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Chi-Chung Hui

Research Profile

Chemicals & Drugs

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Zhu Juan Li; Weilun Nien; Erica Nieuwenhuis; Vijitha Puviindran; Brandon J Wainwright; Jennifer Zhang; Xiaoyun Zhang; Peter C W Kim; Chi-Chung Hui
Kif7 regulates Gli2 through Sufu-dependent and -independent functions during skin development and tumorigenesis.
Shu-Hsuan C Hsu; Chi-Chung Hui; Jay S Wunder; Xiaoyun Zhang; Steven Cheng; Benjamin A Alman
Suppressor of fused (Sufu) mediates the effect of parathyroid hormone-like hormone (Pthlh) on chondrocyte differentiation in the growth plate.
Kelvin King Lo Law; Shigeru Makino; Rong Mo; Vijitha Puviindran; Xiaoyun Zhang; Chi-Chung Hui
Antagonistic and cooperative actions of Kif7 and Sufu define graded intracellular Gli activities in Hedgehog signaling.

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2012: Zhu Juan Li; Weilun Nien; Erica Nieuwenhuis; Vijitha Puviindran; Brandon J Wainwright; Jennifer Zhang; Xiaoyun Zhang; Peter C W Kim; Chi-Chung Hui
Kif7 regulates Gli2 through Sufu-dependent and -independent functions during skin development and tumorigenesis.
Development (Cambridge, England) 2012;139(22):4152-61.
2012: Shu-Hsuan C Hsu; Chi-Chung Hui; Jay S Wunder; Xiaoyun Zhang; Steven Cheng; Benjamin A Alman
Suppressor of fused (Sufu) mediates the effect of parathyroid hormone-like hormone (Pthlh) on chondrocyte differentiation in the growth plate.
The Journal of biological chemistry 2012;287(43):36222-8.
2012: Kelvin King Lo Law; Shigeru Makino; Rong Mo; Vijitha Puviindran; Xiaoyun Zhang; Chi-Chung Hui
Antagonistic and cooperative actions of Kif7 and Sufu define graded intracellular Gli activities in Hedgehog signaling.
PloS one 2012;7(11):e50193.
2011: Shu-Hsuan C Hsu; Chi-Chung Hui; Zhu Juan Li; Jay S Wunder; Chunying Yu; Xiaoyun Zhang; Benjamin A Alman
Kif7 promotes hedgehog signaling in growth plate chondrocytes by restricting the inhibitory function of Sufu.
Development (Cambridge, England) 2011;138(17):3791-801.
2011: Shinichi Miyagawa; Jun Motoyama; Aki Murashima; Naomi Nakagata; Akiko Omori; Yoshihiko Satoh; Ryuma Haraguchi; Chi-Chung Hui; Taisen Iguchi; Daisuke Matsumaru; Gen Yamada
The role of sonic hedgehog-Gli2 pathway in the masculinization of external genitalia.
Endocrinology 2011;152(7):2894-903.
2011: Jinny J Kim; Paul S Gill; Lianne Rotin; Matthijs van Eede; R Mark Henkelman; Chi-Chung Hui; Norman D Rosenblum
Suppressor of fused controls mid-hindbrain patterning and cerebellar morphogenesis via GLI3 repressor.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(5):1825-36.
2011: Chi-Chung Hui; Stephane Angers
Gli proteins in development and disease.
Annual review of cell and developmental biology 2011;27():513-37.
2010: Leigh Coultas; Erica Nieuwenhuis; Gregory A Anderson; Jorge Cabezas; Andras Nagy; R Mark Henkelman; Chi-Chung Hui; Janet Rossant
Hedgehog regulates distinct vascular patterning events through VEGF-dependent and -independent mechanisms.
Blood 2010;116(4):653-60.
2010: J Andrew Pospisilik; Daniel Schramek; Harald SCHNIDAR; Shane J F Cronin; Nadine T Nehme; Xiaoyun Zhang; Claude Knauf; Patrice Cani; Karin Aumayr; Jelena Todoric; Martina Bayer; Arvand Haschemi; Vijitha Puviindran; Krisztina Tar; Michael Orthofer; G Gregory Neely; Georg Dietzl; Armen Manoukian; Martin Funovics; Gerhard Prager; Oswald Wagner; Dominique Ferrandon; Fritz Aberger; Chi-Chung Hui; Harald Esterbauer; Josef M Penninger
Drosophila genome-wide obesity screen reveals hedgehog as a determinant of brown versus white adipose cell fate.
Cell 2010;140(1):148-60.
2010: Keli Xu; Erica Nieuwenhuis; Brenda L Cohen; Wei Wang; Angelo J Canty; Jayne S Danska; Leigh Coultas; Janet Rossant; Megan Y J Wu; Tino D Piscione; Andras Nagy; Achim Gossler; Geoff G Hicks; Chi-Chung Hui; R Mark Henkelman; Lisa X Yu; John G Sled; Thomas Gridley; Sean E Egan
Lunatic Fringe-mediated Notch signaling is required for lung alveogenesis.
American journal of physiology. Lung cellular and molecular physiology 2010;298(1):L45-56.
2009: Ryan J Ward; Lilian Lee; Kevin Graham; Thevagi Satkunendran; Koichi Yoshikawa; Erick Ling; Lauren Harper; Ryan Austin; Erica Nieuwenhuis; Ian D Clarke; Chi-Chung Hui; Peter B Dirks
Multipotent CD15+ cancer stem cells in patched-1-deficient mouse medulloblastoma.
Cancer research 2009;69(11):4682-90.
2009: Jason E Cain; Epshita Islam; Fiona Haxho; Lin Chen; Darren Bridgewater; Erica Nieuwenhuis; Chi-Chung Hui; Norman D Rosenblum
GLI3 repressor controls nephron number via regulation of Wnt11 and Ret in ureteric tip cells.
PloS one 2009;4(10):e7313.
2009: Helen Oi-Lam Cheung; Xiaoyun Zhang; Ana Ribeiro; Rong Mo; Shigeru Makino; Vijitha Puviindran; Kelvin K L Law; James Briscoe; Chi-Chung Hui
The kinesin protein Kif7 is a critical regulator of Gli transcription factors in mammalian hedgehog signaling.
Science signaling 2009;2(76):ra29.
2007: Erica Nieuwenhuis; Paul C Barnfield; Shigeru Makino; Chi-Chung Hui
Epidermal hyperplasia and expansion of the interfollicular stem cell compartment in mutant mice with a C-terminal truncation of Patched1.
Developmental biology 2007;308(2):547-60.
2007: Mélanie Lebel; Rong Mo; Kenji Shimamura; Chi-Chung Hui
Gli2 and Gli3 play distinct roles in the dorsoventral patterning of the mouse hindbrain.
Developmental biology 2007;302(1):345-55.
2006: Jianbin Peng; Wenji Dong; Ying Chen; Rong Mo; Jan-Fang Cheng; Chi-Chung Hui; Narla Mohandas; Cheng-Han Huang
Dusty protein kinases: primary structure, gene evolution, tissue specific expression and unique features of the catalytic domain.
Biochimica et biophysica acta 2006;1759(11-12):562-72.
2006: Erica Nieuwenhuis; Jun Motoyama; Paul C Barnfield; Yoshiaki Yoshikawa; Xiaoyun Zhang; Rong Mo; Michael A Crackower; Chi-Chung Hui
Mice with a targeted mutation of patched2 are viable but develop alopecia and epidermal hyperplasia.
Molecular and cellular biology 2006;26(17):6609-22.
2006: Ming Chang Hu; Rong Mo; Sita Bhella; Christopher W Wilson; Pao-Tien Chuang; Chi-Chung Hui; Norman D Rosenblum
GLI3-dependent transcriptional repression of Gli1, Gli2 and kidney patterning genes disrupts renal morphogenesis.
Development (Cambridge, England) 2006;133(3):569-78.
2006: Kazuko Koshiba-Takeuchi; Jun K Takeuchi; Eric P Arruda; Irfan S Kathiriya; Rong Mo; Chi-Chung Hui; Deepak Srivastava; Benoit G Bruneau
Cooperative and antagonistic interactions between Sall4 and Tbx5 pattern the mouse limb and heart.
Nature genetics 2006;38(2):175-83.
2005: Chi Wa Cheng; Robert L Chow; Mélanie Lebel; Rui Sakuma; Helen Oi-Lam Cheung; Vijitha Thanabalasingham; Xiaoyun Zhang; Benoit G Bruneau; David G Birch; Chi-Chung Hui; Roderick R McInnes; Shuk Han Cheng
The Iroquois homeobox gene, Irx5, is required for retinal cone bipolar cell development.
Developmental biology 2005;287(1):48-60.
2005: Edwina McGlinn; Kelly Lammerts van Bueren; Salvatore Fiorenza; Rong Mo; Alisa M Poh; Alistair Forrest; M Bento Soares; Maria de Fatima Bonaldo; Sean M Grimmond; Chi-Chung Hui; Brandon J Wainwright; Carol Wicking
Pax9 and Jagged1 act downstream of Gli3 in vertebrate limb development.
Mechanisms of development 2005;122(11):1218-33.
2005: Danny L Costantini; Eric P Arruda; Pooja Agarwal; Kyoung-Han Kim; Yonghong Zhu; Wei Zhu; Mélanie Lebel; Chi Wa Cheng; Chong Y Park; Stephanie A Pierce; Alejandra Guerchicoff; Guido D Pollevick; Toby Y Chan; golam kabir; Shuk Han Cheng; Mansoor Husain; Charles Antzelevitch; Deepak Srivastava; Gil J Gross; Chi-Chung Hui; Peter H Backx; Benoit G Bruneau
The homeodomain transcription factor Irx5 establishes the mouse cardiac ventricular repolarization gradient.
Cell 2005;123(2):347-58.
2005: Paul C Barnfield; Xiaoyun Zhang; Vijitha Thanabalasingham; Minoru Yoshida; Chi-Chung Hui
Negative regulation of Gli1 and Gli2 activator function by Suppressor of fused through multiple mechanisms.
Differentiation; research in biological diversity 2005;73(8):397-405.
2005: Valerie P I Vidal; Marie-Christine Chaboissier; Susanne Lützkendorf; George Cotsarelis; Pleasantine Mill; Chi-Chung Hui; Nicolas Ortonne; Jean-Paul Ortonne; Andreas Schedl
Sox9 is essential for outer root sheath differentiation and the formation of the hair stem cell compartment.
Current biology : CB 2005;15(15):1340-51.
2005: Pleasantine Mill; Rong Mo; Ming Chang Hu; Lina Dagnino; Norman D Rosenblum; Chi-Chung Hui
Shh controls epithelial proliferation via independent pathways that converge on N-Myc.
Developmental cell 2005;9(2):293-303.
2005: Yumiko Imai; Keiji Kuba; Shuan Rao; Yi Huan; Feng Guo; Bin Guan; Peng Yang; Renu Sarao; Teiji Wada; Howard Leong-Poi; Michael A Crackower; Akiyoshi Fukamizu; Chi-Chung Hui; Lutz Hein; Stefan Uhlig; Arthur Slutsky; Chengyu Jiang; Josef M Penninger
Angiotensin-converting enzyme 2 protects from severe acute lung failure.
Nature 2005;436(7047):112-6.
2005: Jun K Takeuchi; Maria Mileikovskaia; Kazuko Koshiba-Takeuchi; Analeah B Heidt; Alessandro Mori; Eric P Arruda; Marina Gertsenstein; Romain Georges; Lorinda Davidson; Rong Mo; Chi-Chung Hui; R Mark Henkelman; Mona Nemer; Brian L Black; Andras Nagy; Benoit G Bruneau
Tbx20 dose-dependently regulates transcription factor networks required for mouse heart and motoneuron development.
Development (Cambridge, England) 2005;132(10):2463-74.
2005: Erica Nieuwenhuis; Chi-Chung Hui
Hedgehog signaling and congenital malformations.
Clinical genetics 2005;67(3):193-208.
2004: Karl J L Fernandes; Ian Andrew McKenzie; Pleasantine Mill; Kristen M Smith; Mahnaz Akhavan; Fanie Barnabé-Heider; Jeff Biernaskie; Adrienne Junek; Nao R Kobayashi; Jean G Toma; David R Kaplan; Patricia A Labosky; Victor Rafuse; Chi-Chung Hui; Freda D Miller
A dermal niche for multipotent adult skin-derived precursor cells.
Nature cell biology 2004;6(11):1082-93.
2004: Michael D Taylor; Xiaoyun Zhang; Ling Liu; Chi-Chung Hui; Todd G Mainprize; Stephen W Scherer; Brandon J Wainwright; David Hogg; James T Rutka
Failure of a medulloblastoma-derived mutant of SUFU to suppress WNT signaling.
Oncogene 2004;23(26):4577-83.
2003: Kinga Michno; Kata Boras-Granic; Pleasantine Mill; Chi-Chung Hui; Paul A Hamel
Shh expression is required for embryonic hair follicle but not mammary gland development.
Developmental biology 2003;264(1):153-65.
2003: Laura Buttitta; Rong Mo; Chi-Chung Hui; Chen-Ming Fan
Interplays of Gli2 and Gli3 and their requirement in mediating Shh-dependent sclerotome induction.
Development (Cambridge, England) 2003;130(25):6233-43.
2003: Mélanie Lebel; Pooja Agarwal; Chi Wa Cheng; golam kabir; Toby Y Chan; Vijitha Thanabalasingham; Xiaoyun Zhang; Dana R Cohen; Mansoor Husain; Shuk Han Cheng; Benoit G Bruneau; Chi-Chung Hui
The Iroquois homeobox gene Irx2 is not essential for normal development of the heart and midbrain-hindbrain boundary in mice.
Molecular and cellular biology 2003;23(22):8216-25.
2003: Emily K Griffiths; Otto H Sanchez; Pleasantine Mill; Connie M Krawczyk; Carlo V Hojilla; Evelyn Rubin; Marion M Nau; Rama Khokha; Stan Lipkowitz; Chi-Chung Hui; Josef M Penninger
Cbl-3-deficient mice exhibit normal epithelial development.
Molecular and cellular biology 2003;23(21):7708-18.
2003: Kazue Hashimoto-Torii; Jun Motoyama; Chi-Chung Hui; Atsushi Kuroiwa; Masato Nakafuku; Kenji Shimamura
Differential activities of Sonic hedgehog mediated by Gli transcription factors define distinct neuronal subtypes in the dorsal thalamus.
Mechanisms of development 2003;120(10):1097-111.
2003: Jun Motoyama; Ljiljana Milenkovic; Mizuho Iwama; Yayoi Shikata; Matthew P Scott; Chi-Chung Hui
Differential requirement for Gli2 and Gli3 in ventral neural cell fate specification.
Developmental biology 2003;259(1):150-61.
2003: Michael A Crackower; Nadine K Kolas; Junko Noguchi; Renu Sarao; Kazuhiro Kikuchi; Hiroyuki Kaneko; Eiji Kobayashi; Yasuhiro Kawai; Ivona Kozieradzki; Rushin Landers; Rong Mo; Chi-Chung Hui; Edward Nieves; Paula E Cohen; Lucy Osborne; Teiji Wada; Tetsuo Kunieda; Peter B Moens; Josef M Penninger
Essential role of Fkbp6 in male fertility and homologous chromosome pairing in meiosis.
Science (New York, N.Y.) 2003;300(5623):1291-5.
2003: Michael Nicolas; Anita Wolfer; Kenneth Raj; J Alain Kummer; Pleasantine Mill; Mascha van Noort; Chi-Chung Hui; Hans Clevers; G Paolo Dotto; Freddy Radtke
Notch1 functions as a tumor suppressor in mouse skin.
Nature genetics 2003;33(3):416-21.
2003: Pleasantine Mill; Rong Mo; Hong Fu; Marina Grachtchouk; Peter C W Kim; Andrzej Dlugosz; Chi-Chung Hui
Sonic hedgehog-dependent activation of Gli2 is essential for embryonic hair follicle development.
Genes & development 2003;17(2):282-94.
2002: Hong Sheng; Sara Goich; Aiqin Wang; Marina Grachtchouk; Lori Lowe; Rong Mo; Kui Lin; Frederic J de Sauvage; Hiroshi Sasaki; Chi-Chung Hui; Andrzej Dlugosz
Dissecting the oncogenic potential of Gli2: deletion of an NH(2)-terminal fragment alters skin tumor phenotype.
Cancer research 2002;62(18):5308-16.
2002: Michael D Taylor; Ling Liu; Corey Raffel; Chi-Chung Hui; Todd G Mainprize; Xiaoyun Zhang; Ron Agatep; Sharon Chiappa; Luzhang Gao; Anja Lowrance; Aihau Hao; Alisa M Goldstein; Theodora Stavrou; Stephen W Scherer; Wieslaw T Dura; Brandon J Wainwright; Jeremy A Squire; James T Rutka; David Hogg
Mutations in SUFU predispose to medulloblastoma.
Nature genetics 2002;31(3):306-10.
2001: X Meng; R Poon; Xiaoyun Zhang; Alexander Y L Cheah; Q Ding; Chi-Chung Hui; Benjamin A Alman
Suppressor of fused negatively regulates beta-catenin signaling.
The Journal of biological chemistry 2001;276(43):40113-9.
2001: Rong Mo; J H Kim; J Zhang; C Chiang; Chi-Chung Hui; Peter C W Kim
Anorectal malformations caused by defects in sonic hedgehog signaling.
The American journal of pathology 2001;159(2):765-74.
2001: J Kim; P Kim; Chi-Chung Hui
The VACTERL association: lessons from the Sonic hedgehog pathway.
Clinical genetics 2001;59(5):306-15.
2000: G Boehmelt; Irene Fialka; G Brothers; MD McGinley; Scott D Patterson; Rong Mo; Chi-Chung Hui; S Chung; Lukas A Huber; Tak W Mak; Norman N Iscove
Cloning and characterization of the murine glucosamine-6-phosphate acetyltransferase EMeg32. Differential expression and intracellular membrane association.
The Journal of biological chemistry 2000;275(17):12821-32.
2000: D R Cohen; Chi Wa Cheng; Shuk Han Cheng; Chi-Chung Hui
Expression of two novel mouse Iroquois homeobox genes during neurogenesis.
Mechanisms of development 2000;91(1-2):317-21.
2000: Marina Grachtchouk; Rong Mo; S Yu; X Zhang; H Sasaki; Chi-Chung Hui; Andrzej Dlugosz
Basal cell carcinomas in mice overexpressing Gli2 in skin.
Nature genetics 2000;24(3):216-7.
2000: S G Kimmel; Rong Mo; Chi-Chung Hui; Peter C W Kim
New mouse models of congenital anorectal malformations.
Journal of pediatric surgery 2000;35(2):227-30; discussion 230-1.
1999: A Partanen; Jun Motoyama; Chi-Chung Hui
Developmentally regulated expression of the transcriptional cofactors/histone acetyltransferases CBP and p300 during mouse embryogenesis.
The International journal of developmental biology 1999;43(6):487-94.
1999: Z Hardcastle; Chi-Chung Hui; Paul T Sharpe
The Shh signalling pathway in early tooth development.
Cellular and molecular biology (Noisy-le-Grand, France) 1999;45(5):567-78.
1998: Jun Motoyama; Jason Liu; Rong Mo; Q Ding; Martin Post; Chi-Chung Hui
Essential function of Gli2 and Gli3 in the formation of lung, trachea and oesophagus.
Nature genetics 1998;20(1):54-7.
1998: Z Hardcastle; Rong Mo; Chi-Chung Hui; Paul T Sharpe
The Shh signalling pathway in tooth development: defects in Gli2 and Gli3 mutants.
Development (Cambridge, England) 1998;125(15):2803-11.
1998: Q Ding; Jun Motoyama; S Gasca; Rong Mo; Hiroshi Sasaki; Janet Rossant; Chi-Chung Hui
Diminished Sonic hedgehog signaling and lack of floor plate differentiation in Gli2 mutant mice.
Development (Cambridge, England) 1998;125(14):2533-43.
1997: Z Yao; K Diener; XS Wang; M Zukowski; G Matsumoto; G Zhou; Rong Mo; T Sasaki; Hiroshi Nishina; Chi-Chung Hui; Tse-Hua Tan; J P Woodgett; J M Penninger
Activation of stress-activated protein kinases/c-Jun N-terminal protein kinases (SAPKs/JNKs) by a novel mitogen-activated protein kinase kinase.
The Journal of biological chemistry 1997;272(51):32378-83.
1997: Brenda Cohen; Arash Bashirullah; Lina Dagnino; C Campbell; WW Fisher; Ching Ching Leow; E Whiting; D Ryan; DL Zinyk; Gabrielle L Boulianne; Chi-Chung Hui; Brenda L Gallie; RA Phillips; Howard D Lipshitz; Sean E Egan
Fringe boundaries coincide with Notch-dependent patterning centres in mammals and alter Notch-dependent development in Drosophila.
Nature genetics 1997;16(3):283-8.
1997: A Suzuki; José Luis de la Pompa; Raza Hakem; Andrew Elia; R Yoshida; Rong Mo; Hiroshi Nishina; T Chuang; Andrew Wakeham; Annick Itie; W Koo; P Billia; Alexandra Ho; M Fukumoto; Chi-Chung Hui; Tak W Mak
Brca2 is required for embryonic cellular proliferation in the mouse.
Genes & development 1997;11(10):1242-52.
1996: Raza Hakem; José Luis de la Pompa; C Sirard; Rong Mo; Minna Woo; Anne Hakem; Andrew Wakeham; J Potter; Armin Reitmair; Filio Billia; E Firpo; Chi-Chung Hui; J Roberts; Janet Rossant; Tak W Mak
The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse.
Cell 1996;85(7):1009-23.
1995: Z Gong; Chi-Chung Hui; Choy L Hew
Presence of isl-1-related LIM domain homeobox genes in teleost and their similar patterns of expression in brain and spinal cord.
The Journal of biological chemistry 1995;270(7):3335-45.