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David Hume

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Kate Schroder; Colin A Semple; Harukazu Suzuki; Martin S Taylor; Altuna Akalin; John Kenneth Baillie; Nilesh J Bokil; piero carninci; Carsten O Daub; Lynsey Fairbairn; Geoffrey J Faulkner; Nick Goldman; M Milena Gongora; Sean M Grimmond; Yoshihide Hayashizaki; David A Hume; Katharine M Irvine; Ronan Kapetanovic; Hideya Kawaji; Larisa I Labzin; Kim-Anh Le Cao; Boris Lenhard; Kelly-Anne Masterman; Geoffrey J McLachlan; Matthew J Sweet
Conservation and divergence in Toll-like receptor 4-regulated gene expression in primary human versus mouse macrophages.
Maliha A Alikhan; Anthony Beckhouse; James A Deane; Anne L Fletcher; David A Hume; Christina V Jones; Michelle M Kett; Melissa H Little; Robert G Ramsay; Samy Sakkal; Chrishan S Samuel; Christine A Wells; Timothy M Williams; Sharon D Ricardo
Colony-stimulating factor-1 promotes kidney growth and repair via alteration of macrophage responses.
Kylie A Alexander; Ming K Chang; David A Hume; Thomas Kohler; Erin R Maylin; Ralph Müller; Liza J Raggatt; Matthew J Sweet; Nico van Rooijen; Andy C Wu; Allison R Pettit
Osteal macrophages promote in vivo intramembranous bone healing in a mouse tibial injury model.

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All Publications

2012: Kate Schroder; Colin A Semple; Harukazu Suzuki; Martin S Taylor; Altuna Akalin; John Kenneth Baillie; Nilesh J Bokil; piero carninci; Carsten O Daub; Lynsey Fairbairn; Geoffrey J Faulkner; Nick Goldman; M Milena Gongora; Sean M Grimmond; Yoshihide Hayashizaki; David A Hume; Katharine M Irvine; Ronan Kapetanovic; Hideya Kawaji; Larisa I Labzin; Kim-Anh Le Cao; Boris Lenhard; Kelly-Anne Masterman; Geoffrey J McLachlan; Matthew J Sweet
Conservation and divergence in Toll-like receptor 4-regulated gene expression in primary human versus mouse macrophages.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(16):E944-53.
2011: Maliha A Alikhan; Anthony Beckhouse; James A Deane; Anne L Fletcher; David A Hume; Christina V Jones; Michelle M Kett; Melissa H Little; Robert G Ramsay; Samy Sakkal; Chrishan S Samuel; Christine A Wells; Timothy M Williams; Sharon D Ricardo
Colony-stimulating factor-1 promotes kidney growth and repair via alteration of macrophage responses.
The American journal of pathology 2011;179(3):1243-56.
2011: Kylie A Alexander; Ming K Chang; David A Hume; Thomas Kohler; Erin R Maylin; Ralph Müller; Liza J Raggatt; Matthew J Sweet; Nico van Rooijen; Andy C Wu; Allison R Pettit
Osteal macrophages promote in vivo intramembranous bone healing in a mouse tibial injury model.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2011;26(7):1517-32.
2011: Tara L Roberts; Jasmyn A Dunn; Matthew J Sweet; David A Hume; Katryn J Stacey
The immunostimulatory activity of phosphorothioate CpG oligonucleotides is affected by distal sequence changes.
Molecular immunology 2011;48(8):1027-34.
2011: Wendy J van Zuylen; Valerie Garceau; Adi Idris; Kate Schroder; Katharine M Irvine; Jane E Lattin; Dmitry A Ovchinnikov; Andrew C Perkins; Andrew D Cook; John A Hamilton; Paul J Hertzog; Katryn J Stacey; Stuart Kellie; David A Hume; Matthew J Sweet
Macrophage activation and differentiation signals regulate schlafen-4 gene expression: evidence for Schlafen-4 as a modulator of myelopoiesis.
PloS one 2011;6(1):e15723.
2010: Kelli P A MacDonald; James S Palmer; Stephen Cronau; Elke Seppanen; Stuart Olver; Neil C Raffelt; Rachel D Kuns; Allison R Pettit; Andrew D Clouston; Brandon J Wainwright; Dan Branstetter; Jeffrey Smith; Raymond J Paxton; Douglas Pat Cerretti; Lynn Bonham; Geoffrey R Hill; David A Hume
An antibody against the colony-stimulating factor 1 receptor depletes the resident subset of monocytes and tissue- and tumor-associated macrophages but does not inhibit inflammation.
Blood 2010;116(19):3955-63.
2010: Atsutaka Kubosaki; Gabriella Lindgren; Michihira Tagami; Christophe Simon; Yasuhiro Tomaru; Hisashi Miura; Takahiro Suzuki; Erik Arner; Alistair R R Forrest; Katharine M Irvine; Kate Schroder; Yuki Hasegawa; Mutsumi Kanamori-Katayama; Michael Rehli; David A Hume; Jun Kawai; Masanori Suzuki; Harukazu Suzuki; Yoshihide Hayashizaki
The combination of gene perturbation assay and ChIP-chip reveals functional direct target genes for IRF8 in THP-1 cells.
Molecular immunology 2010;47(14):2295-302.
2010: Maria A Halili; Melanie R Andrews; Larisa I Labzin; Kate Schroder; Gabriele Matthias; Chun Cao; Erica Lovelace; Robert C Reid; Giang T Le; David A Hume; Katharine M Irvine; Patrick Matthias; David P Fairlie; Matthew J Sweet
Differential effects of selective HDAC inhibitors on macrophage inflammatory responses to the Toll-like receptor 4 agonist LPS.
Journal of leukocyte biology 2010;87(6):1103-14.
2010: Dmitry A Ovchinnikov; Claire E E DeBats; David P Sester; Matthew J Sweet; David A Hume
A conserved distal segment of the mouse CSF-1 receptor promoter is required for maximal expression of a reporter gene in macrophages and osteoclasts of transgenic mice.
Journal of leukocyte biology 2010;87(5):815-22.
2010: Jane E Weber; Aaron J Oakley; Angelika N Christ; Alan G Clark; John D Hayes; Rhonda Hall; David A Hume; Philip G Board; Mark L Smythe; Jack U Flanagan
Identification and characterisation of new inhibitors for the human hematopoietic prostaglandin D2 synthase.
European journal of medicinal chemistry 2010;45(2):447-54.
2010: Jane E Mooney; Barbara E Rolfe; Geoffrey W Osborne; David P Sester; Nico van Rooijen; Gordon R Campbell; David A Hume; Julie H Campbell
Cellular plasticity of inflammatory myeloid cells in the peritoneal foreign body response.
The American journal of pathology 2010;176(1):369-80.
2009: Jane E Lattin; Kathryn P Greenwood; Norelle L Daly; Gregory Kelly; David A Zidar; Richard J Clark; Walter G Thomas; Stuart Kellie; David J Craik; David A Hume; Matthew J Sweet
Beta-arrestin 2 is required for complement C1q expression in macrophages and constrains factor-independent survival.
Molecular immunology 2009;47(2-3):340-7.
2009: Stefanie Ebert; Karin Weigelt; Yana Walczak; Wolfgang Drobnik; Richard Mauerer; David A Hume; Bernhard H F Weber; Thomas Langmann
Docosahexaenoic acid attenuates microglial activation and delays early retinal degeneration.
Journal of neurochemistry 2009;110(6):1863-75.
2009: Felicia Goh; Katharine M Irvine; Erica Lovelace; Sheila Donnelly; Malcolm K Jones; Kristian Brion; David A Hume; Andrew C Kotze; John P Dalton; Aaron Ingham; Matthew J Sweet
Selective induction of the Notch ligand Jagged-1 in macrophages by soluble egg antigen from Schistosoma mansoni involves ERK signalling.
Immunology 2009;127(3):326-37.
2009: Richa K Dave; David A Hume; Caryn Elsegood; Stuart Kellie
CD148/DEP-1 association with areas of cytoskeletal organisation in macrophages.
Experimental cell research 2009;315(10):1734-44.
2009: Ryan J Taft; Evgeny Glazov; Nicole Cloonan; Cas Simons; Stuart Stephen; Geoffrey J Faulkner; Timo Lassmann; Alistair Forrest; Sean M Grimmond; Kate Schroder; Katharine M Irvine; Takahiro Arakawa; Mari Nakamura; Atsutaka Kubosaki; Kengo Hayashida; Chika Kawazu; Mitsuyoshi Murata; Hiromi Nishiyori; Shiro Fukuda; Jun Kawai; Carsten O Daub; David A Hume; Harukazu Suzuki; Valerio Orlando; piero carninci; Yoshihide Hayashizaki; John S Mattick
Tiny RNAs associated with transcription start sites in animals.
Nature genetics 2009;41(5):572-8.
2009: Geoffrey J Faulkner; Yasumasa Kimura; Carsten O Daub; Shivangi Wani; Charles Plessy; Katharine M Irvine; Kate Schroder; Nicole Cloonan; Anita L Steptoe; Timo Lassmann; Kazunori Waki; Nadine Hornig; Takahiro Arakawa; Hazuki Takahashi; Jun Kawai; Alistair Forrest; Harukazu Suzuki; Yoshihide Hayashizaki; David A Hume; Valerio Orlando; Sean M Grimmond; piero carninci
The regulated retrotransposon transcriptome of mammalian cells.
Nature genetics 2009;41(5):563-71.
2009: Angela Trieu; Nilesh Bokil; Jasmyn A Dunn; Tara L Roberts; Damo Xu; Foo Y Liew; David A Hume; Katryn J Stacey; Matthew J Sweet
TLR9-independent effects of inhibitory oligonucleotides on macrophage responses to S. typhimurium.
Immunology and cell biology 2009;87(3):218-25.
2009: Tara L Roberts; Adi Idris; Jasmyn A Dunn; Greg M Kelly; Carol M Burnton; Samantha Hodgson; Lani L Hardy; Valerie Garceau; Matthew J Sweet; Ian L Ross; David A Hume; Katryn J Stacey
HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA.
Science (New York, N.Y.) 2009;323(5917):1057-60.
2009: Katharine M Irvine; Melanie R Andrews; Manuel A Fernandez-Rojo; Kate Schroder; Christopher J Burns; Stephen Su; Andrew F Wilks; Robert Parton; David A Hume; Matthew J Sweet
Colony-stimulating factor-1 (CSF-1) delivers a proatherogenic signal to human macrophages.
Journal of leukocyte biology 2009;85(2):278-88.
2008: Allison R Pettit; Ming K Chang; David A Hume; Liza-Jane Raggatt
Osteal macrophages: a new twist on coupling during bone dynamics.
Bone 2008;43(6):976-82.
2008: Ming K Chang; Liza-Jane Raggatt; Kylie A Alexander; Julia S Kuliwaba; Nicola Fazzalari; Kate Schroder; Erin R Maylin; Vera M Ripoll; David A Hume; Allison R Pettit
Osteal tissue macrophages are intercalated throughout human and mouse bone lining tissues and regulate osteoblast function in vitro and in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(2):1232-44.
2008: Gordon J King; Alun Jones; Bostjan Kobe; Thomas Huber; Dmitri Mouradov; David A Hume; Ian L Ross
Identification of disulfide-containing chemical cross-links in proteins using MALDI-TOF/TOF-mass spectrometry.
Analytical chemistry 2008;80(13):5036-43.
2008: Nathan P Cowieson; Gordon King; David Cookson; Ian Ross; Thomas Huber; David A Hume; Bostjan Kobe; Jennifer L Martin
Cortactin adopts a globular conformation and bundles actin into sheets.
The Journal of biological chemistry 2008;283(23):16187-93.
2008: Christine A Wells; Judith Salvage-jones; Xin Li; Kelly Jane Hitchens; Suzanne Butcher; Rachael Z Murray; Anthony Beckhouse; Yu-Lan-Sandra Lo; Silvia Manzanero; Christian Cobbold; Kate Schroder; Bo Ma; Sally Orr; Lauren Stewart; Daniel Lebus; Peter Sobieszczuk; David A Hume; Jennifer Stow; Helen Blanchard; Robert B Ashman
The macrophage-inducible C-type lectin, mincle, is an essential component of the innate immune response to Candida albicans.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(11):7404-13.
2008: David A Hume; Tedjo Sasmono; S Roy Himes; Sudarshana Sharma; Agnieszka Bronisz; Myrna Constantin; Michael C Ostrowski; Ian L Ross
The Ewing sarcoma protein (EWS) binds directly to the proximal elements of the macrophage-specific promoter of the CSF-1 receptor (csf1r) gene.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(10):6733-42.
2008: Vera M Ripoll; Nicholas A Meadows; Liza-Jane Raggatt; Ming K Chang; Allison R Pettit; A Ian Cassady; David A Hume
Microphthalmia transcription factor regulates the expression of the novel osteoclast factor GPNMB.
Gene 2008;413(1-2):32-41.
2008: Geoffrey J Faulkner; Alistair Forrest; Alistair Chalk; Kate Schroder; Yoshihide Hayashizaki; piero carninci; David A Hume; Sean M Grimmond
A rescue strategy for multimapping short sequence tags refines surveys of transcriptional activity by CAGE.
Genomics 2008;91(3):281-8.
2008: Dmitry A Ovchinnikov; Wendy J M van Zuylen; Claire E E DeBats; Kylie A Alexander; Stuart Kellie; David A Hume
Expression of Gal4-dependent transgenes in cells of the mononuclear phagocyte system labeled with enhanced cyan fluorescent protein using Csf1r-Gal4VP16/UAS-ECFP double-transgenic mice.
Journal of leukocyte biology 2008;83(2):430-3.
2008: Kieran S Hadler; Thomas Huber; A Ian Cassady; Jane Weber; Jodie Robinson; Allan Burrows; Gregory Kelly; Luke W Guddat; David A Hume; Gerhard Schenk; Jack U Flanagan
Identification of a non-purple tartrate-resistant acid phosphatase: an evolutionary link to Ser/Thr protein phosphatases?
BMC research notes 2008;1():78.
2008: Weining Meng; Jade K Forwood; Gregor Guncar; Gautier Robin; Nathan P Cowieson; Pawel Listwan; Dmitri Mouradov; Gordon King; Ian L Ross; Jodie Robinson; Munish Puri; Justine M Hill; Stuart Kellie; Thomas Huber; David A Hume; Jennifer L Martin; Bostjan Kobe
Overview of the pipeline for structural and functional characterization of macrophage proteins at the university of queensland.
Methods in molecular biology (Clifton, N.J.) 2008;426():577-87.
2008: Dmitri Mouradov; Gordon King; Ian L Ross; Jade K Forwood; David A Hume; Andrea Sinz; Jennifer L Martin; Bostjan Kobe; Thomas Huber
Protein structure determination using a combination of cross-linking, mass spectrometry, and molecular modeling.
Methods in molecular biology (Clifton, N.J.) 2008;426():459-74.
2008: Nathan P Cowieson; Beth Wensley; Gautier Robin; Gregor Guncar; Jade Forwood; David A Hume; Bostjan Kobe; Jennifer L Martin
A medium or high throughput protein refolding assay.
Methods in molecular biology (Clifton, N.J.) 2008;426():269-75.
2008: Gautier Robin; Nathan P Cowieson; Gregor Guncar; Jade K Forwood; Pawel Listwan; David A Hume; Bostjan Kobe; Jennifer L Martin; Thomas Huber
A general target selection method for crystallographic proteomics.
Methods in molecular biology (Clifton, N.J.) 2008;426():27-35.
2008: Jane E Lattin; Kate Schroder; Andrew I Su; John R Walker; Jie Zhang; Tim Wiltshire; Kaoru Saijo; Christopher K Glass; David A Hume; Stuart Kellie; Matthew J Sweet
Expression analysis of G Protein-Coupled Receptors in mouse macrophages.
Immunome research 2008;4():5.
2007: Rebecca A Hinshelwood; Lily I Huschtscha; John R Melki; Clare Stirzaker; Andrea Abdipranoto; Bryce Vissel; Timothy Ravasi; Christine A Wells; David A Hume; Roger R Reddel; Susan J Clark
Concordant epigenetic silencing of transforming growth factor-beta signaling pathway genes occurs early in breast carcinogenesis.
Cancer research 2007;67(24):11517-27.
2007: Timothy Ravasi; Christine A Wells; David A Hume
Systems biology of transcription control in macrophages.
BioEssays : news and reviews in molecular, cellular and developmental biology 2007;29(12):1215-26.
2007: Konrad A Bode; Kate Schroder; David A Hume; Timothy Ravasi; Klaus Heeg; Matthew J Sweet; Alexander H Dalpke
Histone deacetylase inhibitors decrease Toll-like receptor-mediated activation of proinflammatory gene expression by impairing transcription factor recruitment.
Immunology 2007;122(4):596-606.
2007: Séverine Ouvry-Patat; Severine A Ouvry Patat; John B Carlin; Keith Grimwood; Alun Jones; David S Armstrong; John C Galati; Peter J Cooper; Catherine Ann Byrnes; Paul W Francis; Colin F Robertson; David A Hume; Christoph H Borchers; Claire E Wainwright; Brandon J Wainwright
Novel neutrophil-derived proteins in bronchoalveolar lavage fluid indicate an exaggerated inflammatory response in pediatric cystic fibrosis patients.
Clinical chemistry 2007;53(10):1782-91.
2007: Kate Schroder; Martina Spille; Andreas Pilz; Jane Lattin; Konrad A Bode; Katharine M Irvine; Allan D Burrows; Timothy Ravasi; Heike Weighardt; Katryn J Stacey; Thomas Decker; David A Hume; Alexander H Dalpke; Matthew J Sweet
Differential effects of CpG DNA on IFN-beta induction and STAT1 activation in murine macrophages versus dendritic cells: alternatively activated STAT1 negatively regulates TLR signaling in macrophages.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(6):3495-503.
2007: Fiona Rae; Kyra Woods; Tedjo Sasmono; Naomi Campanale; Darrin Taylor; Dmitry A Ovchinnikov; Sean M Grimmond; David A Hume; Sharon D Ricardo; Melissa H Little
Characterisation and trophic functions of murine embryonic macrophages based upon the use of a Csf1r-EGFP transgene reporter.
Developmental biology 2007;308(1):232-46.
2007: Jane Lattin; David A Zidar; Kate Schroder; Stuart Kellie; David A Hume; Matthew J Sweet
G-protein-coupled receptor expression, function, and signaling in macrophages.
Journal of leukocyte biology 2007;82(1):16-32.
2007: R Tedjo Sasmono; Achim Ehrnsperger; Stephen L Cronau; Timothy Ravasi; Rangi Kandane; Michael J Hickey; Andrew D Cook; S Roy Himes; John A Hamilton; David A Hume
Mouse neutrophilic granulocytes express mRNA encoding the macrophage colony-stimulating factor receptor (CSF-1R) as well as many other macrophage-specific transcripts and can transdifferentiate into macrophages in vitro in response to CSF-1.
Journal of leukocyte biology 2007;82(1):111-23.
2007: Jade K Forwood; Anil S Thakur; Gregor Guncar; Mary Marfori; Dmitri Mouradov; Weining Meng; Jodie Robinson; Thomas Huber; Stuart Kellie; Jennifer L Martin; David A Hume; Bostjan Kobe
Structural basis for recruitment of tandem hotdog domains in acyl-CoA thioesterase 7 and its role in inflammation.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(25):10382-7.
2007: Kate Schroder; Monika Lichtinger; Katharine M Irvine; Kristian Brion; Angela Trieu; Ian L Ross; Timothy Ravasi; Katryn J Stacey; Michael Rehli; David A Hume; Matthew J Sweet
PU.1 and ICSBP control constitutive and IFN-gamma-regulated Tlr9 gene expression in mouse macrophages.
Journal of leukocyte biology 2007;81(6):1577-90.
2007: Vera M Ripoll; Katharine M Irvine; Timothy Ravasi; Matthew J Sweet; David A Hume
Gpnmb is induced in macrophages by IFN-gamma and lipopolysaccharide and acts as a feedback regulator of proinflammatory responses.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(10):6557-66.
2007: Nicholas A Meadows; Sudarshana Sharma; Geoffrey J Faulkner; Michael C Ostrowski; David A Hume; A Ian Cassady
The expression of Clcn7 and Ostm1 in osteoclasts is coregulated by microphthalmia transcription factor.
The Journal of biological chemistry 2007;282(3):1891-904.
2007: David A Hume; Christine A Wells; Timothy Ravasi
Transcriptional regulatory networks in macrophages.
Novartis Foundation symposium 2007;281():2-18; discussion 18-24, 50-3, 208-9.
2006: Munish Puri; Gautier Robin; Nathan P Cowieson; Jade K Forwood; Pawel Listwan; Shu-Hong Hu; Gregor Guncar; Thomas Huber; Stuart Kellie; David A Hume; Bostjan Kobe; Jennifer L Martin
Focusing in on structural genomics: the University of Queensland structural biology pipeline.
Biomolecular engineering 2006;23(6):281-9.
2006: Mareike Kurz; Nathan P Cowieson; Gautier Robin; David A Hume; Jennifer L Martin; Bostjan Kobe; Pawel Listwan
Incorporating a TEV cleavage site reduces the solubility of nine recombinant mouse proteins.
Protein expression and purification 2006;50(1):68-73.
2006: David P Sester; Kristian Brion; Angela Trieu; Helen Goodridge; Tara L Roberts; Jasmyn Dunn; David A Hume; Katryn J Stacey; Matthew J Sweet
CpG DNA activates survival in murine macrophages through TLR9 and the phosphatidylinositol 3-kinase-Akt pathway.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(7):4473-80.
2006: Katharine M Irvine; Christopher J Burns; Andrew F Wilks; Stephen Su; David A Hume; Matthew J Sweet
A CSF-1 receptor kinase inhibitor targets effector functions and inhibits pro-inflammatory cytokine production from murine macrophage populations.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(11):1921-3.
2006: Andy C K Wu; Lisbeth Grøndahl; Kevin S Jack; Michelle X Foo; Matt Trau; David A Hume; A Ian Cassady
Reduction of the in vitro pro-inflammatory response by macrophages to poly(3-hydroxybutyrate-co-3-hydroxyvalerate).
Biomaterials 2006;27(27):4715-25.
2006: Jack U Flanagan; A Ian Cassady; Gerhard Schenk; Luke W Guddat; David A Hume
Identification and molecular modeling of a novel, plant-like, human purple acid phosphatase.
Gene 2006;377():12-20.
2006: Hnin Thanda Aung; Kate Schroder; S Roy Himes; Kristian Brion; Wendy van Zuylen; Angela Trieu; Harukazu Suzuki; Yoshihide Hayashizaki; David A Hume; Matthew J Sweet; Timothy Ravasi
LPS regulates proinflammatory gene expression in macrophages by altering histone deacetylase expression.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(9):1315-27.
2006: Nathan P Cowieson; Beth Wensley; Pawel Listwan; David A Hume; Bostjan Kobe; Jennifer L Martin
An automatable screen for the rapid identification of proteins amenable to refolding.
Proteomics 2006;6(6):1750-7.
2006: S Roy Himes; David P Sester; Timothy Ravasi; Stephen L Cronau; Tedjo Sasmono; David A Hume
The JNK are important for development and survival of macrophages.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(4):2219-28.
2006: Robert Serek; Jade K Forwood; David A Hume; Jennifer L Martin; Bostjan Kobe
Crystallization of the C-terminal domain of the mouse brain cytosolic long-chain acyl-CoA thioesterase.
Acta crystallographica. Section F, Structural biology and crystallization communications 2006;62(Pt 2):133-5.
2006: David A Hume
The mononuclear phagocyte system.
Current opinion in immunology 2006;18(1):49-53.
2006: Sudarshana Sharma; Rong Hu; Agnieszka Bronisz; Nicolas Meadows; Tricia Lusby; Barbara Fletcher; David A Hume; A Ian Cassady; Michael C Ostrowski
Genetics and genomics of osteoclast differentiation: integrating cell signaling pathways and gene networks.
Critical reviews in eukaryotic gene expression 2006;16(3):253-77.
2006: Kate Schroder; Matthew J Sweet; David A Hume
Signal integration between IFNgamma and TLR signalling pathways in macrophages.
Immunobiology 2006;211(6-8):511-24.
2006: Christine A Wells; Alistair Chalk; Alistair Forrest; Darrin Taylor; Nic Waddell; Kate Schroder; S Roy Himes; Geoffrey J Faulkner; Sandra Lo; Takeya Kasukawa; Hideya Kawaji; Chikatoshi Kai; Jun Kawai; Shintaro Katayama; piero carninci; Yoshihide Hayashizaki; David A Hume; Sean M Grimmond
Alternate transcription of the Toll-like receptor signaling cascade.
Genome biology 2006;7(2):R10.
2006: Timothy Ravasi; Harukazu Suzuki; Ken C Pang; Shintaro Katayama; Masaaki Furuno; Rie Okunishi; Shiro Fukuda; Kelin Ru; Martin C Frith; M Milena Gongora; Sean M Grimmond; David A Hume; Yoshihide Hayashizaki; John S Mattick
Experimental validation of the regulated expression of large numbers of non-coding RNAs from the mouse genome.
Genome research 2006;16(1):11-9.
2006: Dmitri Mouradov; Ari Craven; Jade K Forwood; Jack U Flanagan; Raquel García-Castellanos; F Xavier Gomis-Rüth; David A Hume; Jennifer L Martin; Bostjan Kobe; Thomas Huber
Modelling the structure of latexin-carboxypeptidase A complex based on chemical cross-linking and molecular docking.
Protein engineering, design & selection : PEDS 2006;19(1):9-16.
2005: Anita L Cochrane; Michelle M Kett; Chrishan S Samuel; Naomi V Campanale; Warwick P Anderson; David A Hume; Melissa H Little; John F Bertram; Sharon D Ricardo
Renal structural and functional repair in a mouse model of reversal of ureteral obstruction.
Journal of the American Society of Nephrology : JASN 2005;16(12):3623-30.
2005: Pawel Listwan; Nathan P Cowieson; Mareike Kurz; David A Hume; Jennifer L Martin; Bostjan Kobe
Modification of recombinatorial cloning for small affinity tag fusion protein construct generation.
Analytical biochemistry 2005;346(2):327-9.
2005: Tara L Roberts; Jasmyn A Dunn; Tamsin D Terry; Michael P Jennings; David A Hume; Matthew J Sweet; Katryn J Stacey
Differences in macrophage activation by bacterial DNA and CpG-containing oligonucleotides.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(6):3569-76.
2005: S Roy Himes; Stephen L Cronau; Christine Mulford; David A Hume
The Runx1 transcription factor controls CSF-1-dependent and -independent growth and survival of macrophages.
Oncogene 2005;24(34):5278-86.
2005: Kelli P A MacDonald; Vanessa Rowe; Helen M Bofinger; Ranjeny Thomas; Tedjo Sasmono; David A Hume; Geoffrey R Hill
The colony-stimulating factor 1 receptor is expressed on dendritic cells during differentiation and regulates their expansion.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(3):1399-405.
2005: Natasa Mitić; Mohsen Valizadeh; Eleanor W W Leung; John de Jersey; Susan Hamilton; David A Hume; A Ian Cassady; Gerhard Schenk
Human tartrate-resistant acid phosphatase becomes an effective ATPase upon proteolytic activation.
Archives of biochemistry and biophysics 2005;439(2):154-64.
2005: Christine A Wells; Timothy Ravasi; David A Hume
Inflammation suppressor genes: please switch out all the lights.
Journal of leukocyte biology 2005;78(1):9-13.
2005: Michael Rehli; Sabine Sulzbacher; Sabine Pape; Timothy Ravasi; Christine A Wells; Sven Heinz; Liane Söllner; Carol El Chartouni; Stefan W Krause; Eirikur Steingrimsson; David A Hume; Reinhard Andreesen
Transcription factor Tfec contributes to the IL-4-inducible expression of a small group of genes in mouse macrophages including the granulocyte colony-stimulating factor receptor.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(11):7111-22.
2005: Rachael Z Murray; Fiona G Wylie; Tatiana Khromykh; David A Hume; Jennifer L Stow
Syntaxin 6 and Vti1b form a novel SNARE complex, which is up-regulated in activated macrophages to facilitate exocytosis of tumor necrosis Factor-alpha.
The Journal of biological chemistry 2005;280(11):10478-83.
2005: Anna Aagaard; Pawel Listwan; Nathan P Cowieson; Thomas Huber; Timothy Ravasi; Christine A Wells; Jack U Flanagan; Stuart Kellie; David A Hume; Bostjan Kobe; Jennifer L Martin
An inflammatory role for the mammalian carboxypeptidase inhibitor latexin: relationship to cystatins and the tumor suppressor TIG1.
Structure (London, England : 1993) 2005;13(2):309-17.
2005: Tara L Roberts; Matthew J Sweet; David A Hume; Katryn J Stacey
Cutting edge: species-specific TLR9-mediated recognition of CpG and non-CpG phosphorothioate-modified oligonucleotides.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(2):605-8.
2005: David A Hume; David P Fairlie
Therapeutic targets in inflammatory disease.
Current medicinal chemistry 2005;12(25):2925-9.
2005: David P Sester; Angela Trieu; Kristian Brion; Kate Schroder; Timothy Ravasi; Jodie A Robinson; Rebecca C McDonald; Vera Ripoll; Christine A Wells; Harukazu Suzuki; Yoshihide Hayashizaki; Katryn J Stacey; David A Hume; Matthew J Sweet
LPS regulates a set of genes in primary murine macrophages by antagonising CSF-1 action.
Immunobiology 2005;210(2-4):97-107.
2005: Nathan P Cowieson; Pawel Listwan; Mareike Kurz; Anna Aagaard; Timothy Ravasi; Christine Wells; Thomas Huber; David A Hume; Bostjan Kobe; Jennifer L Martin
Pilot studies on the parallel production of soluble mouse proteins in a bacterial expression system.
Journal of structural and functional genomics 2005;6(1):13-20.
2004: Takeya Kasukawa; Shintaro Katayama; Hideya Kawaji; Harukazu Suzuki; David A Hume; Yoshihide Hayashizaki
Construction of representative transcript and protein sets of human, mouse, and rat as a platform for their transcriptome and proteome analysis.
Genomics 2004;84(6):913-21.
2004: Timothy Ravasi; Kenneth Hsu; Jesse Goyette; Kate Schroder; Zheng Yang; Ahmed Farid Rahimi; Les P Miranda; Paul F Alewood; David A Hume; Carolyn L Geczy
Probing the S100 protein family through genomic and functional analysis.
Genomics 2004;84(1):10-22.
2004: Mohsen Valizadeh; Gerhard Schenk; Kevin Nash; Geoff W Oddie; Luke W Guddat; David A Hume; John de Jersey; Terrence R Burke; Susan Hamilton
Phosphotyrosyl peptides and analogues as substrates and inhibitors of purple acid phosphatases.
Archives of biochemistry and biophysics 2004;424(2):154-62.
2004: Kate Schroder; Paul J Hertzog; Timothy Ravasi; David A Hume
Interferon-gamma: an overview of signals, mechanisms and functions.
Journal of leukocyte biology 2004;75(2):163-89.
2003: A Ian Cassady; Alexander Luchin; Michael C Ostrowski; David A Hume
Regulation of the murine TRACP gene promoter.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2003;18(10):1901-4.
2003: Brendan J McMorran; L Town; EO Costelloe; J Palmer; J Engel; David A Hume; Brandon J Wainwright
Effector ExoU from the type III secretion system is an important modulator of gene expression in lung epithelial cells in response to Pseudomonas aeruginosa infection.
Infection and immunity 2003;71(10):6035-44.
2003: Christine A Wells; Timothy Ravasi; Geoffrey J Faulkner; piero carninci; Yasushi Okazaki; Yoshihide Hayashizaki; Matthew J Sweet; Brandon J Wainwright; David A Hume
Genetic control of the innate immune response.
BMC immunology 2003;4():5.
2003: Takeya Kasukawa; Masaaki Furuno; Itoshi Nikaido; Hidemasa Bono; David A Hume; Carol Bult; David P Hill; Richard Baldarelli; Julian Gough; Alexander Kanapin; Hideo Matsuda; Lynn M Schriml; Yoshihide Hayashizaki; Yasushi Okazaki; John Quackenbush
Development and evaluation of an automated annotation pipeline and cDNA annotation system.
Genome research 2003;13(6B):1542-51.
2003: Alistair Forrest; Timothy Ravasi; Darrin Taylor; Thomas Huber; David A Hume; Sean M Grimmond
Phosphoregulators: protein kinases and protein phosphatases of mouse.
Genome research 2003;13(6B):1443-54.
2003: Timothy Ravasi; Thomas Huber; Mihaela Zavolan; Alistair Forrest; Terry Gaasterland; Sean M Grimmond; David A Hume
Systematic characterization of the zinc-finger-containing proteins in the mouse transcriptome.
Genome research 2003;13(6B):1430-42.
2003: Khairina Tajul-Arifin; Rohan Teasdale; Timothy Ravasi; David A Hume; John S Mattick
Identification and analysis of chromodomain-containing proteins encoded in the mouse transcriptome.
Genome research 2003;13(6B):1416-29.
2003: Christine A Wells; Timothy Ravasi; Razvan Sultana; Ken Yagi; piero carninci; Hidemasa Bono; Geoffrey J Faulkner; Yasushi Okazaki; John Quackenbush; David A Hume; Paul A Lyons
Continued discovery of transcriptional units expressed in cells of the mouse mononuclear phagocyte lineage.
Genome research 2003;13(6B):1360-5.
2003: Sean M Grimmond; Kevin C Miranda; Zheng Yuan; Melissa J Davis; David A Hume; Ken Yagi; Naoko Tominaga; Hidemasa Bono; Yoshihide Hayashizaki; Yasushi Okazaki; Rohan Teasdale
The mouse secretome: functional classification of the proteins secreted into the extracellular environment.
Genome research 2003;13(6B):1350-9.
2003: Hidemasa Bono; Ken Yagi; Takeya Kasukawa; Itoshi Nikaido; Naoko Tominaga; Rika Miki; Yosuke Mizuno; Yasuhiro Tomaru; Hitoshi Goto; Hiroyuki Nitanda; Daisuke Shimizu; Hirochika Makino; Tomoyuki Morita; Junshin Fujiyama; Takehito Sakai; Takashi Shimoji; David A Hume; Yoshihide Hayashizaki; Yasushi Okazaki
Systematic expression profiling of the mouse transcriptome using RIKEN cDNA microarrays.
Genome research 2003;13(6B):1318-23.
2003: Katryn J Stacey; Greg R Young; Francis Clark; David P Sester; Tara L Roberts; Shalin Naik; Matthew J Sweet; David A Hume
The molecular basis for the lack of immunostimulatory activity of vertebrate DNA.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(7):3614-20.
2003: Nicole C Walsh; Marian Cahill; piero carninci; Jun Kawai; Yasushi Okazaki; Yoshihide Hayashizaki; David A Hume; A Ian Cassady
Multiple tissue-specific promoters control expression of the murine tartrate-resistant acid phosphatase gene.
Gene 2003;307():111-23.
2003: R Tedjo Sasmono; Delvac Oceandy; Jeffrey W Pollard; Wei Tong; Paul Pavli; Brandon J Wainwright; Michael C Ostrowski; S Roy Himes; David A Hume
A macrophage colony-stimulating factor receptor-green fluorescent protein transgene is expressed throughout the mononuclear phagocyte system of the mouse.
Blood 2003;101(3):1155-63.
2003: Matthew J Sweet; David A Hume
CSF-1 as a regulator of macrophage activation and immune responses.
Archivum immunologiae et therapiae experimentalis 2003;51(3):169-77.
2002: David A Hume; Ian L Ross; S Roy Himes; R Tedjo Sasmono; Christine A Wells; Timothy Ravasi
The mononuclear phagocyte system revisited.
Journal of leukocyte biology 2002;72(4):621-7.
2002: Delvac Oceandy; Brendan J McMorran; Stephen N Smith; Rainer Schreiber; Karl Kunzelmann; Eric W F W Alton; David A Hume; Brandon J Wainwright
Gene complementation of airway epithelium in the cystic fibrosis mouse is necessary and sufficient to correct the pathogen clearance and inflammatory abnormalities.
Human molecular genetics 2002;11(9):1059-67.
2002: Kim C Mansky; Sabine Sulzbacher; Georgia H Purdom; Lori Nelsen; David A Hume; Michael Rehli; Michael C Ostrowski
The microphthalmia transcription factor and the related helix-loop-helix zipper factors TFE-3 and TFE-C collaborate to activate the tartrate-resistant acid phosphatase promoter.
Journal of leukocyte biology 2002;71(2):304-10.
2002: Kim C Mansky; Kavita Marfatia; Georgia H Purdom; Alexander Luchin; David A Hume; Michael C Ostrowski
The microphthalmia transcription factor (MITF) contains two N-terminal domains required for transactivation of osteoclast target promoters and rescue of mi mutant osteoclasts.
Journal of leukocyte biology 2002;71(2):295-303.
2002: S L Wardrop; C Wells; Timothy Ravasi; David A Hume; Des R Richardson
Induction of Nramp2 in activated mouse macrophages is dissociated from regulation of the Nramp1, classical inflammatory genes, and genes involved in iron metabolism.
Journal of leukocyte biology 2002;71(1):99-106.
2002: Matthew J Sweet; Carol C Campbell; David P Sester; Damo Xu; Rebecca C McDonald; Katryn J Stacey; David A Hume; Foo Y Liew
Colony-stimulating factor-1 suppresses responses to CpG DNA and expression of toll-like receptor 9 but enhances responses to lipopolysaccharide in murine macrophages.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(1):392-9.
2002: Timothy Ravasi; Christine Wells; Alistair Forrest; David M Underhill; Brandon J Wainwright; Alan Aderem; Sean M Grimmond; David A Hume
Generation of diversity in the innate immune system: macrophage heterogeneity arises from gene-autonomous transcriptional probability of individual inducible genes.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(1):44-50.
2001: S Roy Himes; Hiromi Tagoh; N Goonetilleke; Tedjo Sasmono; Delvac Oceandy; R Clark; Constanze Bonifer; David A Hume
A highly conserved c-fms gene intronic element controls macrophage-specific and regulated expression.
Journal of leukocyte biology 2001;70(5):812-20.
2001: Alexander Luchin; S Suchting; Tobias Merson; Thomas J Rosol; David A Hume; A Ian Cassady; Michael C Ostrowski
Genetic and physical interactions between Microphthalmia transcription factor and PU.1 are necessary for osteoclast gene expression and differentiation.
The Journal of biological chemistry 2001;276(39):36703-10.
2001: Brendan J McMorran; James S Palmer; D P Lunn; Delvac Oceandy; EO Costelloe; G R Thomas; David A Hume; Brandon J Wainwright
G551D CF mice display an abnormal host response and have impaired clearance of Pseudomonas lung disease.
American journal of physiology. Lung cellular and molecular physiology 2001;281(3):L740-7.
2001: David A Hume; David M Underhill; Matthew J Sweet; Adrian Ozinsky; F Y Liew; Alan Aderem
Macrophages exposed continuously to lipopolysaccharide and other agonists that act via toll-like receptors exhibit a sustained and additive activation state.
BMC immunology 2001;2():11.
2000: G W Oddie; Gerhard Schenk; NZ Angel; Nicole Walsh; Luke W Guddat; John de Jersey; A Ian Cassady; Susan E Hamilton; David A Hume
Structure, function, and regulation of tartrate-resistant acid phosphatase.
Bone 2000;27(5):575-84.
2000: J L Smith; Alicia Erbe Schaffner; J K Hofmeister; M Hartman; Guo Wei; David J Forsthoefel; David A Hume; Michael C Ostrowski
ets-2 is a target for an akt (Protein kinase B)/jun N-terminal kinase signaling pathway in macrophages of motheaten-viable mutant mice.
Molecular and cellular biology 2000;20(21):8026-34.
2000: David P Sester; Shalin Naik; SJ Beasley; David A Hume; Katryn J Stacey
Phosphorothioate backbone modification modulates macrophage activation by CpG DNA.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(8):4165-73.
2000: David A Hume
Probability in transcriptional regulation and its implications for leukocyte differentiation and inducible gene expression.
Blood 2000;96(7):2323-8.
2000: Gerhard Schenk; Michael L J Korsinczky; David A Hume; Susan Hamilton; J DeJersey
Purple acid phosphatases from bacteria: similarities to mammalian and plant enzymes.
Gene 2000;255(2):419-24.
2000: Gerhard Schenk; Luke W Guddat; Yubin Ge; Lyle E Carrington; David A Hume; Susan Hamilton; John de Jersey
Identification of mammalian-like purple acid phosphatases in a wide range of plants.
Gene 2000;250(1-2):117-25.
2000: Wenda Shurety; A Merino-Trigo; D Brown; David A Hume; Jennifer L Stow
Localization and post-Golgi trafficking of tumor necrosis factor-alpha in macrophages.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2000;20(4):427-38.
2000: Lindsay F Fowles; Katryn J Stacey; D Marks; J A Hamilton; David A Hume
Regulation of urokinase plasminogen activator gene transcription in the RAW264 murine macrophage cell line by macrophage colony-stimulating factor (CSF-1) is dependent upon the level of cell-surface receptor.
The Biochemical journal 2000;347 Pt 1():313-20.
2000: G R Thomas; E A Costelloe; D P Lunn; Katryn J Stacey; S J Delaney; Robert J Passey; Edwina McGlinn; Brendan J McMorran; A Ahadizadeh; Carolyn L Geczy; Brandon J Wainwright; David A Hume
G551D cystic fibrosis mice exhibit abnormal regulation of inflammation in lungs and macrophages.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(7):3870-7.
2000: Alexander Luchin; Georgia H Purdom; K Murphy; M Y Clark; NZ Angel; A Ian Cassady; David A Hume; Michael C Ostrowski
The microphthalmia transcription factor regulates expression of the tartrate-resistant acid phosphatase gene during terminal differentiation of osteoclasts.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2000;15(3):451-60.
2000: Adrian Ozinsky; Kelly D Smith; David A Hume; David M Underhill
Co-operative induction of pro-inflammatory signaling by Toll-like receptors.
Journal of endotoxin research 2000;6(5):393-6.
2000: Katryn J Stacey; David P Sester; Matthew J Sweet; David A Hume
Macrophage activation by immunostimulatory DNA.
Current topics in microbiology and immunology 2000;247():41-58.
2000: NZ Angel; Nicole Walsh; Mark R Forwood; Michael C Ostrowski; A Ian Cassady; David A Hume
Transgenic mice overexpressing tartrate-resistant acid phosphatase exhibit an increased rate of bone turnover.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2000;15(1):103-10.
1999: David P Sester; SJ Beasley; Matthew J Sweet; Lindsay F Fowles; Stephen L Cronau; Katryn J Stacey; David A Hume
Bacterial/CpG DNA down-modulates colony stimulating factor-1 receptor surface expression on murine bone marrow-derived macrophages with concomitant growth arrest and factor-independent survival.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(12):6541-50.
1999: Robert J Passey; K Xu; David A Hume; Carolyn L Geczy
S100A8: emerging functions and regulation.
Journal of leukocyte biology 1999;66(4):549-56.
1999: David P Sester; Katryn J Stacey; Matthew J Sweet; SJ Beasley; Stephen L Cronau; David A Hume
The actions of bacterial DNA on murine macrophages.
Journal of leukocyte biology 1999;66(4):542-8.
1999: S Chang; Katryn J Stacey; J Chen; EO Costelloe; A Aderem; David A Hume
Mechanisms of regulation of the MacMARCKS gene in macrophages by bacterial lipopolysaccharide.
Journal of leukocyte biology 1999;66(3):528-34.
1999: Robert J Passey; E Williams; A M Lichanska; C Wells; S Hu; Carolyn L Geczy; M H Little; David A Hume
A null mutation in the inflammation-associated S100 protein S100A8 causes early resorption of the mouse embryo.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(4):2209-16.
1999: Luke W Guddat; A S McAlpine; David A Hume; John de Jersey; Susan Hamilton; Jennifer L Martin
Crystallization and preliminary X-ray diffraction studies of mammalian purple acid phosphatase.
Acta crystallographica. Section D, Biological crystallography 1999;55(Pt 8):1462-4.
1999: Luke W Guddat; A S McAlpine; David A Hume; Susan Hamilton; John de Jersey; Jennifer L Martin
Crystal structure of mammalian purple acid phosphatase.
Structure (London, England : 1993) 1999;7(7):757-67.
1999: EO Costelloe; Katryn J Stacey; Toni M Antalis; David A Hume
Regulation of the plasminogen activator inhibitor-2 (PAI-2) gene in murine macrophages. Demonstration of a novel pattern of responsiveness to bacterial endotoxin.
Journal of leukocyte biology 1999;66(1):172-82.
1999: Agnieszka M Lichanska; Catherine Browne; Gregory W Henkel; K M Murphy; Michael C Ostrowski; Scott R McKercher; Richard A Maki; David A Hume
Differentiation of the mononuclear phagocyte system during mouse embryogenesis: the role of transcription factor PU.1.
Blood 1999;94(1):127-38.
1999: D K Kakuda; Matthew J Sweet; C L Mac Leod; David A Hume; Daniel Markovich
CAT2-mediated L-arginine transport and nitric oxide production in activated macrophages.
The Biochemical journal 1999;340 ( Pt 2)():549-53.
1999: Michael Rehli; Nicole R den Elzen; A Ian Cassady; Michael C Ostrowski; David A Hume
Cloning and characterization of the murine genes for bHLH-ZIP transcription factors TFEC and TFEB reveal a common gene organization for all MiT subfamily members.
Genomics 1999;56(1):111-20.
1999: Michael Rehli; Agnieszka M Lichanska; A Ian Cassady; Michael C Ostrowski; David A Hume
TFEC is a macrophage-restricted member of the microphthalmia-TFE subfamily of basic helix-loop-helix leucine zipper transcription factors.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(3):1559-65.
1999: Bobby Joseph; S C Marks; David A Hume; Michael J Waters; Anne L Symons
Insulin-like growth factor-I (IGF-I) and IGF-I receptor (IGF-IR) immunoreactivity in normal and osteopetrotic (toothless, tl/tl) rat tibia.
Growth factors (Chur, Switzerland) 1999;16(4):279-91.
1998: J M Osborne; Nicole R den Elzen; Agnieszka M Lichanska; EO Costelloe; T Yamada; A Ian Cassady; David A Hume
Murine DEP-1, a receptor protein tyrosine phosphatase, is expressed in macrophages and is regulated by CSF-1 and LPS.
Journal of leukocyte biology 1998;64(5):692-701.
1998: Lindsay F Fowles; M L Martin; Lori Nelsen; Katryn J Stacey; D Redd; Y M Clark; Y Nagamine; M McMahon; David A Hume; Michael C Ostrowski
Persistent activation of mitogen-activated protein kinases p42 and p44 and ets-2 phosphorylation in response to colony-stimulating factor 1/c-fms signaling.
Molecular and cellular biology 1998;18(9):5148-56.
1998: Matthew J Sweet; Katryn J Stacey; D K Kakuda; Daniel Markovich; David A Hume
IFN-gamma primes macrophage responses to bacterial DNA.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1998;18(4):263-71.
1998: Ian L Ross; X Yue; Michael C Ostrowski; David A Hume
Interaction between PU.1 and another Ets family transcription factor promotes macrophage-specific Basal transcription initiation.
The Journal of biological chemistry 1998;273(12):6662-9.
1998: Matthew J Sweet; Katryn J Stacey; Ian L Ross; Michael C Ostrowski; David A Hume
Involvement of Ets, rel and Sp1-like proteins in lipopolysaccharide-mediated activation of the HIV-1 LTR in macrophages.
Journal of inflammation 1998;48(2):67-83.
1997: K Marshall; K Nash; G Haussman; I Cassady; David A Hume; John de Jersey; Susan Hamilton
Recombinant human and mouse purple acid phosphatases: expression and characterization.
Archives of biochemistry and biophysics 1997;345(2):230-6.
1997: David A Hume; X Yue; Ian L Ross; P Favot; Agnieszka M Lichanska; Michael C Ostrowski
Regulation of CSF-1 receptor expression.
Molecular reproduction and development 1997;46(1):46-52; discussion 52-3.
1996: T L Dunn; Ian L Ross; David A Hume
Transcription factor Oct-2 is expressed in primary murine macrophages.
Blood 1996;88(10):4072.
1996: X Yue; Ian L Ross; Catherine Browne; Agnieszka M Lichanska; P Favot; Michael C Ostrowski; David A Hume
Transcriptional control of the expression of the c-fms gene encoding the receptor for macrophage colony-stimulating factor (CSF-1).
Immunobiology 1996;195(4-5):461-76.
1996: Katryn J Stacey; Matthew J Sweet; David A Hume
Macrophages ingest and are activated by bacterial DNA.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(5):2116-22.
1996: Matthew J Sweet; David A Hume
Endotoxin signal transduction in macrophages.
Journal of leukocyte biology 1996;60(1):8-26.
1996: Matthew J Sweet; David A Hume
Bacterial lipopolysaccharide confers resistance to G418, doxorubicin, and taxol in the murine macrophage cell line, RAW264.
Journal of leukocyte biology 1996;59(2):280-6.
1996: B S Yang; C A Hauser; Gregory W Henkel; M S Colman; C Van Beveren; Katryn J Stacey; David A Hume; Richard A Maki; Michael C Ostrowski
Ras-mediated phosphorylation of a conserved threonine residue enhances the transactivation activities of c-Ets1 and c-Ets2.
Molecular and cellular biology 1996;16(2):538-47.
1996: Anne L Symons; C A MacKay; K Leong; David A Hume; M J Waters; S C Marks
Decreased growth hormone receptor expression in long bones from toothless (osteopetrotic) rats and restoration by treatment with colony-stimulating factor-1.
Growth factors (Chur, Switzerland) 1996;13(1-2):1-10.
1995: P Favot; X Yue; David A Hume
Regulation of the c-fms promoter in murine tumour cell lines.
Oncogene 1995;11(7):1371-81.
1995: C Chen; RW Clarkson; Y Xie; David A Hume; M J Waters
Growth hormone and colony-stimulating factor 1 share multiple response elements in the c-fos promoter.
Endocrinology 1995;136(10):4505-16.
1995: David A Hume; S J Monkley; Brandon J Wainwright
Detection of c-fms protooncogene in early mouse embryos by whole mount in situ hybridization indicates roles for macrophages in tissue remodelling.
British journal of haematology 1995;90(4):939-42.
1995: Katryn J Stacey; Lindsay F Fowles; M S Colman; Michael C Ostrowski; David A Hume
Regulation of urokinase-type plasminogen activator gene transcription by macrophage colony-stimulating factor.
Molecular and cellular biology 1995;15(6):3430-41.
1995: David A Hume; P Favot
Is the osteopetrotic (op/op mutant) mouse completely deficient in expression of macrophage colony-stimulating factor?
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1995;15(4):279-84.
1995: Matthew J Sweet; David A Hume
RAW264 macrophages stably transfected with an HIV-1 LTR reporter gene provide a sensitive bioassay for analysis of signalling pathways in macrophages stimulated with lipopolysaccharide, TNF-alpha or taxol.
Journal of inflammation 1995;45(2):126-35.
1994: Katryn J Stacey; Y Nagamine; David A Hume
RNA synthesis inhibition stabilises urokinase mRNA in macrophages.
FEBS letters 1994;356(2-3):311-3.
1994: M A Reddy; B S Yang; X Yue; C J Barnett; Ian L Ross; Matthew J Sweet; David A Hume; Michael C Ostrowski
Opposing actions of c-ets/PU.1 and c-myb protooncogene products in regulating the macrophage-specific promoters of the human and mouse colony-stimulating factor-1 receptor (c-fms) genes.
The Journal of experimental medicine 1994;180(6):2309-19.
1994: K M Murphy; Matthew J Sweet; David A Hume
The HIV-1 regulatory protein Nef has a specific function in viral expression in a murine macrophage cell line.
Journal of leukocyte biology 1994;56(3):294-303.
1994: Ian L Ross; Catherine Browne; David A Hume
Transcription of individual genes in eukaryotic cells occurs randomly and infrequently.
Immunology and cell biology 1994;72(2):177-85.
1994: Ian L Ross; T L Dunn; X Yue; Sandrine Roy; C J Barnett; David A Hume
Comparison of the expression and function of the transcription factor PU.1 (Spi-1 proto-oncogene) between murine macrophages and B lymphocytes.
Oncogene 1994;9(1):121-32.
1993: K M Murphy; Matthew J Sweet; Ian L Ross; David A Hume
Effects of the tat and nef gene products of human immunodeficiency virus type 1 (HIV-1) on transcription controlled by the HIV-1 long terminal repeat and on cell growth in macrophages.
Journal of virology 1993;67(12):6956-64.
1993: A Ian Cassady; A G King; N C Cross; David A Hume
Isolation and characterization of the genes encoding mouse and human type-5 acid phosphatase.
Gene 1993;130(2):201-7.
1993: Y Xie; S von Gavel; A Ian Cassady; Katryn J Stacey; T L Dunn; David A Hume
The resistance of macrophage-like tumour cell lines to growth inhibition by lipopolysaccharide and pertussis toxin.
British journal of haematology 1993;84(3):392-401.
1993: X Yue; P Favot; T L Dunn; A Ian Cassady; David A Hume
Expression of mRNA encoding the macrophage colony-stimulating factor receptor (c-fms) is controlled by a constitutive promoter and tissue-specific transcription elongation.
Molecular and cellular biology 1993;13(6):3191-201.
1993: Katryn J Stacey; Ian L Ross; David A Hume
Electroporation and DNA-dependent cell death in murine macrophages.
Immunology and cell biology 1993;71 ( Pt 2)():75-85.
1993: P Pavli; David A Hume; E Van De Pol; WF Doe
Dendritic cells, the major antigen-presenting cells of the human colonic lamina propria.
Immunology 1993;78(1):132-41.
1992: F Le; Peter A Wilce; David A Hume; B C Shanley
Involvement of gamma-aminobutyric acid and N-methyl-D-aspartate receptors in the inhibitory effect of ethanol on pentylenetetrazole-induced c-fos expression in rat brain.
Journal of neurochemistry 1992;59(4):1309-15.
1992: David A Hume; Y Denkins
The deleterious effect of macrophage colony-stimulating factor (CSF-1) on the pathology of experimental candidiasis in mice.
Lymphokine and cytokine research 1992;11(2):95-8.
1992: H S Warren; M J Hodder; W Allan; David A Hume; Charmaine J Simeonovic
Induction of class II major histocompatibility antigens on thyroid, adult pancreatic islet, and fetal proislet allografts.
Transplantation 1992;53(4):834-40.
1992: A G Doyle; W J Halliday; C J Barnett; T L Dunn; David A Hume
Effect of recombinant human macrophage colony-stimulating factor 1 on immunopathology of experimental brucellosis in mice.
Infection and immunity 1992;60(4):1465-72.
1991: A Ian Cassady; Katryn J Stacey; K A Nimmo; K M Murphy; D von der Ahe; D Pearson; F M Botteri; Y Nagamine; David A Hume
Constitutive expression of the urokinase plasminogen activator gene in murine RAW264 macrophages involves distal and 5' non-coding sequences that are conserved between mouse and pig.
Nucleic acids research 1991;19(24):6839-47.
1991: F N Breen; David A Hume; M J Weidemann
Interactions among granulocyte-macrophage colony-stimulating factor, macrophage colony-stimulating factor, and IFN-gamma lead to enhanced proliferation of murine macrophage progenitor cells.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(5):1542-7.
1991: A H Abd; N W Savage; W J Halliday; David A Hume
The role of macrophages in experimental arthritis induced by Streptococcus agalactiae sonicate: actions of macrophage colony-stimulating factor (CSF-1) and other macrophage-modulating agents.
Lymphokine and cytokine research 1991;10(1-2):43-50.
1991: F Le; Peter A Wilce; I Cassady; David A Hume; B C Shanley
Acute administration of ethanol suppresses pentylenetetrazole-induced c-fos expression in rat brain.
Alcohol and alcoholism (Oxford, Oxfordshire). Supplement 1991;1():211-4.
1990: F Le; Peter A Wilce; I Cassady; David A Hume; B Shanley
Acute administration of ethanol suppresses pentylenetetrazole-induced c-fos expression in rat brain.
Neuroscience letters 1990;120(2):271-4.
1990: P Pavli; C E Woodhams; WF Doe; David A Hume
Isolation and characterization of antigen-presenting dendritic cells from the mouse intestinal lamina propria.
Immunology 1990;70(1):40-7.
1990: F N Breen; David A Hume; M J Weidemann
The effects of interleukin 3 (IL-3) on cells responsive to macrophage colony-stimulating factor (CSF-1) in liquid murine bone marrow culture.
British journal of haematology 1990;74(2):138-45.
1990: A H Abd; David A Hume; W J Halliday; G H Davis
Immunopathological investigations during the course of arthritis induced in rats by Streptococcus agalactiae.
Medical microbiology and immunology 1990;179(1):13-23.
1989: David A Hume; Y M Denkins
Activation of macrophages to express cytocidal activity correlates with inhibition of their responsiveness to macrophage colony-stimulating factor (CSF-1): involvement of a pertussis toxin-sensitive reaction.
Immunology and cell biology 1989;67 ( Pt 4)():243-9.
1989: David A Hume; R E Donahue; Isaiah J Fidler
The therapeutic effect of human recombinant macrophage colony stimulating factor (CSF-1) in experimental murine metastatic melanoma.
Lymphokine research 1989;8(1):69-77.
1989: David A Hume; R Nayar
Encapsulation is not involved in the activities of recombinant gamma interferon associated with multilamellar phospholipid liposomes on murine bone marrow-derived macrophages.
Lymphokine research 1989;8(4):415-25.
1988: David A Hume; P Pavli; R E Donahue; Isaiah J Fidler
The effect of human recombinant macrophage colony-stimulating factor (CSF-1) on the murine mononuclear phagocyte system in vivo.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(10):3405-9.
1988: Charmaine J Simeonovic; M J Hodder; David A Hume
Role of Ia-positive leukocytes and F4/80-positive macrophages in the immunogenicity of fetal mouse proislets and fetal pancreas.
Transplantation proceedings 1988;20(1):68-71.
1987: David A Hume; W Allan; P G Hogan; WF Doe
Immunohistochemical characterisation of macrophages in human liver and gastrointestinal tract: expression of CD4, HLA-DR, OKM1, and the mature macrophage marker 25F9 in normal and diseased tissue.
Journal of leukocyte biology 1987;42(5):474-84.
1987: H S Warren; Charmaine J Simeonovic; W Allan; David A Hume
Induced expression of class II major histocompatibility complex antigens on thyroid but not pancreatic islet allografts following transfer of sensitized LYT2+ T cells.
Transplantation proceedings 1987;19(1 Pt 1):213.
1987: David A Hume; W Allan; B Fabrus; M J Weidemann; A J Hapel; Stephen Bartelmez
Regulation of proliferation of bone marrow-derived macrophages.
Lymphokine research 1987;6(2):127-39.
1985: David A Hume; W Allan; J Golder; Ross W Stephens; WF Doe; H S Warren
Preparation and characterization of human bone marrow-derived macrophages.
Journal of leukocyte biology 1985;38(4):541-52.
1985: Ross W Stephens; J P Golder; D R Fayle; David A Hume; A J Hapel; W Allan; C J Fordham; WF Doe
Minactivin expression in human monocyte and macrophage populations.
Blood 1985;66(2):333-7.
1985: A J Hapel; J M Osborne; Ming-Chiu Fung; Ian G Young; W Allan; David A Hume
Expression of 20-alpha-hydroxysteroid dehydrogenase in mouse macrophages, hemopoietic cells, and cell lines and its induction by colony-stimulating factors.
Journal of immunology (Baltimore, Md. : 1950) 1985;134(4):2492-7.