philip J Hughes; C J Kirk; Robert H Michell
Inhibition of inositol 1,3,4-trisphosphate 5/6-kinase by amino acid modifying agents.
Biochemical Society transactions 1993;21(4):365S.
1993: S A Rudge; Philip J Hughes; C J Kirk; Robert H Michell
Endothelin-1 stimulates inositol phosphate production in rat testis.
Biochemical Society transactions 1993;21(4):364S.
1993: Philip J Hughes; Robert H Michell
Novel inositol containing phospholipids and phosphates: their synthesis and possible new roles in cellular signalling.
Current opinion in neurobiology 1993;3(3):383-400.
1992: K G Oliver; R Mark L Buller; Philip J Hughes; James W Putney; G J Palumbo
Inhibition of agonist-induced activation of phospholipase C following poxvirus infection.
The Journal of biological chemistry 1992;267(35):25098-103.
1992: M Abdullah; Philip J Hughes; A Craxton; R Gigg; T Desai; J F Marecek; G D Prestwich; Stephen B Shears
Purification and characterization of inositol-1,3,4-trisphosphate 5/6-kinase from rat liver using an inositol hexakisphosphate affinity column.
The Journal of biological chemistry 1992;267(31):22340-5.
1991: K Nogimori; Philip J Hughes; M C Glennon; M E Hodgson; James W Putney; Stephen B Shears
Purification of an inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase activity from rat liver and the evaluation of its substrate specificity.
The Journal of biological chemistry 1991;266(25):16499-506.
1990: Philip J Hughes; Stephen B Shears
Inositol 1,3,4,5,6-pentakisphosphate and inositol hexakisphosphate inhibit inositol-1,3,4,5-tetrakisphosphate 3-phosphatase in rat parotid glands.
The Journal of biological chemistry 1990;265(17):9869-75.
1990: Stephen B Shears; Philip J Hughes
The synthesis of inositol polyphosphates in rat liver by 5- and 6-kinase activities.
Symposia of the Society for Experimental Biology 1990;44():181-91.
1989: Philip J Hughes; A R Hughes; James W Putney; Stephen B Shears
The regulation of the phosphorylation of inositol 1,3,4-trisphosphate in cell-free preparations and its relevance to the formation of inositol 1,3,4,6-tetrakisphosphate in agonist-stimulated rat parotid acinar cells.
The Journal of biological chemistry 1989;264(33):19871-8.