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Ruth Hughes

Research Profile

Chemicals & Drugs

Physiology

Anatomy

Vacuoles

Procedures

Parasitic Sensitivity Tests

Disorders

Co-author Network

Publications

TOP 3
Paul A Stocks; Patrick G Bray; Victoria E Barton; Mohammed Al-Helal; Michael Jones; Nuna C Araujo; Peter Gibbons; Stephen A Ward; Ruth H Hughes; Giancarlo A Biagini; Jill Davies; Richard Amewu; Amy Mercer; Gemma Ellis; Paul M O'Neill
Evidence for a common non-heme chelatable-iron-dependent activation mechanism for semisynthetic and synthetic endoperoxide antimalarial drugs.
Patrick G Bray; Mathirut Mungthin; Ian M Hastings; Giancarlo A Biagini; Dauda K Saidu; Viswanathan Lakshmanan; David J Johnson; Ruth H Hughes; Paul A Stocks; Paul M O'Neill; Fidock David; david charles warhurst; Stephen A Ward
PfCRT and the trans-vacuolar proton electrochemical gradient: regulating the access of chloroquine to ferriprotoporphyrin IX.
Viswanathan Lakshmanan; Patrick G Bray; Dominik Verdier-Pinard; David J Johnson; Paul Horrocks; Rebecca A Muhle; George E Alakpa; Ruth H Hughes; Stephen A Ward; Donald J Krogstad; Amar Bir Singh Sidhu; Fidock David
A critical role for PfCRT K76T in Plasmodium falciparum verapamil-reversible chloroquine resistance.

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All Publications

2007: Paul A Stocks; Patrick G Bray; Victoria E Barton; Mohammed Al-Helal; Michael Jones; Nuna C Araujo; Peter Gibbons; Stephen A Ward; Ruth H Hughes; Giancarlo A Biagini; Jill Davies; Richard Amewu; Amy Mercer; Gemma Ellis; Paul M O'Neill
Evidence for a common non-heme chelatable-iron-dependent activation mechanism for semisynthetic and synthetic endoperoxide antimalarial drugs.
Angewandte Chemie (International ed. in English) 2007;46(33):6278-83.
2006: Patrick G Bray; Mathirut Mungthin; Ian M Hastings; Giancarlo A Biagini; Dauda K Saidu; Viswanathan Lakshmanan; David J Johnson; Ruth H Hughes; Paul A Stocks; Paul M O'Neill; Fidock David; david charles warhurst; Stephen A Ward
PfCRT and the trans-vacuolar proton electrochemical gradient: regulating the access of chloroquine to ferriprotoporphyrin IX.
Molecular microbiology 2006;62(1):238-51.
2005: Viswanathan Lakshmanan; Patrick G Bray; Dominik Verdier-Pinard; David J Johnson; Paul Horrocks; Rebecca A Muhle; George E Alakpa; Ruth H Hughes; Stephen A Ward; Donald J Krogstad; Amar Bir Singh Sidhu; Fidock David
A critical role for PfCRT K76T in Plasmodium falciparum verapamil-reversible chloroquine resistance.
The EMBO journal 2005;24(13):2294-305.
2003: Paul M O'Neill; Amira Mukhtar; Paul A Stocks; Laura E Randle; Stephen Hindley; Stephen A Ward; Richard C Storr; Jamie F Bickley; Ian A O'Neil; James L Maggs; Ruth H Hughes; Peter A Winstanley; Patrick G Bray; B Kevin Park
Isoquine and related amodiaquine analogues: a new generation of improved 4-aminoquinoline antimalarials.
Journal of medicinal chemistry 2003;46(23):4933-45.
2002: David G Spiller; Patrick G Bray; Ruth H Hughes; Stephen A Ward; Michael R H White
The pH of the Plasmodium falciparum digestive vacuole: holy grail or dead-end trail?
Trends in parasitology 2002;18(10):441-4.