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Scott Hultgren

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Anatomy

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Physiology

Bacterial Adhesion

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Amino Acid Sequence

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Co-Publications
Name
48
Pinkner, Jerome
14
Waksman, Gabriel
13
Dodson, Karen
12
Almqvist, Fredrik
12
Schilling, Joel
11
Normark, Staffan
10
Mulvey, Matthew
10
Kihlberg, Jan
10
Jones, CH
9
Striker, Rob T.
8
Knight, Stefan
8
Hunstad, David
7
Heuser, John
7
Langermann, Solomon
7
Sauer, Frederic

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Publications

TOP 3
Cegelski Lynette; Pinkner Jerome S; Hammer Neal D; Cusumano Corinne K; Hung Chia S; Chorell Erik; Aberg Veronica; Walker Jennifer N; Seed Patrick C; Almqvist Fredrik; Chapman Matthew R; Hultgren Scott J
Small-molecule inhibitors target Escherichia coli amyloid biogenesis and biofilm formation.
Cusumano Corinne K; Hultgren Scott J
Bacterial adhesion - A source of alternate antibiotic targets.
Waksman Gabriel; Hultgren Scott J
Structural biology of the chaperone-usher pathway of pilus biogenesis.

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All Publications

2009: Cegelski Lynette; Pinkner Jerome S; Hammer Neal D; Cusumano Corinne K; Hung Chia S; Chorell Erik; Aberg Veronica; Walker Jennifer N; Seed Patrick C; Almqvist Fredrik; Chapman Matthew R; Hultgren Scott J
Small-molecule inhibitors target Escherichia coli amyloid biogenesis and biofilm formation.
Nature chemical biology 2009;5(12):913-9.
2009: Cusumano Corinne K; Hultgren Scott J
Bacterial adhesion - A source of alternate antibiotic targets.
IDrugs : the investigational drugs journal 2009;12(11):699-705.
2009: Waksman Gabriel; Hultgren Scott J
Structural biology of the chaperone-usher pathway of pilus biogenesis.
Nature reviews. Microbiology 2009;7(11):765-74.
2009: Kostakioti Maria; Hadjifrangiskou Maria; Pinkner Jerome S; Hultgren Scott J
QseC-mediated dephosphorylation of QseB is required for expression of genes associated with virulence in uropathogenic Escherichia coli.
Molecular microbiology 2009;73(6):1020-31.
2009: Guiton Pascale S; Hung Chia S; Kline Kimberly A; Roth Robyn; Kau Andrew L; Hayes Ericka; Heuser John; Dodson Karen W; Caparon Michael G; Hultgren Scott J
Contribution of autolysin and Sortase a during Enterococcus faecalis DNA-dependent biofilm development.
Infection and immunity 2009;77(9):3626-38.
2009: Mysorekar Indira U; Isaacson-Schmid Megan; Walker Jennifer N; Mills Jason C; Hultgren Scott J
Bone morphogenetic protein 4 signaling regulates epithelial renewal in the urinary tract in response to uropathogenic infection.
Cell host & microbe 2009;5(5):463-75.
2009: Kline Kimberly A; Kau Andrew L; Chen Swaine L; Lim Adeline; Pinkner Jerome S; Rosch Jason; Nallapareddy Sreedhar R; Murray Barbara E; Henriques-Normark Birgitta; Beatty Wandy; Caparon Michael G; Hultgren Scott J
Mechanism for sortase localization and the role of sortase localization in efficient pilus assembly in Enterococcus faecalis.
Journal of bacteriology 2009;191(10):3237-47.
2009: Hung Chia-Suei; Dodson Karen W; Hultgren Scott J
A murine model of urinary tract infection.
Nature protocols 2009;4(8):1230-43.
2008: Ingersoll Molly A; Kline Kimberly A; Nielsen Hailyn V; Hultgren Scott J
G-CSF induction early in uropathogenic Escherichia coli infection of the urinary tract modulates host immunity.
Cellular microbiology 2008;10(12):2568-78.
2008: Verger Denis; Rose Rebecca J; Paci Emanuele; Costakes Greg; Daviter Tina; Hultgren Scott; Remaut Han; Ashcroft Alison E; Radford Sheena E; Waksman Gabriel
Structural determinants of polymerization reactivity of the P pilus adaptor subunit PapF.
Structure (London, England : 1993) 2008;16(11):1724-31.
2008: Rosen David A; Hung Chia-Suei; Kline Kimberly A; Hultgren Scott J
Streptozocin-induced diabetic mouse model of urinary tract infection.
Infection and immunity 2008;76(9):4290-8.
2008: Rosen David A; Pinkner Jerome S; Walker Jennifer N; Elam Jennifer Stine; Jones Jennifer M; Hultgren Scott J
Molecular variations in Klebsiella pneumoniae and Escherichia coli FimH affect function and pathogenesis in the urinary tract.
Infection and immunity 2008;76(7):3346-56.
2008: Rosen David A; Pinkner Jerome S; Jones Jennifer M; Walker Jennifer N; Clegg Steven; Hultgren Scott J
Utilization of an intracellular bacterial community pathway in Klebsiella pneumoniae urinary tract infection and the effects of FimK on type 1 pilus expression.
Infection and immunity 2008;76(7):3337-45.
2008: Berg Veronica; Das Pralay; Chorell Erik; Hedenström Mattias; Pinkner Jerome S; Hultgren Scott J; Almqvist Fredrik
Carboxylic acid isosteres improve the activity of ring-fused 2-pyridones that inhibit pilus biogenesis in E. coli.
Bioorganic & medicinal chemistry letters 2008;18(12):3536-40.
2008: Remaut Han; Tang Chunyan; Henderson Nadine S; Pinkner Jerome S; Wang Tao; Hultgren Scott J; Thanassi David G; Waksman Gabriel; Li Huilin
Fiber formation across the bacterial outer membrane by the chaperone/usher pathway.
Cell 2008;133(4):640-52.
2008: Justice Sheryl S; Hunstad David A; Cegelski Lynette; Hultgren Scott J
Morphological plasticity as a bacterial survival strategy.
Nature reviews. Microbiology 2008;6(2):162-8.
2008: Cegelski Lynette; Marshall Garland R; Eldridge Gary R; Hultgren Scott J
The biology and future prospects of antivirulence therapies.
Nature reviews. Microbiology 2008;6(1):17-27.
2008: Hannan Thomas J; Mysorekar Indira U; Chen Swaine L; Walker Jennifer N; Jones Jennifer M; Pinkner Jerome S; Hultgren Scott J; Seed Patrick C
LeuX tRNA-dependent and -independent mechanisms of Escherichia coli pathogenesis in acute cystitis.
Molecular microbiology 2008;67(1):116-28.
2008: Wellens Adinda; Garofalo Corinne; Nguyen Hien; Van Gerven Nani; Slättegård Rikard; Hernalsteens Jean-Pierre; Wyns Lode; Oscarson Stefan; De Greve Henri; Hultgren Scott; Bouckaert Julie
Intervening with urinary tract infections using anti-adhesives based on the crystal structure of the FimH-oligomannose-3 complex.
PloS one 2008;3(4):e2040.
2007: Rosen David A; Hooton Thomas M; Stamm Walter E; Humphrey Peter A; Hultgren Scott J
Detection of intracellular bacterial communities in human urinary tract infection.
PLoS medicine 2007;4(12):e329.
2007: Wright Kelly J; Seed Patrick C; Hultgren Scott J
Development of intracellular bacterial communities of uropathogenic Escherichia coli depends on type 1 pili.
Cellular microbiology 2007;9(9):2230-41.
2007: Lee Yvonne M; Dodson Karen W; Hultgren Scott J
Adaptor function of PapF depends on donor strand exchange in P-pilus biogenesis of Escherichia coli.
Journal of bacteriology 2007;189(14):5276-83.
2007: Verger Denis; Bullitt Esther; Hultgren Scott J; Waksman Gabriel
Crystal structure of the P pilus rod subunit PapA.
PLoS pathogens 2007;3(5):e73.
2007: Aberg Veronica; Fällman Erik; Axner Ove; Uhlin Bernt Eric; Hultgren Scott J; Almqvist Fredrik
Pilicides regulate pili expression in E. coli without affecting the functional properties of the pilus rod.
Molecular bioSystems 2007;3(3):214-8.
2007: Garofalo Corinne K; Hooton Thomas M; Martin Steven M; Stamm Walter E; Palermo Joseph J; Gordon Jeffrey I; Hultgren Scott J
Escherichia coli from urine of female patients with urinary tract infections is competent for intracellular bacterial community formation.
Infection and immunity 2007;75(1):52-60.
2006: Justice Sheryl S; Hunstad David A; Seed Patrick C; Hultgren Scott J
Filamentation by Escherichia coli subverts innate defenses during urinary tract infection.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(52):19884-9.
2006: Verger Denis; Miller Eric; Remaut Han; Waksman Gabriel; Hultgren Scott
Molecular mechanism of P pilus termination in uropathogenic Escherichia coli.
EMBO reports 2006;7(12):1228-32.
2006: Pinkner Jerome S; Remaut Han; Buelens Floris; Miller Eric; Aberg Veronica; Pemberton Nils; Hedenström Mattias; Larsson Andreas; Seed Patrick; Waksman Gabriel; Hultgren Scott J; Almqvist Fredrik
Rationally designed small compounds inhibit pilus biogenesis in uropathogenic bacteria.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(47):17897-902.
2006: Miller Eric; Garcia Tzintzuni; Hultgren Scott; Oberhauser Andres F
The mechanical properties of E. coli type 1 pili measured by atomic force microscopy techniques.
Biophysical journal 2006;91(10):3848-56.
2006: Berg Veronica; Sellstedt Magnus; Hedenström Mattias; Pinkner Jerome S; Hultgren Scott J; Almqvist Fredrik
Design, synthesis and evaluation of peptidomimetics based on substituted bicyclic 2-pyridones-targeting virulence of uropathogenic E. coli.
Bioorganic & medicinal chemistry 2006;14(22):7563-81.
2006: Mysorekar Indira U; Hultgren Scott J
Mechanisms of uropathogenic Escherichia coli persistence and eradication from the urinary tract.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(38):14170-5.
2006: Justice Sheryl S; Lauer Scott R; Hultgren Scott J; Hunstad David A
Maturation of intracellular Escherichia coli communities requires SurA.
Infection and immunity 2006;74(8):4793-800.
2006: Remaut Han; Rose Rebecca J; Hannan Thomas J; Hultgren Scott J; Radford Sheena E; Ashcroft Alison E; Waksman Gabriel
Donor-strand exchange in chaperone-assisted pilus assembly proceeds through a concerted beta strand displacement mechanism.
Molecular cell 2006;22(6):831-42.
2006: Bann James G; Cegelski Lynette; Hultgren Scott J
LRP6 holds the key to the entry of anthrax toxin.
Cell 2006;124(6):1119-21.
2006: Robinson Lloyd S; Ashman Elisabeth M; Hultgren Scott J; Chapman Matthew R
Secretion of curli fibre subunits is mediated by the outer membrane-localized CsgG protein.
Molecular microbiology 2006;59(3):870-81.
2005: Meehl Michael A; Pinkner Jerome S; Anderson Patricia J; Hultgren Scott J; Caparon Michael G
A novel endogenous inhibitor of the secreted streptococcal NAD-glycohydrolase.
PLoS pathogens 2005;1(4):e35.
2005: Hedenström Mattias; Emtenäs Hans; Pemberton Nils; Aberg Veronica; Hultgren Scott J; Pinkner Jerome S; Tegman Viola; Almqvist Fredrik; Sethson Ingmar; Kihlberg Jan
NMR studies of interactions between periplasmic chaperones from uropathogenic E. coli and pilicides that interfere with chaperone function and pilus assembly.
Organic & biomolecular chemistry 2005;3(23):4193-200.
2005: Justice Sheryl S; Hunstad David A; Harper Jill Reiss; Duguay Amy R; Pinkner Jerome S; Bann James; Frieden Carl; Silhavy Thomas J; Hultgren Scott J
Periplasmic peptidyl prolyl cis-trans isomerases are not essential for viability, but SurA is required for pilus biogenesis in Escherichia coli.
Journal of bacteriology 2005;187(22):7680-6.
2005: Aberg Veronica; Hedenström Mattias; Pinkner Jerome S; Hultgren S J; Almqvist Fredrik
C-Terminal properties are important for ring-fused 2-pyridones that interfere with the chaperone function in uropathogenic E. coli.
Organic & biomolecular chemistry 2005;3(21):3886-92.
2005: Wright Kelly J; Seed Patrick C; Hultgren Scott J
Uropathogenic Escherichia coli flagella aid in efficient urinary tract colonization.
Infection and immunity 2005;73(11):7657-68.
2005: Hunstad David A; Justice Sheryl S; Hung Chia S; Lauer Scott R; Hultgren Scott J
Suppression of bladder epithelial cytokine responses by uropathogenic Escherichia coli.
Infection and immunity 2005;73(7):3999-4006.
2005: Seed Patrick C; Hultgren Scott J
Blueprinting the regulatory response of Escherichia coli to the urinary tract.
Trends in microbiology 2005;13(6):246-8.
2005: Kau Andrew L; Martin Steven M; Lyon William; Hayes Ericka; Caparon Michael G; Hultgren Scott J
Enterococcus faecalis tropism for the kidneys in the urinary tract of C57BL/6J mice.
Infection and immunity 2005;73(4):2461-8.
2005: Ohlsson Jörgen; Larsson Andreas; Haataja Sauli; Alajääski Jenny; Stenlund Peter; Pinkner Jerome S; Hultgren Scott J; Finne Jukka; Kihlberg Jan; Nilsson Ulf J
Structure-activity relationships of galabioside derivatives as inhibitors of E. coli and S. suis adhesins: nanomolar inhibitors of S. suis adhesins.
Organic & biomolecular chemistry 2005;3(5):886-900.
2005: Larsson Andreas; Johansson Susanne M C; Pinkner Jerome S; Hultgren Scott J; Almqvist Fredrik; Kihlberg Jan; Linusson Anna
Multivariate design, synthesis, and biological evaluation of peptide inhibitors of FimC/FimH protein-protein interactions in uropathogenic Escherichia coli.
Journal of medicinal chemistry 2005;48(4):935-45.
2005: Kau Andrew L; Hunstad David A; Hultgren Scott J
Interaction of uropathogenic Escherichia coli with host uroepithelium.
Current opinion in microbiology 2005;8(1):54-9.
2005: Bouckaert Julie; Berglund Jenny; Schembri Mark; De Genst Erwin; Cools Lieve; Wuhrer Manfred; Hung Chia-Suei; Pinkner Jerome; Slättegård Rikard; Zavialov Anton; Choudhury Devapriya; Langermann Solomon; Hultgren Scott J; Wyns Lode; Klemm Per; Oscarson Stefan; Knight Stefan D; De Greve Henri
Receptor binding studies disclose a novel class of high-affinity inhibitors of the Escherichia coli FimH adhesin.
Molecular microbiology 2005;55(2):441-55.
2004: Bann James G; Pinkner Jerome S; Frieden Carl; Hultgren Scott J
Catalysis of protein folding by chaperones in pathogenic bacteria.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(50):17389-93.
2004: Sauer Frederic G; Remaut Han; Hultgren Scott J; Waksman Gabriel
Fiber assembly by the chaperone-usher pathway.
Biochimica et biophysica acta 2004;1694(1-3):259-67.
2004: Anderson Gregory G; Martin Steven M; Hultgren Scott J
Host subversion by formation of intracellular bacterial communities in the urinary tract.
Microbes and infection / Institut Pasteur 2004;6(12):1094-101.
2004: Anderson Gregory G; Dodson Karen W; Hooton Thomas M; Hultgren Scott J
Intracellular bacterial communities of uropathogenic Escherichia coli in urinary tract pathogenesis.
Trends in microbiology 2004;12(9):424-30.
2004: Lee Yvonne M; DiGiuseppe Patricia A; Silhavy Thomas J; Hultgren Scott J
P pilus assembly motif necessary for activation of the CpxRA pathway by PapE in Escherichia coli.
Journal of bacteriology 2004;186(13):4326-37.
2004: Roberts James A; Kaack M Bernice; Baskin Gary; Chapman Matthew R; Hunstad David A; Pinkner Jerome S; Hultgren Scott J
Antibody responses and protection from pyelonephritis following vaccination with purified Escherichia coli PapDG protein.
The Journal of urology 2004;171(4):1682-5.
2004: Sexton Jessica A; Pinkner Jerome S; Roth Robyn; Heuser John E; Hultgren Scott J; Vogel Joseph P
The Legionella pneumophila PilT homologue DotB exhibits ATPase activity that is critical for intracellular growth.
Journal of bacteriology 2004;186(6):1658-66.
2004: Justice Sheryl S; Hung Chia; Theriot Julie A; Fletcher Daniel A; Anderson Gregory G; Footer Matthew J; Hultgren Scott J
Differentiation and developmental pathways of uropathogenic Escherichia coli in urinary tract pathogenesis.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(5):1333-8.
2003: Lee Yvonne M; Almqvist Fredrik; Hultgren Scott J
Targeting virulence for antimicrobial chemotherapy.
Current opinion in pharmacology 2003;3(5):513-9.
2003: Anderson Gregory G; Palermo Joseph J; Schilling Joel D; Roth Robyn; Heuser John; Hultgren Scott J
Intracellular bacterial biofilm-like pods in urinary tract infections.
Science (New York, N.Y.) 2003;301(5629):105-7.
2003: Larsson Andreas; Ohlsson Jörgen; Dodson Karen W; Hultgren Scott J; Nilsson Ulf; Kihlberg Jan
Quantitative studies of the binding of the class II PapG adhesin from uropathogenic Escherichia coli to oligosaccharides.
Bioorganic & medicinal chemistry 2003;11(10):2255-61.
2003: Barnhart Michelle M; Sauer Frederic G; Pinkner Jerome S; Hultgren Scott J
Chaperone-subunit-usher interactions required for donor strand exchange during bacterial pilus assembly.
Journal of bacteriology 2003;185(9):2723-30.
2003: Emtenäs Hans; Carlsson Marcus; Pinkner Jerome S; Hultgren Scott J; Almqvist Fredrik
Stereoselective synthesis of optically active bicyclic beta-lactam carboxylic acids that target pilus biogenesis in pathogenic bacteria.
Organic & biomolecular chemistry 2003;1(8):1308-14.
2003: Schilling Joel D; Martin Steven M; Hung Chia S; Lorenz Robin G; Hultgren Scott J
Toll-like receptor 4 on stromal and hematopoietic cells mediates innate resistance to uropathogenic Escherichia coli.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(7):4203-8.
2003: Schilling Joel D; Martin Steven M; Hunstad David A; Patel Kunal P; Mulvey Matthew A; Justice Sheryl S; Lorenz Robin G; Hultgren Scott J
CD14- and Toll-like receptor-dependent activation of bladder epithelial cells by lipopolysaccharide and type 1 piliated Escherichia coli.
Infection and immunity 2003;71(3):1470-80.
2002: Schilling Joel D; Lorenz Robin G; Hultgren Scott J
Effect of trimethoprim-sulfamethoxazole on recurrent bacteriuria and bacterial persistence in mice infected with uropathogenic Escherichia coli.
Infection and immunity 2002;70(12):7042-9.
2002: Sauer Frederic G; Pinkner Jerome S; Waksman Gabriel; Hultgren Scott J
Chaperone priming of pilus subunits facilitates a topological transition that drives fiber formation.
Cell 2002;111(4):543-51.
2002: Emtenäs Hans; Ahlin Kristoffer; Pinkner Jerome S; Hultgren Scott J; Almqvist Fredrik
Design and parallel solid-phase synthesis of ring-fused 2-pyridinones that target pilus biogenesis in pathogenic bacteria.
Journal of combinatorial chemistry 2002;4(6):630-9.
2002: Schilling Joel D; Hultgren Scott J; Lorenz Robin G
Recent advances in the molecular basis of pathogen recognition and host responses in the urinary tract.
International reviews of immunology 2002;21(4-5):291-304.
2002: Schilling Joel D; Hultgren Scott J
Recent advances into the pathogenesis of recurrent urinary tract infections: the bladder as a reservoir for uropathogenic Escherichia coli.
International journal of antimicrobial agents 2002;19(6):457-60.
2002: Knight Stefan D; Choudhury Devapriya; Hultgren Scott; Pinkner Jerome; Stojanoff Vivian; Thompson Andrew
Structure of the S pilus periplasmic chaperone SfaE at 2.2 A resolution.
Acta crystallographica. Section D, Biological crystallography 2002;58(Pt 6 Pt 2):1016-22.
2002: Hung Chia-Suei; Bouckaert Julie; Hung Danielle; Pinkner Jerome; Widberg Charlotte; DeFusco Anthony; Auguste C Gale; Strouse Robert; Langermann Solomon; Waksman Gabriel; Hultgren Scott J
Structural basis of tropism of Escherichia coli to the bladder during urinary tract infection.
Molecular microbiology 2002;44(4):903-15.
2002: Mysorekar Indira U; Mulvey Matthew A; Hultgren Scott J; Gordon Jeffrey I
Molecular regulation of urothelial renewal and host defenses during infection with uropathogenic Escherichia coli.
The Journal of biological chemistry 2002;277(9):7412-9.
2002: Chapman Matthew R; Robinson Lloyd S; Pinkner Jerome S; Roth Robyn; Heuser John; Hammar Marten; Normark Staffan; Hultgren Scott J
Role of Escherichia coli curli operons in directing amyloid fiber formation.
Science (New York, N.Y.) 2002;295(5556):851-5.
2002: Martinez Juan J; Hultgren Scott J
Requirement of Rho-family GTPases in the invasion of Type 1-piliated uropathogenic Escherichia coli.
Cellular microbiology 2002;4(1):19-28.
2002: Bann James G; Pinkner Jerome; Hultgren Scott J; Frieden Carl
Real-time and equilibrium (19)F-NMR studies reveal the role of domain-domain interactions in the folding of the chaperone PapD.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(2):709-14.
2001: Svensson A; Larsson A; Emtenäs H; Hedenström M; Fex T; Hultgren S J; Pinkner J S; Almqvist F; Kihlberg J
Design and evaluation of pilicides: potential novel antibacterial agents directed against uropathogenic Escherichia coli.
Chembiochem : a European journal of chemical biology 2001;2(12):915-8.
2001: Mulvey M A; Schilling J D; Hultgren S J
Establishment of a persistent Escherichia coli reservoir during the acute phase of a bladder infection.
Infection and immunity 2001;69(7):4572-9.
2001: Dodson K W; Pinkner J S; Rose T; Magnusson G; Hultgren S J; Waksman G
Structural basis of the interaction of the pyelonephritic E. coli adhesin to its human kidney receptor.
Cell 2001;105(6):733-43.
2001: Schilling J D; Mulvey M A; Hultgren S J
Dynamic interactions between host and pathogen during acute urinary tract infections.
Urology 2001;57(6 Suppl 1):56-61.
2001: Hung D L; Raivio T L; Jones C H; Silhavy T J; Hultgren S J
Cpx signaling pathway monitors biogenesis and affects assembly and expression of P pili.
The EMBO journal 2001;20(7):1508-18.
2001: Schilling J D; Mulvey M A; Hultgren S J
Structure and function of Escherichia coli type 1 pili: new insight into the pathogenesis of urinary tract infections.
The Journal of infectious diseases 2001;183 Suppl 1():S36-40.
2001: Schilling J D; Mulvey M A; Vincent C D; Lorenz R G; Hultgren S J
Bacterial invasion augments epithelial cytokine responses to Escherichia coli through a lipopolysaccharide-dependent mechanism.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(2):1148-55.
2000: Sauer F G; Barnhart M; Choudhury D; Knight S D; Waksman G; Hultgren S J
Chaperone-assisted pilus assembly and bacterial attachment.
Current opinion in structural biology 2000;10(5):548-56.
2000: Mulvey M A; Hultgren S J
Cell biology. Bacterial spelunkers.
Science (New York, N.Y.) 2000;289(5480):732-3.
2000: Mulvey M A; Schilling J D; Martinez J J; Hultgren S J
Bad bugs and beleaguered bladders: interplay between uropathogenic Escherichia coli and innate host defenses.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(16):8829-35.
2000: Saulino E T; Bullitt E; Hultgren S J
Snapshots of usher-mediated protein secretion and ordered pilus assembly.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(16):9240-5.
2000: Emtenäs H; Soto G; Hultgren S J; Marshall G R; Almqvist F
Stereoselective synthesis of optically active beta-lactams, potential inhibitors of pilus assembly in pathogenic bacteria.
Organic letters 2000;2(14):2065-7.
2000: Barnhart M M; Pinkner J S; Soto G E; Sauer F G; Langermann S; Waksman G; Frieden C; Hultgren S J
PapD-like chaperones provide the missing information for folding of pilin proteins.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(14):7709-14.
2000: Martinez J J; Mulvey M A; Schilling J D; Pinkner J S; Hultgren S J
Type 1 pilus-mediated bacterial invasion of bladder epithelial cells.
The EMBO journal 2000;19(12):2803-12.
2000: Sauer F G; Knight S D; Waksman and G J; Hultgren S J
PapD-like chaperones and pilus biogenesis.
Seminars in cell & developmental biology 2000;11(1):27-34.
2000: Sauer F G; Mulvey M A; Schilling J D; Martinez J J; Hultgren S J
Bacterial pili: molecular mechanisms of pathogenesis.
Current opinion in microbiology 2000;3(1):65-72.
2000: Langermann S; Möllby R; Burlein J E; Palaszynski S R; Auguste C G; DeFusco A; Strouse R; Schenerman M A; Hultgren S J; Pinkner J S; Winberg J; Guldevall L; Söderhäll M; Ishikawa K; Normark S; Koenig S
Vaccination with FimH adhesin protects cynomolgus monkeys from colonization and infection by uropathogenic Escherichia coli.
The Journal of infectious diseases 2000;181(2):774-8.
2000: Thanassi D G; Hultgren S J
Assembly of complex organelles: pilus biogenesis in gram-negative bacteria as a model system.
Methods (San Diego, Calif.) 2000;20(1):111-26.
1999: Choudhury D; Thompson A; Stojanoff V; Langermann S; Pinkner J; Hultgren S J; Knight S D
X-ray structure of the FimC-FimH chaperone-adhesin complex from uropathogenic Escherichia coli.
Science (New York, N.Y.) 1999;285(5430):1061-6.
1999: Sauer F G; Fütterer K; Pinkner J S; Dodson K W; Hultgren S J; Waksman G
Structural basis of chaperone function and pilus biogenesis.
Science (New York, N.Y.) 1999;285(5430):1058-61.
1999: Hung D L; Pinkner J S; Knight S D; Hultgren S J
Structural basis of chaperone self-capping in P pilus biogenesis.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(14):8178-83.
1999: Hung D L; Knight S D; Hultgren S J
Probing conserved surfaces on PapD.
Molecular microbiology 1999;31(3):773-83.
1999: Soto G E; Hultgren S J
Bacterial adhesins: common themes and variations in architecture and assembly.
Journal of bacteriology 1999;181(4):1059-71.
1998: Hung D L; Hultgren S J
Pilus biogenesis via the chaperone/usher pathway: an integration of structure and function.
Journal of structural biology 1998;124(2-3):201-20.
1998: Mulvey M A; Lopez-Boado Y S; Wilson C L; Roth R; Parks W C; Heuser J; Hultgren S J
Induction and evasion of host defenses by type 1-piliated uropathogenic Escherichia coli.
Science (New York, N.Y.) 1998;282(5393):1494-7.
1998: Soto G E; Dodson K W; Ogg D; Liu C; Heuser J; Knight S; Kihlberg J; Jones C H; Hultgren S J
Periplasmic chaperone recognition motif of subunits mediates quaternary interactions in the pilus.
The EMBO journal 1998;17(21):6155-67.
1998: Thanassi D G; Saulino E T; Hultgren S J
The chaperone/usher pathway: a major terminal branch of the general secretory pathway.
Current opinion in microbiology 1998;1(2):223-31.
1998: Saulino E T; Thanassi D G; Pinkner J S; Hultgren S J
Ramifications of kinetic partitioning on usher-mediated pilus biogenesis.
The EMBO journal 1998;17(8):2177-85.
1998: Thanassi D G; Saulino E T; Lombardo M J; Roth R; Heuser J; Hultgren S J
The PapC usher forms an oligomeric channel: implications for pilus biogenesis across the outer membrane.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(6):3146-51.
1998: Palaszynski S; Pinkner J; Leath S; Barren P; Auguste C G; Burlein J; Hultgren S; Langermann S
Systemic immunization with conserved pilus-associated adhesins protects against mucosal infections.
Developments in biological standardization 1998;92():117-22.
1997: Jones C H; Danese P N; Pinkner J S; Silhavy T J; Hultgren S J
The chaperone-assisted membrane release and folding pathway is sensed by two signal transduction systems.
The EMBO journal 1997;16(21):6394-406.
1997: Langermann S; Palaszynski S; Barnhart M; Auguste G; Pinkner J S; Burlein J; Barren P; Koenig S; Leath S; Jones C H; Hultgren S J
Prevention of mucosal Escherichia coli infection by FimH-adhesin-based systemic vaccination.
Science (New York, N.Y.) 1997;276(5312):607-11.
1996: Nilsson U; Striker R T; Hultgren S J; Magnusson G
PapG adhesin from E. coli J96 recognizes the same saccharide epitope when present on whole bacteria and as isolated protein.
Bioorganic & medicinal chemistry 1996;4(11):1809-17.
1996: Bullitt E; Jones C H; Striker R; Soto G; Jacob-Dubuisson F; Pinkner J; Wick M J; Makowski L; Hultgren S J
Development of pilus organelle subassemblies in vitro depends on chaperone uncapping of a beta zipper.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(23):12890-5.
1996: St Geme J W; Pinkner J S; Krasan G P; Heuser J; Bullitt E; Smith A L; Hultgren S J
Haemophilus influenzae pili are composite structures assembled via the HifB chaperone.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(21):11913-8.
1996: Hung D L; Knight S D; Woods R M; Pinkner J S; Hultgren S J
Molecular basis of two subfamilies of immunoglobulin-like chaperones.
The EMBO journal 1996;15(15):3792-805.
1995: Striker R; Nilsson U; Stonecipher A; Magnusson G; Hultgren S J
Structural requirements for the glycolipid receptor of human uropathogenic Escherichia coli.
Molecular microbiology 1995;16(5):1021-9.
1995: Xu Z; Jones C H; Haslam D; Pinkner J S; Dodson K; Kihlberg J; Hultgren S J
Molecular dissection of PapD interaction with PapG reveals two chaperone-binding sites.
Molecular microbiology 1995;16(5):1011-20.
1995: Jones C H; Pinkner J S; Roth R; Heuser J; Nicholes A V; Abraham S N; Hultgren S J
FimH adhesin of type 1 pili is assembled into a fibrillar tip structure in the Enterobacteriaceae.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(6):2081-5.
1995: Magnusson G; Hultgren S J; Kihlberg J
Specificity mapping of bacterial lectins by inhibition of hemagglutination using deoxy and deoxyfluoro analogs of receptor-active saccharides.
Methods in enzymology 1995;253():105-14.
1994: Tewari R; Ikeda T; Malaviya R; MacGregor J I; Little J R; Hultgren S J; Abraham S N
The PapG tip adhesin of P fimbriae protects Escherichia coli from neutrophil bactericidal activity.
Infection and immunity 1994;62(12):5296-304.
1994: Jacob-Dubuisson F; Pinkner J; Xu Z; Striker R; Padmanhaban A; Hultgren S J
PapD chaperone function in pilus biogenesis depends on oxidant and chaperone-like activities of DsbA.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(24):11552-6.
1994: Jacob-Dubuisson F; Striker R; Hultgren S J
Chaperone-assisted self-assembly of pili independent of cellular energy.
The Journal of biological chemistry 1994;269(17):12447-55.
1994: Striker R; Jacob-Dubuisson F; Freiden C; Hultgren S J
Stable fiber-forming and nonfiber-forming chaperone-subunit complexes in pilus biogenesis.
The Journal of biological chemistry 1994;269(16):12233-9.
1994: Kuehn M J; Jacob-Dubuisson F; Dodson K; Slonim L; Striker R; Hultgren S J
Genetic, biochemical, and structural studies of biogenesis of adhesive pili in bacteria.
Methods in enzymology 1994;236():282-306.
1993: Kuehn M J; Ogg D J; Kihlberg J; Slonim L N; Flemmer K; Bergfors T; Hultgren S J
Structural basis of pilus subunit recognition by the PapD chaperone.
Science (New York, N.Y.) 1993;262(5137):1234-41.
1993: Jones C H; Pinkner J S; Nicholes A V; Slonim L N; Abraham S N; Hultgren S J
FimC is a periplasmic PapD-like chaperone that directs assembly of type 1 pili in bacteria.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(18):8397-401.
1993: Hultgren S J; Abraham S; Caparon M; Falk P; St Geme J W; Normark S
Pilus and nonpilus bacterial adhesins: assembly and function in cell recognition.
Cell 1993;73(5):887-901.
1993: Jacob-Dubuisson F; Kuehn M; Hultgren S J
A novel secretion apparatus for the assembly of adhesive bacterial pili.
Trends in microbiology 1993;1(2):50-5.
1993: Dodson K W; Jacob-Dubuisson F; Striker R T; Hultgren S J
Outer-membrane PapC molecular usher discriminately recognizes periplasmic chaperone-pilus subunit complexes.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(8):3670-4.
1993: Jacob-Dubuisson F; Heuser J; Dodson K; Normark S; Hultgren S
Initiation of assembly and association of the structural elements of a bacterial pilus depend on two specialized tip proteins.
The EMBO journal 1993;12(3):837-47.
1993: Tewari R; MacGregor J I; Ikeda T; Little J R; Hultgren S J; Abraham S N
Neutrophil activation by nascent FimH subunits of type 1 fimbriae purified from the periplasm of Escherichia coli.
The Journal of biological chemistry 1993;268(4):3009-15.
1993: Hultgren S J; Jacob-Dubuisson F; Jones C H; Bränden C I
PapD and superfamily of periplasmic immunoglobulin-like pilus chaperones.
Advances in protein chemistry 1993;44():99-123.
1992: Slonim L N; Pinkner J S; Brändén C I; Hultgren S J
Interactive surface in the PapD chaperone cleft is conserved in pilus chaperone superfamily and essential in subunit recognition and assembly.
The EMBO journal 1992;11(13):4747-56.
1992: Jones C H; Jacob-Dubuisson F; Dodson K; Kuehn M; Slonim L; Striker R; Hultgren S J
Adhesin presentation in bacteria requires molecular chaperones and ushers.
Infection and immunity 1992;60(11):4445-51.
1992: Holmgren A; Kuehn M J; Brändén C I; Hultgren S J
Conserved immunoglobulin-like features in a family of periplasmic pilus chaperones in bacteria.
The EMBO journal 1992;11(4):1617-22.
1992: Kuehn M J; Heuser J; Normark S; Hultgren S J
P pili in uropathogenic E. coli are composite fibres with distinct fibrillar adhesive tips.
Nature 1992;356(6366):252-5.
1991: Kuehn M J; Normark S; Hultgren S J
Immunoglobulin-like PapD chaperone caps and uncaps interactive surfaces of nascently translocated pilus subunits.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(23):10586-90.
1991: Hultgren S J; Normark S
Biogenesis of the bacterial pilus.
Current opinion in genetics & development 1991;1(3):313-8.
1991: Hultgren S J; Normark S; Abraham S N
Chaperone-assisted assembly and molecular architecture of adhesive pili.
Annual review of microbiology 1991;45():383-415.
1990: Hultgren S J; Duncan J L; Schaeffer A J; Amundsen S K
Mannose-sensitive haemagglutination in the absence of piliation in Escherichia coli.
Molecular microbiology 1990;4(8):1311-8.
1989: Lindberg F; Tennent J M; Hultgren S J; Lund B; Normark S
PapD, a periplasmic transport protein in P-pilus biogenesis.
Journal of bacteriology 1989;171(11):6052-8.
1989: Hultgren S J; Lindberg F; Magnusson G; Kihlberg J; Tennent J M; Normark S
The PapG adhesin of uropathogenic Escherichia coli contains separate regions for receptor binding and for the incorporation into the pilus.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(12):4357-61.
1988: Normark S; Hultgren S; Marklund B I; Strömberg N; Tennent J
Biogenesis of pili adhesins associated with urinary tract infectious Escherichia coli.
Antonie van Leeuwenhoek 1988;54(5):405-9.

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