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Guenter Huhle

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Christoph Engel; Frank M Brunkhorst; Hans-Georg Bone; Reinhard Brunkhorst; Herwig Gerlach; Stefan Grond; Matthias Gruendling; Guenter Huhle; Ulrich Jaschinski; Stefan John; Konstantin Mayer; Michael Oppert; Derk Olthoff; Michael Quintel; Maximilian Ragaller; Rolf Rossaint; Frank Stuber; Norbert Weiler; Tobias Welte; Holger Bogatsch; Christiane Hartog; Markus Loeffler; Konrad Reinhart
Epidemiology of sepsis in Germany: results from a national prospective multicenter study.
Martina Brueckmann; Ursula Hoffmann; Cathleen Engelhardt; Siegfried Lang; Kenji Fukudome; Karl K Haase; Volker Liebe; Jens J Kaden; Christian Putensen; Martin Borggrefe; Guenter Huhle
Prognostic value of platelet-derived growth factor in patients with severe sepsis.
Martina Brueckmann; Adriane Schulze Nahrup; Siegfried Lang; Thomas Bertsch; Kenji Fukudome; Volker Liebe; Jens J Kaden; Ursula Hoffmann; Martin Borggrefe; Guenter Huhle
Recombinant human activated protein C upregulates the release of soluble fractalkine from human endothelial cells.

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All Publications

2007: Christoph Engel; Frank M Brunkhorst; Hans-Georg Bone; Reinhard Brunkhorst; Herwig Gerlach; Stefan Grond; Matthias Gruendling; Guenter Huhle; Ulrich Jaschinski; Stefan John; Konstantin Mayer; Michael Oppert; Derk Olthoff; Michael Quintel; Maximilian Ragaller; Rolf Rossaint; Frank Stuber; Norbert Weiler; Tobias Welte; Holger Bogatsch; Christiane Hartog; Markus Loeffler; Konrad Reinhart
Epidemiology of sepsis in Germany: results from a national prospective multicenter study.
Intensive care medicine 2007;33(4):606-18.
2007: Martina Brueckmann; Ursula Hoffmann; Cathleen Engelhardt; Siegfried Lang; Kenji Fukudome; Karl K Haase; Volker Liebe; Jens J Kaden; Christian Putensen; Martin Borggrefe; Guenter Huhle
Prognostic value of platelet-derived growth factor in patients with severe sepsis.
Growth factors (Chur, Switzerland) 2007;25(1):15-24.
2006: Martina Brueckmann; Adriane Schulze Nahrup; Siegfried Lang; Thomas Bertsch; Kenji Fukudome; Volker Liebe; Jens J Kaden; Ursula Hoffmann; Martin Borggrefe; Guenter Huhle
Recombinant human activated protein C upregulates the release of soluble fractalkine from human endothelial cells.
British journal of haematology 2006;133(5):550-7.
2006: Martina Brueckmann; Guenter Huhle; M Max
[Mechanisms of action of recombinant human activated Protein C].
Der Anaesthesist 2006;55 Suppl 1():5-15.
2006: Ursula Hoffmann; Thomas Bertsch; Eszter Dvortsak; Claudia Liebetrau; Siegfried Lang; Volker Liebe; Guenter Huhle; Martin Borggrefe; Martina Brueckmann
Matrix-metalloproteinases and their inhibitors are elevated in severe sepsis: prognostic value of TIMP-1 in severe sepsis.
Scandinavian journal of infectious diseases 2006;38(10):867-72.
2005: Martina Brueckmann; Guenter Huhle; Siegfried Lang; Karl K Haase; Thomas Bertsch; Christel Weiss; Jens J Kaden; Christian Putensen; Martin Borggrefe; Ursula Hoffmann
Prognostic value of plasma N-terminal pro-brain natriuretic peptide in patients with severe sepsis.
Circulation 2005;112(4):527-34.
2005: Martina Brueckmann; Sarah Horn; Siegfried Lang; Kenji Fukudome; Adriane Schulze Nahrup; Ursula Hoffmann; Jens J Kaden; Martin Borggrefe; Karl K Haase; Guenter Huhle
Recombinant human activated protein C upregulates cyclooxygenase-2 expression in endothelial cells via binding to endothelial cell protein C receptor and activation of protease-activated receptor-1.
Thrombosis and haemostasis 2005;93(4):743-50.
2005: Ursula Hoffmann; Martina Brueckmann; Thomas Bertsch; Mike Wiessner; Claudia Liebetrau; Siegfried Lang; Karl K Haase; Martin Borggrefe; Guenter Huhle
Increased plasma levels of NT-proANP and NT-proBNP as markers of cardiac dysfunction in septic patients.
Clinical laboratory 2005;51(7-8):373-9.
2004: Martina Brueckmann; Christian Wolpert; Thomas Bertsch; Tim Sueselbeck; Claudia Liebetrau; Jens J Kaden; Guenter Huhle; Michael Neumaier; Martin Borggrefe; Karl K Haase
Markers of myocardial damage, tissue healing, and inflammation after radiofrequency catheter ablation of atrial tachyarrhythmias.
Journal of cardiovascular electrophysiology 2004;15(6):686-91.
2004: Martina Brueckmann; Ursula Hoffmann; Lothar de Rossi; Hans Martin Weiler; Volker Liebe; Siegfried Lang; Jens J Kaden; Martin Borggrefe; Karl K Haase; Guenter Huhle
Activated protein C inhibits the release of macrophage inflammatory protein-1-alpha from THP-1 cells and from human monocytes.
Cytokine 2004;26(3):106-13.
2004: Martina Brueckmann; Thomas Bertsch; Siegfried Lang; Tim Sueselbeck; Christian Wolpert; Jens J Kaden; Carlos Jaramillo; Guenter Huhle; Martin Borggrefe; Karl K Haase
Time course of systemic markers of inflammation in patients presenting with acute coronary syndromes.
Clinical chemistry and laboratory medicine : CCLM / FESCC 2004;42(10):1132-9.
2004: Martina Brueckmann; Thomas Bertsch; Ursula Hoffmann; Siegfried Lang; Jens J Kaden; Christian Wolpert; Guenter Huhle; Martin Borggrefe; Karl K Haase
N-terminal pro-atrial natriuretic peptide as a biochemical marker of long-term interventional success after radiofrequency catheter ablation of paroxysmal supraventricular tachyarrhythmias.
Clinical chemistry and laboratory medicine : CCLM / FESCC 2004;42(8):896-902.
2003: Martina Brueckmann; Siegfried Lang; Martin Borggrefe; Guenter Huhle; Karl K Haase
Drotrecogin alfa (activated) prolongs half-life time of messenger RNA encoding for interleukin-8 and monocyte chemoattractant protein-1.
Thrombosis and haemostasis 2003;90(6):1223-6.
2003: Karl-Georg Fischer; Volker Liebe; Renata Hudek; Lukas Piazolo; Karl K Haase; Martin Borggrefe; Guenter Huhle
Anti-hirudin antibodies alter pharmacokinetics and pharmacodynamics of recombinant hirudin.
Thrombosis and haemostasis 2003;89(6):973-82.
2003: Martina Brueckmann; Antje Marx; Hans Martin Weiler; Volker Liebe; Siegfried Lang; Jens J Kaden; Wolfgang Zieger; Martin Borggrefe; Guenter Huhle; Karl Konstantin Haase
Stabilization of monocyte chemoattractant protein-1-mRNA by activated protein C.
Thrombosis and haemostasis 2003;89(1):149-60.
2002: Volker Liebe; Martina Brückmann; Karl-Georg Fischer; Karl K Haase; Martin Borggrefe; Guenter Huhle
Biological relevance of anti-recombinant hirudin antibodies--results from in vitro and in vivo studies.
Seminars in thrombosis and hemostasis 2002;28(5):483-90.
2002: U Hoffmann; Job Harenberg; K Bauer; Guenter Huhle; Alexander R Tolle; Martin Feuring; M Christ
Bioequivalence of subcutaneous and intravenous body-weight-independent high-dose low-molecular-weight heparin Certoparin on anti-Xa, Heptest, and tissue factor pathway inhibitor activity in volunteers.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 2002;13(4):289-96.
2001: P Kaiser; Job Harenberg; Jeanine M Walenga; Guenter Huhle; Christina Giese; M Margaret Prechel; D Hoppensteadt; J Fareed
Effects of a heparin-binding protein on blood coagulation and platelet function.
Seminars in thrombosis and hemostasis 2001;27(5):495-502.
2001: Job Harenberg; L C Wang; U Hoffmann; Guenter Huhle; Martin Feuring
Laboratory diagnosis of heparin-induced thrombocytopenia type II after clearance of platelet factor 4/heparin complex.
The Journal of laboratory and clinical medicine 2001;137(6):408-13.
2001: Guenter Huhle; Volker Liebe; R Hudek; DL Heene
Anti-r-hirudin antibodies reveal clinical relevance through direct functional inactivation of r-hirudin or prolongation of r-hirudin's plasma halflife.
Thrombosis and haemostasis 2001;85(5):936-8.
2001: Job Harenberg; L Wang; U Hoffmann; Guenter Huhle; Martin Feuring
Improved laboratory confirmation of heparin-induced thrombocytopenia type II. Time course of antibodies and combination of antigen and biologic assays.
American journal of clinical pathology 2001;115(3):432-8.
2001: Job Harenberg; Ursula Hoffmann; Guenter Huhle; M Winkler; Christiane Bayerl
Cutaneous reactions to anticoagulants. Recognition and management.
American journal of clinical dermatology 2001;2(2):69-75.
2000: Guenter Huhle; Ursula Hoffmann; I Hoffmann; Volker Liebe; Job Harenberg; DL Heene
A new therapeutic option by subcutaneous recombinant hirudin in patients with heparin-induced thrombocytopenia type II: a pilot study.
Thrombosis research 2000;99(4):325-34.
2000: XH Song; Guenter Huhle; LC Wang; Job Harenberg
Quantitative determination of PEG-hirudin in human plasma using a competitive enzyme-linked immunosorbent assay.
Thrombosis research 2000;99(2):195-202.
2000: Guenter Huhle; U Hoffmann; I Hoffmann; Job Harenberg; DL Heene
[Prevention of thrombosis with subcutaneous recombinant hirudin in heparin-induced thrombocytopenia type II. A pilot study].
Deutsche medizinische Wochenschrift (1946) 2000;125(22):686-91.
2000: Job Harenberg; Guenter Huhle; LC Wang; Ursula Hoffmann; XH Song
Re-exposure to recombinant (r)-hirudin in antihirudin antibody-positive patients with a history of heparin-induced thrombocytopenia.
British journal of haematology 2000;109(2):360-3.
2000: Job Harenberg; S Koch; Christina Giese; L C Wang; Ursula Hoffmann; Guenter Huhle
Quantitation of serotonin from platelets using enzyme-immunoassay in the presence of serum from HIT-patients.
Thrombosis and haemostasis 2000;83(5):795-6.
2000: Job Harenberg; Guenter Huhle; Christina Giese; LC Wang; Martin Feuring; XH Song; Ursula Hoffmann
Determination of serotonin release from platelets by enzyme immunoassay in the diagnosis of heparin-induced thrombocytopenia.
British journal of haematology 2000;109(1):182-6.
2000: Job Harenberg; Ursula Hoffmann; Guenter Huhle; XH Song; LC Wang
Treatment of an acute flush reaction caused by subcutaneous r-hirudin with pegylated hirudin.
British journal of haematology 2000;108(3):528-30.
2000: Guenter Huhle; M Geberth; Ursula Hoffmann; DL Heene; Job Harenberg
Management of heparin-associated thrombocytopenia in pregnancy with subcutaneous r-hirudin.
Gynecologic and obstetric investigation 2000;49(1):67-9.
1999: X Song; Guenter Huhle; L Wang; Ursula Hoffmann; Job Harenberg
Generation of anti-hirudin antibodies in heparin-induced thrombocytopenic patients treated with r-hirudin.
Circulation 1999;100(14):1528-32.
1999: A Müller; Guenter Huhle; Rainer Nowack; Rainer Birck; DL Heene; Fokko J van der Woude
Serious bleeding in a haemodialysis patient treated with recombinant hirudin.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 1999;14(10):2482-3.
1999: Guenter Huhle; CB Abletshauser; N Mayer; Gottfried Weidinger; Job Harenberg; DL Heene
Reduction of platelet activity markers in type II hypercholesterolemic patients by a HMG-CoA-reductase inhibitor.
Thrombosis research 1999;95(5):229-34.
1999: Guenter Huhle; U Hoffmann; X Song; L C Wang; DL Heene; J Harenberg
Immunologic response to recombinant hirudin in HIT type II patients during long-term treatment.
British journal of haematology 1999;106(1):195-201.
1999: Job Harenberg; Guenter Huhle; L Wang; Ursula Hoffmann; Christiane Bayerl; Mohammed Kerowgan
Association of heparin-induced skin lesions, intracutaneous tests, and heparin-induced IgG.
Allergy 1999;54(5):473-7.
1999: L C Wang; Guenter Huhle; Reinhard Malsch; V Hoffmann; X L Song; Job Harenberg
Determination of heparin-induced IgG antibody in heparin-induced thrombocytopenia type II.
European journal of clinical investigation 1999;29(3):232-7.
1999: L Wang; Guenter Huhle; Reinhard Malsch; U Hoffmann; X Song; Job Harenberg
Determination of heparin-induced IgG antibody by fluorescence-linked immunofiltration assay (FLIFA).
Journal of immunological methods 1999;222(1-2):93-9.
1997: Job Harenberg; Guenter Huhle; Lukas Piazolo; Reinhard Malsch
[Low-molecular-weight heparins. The prevention and therapy of thromboembolic diseases].
Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete 1997;48(11):852-64.
1997: Job Harenberg; Guenter Huhle; Lukas Piazolo; L U Wang; DL Heene
Anticoagulation in patients with heparin-induced thrombocytopenia type II.
Seminars in thrombosis and hemostasis 1997;23(2):189-96.
1997: Job Harenberg; Guenter Huhle; Lukas Piazolo; Christina Giese; DL Heene
Long-term anticoagulation of outpatients with adverse events to oral anticoagulants using low-molecular-weight heparin.
Seminars in thrombosis and hemostasis 1997;23(2):167-72.
1997: Guenter Huhle; Job Harenberg; Reinhard Malsch; DL Heene
Monoclonal antibodies against heparin and heparinoids.
Seminars in thrombosis and hemostasis 1997;23(1):17-22.
1996: Reinhard Malsch; Job Harenberg; Lukas Piazolo; Guenter Huhle; DL Heene
Chromatographic and electrophoretic applications for the analysis of heparin and dermatan sulfate.
Journal of chromatography. B, Biomedical applications 1996;685(2):223-31.
1996: Reinhard Malsch; T Mrotzek; Guenter Huhle; Job Harenberg
Purification of the monoclonal heparin antibody H-1.18.
Journal of chromatography. A 1996;744(1-2):215-21.
1996: Job Harenberg; Reinhard Malsch; Lukas Piazolo; Guenter Huhle; DL Heene
Preferential binding of heparin to granulocytes of various species.
American journal of veterinary research 1996;57(7):1016-20.
1996: Job Harenberg; Reinhard Malsch; Lukas Piazolo; Guenter Huhle; DL Heene
Analysis of heparin binding to human leukocytes using a fluorescein-5-isothiocyanate labeled heparin fragment.
Cytometry 1996;23(1):59-66.
1996: Job Harenberg; M Jeschek; M Acker; Reinhard Malsch; Guenter Huhle; DL Heene
Effects of low-molecular-weight dermatan sulfate on coagulation, fibrinolysis and tissue factor pathway inhibitor in healthy volunteers.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 1996;7(1):49-56.
1994: Guenter Huhle; Job Harenberg; Reinhard Malsch; DL Heene
Comparison of three heparin bovine serum albumin binding methods for production of antiheparin antibodies.
Seminars in thrombosis and hemostasis 1994;20(2):193-204.