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Rebecca Hughey

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Di Mo; Nuria Pastor-Soler; Simone A Costa; Rebecca P Hughey; Gudrun Ihrke; Robert T Youker; Ora A Weisz
Sialylation of N-linked glycans mediates apical delivery of endolyn in MDCK cells via a galectin-9-dependent mechanism.
Gunhild M Mueller; Michael A Tolino; Zhijian Wang; Wusheng Yan; Lawrence Copelovitch; Rebecca P Hughey; Susan Jarman; Carol L Kinlough; Thomas R Kleyman; Ronald C Rubenstein
Multiple residues in the distal C terminus of the α-subunit have roles in modulating human epithelial sodium channel activity.
Polly E Mattila; Di Mo; Robert T Youker; Jennifer R Bruns; Kerry O Cresawn; Rebecca P Hughey; Gudrun Ihrke; Ora A Weisz
Multiple biosynthetic trafficking routes for apically secreted proteins in MDCK cells.

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All Publications

2012: Di Mo; Nuria Pastor-Soler; Simone A Costa; Rebecca P Hughey; Gudrun Ihrke; Robert T Youker; Ora A Weisz
Sialylation of N-linked glycans mediates apical delivery of endolyn in MDCK cells via a galectin-9-dependent mechanism.
Molecular biology of the cell 2012;23(18):3636-46.
2012: Gunhild M Mueller; Michael A Tolino; Zhijian Wang; Wusheng Yan; Lawrence Copelovitch; Rebecca P Hughey; Susan Jarman; Carol L Kinlough; Thomas R Kleyman; Ronald C Rubenstein
Multiple residues in the distal C terminus of the α-subunit have roles in modulating human epithelial sodium channel activity.
American journal of physiology. Renal physiology 2012;303(2):F220-8.
2012: Polly E Mattila; Di Mo; Robert T Youker; Jennifer R Bruns; Kerry O Cresawn; Rebecca P Hughey; Gudrun Ihrke; Ora A Weisz
Multiple biosynthetic trafficking routes for apically secreted proteins in MDCK cells.
Traffic (Copenhagen, Denmark) 2012;13(3):433-42.
2012: Franz-Georg Hanisch; Carol L Kinlough; Simon Staubach; Rebecca P Hughey
MUC1 membrane trafficking: protocols for assessing biosynthetic delivery, endocytosis, recycling, and release through exosomes.
Methods in molecular biology (Clifton, N.J.) 2012;842():123-40.
2011: Carol L Kinlough; Polly E Mattila; Di Mo; Paul A Poland; Ora A Weisz; Sandra J Gendler; Rebecca P Hughey
Core-glycosylated mucin-like repeats from MUC1 are an apical targeting signal.
The Journal of biological chemistry 2011;286(45):39072-81.
2011: Christine Rondanino; Ora A Weisz; Mohammad M Al-bataineh; gerard apodaca; Kenneth R Hallows; Ossama B Kashlan; Carol L Kinlough; Hui Li; Mike M Myerburg; Nuria M Pastor-Soler; Paul A Poland; Youssef Rbaibi; Rebecca P Hughey
Galectin-7 modulates the length of the primary cilia and wound repair in polarized kidney epithelial cells.
American journal of physiology. Renal physiology 2011;301(3):F622-33.
2011: Paul A Poland; Christine Rondanino; Carol L Kinlough; Jamie Heimburg-Molinaro; Connie M Arthur; Sean R Stowell; Dave F Smith; Rebecca P Hughey
Identification and characterization of endogenous galectins expressed in Madin Darby canine kidney cells.
The Journal of biological chemistry 2011;286(8):6780-90.
2011: Ossama B Kashlan; Joshua L Adelman; Sora Okumura; Brandon M Blobner; Zachary Zuzek; Rebecca P Hughey; Thomas R Kleyman; Michael Grabe
Constraint-based, homology model of the extracellular domain of the epithelial Na+ channel α subunit reveals a mechanism of channel activation by proteases.
The Journal of biological chemistry 2011;286(1):649-60.
2010: Ossama B Kashlan; Cary R Boyd; Christos Argyropoulos; Sora Okumura; Rebecca P Hughey; Michael Grabe; Thomas R Kleyman
Allosteric inhibition of the epithelial Na+ channel through peptide binding at peripheral finger and thumb domains.
The Journal of biological chemistry 2010;285(45):35216-23.
2010: Gunhild M Mueller; Ahmad B Maarouf; Carol L Kinlough; Nan Sheng; Ossama B Kashlan; Sora Okumura; Sarah Luthy; Thomas R Kleyman; Rebecca P Hughey
Cys palmitoylation of the beta subunit modulates gating of the epithelial sodium channel.
The Journal of biological chemistry 2010;285(40):30453-62.
2010: Christopher J Passero; Marcelo D Carattino; Ossama B Kashlan; Mike M Myerburg; Rebecca P Hughey; Thomas R Kleyman
Defining an inhibitory domain in the gamma subunit of the epithelial sodium channel.
American journal of physiology. Renal physiology 2010;299(4):F854-61.
2010: Shanshan Cui; Christopher J Guerriero; Christina M Szalinski; Carol L Kinlough; Rebecca P Hughey; Ora A Weisz
OCRL1 function in renal epithelial membrane traffic.
American journal of physiology. Renal physiology 2010;298(2):F335-45.
2010: Christopher J Passero; Rebecca P Hughey; Thomas R Kleyman
New role for plasmin in sodium homeostasis.
Current opinion in nephrology and hypertension 2010;19(1):13-9.
2009: Polly E Mattila; Carol L Kinlough; Jennifer R Bruns; Ora A Weisz; Rebecca P Hughey
MUC1 traverses apical recycling endosomes along the biosynthetic pathway in polarized MDCK cells.
Biological chemistry 2009;390(7):551-6.
2009: Thomas R Kleyman; Rebecca P Hughey
Plasmin and sodium retention in nephrotic syndrome.
Journal of the American Society of Nephrology : JASN 2009;20(2):233-4.
2008: Marcelo D Carattino; Rebecca P Hughey; Thomas R Kleyman
Proteolytic processing of the epithelial sodium channel gamma subunit has a dominant role in channel activation.
The Journal of biological chemistry 2008;283(37):25290-5.
2008: Matthew H Lowry; Brian P McAllister; Jyh-Chang Jean; Lou Ann S Brown; Rebecca P Hughey; William W Cruikshank; Sal Amar; Edgar Lucey; Kathleen Braun; Pamela Johnson; Thomas N Wight; Martin Joyce-Brady
Lung lining fluid glutathione attenuates IL-13-induced asthma.
American journal of respiratory cell and molecular biology 2008;38(5):509-16.
2008: Marcelo D Carattino; Christopher J Passero; Carlos A Steren; Ahmad B Maarouf; Joseph M Pilewski; Mike M Myerburg; Rebecca P Hughey; Thomas R Kleyman
Defining an inhibitory domain in the alpha-subunit of the epithelial sodium channel.
American journal of physiology. Renal physiology 2008;294(1):F47-52.
2007: Gunhild M Mueller; Ossama B Kashlan; James B Bruns; Ahmad B Maarouf; Meir Aridor; Thomas R Kleyman; Rebecca P Hughey
Epithelial sodium channel exit from the endoplasmic reticulum is regulated by a signal within the carboxyl cytoplasmic domain of the alpha subunit.
The Journal of biological chemistry 2007;282(46):33475-83.
2007: Rebecca P Hughey; Thomas R Kleyman
Functional cross talk between ENaC and pendrin.
American journal of physiology. Renal physiology 2007;293(5):F1439-40.
2007: Ossama B Kashlan; Gunhild M Mueller; Mohammad Z Qamar; Paul A Poland; Annette Ahner; Ronald C Rubenstein; Rebecca P Hughey; Jeffrey L Brodsky; Thomas R Kleyman
Small heat shock protein alphaA-crystallin regulates epithelial sodium channel expression.
The Journal of biological chemistry 2007;282(38):28149-56.
2007: Rebecca P Hughey; Marcelo D Carattino; Thomas R Kleyman
Role of proteolysis in the activation of epithelial sodium channels.
Current opinion in nephrology and hypertension 2007;16(5):444-50.
2007: Shaohu Sheng; Ahmad B Maarouf; James B Bruns; Rebecca P Hughey; Thomas R Kleyman
Functional role of extracellular loop cysteine residues of the epithelial Na+ channel in Na+ self-inhibition.
The Journal of biological chemistry 2007;282(28):20180-90.
2007: Christine Rondanino; Raul Rojas; Wily G Ruiz; Exing Wang; Rebecca P Hughey; Kenneth W Dunn; gerard apodaca
RhoB-dependent modulation of postendocytic traffic in polarized Madin-Darby canine kidney cells.
Traffic (Copenhagen, Denmark) 2007;8(7):932-49.
2007: James B Bruns; Marcelo D Carattino; Shaohu Sheng; Ahmad B Maarouf; Ora A Weisz; Joseph M Pilewski; Rebecca P Hughey; Thomas R Kleyman
Epithelial Na+ channels are fully activated by furin- and prostasin-dependent release of an inhibitory peptide from the gamma-subunit.
The Journal of biological chemistry 2007;282(9):6153-60.
2006: Thomas R Kleyman; Mike M Myerburg; Rebecca P Hughey
Regulation of ENaCs by proteases: An increasingly complex story.
Kidney international 2006;70(8):1391-2.
2006: Tetsuji Morimoto; Wen Liu; Craig Woda; Marcelo D Carattino; Yuan Wei; Rebecca P Hughey; gerard apodaca; Lisa M Satlin; Thomas R Kleyman
Mechanism underlying flow stimulation of sodium absorption in the mammalian collecting duct.
American journal of physiology. Renal physiology 2006;291(3):F663-9.
2006: Marcelo D Carattino; Shaohu Sheng; James B Bruns; Joseph M Pilewski; Rebecca P Hughey; Thomas R Kleyman
The epithelial Na+ channel is inhibited by a peptide derived from proteolytic processing of its alpha subunit.
The Journal of biological chemistry 2006;281(27):18901-7.
2006: Shaohu Sheng; Marcelo D Carattino; James B Bruns; Rebecca P Hughey; Thomas R Kleyman
Furin cleavage activates the epithelial Na+ channel by relieving Na+ self-inhibition.
American journal of physiology. Renal physiology 2006;290(6):F1488-96.
2006: Carol L Kinlough; Rebecca J McMahan; Paul A Poland; James B Bruns; Keri L Harkleroad; Richard J Stremple; Ossama B Kashlan; Kelly M Weixel; Ora A Weisz; Rebecca P Hughey
Recycling of MUC1 is dependent on its palmitoylation.
The Journal of biological chemistry 2006;281(17):12112-22.
2006: Beth A Potter; Rebecca P Hughey; Ora A Weisz
Role of N- and O-glycans in polarized biosynthetic sorting.
American journal of physiology. Cell physiology 2006;290(1):C1-C10.
2005: Katja Engelmann; Carol L Kinlough; Stefan Müller; Hani Razawi; Stephan E Baldus; Rebecca P Hughey; Franz-Georg Hanisch
Transmembrane and secreted MUC1 probes show trafficking-dependent changes in O-glycan core profiles.
Glycobiology 2005;15(11):1111-24.
2005: Carol L Kinlough; Paul A Poland; James B Bruns; Rebecca P Hughey
Gamma-glutamyltranspeptidase: disulfide bridges, propeptide cleavage, and activation in the endoplasmic reticulum.
Methods in enzymology 2005;401():426-49.
2004: Carol L Kinlough; Paul A Poland; James B Bruns; Keri L Harkleroad; Rebecca P Hughey
MUC1 membrane trafficking is modulated by multiple interactions.
The Journal of biological chemistry 2004;279(51):53071-7.
2004: Rebecca P Hughey; James B Bruns; Carol L Kinlough; Thomas R Kleyman
Distinct pools of epithelial sodium channels are expressed at the plasma membrane.
The Journal of biological chemistry 2004;279(47):48491-4.
2004: Rebecca P Hughey; James B Bruns; Carol L Kinlough; Keri L Harkleroad; Qiusheng Tong; Marcelo D Carattino; John P Johnson; James Stockand; Thomas R Kleyman
Epithelial sodium channels are activated by furin-dependent proteolysis.
The Journal of biological chemistry 2004;279(18):18111-4.
2003: James B Bruns; Baofeng Hu; Yoon J Ahn; Shaohu Sheng; Rebecca P Hughey; Thomas R Kleyman
Multiple epithelial Na+ channel domains participate in subunit assembly.
American journal of physiology. Renal physiology 2003;285(4):F600-9.
2003: Rebecca P Hughey; Gunhild M Mueller; James B Bruns; Carol L Kinlough; Paul A Poland; Keri L Harkleroad; Marcelo D Carattino; Thomas R Kleyman
Maturation of the epithelial Na+ channel involves proteolytic processing of the alpha- and gamma-subunits.
The Journal of biological chemistry 2003;278(39):37073-82.
2000: Y Altschuler; Carol L Kinlough; Paul A Poland; James B Bruns; gerard apodaca; Ora A Weisz; Rebecca P Hughey
Clathrin-mediated endocytosis of MUC1 is modulated by its glycosylation state.
Molecular biology of the cell 2000;11(3):819-31.
2000: JR Henkel; Gregory A Gibson; Paul A Poland; Mark A Ellis; Rebecca P Hughey; Ora A Weisz
Influenza M2 proton channel activity selectively inhibits trans-Golgi network release of apical membrane and secreted proteins in polarized Madin-Darby canine kidney cells.
The Journal of cell biology 2000;148(3):495-504.
1997: Selim M Arcasoy; Joseph Latoche; M Gondor; simon simon watkins; RA Henderson; Rebecca P Hughey; Olivera J Finn; Joseph M Pilewski
MUC1 and other sialoglycoconjugates inhibit adenovirus-mediated gene transfer to epithelial cells.
American journal of respiratory cell and molecular biology 1997;17(4):422-35.
1997: John Lavelle; H O Negrete; Paul A Poland; Carol L Kinlough; S D Meyers; Rebecca P Hughey; Mark L Zeidel
Low permeabilities of MDCK cell monolayers: a model barrier epithelium.
The American journal of physiology 1997;273(1 Pt 2):F67-75.
1997: Selim M Arcasoy; Joseph Latoche; M Gondor; RA Henderson; Rebecca P Hughey; Olivera J Finn; Joseph M Pilewski
The effects of sialoglycoconjugates on adenovirus-mediated gene transfer to epithelial cells in vitro and in human airway xenografts.
Chest 1997;111(6 Suppl):142S-143S.
1997: Paul A Poland; Carol L Kinlough; MD Rokaw; J Magarian-Blander; Olivera J Finn; Rebecca P Hughey
Differential glycosylation of MUC1 in tumors and transfected epithelial and lymphoblastoid cell lines.
Glycoconjugate journal 1997;14(1):89-96.
1996: J Magarian-Blander; Rebecca P Hughey; Carol L Kinlough; Paul A Poland; Olivera J Finn
Differential expression of MUC1 on transfected cell lines influences its recognition by MUC1 specific T cells.
Glycoconjugate journal 1996;13(5):749-56.
1994: Martin Joyce-Brady; Yuji K Takahashi; SM Oakes; Arun K Rishi; R A Levine; Carol L Kinlough; Rebecca P Hughey
Synthesis and release of amphipathic gamma-glutamyl transferase by the pulmonary alveolar type 2 cell. Its redistribution throughout the gas exchange portion of the lung indicates a new role for surfactant.
The Journal of biological chemistry 1994;269(19):14219-26.
1994: J A Prezioso; Rebecca P Hughey; N Wang; K M Damodaran; William D Bloomer
Gamma-glutamyltranspeptidase expression regulates the growth-inhibitory activity of the anti-tumor prodrug gamma-L-glutaminyl-4-hydroxy-3-iodobenzene.
International journal of cancer. Journal international du cancer 1994;56(6):874-9.
1993: R D Scott; Rebecca P Hughey; Norman P Curthoys
Role of apical and basolateral secretion in turnover of glutathione in LLC-PK1 cells.
The American journal of physiology 1993;265(5 Pt 2):F723-8.
1993: R A Altman; A V Orr; Carl F Lagenaur; Norman P Curthoys; Rebecca P Hughey
Expression of rat renal gamma-glutamyltranspeptidase in LLC-PK1 cells as a model for apical targeting.
Biochemistry 1993;32(14):3822-8.
1989: T C Blochberger; J M Sabatine; Y C Lee; Rebecca P Hughey
O-linked glycosylation of rat renal gamma-glutamyltranspeptidase adjacent to its membrane anchor domain.
The Journal of biological chemistry 1989;264(34):20718-22.
1986: R A Altman; Rebecca P Hughey
The identification of two subcellular sites for cleavage of gamma-glutamyltranspeptidase propeptide.
Biochemistry international 1986;13(6):1009-17.
1986: Rebecca P Hughey; R A Altman; W J Wells; K A Curto
Evidence for stable homodimers and heterodimers of gamma-glutamyltranspeptidase subunits under protein-denaturing conditions.
Biochimica et biophysica acta 1986;874(2):150-9.
1981: F W Bregar; Rebecca P Hughey; Norman P Curthoys
Rat renal gamma-glutamyltransferase activity: a reaction of glutamine synthetase.
Canadian journal of biochemistry 1981;59(1):54-9.
1980: Rebecca P Hughey; B B Rankin; Norman P Curthoys
Acute acidosis and renal arteriovenous differences of glutamine in normal and adrenalectomized rats.
The American journal of physiology 1980;238(3):F199-204.