Username

Password

Preview

Sign-in free and Explore the Exciting World of BiomedExperts:

Over 1.500.000 Profiles
More than 1.800 Organizations worldwide
State of the Art Network Visualizations

Manage your own Profile
Locate Experts in your Country/Region
Locate Experts in your 1. and 2. Level Network
Connect to Experts Worldwide

NetworkView

Tom Huizinga

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Disorders

Chemicals & Drugs

Physiology

Genes & Molecular Sequences

Anatomy

Synovial Membrane

Concepts & Ideas

Sign-in to see full Profile

Sign-in to see all Coauthors

Publications

TOP 3
Vliet Vlieland Theodora P M; Huizinga Tom W J
Quality indicators in rheumatology: valid for whom?
Emmer Bart J; van der Bijl A Egon; Huizinga Tom W J; Breedveld Ferdinand C; Steens Stefan C A; Th Bosma Gerlof P; van Buchem Mark A; van der Grond Jeroen
Brain involvement in rheumatoid arthritis: A magnetic resonance spectroscopy study.
Wang Jun; Huizinga Tom W J; Toes Rene E M
De novo generation and enhanced suppression of human CD4+CD25+ regulatory T cells by retinoic acid.

Sign-in to see all Publications

Sign in free and see...

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the visualized research activity
of experts around the globe

Sign-in to see more

Geonetwork of Tom Huizinga (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

Sign-in to see more

All Publications

2009: Vliet Vlieland Theodora P M; Huizinga Tom W J
Quality indicators in rheumatology: valid for whom?
Annals of the rheumatic diseases 2009;68(12):1797-9.
2009: Emmer Bart J; van der Bijl A Egon; Huizinga Tom W J; Breedveld Ferdinand C; Steens Stefan C A; Th Bosma Gerlof P; van Buchem Mark A; van der Grond Jeroen
Brain involvement in rheumatoid arthritis: A magnetic resonance spectroscopy study.
Arthritis and rheumatism 2009;60(11):3190-5.
2009: Wang Jun; Huizinga Tom W J; Toes Rene E M
De novo generation and enhanced suppression of human CD4+CD25+ regulatory T cells by retinoic acid.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(6):4119-26.
2009: Huizinga Tom W J; Gröndal Gerdur
Shared symptoms in rheumatic diseases: a blessing or a curse?
Arthritis and rheumatism 2009;60(9):2547-9.
2009: van der Woude Diane; Huizinga Tom W J
Every shared epitope allele for itself?
Nature reviews. Rheumatology 2009;5(9):477-8.
2009: Kooloos Wouter M; Guchelaar Henk-Jan; Huizinga Tom W J; Wessels Judith A M
Comment on: Investigation of candidate polymorphisms and disease activity in rheumatoid arthritis patients on methotrexate.
Rheumatology (Oxford, England) 2009;48(9):1176-7; author reply 1177.
2009: Kooloos Wouter M; Wessels Judith A M; van der Straaten Tahar; Huizinga Tom W J; Guchelaar Henk-Jan
Criteria for the selection of single nucleotide polymorphisms in pathway pharmacogenetics: TNF inhibitors as a case study.
Drug discovery today 2009;14(17-18):837-44.
2009: van der Linden Michael P M; van der Woude Diane; Ioan-Facsinay Andreea; Levarht E W Nivine; Stoeken-Rijsbergen Gerrie; Huizinga Tom W J; Toes René E M; van der Helm-van Mil Annette H M
Value of anti-modified citrullinated vimentin and third-generation anti-cyclic citrullinated peptide compared with second-generation anti-cyclic citrullinated peptide and rheumatoid factor in predicting disease outcome in undifferentiated arthritis and rheumatoid arthritis.
Arthritis and rheumatism 2009;60(8):2232-41.
2009: van der Linden Michael P M; Feitsma Anouk L; le Cessie Saskia; Kern Marlena; Olsson Lina M; Raychaudhuri Soumya; Begovich Ann B; Chang Monica; Catanese Joseph J; Kurreeman Fina A S; van Nies Jessica; van der Heijde Désirée M; Gregersen Peter K; Huizinga Tom W J; Toes René E M; van der Helm-Van Mil Annette H M
Association of a single-nucleotide polymorphism in CD40 with the rate of joint destruction in rheumatoid arthritis.
Arthritis and rheumatism 2009;60(8):2242-7.
2009: van der Woude Diane; Young Adam; Jayakumar Keeranur; Mertens Bart J; Toes René E M; van der Heijde Désirée; Huizinga Tom W J; van der Helm-van Mil Annette H M
Prevalence of and predictive factors for sustained disease-modifying antirheumatic drug-free remission in rheumatoid arthritis: results from two large early arthritis cohorts.
Arthritis and rheumatism 2009;60(8):2262-71.
2009: Han Wanda G H; Schuurhuis Danita H; Fu Nathalie; Camps Marcel; van Duivenvoorde Leonie M; Louis-Plence Pascale; Franken Kees L M C; Huizinga Tom W J; Melief Cornelis J M; Toes René E M; Ossendorp Ferry
DC-induced CD8(+) T-cell response is inhibited by MHC class II-dependent DX5(+)CD4(+) Treg.
European journal of immunology 2009;39(7):1765-73.
2009: Teng Y K O; Levarht E W N; Toes Rene E M; Huizinga Tom W J; van Laar Jacob M
Residual inflammation after rituximab treatment is associated with sustained synovial plasma cell infiltration and enhanced B cell repopulation.
Annals of the rheumatic diseases 2009;68(6):1011-6.
2009: Daha Nina A; Kurreeman Fina A S; Marques Rute B; Stoeken-Rijsbergen Gerrie; Verduijn Willem; Huizinga Tom W J; Toes René E M
Confirmation of STAT4, IL2/IL21, and CTLA4 polymorphisms in rheumatoid arthritis.
Arthritis and rheumatism 2009;60(5):1255-60.
2009: Klarenbeek Naomi B; Allaart Cornelia F; Kerstens Pit J S M; Huizinga Tom W J; Dijkmans Ben A C
The BeSt story: on strategy trials in rheumatoid arthritis.
Current opinion in rheumatology 2009;21(3):291-8.
2009: van der Woude Diane; Houwing-Duistermaat Jeanine J; Toes René E M; Huizinga Tom W J; Thomson Wendy; Worthington Jane; van der Helm-van Mil Annette H M; de Vries René R P
Quantitative heritability of anti-citrullinated protein antibody-positive and anti-citrullinated protein antibody-negative rheumatoid arthritis.
Arthritis and rheumatism 2009;60(4):916-23.
2009: van Bergen Jeroen; Kooy-Winkelaar Engelina M C; van Dongen Henrike; van Gaalen Floris A; Thompson Allan; Huizinga Tom W J; Feltkamp Mariet C W; Toes René E M; Koning Frits
Functional killer Ig-like receptors on human memory CD4+ T cells specific for cytomegalovirus.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(7):4175-82.
2009: Toes Rene E M; Huizinga Tom W J
Autoimmune responses in the rheumatoid synovium.
PLoS medicine 2009;6(1):e9.
2008: Heemstra Karen A; Toes Rene E; Sepers Jan; Pereira Alberto M; Corssmit Eleonora P; Huizinga Tom W J; Romijn Johannes A; Smit Johannes W
Rituximab in relapsing Graves' disease, a phase II study.
European journal of endocrinology / European Federation of Endocrine Societies 2008;159(5):609-15.
2008: Albers H M; Kurreeman F A S; Houwing-Duistermaat J J; Brinkman D M C; Kamphuis S S M; Girschick H J; Wouters C; Van Rossum M A J; Verduijn W; Toes R E M; Huizinga T W J; Schilham M W; ten Cate R
The TRAF1/C5 region is a risk factor for polyarthritis in juvenile idiopathic arthritis.
Annals of the rheumatic diseases 2008;67(11):1578-80.
2008: de Poorter Jolanda J; Hoeben Rob C; Obermann Willem R; Huizinga Tom W J; Nelissen Rob G H H
Gene therapy for the treatment of hip prosthesis loosening: adverse events in a phase 1 clinical study.
Human gene therapy 2008;19(10):1029-38.
2008: Ioan-Facsinay Andreea; Willemze Annemiek; Robinson David B; Peschken Christine A; Markland Janet; van der Woude Diane; Elias Brenda; Ménard Henri A; Newkirk Marianna; Fritzler Marvin J; Toes René E M; Huizinga Tom W J; El-Gabalawy Hani S
Marked differences in fine specificity and isotype usage of the anti-citrullinated protein antibody in health and disease.
Arthritis and rheumatism 2008;58(10):3000-8.
2008: Kurreeman F A S; Rocha D; Houwing-Duistermaat J; Vrijmoet S; Teixeira V H; Migliorini P; Balsa A; Westhovens R; Barrera P; Alves H; Vaz C; Fernandes M; Pascual-Salcedo D; Michou L; Bombardieri S; Radstake T; van Riel P; van de Putte L; Lopes-Vaz A; Prum B; Bardin T; Gut I; Cornelis F; Huizinga T W J; Petit-Teixeira E; Toes R E M;
Replication of the tumor necrosis factor receptor-associated factor 1/complement component 5 region as a susceptibility locus for rheumatoid arthritis in a European family-based study.
Arthritis and rheumatism 2008;58(9):2670-4.
2008: van der Helm-van Mil Annette H M; Padyukov Leonid; Toes René E M; Klareskog Lars; Huizinga Tom W J
Genome-wide single-nucleotide polymorphism studies in rheumatology: Hype or hope?
Arthritis and rheumatism 2008;58(9):2591-7.
2008: van der Helm-van Mil Annette H M; Detert Jacqueline; le Cessie Saskia; Filer Andrew; Bastian Hans; Burmester Gerd R; Huizinga Tom W J; Raza Karim
Validation of a prediction rule for disease outcome in patients with recent-onset undifferentiated arthritis: moving toward individualized treatment decision-making.
Arthritis and rheumatism 2008;58(8):2241-7.
2008: Chang Monica; Rowland Charles M; Garcia Veronica E; Schrodi Steven J; Catanese Joseph J; van der Helm-van Mil Annette H M; Ardlie Kristin G; Amos Christopher I; Criswell Lindsey A; Kastner Daniel L; Gregersen Peter K; Kurreeman Fina A S; Toes Rene E M; Huizinga Tom W J; Seldin Michael F; Begovich Ann B
A large-scale rheumatoid arthritis genetic study identifies association at chromosome 9q33.2.
PLoS genetics 2008;4(6):e1000107.
2008: Wang Jun; van Dongen Henrike; Scherer Hans Ulrich; Huizinga Tom W J; Toes Rene E M
Suppressor activity among CD4+,CD25++ T cells is discriminated by membrane-bound tumor necrosis factor alpha.
Arthritis and rheumatism 2008;58(6):1609-18.
2008: van der Helm-van Mil A H M; van der Kooij S M; Allaart C F; Toes R E M; Huizinga T W J
A high body mass index has a protective effect on the amount of joint destruction in small joints in early rheumatoid arthritis.
Annals of the rheumatic diseases 2008;67(6):769-74.
2008: Emmer B J; Steup-Beekman G M; Steens S C A; Huizinga T W J; van Buchem M A; van der Grond J
Correlation of magnetization transfer ratio histogram parameters with neuropsychiatric systemic lupus erythematosus criteria and proton magnetic resonance spectroscopy: association of magnetization transfer ratio peak height with neuronal and cognitive dysfunction.
Arthritis and rheumatism 2008;58(5):1451-7.
2008: de Vries-Bouwstra J K; Goekoop-Ruiterman Y P M; Verpoort K N; Schreuder G M T; Ewals J A P M; Terwiel J P; Ronday H K; Kerstens P J S M; Toes R E M; de Vries R R P; Breedveld F C; Dijkmans B A C; Huizinga T W J; Allaart C F
Progression of joint damage in early rheumatoid arthritis: association with HLA-DRB1, rheumatoid factor, and anti-citrullinated protein antibodies in relation to different treatment strategies.
Arthritis and rheumatism 2008;58(5):1293-8.
2008: Tchetverikov I; Huizinga T W J; van der Helm-van Mil A H M
Biomarkers in the prediction of radiographic progression in early rheumatoid arthritis: comment on the article by Young-Min et al.
Arthritis and rheumatism 2008;58(5):1558-9; author reply 1559.
2008: Gelinck L B S; van der Bijl A E; Beyer W E P; Visser L G; Huizinga T W J; van Hogezand R A; Rimmelzwaan G F; Kroon F P
The effect of anti-tumour necrosis factor alpha treatment on the antibody response to influenza vaccination.
Annals of the rheumatic diseases 2008;67(5):713-6.
2008: van der Woude D; Huizinga T W J
Translating basic research into clinical rheumatology.
Best practice & research. Clinical rheumatology 2008;22(2):299-310.
2008: van der Kooij S M; Wessels J A M; Huizinga T W J; Guchelaar H-J
Comment on: The pharmacogenetics of methotrexate.
Rheumatology (Oxford, England) 2008;47(4):557; author reply 5557-8.
2008: Rood M J; Vermeer M H; Huizinga T W J
Hyperpigmentation of the skin due to hydroxychloroquine.
Scandinavian journal of rheumatology 2008;37(2):158.
2008: van Mierlo Geertje J D; Scherer Hans U; Hameetman Marjolijn; Morgan Mary E; Flierman Roelof; Huizinga Tom W J; Toes René E M
Cutting edge: TNFR-shedding by CD4+CD25+ regulatory T cells inhibits the induction of inflammatory mediators.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(5):2747-51.
2008: Rood Maarten J; Huizinga Tom W J
Vascular compromise of a finger due to tenosynovitis.
The Journal of rheumatology 2008;35(2):354.
2008: Huizinga Tom W J
A European perspective on the 50th anniversary of Arthritis & Rheumatism.
Arthritis and rheumatism 2008;58(2 Suppl):S136-9.
2008: de Poorter Jolanda J; Hoeben Rob C; Hogendoorn Simone; Mautner Vivien; Ellis John; Obermann Wim R; Huizinga Tom W J; Nelissen Rob G H H
Gene therapy and cement injection for restabilization of loosened hip prostheses.
Human gene therapy 2008;19(1):83-95.
2008: Tchetverikov I; Kraan M C; van El B; Hanemaaijer R; DeGroot J; Huizinga T W J
Leflunomide and methotrexate reduce levels of activated matrix metalloproteinases in complexes with alpha2 macroglobulin in serum of rheumatoid arthritis patients.
Annals of the rheumatic diseases 2008;67(1):128-30.
2007: Feitsma Anouk L; Worthington Jane; van der Helm-van Mil Annette H M; Plant Darren; Thomson Wendy; Ursum Jennie; van Schaardenburg Dirkjan; van der Horst-Bruinsma Irene E; van Rood Jon J; Huizinga Tom W J; Toes René E M; de Vries René R P
Protective effect of noninherited maternal HLA-DR antigens on rheumatoid arthritis development.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(50):19966-70.
2007: Teng Y K Onno; Levarht E W Nivine; Hashemi Mojtaba; Bajema Ingeborg M; Toes René E M; Huizinga Tom W J; van Laar Jacob M
Immunohistochemical analysis as a means to predict responsiveness to rituximab treatment.
Arthritis and rheumatism 2007;56(12):3909-18.
2007: Verpoort K N; Cheung K; Ioan-Facsinay A; van der Helm-van Mil A H M; de Vries-Bouwstra J K; Allaart C F; Drijfhout J W; de Vries R R P; Breedveld F C; Huizinga T W J; Pruijn G J M; Toes R E M
Fine specificity of the anti-citrullinated protein antibody response is influenced by the shared epitope alleles.
Arthritis and rheumatism 2007;56(12):3949-52.
2007: van der Woude Diane; Huizinga Tom W J
The battle between anti-cyclic citrullinated peptide and rheumatoid factor tests--a winner at last?
Nature clinical practice. Rheumatology 2007;3(12):696-7.
2007: Steenvoorden M M C; Toes R E M; Ronday H K; Huizinga T W J; Degroot J
RAGE activation induces invasiveness of RA fibroblast-like synoviocytes in vitro.
Clinical and experimental rheumatology 2007;25(5):740-2.
2007: Kurreeman Fina A S; Padyukov Leonid; Marques Rute B; Schrodi Steven J; Seddighzadeh Maria; Stoeken-Rijsbergen Gerrie; van der Helm-van Mil Annette H M; Allaart Cornelia F; Verduyn Willem; Houwing-Duistermaat Jeanine; Alfredsson Lars; Begovich Ann B; Klareskog Lars; Huizinga Tom W J; Toes Rene E M
A candidate gene approach identifies the TRAF1/C5 region as a risk factor for rheumatoid arthritis.
PLoS medicine 2007;4(9):e278.
2007: Verpoort K N; Papendrecht-van der Voort E A M; van der Helm-van Mil A H M; Jol-van der Zijde C M; van Tol M J D; Drijfhout J W; Breedveld F C; de Vries R R P; Huizinga T W J; Toes R E M
Association of smoking with the constitution of the anti-cyclic citrullinated peptide response in the absence of HLA-DRB1 shared epitope alleles.
Arthritis and rheumatism 2007;56(9):2913-8.
2007: Timmer Trieneke C G; Baltus Belinda; Vondenhoff Mark; Huizinga Tom W J; Tak Paul P; Verweij Cornelis L; Mebius Reina E; van der Pouw Kraan Tineke C T M
Inflammation and ectopic lymphoid structures in rheumatoid arthritis synovial tissues dissected by genomics technology: identification of the interleukin-7 signaling pathway in tissues with lymphoid neogenesis.
Arthritis and rheumatism 2007;56(8):2492-502.
2007: van Duivenvoorde Leonie M; Han Wanda G H; Bakker Aleida M; Louis-Plence Pascale; Charbonnier Louis-Marie; Apparailly Florence; van der Voort Ellen I H; Jorgensen Christian; Huizinga Tom W J; Toes René E M
Immunomodulatory dendritic cells inhibit Th1 responses and arthritis via different mechanisms.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(3):1506-15.
2007: de Poorter Jolanda J; Lipinski Kai S; Nelissen Rob G H H; Huizinga Tom W J; Hoeben Rob C
Optimization of short-term transgene expression by sodium butyrate and ubiquitous chromatin opening elements (UCOEs).
The journal of gene medicine 2007;9(8):639-48.
2007: de Vries-Bouwstra J K; Goekoop-Ruiterman Y P M; Wesoly J; Hulsmans H J; de Craen A J M; Breedveld F C; Dijkmans B A C; Allaart C F; Huizinga T W J
Ex vivo interleukin 1 receptor antagonist production on lipopolysaccharide stimulation is associated with rheumatoid arthritis and with joint damage.
Annals of the rheumatic diseases 2007;66(8):1033-7.
2007: Sigurdsson Snaevar; Padyukov Leonid; Kurreeman Fina A S; Liljedahl Ulrika; Wiman Ann-Christin; Alfredsson Lars; Toes René; Rönnelid Johan; Klareskog Lars; Huizinga Tom W J; Alm Gunnar; Syvänen Ann-Christine; Rönnblom Lars
Association of a haplotype in the promoter region of the interferon regulatory factor 5 gene with rheumatoid arthritis.
Arthritis and rheumatism 2007;56(7):2202-10.
2007: Feitsma A L; Toes R E M; Begovich A B; Chokkalingam A P; de Vries R R P; Huizinga T W J; van der Helm-van Mil A H M
Risk of progression from undifferentiated arthritis to rheumatoid arthritis: the effect of the PTPN22 1858T-allele in anti-citrullinated peptide antibody positive patients.
Rheumatology (Oxford, England) 2007;46(7):1092-5.
2007: van Montfoort Nadine; de Jong Judith M H; Schuurhuis Danita H; van der Voort Ellen I H; Camps Marcel G M; Huizinga Tom W J; van Kooten Cees; Daha Mohamed R; Verbeek J Sjef; Ossendorp Ferry; Toes René E M
A novel role of complement factor C1q in augmenting the presentation of antigen captured in immune complexes to CD8+ T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(12):7581-6.
2007: van der Helm-van Mil Annette H M; Huizinga Tom W J; de Vries René R P; Toes René E M
Emerging patterns of risk factor make-up enable subclassification of rheumatoid arthritis.
Arthritis and rheumatism 2007;56(6):1728-35.
2007: Wessels Judith A M; van der Kooij Sjoerd M; le Cessie Saskia; Kievit Wietske; Barerra Pilar; Allaart Cornelia F; Huizinga Tom W J; Guchelaar Henk-Jan;
A clinical pharmacogenetic model to predict the efficacy of methotrexate monotherapy in recent-onset rheumatoid arthritis.
Arthritis and rheumatism 2007;56(6):1765-75.
2007: Thabet Mohamed M; Wesoly J; Slagboom P E; Toes R E M; Huizinga T W J
FCRL3 promoter 169 CC homozygosity is associated with susceptibility to rheumatoid arthritis in Dutch Caucasians.
Annals of the rheumatic diseases 2007;66(6):803-6.
2007: van Dongen Henrike; van Aken Jill; Lard Leroy R; Visser Karen; Ronday H Karel; Hulsmans Harry M J; Speyer Irene; Westedt Marie-Louise; Peeters André J; Allaart Cornelia F; Toes René E M; Breedveld Ferdinand C; Huizinga Tom W J
Efficacy of methotrexate treatment in patients with probable rheumatoid arthritis: a double-blind, randomized, placebo-controlled trial.
Arthritis and rheumatism 2007;56(5):1424-32.
2007: Linn-Rasker S P; van der Helm-van Mil A H M; Breedveld F C; Huizinga T W J
Arthritis of the large joints - in particular, the knee - at first presentation is predictive for a high level of radiological destruction of the small joints in rheumatoid arthritis.
Annals of the rheumatic diseases 2007;66(5):646-50.
2007: Rood Maarten J; Lavrijsen Sjan P M; Huizinga Tom W J
Acitretin-related ossification.
The Journal of rheumatology 2007;34(4):837-8.
2007: Wesoly J; Hu X; Thabet M M; Chang M; Uh H; Allaart C F; Toes R E M; Houwing-Duistermaat J J; Begovich A B; Huizinga T W J
The 620W allele is the PTPN22 genetic variant conferring susceptibility to RA in a Dutch population.
Rheumatology (Oxford, England) 2007;46(4):617-21.
2007: van der Bijl A E; Emmer B J; Breedveld F C; Middelkoop H A M; Jurgens C K; van Buchem M A; Huizinga T W J; van der Grond J
Advanced magnetic resonance imaging of the brain in patients treated with TNF-alpha blocking agents.
Clinical and experimental rheumatology 2007;25(2):301-4.
2007: Steenvoorden M M C; Bank R A; Ronday H K; Toes R E M; Huizinga T W J; DeGroot J
Fibroblast-like synoviocyte-chondrocyte interaction in cartilage degradation.
Clinical and experimental rheumatology 2007;25(2):239-45.
2007: van der Helm-van Mil A H; Kurreeman F A; Toes R E; Huizinga T W
Association of tumor necrosis factor alpha polymorphism and radiographic progression in rheumatoid arthritis: comment on the article by Khanna et al.
Arthritis and rheumatism 2007;56(3):1032-3; author reply1033-4.
2007: Pincus Theodore; Huizinga Tom W J; Yazici Yusuf
N-of-1 trial of low-dose methotrexate and/or prednisolone in lieu of anti-CCP, MRI, or ultrasound, as first option in suspected rheumatoid arthritis?
The Journal of rheumatology 2007;34(2):250-2.
2007: van der Straaten R J H M; Wessels Judith A M; de Vries-Bouwstra Jeska K; Goekoop-Ruiterman Yvonne P M; Allaart Cornelia F; Bogaartz Judith; Tiller Marco; Huizinga Tom W J; Guchelaar Henk-Jan
Exploratory analysis of four polymorphisms in human GGH and FPGS genes and their effect in methotrexate-treated rheumatoid arthritis patients.
Pharmacogenomics 2007;8(2):141-50.
2007: Kooloos Wouter M; de Jong Dirk J; Huizinga Tom W J; Guchelaar Henk-Jan
Potential role of pharmacogenetics in anti-TNF treatment of rheumatoid arthritis and Crohn's disease.
Drug discovery today 2007;12(3-4):125-31.
2007: van der Helm-van Mil Annette H M; le Cessie Saskia; van Dongen Henrike; Breedveld Ferdinand C; Toes René E M; Huizinga Tom W J
A prediction rule for disease outcome in patients with recent-onset undifferentiated arthritis: how to guide individual treatment decisions.
Arthritis and rheumatism 2007;56(2):433-40.
2007: van der Helm-van Mil Annette H M; Verpoort Kirsten N; le Cessie Saskia; Huizinga Tom W J; de Vries René R P; Toes René E M
The HLA-DRB1 shared epitope alleles differ in the interaction with smoking and predisposition to antibodies to cyclic citrullinated peptide.
Arthritis and rheumatism 2007;56(2):425-32.
2007: Wang Jun; Ioan-Facsinay Andreea; van der Voort Ellen I H; Huizinga Tom W J; Toes René E M
Transient expression of FOXP3 in human activated nonregulatory CD4+ T cells.
European journal of immunology 2007;37(1):129-38.
2007: Monraats P S; Kurreeman F A S; Pons D; Sewgobind V D K D; de Vries F R; Zwinderman A H; de Maat M P M; Doevendans P A; de Winter R J; Tio R A; Waltenberger J; Huizinga T W J; Eefting D; Quax P H A; Frants R R; van der Laarse A; van der Wall E E; Jukema J W
Interleukin 10: a new risk marker for the development of restenosis after percutaneous coronary intervention.
Genes and immunity 2007;8(1):44-50.
2007: Tolboom Tanja C A; Huizinga Tom W J
In vitro matrigel fibroblast invasion assay.
Methods in molecular medicine 2007;135():413-21.
2007: Teng Y K Onno; Verburg Robert J; Verpoort Kirsten N; Diepenhorst Gwendolyn M P; Bajema Ingeborg M; van Tol Maarten J D; Jol-van der Zijde Els C M; Toes Rene E M; Huizinga Tom W J; van Laar Jacob M
Differential responsiveness to immunoablative therapy in refractory rheumatoid arthritis is associated with level and avidity of anti-cyclic citrullinated protein autoantibodies: a case study.
Arthritis research & therapy 2007;9(5):R106.
2006: Emmer Bart J; van der Grond Jeroen; Steup-Beekman Gerda M; Huizinga Tom W J; van Buchem Mark A
Selective involvement of the amygdala in systemic lupus erythematosus.
PLoS medicine 2006;3(12):e499.
2006: Verpoort K N; Jol-van der Zijde C M; Papendrecht-van der Voort E A M; Ioan-Facsinay A; Drijfhout J W; van Tol M J D; Breedveld F C; Huizinga T W J; Toes R E M
Isotype distribution of anti-cyclic citrullinated peptide antibodies in undifferentiated arthritis and rheumatoid arthritis reflects an ongoing immune response.
Arthritis and rheumatism 2006;54(12):3799-808.
2006: van Dunné F M; de Craen A J M; Helmerhorst F M; Huizinga T W J; Westendorp R G J
Interleukin-10 promoter polymorphisms in male and female fertility and fecundity.
Genes and immunity 2006;7(8):688-92.
2006: de Poorter Jolanda J; Obermann Willem R; Huizinga Tom W J; Nelissen Rob G H H
Arthrography in loosened hip prostheses. Assessment of possibilities for intra-articular therapy.
Joint, bone, spine : revue du rhumatisme 2006;73(6):684-90.
2006: de Jong Judith M H; Schuurhuis Danita H; Ioan-Facsinay Andreea; Welling Mick M; Camps Marcel G M; van der Voort Ellen I H; Huizinga Tom W J; Ossendorp Ferry; Verbeek J Sjef; Toes René E M
Dendritic cells, but not macrophages or B cells, activate major histocompatibility complex class II-restricted CD4+ T cells upon immune-complex uptake in vivo.
Immunology 2006;119(4):499-506.
2006: Thabet Mohamed M; Huizinga Tom W J
Drug evaluation: apratastat, a novel TACE/MMP inhibitor for rheumatoid arthritis.
Current opinion in investigational drugs (London, England : 2000) 2006;7(11):1014-9.
2006: Wesoly Joanna; Wessels Judith A M; Guchelaar Henk-Jan; Huizinga Tom W J
Genetic markers of treatment response in rheumatoid arthritis.
Current rheumatology reports 2006;8(5):369-77.
2006: Emmer Bart J; Steens Stefan C A; Steup-Beekman Gerda M; van der Grond J; Admiraal-Behloul Faiza; Olofsen Hans; Bosma Gerlof P Th; Ouwendijk Wiljan J N; Huizinga Tom W J; van Buchem Mark A
Detection of change in CNS involvement in neuropsychiatric SLE: a magnetization transfer study.
Journal of magnetic resonance imaging : JMRI 2006;24(4):812-6.
2006: Steup-Beekman Gerda M; Gahrmann Bastiaan M A; Steens Stefan C A; van Buchem Mark A; Huizinga Tom W J
Seasonal variation of primary neuropsychiatric systemic lupus erythematosus.
The Journal of rheumatology 2006;33(9):1913-4; author reply 1914.
2006: Charbonnier Louis-Marie; van Duivenvoorde Leonie M; Apparailly Florence; Cantos Céline; Han Wanda G H; Noël Danièle; Duperray Christophe; Huizinga Tom W J; Toes René E M; Jorgensen Christian; Louis-Plence Pascale
Immature dendritic cells suppress collagen-induced arthritis by in vivo expansion of CD49b+ regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(6):3806-13.
2006: Wessels Judith A M; Kooloos Wouter M; De Jonge Robert; De Vries-Bouwstra Jeska K; Allaart Cornelia F; Linssen Annelies; Collee Gerard; De Sonnaville Peter; Lindemans Jan; Huizinga Tom W J; Guchelaar Henk-Jan
Relationship between genetic variants in the adenosine pathway and outcome of methotrexate treatment in patients with recent-onset rheumatoid arthritis.
Arthritis and rheumatism 2006;54(9):2830-9.
2006: van Winkelen P; van Denderen J S; Vossen C Y; Huizinga T W J; Dekker F W
How evidence-based are advertisements in journals regarding the subspecialty of rheumatology?
Rheumatology (Oxford, England) 2006;45(9):1154-7.
2006: van der Helm-van Mil Annette H M; Kern M; Gregersen Peter K; Huizinga Tom W J
Variation in radiologic joint destruction in rheumatoid arthritis differs between monozygotic and dizygotic twins and pairs of unrelated patients.
Arthritis and rheumatism 2006;54(6):2028-30.
2006: de Vries René R P; Huizinga Tom W J; Toes René E M
HLA and RA revisited: citrullinated food for the SE hypothesis, the DR6 effect, and NIMA.
Human immunology 2006;67(6):454-9.
2006: de Jong Judith M H; Schuurhuis Danita H; Ioan-Facsinay Andreea; van der Voort Ellen I H; Huizinga Tom W J; Ossendorp Ferry; Toes René E M; Verbeek J Sjef
Murine Fc receptors for IgG are redundant in facilitating presentation of immune complex derived antigen to CD8+ T cells in vivo.
Molecular immunology 2006;43(13):2045-50.
2006: Huizinga Tom W J; Arend Sandra M
Is the tuberculin skin test an accurate method of detecting tuberculosis in patients with rheumatoid arthritis?
Nature clinical practice. Rheumatology 2006;2(4):188-9.
2006: van der Helm-van Mil Annette H M; Verpoort Kirsten N; Breedveld Ferdinand C; Huizinga Tom W J; Toes René E M; de Vries René R P
The HLA-DRB1 shared epitope alleles are primarily a risk factor for anti-cyclic citrullinated peptide antibodies and are not an independent risk factor for development of rheumatoid arthritis.
Arthritis and rheumatism 2006;54(4):1117-21.
2006: Wessels Judith A M; de Vries-Bouwstra Jeska K; Heijmans Bas T; Slagboom P Eline; Goekoop-Ruiterman Yvonne P M; Allaart Cornelia F; Kerstens Pit J S M; van Zeben Derkjen; Breedveld Ferdinand C; Dijkmans Ben A C; Huizinga Tom W J; Guchelaar Henk-Jan
Efficacy and toxicity of methotrexate in early rheumatoid arthritis are associated with single-nucleotide polymorphisms in genes coding for folate pathway enzymes.
Arthritis and rheumatism 2006;54(4):1087-95.
2006: Steenvoorden M M C; van der Helm-van Mil A H M; Stoeken G; Bank R A; Devries R R P; Huizinga T W J; Degroot J; Toes R E M
The RAGE G82S polymorphism is not associated with rheumatoid arthritis independently of HLA-DRB1*0401.
Rheumatology (Oxford, England) 2006;45(4):488-90.
2006: Tolboom T C A; Zhang Y-H; Henriquez N V; Nelissen R G H H; Toes R E M; Noteborn M H M; Huizinga T W J
Fibroblast-like synoviocytes from patients with rheumatoid arthritis are more sensitive to apoptosis induced by the viral protein, apoptin, than fibroblast-like synoviocytes from trauma patients.
Clinical and experimental rheumatology 2006;24(2):142-7.
2006: Linn-Rasker S P; van der Helm-van Mil A H M; van Gaalen F A; Kloppenburg M; de Vries R R P; le Cessie S; Breedveld F C; Toes R E M; Huizinga T W J
Smoking is a risk factor for anti-CCP antibodies only in rheumatoid arthritis patients who carry HLA-DRB1 shared epitope alleles.
Annals of the rheumatic diseases 2006;65(3):366-71.
2006: Vermeulen M; Huizinga T W J
[Neurological or psychiatric symptoms in patients with systemic lupus erythematosus (SLE): terminological problems, pathogenesis, diagnosis and therapy]
Nederlands tijdschrift voor geneeskunde 2006;150(7):367-72.
2006: Vencovský Jií; Huizinga Tom W J
Rheumatoid arthritis: the goal rather than the health-care provider is key.
Lancet 2006;367(9509):450-2.
2006: Schoe Abraham; van der Laan-Baalbergen Nicole E; Huizinga Tom W J; Breedveld Ferdinand C; van Laar Jacob M
Pulmonary fibrosis in a patient with rheumatoid arthritis treated with adalimumab.
Arthritis and rheumatism 2006;55(1):157-9.
2006: Steenvoorden Marjan M C; Huizinga Tom W J; Verzijl Nicole; Bank Ruud A; Ronday H Karel; Luning Hilco A F; Lafeber Floris P J G; Toes René E M; DeGroot Jeroen
Activation of receptor for advanced glycation end products in osteoarthritis leads to increased stimulation of chondrocytes and synoviocytes.
Arthritis and rheumatism 2006;54(1):253-63.
2006: van Aken J; van Dongen H; le Cessie S; Allaart C F; Breedveld F C; Huizinga T W J
Comparison of long term outcome of patients with rheumatoid arthritis presenting with undifferentiated arthritis or with rheumatoid arthritis: an observational cohort study.
Annals of the rheumatic diseases 2006;65(1):20-5.
2006: Steenvoorden Marjan M C; Tolboom Tanja C A; van der Pluijm Gabri; Löwik Clemens; Visser Cornelis P J; DeGroot Jeroen; Gittenberger-DeGroot Adriana C; DeRuiter Marco C; Wisse Bert J; Huizinga Tom W J; Toes René E M
Transition of healthy to diseased synovial tissue in rheumatoid arthritis is associated with gain of mesenchymal/fibrotic characteristics.
Arthritis research & therapy 2006;8(6):R165.
2006: Maes Piet; Clement Jan; Groeneveld Paul H P; Colson Paul; Huizinga Tom W J; Van Ranst Marc
Tumor necrosis factor-alpha genetic predisposing factors can influence clinical severity in nephropathia epidemica.
Viral immunology 2006;19(3):558-64.
2006: van der Helm-van Mil Annette H M; Breedveld Ferdinand C; Huizinga Tom W J
Aspects of early arthritis. Definition of disease states in early arthritis: remission versus minimal disease activity.
Arthritis research & therapy 2006;8(4):216.
2006: Steens Stefan C A; Bosma Gerlof P T H; Steup-Beekman Gerda M; le Cessie Saskia; Huizinga Tom W J; van Buchem Mark A
Association between microscopic brain damage as indicated by magnetization transfer imaging and anticardiolipin antibodies in neuropsychiatric lupus.
Arthritis research & therapy 2006;8(2):R38.
2005: van Laar Jacob M; Huizinga Tom W J
Tweaking microtubules to treat scleroderma.
PLoS medicine 2005;2(12):e415.
2005: Huizinga Tom W J; Landewé Robert B M
Early aggressive therapy in rheumatoid arthritis: a 'window of opportunity'?
Nature clinical practice. Rheumatology 2005;1(1):2-3.
2005: Steens Stefan C A; Steup-Beekman Gerda M; Bosma Gerlof P Th; Admiraal-Behloul Faiza; Olofsen Hans; Doornbos Joost; Huizinga Tom W J; van Buchem Mark A
The effect of corticosteroid medication on quantitative MR parameters of the brain.
AJNR. American journal of neuroradiology 2005;26(10):2475-80.
2005: Huizinga Tom W J; Amos Christopher I; van der Helm-van Mil Annette H M; Chen Wei; van Gaalen Floris A; Jawaheer Damini; Schreuder Geziena M T; Wener Mark; Breedveld Ferdinand C; Ahmad Naila; Lum Raymond F; de Vries Rene R P; Gregersen Peter K; Toes Rene E M; Criswell Lindsey A
Refining the complex rheumatoid arthritis phenotype based on specificity of the HLA-DRB1 shared epitope for antibodies to citrullinated proteins.
Arthritis and rheumatism 2005;52(11):3433-8.
2005: van Gaalen Floris; Ioan-Facsinay Andreea; Huizinga Tom W J; Toes René E M
The devil in the details: the emerging role of anticitrulline autoimmunity in rheumatoid arthritis.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(9):5575-80.
2005: Steeghs N; Huizinga T W J; Dik H
Bilateral hydropneumothoraces in a patient with pulmonary rheumatoid nodules during treatment with methotrexate.
Annals of the rheumatic diseases 2005;64(11):1661-2.
2005: de Poorter Jolanda J; Tolboom Tanja C A; Rabelink Martijn J W E; Pieterman Elsbet; Hoeben Rob C; Nelissen Rob G H H; Huizinga Tom W J
Towards gene therapy in prosthesis loosening: efficient killing of interface cells by gene-directed enzyme prodrug therapy with nitroreductase and the prodrug CB1954.
The journal of gene medicine 2005;7(11):1421-8.
2005: Verpoort Kirsten N; van Gaalen Floris A; van der Helm-van Mil Annette H M; Schreuder Geziena M T; Breedveld Ferdinand C; Huizinga Tom W J; de Vries Rene R P; Toes Rene E M
Association of HLA-DR3 with anti-cyclic citrullinated peptide antibody-negative rheumatoid arthritis.
Arthritis and rheumatism 2005;52(10):3058-62.
2005: Zhernakova Alexandra; Eerligh Peter; Barrera Pilar; Wesoly Joanna Z; Huizinga Tom W J; Roep Bart O; Wijmenga Cisca; Koeleman Bobby P C
CTLA4 is differentially associated with autoimmune diseases in the Dutch population.
Human genetics 2005;118(1):58-66.
2005: van Gaalen F A; Visser H; Huizinga T W J
A comparison of the diagnostic accuracy and prognostic value of the first and second anti-cyclic citrullinated peptides (CCP1 and CCP2) autoantibody tests for rheumatoid arthritis.
Annals of the rheumatic diseases 2005;64(10):1510-2.
2005: Wesoly J; van der Helm-van Mil A H M; Toes R E; Chokkalingam A P; Carlton V E H; Begovich A B; Huizinga T W J
Association of the PTPN22 C1858T single-nucleotide polymorphism with rheumatoid arthritis phenotypes in an inception cohort.
Arthritis and rheumatism 2005;52(9):2948-50.
2005: van der Helm-van Mil Annette H M; Huizinga Tom W J; Schreuder Geziena M Th; Breedveld Ferdinand C; de Vries René R P; Toes René E M
An independent role of protective HLA class II alleles in rheumatoid arthritis severity and susceptibility.
Arthritis and rheumatism 2005;52(9):2637-44.
2005: Wesoly J; Toes R E M; Slagboom P E; Huizinga T W J
RUNX1 intronic SNP is not associated with rheumatoid arthritis susceptibility in Dutch Caucasians.
Rheumatology (Oxford, England) 2005;44(9):1196.
2005: Riyazi Naghmeh; Kurreeman Fina A S; Huizinga Tom W J; Dekker Friedo W; Stoeken-Rijsbergen Gerrie; Kloppenburg Margreet
The role of interleukin 10 promoter polymorphisms in the susceptibility of distal interphalangeal osteoarthritis.
The Journal of rheumatology 2005;32(8):1571-5.
2005: Tolboom Tanja C A; van der Helm-Van Mil Annette H M; Nelissen Rob G H H; Breedveld Ferdinand C; Toes René E M; Huizinga Tom W J
Invasiveness of fibroblast-like synoviocytes is an individual patient characteristic associated with the rate of joint destruction in patients with rheumatoid arthritis.
Arthritis and rheumatism 2005;52(7):1999-2002.
2005: van der Slot Annemarie J; van Dura Ernst A; de Wit Elly C; De Groot Jeroen; Huizinga Tom W J; Bank Ruud A; Zuurmond Anne-Marie
Elevated formation of pyridinoline cross-links by profibrotic cytokines is associated with enhanced lysyl hydroxylase 2b levels.
Biochimica et biophysica acta 2005;1741(1-2):95-102.
2005: Riyazi Naghmeh; Slagboom Eline; de Craen Anton J M; Meulenbelt Ingrid; Houwing-Duistermaat Jeanine J; Kroon Herman M; van Schaardenburg Dirkjan; Rosendaal Frits R; Breedveld Ferdinand C; Huizinga Tom W J; Kloppenburg Margreet
Association of the risk of osteoarthritis with high innate production of interleukin-1beta and low innate production of interleukin-10 ex vivo, upon lipopolysaccharide stimulation.
Arthritis and rheumatism 2005;52(5):1443-50.
2005: Drynda Andreas; Quax Paul H A; Neumann Manfred; van der Laan Willemijn H; Pap Géza; Drynda Susanne; Meinecke Ingmar; Kekow Joern; Neumann Wolfram; Huizinga Tom W J; Naumann Michael; König Wolfgang; Pap Thomas
Gene transfer of tissue inhibitor of metalloproteinases-3 reverses the inhibitory effects of TNF-alpha on Fas-induced apoptosis in rheumatoid arthritis synovial fibroblasts.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(10):6524-31.
2005: van der Helm-van Mil Annette H M; Wesoly Joanna Z; Huizinga Tom W J
Understanding the genetic contribution to rheumatoid arthritis.
Current opinion in rheumatology 2005;17(3):299-304.
2005: Tchetverikov I; Lohmander L S; Verzijl N; Huizinga T W J; TeKoppele J M; Hanemaaijer R; DeGroot J
MMP protein and activity levels in synovial fluid from patients with joint injury, inflammatory arthritis, and osteoarthritis.
Annals of the rheumatic diseases 2005;64(5):694-8.
2005: van der Slot-Verhoeven Annemarie J; van Dura Ernst A; Attema Joline; Blauw Bep; Degroot Jeroen; Huizinga Tom W J; Zuurmond Anne-Marie; Bank Ruud A
The type of collagen cross-link determines the reversibility of experimental skin fibrosis.
Biochimica et biophysica acta 2005;1740(1):60-7.
2005: van Oosterhout M; Levarht E W N; Sont J K; Huizinga T W J; Toes R E M; van Laar J M
Clinical efficacy of infliximab plus methotrexate in DMARD naive and DMARD refractory rheumatoid arthritis is associated with decreased synovial expression of TNF alpha and IL18 but not CXCL12.
Annals of the rheumatic diseases 2005;64(4):537-43.
2005: Flierman Roelof; Witteveen Hendrik J; van der Voort Ellen I H; Huizinga Tom W J; de Vries René R P; Fibbe Willem E; Toes René E M; van Laar Jacob M
Control of systemic B cell-mediated autoimmune disease by nonmyeloablative conditioning and major histocompatibility complex-mismatched allogeneic bone marrow transplantation.
Blood 2005;105(7):2991-4.
2005: Schippers Emile F; van 't Veer Cornelis; van Voorden Sjaak; Martina Cerithsa A E; Huizinga Tom W J; le Cessie Saskia; van Dissel Jaap T
IL-10 and toll-like receptor-4 polymorphisms and the in vivo and ex vivo response to endotoxin.
Cytokine 2005;29(5):215-28.
2005: Kasperkovitz Pia V; Timmer Trieneke C G; Smeets Tom J; Verbeet Nicolette L; Tak Paul P; van Baarsen Lisa G M; Baltus Belinda; Huizinga Tom W J; Pieterman Elsbet; Fero Mike; Firestein Gary S; van der Pouw Kraan Tineke C T M; Verweij Cornelis L
Fibroblast-like synoviocytes derived from patients with rheumatoid arthritis show the imprint of synovial tissue heterogeneity: evidence of a link between an increased myofibroblast-like phenotype and high-inflammation synovitis.
Arthritis and rheumatism 2005;52(2):430-41.
2005: Hoffman I E A; Peene I; Cebecauer L; Isenberg D; Huizinga T W J; Union A; Meheus L; De Bosschere K; Hulstaert F; Veys E M; De Keyser F
Presence of rheumatoid factor and antibodies to citrullinated peptides in systemic lupus erythematosus.
Annals of the rheumatic diseases 2005;64(2):330-2.
2005: Morgan Mary E; van Bilsen Jolanda H M; Bakker Aleida M; Heemskerk Bianca; Schilham Marco W; Hartgers Franca C; Elferink Berendina G; van der Zanden Linda; de Vries René R P; Huizinga Tom W J; Ottenhoff Tom H M; Toes René E M
Expression of FOXP3 mRNA is not confined to CD4+CD25+ T regulatory cells in humans.
Human immunology 2005;66(1):13-20.
2005: Seelen M A; van der Bijl E A; Trouw L A; Zuiverloon T C M; Munoz J R; Fallaux-van den Houten F C; Schlagwein N; Daha M R; Huizinga T W J; Roos A
A role for mannose-binding lectin dysfunction in generation of autoantibodies in systemic lupus erythematosus.
Rheumatology (Oxford, England) 2005;44(1):111-9.
2005: de Vries René R P; Huizinga Tom W J; Toes René E M
Redefining the HLA and RA association: to be or not to be anti-CCP positive.
Journal of autoimmunity 2005;25 Suppl():21-5.
2005: van der Helm-van Mil Annette H M; Verpoort Kirsten N; Breedveld Ferdinand C; Toes René E M; Huizinga Tom W J
Antibodies to citrullinated proteins and differences in clinical progression of rheumatoid arthritis.
Arthritis research & therapy 2005;7(5):R949-58.
2004: van Bilsen Jolanda H M; van Dongen Henrike; Lard Leroy R; van der Voort Ellen I H; Elferink Diënne G; Bakker Aleida M; Miltenburg André M M; Huizinga Tom W J; de Vries René R P; Toes René E M
Functional regulatory immune responses against human cartilage glycoprotein-39 in health vs. proinflammatory responses in rheumatoid arthritis.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(49):17180-5.
2004: de Jong Z; Munneke M; Zwinderman A H; Kroon H M; Ronday K H; Lems W F; Dijkmans B A C; Breedveld F C; Vliet Vlieland T P M; Hazes J M W; Huizinga T W J
Long term high intensity exercise and damage of small joints in rheumatoid arthritis.
Annals of the rheumatic diseases 2004;63(11):1399-405.
2004: Moraes M O; Pacheco A G; Schonkeren J J M; Vanderborght P R; Nery J A C; Santos A R; Moraes M E; Moraes J R; Ottenhoff T H M; Sampaio E P; Huizinga T W J; Sarno E N
Interleukin-10 promoter single-nucleotide polymorphisms as markers for disease susceptibility and disease severity in leprosy.
Genes and immunity 2004;5(7):592-5.
2004: Polderman M C A; le Cessie S; Huizinga T W J; Pavel S
Efficacy of UVA-1 cold light as an adjuvant therapy for systemic lupus erythematosus.
Rheumatology (Oxford, England) 2004;43(11):1402-4.
2004: van Duivenvoorde Leonie M; Louis-Plence Pascale; Apparailly Florence; van der Voort Ellen I H; Huizinga Tom W J; Jorgensen Christian; Toes René E M
Antigen-specific immunomodulation of collagen-induced arthritis with tumor necrosis factor-stimulated dendritic cells.
Arthritis and rheumatism 2004;50(10):3354-64.
2004: Bosma G P Th; Steens S C A; Petropoulos Helen; Admiraal-Behloul Faiza; van den Haak A; Doornbos J; Huizinga T W J; Brooks William M; Harville Aaron; Sibbitt Wilmer L; van Buchem M A
Multisequence magnetic resonance imaging study of neuropsychiatric systemic lupus erythematosus.
Arthritis and rheumatism 2004;50(10):3195-202.
2004: Fransen J; Laan R F J M; Van Der Laar M A F J; Huizinga T W J; Van Riel P L C M
Influence of guideline adherence on outcome in a randomised controlled trial on the efficacy of methotrexate with folate supplementation in rheumatoid arthritis.
Annals of the rheumatic diseases 2004;63(10):1222-6.
2004: van der Helm-van Mil A H M; Dieudé P; Schonkeren J J M; Cornélis F; Huizinga T W J
No association between tumour necrosis factor receptor type 2 gene polymorphism and rheumatoid arthritis severity: a comparison of the extremes of phenotypes.
Rheumatology (Oxford, England) 2004;43(10):1232-4.
2004: Verpoort K N; van Dongen H; Allaart C F; Toes R E M; Breedveld F C; Huizinga T W J
Undifferentiated arthritis--disease course assessed in several inception cohorts.
Clinical and experimental rheumatology 2004;22(5 Suppl 35):S12-7.
2004: van den Biggelaar Anita H J; Huizinga Tom W J; de Craen Anton J M; Gussekloo Jacobijn; Heijmans Bastiaan T; Frölich Marijke; Westendorp Rudi G J
Impaired innate immunity predicts frailty in old age. The Leiden 85-plus study.
Experimental gerontology 2004;39(9):1407-14.
2004: Steens S C A; Admiraal-Behloul F; Bosma G P Th; Steup-Beekman G M; Olofsen H; Le Cessie S; Huizinga T W J; Van Buchem M A
Selective gray matter damage in neuropsychiatric lupus.
Arthritis and rheumatism 2004;50(9):2877-81.
2004: Hoffman I E A; Peene I; Meheus L; Huizinga T W J; Cebecauer L; Isenberg D; De Bosschere K; Hulstaert F; Veys E M; De Keyser F
Specific antinuclear antibodies are associated with clinical features in systemic lupus erythematosus.
Annals of the rheumatic diseases 2004;63(9):1155-8.
2004: van Dunné F M; Lard L R; Rook D; Helmerhorst F M; Huizinga T W J
Miscarriage but not fecundity is associated with progression of joint destruction in rheumatoid arthritis.
Annals of the rheumatic diseases 2004;63(8):956-60.
2004: Kurreeman Fina A S; Schonkeren Joris J M; Heijmans Bastiaan T; Toes Rene E M; Huizinga Tom W J
Transcription of the IL10 gene reveals allele-specific regulation at the mRNA level.
Human molecular genetics 2004;13(16):1755-62.
2004: Jansen L M A; van der Horst-Bruinsma I E; van Schaardenburg D; Lard L R; Hazes J M W; Huizinga T W J; Dijkmans B A C
Comparison of the baseline disease activity of early oligo- and polyarthritis in sequential years.
Clinical and experimental rheumatology 2004;22(4):447-52.
2004: van der Slot Annemarie J; Zuurmond Anne-Marie; van den Bogaerdt Antoon J; Ulrich Magda M W; Middelkoop Esther; Boers Willem; Karel Ronday H; DeGroot Jeroen; Huizinga Tom W J; Bank Ruud A
Increased formation of pyridinoline cross-links due to higher telopeptide lysyl hydroxylase levels is a general fibrotic phenomenon.
Matrix biology : journal of the International Society for Matrix Biology 2004;23(4):251-7.
2004: van Gaalen Floris A; van Aken Jill; Huizinga Tom W J; Schreuder Geziena M Th; Breedveld Ferdinand C; Zanelli Eric; van Venrooij Walther J; Verweij Cornelis L; Toes René E M; de Vries René R P
Association between HLA class II genes and autoantibodies to cyclic citrullinated peptides (CCPs) influences the severity of rheumatoid arthritis.
Arthritis and rheumatism 2004;50(7):2113-21.
2004: Huizinga Tom W J; Pisetsky David S; Kimberly Robert P
Associations, populations, and the truth: recommendations for genetic association studies in Arthritis & Rheumatism.
Arthritis and rheumatism 2004;50(7):2066-71.
2004: Tchetverikov I; Ronday H K; Van El B; Kiers G H; Verzijl N; TeKoppele J M; Huizinga T W J; DeGroot J; Hanemaaijer R
MMP profile in paired serum and synovial fluid samples of patients with rheumatoid arthritis.
Annals of the rheumatic diseases 2004;63(7):881-3.
2004: Vanderborght Patrícia R; Matos Haroldo J; Salles Ana M; Vasconcellos Sidra E; Silva-Filho Valcemir F; Huizinga Tom W J; Ottenhoff Tom H M; Sampaio Elisabeth P; Sarno Euzenir N; Santos Adalberto R; Moraes Milton O
Single nucleotide polymorphisms (SNPs) at -238 and -308 positions in the TNFalpha promoter: clinical and bacteriological evaluation in leprosy.
International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association 2004;72(2):143-8.
2004: de Groot C J M; Jansen M W J C; Bertina R M; Schonkeren J J M; Helmerhorst F M; Huizinga T W J
Interleukin 10-2849AA genotype protects against pre-eclampsia.
Genes and immunity 2004;5(4):313-4.
2004: Van Den Biggelaar Anita H J; De Craen Anton J M; Gussekloo Jacobijn; Huizinga Tom W J; Heijmans Bastiaan T; Frölich Marijke; Kirkwood Tom B L; Westendorp Rudi G J
Inflammation underlying cardiovascular mortality is a late consequence of evolutionary programming.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(9):1022-4.
2004: Meulenbelt Ingrid; Seymour Albert B; Nieuwland Marja; Huizinga Tom W J; van Duijn Cornelia M; Slagboom P Eline
Association of the interleukin-1 gene cluster with radiographic signs of osteoarthritis of the hip.
Arthritis and rheumatism 2004;50(4):1179-86.
2004: Tolboom T C A; Huidekoper A L; Kramer I M; Pieterman E; Toes R E M; Huizinga T W J
Correlation between expression of CD44 splice variant v8-v9 and invasiveness of fibroblast-like synoviocytes in an in vitro system.
Clinical and experimental rheumatology 2004;22(2):158-64.
2004: van Gaalen F A; Linn-Rasker S P; van Venrooij W J; de Jong B A; Breedveld F C; Verweij C L; Toes R E M; Huizinga T W J
Autoantibodies to cyclic citrullinated peptides predict progression to rheumatoid arthritis in patients with undifferentiated arthritis: a prospective cohort study.
Arthritis and rheumatism 2004;50(3):709-15.
2004: van Aken J; Lard L R; le Cessie S; Hazes J M W; Breedveld F C; Huizinga T W J
Radiological outcome after four years of early versus delayed treatment strategy in patients with recent onset rheumatoid arthritis.
Annals of the rheumatic diseases 2004;63(3):274-9.
2004: van Gaalen Floris A; Toes Rene E M; Ditzel Henrik J; Schaller Monica; Breedveld Ferdinand C; Verweij Cor L; Huizinga Tom W J
Association of autoantibodies to glucose-6-phosphate isomerase with extraarticular complications in rheumatoid arthritis.
Arthritis and rheumatism 2004;50(2):395-9.
2004: Lard Leroy R; Roep Bart O; Toes Rene E M; Huizinga Thomas W J
Enhanced concentrations of interleukin 16 are associated with joint destruction in patients with rheumatoid arthritis.
The Journal of rheumatology 2004;31(1):35-9.
2003: Tchetverikov I; Verzijl N; Huizinga T W; TeKoppele J M; Hanemaaijer R; DeGroot J
Active MMPs captured by alpha 2 macroglobulin as a marker of disease activity in rheumatoid arthritis.
Clinical and experimental rheumatology 2003;21(6):711-8.
2003: Seelen M A; Trouw L A; van der Hoorn J W A; Fallaux-van den Houten F C; Huizinga T W J; Daha M R; Roos A
Autoantibodies against mannose-binding lectin in systemic lupus erythematosus.
Clinical and experimental immunology 2003;134(2):335-43.
2003: Tchetverikov I; Lard L R; DeGroot J; Verzijl N; TeKoppele J M; Breedveld F C; Huizinga T W J; Hanemaaijer R
Matrix metalloproteinases-3, -8, -9 as markers of disease activity and joint damage progression in early rheumatoid arthritis.
Annals of the rheumatic diseases 2003;62(11):1094-9.
2003: Jeurissen S E R; Liauw L; Willems L N A; Huizinga T W J
Case Number 27: Jaw claudication in Takayasu's disease.
Annals of the rheumatic diseases 2003;62(10):922.
2003: Huizinga Tom W J
Genetics in rheumatoid arthritis.
Best practice & research. Clinical rheumatology 2003;17(5):703-16.
2003: van der Slot Annemarie J; Zuurmond Anne-Marie; Bardoel Alfons F J; Wijmenga Cisca; Pruijs Hans E H; Sillence David O; Brinckmann Jürgen; Abraham David J; Black Carol M; Verzijl Nicole; DeGroot Jeroen; Hanemaaijer Roeland; TeKoppele Johan M; Huizinga Tom W J; Bank Ruud A
Identification of PLOD2 as telopeptide lysyl hydroxylase, an important enzyme in fibrosis.
The Journal of biological chemistry 2003;278(42):40967-72.
2003: van Aken J; van Bilsen J H; Allaart C F; Huizinga T W; Breedveld F C
The Leiden Early Arthritis Clinic.
Clinical and experimental rheumatology 2003;21(5 Suppl 31):S100-5.
2003: Grootscholten C; Ligtenberg G; Derksen R H W M; Schreurs K M G; de Glas-Vos J W; Hagen E C; van den Wall Bake A W L; Huizinga T W J; van den Hoogen F H J; Bijl M; van Houwelingen J C; Snoek F J; Berden J H M
Health-related quality of life in patients with systemic lupus erythematosus: development and validation of a lupus specific symptom checklist.
Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation 2003;12(6):635-44.
2003: Huizinga Tom W J; Ioan-Facsinay Andreea
Soluble FcgammaRIIIa as a marker for rheumatoid arthritis: the use of genetics in selected populations to study pathogenetic pathways.
The Journal of rheumatology 2003;30(9):1904-6.
2003: Bayley Jean-Pierre; van Rietschoten Johanna G I; Bakker Aleida M; van Baarsen Lisa; Kaijzel Eric L; Wierenga Eddy A; van der Pouw Kraan Tineke C T M; Huizinga Tom W J; Verweij Cornelis L
Allele-specific expression of the IL-1 alpha gene in human CD4+ T cell clones.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(5):2349-53.
2003: Boers M; Nurmohamed M T; Doelman C J A; Lard L R; Verhoeven A C; Voskuyl A E; Huizinga T W J; van de Stadt R J; Dijkmans B A C; van der Linden Sj
Influence of glucocorticoids and disease activity on total and high density lipoprotein cholesterol in patients with rheumatoid arthritis.
Annals of the rheumatic diseases 2003;62(9):842-5.
2003: van der Pouw Kraan Tineke C T M; van Gaalen Floris A; Kasperkovitz Pia V; Verbeet Nicolette L; Smeets Tom J M; Kraan Maarten C; Fero Mike; Tak Paul-Peter; Huizinga Tom W J; Pieterman Elsbet; Breedveld Ferdinand C; Alizadeh Ash A; Verweij Cornelis L
Rheumatoid arthritis is a heterogeneous disease: evidence for differences in the activation of the STAT-1 pathway between rheumatoid tissues.
Arthritis and rheumatism 2003;48(8):2132-45.
2003: Bayley J-P; Baggen J M; van der Pouw-Kraan T; Crusius J B A; Huizinga T W J; Verweij C L
Association between polymorphisms in the human chemokine receptor genes CCR2 and CX3CR1 and rheumatoid arthritis.
Tissue antigens 2003;62(2):170-4.
2003: Bayley Jean-Pierre; Bakker Aleida M; Kaijzel Eric L; Wierenga Eddy A; van der Pouw-Kraan Tineke C T M; Huizinga Tom W J; Verweij Cornelis L
Analysis of allelic expression patterns of IL-2, IL-3, IL-4, and IL-13 in human CD4+ T cell clones.
European journal of immunology 2003;33(8):2142-8.
2003: Bayley J-P; Bakker A M; Kaijzel E L; Huizinga T W J; Verweij C L
Association of polymorphisms of the tumour necrosis factor receptors I and II and rheumatoid arthritis.
Rheumatology (Oxford, England) 2003;42(8):969-71.
2003: Wirtz Paul W; Huizinga Tom W J; Stoeken Dirk-Jan; Wintzen Axel R; Verschuuren Jan J
High innate production of interleukin-10 and tumor necrosis factor-alpha contributes to susceptibility for non-paraneoplastic Lambert-Eaton myasthenic syndrome.
Journal of neuroimmunology 2003;140(1-2):194-7.
2003: Lard L R; van Gaalen F A; Schonkeren J J M; Pieterman E J; Stoeken G; Vos K; Nelissen R G H H; Westendorp R G J; Hoeben R C; Breedveld F C; Toes R E M; Huizinga T W J
Association of the -2849 interleukin-10 promoter polymorphism with autoantibody production and joint destruction in rheumatoid arthritis.
Arthritis and rheumatism 2003;48(7):1841-8.
2003: van der Pol W-Ludo; Jansen Marc D; Sluiter Wim J; van de Sluis Bart; Leppers-van de Straat Fredriek G J; Kobayashi Tetsuo; Westendorp Rudi G J; Huizinga Tom W J; van de Winkel Jan G J
Evidence for non-random distribution of Fcgamma receptor genotype combinations.
Immunogenetics 2003;55(4):240-6.
2003: Steens S C A; Bosma G P Th; ten Cate R; Doornbos J; Kros J M; Laan L A E M; Steup-Beekman G M; van Buchem M A; Huizinga T W J
A neuroimaging follow up study of a patient with juvenile central nervous system systemic lupus erythematosus.
Annals of the rheumatic diseases 2003;62(6):583-6.
2003: van der Laan W H; Ronday H K; TeKoppele J M; Breedveld F C; Huizinga T W; Verheijen J H
No therapeutic effect of plasmin antagonist tranexamic acid in rheumatoid arthritis. A double-blind placebo-controlled pilot study.
Clinical and experimental rheumatology 2003;21(3):359-62.
2003: Bosma Gerlof P Th; Huizinga Tom W J; Mooijaart Simon P; Van Buchem Mark A
Abnormal brain diffusivity in patients with neuropsychiatric systemic lupus erythematosus.
AJNR. American journal of neuroradiology 2003;24(5):850-4.
2003: Hoekstra M; van Ede A E; Haagsma C J; van de Laar M A F J; Huizinga T W J; Kruijsen M W M; Laan R F J M
Factors associated with toxicity, final dose, and efficacy of methotrexate in patients with rheumatoid arthritis.
Annals of the rheumatic diseases 2003;62(5):423-6.
2003: van der Pouw Kraan T C T M; van Gaalen F A; Huizinga T W J; Pieterman E; Breedveld F C; Verweij C L
Discovery of distinctive gene expression profiles in rheumatoid synovium using cDNA microarray technology: evidence for the existence of multiple pathways of tissue destruction and repair.
Genes and immunity 2003;4(3):187-96.
2003: Moraes Milton O; Santos Adalberto R; Schonkeren Joris J M; Vanderborght Patrícia R; Ottenhoff Tom H M; Moraes Maria E; Moraes José R; Sampaio Elizabeth P; Sarno Euzenir N; Huizinga Tom W J
Interleukin-10 promoter haplotypes are differently distributed in the Brazilian versus the Dutch population.
Immunogenetics 2003;54(12):896-9.
2003: Tolboom Tanja C A; Medema Jan Paul; van Gaalen Floris A; Pieterman Elsbet; Huizinga Tom W J; Toes René E M
Fibroblast-like synoviocytes from rheumatoid arthritis patients express less FLICE-inhibitory protein than fibroblast-like synoviocytes from trauma patients: comment on the article by Schedel et al.
Arthritis and rheumatism 2003;48(3):858-9; author reply 859.
2003: Riyazi N; Spee J; Huizinga T W J; Schreuder G M T; de Vries R R P; Dekker F W; Kloppenburg M
HLA class II is associated with distal interphalangeal osteoarthritis.
Annals of the rheumatic diseases 2003;62(3):227-30.
2003: van der Laan W H; Quax P H A; Seemayer C A; Huisman L G M; Pieterman E J; Grimbergen J M; Verheijen J H; Breedveld F C; Gay R E; Gay S; Huizinga T W J; Pap T
Cartilage degradation and invasion by rheumatoid synovial fibroblasts is inhibited by gene transfer of TIMP-1 and TIMP-3.
Gene therapy 2003;10(3):234-42.
2002: Santos Adalberto R; Suffys Philip N; Vanderborght Patrícia R; Moraes Milton O; Vieira Leila M M; Cabello Pedro H; Bakker Aleida M; Matos Haroldo J; Huizinga Tom W J; Ottenhoff Tom H M; Sampaio Elizabeth P; Sarno Euzenir N
Role of tumor necrosis factor-alpha and interleukin-10 promoter gene polymorphisms in leprosy.
The Journal of infectious diseases 2002;186(11):1687-91.
2002: Huizinga Tom W J; Linn-Rasker Suzanne; Lard Leroy R; Westendorp Rudi G J
Genetic drift as an explanation for the reduced incidence of rheumatoid arthritis.
Arthritis and rheumatism 2002;46(11):3107.
2002: Tolboom T C A; Pieterman E; van der Laan W H; Toes R E M; Huidekoper A L; Nelissen R G H H; Breedveld F C; Huizinga T W J
Invasive properties of fibroblast-like synoviocytes: correlation with growth characteristics and expression of MMP-1, MMP-3, and MMP-10.
Annals of the rheumatic diseases 2002;61(11):975-80.
2002: de Craen Anton J M; Huizinga Tom W J; Westendorp Rudi G J
Multiple sclerosis and type 1 diabetes in Sardinia.
Lancet 2002;360(9341):1253.
2002: Bosma G P Th; Middelkoop H A M; Rood M J; Bollen E L E M; Huizinga T W J; van Buchem M A
Association of global brain damage and clinical functioning in neuropsychiatric systemic lupus erythematosus.
Arthritis and rheumatism 2002;46(10):2665-72.
2002: de Jong B A; Huizinga T W J; Zanelli E; Giphart M J; Bollen E L E M; Uitdehaag B M J; Polman C H; Westendorp R G J
Evidence for additional genetic risk indicators of relapse-onset MS within the HLA region.
Neurology 2002;59(4):549-55.
2002: Huizinga Tom W J
Genetics in rheumatoid arthritis.
Current rheumatology reports 2002;4(3):195-200.
2002: Huizinga Tom W J; Machold Klaus P; Breedveld Ferdinand C; Lipsky Peter E; Smolen Josef S
Criteria for early rheumatoid arthritis: from Bayes' law revisited to new thoughts on pathogenesis.
Arthritis and rheumatism 2002;46(5):1155-9.
2002: Goossens P H; Huizinga T W J
Adenoviral-mediated gene transfer to the synovial tissue.
Clinical and experimental rheumatology 2002;20(3):415-9.
2002: de Jong Brigit A; Huizinga Tom W J; Bollen Eduard L E M; Uitdehaag Bernard M J; Bosma Gerlof P Th; van Buchem Mark A; Remarque Edmond J; Burgmans Alexandra C S; Kalkers Nynke F; Polman Chris H; Westendorp Rudi G J
Production of IL-1beta and IL-1Ra as risk factors for susceptibility and progression of relapse-onset multiple sclerosis.
Journal of neuroimmunology 2002;126(1-2):172-9.
2002: de Jong Brigit A; Westendorp Rudi G J; Eskdale Joyce; Uitdehaag Bernard M J; Huizinga Tom W J
Frequency of functional interleukin-10 promoter polymorphism is different between relapse-onset and primary progressive multiple sclerosis.
Human immunology 2002;63(4):281-5.
2002: Dijstelbloem Hilde M; Hepkema Bouke G; Kallenberg Cees G M; van der Linden Michiel W; Keijsers Vivian; Huizinga Tom W J; Jansen Marc D; van de Winkel Jan G J
The R-H polymorphism of FCgamma receptor IIa as a risk factor for systemic lupus erythematosus is independent of single-nucleotide polymorphisms in the interleukin-10 gene promoter.
Arthritis and rheumatism 2002;46(4):1125-6.
2002: Lard L R; Boers M; Verhoeven A; Vos K; Visser H; Hazes J M W; Zwinderman A H; Schreuder G M T; Breedveld F C; De Vries R R P; van der Linden S; Zanelli E; Huizinga T W J
Early and aggressive treatment of rheumatoid arthritis patients affects the association of HLA class II antigens with progression of joint damage.
Arthritis and rheumatism 2002;46(4):899-905.
2002: Dehmeshki Jamshid; Van Buchem Mark A; Bosma Gerlof P T; Huizinga Tom W J; Tofts Paul S
Systemic lupus erythematosus: diagnostic application of magnetization transfer ratio histograms in patients with neuropsychiatric symptoms--initial results.
Radiology 2002;222(3):722-8.
2002: Kaijzel E L; van Dongen H; Bakker A M; Breedveld F C; Huizinga T W J; Verweij C L
Relationship of polymorphisms of the Interleukin-1 gene cluster to occurrence and severity of rheumatoid arthritis.
Tissue antigens 2002;59(2):122-6.
2002: de Jong B A; Westendorp R G J; Bakker A M; Huizinga T W J
Polymorphisms in or near tumour necrosis factor (TNF)-gene do not determine levels of endotoxin-induced TNF production.
Genes and immunity 2002;3(1):25-9.
2002: Küçükaycan Mehmet; Van Krugten Michiel; Pennings Herman-Jan; Huizinga Tom W J; Buurman Wim A; Dentener Mieke A; Wouters Emiel F M
Tumor necrosis factor-alpha +489G/A gene polymorphism is associated with chronic obstructive pulmonary disease.
Respiratory research 2002;3():29.
2002: Lard L R; Roep B O; Verburgh C A; Zwinderman A H; Huizinga T W J
Elevated IL-16 levels in patients with systemic lupus erythematosus are associated with disease severity but not with genetic susceptibility to lupus.
Lupus 2002;11(3):181-5.
2001: van der Pol W L; Huizinga T W; Vidarsson G; van der Linden M W; Jansen M D; Keijsers V; de Straat F G; Westerdaal N A; de Winkel J G; Westendorp R G
Relevance of Fcgamma receptor and interleukin-10 polymorphisms for meningococcal disease.
The Journal of infectious diseases 2001;184(12):1548-55.
2001: van Ede A E; Laan R F; Blom H J; Huizinga T W; Haagsma C J; Giesendorf B A; de Boo T M; van de Putte L B
The C677T mutation in the methylenetetrahydrofolate reductase gene: a genetic risk factor for methotrexate-related elevation of liver enzymes in rheumatoid arthritis patients.
Arthritis and rheumatism 2001;44(11):2525-30.
2001: van der Linden M W; van der Slik A R; Zanelli E; Giphart M J; Pieterman E; Schreuder G M; Westendorp R G; Huizinga T W
Six microsatellite markers on the short arm of chromosome 6 in relation to HLA-DR3 and TNF-308A in systemic lupus erythematosus.
Genes and immunity 2001;2(7):373-80.
2001: Lard L R; Huizinga T W; Hazes J M; Vliet Vlieland T P
Delayed referral of female patients with rheumatoid arthritis.
The Journal of rheumatology 2001;28(10):2190-2.
2001: Huizinga T W; Steens S C; van Buchem M A
Imaging modalities in central nervous system systemic lupus erythematosus.
Current opinion in rheumatology 2001;13(5):383-8.
2001: van Ede A E; Laan R F; Rood M J; Huizinga T W; van de Laar M A; van Denderen C J; Westgeest T A; Romme T C; de Rooij D J; Jacobs M J; de Boo T M; van der Wilt G J; Severens J L; Hartman M; Krabbe P F; Dijkmans B A; Breedveld F C; van de Putte L B
Effect of folic or folinic acid supplementation on the toxicity and efficacy of methotrexate in rheumatoid arthritis: a forty-eight week, multicenter, randomized, double-blind, placebo-controlled study.
Arthritis and rheumatism 2001;44(7):1515-24.
2001: Bayley J P; de Rooij H; van den Elsen P J; Huizinga T W; Verweij C L
Functional analysis of linker-scan mutants spanning the -376, -308, -244, and -238 polymorphic sites of the TNF-alpha promoter.
Cytokine 2001;14(6):316-23.
2001: Kaijzel E L; Bayley J P; van Krugten M V; Smith L; van de Linde P; Bakker A M; Breedveld F C; Huizinga T W; Verweij C L
Allele-specific quantification of tumor necrosis factor alpha (TNF) transcription and the role of promoter polymorphisms in rheumatoid arthritis patients and healthy individuals.
Genes and immunity 2001;2(3):135-44.
2001: Goossens P H; Havenga M J; Pieterman E; Lemckert A A; Breedveld F C; Bout A; Huizinga T W
Infection efficiency of type 5 adenoviral vectors in synovial tissue can be enhanced with a type 16 fiber.
Arthritis and rheumatism 2001;44(3):570-7.
2001: Bruijn J A; Verburgh C A; Huizinga T W
Classifying lupus nephritis: a 32-year-old woman with systemic lupus erythematosus and nephritic syndrome.
American journal of kidney diseases : the official journal of the National Kidney Foundation 2001;37(3):653-7.
2001: Rood M J; Haverman J F; van Duinen S G; Breedveld F C; Verschuuren J J; Huizinga T W
CNS involvement in systemic lupus erythematosus: a case with remarkable histopathological findings.
Annals of the rheumatic diseases 2001;60(3):299-300.
2001: van der Linden M W; van Lopik T; Aarden L A; Westendorp R G; Huizinga T W
Soluble CD95 concentrations are increased in patients with severe systemic lupus erythematosus, but not in their first degree relatives.
Annals of the rheumatic diseases 2001;60(3):237-41.
2001: van der Linden M W; Westendorp R G; Zidane M; Meheus L; Huizinga T W
Autoantibodies within families of patients with systemic lupus erythematosus are not directed against the same nuclear antigens.
The Journal of rheumatology 2001;28(2):284-7.
2001: Polderman M C; Huizinga T W; Le Cessie S; Pavel S
UVA-1 cold light treatment of SLE: a double blind, placebo controlled crossover trial.
Annals of the rheumatic diseases 2001;60(2):112-5.
2001: Goossens P H; Vogels R; Pieterman E; Havenga M J; Bout A; Breedveld F C; Valerio D; Huizinga T W
The influence of synovial fluid on adenovirus-mediated gene transfer to the synovial tissue.
Arthritis and rheumatism 2001;44(1):48-52.
2000: Huizinga T W; Keijsers V; Yanni G; Hall M; Ramage W; Lanchbury J; Pitzalis C; Drossaers-Bakker W K; Westendorp R G; Breedveld F C; Panayi G; Verweij C L
Are differences in interleukin 10 production associated with joint damage?
Rheumatology (Oxford, England) 2000;39(11):1180-8.
2000: Bosma G P; Rood M J; Huizinga T W; de Jong B A; Bollen E L; van Buchem M A
Detection of cerebral involvement in patients with active neuropsychiatric systemic lupus erythematosus by the use of volumetric magnetization transfer imaging.
Arthritis and rheumatism 2000;43(11):2428-36.
2000: de Jong B A; Schrijver H M; Huizinga T W; Bollen E L; Polman C H; Uitdehaag B M; Kersbergen M C; Sturk A; Westendorp R G
Innate production of interleukin-10 and tumor necrosis factor affects the risk of multiple sclerosis.
Annals of neurology 2000;48(4):641-6.
2000: Goossens P H; Schouten G J; Heemskerk B; 't Hart B A; Bout A; Kluin P M; Breedveld F C; Valerio D; Huizinga T W
The effect of promoter strength in adenoviral vectors in hyperplastic synovium.
Clinical and experimental rheumatology 2000;18(5):547-52.
2000: van der Linden M W; Westendorp R G; Sturk A; Bergman W; Huizinga T W
High interleukin-10 production in first-degree relatives of patients with generalized but not cutaneous lupus erythematosus.
Journal of investigative medicine : the official publication of the American Federation for Clinical Research 2000;48(5):327-34.
2000: Rood M J; Borggreve S E; Huizinga T W
Sensitivity to change of the MOS SF-36 quality of life assessment questionnaire in patients with systemic lupus erythematosus taking immunosuppressive therapy.
The Journal of rheumatology 2000;27(8):2057-9.
2000: Goossens P H; Heemskerk B; van Tongeren J; Zwinderman A H; Vliet Vlieland T P; Huizinga T W
Reliability and sensitivity to change of various measures of hand function in relation to treatment of synovitis of the metacarpophalangeal joint in rheumatoid arthritis.
Rheumatology (Oxford, England) 2000;39(8):909-13.
2000: van der Laan W H; Pap T; Ronday H K; Grimbergen J M; Huisman L G; TeKoppele J M; Breedveld F C; Gay R E; Gay S; Huizinga T W; Verheijen J H; Quax P H
Cartilage degradation and invasion by rheumatoid synovial fibroblasts is inhibited by gene transfer of a cell surface-targeted plasmin inhibitor.
Arthritis and rheumatism 2000;43(8):1710-8.
2000: Rood M J; van Krugten M V; Zanelli E; van der Linden M W; Keijsers V; Schreuder G M; Verduyn W; Westendorp R G; de Vries R R; Breedveld F C; Verweij C L; Huizinga T W
TNF-308A and HLA-DR3 alleles contribute independently to susceptibility to systemic lupus erythematosus.
Arthritis and rheumatism 2000;43(1):129-34.
2000: Bosma G P; Rood M J; Zwinderman A H; Huizinga T W; van Buchem M A
Evidence of central nervous system damage in patients with neuropsychiatric systemic lupus erythematosus, demonstrated by magnetization transfer imaging.
Arthritis and rheumatism 2000;43(1):48-54.
1999: van Krugten M V; Huizinga T W; Kaijzel E L; Zanelli E; Drossaers-Bakker K W; van de Linde P; Hazes J M; Zwinderman A H; Breedveld F C; Verweij C L
Association of the TNF +489 polymorphism with susceptibility and radiographic damage in rheumatoid arthritis.
Genes and immunity 1999;1(2):91-6.
1999: Eskdale J; Keijsers V; Huizinga T; Gallagher G
Microsatellite alleles and single nucleotide polymorphisms (SNP) combine to form four major haplotype families at the human interleukin-10 (IL-10) locus.
Genes and immunity 1999;1(2):151-5.
1999: Huizinga T W; van der Linden M W; Deneys-Laporte V; Breedveld F C
Interleukin-10 as an explanation for pregnancy-induced flare in systemic lupus erythematosus and remission in rheumatoid arthritis.
Rheumatology (Oxford, England) 1999;38(6):496-8.
1999: Goossens P H; Schouten G J; 't Hart B A; Bout A; Brok H P; Kluin P M; Breedveld F C; Valerio D; Huizinga T W
Feasibility of adenovirus-mediated nonsurgical synovectomy in collagen-induced arthritis-affected rhesus monkeys.
Human gene therapy 1999;10(7):1139-49.
1999: Rood M J; Keijsers V; van der Linden M W; Tong T Q; Borggreve S E; Verweij C L; Breedveld F C; Huizinga T W
Neuropsychiatric systemic lupus erythematosus is associated with imbalance in interleukin 10 promoter haplotypes.
Annals of the rheumatic diseases 1999;58(2):85-9.
1999: Kaijzel E L; Brinkman B M; van Krugten M V; Smith L; Huizinga T W; Verjans G M; Breedveld F C; Verweij C L
Polymorphism within the tumor necrosis factor alpha (TNF) promoter region in patients with ankylosing spondylitis.
Human immunology 1999;60(2):140-4.
1999: van der Horst-Bruinsma I E; Huizinga T W; Lagaay E M; Hazes J M; Breedveld F C; Schreuder G M; Tomson T A; Zwinderman A H; van Rood J J; de Vries R R
The influence of a partially HLA-matched blood transfusion on the disease activity of rheumatoid arthritis.
Rheumatology (Oxford, England) 1999;38(1):53-8.
1999: Rood M J; Breedveld F C; Huizinga T W
The accuracy of diagnosing neuropsychiatric systemic lupus erythematosus in a series of 49 hospitalized patients.
Clinical and experimental rheumatology 1999;17(1):55-61.
1999: Rood M J; ten Cate R; van Suijlekom-Smit L W; den Ouden E J; Ouwerkerk F E; Breedveld F C; Huizinga T W
Childhood-onset Systemic Lupus Erythematosus: clinical presentation and prognosis in 31 patients.
Scandinavian journal of rheumatology 1999;28(4):222-6.
1998: Kaijzel E L; van Krugten M V; Brinkman B M; Huizinga T W; van der Straaten T; Hazes J M; Ziegler-Heitbrock H W; Nedospasov S A; Breedveld F C; Verweij C L
Functional analysis of a human tumor necrosis factor alpha (TNF-alpha) promoter polymorphism related to joint damage in rheumatoid arthritis.
Molecular medicine (Cambridge, Mass.) 1998;4(11):724-33.
1998: Zanelli E; Huizinga T W; Guerne P A; Vischer T L; Tiercy J M; Verduyn W; Schreuder G M; Breedveld F C; de Vries R R
An extended HLA-DQ-DR haplotype rather than DRB1 alone contributes to RA predisposition.
Immunogenetics 1998;48(6):394-401.
1998: van der Linden M W; Huizinga T W; Stoeken D J; Sturk A; Westendorp R G
Determination of tumour necrosis factor-alpha and interleukin-10 production in a whole blood stimulation system: assessment of laboratory error and individual variation.
Journal of immunological methods 1998;218(1-2):63-71.
1998: Rood M J; Van Der Velde E A; Ten Cate R; Breedveld F C; Huizinga T W
Female sex hormones at the onset of systemic lupus erythematosus affect survival.
British journal of rheumatology 1998;37(9):1008-10.
1998: Eskdale J; Gallagher G; Verweij C L; Keijsers V; Westendorp R G; Huizinga T W
Interleukin 10 secretion in relation to human IL-10 locus haplotypes.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(16):9465-70.
1997: Westendorp R G; Langermans J A; Huizinga T W; Verweij C L; Sturk A
Genetic influence on cytokine production in meningococcal disease.
Lancet 1997;349(9069):1912-3.
1997: Brinkman B M; Huizinga T W; Kurban S S; van der Velde E A; Schreuder G M; Hazes J M; Breedveld F C; Verweij C L
Tumour necrosis factor alpha gene polymorphisms in rheumatoid arthritis: association with susceptibility to, or severity of, disease?
British journal of rheumatology 1997;36(5):516-21.
1997: Huizinga T W; Westendorp R G; Bollen E L; Keijsers V; Brinkman B M; Langermans J A; Breedveld F C; Verweij C L; van de Gaer L; Dams L; Crusius J B; García-Gonzalez A; van Oosten B W; Polman C H; Peña A S
TNF-alpha promoter polymorphisms, production and susceptibility to multiple sclerosis in different groups of patients.
Journal of neuroimmunology 1997;72(2):149-53.
1997: Westendorp R G; Langermans J A; Huizinga T W; Elouali A H; Verweij C L; Boomsma D I; Vandenbroucke J P;
Genetic influence on cytokine production and fatal meningococcal disease.
Lancet 1997;349(9046):170-3.
1996: Huizinga T W; Dijkmans B A; van der Velde E A; van de Pouw Kraan T C; Verweij C L; Breedveld F C
An open study of pentoxyfylline and thalidomide as adjuvant therapy in the treatment of rheumatoid arthritis.
Annals of the rheumatic diseases 1996;55(11):833-6.
1996: Brinkman B M; Huizinga T W; Breedveld F C; Verweij C L
Allele-specific quantification of TNFA transcripts in rheumatoid arthritis.
Human genetics 1996;97(6):813-8.
1995: Brinkman B M; Kaijzel E L; Huizinga T W; Giphart M J; Breedveld F C; Verweij C L
Detection of a C-insertion polymorphism within the human tumor necrosis factor alpha (TNFA) gene.
Human genetics 1995;96(4):493.
1994: Huizinga T W; de Haas M; van Oers M H; Kleijer M; Vilé H; van der Wouw P A; Moulijn A; van Weezel H; Roos D; von dem Borne A E
The plasma concentration of soluble Fc-gamma RIII is related to production of neutrophils.
British journal of haematology 1994;87(3):459-63.
1992: Carr R; Huizinga T W; Kleijer M; Davies J M
Changes in plasma FcRIII demonstrate increasing receptor production during late pregnancy and after preterm birth.
Pediatric research 1992;32(5):505-8.
1990: van der Schoot C E; Huizinga T W; van 't Veer-Korthof E T; Wijmans R; Pinkster J; von dem Borne A E
Deficiency of glycosyl-phosphatidylinositol-linked membrane glycoproteins of leukocytes in paroxysmal nocturnal hemoglobinuria, description of a new diagnostic cytofluorometric assay.
Blood 1990;76(9):1853-9.
1990: Huizinga T W; Kuijpers R W; Kleijer M; Schulpen T W; Cuypers H T; Roos D; von dem Borne A E
Maternal genomic neutrophil FcRIII deficiency leading to neonatal isoimmune neutropenia.
Blood 1990;76(10):1927-32.
1990: Huizinga T W; de Haas M; Kleijer M; Nuijens J H; Roos D; von dem Borne A E
Soluble Fc gamma receptor III in human plasma originates from release by neutrophils.
The Journal of clinical investigation 1990;86(2):416-23.
1990: Huizinga T W; Roos D; von dem Borne A E
Neutrophil Fc-gamma receptors: a two-way bridge in the immune system.
Blood 1990;75(6):1211-4.
1990: Huizinga T W; Dolman K M; van der Linden N J; Kleijer M; Nuijens J H; von dem Borne A E; Roos D
Phosphatidylinositol-linked FcRIII mediates exocytosis of neutrophil granule proteins, but does not mediate initiation of the respiratory burst.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(4):1432-7.
1990: Klaassen R J; Ouwehand W H; Huizinga T W; Engelfriet C P; von dem Borne A E
The Fc-receptor III of cultured human monocytes. Structural similarity with FcRIII of natural killer cells and role in the extracellular lysis of sensitized erythrocytes.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(2):599-606.
1990: Huizinga T W; Kleijer M; Tetteroo P A; Roos D; von dem Borne A E
Biallelic neutrophil Na-antigen system is associated with a polymorphism on the phospho-inositol-linked Fc gamma receptor III (CD16).
Blood 1990;75(1):213-7.
1990: Jost C R; Huizinga T W; de Goede R; Fransen J A; Tetteroo P A; Daha M R; Ginsel L A
Intracellular localization and de novo synthesis of FcRIII in human neutrophil granulocytes.
Blood 1990;75(1):144-51.
1989: Huizinga T W; Kerst M; Nuyens J H; Vlug A; von dem Borne A E; Roos D; Tetteroo P A
Binding characteristics of dimeric IgG subclass complexes to human neutrophils.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(7):2359-64.
1989: Huizinga T W; van Kemenade F; Koenderman L; Dolman K M; von dem Borne A E; Tetteroo P A; Roos D
The 40-kDa Fc gamma receptor (FcRII) on human neutrophils is essential for the IgG-induced respiratory burst and IgG-induced phagocytosis.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(7):2365-9.
1988: Huizinga T W; van der Schoot C E; Jost C; Klaassen R; Kleijer M; von dem Borne A E; Roos D; Tetteroo P A
The PI-linked receptor FcRIII is released on stimulation of neutrophils.
Nature 1988;333(6174):667-9.

Sign-in to see more

Sign-in free and Explore the Exciting World of BiomedExperts:

NetworkView

Tom Huizinga

Research Profile (preview)

Disorders

Chemicals & Drugs

Physiology

Genes & Molecular Sequences

Anatomy

Concepts & Ideas

Network (preview)

Publications

Sign in free and see...

Visualized networks:

GeoTargeted Searches:

Research Profiles:

Geonetwork of Tom Huizinga (preview)

All Publications