Keith Humphries

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TOP 3
Heuser Michael; Sly Laura M; Argiropoulos Bob; Kuchenbauer Florian; Lai Courteney; Weng Andrew; Leung Malina; Lin Grace; Brookes Christy; Fung Stephen; Valk Peter J; Delwel Ruud; Löwenberg Bob; Krystal Gerald; Humphries R Keith
Modeling the functional heterogeneity of leukemia stem cells: role of STAT5 in leukemia stem cell self-renewal.
Heuser Michael; Kuchenbauer Florian; Argiropoulos Bob; Sekulovic Sanja; Leung Malina; Stasiak Marcin; Ganser Arnold; Humphries R Keith
Priming reloaded?
Heuser Michael; Yap Damian B; Leung Malina; de Algara Teresa Ruiz; Tafech Alaeddin; McKinney Steven; Dixon John; Thresher Rosemary; Colledge Bill; Carlton Mark; Humphries R Keith; Aparicio Samuel A
Loss of MLL5 results in pleiotropic hematopoietic defects, reduced neutrophil immune function, and extreme sensitivity to DNA demethylation.

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All Publications

2009: Heuser Michael; Sly Laura M; Argiropoulos Bob; Kuchenbauer Florian; Lai Courteney; Weng Andrew; Leung Malina; Lin Grace; Brookes Christy; Fung Stephen; Valk Peter J; Delwel Ruud; Löwenberg Bob; Krystal Gerald; Humphries R Keith
Modeling the functional heterogeneity of leukemia stem cells: role of STAT5 in leukemia stem cell self-renewal.
Blood 2009;114(19):3983-93.
2009: Heuser Michael; Kuchenbauer Florian; Argiropoulos Bob; Sekulovic Sanja; Leung Malina; Stasiak Marcin; Ganser Arnold; Humphries R Keith
Priming reloaded?
Blood 2009;114(4):925-6; author reply 926-7.
2009: Heuser Michael; Yap Damian B; Leung Malina; de Algara Teresa Ruiz; Tafech Alaeddin; McKinney Steven; Dixon John; Thresher Rosemary; Colledge Bill; Carlton Mark; Humphries R Keith; Aparicio Samuel A
Loss of MLL5 results in pleiotropic hematopoietic defects, reduced neutrophil immune function, and extreme sensitivity to DNA demethylation.
Blood 2009;113(7):1432-43.
2008: Kuchenbauer Florian; Morin Ryan D; Argiropoulos Bob; Petriv Oleh I; Griffith Malachi; Heuser Michael; Yung Eric; Piper Jessica; Delaney Allen; Prabhu Anna-Liisa; Zhao Yongjun; McDonald Helen; Zeng Thomas; Hirst Martin; Hansen Carl L; Marra Marco A; Humphries R Keith
In-depth characterization of the microRNA transcriptome in a leukemia progression model.
Genome research 2008;18(11):1787-97.
2008: Hirose K; Abramovich C; Argiropoulos B; Humphries R K
Leukemogenic properties of NUP98-PMX1 are linked to NUP98 and homeodomain sequence functions but not to binding properties of PMX1 to serum response factor.
Oncogene 2008;27(46):6056-67.
2008: Rouhi Arefeh; Mager Dixie L; Humphries R Keith; Kuchenbauer Florian
MiRNAs, epigenetics, and cancer.
Mammalian genome : official journal of the International Mammalian Genome Society 2008;19(7-8):517-25.
2008: Argiropoulos Bob; Palmqvist Lars; Yung Eric; Kuchenbauer Florian; Heuser Michael; Sly Laura M; Wan Adrian; Krystal Gerald; Humphries R Keith
Linkage of Meis1 leukemogenic activity to multiple downstream effectors including Trib2 and Ccl3.
Experimental hematology 2008;36(7):845-59.
2008: Faubert A; Chagraoui J; Mayotte N; Fréchette M; Iscove N N; Humphries R K; Sauvageau G
Complementary and independent function for Hoxb4 and Bmi1 in HSC activity.
Cold Spring Harbor symposia on quantitative biology 2008;73():555-64.
2007: Argiropoulos Bob; Yung Eric; Humphries R Keith
Unraveling the crucial roles of Meis1 in leukemogenesis and normal hematopoiesis.
Genes & development 2007;21(22):2845-9.
2007: Argiropoulos B; Humphries R K
Hox genes in hematopoiesis and leukemogenesis.
Oncogene 2007;26(47):6766-76.
2007: Heuser Michael; Argiropoulos Bob; Kuchenbauer Florian; Yung Eric; Piper Jessica; Fung Stephen; Schlenk Richard F; Dohner Konstanze; Hinrichsen Tanja; Rudolph Cornelia; Schambach Axel; Baum Christopher; Schlegelberger Brigitte; Dohner Hartmut; Ganser Arnold; Humphries R Keith
MN1 overexpression induces acute myeloid leukemia in mice and predicts ATRA resistance in patients with AML.
Blood 2007;110(5):1639-47.
2007: Lu Min; Glover Clive H; Tien Amy H; Humphries R Keith; Piret James M; Helgason Cheryl D
Involvement of tyrosine kinase signaling in maintaining murine embryonic stem cell functionality.
Experimental hematology 2007;35(8):1293-302.
2007: Ohta Hideaki; Sekulovic Sanja; Bakovic Silvia; Eaves Connie J; Pineault Nicolas; Gasparetto Maura; Smith Clayton; Sauvageau Guy; Humphries R Keith
Near-maximal expansions of hematopoietic stem cells in culture using NUP98-HOX fusions.
Experimental hematology 2007;35(5):817-30.
2007: Cellot Sonia; Krosl Jana; Chagraoui Jalila; Meloche Sylvain; Humphries R Keith; Sauvageau Guy
Sustained in vitro trigger of self-renewal divisions in Hoxb4hiPbx1(10) hematopoietic stem cells.
Experimental hematology 2007;35(5):802-16.
2007: Palmqvist Lars; Pineault Nicolas; Wasslavik Carina; Humphries R Keith
Candidate genes for expansion and transformation of hematopoietic stem cells by NUP98-HOX fusion genes.
PloS one 2007;2(1):e768.
2006: Deshpande Aniruddha J; Cusan Monica; Rawat Vijay P S; Reuter Hendrik; Krause Alexandre; Pott Christiane; Quintanilla-Martinez Leticia; Kakadia Purvi; Kuchenbauer Florian; Ahmed Farid; Delabesse Eric; Hahn Meinhard; Lichter Peter; Kneba Michael; Hiddemann Wolfgang; Macintyre Elizabeth; Mecucci Cristina; Ludwig Wolf-Dieter; Humphries R Keith; Bohlander Stefan K; Feuring-Buske Michaela; Buske Christian
Acute myeloid leukemia is propagated by a leukemic stem cell with lymphoid characteristics in a mouse model of CALM/AF10-positive leukemia.
Cancer cell 2006;10(5):363-74.
2006: Gurevich Rhonna M; Rosten Patty M; Schwieger Maike; Stocking Carol; Humphries R Keith
Retroviral integration site analysis identifies ICSBP as a collaborating tumor suppressor gene in NUP98-TOP1-induced leukemia.
Experimental hematology 2006;34(9):1192-201.
2006: Palmqvist Lars; Argiropoulos Bob; Pineault Nicolas; Abramovich Carolina; Sly Laura M; Krystal Gerald; Wan Adrian; Humphries R Keith
The Flt3 receptor tyrosine kinase collaborates with NUP98-HOX fusions in acute myeloid leukemia.
Blood 2006;108(3):1030-6.
2006: Fisher Cynthia L; Randazzo Filippo; Humphries R Keith; Brock Hugh W
Characterization of Asxl1, a murine homolog of Additional sex combs, and analysis of the Asx-like gene family.
Gene 2006;369():109-18.
2005: Lawrence H Jeffrey; Christensen Julie; Fong Stephen; Hu Yu-Long; Weissman Irving; Sauvageau Guy; Humphries R Keith; Largman Corey
Loss of expression of the Hoxa-9 homeobox gene impairs the proliferation and repopulating ability of hematopoietic stem cells.
Blood 2005;106(12):3988-94.
2005: Schessl Christina; Rawat Vijay P S; Cusan Monica; Deshpande Aniruddha; Kohl Tobias M; Rosten Patricia M; Spiekermann Karsten; Humphries R Keith; Schnittger Susanne; Kern Wolfgang; Hiddemann Wolfgang; Quintanilla-Martinez Leticia; Bohlander Stefan K; Feuring-Buske Michaela; Buske Christian
The AML1-ETO fusion gene and the FLT3 length mutation collaborate in inducing acute leukemia in mice.
The Journal of clinical investigation 2005;115(8):2159-68.
2005: Abramovich Carolina; Pineault Nicolas; Ohta Hideaki; Humphries R Keith
Hox genes: from leukemia to hematopoietic stem cell expansion.
Annals of the New York Academy of Sciences 2005;1044():109-16.
2005: Abramovich Carolina; Humphries R Keith
Hox regulation of normal and leukemic hematopoietic stem cells.
Current opinion in hematology 2005;12(3):210-6.
2005: Palmqvist Lars; Glover Clive H; Hsu Lien; Lu Min; Bossen Bolette; Piret James M; Humphries R Keith; Helgason Cheryl D
Correlation of murine embryonic stem cell gene expression profiles with functional measures of pluripotency.
Stem cells (Dayton, Ohio) 2005;23(5):663-80.
2005: Ferrell Christina M; Dorsam Sheri T; Ohta Hideaki; Humphries R Keith; Derynck Mika Kakefuda; Haqq Chris; Largman Corey; Lawrence H Jeffrey
Activation of stem-cell specific genes by HOXA9 and HOXA10 homeodomain proteins in CD34+ human cord blood cells.
Stem cells (Dayton, Ohio) 2005;23(5):644-55.
2005: Pineault N; Abramovich C; Humphries R K
Transplantable cell lines generated with NUP98-Hox fusion genes undergo leukemic progression by Meis1 independent of its binding to DNA.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2005;19(4):636-43.
2004: Imren Suzan; Fabry Mary E; Westerman Karen A; Pawliuk Robert; Tang Patrick; Rosten Patricia M; Nagel Ronald L; Leboulch Philippe; Eaves Connie J; Humphries R Keith
High-level beta-globin expression and preferred intragenic integration after lentiviral transduction of human cord blood stem cells.
The Journal of clinical investigation 2004;114(7):953-62.
2004: Sauvageau Guy; Iscove Norman N; Humphries R Keith
In vitro and in vivo expansion of hematopoietic stem cells.
Oncogene 2004;23(43):7223-32.
2004: Oh Il-Hoan; Fabry Mary E; Humphries R Keith; Pawliuk Robert; Leboulch Philippe; Hoffman Ronald; Nagel Ronald L; Eaves Connie
Expression of an anti-sickling beta-globin in human erythroblasts derived from retrovirally transduced primitive normal and sickle cell disease hematopoietic cells.
Experimental hematology 2004;32(5):461-9.
2004: Pineault Nicolas; Abramovich Carolina; Ohta Hideaki; Humphries R Keith
Differential and common leukemogenic potentials of multiple NUP98-Hox fusion proteins alone or with Meis1.
Molecular and cellular biology 2004;24(5):1907-17.
2004: Nicolini F E; Cashman J D; Hogge D E; Humphries R K; Eaves C J
NOD/SCID mice engineered to express human IL-3, GM-CSF and Steel factor constitutively mobilize engrafted human progenitors and compromise human stem cell regeneration.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2004;18(2):341-7.
2004: Rawat Vijay P S; Cusan Monica; Deshpande Aniruddha; Hiddemann Wolfgang; Quintanilla-Martinez Leticia; Humphries R Keith; Bohlander Stefan K; Feuring-Buske Michaela; Buske Christian
Ectopic expression of the homeobox gene Cdx2 is the transforming event in a mouse model of t(12;13)(p13;q12) acute myeloid leukemia.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(3):817-22.
2003: Krosl Jana; Austin Pamela; Beslu Nathalie; Kroon Evert; Humphries R Keith; Sauvageau Guy
In vitro expansion of hematopoietic stem cells by recombinant TAT-HOXB4 protein.
Nature medicine 2003;9(11):1428-32.
2003: Helgason Cheryl D; Antonchuk Jennifer; Bodner Caroline; Humphries R Keith
Homeostasis and regeneration of the hematopoietic stem cell pool are altered in SHIP-deficient mice.
Blood 2003;102(10):3541-7.
2003: Larrivée Bruno; Lane David R; Pollet Ingrid; Olive Peggy L; Humphries R Keith; Karsan Aly
Vascular endothelial growth factor receptor-2 induces survival of hematopoietic progenitor cells.
The Journal of biological chemistry 2003;278(24):22006-13.
2003: Pineault Nicolas; Buske Christian; Feuring-Buske Michaela; Abramovich Carolina; Rosten Patty; Hogge Donna E; Aplan Peter D; Humphries R Keith
Induction of acute myeloid leukemia in mice by the human leukemia-specific fusion gene NUP98-HOXD13 in concert with Meis1.
Blood 2003;101(11):4529-38.
2003: Krosl Jana; Beslu Nathalie; Mayotte Nadine; Humphries R Keith; Sauvageau Guy
The competitive nature of HOXB4-transduced HSC is limited by PBX1: the generation of ultra-competitive stem cells retaining full differentiation potential.
Immunity 2003;18(4):561-71.
2003: Feuring-Buske M; Gerhard B; Cashman J; Humphries R K; Eaves C J; Hogge D E
Improved engraftment of human acute myeloid leukemia progenitor cells in beta 2-microglobulin-deficient NOD/SCID mice and in NOD/SCID mice transgenic for human growth factors.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2003;17(4):760-3.
2002: Imren Suzan; Payen Emmanuel; Westerman Karen A; Pawliuk Robert; Fabry Mary E; Eaves Connie J; Cavilla Benjamin; Wadsworth Louis D; Beuzard Yves; Bouhassira Eric E; Russell Robert; London Irving M; Nagel Ronald L; Leboulch Philippe; Humphries R Keith
Permanent and panerythroid correction of murine beta thalassemia by multiple lentiviral integration in hematopoietic stem cells.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(22):14380-5.
2002: Abramovich Carolina; Chavez Elizabeth A; Lansdorp Peter M; Humphries R Keith
Functional characterization of multiple domains involved in the subcellular localization of the hematopoietic Pbx interacting protein (HPIP).
Oncogene 2002;21(44):6766-71.
2002: Miller Cindy L; Imren Suzan; Antonchuk Jennifer; Kalberer Christian; Fabry Mary E; Nagel Ronald L; Humphries R Keith; Eaves Connie J
Feasibility of using autologous transplantation to evaluate hematopoietic stem cell-based gene therapy strategies in transgenic mouse models of human disease.
Molecular therapy : the journal of the American Society of Gene Therapy 2002;6(3):422-8.
2002: Takeshita Sunao; Namba Noriyuki; Zhao Jenny J; Jiang Yebin; Genant Harry K; Silva Matthew J; Brodt Michael D; Helgason Cheryl D; Kalesnikoff Janet; Rauh Michael J; Humphries R Keith; Krystal Gerald; Teitelbaum Steven L; Ross F Patrick
SHIP-deficient mice are severely osteoporotic due to increased numbers of hyper-resorptive osteoclasts.
Nature medicine 2002;8(9):943-9.
2002: Nicolini Franck E; Imren Suzan; Oh Il-Hoan; Humphries R Keith; Leboulch Philippe; Fabry Mary E; Nagel Ronald L; Eaves Connie J
Expression of a human beta-globin transgene in erythroid cells derived from retrovirally transduced transplantable human fetal liver and cord blood cells.
Blood 2002;100(4):1257-64.
2002: Buske Christian; Feuring-Buske Michaela; Abramovich Carolina; Spiekermann Karsten; Eaves Connie J; Coulombel Laure; Sauvageau Guy; Hogge Donna E; Humphries R Keith
Deregulated expression of HOXB4 enhances the primitive growth activity of human hematopoietic cells.
Blood 2002;100(3):862-8.
2002: Antonchuk Jennifer; Sauvageau Guy; Humphries R Keith
HOXB4-induced expansion of adult hematopoietic stem cells ex vivo.
Cell 2002;109(1):39-45.
2002: Pineault Nicolas; Helgason Cheryl D; Lawrence H Jeffrey; Humphries R Keith
Differential expression of Hox, Meis1, and Pbx1 genes in primitive cells throughout murine hematopoietic ontogeny.
Experimental hematology 2002;30(1):49-57.
2001: Pawliuk R; Westerman K A; Fabry M E; Payen E; Tighe R; Bouhassira E E; Acharya S A; Ellis J; London I M; Eaves C J; Humphries R K; Beuzard Y; Nagel R L; Leboulch P
Correction of sickle cell disease in transgenic mouse models by gene therapy.
Science (New York, N.Y.) 2001;294(5550):2368-71.
2001: Antonchuk J; Sauvageau G; Humphries R K
HOXB4 overexpression mediates very rapid stem cell regeneration and competitive hematopoietic repopulation.
Experimental hematology 2001;29(9):1125-34.
2001: Rufer N; Migliaccio M; Antonchuk J; Humphries R K; Roosnek E; Lansdorp P M
Transfer of the human telomerase reverse transcriptase (TERT) gene into T lymphocytes results in extension of replicative potential.
Blood 2001;98(3):597-603.
2001: Buske C; Feuring-Buske M; Antonchuk J; Rosten P; Hogge D E; Eaves C J; Humphries R K
Overexpression of HOXA10 perturbs human lymphomyelopoiesis in vitro and in vivo.
Blood 2001;97(8):2286-92.
2000: Hennemann B; Oh I H; Chuo J Y; Kalberer C P; Schley P D; Rose-John S; Humphries R K; Eaves C J
Efficient retrovirus-mediated gene transfer to transplantable human bone marrow cells in the absence of fibronectin.
Blood 2000;96(7):2432-9.
2000: Abramovich C; Shen W F; Pineault N; Imren S; Montpetit B; Largman C; Humphries R K
Functional cloning and characterization of a novel nonhomeodomain protein that inhibits the binding of PBX1-HOX complexes to DNA.
The Journal of biological chemistry 2000;275(34):26172-7.
2000: Buske C; Humphries R K
Homeobox genes in leukemogenesis.
International journal of hematology 2000;71(4):301-8.
2000: Kalberer C P; Pawliuk R; Imren S; Bachelot T; Takekoshi K J; Fabry M; Eaves C J; London I M; Humphries R K; Leboulch P
Preselection of retrovirally transduced bone marrow avoids subsequent stem cell gene silencing and age-dependent extinction of expression of human beta-globin in engrafted mice.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(10):5411-5.
2000: Helgason C D; Kalberer C P; Damen J E; Chappel S M; Pineault N; Krystal G; Humphries R K
A dual role for Src homology 2 domain-containing inositol-5-phosphatase (SHIP) in immunity: aberrant development and enhanced function of b lymphocytes in ship -/- mice.
The Journal of experimental medicine 2000;191(5):781-94.
2000: Metzler M; Helgason C D; Dragatsis I; Zhang T; Gan L; Pineault N; Zeitlin S O; Humphries R K; Hayden M R
Huntingtin is required for normal hematopoiesis.
Human molecular genetics 2000;9(3):387-94.
2000: Hennemann B; Chuo J Y; Schley P D; Lambie K; Humphries R K; Eaves C J
High-efficiency retroviral transduction of mammalian cells on positively charged surfaces.
Human gene therapy 2000;11(1):43-51.
1999: Ailles L E; Humphries R K; Thomas T E; Hogge D E
Retroviral marking of acute myelogenous leukemia progenitors that initiate long-term culture and growth in immunodeficient mice.
Experimental hematology 1999;27(11):1609-20.
1999: Krystal G; Damen J E; Helgason C D; Huber M; Hughes M R; Kalesnikoff J; Lam V; Rosten P; Ware M D; Yew S; Humphries R K
SHIPs ahoy.
The international journal of biochemistry & cell biology 1999;31(10):1007-10.
1999: Thorsteinsdottir U; Sauvageau G; Humphries R K
Enhanced in vivo regenerative potential of HOXB4-transduced hematopoietic stem cells with regulation of their pool size.
Blood 1999;94(8):2605-12.
1999: Kawagoe H; Humphries R K; Blair A; Sutherland H J; Hogge D E
Expression of HOX genes, HOX cofactors, and MLL in phenotypically and functionally defined subpopulations of leukemic and normal human hematopoietic cells.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1999;13(5):687-98.
1999: Hennemann B; Conneally E; Pawliuk R; Leboulch P; Rose-John S; Reid D; Chuo J Y; Humphries R K; Eaves C J
Optimization of retroviral-mediated gene transfer to human NOD/SCID mouse repopulating cord blood cells through a systematic analysis of protocol variables.
Experimental hematology 1999;27(5):817-25.
1999: Doheny J G; Jervis E J; Guarna M M; Humphries R K; Warren R A; Kilburn D G
Cellulose as an inert matrix for presenting cytokines to target cells: production and properties of a stem cell factor-cellulose-binding domain fusion protein.
The Biochemical journal 1999;339 ( Pt 2)():429-34.
1999: Huber M; Helgason C D; Damen J E; Scheid M P; Duronio V; Lam V; Humphries R K; Krystal G
The role of the SRC homology 2-containing inositol 5'-phosphatase in Fc epsilon R1-induced signaling.
Current topics in microbiology and immunology 1999;244():29-41.
1999: Huber M; Helgason C D; Damen J E; Scheid M; Duronio V; Liu L; Ware M D; Humphries R K; Krystal G
The role of SHIP in growth factor induced signalling.
Progress in biophysics and molecular biology 1999;71(3-4):423-34.
1998: Huber M; Helgason C D; Scheid M P; Duronio V; Humphries R K; Krystal G
Targeted disruption of SHIP leads to Steel factor-induced degranulation of mast cells.
The EMBO journal 1998;17(24):7311-9.
1998: Huber M; Helgason C D; Damen J E; Liu L; Humphries R K; Krystal G
The src homology 2-containing inositol phosphatase (SHIP) is the gatekeeper of mast cell degranulation.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(19):11330-5.
1998: Pawliuk R; Bachelot T; Raftopoulos H; Kalberer C; Humphries R K; Bank A; Leboulch P
Retroviral vectors aimed at the gene therapy of human beta-globin gene disorders.
Annals of the New York Academy of Sciences 1998;850():151-62.
1998: Helgason C D; Damen J E; Rosten P; Grewal R; Sorensen P; Chappel S M; Borowski A; Jirik F; Krystal G; Humphries R K
Targeted disruption of SHIP leads to hemopoietic perturbations, lung pathology, and a shortened life span.
Genes & development 1998;12(11):1610-20.
1998: Conneally E; Eaves C J; Humphries R K
Efficient retroviral-mediated gene transfer to human cord blood stem cells with in vivo repopulating potential.
Blood 1998;91(9):3487-93.
1997: Thorsteinsdottir U; Sauvageau G; Humphries R K
Hox homeobox genes as regulators of normal and leukemic hematopoiesis.
Hematology/oncology clinics of North America 1997;11(6):1221-37.
1997: Pawliuk R; Eaves C J; Humphries R K
Sustained high-level reconstitution of the hematopoietic system by preselected hematopoietic cells expressing a transduced cell-surface antigen.
Human gene therapy 1997;8(13):1595-604.
1997: Bardy P; Conneally E; Emerman J T; Lansdorp P M; Goss G; Humphries R K; Eaves C J
Isolation and analysis of different subpopulations of normal human breast epithelial cells after their infection with a retroviral vector encoding a cell surface marker.
Breast cancer research and treatment 1997;44(2):153-65.
1997: Damen J E; Liu L; Wakao H; Miyajima A; Rosten P; Jefferson A B; Majerus P W; Krosl J; Humphries R K; Krystal G
The role of erythropoietin receptor tyrosine phosphorylation in erythropoietin-induced proliferation.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1997;11 Suppl 3():423-5.
1997: Lawrence H J; Helgason C D; Sauvageau G; Fong S; Izon D J; Humphries R K; Largman C
Mice bearing a targeted interruption of the homeobox gene HOXA9 have defects in myeloid, erythroid, and lymphoid hematopoiesis.
Blood 1997;89(6):1922-30.
1997: Sauvageau G; Thorsteinsdottir U; Hough M R; Hugo P; Lawrence H J; Largman C; Humphries R K
Overexpression of HOXB3 in hematopoietic cells causes defective lymphoid development and progressive myeloproliferation.
Immunity 1997;6(1):13-22.
1997: Thorsteinsdottir U; Sauvageau G; Hough M R; Dragowska W; Lansdorp P M; Lawrence H J; Largman C; Humphries R K
Overexpression of HOXA10 in murine hematopoietic cells perturbs both myeloid and lymphoid differentiation and leads to acute myeloid leukemia.
Molecular and cellular biology 1997;17(1):495-505.
1996: Chappel M S; Hough M R; Mittel A; Takei F; Kay R; Humphries R K
Cross-linking the murine heat-stable antigen induces apoptosis in B cell precursors and suppresses the anti-CD40-induced proliferation of mature resting B lymphocytes.
The Journal of experimental medicine 1996;184(5):1639-49.
1996: Krosl J; Damen J E; Krystal G; Humphries R K
Interleukin-3 (IL-3) inhibits erythropoietin-induced differentiation in Ba/F3 cells via the IL-3 receptor alpha subunit.
The Journal of biological chemistry 1996;271(44):27432-7.
1996: Pawliuk R; Eaves C; Humphries R K
Evidence of both ontogeny and transplant dose-regulated expansion of hematopoietic stem cells in vivo.
Blood 1996;88(8):2852-8.
1996: Ware M D; Rosten P; Damen J E; Liu L; Humphries R K; Krystal G
Cloning and characterization of human SHIP, the 145-kD inositol 5-phosphatase that associates with SHC after cytokine stimulation.
Blood 1996;88(8):2833-40.
1996: Lawrence H J; Sauvageau G; Humphries R K; Largman C
The role of HOX homeobox genes in normal and leukemic hematopoiesis.
Stem cells (Dayton, Ohio) 1996;14(3):281-91.
1996: Helgason C D; Sauvageau G; Lawrence H J; Largman C; Humphries R K
Overexpression of HOXB4 enhances the hematopoietic potential of embryonic stem cells differentiated in vitro.
Blood 1996;87(7):2740-9.
1996: Medin J A; Migita M; Pawliuk R; Jacobson S; Amiri M; Kluepfel-Stahl S; Brady R O; Humphries R K; Karlsson S
A bicistronic therapeutic retroviral vector enables sorting of transduced CD34+ cells and corrects the enzyme deficiency in cells from Gaucher patients.
Blood 1996;87(5):1754-62.
1996: Shen W F; Chang C P; Rozenfeld S; Sauvageau G; Humphries R K; Lu M; Lawrence H J; Cleary M L; Largman C
Hox homeodomain proteins exhibit selective complex stabilities with Pbx and DNA.
Nucleic acids research 1996;24(5):898-906.
1996: Damen J E; Liu L; Rosten P; Humphries R K; Jefferson A B; Majerus P W; Krystal G
The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(4):1689-93.
1996: Conneally E; Bardy P; Eaves C J; Thomas T; Chappel S; Shpall E J; Humphries R K
Rapid and efficient selection of human hematopoietic cells expressing murine heat-stable antigen as an indicator of retroviral-mediated gene transfer.
Blood 1996;87(2):456-64.
1996: Hough M R; Chappel M S; Sauvageau G; Takei F; Kay R; Humphries R K
Reduction of early B lymphocyte precursors in transgenic mice overexpressing the murine heat-stable antigen.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(2):479-88.
1995: Migita M; Medin J A; Pawliuk R; Jacobson S; Nagle J W; Anderson S; Amiri M; Humphries R K; Karlsson S
Selection of transduced CD34+ progenitors and enzymatic correction of cells from Gaucher patients, with bicistronic vectors.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(26):12075-9.
1995: Damen J E; Wakao H; Miyajima A; Krosl J; Humphries R K; Cutler R L; Krystal G
Tyrosine 343 in the erythropoietin receptor positively regulates erythropoietin-induced cell proliferation and Stat5 activation.
The EMBO journal 1995;14(22):5557-68.
1995: Sauvageau G; Thorsteinsdottir U; Eaves C J; Lawrence H J; Largman C; Lansdorp P M; Humphries R K
Overexpression of HOXB4 in hematopoietic cells causes the selective expansion of more primitive populations in vitro and in vivo.
Genes & development 1995;9(14):1753-65.
1995: Lewis M E; Forsythe I J; Marth J D; Brunzell J D; Hayden M R; Humphries R K
Retroviral-mediated gene transfer and expression of human lipoprotein lipase in somatic cells.
Human gene therapy 1995;6(7):853-63.
1995: Krosl J; Damen J E; Krystal G; Humphries R K
Erythropoietin and interleukin-3 induce distinct events in erythropoietin receptor-expressing BA/F3 cells.
Blood 1995;85(1):50-6.
1994: Sauvageau G; Lansdorp P M; Eaves C J; Hogge D E; Dragowska W H; Reid D S; Largman C; Lawrence H J; Humphries R K
Differential expression of homeobox genes in functionally distinct CD34+ subpopulations of human bone marrow cells.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(25):12223-7.
1994: Pawliuk R; Kay R; Lansdorp P; Humphries R K
Selection of retrovirally transduced hematopoietic cells using CD24 as a marker of gene transfer.
Blood 1994;84(9):2868-77.
1994: Leboulch P; Huang G M; Humphries R K; Oh Y H; Eaves C J; Tuan D Y; London I M
Mutagenesis of retroviral vectors transducing human beta-globin gene and beta-globin locus control region derivatives results in stable transmission of an active transcriptional structure.
The EMBO journal 1994;13(13):3065-76.
1994: Hough M R; Rosten P M; Sexton T L; Kay R; Humphries R K
Mapping of CD24 and homologous sequences to multiple chromosomal loci.
Genomics 1994;22(1):154-61.
1994: Hogge D E; Sutherland H J; Cashman J D; Lansdorp P M; Humphries R K; Eaves C J
Cytokines acting early in human haematopoiesis.
Baillière's clinical haematology 1994;7(1):49-63.
1994: Hough M R; Takei F; Humphries R K; Kay R
Defective development of thymocytes overexpressing the costimulatory molecule, heat-stable antigen.
The Journal of experimental medicine 1994;179(1):177-84.
1994: Rebel V I; Dragowska W; Eaves C J; Humphries R K; Lansdorp P M
Amplification of Sca-1+ Lin- WGA+ cells in serum-free cultures containing steel factor, interleukin-6, and erythropoietin with maintenance of cells with long-term in vivo reconstituting potential.
Blood 1994;83(1):128-36.
1993: Fraser C C; Thacker J D; Hogge D E; Fatur-Saunders D; Takei F; Humphries R K
Alterations in lymphopoiesis after hematopoietic reconstitution with IL-7 virus-infected bone marrow.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(5):2409-18.
1992: Mui A L; Kay R J; Humphries R K; Krystal G
Ligand-induced phosphorylation of the murine interleukin 3 receptor signals its cleavage.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(22):10812-6.
1992: Turhan A G; Cashman J D; Eaves C J; Humphries R K; Eaves A C
Variable expression of features of normal and neoplastic stem cells in patients with thrombocytosis.
British journal of haematology 1992;82(1):50-7.
1992: Mui A L; Kay R J; Humphries R K; Krystal G
Purification of the murine interleukin 3 receptor.
The Journal of biological chemistry 1992;267(23):16523-30.
1992: Hughes P F; Thacker J D; Hogge D; Sutherland H J; Thomas T E; Lansdorp P M; Eaves C J; Humphries R K
Retroviral gene transfer to primitive normal and leukemic hematopoietic cells using clinically applicable procedures.
The Journal of clinical investigation 1992;89(6):1817-24.
1992: Fraser C C; Szilvassy S J; Eaves C J; Humphries R K
Proliferation of totipotent hematopoietic stem cells in vitro with retention of long-term competitive in vivo reconstituting ability.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(5):1968-72.
1992: Eaves C J; Sutherland H J; Udomsakdi C; Lansdorp P M; Szilvassy S J; Fraser C C; Humphries R K; Barnett M J; Phillips G L; Eaves A C
The human hematopoietic stem cell in vitro and in vivo.
Blood cells 1992;18(2):301-7.
1991: Otsuka T; Eaves C J; Humphries R K; Hogge D E; Eaves A C
Lack of evidence for abnormal autocrine or paracrine mechanisms underlying the uncontrolled proliferation of primitive chronic myeloid leukemia progenitor cells.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1991;5(10):861-8.
1991: Kay R; Rosten P M; Humphries R K
CD24, a signal transducer modulating B cell activation responses, is a very short peptide with a glycosyl phosphatidylinositol membrane anchor.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(4):1412-6.
1991: Turhan A G; Eaves C J; Humphries R K; Phillips G L; Eaves A C
Reversing clonality in leukemia.
Seminars in hematology 1991;28(3 Suppl 4):5-8.
1991: Eaves C J; Cashman J D; Kay R J; Dougherty G J; Otsuka T; Gaboury L A; Hogge D E; Lansdorp P M; Eaves A C; Humphries R K
Mechanisms that regulate the cell cycle status of very primitive hematopoietic cells in long-term human marrow cultures. II. Analysis of positive and negative regulators produced by stromal cells within the adherent layer.
Blood 1991;78(1):110-7.
1991: Eaves C J; Sutherland H J; Cashman J D; Otsuka T; Lansdorp P M; Humphries R K; Eaves A C; Hogge D E
Regulation of primitive human hematopoietic cells in long-term marrow culture.
Seminars in hematology 1991;28(2):126-31.
1991: Hogge D E; Cashman J D; Humphries R K; Eaves C J
Differential and synergistic effects of human granulocyte-macrophage colony-stimulating factor and human granulocyte colony-stimulating factor on hematopoiesis in human long-term marrow cultures.
Blood 1991;77(3):493-9.
1991: Eaves C J; Cashman J D; Sutherland H J; Otsuka T; Humphries R K; Hogge D E; Lansdorp P L; Eaves A C
Molecular analysis of primitive hematopoietic cell proliferation control mechanisms.
Annals of the New York Academy of Sciences 1991;628():298-306.
1990: Turhan A G; Humphries R K; Eaves C J; Barnett M J; Phillips G L; Kalousek D K; Klingemann H G; Lansdorp P L; Reece D E; Shepherd J D
Detection of breakpoint cluster region- negative and nonclonal hematopoiesis in vitro and in vivo after transplantation of cells selected in cultures of chronic myeloid leukemia marrow.
Blood 1990;76(11):2404-10.
1990: Szilvassy S J; Humphries R K; Lansdorp P M; Eaves A C; Eaves C J
Quantitative assay for totipotent reconstituting hematopoietic stem cells by a competitive repopulation strategy.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(22):8736-40.
1990: Fraser C C; Eaves C J; Szilvassy S J; Humphries R K
Expansion in vitro of retrovirally marked totipotent hematopoietic stem cells.
Blood 1990;76(6):1071-6.
1990: Kay R; Takei F; Humphries R K
Expression cloning of a cDNA encoding M1/69-J11d heat-stable antigens.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(6):1952-9.
1990: Wognum A W; Lansdorp P M; Humphries R K; Krystal G
Detection and isolation of the erythropoietin receptor using biotinylated erythropoietin.
Blood 1990;76(4):697-705.
1990: Kay R; Dougherty G J; Humphries R K
Heterogeneous modifications of the 114/A10 protein of interleukin-3-dependent cells are concentrated in a highly repetitive amino-terminal domain.
The Journal of biological chemistry 1990;265(9):4962-8.
1989: Hughes P F; Eaves C J; Hogge D E; Humphries R K
High-efficiency gene transfer to human hematopoietic cells maintained in long-term marrow culture.
Blood 1989;74(6):1915-22.
1989: Szilvassy S J; Fraser C C; Eaves C J; Lansdorp P M; Eaves A C; Humphries R K
Retrovirus-mediated gene transfer to purified hemopoietic stem cells with long-term lympho-myelopoietic repopulating ability.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(22):8798-802.
1989: Dougherty G J; Dougherty S T; Kay R J; Landsdorp P; Humphries R K
Identification and characterization of 114/A10, an antigen highly expressed on the surface of murine myeloid and erythroid progenitor cells and IL-3-dependent cell lines.
Experimental hematology 1989;17(8):877-82.
1989: Szilvassy S J; Lansdorp P M; Humphries R K; Eaves A C; Eaves C J
Isolation in a single step of a highly enriched murine hematopoietic stem cell population with competitive long-term repopulating ability.
Blood 1989;74(3):930-9.
1989: Turhan A G; Humphries R K; Phillips G L; Eaves A C; Eaves C J
Clonal hematopoiesis demonstrated by X-linked DNA polymorphisms after allogeneic bone marrow transplantation.
The New England journal of medicine 1989;320(25):1655-61.
1989: Dougherty G J; Kay R J; Humphries R K
Molecular cloning of 114/A10, a cell surface antigen containing highly conserved repeated elements, which is expressed by murine hemopoietic progenitor cells and interleukin-3-dependent cell lines.
The Journal of biological chemistry 1989;264(11):6509-14.
1988: Lemoine F M; Krystal G; Humphries R K; Eaves C J
Autocrine production of pre-B-cell stimulating activity by a variety of transformed murine pre-B-cell lines.
Cancer research 1988;48(22):6438-43.
1988: Humphries R K; Abraham S; Krystal G; Lansdorp P; Lemoine F; Eaves C J
Activation of multiple hemopoietic growth factor genes in Abelson virus-transformed myeloid cells.
Experimental hematology 1988;16(9):774-81.
1988: Lemoine F M; Humphries R K; Abraham S D; Krystal G; Eaves C J
Partial characterization of a novel stromal cell-derived pre-B-cell growth factor active on normal and immortalized pre-B cells.
Experimental hematology 1988;16(8):718-26.
1988: Turhan A G; Humphries R K; Cashman J D; Cuthbert D A; Eaves C J; Eaves A C
Transient suppression of clonal hemopoiesis associated with pregnancy in a patient with a myeloproliferative disorder.
The Journal of clinical investigation 1988;81(6):1999-2003.
1988: Fraser C; Humphries R K; Mager D L
Chromosomal distribution of the RTVL-H family of human endogenous retrovirus-like sequences.
Genomics 1988;2(4):280-7.
1988: Turhan A G; Eaves C J; Kalousek D K; Eaves A C; Humphries R K
Molecular analysis of clonality and bcr rearrangements in Philadelphia chromosome-positive acute lymphoblastic leukemia.
Blood 1988;71(5):1495-8.

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