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Martin Humphries

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Chemicals & Drugs

Physiology

Phenomena

Protein Binding

Genes & Molecular Sequences

Amino Acid Sequence

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Anatomy

Cultured Tumor Cells

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Co-Publications
Name
44
Mould, Paul
23
Askari, Janet
21
Tuckwell, Danny
13
Craig, Susan
12
Newham, Peter
10
Humphries, Jonathan
8
Bass, Mark
7
Buckley, Patrick
7
Mostafavi-Pour, Zohreh
6
Morgan, Mark
6
Messent, Anthea
6
Barton, Stephanie
6
Travis, Mark
6
Garratt, Alistair
5
Ng, Tony

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Publications

TOP 3
Byron Adam; Humphries Jonathan D; Askari Janet A; Craig Sue E; Mould A Paul; Humphries Martin J
Anti-integrin monoclonal antibodies.
Morgan Mark R; Byron Adam; Humphries Martin J; Bass Mark D
Giving off mixed signals--distinct functions of alpha5beta1 and alphavbeta3 integrins in regulating cell behaviour.
Deakin Nicholas O; Bass Mark D; Warwood Stacey; Schoelermann Julia; Mostafavi-Pour Zohreh; Knight David; Ballestrem Christoph; Humphries Martin J
An integrin-alpha4-14-3-3zeta-paxillin ternary complex mediates localised Cdc42 activity and accelerates cell migration.

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All Publications

2009: Byron Adam; Humphries Jonathan D; Askari Janet A; Craig Sue E; Mould A Paul; Humphries Martin J
Anti-integrin monoclonal antibodies.
Journal of cell science 2009;122(Pt 22):4009-11.
2009: Morgan Mark R; Byron Adam; Humphries Martin J; Bass Mark D
Giving off mixed signals--distinct functions of alpha5beta1 and alphavbeta3 integrins in regulating cell behaviour.
IUBMB life 2009;61(7):731-8.
2009: Deakin Nicholas O; Bass Mark D; Warwood Stacey; Schoelermann Julia; Mostafavi-Pour Zohreh; Knight David; Ballestrem Christoph; Humphries Martin J
An integrin-alpha4-14-3-3zeta-paxillin ternary complex mediates localised Cdc42 activity and accelerates cell migration.
Journal of cell science 2009;122(Pt 10):1654-64.
2009: Bass Mark D; Morgan Mark R; Humphries Martin J
Syndecans shed their reputation as inert molecules.
Science signaling 2009;2(64):pe18.
2009: Mahoney Claire M; Morgan Mark R; Harrison Andrew; Humphries Martin J; Bass Mark D
Therapeutic ultrasound bypasses canonical syndecan-4 signaling to activate rac1.
The Journal of biological chemistry 2009;284(13):8898-909.
2009: Askari Janet A; Buckley Patrick A; Mould A Paul; Humphries Martin J
Linking integrin conformation to function.
Journal of cell science 2009;122(Pt 2):165-70.
2009: Humphries Jonathan D; Byron Adam; Bass Mark D; Craig Sue E; Pinney John W; Knight David; Humphries Martin J
Proteomic analysis of integrin-associated complexes identifies RCC2 as a dual regulator of Rac1 and Arf6.
Science signaling 2009;2(87):ra51.
2009: Humphries Martin J
Cell adhesion assays.
Methods in molecular biology (Clifton, N.J.) 2009;522():203-10.
2008: Valdramidou Dimitra; Humphries Martin J; Mould A Paul
Distinct roles of beta1 metal ion-dependent adhesion site (MIDAS), adjacent to MIDAS (ADMIDAS), and ligand-associated metal-binding site (LIMBS) cation-binding sites in ligand recognition by integrin alpha2beta1.
The Journal of biological chemistry 2008;283(47):32704-14.
2008: Bass Mark D; Morgan Mark R; Roach Kirsty A; Settleman Jeffrey; Goryachev Andrew B; Humphries Martin J
p190RhoGAP is the convergence point of adhesion signals from alpha 5 beta 1 integrin and syndecan-4.
The Journal of cell biology 2008;181(6):1013-26.
2008: Parsons Maddy; Messent Anthea J; Humphries Jonathan D; Deakin Nicholas O; Humphries Martin J
Quantification of integrin receptor agonism by fluorescence lifetime imaging.
Journal of cell science 2008;121(Pt 3):265-71.
2007: Humphries Jonathan D; Wang Pengbo; Streuli Charles; Geiger Benny; Humphries Martin J; Ballestrem Christoph
Vinculin controls focal adhesion formation by direct interactions with talin and actin.
The Journal of cell biology 2007;179(5):1043-57.
2007: Morgan Mark R; Humphries Martin J; Bass Mark D
Synergistic control of cell adhesion by integrins and syndecans.
Nature reviews. Molecular cell biology 2007;8(12):957-69.
2007: Caswell Patrick T; Spence Heather J; Parsons Maddy; White Dominic P; Clark Katherine; Cheng Kwai Wa; Mills Gordon B; Humphries Martin J; Messent Anthea J; Anderson Kurt I; McCaffrey Mary W; Ozanne Bradford W; Norman Jim C
Rab25 associates with alpha5beta1 integrin to promote invasive migration in 3D microenvironments.
Developmental cell 2007;13(4):496-510.
2007: Askari Janet A; Thornton David J; Humphries Jonathan D; Buckley Patrick A; Humphries Martin J
The alternatively spliced type III connecting segment of fibronectin is a zinc-binding module.
Matrix biology : journal of the International Society for Matrix Biology 2007;26(6):485-93.
2007: Gardiner Natalie J; Moffatt Sarah; Fernyhough Paul; Humphries Martin J; Streuli Charles H; Tomlinson David R
Preconditioning injury-induced neurite outgrowth of adult rat sensory neurons on fibronectin is mediated by mobilisation of axonal alpha5 integrin.
Molecular and cellular neurosciences 2007;35(2):249-60.
2007: Bass Mark D; Roach Kirsty A; Morgan Mark R; Mostafavi-Pour Zohreh; Schoen Tobias; Muramatsu Takashi; Mayer Ulrike; Ballestrem Christoph; Spatz Joachim P; Humphries Martin J
Syndecan-4-dependent Rac1 regulation determines directional migration in response to the extracellular matrix.
The Journal of cell biology 2007;177(3):527-38.
2007: Bax Daniel V; Mahalingam Yashithra; Cain Stuart; Mellody Kieran; Freeman Lyle; Younger Kerri; Shuttleworth C Adrian; Humphries Martin J; Couchman John R; Kielty Cay M
Cell adhesion to fibrillin-1: identification of an Arg-Gly-Asp-dependent synergy region and a heparin-binding site that regulates focal adhesion formation.
Journal of cell science 2007;120(Pt 8):1383-92.
2007: Humphries Jonathan D; Humphries Martin J
CD14 is a ligand for the integrin alpha4beta1.
FEBS letters 2007;581(4):757-63.
2007: Watson P Marc D; Humphries Martin J; Relton Jane; Rothwell Nancy J; Verkhratsky Alex; Gibson Rosemary M
Integrin-binding RGD peptides induce rapid intracellular calcium increases and MAPK signaling in cortical neurons.
Molecular and cellular neurosciences 2007;34(2):147-54.
2006: Sumathipala Rushika; Xu Cunshuan; Seago Julian; Mould A Paul; Humphries Martin J; Craig Sue E; Patel Yatin; Wijelath Errol S; Sobel Michael; Rahman Salman
The "linker" region (amino acids 38-47) of the disintegrin elegantin is a novel inhibitory domain of integrin alpha5beta1-dependent cell adhesion on fibronectin: evidence for the negative regulation of fibronectin synergy site biological activity.
The Journal of biological chemistry 2006;281(49):37686-96.
2006: Wijelath Errol S; Rahman Salman; Namekata Mayumi; Murray Jacqueline; Nishimura Tomoaki; Mostafavi-Pour Zohreh; Patel Yatin; Suda Yasuo; Humphries Martin J; Sobel Michael
Heparin-II domain of fibronectin is a vascular endothelial growth factor-binding domain: enhancement of VEGF biological activity by a singular growth factor/matrix protein synergism.
Circulation research 2006;99(8):853-60.
2006: Humphries Jonathan D; Byron Adam; Humphries Martin J
Integrin ligands at a glance.
Journal of cell science 2006;119(Pt 19):3901-3.
2006: Mould A Paul; McLeish Jennifer A; Huxley-Jones Julie; Goonesinghe Alexander C; Hurlstone Adam F L; Boot-Handford Raymond P; Humphries Martin J
Identification of multiple integrin beta1 homologs in zebrafish (Danio rerio).
BMC cell biology 2006;7():24.
2005: Gläsner Joachim; Blum Horst; Wehner Volkmar; Stilz Hans Ulrich; Humphries Jonathan D; Curley G Paul; Mould A Paul; Humphries Martin J; Hallmann Rupert; Röllinghoff Martin; Gessner André
A small molecule alpha 4 beta 1 antagonist prevents development of murine Lyme arthritis without affecting protective immunity.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(7):4724-34.
2005: Gibson Rosemary M; Craig Susan E; Heenan Laura; Tournier Cathy; Humphries Martin J
Activation of integrin alpha5beta1 delays apoptosis of Ntera2 neuronal cells.
Molecular and cellular neurosciences 2005;28(3):588-98.
2005: Humphries Jonathan D; Schofield Neil R; Mostafavi-Pour Zohreh; Green Linda J; Garratt Alistair N; Mould A Paul; Humphries Martin J
Dual functionality of the anti-beta1 integrin antibody, 12G10, exemplifies agonistic signalling from the ligand binding pocket of integrin adhesion receptors.
The Journal of biological chemistry 2005;280(11):10234-43.
2005: Mould A Paul; Travis Mark A; Barton Stephanie J; Hamilton Jennifer A; Askari Janet A; Craig Susan E; Macdonald Philip R; Kammerer Richard A; Buckley Patrick A; Humphries Martin J
Evidence that monoclonal antibodies directed against the integrin beta subunit plexin/semaphorin/integrin domain stimulate function by inducing receptor extension.
The Journal of biological chemistry 2005;280(6):4238-46.
2005: Clark Katherine; Pankov Roumen; Travis Mark A; Askari Janet A; Mould A Paul; Craig Susan E; Newham Peter; Yamada Kenneth M; Humphries Martin J
A specific alpha5beta1-integrin conformation promotes directional integrin translocation and fibronectin matrix formation.
Journal of cell science 2005;118(Pt 2):291-300.
2005: Humphries Martin J; Mostafavi-Pour Zohreh; Morgan Mark R; Deakin Nicholas O; Messent Anthea J; Bass Mark D
Integrin-syndecan cooperation governs the assembly of signalling complexes during cell spreading.
Novartis Foundation symposium 2005;269():178-88; discussion 188-92, 223-30.
2005: Ewan Richard; Huxley-Jones Julie; Mould A Paul; Humphries Martin J; Robertson David L; Boot-Handford Raymond P
The integrins of the urochordate Ciona intestinalis provide novel insights into the molecular evolution of the vertebrate integrin family.
BMC evolutionary biology 2005;5(1):31.
2004: Humphries M J; Travis M A; Clark K; Mould A P
Mechanisms of integration of cells and extracellular matrices by integrins.
Biochemical Society transactions 2004;32(Pt 5):822-5.
2004: Zhang Xiaohui; Craig Susan E; Kirby Hishani; Humphries Martin J; Moy Vincent T
Molecular basis for the dynamic strength of the integrin alpha4beta1/VCAM-1 interaction.
Biophysical journal 2004;87(5):3470-8.
2004: Mould A Paul; Humphries Martin J
Regulation of integrin function through conformational complexity: not simply a knee-jerk reaction?
Current opinion in cell biology 2004;16(5):544-51.
2004: Travis Mark A; van der Flier Arjan; Kammerer Richard A; Mould A Paul; Sonnenberg Arnoud; Humphries Martin J
Interaction of filamin A with the integrin beta 7 cytoplasmic domain: role of alternative splicing and phosphorylation.
FEBS letters 2004;569(1-3):185-90.
2004: Humphries M J
Monoclonal antibodies as probes of integrin priming and activation.
Biochemical Society transactions 2004;32(Pt3):407-11.
2004: Barton Stephanie J; Travis Mark A; Askari Janet A; Buckley Patrick A; Craig Susan E; Humphries Martin J; Mould A Paul
Novel activating and inactivating mutations in the integrin beta1 subunit A domain.
The Biochemical journal 2004;380(Pt 2):401-7.
2004: Bax Daniel V; Messent Anthea J; Tart Jonathan; van Hoang Mien; Kott Jane; Maciewicz Rose A; Humphries Martin J
Integrin alpha5beta1 and ADAM-17 interact in vitro and co-localize in migrating HeLa cells.
The Journal of biological chemistry 2004;279(21):22377-86.
2003: Mould A Paul; Barton Stephanie J; Askari Janet A; Craig Susan E; Humphries Martin J
Role of ADMIDAS cation-binding site in ligand recognition by integrin alpha 5 beta 1.
The Journal of biological chemistry 2003;278(51):51622-9.
2003: Mould A Paul; Symonds Emlyn J H; Buckley Patrick A; Grossmann J Günter; McEwan Paul A; Barton Stephanie J; Askari Janet A; Craig Susan E; Bella Jordi; Humphries Martin J
Structure of an integrin-ligand complex deduced from solution x-ray scattering and site-directed mutagenesis.
The Journal of biological chemistry 2003;278(41):39993-9.
2003: Bax Daniel V; Bernard Sarah E; Lomas Amanda; Morgan Amanda; Humphries Jon; Shuttleworth C Adrian; Humphries Martin J; Kielty Cay M
Cell adhesion to fibrillin-1 molecules and microfibrils is mediated by alpha 5 beta 1 and alpha v beta 3 integrins.
The Journal of biological chemistry 2003;278(36):34605-16.
2003: Humphries Martin J; McEwan Paul A; Barton Stephanie J; Buckley Patrick A; Bella Jordi; Mould A Paul
Integrin structure: heady advances in ligand binding, but activation still makes the knees wobble.
Trends in biochemical sciences 2003;28(6):313-20.
2003: Mould A Paul; Barton Stephanie J; Askari Janet A; McEwan Paul A; Buckley Patrick A; Craig Susan E; Humphries Martin J
Conformational changes in the integrin beta A domain provide a mechanism for signal transduction via hybrid domain movement.
The Journal of biological chemistry 2003;278(19):17028-35.
2003: Humphries Martin J; Symonds Emlyn J H; Mould A Paul
Mapping functional residues onto integrin crystal structures.
Current opinion in structural biology 2003;13(2):236-43.
2003: Travis Mark A; Humphries Jonathan D; Humphries Martin J
An unraveling tale of how integrins are activated from within.
Trends in pharmacological sciences 2003;24(4):192-7.
2003: Mostafavi-Pour Zohreh; Askari Janet A; Parkinson Scott J; Parker Peter J; Ng Tony T C; Humphries Martin J
Integrin-specific signaling pathways controlling focal adhesion formation and cell migration.
The Journal of cell biology 2003;161(1):155-67.
2002: Bass Mark D; Humphries Martin J
Cytoplasmic interactions of syndecan-4 orchestrate adhesion receptor and growth factor receptor signalling.
The Biochemical journal 2002;368(Pt 1):1-15.
2002: Whittard John D; Craig Susan E; Mould A Paul; Koch Alexander; Pertz Olivier; Engel Jürgen; Humphries Martin J
E-cadherin is a ligand for integrin alpha2beta1.
Matrix biology : journal of the International Society for Matrix Biology 2002;21(6):525-32.
2002: Parsons Maddy; Keppler Melanie D; Kline Adam; Messent Anthea; Humphries Martin J; Gilchrist Ruth; Hart Ian R; Quittau-Prevostel Corinne; Hughes William E; Parker Peter J; Ng Tony
Site-directed perturbation of protein kinase C- integrin interaction blocks carcinoma cell chemotaxis.
Molecular and cellular biology 2002;22(16):5897-911.
2002: Mould A Paul; Askari Janet A; Barton Stephanie; Kline Adam D; McEwan Paul A; Craig Susan E; Humphries Martin J
Integrin activation involves a conformational change in the alpha 1 helix of the beta subunit A-domain.
The Journal of biological chemistry 2002;277(22):19800-5.
2002: Aquilina Alexis; Korda Michelle; Bergelson Jeffrey M; Humphries Martin J; Farndale Richard W; Tuckwell Danny
A novel gain-of-function mutation of the integrin alpha2 VWFA domain.
European journal of biochemistry / FEBS 2002;269(4):1136-44.
2002: Humphries Martin J
Insights into integrin-ligand binding and activation from the first crystal structure.
Arthritis research 2002;4 Suppl 3():S69-78.
2001: Humphries M J; Mould A P
Structure. An anthropomorphic integrin.
Science (New York, N.Y.) 2001;294(5541):316-7.
2001: Coe A P; Askari J A; Kline A D; Robinson M K; Kirby H; Stephens P E; Humphries M J
Generation of a minimal alpha5beta1 integrin-Fc fragment.
The Journal of biological chemistry 2001;276(38):35854-66.
2001: Hicks M S; O'Leary V; Wilkin M; Bee S E; Humphries M J; Baron M
DrhoGEF3 encodes a new Drosophila DH domain protein that exhibits a highly dynamic embryonic expression pattern.
Development genes and evolution 2001;211(5):263-7.
2001: Mostafavi-Pour Z; Askari J A; Whittard J D; Humphries M J
Identification of a novel heparin-binding site in the alternatively spliced IIICS region of fibronectin: roles of integrins and proteoglycans in cell adhesion to fibronectin splice variants.
Matrix biology : journal of the International Society for Matrix Biology 2001;20(1):63-73.
2000: Tuckwell D S; Smith L; Korda M; Askari J A; Santoso S; Barnes M J; Farndale R W; Humphries M J
Monoclonal antibodies identify residues 199-216 of the integrin alpha2 vWFA domain as a functionally important region within alpha2beta1.
The Biochemical journal 2000;350 Pt 2():485-93.
2000: Mould A P; Askari J A; Humphries M J
Molecular basis of ligand recognition by integrin alpha 5beta 1. I. Specificity of ligand binding is determined by amino acid sequences in the second and third NH2-terminal repeats of the alpha subunit.
The Journal of biological chemistry 2000;275(27):20324-36.
2000: Humphries J D; Askari J A; Zhang X P; Takada Y; Humphries M J; Mould A P
Molecular basis of ligand recognition by integrin alpha5beta 1. II. Specificity of arg-gly-Asp binding is determined by Trp157 OF THE alpha subunit.
The Journal of biological chemistry 2000;275(27):20337-45.
2000: Clark K; Newham P; Burrows L; Askari J A; Humphries M J
Production of recombinant soluble human integrin alpha4beta1.
FEBS letters 2000;471(2-3):182-6.
2000: Humphries M J
Integrin cell adhesion receptors and the concept of agonism.
Trends in pharmacological sciences 2000;21(1):29-32.
2000: Humphries M J
Integrin structure.
Biochemical Society transactions 2000;28(4):311-39.
1999: Burrows L; Clark K; Mould A P; Humphries M J
Fine mapping of inhibitory anti-alpha5 monoclonal antibody epitopes that differentially affect integrin-ligand binding.
The Biochemical journal 1999;344 Pt 2():527-33.
1999: Curley G P; Blum H; Humphries M J
Integrin antagonists.
Cellular and molecular life sciences : CMLS 1999;56(5-6):427-41.
1999: Ng T T; Collins I E; Kanner S B; Humphries M J; Amft N; Wickremasinghe R G; D'Cruz D; Nye K E; Morrow W J
Integrin signalling defects in T-lymphocytes in systemic lupus erythematosus.
Lupus 1999;8(1):39-51.
1998: Mould A P; Burrows L; Humphries M J
Identification of amino acid residues that form part of the ligand-binding pocket of integrin alpha5 beta1.
The Journal of biological chemistry 1998;273(40):25664-72.
1998: Fernandez C; Clark K; Burrows L; Schofield N R; Humphries M J
Regulation of the extracellular ligand binding activity of integrins.
Frontiers in bioscience : a journal and virtual library 1998;3():d684-700.
1998: Newham P; Craig S E; Clark K; Mould A P; Humphries M J
Analysis of ligand-induced and ligand-attenuated epitopes on the leukocyte integrin alpha4beta1: VCAM-1, mucosal addressin cell adhesion molecule-1, and fibronectin induce distinct conformational changes.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(9):4508-17.
1998: Mould A P; Garratt A N; Puzon-McLaughlin W; Takada Y; Humphries M J
Regulation of integrin function: evidence that bivalent-cation-induced conformational changes lead to the unmasking of ligand-binding sites within integrin alpha5 beta1.
The Biochemical journal 1998;331 ( Pt 3)():821-8.
1998: Messent A J; Tuckwell D S; Knäuper V; Humphries M J; Murphy G; Gavrilovic J
Effects of collagenase-cleavage of type I collagen on alpha2beta1 integrin-mediated cell adhesion.
Journal of cell science 1998;111 ( Pt 8)():1127-35.
1998: Humphries M J; Newham P
The structure of cell-adhesion molecules.
Trends in cell biology 1998;8(2):78-83.
1998: Green L J; Mould A P; Humphries M J
The integrin beta subunit.
The international journal of biochemistry & cell biology 1998;30(2):179-84.
1997: Tselepis V H; Green L J; Humphries M J
An RGD to LDV motif conversion within the disintegrin kistrin generates an integrin antagonist that retains potency but exhibits altered receptor specificity. Evidence for a functional equivalence of acidic integrin-binding motifs.
The Journal of biological chemistry 1997;272(34):21341-8.
1997: Newham P; Craig S E; Seddon G N; Schofield N R; Rees A; Edwards R M; Jones E Y; Humphries M J
Alpha4 integrin binding interfaces on VCAM-1 and MAdCAM-1. Integrin binding footprints identify accessory binding sites that play a role in integrin specificity.
The Journal of biological chemistry 1997;272(31):19429-40.
1997: Mould A P; Askari J A; Aota S i; Yamada K M; Irie A; Takada Y; Mardon H J; Humphries M J
Defining the topology of integrin alpha5beta1-fibronectin interactions using inhibitory anti-alpha5 and anti-beta1 monoclonal antibodies. Evidence that the synergy sequence of fibronectin is recognized by the amino-terminal repeats of the alpha5 subunit.
The Journal of biological chemistry 1997;272(28):17283-92.
1997: Davies D; Tuckwell D S; Calderwood D A; Weston S A; Takigawa M; Humphries M J
Molecular characterisation of integrin-procollagen C-propeptide interactions.
European journal of biochemistry / FEBS 1997;246(2):274-82.
1997: Tuckwell D S; Xu Y; Newham P; Humphries M J; Volanakis J E
Surface loops adjacent to the cation-binding site of the complement factor B von Willebrand factor type A module determine C3b binding specificity.
Biochemistry 1997;36(22):6605-13.
1997: Ng T T; Kanner S B; Humphries M J; Wickremasinghe R G; Nye K E; Anderson J; Morrow W J
Dysfunctional focal adhesion kinase (pp125FAK) expression in HIV-infected donor T-cells.
Biochemical Society transactions 1997;25(2):219S.
1997: Calderwood D A; Tuckwell D S; Eble J; Kühn K; Humphries M J
The integrin alpha1 A-domain is a ligand binding site for collagens and laminin.
The Journal of biological chemistry 1997;272(19):12311-7.
1997: Ng T T; Kanner S B; Humphries M J; Wickremasinghe R G; Nye K E; Anderson J; Khoo S H; Morrow W J
The integrin-triggered rescue of T lymphocyte apoptosis is blocked in HIV-1-infected individuals.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(6):2984-99.
1997: Tuckwell D S; Humphries M J
A structure prediction for the ligand-binding region of the integrin beta subunit: evidence for the presence of a von Willebrand factor A domain.
FEBS letters 1997;400(3):297-303.
1996: Tuckwell D S; Reid K B; Barnes M J; Humphries M J
The A-domain of integrin alpha 2 binds specifically to a range of collagens but is not a general receptor for the collagenous motif.
European journal of biochemistry / FEBS 1996;241(3):732-9.
1996: Mould A P; Akiyama S K; Humphries M J
The inhibitory anti-beta1 integrin monoclonal antibody 13 recognizes an epitope that is attenuated by ligand occupancy. Evidence for allosteric inhibition of integrin function.
The Journal of biological chemistry 1996;271(34):20365-74.
1996: Newham P; Humphries M J
Integrin adhesion receptors: structure, function and implications for biomedicine.
Molecular medicine today 1996;2(7):304-13.
1995: Tuckwell D S; Humphries M J; Brass A
Protein secondary structure prediction by the analysis of variation and conservation in multiple alignments.
Computer applications in the biosciences : CABIOS 1995;11(6):627-32.
1995: Davies D; Tuckwell D S; Watson R B; Weston S A; Humphries M J
Regulation of extracellular matrix deposition by the C-propeptide domain of fibrillar collagens.
Biochemical Society transactions 1995;23(4):516S.
1995: Newham P; Humphries M J
Identification of a key structural element in VCAM-1.
Biochemical Society transactions 1995;23(4):512S.
1995: Green L J; Brierley V H; Humphries M J
Inhibition of integrin-ligand binding by recombinant kistrins.
Biochemical Society transactions 1995;23(4):505S.
1995: Calderwood D A; Tuckwell D S; Humphries M J
Specificity of integrin I-domain-ligand binding.
Biochemical Society transactions 1995;23(4):504S.
1995: Mould A P; Akiyama S K; Humphries M J
Regulation of integrin alpha 5 beta 1-fibronectin interactions by divalent cations. Evidence for distinct classes of binding sites for Mn2+, Mg2+, and Ca2+.
The Journal of biological chemistry 1995;270(44):26270-7.
1995: Mould A P; Garratt A N; Askari J A; Akiyama S K; Humphries M J
Regulation of integrin alpha 5 beta 1 function by anti-integrin antibodies and divalent cations.
Biochemical Society transactions 1995;23(3):395S.
1995: Tuckwell D; Calderwood D A; Green L J; Humphries M J
Integrin alpha 2 I-domain is a binding site for collagens.
Journal of cell science 1995;108 ( Pt 4)():1629-37.
1995: Mould A P; Garratt A N; Askari J A; Akiyama S K; Humphries M J
Identification of a novel anti-integrin monoclonal antibody that recognises a ligand-induced binding site epitope on the beta 1 subunit.
FEBS letters 1995;363(1-2):118-22.
1995: Weston S A; Crossett B; Tuckwell D S; Humphries M J
Effect of beta-mercaptoethanol on the detection of biotinylated proteins.
Analytical biochemistry 1995;225(1):28-33.
1995: Garratt A N; Humphries M J
Recent insights into ligand binding, activation and signalling by integrin adhesion receptors.
Acta anatomica 1995;154(1):34-45.
1995: Humphries M J; Sheridan J; Mould A P; Newham P
Mechanisms of VCAM-1 and fibronectin binding to integrin alpha 4 beta 1: implications for integrin function and rational drug design.
Ciba Foundation symposium 1995;189():177-91; discussion 191-9.
1994: Dudgeon T J; Bottomley M J; Driscoll P C; Humphries M J; Mould A P; Wingfield G I; Clements J M
Expression and characterisation of a very-late antigen-4 (alpha 4 beta 1) integrin-binding fragment of vascular cell-adhesion molecule-1.
European journal of biochemistry / FEBS 1994;226(2):517-23.
1994: Mould A P; Askari J A; Craig S E; Garratt A N; Clements J; Humphries M J
Integrin alpha 4 beta 1-mediated melanoma cell adhesion and migration on vascular cell adhesion molecule-1 (VCAM-1) and the alternatively spliced IIICS region of fibronectin.
The Journal of biological chemistry 1994;269(44):27224-30.
1994: Tuckwell D S; Humphries M J; Brass A
A secondary structure model of the integrin alpha subunit N-terminal domain based on analysis of multiple alignments.
Cell adhesion and communication 1994;2(5):385-402.
1994: Clements J M; Newham P; Shepherd M; Gilbert R; Dudgeon T J; Needham L A; Edwards R M; Berry L; Brass A; Humphries M J
Identification of a key integrin-binding sequence in VCAM-1 homologous to the LDV active site in fibronectin.
Journal of cell science 1994;107 ( Pt 8)():2127-35.
1994: Weston S A; Hulmes D J; Mould A P; Watson R B; Humphries M J
Identification of integrin alpha 2 beta 1 as cell surface receptor for the carboxyl-terminal propeptide of type I procollagen.
The Journal of biological chemistry 1994;269(33):20982-6.
1994: Humphries M J
Mechanisms of ligand binding by integrins.
Biochemical Society transactions 1994;22(2):275-82.
1994: Tuckwell D S; Ayad S; Grant M E; Takigawa M; Humphries M J
Conformation dependence of integrin-type II collagen binding. Inability of collagen peptides to support alpha 2 beta 1 binding, and mediation of adhesion to denatured collagen by a novel alpha 5 beta 1-fibronectin bridge.
Journal of cell science 1994;107 ( Pt 4)():993-1005.
1994: Makarem R; Newham P; Askari J A; Green L J; Clements J; Edwards M; Humphries M J; Mould A P
Competitive binding of vascular cell adhesion molecule-1 and the HepII/IIICS domain of fibronectin to the integrin alpha 4 beta 1.
The Journal of biological chemistry 1994;269(6):4005-11.
1993: Newham P; Tuckwell D S; Brass A; Humphries M J
Mechanism of integrin alpha 4 beta 1-VCAM-1 interaction.
Biochemical Society transactions 1993;21(4):339S.
1993: Tuckwell D S; Humphries M J
Molecular and cellular biology of integrins.
Critical reviews in oncology/hematology 1993;15(2):149-71.
1993: May M J; Entwistle G; Humphries M J; Ager A
VCAM-1 is a CS1 peptide-inhibitable adhesion molecule expressed by lymph node high endothelium.
Journal of cell science 1993;106 ( Pt 1)():109-19.
1993: Humphries M J; Mould A P; Tuckwell D S
Dynamic aspects of adhesion receptor function--integrins both twist and shout.
BioEssays : news and reviews in molecular, cellular and developmental biology 1993;15(6):391-7.
1993: Tuckwell D S; Weston S A; Humphries M J
Integrins: a review of their structure and mechanisms of ligand binding.
Symposia of the Society for Experimental Biology 1993;47():107-36.
1992: Tuckwell D S; Brass A; Humphries M J
Homology modelling of integrin EF-hands. Evidence for widespread use of a conserved cation-binding site.
The Biochemical journal 1992;285 ( Pt 1)():325-31.
1991: Mould A P; Humphries M J
Identification of a novel recognition sequence for the integrin alpha 4 beta 1 in the COOH-terminal heparin-binding domain of fibronectin.
The EMBO journal 1991;10(13):4089-95.
1991: Grant M E; Humphries M J
The extracellular matrix in health and disease: preface.
Biochemical Society transactions 1991;19(4):803-4.
1991: Tuckwell D S; Allen M D; Takigawa M; Humphries M J
Novel methods for the study of cell-collagen interactions.
Biochemical Society transactions 1991;19(4):370S.
1991: Mould A P; Askari J A; Akiyama S K; Yamada K M; Humphries M J
An assessment of the efficacy of anti-integrin alpha subunit monoclonal antibody production using affinity purified beta 1-integrin dimers as immunogen.
Biochemical Society transactions 1991;19(4):361S.
1991: Makarem R; Humphries M J
LDV: a novel cell adhesion motif recognized by the integrin alpha 4 beta 1.
Biochemical Society transactions 1991;19(4):380S.
1991: Mould A P; Komoriya A; Yamada K M; Humphries M J
The CS5 peptide is a second site in the IIICS region of fibronectin recognized by the integrin alpha 4 beta 1. Inhibition of alpha 4 beta 1 function by RGD peptide homologues.
The Journal of biological chemistry 1991;266(6):3579-85.
1990: Humphries M J
The molecular basis and specificity of integrin-ligand interactions.
Journal of cell science 1990;97 ( Pt 4)():585-92.
1990: Mould A P; Wheldon L A; Komoriya A; Wayner E A; Yamada K M; Humphries M J
Affinity chromatographic isolation of the melanoma adhesion receptor for the IIICS region of fibronectin and its identification as the integrin alpha 4 beta 1.
The Journal of biological chemistry 1990;265(7):4020-4.

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