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Keith Humphries

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Acute Myeloid Leukemia

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Paul H Miller; Gabrielle Rabu; Shabnam Rostamirad; R Keith Humphries; David J H F Knapp; Philip A Beer; Alice M S Cheung; Kiran Dhillon; Connie J Eaves
Enhanced normal short-term human myelopoiesis in mice engineered to express human-specific myeloid growth factors.
Coral-Ann B Lewis; John Manning; Kyle Peake; Fabio Rossi; Christine Barr; R Keith Humphries; Charles Krieger
Myelosuppressive conditioning using busulfan enables bone marrow cell accumulation in the spinal cord of a mouse model of amyotrophic lateral sclerosis.
I Sloma; Y Zhao; P A Beer; C Brimacombe; C Hansen; R Keith Humphries; Suzan Imren; K Lambie; V Lecault; D Leung; J Piret; K Raghuram; Connie J Eaves
Ex vivo expansion of normal and chronic myeloid leukemic stem cells without functional alteration using a NUP98HOXA10homeodomain fusion gene.

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2013: Paul H Miller; Gabrielle Rabu; Shabnam Rostamirad; R Keith Humphries; David J H F Knapp; Philip A Beer; Alice M S Cheung; Kiran Dhillon; Connie J Eaves
Enhanced normal short-term human myelopoiesis in mice engineered to express human-specific myeloid growth factors.
Blood 2013;121(5):e1-4.
2013: Coral-Ann B Lewis; John Manning; Kyle Peake; Fabio Rossi; Christine Barr; R Keith Humphries; Charles Krieger
Myelosuppressive conditioning using busulfan enables bone marrow cell accumulation in the spinal cord of a mouse model of amyotrophic lateral sclerosis.
PloS one 2013;8(4):e60661.
2013: I Sloma; Y Zhao; P A Beer; C Brimacombe; C Hansen; R Keith Humphries; Suzan Imren; K Lambie; V Lecault; D Leung; J Piret; K Raghuram; Connie J Eaves
Ex vivo expansion of normal and chronic myeloid leukemic stem cells without functional alteration using a NUP98HOXA10homeodomain fusion gene.
Leukemia 2013;27(1):159-69.
2012: Vincenzo Giambra; Sam Gusscott; R Keith Humphries; Christopher R Jenkins; Sonya H Lam; Oksana Nemirovsky; Olena O Shevchuk; Carol Wai; Hongfang Wang; Jon C Aster; Mark Chiang; Connie Eaves; Andrew P Weng
NOTCH1 promotes T cell leukemia-initiating activity by RUNX-mediated regulation of PKC-θ and reactive oxygen species.
Nature medicine 2012;18(11):1693-8.
2012: Maura Gasparetto; R Keith Humphries; Suzan Imren; David Kent; Sanja Sekulovic; Vasilis Vasiliou; Anush Zakaryan; Clay Smith
Varying levels of aldehyde dehydrogenase activity in adult murine marrow hematopoietic stem cells are associated with engraftment and cell cycle status.
Experimental hematology 2012;40(10):857-66.e5.
2012: Vijay P S Rawat; R Keith Humphries; Christian Buske
Beyond Hox: the role of ParaHox genes in normal and malignant hematopoiesis.
Blood 2012;120(3):519-27.
2012: Samuel Gusscott; R Keith Humphries; Florian Kuchenbauer; Andrew P Weng
Notch-mediated repression of miR-223 contributes to IGF1R regulation in T-ALL.
Leukemia research 2012;36(7):905-11.
2012: Michael Heuser; T Berg; S Fung; Arnold Ganser; J Krauter; Florian Kuchenbauer; C K Lai; M Leung; G Lin; G Park; R Keith Humphries
Functional role of BAALC in leukemogenesis.
Leukemia 2012;26(3):532-6.
2011: Sanja Sekulovic; Clayton Smith; Adrian Wan; Christy Brookes; Connie J Eaves; Maura Gasparetto; Carl L Hansen; Corinne A Hoesli; David Kent; Véronique Lecault; James M Piret; Patricia M Rosten; R Keith Humphries
Ontogeny stage-independent and high-level clonal expansion in vitro of mouse hematopoietic stem cells stimulated by an engineered NUP98-HOX fusion transcription factor.
Blood 2011;118(16):4366-76.
2011: Florian Kuchenbauer; David Lai; Sarah M Mah; Marco A Marra; Andrew McPherson; Ryan D Morin; Lars Palmqvist; Arefeh Rouhi; Jens Rüschmann; Daniel T Starczynowski; Yuzhuo Wang; Akira Watahiki; Samuel A Aparicio; Bob Argiropoulos; Tobias Berg; Lars Bullinger; Christian Buske; Fernando D Camargo; Hartmut Döhner; Konstanze Döhner; Connie J Eaves; Arnold Ganser; Michael Heuser; Aly Karsan; Jürgen Krauter; R Keith Humphries
Comprehensive analysis of mammalian miRNA* species and their role in myeloid cells.
Blood 2011;118(12):3350-8.
2011: Sanja Sekulovic; Clayton Smith; Irma Vulto; Peter M Lansdorp; Fabio M Rossi; Christy Brookes; Connie J Eaves; Yasmine Even; Maura Gasparetto; Vala Gylfadottir; R Keith Humphries
Prolonged self-renewal activity unmasks telomerase control of telomere homeostasis and function of mouse hematopoietic stem cells.
Blood 2011;118(7):1766-73.
2011: Michael Heuser; Martin Hirst; Bob Argiropoulos; Tobias Berg; Mikhail Bilenky; Anuhar Chaturvedi; Michael L Cleary; Connie Eaves; Arnold Ganser; Bertie Göttgens; Iyas Hamwi; Masayuki Iwasaki; David Kent; Florian Kuchenbauer; Courteney K Lai; Malina Leung; Grace Lin; Marco Marra; Lars Palmqvist; Gyeongsin Park; Gordon Robertson; Basant Kumar Thakur; Nina Thiessen; Nicola K Wilson; Haiyang Yun; Eric Yung; R Keith Humphries
Cell of origin in AML: susceptibility to MN1-induced transformation is regulated by the MEIS1/AbdB-like HOX protein complex.
Cancer cell 2011;20(1):39-52.
2011: Véronique Lecault; Thomas McLaughlin; Michelle Miller; James M Piret; Sanja Sekulovic; Fariborz Taghipour; Michael Vaninsberghe; Francis Viel; Adam K White; Stefan Wohrer; William Bowden; Michael R Copley; Connie J Eaves; Didier Falconnet; R Keith Humphries; Asefeh Jarandehei; David Kent; David J H F Knapp; Carl L Hansen
High-throughput analysis of single hematopoietic stem cell proliferation in microfluidic cell culture arrays.
Nature methods 2011;8(7):581-6.
2011: Eric Yung; Sanja Sekulovic; Bob Argiropoulos; Courteney K Lai; Malina Leung; Tobias Berg; Sarah Vollett; Vicky Chi-Dan Chang; Adrian Wan; Sandy Wong; R Keith Humphries
Delineating domains and functions of NUP98 contributing to the leukemogenic activity of NUP98-HOX fusions.
Leukemia research 2011;35(4):545-50.
2011: Damian Yap; Justin Chu; Tobias Berg; Matthieu Schapira; S-W Grace Cheng; Annie Moradian; Ryan D Morin; Andrew J Mungall; Barbara Meissner; Merrill Boyle; Victor E Marquez; Marco A Marra; Randy D Gascoyne; R Keith Humphries; Cheryl H Arrowsmith; Gregg B Morin; Samuel A J R Aparicio
Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation.
Blood 2011;117(8):2451-9.
2011: Daniel T Starczynowski; Florian Kuchenbauer; Joanna Wegrzyn; Arefeh Rouhi; Oleh Petriv; Carl L Hansen; R Keith Humphries; Aly Karsan
MicroRNA-146a disrupts hematopoietic differentiation and survival.
Experimental hematology 2011;39(2):167-178.e4.
2011: Daniel T Starczynowski; Ryan Morin; Andrew McPherson; Jeff Lam; Raj Chari; Joanna Wegrzyn; Florian Kuchenbauer; Martin Hirst; Kaoru Tohyama; R Keith Humphries; Wan L Lam; Marco Marra; Aly Karsan
Genome-wide identification of human microRNAs located in leukemia-associated genomic alterations.
Blood 2011;117(2):595-607.
2011: Oleh I Petriv; Carl L Hansen; R Keith Humphries; Florian Kuchenbauer
Probing the complexity of miRNA expression across hematopoiesis.
Cell cycle (Georgetown, Tex.) 2011;10(1):2-3.
2011: Suzan Imren; Xiao-Bing Zhang; R Keith Humphries; Hans-Peter Kiem
Insights into leukemia-initiating cell frequency and self-renewal from a novel canine model of leukemia.
Experimental hematology 2011;39(1):124-32.
2010: Bob Argiropoulos; Lars Palmqvist; Suzan Imren; M Miller; Arefeh Rouhi; Dixie L Mager; R Keith Humphries
Meis1 disrupts the genomic imprint of Dlk1 in a NUP98-HOXD13 leukemia model.
Leukemia 2010;24(10):1788-91.
2010: Guy Sauvageau; R Keith Humphries
Medicine. The blood stem cell Holy Grail?
Science (New York, N.Y.) 2010;329(5997):1291-2.
2010: Ping Xiang; Chaoyu Lo; Bob Argiropoulos; C Benjamin Lai; Arefeh Rouhi; Suzan Imren; Xiaoyan Jiang; Dixie L Mager; R Keith Humphries
Identification of E74-like factor 1 (ELF1) as a transcriptional regulator of the Hox cofactor MEIS1.
Experimental hematology 2010;38(9):798-8, 808.e1-2.
2010: O I Petriv; F Kuchenbauer; Allen D Delaney; V Lecault; A White; David Kent; L Marmolejo; M Heuser; T Berg; M Copley; Jens Ruschmann; S Sekulovic; C Benz; E Kuroda; Victor Ho; F Antignano; T Halim; V Giambra; Gerald Krystal; C J F Takei; A P Weng; James M Piret; Connie Eaves; Marco A Marra; R Keith Humphries; C L Hansen
Comprehensive microRNA expression profiling of the hematopoietic hierarchy.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(35):15443-8.
2010: Connie J Eaves; R Keith Humphries
Acute myeloid leukemia and the Wnt pathway.
The New England journal of medicine 2010;362(24):2326-7.
2010: Bob Argiropoulos; Eric Yung; Ping Xiang; Chao Yu Lo; Florian Kuchenbauer; Lars Palmqvist; Carola Reindl; Michael Heuser; Sanja Sekulovic; Patricia M Rosten; Andrew Muranyi; Siew-Lee Goh; Mark Featherstone; R Keith Humphries
Linkage of the potent leukemogenic activity of Meis1 to cell-cycle entry and transcriptional regulation of cyclin D3.
Blood 2010;115(20):4071-82.
2010: Michael Heuser; R Keith Humphries
Biologic and experimental variation of measured cancer stem cells.
Cell cycle (Georgetown, Tex.) 2010;9(5):909-12.
2010: Michael Heuser; Gyeongsin Park; Yeonsook Moon; Tobias Berg; Ping Xiang; Florian Kuchenbauer; Sarah Vollett; Courteney Lai; R Keith Humphries
Extrinsic signals determine myeloid-erythroid lineage switch in MN1 leukemia.
Experimental hematology 2010;38(3):174-9.
2010: Cynthia L Fisher; Nicolas Pineault; Christy Brookes; Cheryl D Helgason; Hideaki Ohta; Caroline Bodner; Jay L Hess; R Keith Humphries; Hugh W Brock
Loss-of-function Additional sex combs like 1 mutations disrupt hematopoiesis but do not cause severe myelodysplasia or leukemia.
Blood 2010;115(1):38-46.
2010: Daniel T Starczynowski; Florian Kuchenbauer; Bob Argiropoulos; Sandy Sung; Ryan Morin; Andrew Muranyi; Martin Hirst; Donna Hogge; Marco Marra; Richard A Wells; Rena Buckstein; Wan Lam; R Keith Humphries; Aly Karsan
Identification of miR-145 and miR-146a as mediators of the 5q- syndrome phenotype.
Nature medicine 2010;16(1):49-58.
2010: Cynthia L Fisher; I Lee; S Bloyer; S Bozza; J Chevalier; A Dahl; C Bodner; C D Helgason; Jay L Hess; R Keith Humphries; Hugh W Brock
Additional sex combs-like 1 belongs to the enhancer of trithorax and polycomb group and genetically interacts with Cbx2 in mice.
Developmental biology 2010;337(1):9-15.
2009: Michael Heuser; Laura M Sly; Bob Argiropoulos; Florian Kuchenbauer; Courteney Lai; Andrew Weng; Malina Leung; Grace Lin; Christy Brookes; Stephen Fung; Peter J Valk; Ruud Delwel; Bob Löwenberg; Gerald Krystal; R Keith Humphries
Modeling the functional heterogeneity of leukemia stem cells: role of STAT5 in leukemia stem cell self-renewal.
Blood 2009;114(19):3983-93.
2009: Michael Heuser; Florian Kuchenbauer; Bob Argiropoulos; Sanja Sekulovic; Malina Leung; marcin stasiak; Arnold Ganser; R Keith Humphries
Priming reloaded?
Blood 2009;114(4):925-6; author reply 926-7.
2009: Michael Heuser; Damian Yap; Malina Leung; Teresa Ruiz de Algara; Alaeddin Tafech; Steven McKinney; Dixon John; Rosemary Thresher; Bill Colledge; Mark Carlton; R Keith Humphries; Samuel A Aparicio
Loss of MLL5 results in pleiotropic hematopoietic defects, reduced neutrophil immune function, and extreme sensitivity to DNA demethylation.
Blood 2009;113(7):1432-43.
2008: Florian Kuchenbauer; Ryan D Morin; Bob Argiropoulos; Oleh I Petriv; Malachi Griffith; Michael Heuser; Eric Yung; Jessica Piper; Allen Delaney; Anna-Liisa Prabhu; Yongjun Zhao; Helen McDonald; Thomas Zeng; Martin Hirst; Carl L Hansen; Marco A Marra; R Keith Humphries
In-depth characterization of the microRNA transcriptome in a leukemia progression model.
Genome research 2008;18(11):1787-97.
2008: K Hirose; Carolina Abramovich; Bob Argiropoulos; R Keith Humphries
Leukemogenic properties of NUP98-PMX1 are linked to NUP98 and homeodomain sequence functions but not to binding properties of PMX1 to serum response factor.
Oncogene 2008;27(46):6056-67.
2008: Arefeh Rouhi; Dixie L Mager; R Keith Humphries; Florian Kuchenbauer
MiRNAs, epigenetics, and cancer.
Mammalian genome : official journal of the International Mammalian Genome Society 2008;19(7-8):517-25.
2008: Bob Argiropoulos; Lars Palmqvist; Eric Yung; Florian Kuchenbauer; Michael Heuser; Laura M Sly; Adrian Wan; Gerald Krystal; R Keith Humphries
Linkage of Meis1 leukemogenic activity to multiple downstream effectors including Trib2 and Ccl3.
Experimental hematology 2008;36(7):845-59.
2008: Amélie Faubert; Jalila Chagraoui; Nadine Mayotte; M Fréchette; N N Iscove; R Keith Humphries; Guy Sauvageau
Complementary and independent function for Hoxb4 and Bmi1 in HSC activity.
Cold Spring Harbor symposia on quantitative biology 2008;73():555-64.
2007: Bob Argiropoulos; Eric Yung; R Keith Humphries
Unraveling the crucial roles of Meis1 in leukemogenesis and normal hematopoiesis.
Genes & development 2007;21(22):2845-9.
2007: Bob Argiropoulos; R Keith Humphries
Hox genes in hematopoiesis and leukemogenesis.
Oncogene 2007;26(47):6766-76.
2007: Michael Heuser; Bob Argiropoulos; Florian Kuchenbauer; Eric Yung; Jessica Piper; Stephen Fung; Richard F Schlenk; Konstanze Dohner; Tanja Hinrichsen; Cornelia Rudolph; Axel Schambach; Christopher Baum; Brigitte Schlegelberger; Hartmut Dohner; Arnold Ganser; R Keith Humphries
MN1 overexpression induces acute myeloid leukemia in mice and predicts ATRA resistance in patients with AML.
Blood 2007;110(5):1639-47.
2007: Min Lu; Clive H Glover; Amy H Tien; R Keith Humphries; James M Piret; Cheryl D Helgason
Involvement of tyrosine kinase signaling in maintaining murine embryonic stem cell functionality.
Experimental hematology 2007;35(8):1293-302.
2007: Hideaki Ohta; Sanja Sekulovic; Silvia Bakovic; Connie J Eaves; Nicolas Pineault; Maura Gasparetto; Clayton Smith; Guy Sauvageau; R Keith Humphries
Near-maximal expansions of hematopoietic stem cells in culture using NUP98-HOX fusions.
Experimental hematology 2007;35(5):817-30.
2007: Sonia Cellot; Jana Krosl; Jalila Chagraoui; Sylvain Meloche; R Keith Humphries; Guy Sauvageau
Sustained in vitro trigger of self-renewal divisions in Hoxb4hiPbx1(10) hematopoietic stem cells.
Experimental hematology 2007;35(5):802-16.
2007: Lars Palmqvist; Nicolas Pineault; Carina Wasslavik; R Keith Humphries
Candidate genes for expansion and transformation of hematopoietic stem cells by NUP98-HOX fusion genes.
PloS one 2007;2(8):e768.
2006: Aniruddha J Deshpande; Monica Cusan; Vijay P S Rawat; Hendrik Reuter; Alexandre Krause; Christiane Pott; Leticia Quintanilla-Martinez; Purvi Kakadia; Florian Kuchenbauer; Farid Ahmed; Eric Delabesse; Meinhard Hahn; Peter Lichter; Michael Kneba; Wolfgang Hiddemann; Elizabeth Macintyre; Cristina Mecucci; Wolf-Dieter Ludwig; R Keith Humphries; Stefan K Bohlander; Michaela Feuring-Buske; Christian Buske
Acute myeloid leukemia is propagated by a leukemic stem cell with lymphoid characteristics in a mouse model of CALM/AF10-positive leukemia.
Cancer cell 2006;10(5):363-74.
2006: Rhonna M Gurevich; Patricia M Rosten; Maike Schwieger; Carol Stocking; R Keith Humphries
Retroviral integration site analysis identifies ICSBP as a collaborating tumor suppressor gene in NUP98-TOP1-induced leukemia.
Experimental hematology 2006;34(9):1192-201.
2006: Lars Palmqvist; Bob Argiropoulos; Nicolas Pineault; Carolina Abramovich; Laura M Sly; Gerald Krystal; Adrian Wan; R Keith Humphries
The Flt3 receptor tyrosine kinase collaborates with NUP98-HOX fusions in acute myeloid leukemia.
Blood 2006;108(3):1030-6.
2006: Cynthia L Fisher; Filippo Randazzo; R Keith Humphries; Hugh W Brock
Characterization of Asxl1, a murine homolog of Additional sex combs, and analysis of the Asx-like gene family.
Gene 2006;369():109-18.
2005: H Jeffrey Lawrence; Julie Christensen; Sylvia Fong; Yu-Long Hu; Irving Weissman; Guy Sauvageau; R Keith Humphries; Corey Largman
Loss of expression of the Hoxa-9 homeobox gene impairs the proliferation and repopulating ability of hematopoietic stem cells.
Blood 2005;106(12):3988-94.
2005: Christina Schessl; Vijay P S Rawat; Monica Cusan; Aniruddha Deshpande; Tobias M Kohl; Patricia M Rosten; Karsten Spiekermann; R Keith Humphries; Susanne Schnittger; Wolfgang Kern; Wolfgang Hiddemann; Leticia Quintanilla-Martinez; Stefan K Bohlander; Michaela Feuring-Buske; Christian Buske
The AML1-ETO fusion gene and the FLT3 length mutation collaborate in inducing acute leukemia in mice.
The Journal of clinical investigation 2005;115(8):2159-68.
2005: Carolina Abramovich; Nicolas Pineault; Hideaki Ohta; R Keith Humphries
Hox genes: from leukemia to hematopoietic stem cell expansion.
Annals of the New York Academy of Sciences 2005;1044():109-16.
2005: Carolina Abramovich; R Keith Humphries
Hox regulation of normal and leukemic hematopoietic stem cells.
Current opinion in hematology 2005;12(3):210-6.
2005: Lars Palmqvist; Clive H Glover; Lien Hsu; Min Lu; Bolette Bossen; James M Piret; R Keith Humphries; Cheryl D Helgason
Correlation of murine embryonic stem cell gene expression profiles with functional measures of pluripotency.
Stem cells (Dayton, Ohio) 2005;23(5):663-80.
2005: Christina M Ferrell; Sheri Tinnell Dorsam; Hideaki Ohta; R Keith Humphries; Mika Kakefuda Derynck; Christopher Haqq; Corey Largman; H Jeffrey Lawrence
Activation of stem-cell specific genes by HOXA9 and HOXA10 homeodomain proteins in CD34+ human cord blood cells.
Stem cells (Dayton, Ohio) 2005;23(5):644-55.
2005: Nicolas Pineault; Carolina Abramovich; R Keith Humphries
Transplantable cell lines generated with NUP98-Hox fusion genes undergo leukemic progression by Meis1 independent of its binding to DNA.
Leukemia 2005;19(4):636-43.
2004: Suzan Imren; Mary E Fabry; Karen A Westerman; Robert Pawliuk; Patrick Tang; Patricia M Rosten; Ronald L Nagel; Philippe Leboulch; Connie J Eaves; R Keith Humphries
High-level beta-globin expression and preferred intragenic integration after lentiviral transduction of human cord blood stem cells.
The Journal of clinical investigation 2004;114(7):953-62.
2004: Guy Sauvageau; Norman N Iscove; R Keith Humphries
In vitro and in vivo expansion of hematopoietic stem cells.
Oncogene 2004;23(43):7223-32.
2004: Il-Hoan Oh; Mary E Fabry; R Keith Humphries; Robert Pawliuk; Philippe Leboulch; Ronald Hoffman; Ronald L Nagel; Connie Eaves
Expression of an anti-sickling beta-globin in human erythroblasts derived from retrovirally transduced primitive normal and sickle cell disease hematopoietic cells.
Experimental hematology 2004;32(5):461-9.
2004: Nicolas Pineault; Carolina Abramovich; Hideaki Ohta; R Keith Humphries
Differential and common leukemogenic potentials of multiple NUP98-Hox fusion proteins alone or with Meis1.
Molecular and cellular biology 2004;24(5):1907-17.
2004: Frank Nicolini; Johanne Cashman; Donna E Hogge; R Keith Humphries; Connie J Eaves
NOD/SCID mice engineered to express human IL-3, GM-CSF and Steel factor constitutively mobilize engrafted human progenitors and compromise human stem cell regeneration.
Leukemia 2004;18(2):341-7.
2004: Vijay P S Rawat; Monica Cusan; Aniruddha Deshpande; Wolfgang Hiddemann; Leticia Quintanilla-Martinez; R Keith Humphries; Stefan K Bohlander; Michaela Feuring-Buske; Christian Buske
Ectopic expression of the homeobox gene Cdx2 is the transforming event in a mouse model of t(12;13)(p13;q12) acute myeloid leukemia.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(3):817-22.
2003: Cheryl D Helgason; Jennifer Antonchuk; Caroline Bodner; R Keith Humphries
Homeostasis and regeneration of the hematopoietic stem cell pool are altered in SHIP-deficient mice.
Blood 2003;102(10):3541-7.
2003: Jana Krosl; Pamela Austin; Nathalie Beslu; Evert Kroon; R Keith Humphries; Guy Sauvageau
In vitro expansion of hematopoietic stem cells by recombinant TAT-HOXB4 protein.
Nature medicine 2003;9(11):1428-32.
2003: Bruno Larrivée; David R Lane; Ingrid Pollet; Peggy L Olive; R Keith Humphries; Aly Karsan
Vascular endothelial growth factor receptor-2 induces survival of hematopoietic progenitor cells.
The Journal of biological chemistry 2003;278(24):22006-13.
2003: Nicolas Pineault; Christian Buske; Michaela Feuring-Buske; Carolina Abramovich; Patricia M Rosten; Donna E Hogge; Peter D Aplan; R Keith Humphries
Induction of acute myeloid leukemia in mice by the human leukemia-specific fusion gene NUP98-HOXD13 in concert with Meis1.
Blood 2003;101(11):4529-38.
2003: Jana Krosl; Nathalie Beslu; Nadine Mayotte; R Keith Humphries; Guy Sauvageau
The competitive nature of HOXB4-transduced HSC is limited by PBX1: the generation of ultra-competitive stem cells retaining full differentiation potential.
Immunity 2003;18(4):561-71.
2003: Michaela Feuring-Buske; Brigitte Gerhard; J Cashman; R Keith Humphries; Connie J Eaves; Donna E Hogge
Improved engraftment of human acute myeloid leukemia progenitor cells in beta 2-microglobulin-deficient NOD/SCID mice and in NOD/SCID mice transgenic for human growth factors.
Leukemia 2003;17(4):760-3.
2002: Suzan Imren; Emmanuel Payen; Karen A Westerman; Robert Pawliuk; Mary E Fabry; Connie J Eaves; Benjamin Cavilla; Louis D Wadsworth; Yves Beuzard; Eric E Bouhassira; Robert Russell; Irving M London; Ronald L Nagel; Philippe Leboulch; R Keith Humphries
Permanent and panerythroid correction of murine beta thalassemia by multiple lentiviral integration in hematopoietic stem cells.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(22):14380-5.
2002: Carolina Abramovich; Liz Chavez; Peter M Lansdorp; R Keith Humphries
Functional characterization of multiple domains involved in the subcellular localization of the hematopoietic Pbx interacting protein (HPIP).
Oncogene 2002;21(44):6766-71.
2002: Cindy L Miller; Suzan Imren; Jennifer Antonchuk; Christian Kalberer; Mary E Fabry; Ronald L Nagel; R Keith Humphries; Connie J Eaves
Feasibility of using autologous transplantation to evaluate hematopoietic stem cell-based gene therapy strategies in transgenic mouse models of human disease.
Molecular therapy : the journal of the American Society of Gene Therapy 2002;6(3):422-8.
2002: Sunao Takeshita; Noriyuki Namba; Jenny J Zhao; Yebin Jiang; Harry K Genant; Matthew J Silva; Michael D Brodt; Cheryl D Helgason; Janet Kalesnikoff; Michael J Rauh; R Keith Humphries; Gerald Krystal; Steven L Teitelbaum; F Patrick Ross
SHIP-deficient mice are severely osteoporotic due to increased numbers of hyper-resorptive osteoclasts.
Nature medicine 2002;8(9):943-9.
2002: Frank Nicolini; Suzan Imren; Il-Hoan Oh; R Keith Humphries; Philippe Leboulch; Mary E Fabry; Ronald L Nagel; Connie J Eaves
Expression of a human beta-globin transgene in erythroid cells derived from retrovirally transduced transplantable human fetal liver and cord blood cells.
Blood 2002;100(4):1257-64.
2002: Christian Buske; Michaela Feuring-Buske; Carolina Abramovich; Karsten Spiekermann; Connie J Eaves; Laure Coulombel; Guy Sauvageau; Donna E Hogge; R Keith Humphries
Deregulated expression of HOXB4 enhances the primitive growth activity of human hematopoietic cells.
Blood 2002;100(3):862-8.
2002: Jennifer Antonchuk; Guy Sauvageau; R Keith Humphries
HOXB4-induced expansion of adult hematopoietic stem cells ex vivo.
Cell 2002;109(1):39-45.
2002: Nicolas Pineault; Cheryl D Helgason; H Jeffrey Lawrence; R Keith Humphries
Differential expression of Hox, Meis1, and Pbx1 genes in primitive cells throughout murine hematopoietic ontogeny.
Experimental hematology 2002;30(1):49-57.
2001: Robert Pawliuk; Karen A Westerman; Mary E Fabry; Emmanuel Payen; robert Tighe; Eric E Bouhassira; Seetharama A Acharya; James Ellis; Irving M London; Connie J Eaves; R Keith Humphries; Yves Beuzard; Ronald L Nagel; Philippe Leboulch
Correction of sickle cell disease in transgenic mouse models by gene therapy.
Science (New York, N.Y.) 2001;294(5550):2368-71.
2001: Jennifer Antonchuk; Guy Sauvageau; R Keith Humphries
HOXB4 overexpression mediates very rapid stem cell regeneration and competitive hematopoietic repopulation.
Experimental hematology 2001;29(9):1125-34.
2001: Nathalie Rufer; Marco Migliaccio; Jennifer Antonchuk; R Keith Humphries; Eddy Roosnek; P M Lansdorp
Transfer of the human telomerase reverse transcriptase (TERT) gene into T lymphocytes results in extension of replicative potential.
Blood 2001;98(3):597-603.
2001: Christian Buske; Michaela Feuring-Buske; Jennifer Antonchuk; Patricia M Rosten; Donna E Hogge; Connie J Eaves; R Keith Humphries
Overexpression of HOXA10 perturbs human lymphomyelopoiesis in vitro and in vivo.
Blood 2001;97(8):2286-92.
2000: B Hennemann; Il-Hoan Oh; Jean Y Chuo; Christian Kalberer; P D Schley; S Rose-John; R Keith Humphries; Connie J Eaves
Efficient retrovirus-mediated gene transfer to transplantable human bone marrow cells in the absence of fibronectin.
Blood 2000;96(7):2432-9.
2000: Carolina Abramovich; WF Shen; Nicolas Pineault; Suzan Imren; B Montpetit; Corey Largman; R Keith Humphries
Functional cloning and characterization of a novel nonhomeodomain protein that inhibits the binding of PBX1-HOX complexes to DNA.
The Journal of biological chemistry 2000;275(34):26172-7.
2000: Christian Buske; R Keith Humphries
Homeobox genes in leukemogenesis.
International journal of hematology 2000;71(4):301-8.
2000: Christian Kalberer; Robert Pawliuk; Suzan Imren; Thomas Bachelot; K J Takekoshi; Mary E Fabry; Connie J Eaves; Irving M London; R Keith Humphries; Philippe Leboulch
Preselection of retrovirally transduced bone marrow avoids subsequent stem cell gene silencing and age-dependent extinction of expression of human beta-globin in engrafted mice.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(10):5411-5.
2000: Cheryl D Helgason; Christian Kalberer; Jacqueline E Damen; S M Chappel; Nicolas Pineault; Gerald Krystal; R Keith Humphries
A dual role for Src homology 2 domain-containing inositol-5-phosphatase (SHIP) in immunity: aberrant development and enhanced function of b lymphocytes in ship -/- mice.
The Journal of experimental medicine 2000;191(5):781-94.
2000: Martina Metzler; Cheryl D Helgason; Ioannis Dragatsis; T Zhang; Lu Gan; Nicolas Pineault; Scott Zeitlin; R Keith Humphries; Michael R Hayden
Huntingtin is required for normal hematopoiesis.
Human molecular genetics 2000;9(3):387-94.
2000: B Hennemann; Jean Y Chuo; P D Schley; K Lambie; R Keith Humphries; Connie J Eaves
High-efficiency retroviral transduction of mammalian cells on positively charged surfaces.
Human gene therapy 2000;11(1):43-51.
1999: LE Ailles; R Keith Humphries; T E Thomas; Donna E Hogge
Retroviral marking of acute myelogenous leukemia progenitors that initiate long-term culture and growth in immunodeficient mice.
Experimental hematology 1999;27(11):1609-20.
1999: Unnur Thorsteinsdottir; Guy Sauvageau; R Keith Humphries
Enhanced in vivo regenerative potential of HOXB4-transduced hematopoietic stem cells with regulation of their pool size.
Blood 1999;94(8):2605-12.
1999: Gerald Krystal; Jacqueline E Damen; Cheryl D Helgason; Michael Huber; Michael R. Hughes; Janet Kalesnikoff; Vivian Lam; Patricia M Rosten; MD Ware; S Yew; R Keith Humphries
SHIPs ahoy.
The international journal of biochemistry & cell biology 1999;31(10):1007-10.
1999: H Kawagoe; R Keith Humphries; A Blair; Heather J Sutherland; Donna E Hogge
Expression of HOX genes, HOX cofactors, and MLL in phenotypically and functionally defined subpopulations of leukemic and normal human hematopoietic cells.
Leukemia 1999;13(5):687-98.
1999: B Hennemann; Eibhlin Conneally; Robert Pawliuk; Philippe Leboulch; S Rose-John; D Reid; Jean Y Chuo; R Keith Humphries; Connie J Eaves
Optimization of retroviral-mediated gene transfer to human NOD/SCID mouse repopulating cord blood cells through a systematic analysis of protocol variables.
Experimental hematology 1999;27(5):817-25.
1999: James Doheny; Eric J Jervis; M Marta Guarna; R Keith Humphries; R Antony J Warren; Douglas G Kilburn
Cellulose as an inert matrix for presenting cytokines to target cells: production and properties of a stem cell factor-cellulose-binding domain fusion protein.
The Biochemical journal 1999;339 ( Pt 2)():429-34.
1999: Michael Huber; Cheryl D Helgason; Jacqueline E Damen; Michael P Scheid; Vincent Duronio; Vivian Lam; R Keith Humphries; Gerald Krystal
The role of the SRC homology 2-containing inositol 5'-phosphatase in Fc epsilon R1-induced signaling.
Current topics in microbiology and immunology 1999;244():29-41.
1999: Michael Huber; Cheryl D Helgason; Jacqueline E Damen; Michael P Scheid; Vincent Duronio; L Liu; MD Ware; R Keith Humphries; Gerald Krystal
The role of SHIP in growth factor induced signalling.
Progress in biophysics and molecular biology 1999;71(3-4):423-34.
1998: Michael Huber; Cheryl D Helgason; Michael P Scheid; Vincent Duronio; R Keith Humphries; Gerald Krystal
Targeted disruption of SHIP leads to Steel factor-induced degranulation of mast cells.
The EMBO journal 1998;17(24):7311-9.
1998: Michael Huber; Cheryl D Helgason; Jacqueline E Damen; Lidong Liu; R Keith Humphries; Gerald Krystal
The src homology 2-containing inositol phosphatase (SHIP) is the gatekeeper of mast cell degranulation.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(19):11330-5.
1998: Robert Pawliuk; Thomas Bachelot; Harry Raftopoulos; Christian Kalberer; R Keith Humphries; Arthur Bank; Philippe Leboulch
Retroviral vectors aimed at the gene therapy of human beta-globin gene disorders.
Annals of the New York Academy of Sciences 1998;850():151-62.
1998: Cheryl D Helgason; Jacqueline E Damen; Patricia M Rosten; R Grewal; P Sorensen; S M Chappel; A Borowski; Frank R Jirik; Gerald Krystal; R Keith Humphries
Targeted disruption of SHIP leads to hemopoietic perturbations, lung pathology, and a shortened life span.
Genes & development 1998;12(11):1610-20.
1998: Eibhlin Conneally; Connie J Eaves; R Keith Humphries
Efficient retroviral-mediated gene transfer to human cord blood stem cells with in vivo repopulating potential.
Blood 1998;91(9):3487-93.
1997: Unnur Thorsteinsdottir; Guy Sauvageau; R Keith Humphries
Hox homeobox genes as regulators of normal and leukemic hematopoiesis.
Hematology/oncology clinics of North America 1997;11(6):1221-37.
1997: Robert Pawliuk; Connie J Eaves; R Keith Humphries
Sustained high-level reconstitution of the hematopoietic system by preselected hematopoietic cells expressing a transduced cell-surface antigen.
Human gene therapy 1997;8(13):1595-604.
1997: P Bardy; Eibhlin Conneally; Joanne T Emerman; P M Lansdorp; G Goss; R Keith Humphries; Connie J Eaves
Isolation and analysis of different subpopulations of normal human breast epithelial cells after their infection with a retroviral vector encoding a cell surface marker.
Breast cancer research and treatment 1997;44(2):153-65.
1997: Jacqueline E Damen; L Liu; H Wakao; Atsushi Miyajima; Patricia M Rosten; A B Jefferson; Philip W Majerus; Jana Krosl; R Keith Humphries; Gerald Krystal
The role of erythropoietin receptor tyrosine phosphorylation in erythropoietin-induced proliferation.
Leukemia 1997;11 Suppl 3():423-5.
1997: H Jeffrey Lawrence; Cheryl D Helgason; Guy Sauvageau; Sylvia Fong; D J Izon; R Keith Humphries; Corey Largman
Mice bearing a targeted interruption of the homeobox gene HOXA9 have defects in myeloid, erythroid, and lymphoid hematopoiesis.
Blood 1997;89(6):1922-30.
1997: Guy Sauvageau; Unnur Thorsteinsdottir; M R Hough; P Hugo; H Jeffrey Lawrence; Corey Largman; R Keith Humphries
Overexpression of HOXB3 in hematopoietic cells causes defective lymphoid development and progressive myeloproliferation.
Immunity 1997;6(1):13-22.
1997: Unnur Thorsteinsdottir; Guy Sauvageau; M R Hough; W Dragowska; Peter M Lansdorp; H Jeffrey Lawrence; Corey Largman; R Keith Humphries
Overexpression of HOXA10 in murine hematopoietic cells perturbs both myeloid and lymphoid differentiation and leads to acute myeloid leukemia.
Molecular and cellular biology 1997;17(1):495-505.
1996: M S Chappel; M R Hough; A Mittel; Fumio Takei; R Kay; R Keith Humphries
Cross-linking the murine heat-stable antigen induces apoptosis in B cell precursors and suppresses the anti-CD40-induced proliferation of mature resting B lymphocytes.
The Journal of experimental medicine 1996;184(5):1639-49.
1996: Jana Krosl; Jacqueline E Damen; Gerald Krystal; R Keith Humphries
Interleukin-3 (IL-3) inhibits erythropoietin-induced differentiation in Ba/F3 cells via the IL-3 receptor alpha subunit.
The Journal of biological chemistry 1996;271(44):27432-7.
1996: Robert Pawliuk; C Eaves; R Keith Humphries
Evidence of both ontogeny and transplant dose-regulated expansion of hematopoietic stem cells in vivo.
Blood 1996;88(8):2852-8.
1996: MD Ware; Patricia M Rosten; Jacqueline E Damen; Lidong Liu; R Keith Humphries; Gerald Krystal
Cloning and characterization of human SHIP, the 145-kD inositol 5-phosphatase that associates with SHC after cytokine stimulation.
Blood 1996;88(8):2833-40.
1996: H Jeffrey Lawrence; Guy Sauvageau; R Keith Humphries; Corey Largman
The role of HOX homeobox genes in normal and leukemic hematopoiesis.
Stem cells (Dayton, Ohio) 1996;14(3):281-91.
1996: C D Helgason; Guy Sauvageau; H Jeffrey Lawrence; Corey Largman; R Keith Humphries
Overexpression of HOXB4 enhances the hematopoietic potential of embryonic stem cells differentiated in vitro.
Blood 1996;87(7):2740-9.
1996: Jeffrey A Medin; M Migita; Robert Pawliuk; Steven Jacobson; M Amiri; S Kluepfel-Stahl; Roscoe O Brady; R Keith Humphries; S Karlsson
A bicistronic therapeutic retroviral vector enables sorting of transduced CD34+ cells and corrects the enzyme deficiency in cells from Gaucher patients.
Blood 1996;87(5):1754-62.
1996: W F Shen; C P Chang; Sophia Rozenfeld; Guy Sauvageau; R Keith Humphries; M Lu; H Jeffrey Lawrence; Michael L Cleary; Corey Largman
Hox homeodomain proteins exhibit selective complex stabilities with Pbx and DNA.
Nucleic acids research 1996;24(5):898-906.
1996: Jacqueline E Damen; Lidong Liu; Patricia M Rosten; R Keith Humphries; A B Jefferson; Philip W Majerus; Gerald Krystal
The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(4):1689-93.
1996: Eibhlin Conneally; P Bardy; C J Eaves; T Thomas; S Chappel; E J Shpall; R Keith Humphries
Rapid and efficient selection of human hematopoietic cells expressing murine heat-stable antigen as an indicator of retroviral-mediated gene transfer.
Blood 1996;87(2):456-64.
1996: M R Hough; M S Chappel; Guy Sauvageau; Fumio Takei; R Kay; R Keith Humphries
Reduction of early B lymphocyte precursors in transgenic mice overexpressing the murine heat-stable antigen.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(2):479-88.
1995: M Migita; Jeffrey A Medin; Robert Pawliuk; Steven Jacobson; James W Nagle; S Anderson; M Amiri; R Keith Humphries; S Karlsson
Selection of transduced CD34+ progenitors and enzymatic correction of cells from Gaucher patients, with bicistronic vectors.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(26):12075-9.
1995: Jacqueline E Damen; H Wakao; Atsushi Miyajima; Jana Krosl; R Keith Humphries; R L Cutler; Gerald Krystal
Tyrosine 343 in the erythropoietin receptor positively regulates erythropoietin-induced cell proliferation and Stat5 activation.
The EMBO journal 1995;14(22):5557-68.
1995: Guy Sauvageau; Unnur Thorsteinsdottir; C J Eaves; H Jeffrey Lawrence; Corey Largman; Peter M Lansdorp; R Keith Humphries
Overexpression of HOXB4 in hematopoietic cells causes the selective expansion of more primitive populations in vitro and in vivo.
Genes & development 1995;9(14):1753-65.
1995: ME Lewis; I J Forsythe; Jamey D Marth; J D Brunzell; Michael R Hayden; R Keith Humphries
Retroviral-mediated gene transfer and expression of human lipoprotein lipase in somatic cells.
Human gene therapy 1995;6(7):853-63.
1995: Jana Krosl; Jacqueline E Damen; Gerald Krystal; R Keith Humphries
Erythropoietin and interleukin-3 induce distinct events in erythropoietin receptor-expressing BA/F3 cells.
Blood 1995;85(1):50-6.
1994: Guy Sauvageau; Peter M Lansdorp; C J Eaves; Donna E Hogge; W Dragowska; D S Reid; Corey Largman; H Jeffrey Lawrence; R Keith Humphries
Differential expression of homeobox genes in functionally distinct CD34+ subpopulations of human bone marrow cells.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(25):12223-7.
1994: Robert Pawliuk; R Kay; Peter M Lansdorp; R Keith Humphries
Selection of retrovirally transduced hematopoietic cells using CD24 as a marker of gene transfer.
Blood 1994;84(9):2868-77.
1994: Philippe Leboulch; G M Huang; R Keith Humphries; Y H Oh; C J Eaves; D Y Tuan; I M London
Mutagenesis of retroviral vectors transducing human beta-globin gene and beta-globin locus control region derivatives results in stable transmission of an active transcriptional structure.
The EMBO journal 1994;13(13):3065-76.
1994: M R Hough; Patricia M Rosten; T L Sexton; R Kay; R Keith Humphries
Mapping of CD24 and homologous sequences to multiple chromosomal loci.
Genomics 1994;22(1):154-61.
1994: Donna E Hogge; H J Sutherland; Johanne Cashman; Peter M Lansdorp; R Keith Humphries; C J Eaves
Cytokines acting early in human haematopoiesis.
Baillière's clinical haematology 1994;7(1):49-63.
1994: M R Hough; Fumio Takei; R Keith Humphries; R Kay
Defective development of thymocytes overexpressing the costimulatory molecule, heat-stable antigen.
The Journal of experimental medicine 1994;179(1):177-84.
1994: Vivienne Rebel; W Dragowska; C J Eaves; R Keith Humphries; Peter M Lansdorp
Amplification of Sca-1+ Lin- WGA+ cells in serum-free cultures containing steel factor, interleukin-6, and erythropoietin with maintenance of cells with long-term in vivo reconstituting potential.
Blood 1994;83(1):128-36.
1993: C C Fraser; J D Thacker; Donna E Hogge; D Fatur-Saunders; Fumio Takei; R Keith Humphries
Alterations in lymphopoiesis after hematopoietic reconstitution with IL-7 virus-infected bone marrow.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(5):2409-18.
1992: A L Mui; Robert J Kay; R Keith Humphries; Gerald Krystal
Ligand-induced phosphorylation of the murine interleukin 3 receptor signals its cleavage.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(22):10812-6.
1992: A G Turhan; Johanne Cashman; C J Eaves; R Keith Humphries; Allen Eaves
Variable expression of features of normal and neoplastic stem cells in patients with thrombocytosis.
British journal of haematology 1992;82(1):50-7.
1992: A L Mui; Robert J Kay; R Keith Humphries; Gerald Krystal
Purification of the murine interleukin 3 receptor.
The Journal of biological chemistry 1992;267(23):16523-30.
1992: P F Hughes; J D Thacker; Donna E Hogge; Heather J Sutherland; T E Thomas; Peter M Lansdorp; C J Eaves; R Keith Humphries
Retroviral gene transfer to primitive normal and leukemic hematopoietic cells using clinically applicable procedures.
The Journal of clinical investigation 1992;89(6):1817-24.
1992: C C Fraser; S J Szilvassy; C J Eaves; R Keith Humphries
Proliferation of totipotent hematopoietic stem cells in vitro with retention of long-term competitive in vivo reconstituting ability.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(5):1968-72.
1992: C J Eaves; Heather J Sutherland; C Udomsakdi; Peter M Lansdorp; S J Szilvassy; C C Fraser; R Keith Humphries; Michael J Barnett; G L Phillips; Allen Eaves
The human hematopoietic stem cell in vitro and in vivo.
Blood cells 1992;18(2):301-7.
1991: T Otsuka; C J Eaves; R Keith Humphries; Donna E Hogge; A C Eaves
Lack of evidence for abnormal autocrine or paracrine mechanisms underlying the uncontrolled proliferation of primitive chronic myeloid leukemia progenitor cells.
Leukemia 1991;5(10):861-8.
1991: R Kay; Patricia M Rosten; R Keith Humphries
CD24, a signal transducer modulating B cell activation responses, is a very short peptide with a glycosyl phosphatidylinositol membrane anchor.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(4):1412-6.
1991: A G Turhan; C J Eaves; R Keith Humphries; G L Phillips; Allen Eaves
Reversing clonality in leukemia.
Seminars in hematology 1991;28(3 Suppl 4):5-8.
1991: C J Eaves; Johanne Cashman; Robert J Kay; Graeme Dougherty; T Otsuka; L A Gaboury; Donna E Hogge; Peter M Lansdorp; Allen Eaves; R Keith Humphries
Mechanisms that regulate the cell cycle status of very primitive hematopoietic cells in long-term human marrow cultures. II. Analysis of positive and negative regulators produced by stromal cells within the adherent layer.
Blood 1991;78(1):110-7.
1991: C J Eaves; H J Sutherland; Johanne Cashman; T Otsuka; Peter M Lansdorp; R Keith Humphries; Allen Eaves; Donna E Hogge
Regulation of primitive human hematopoietic cells in long-term marrow culture.
Seminars in hematology 1991;28(2):126-31.
1991: Donna E Hogge; Johanne Cashman; R Keith Humphries; C J Eaves
Differential and synergistic effects of human granulocyte-macrophage colony-stimulating factor and human granulocyte colony-stimulating factor on hematopoiesis in human long-term marrow cultures.
Blood 1991;77(3):493-9.
1991: C J Eaves; Johanne Cashman; H J Sutherland; T Otsuka; R Keith Humphries; Donna E Hogge; P L Lansdorp; Allen Eaves
Molecular analysis of primitive hematopoietic cell proliferation control mechanisms.
Annals of the New York Academy of Sciences 1991;628():298-306.
1990: A G Turhan; R Keith Humphries; C J Eaves; Michael J Barnett; G L Phillips; D K Kalousek; H G Klingemann; P L Lansdorp; D E Reece; John D Shepherd
Detection of breakpoint cluster region- negative and nonclonal hematopoiesis in vitro and in vivo after transplantation of cells selected in cultures of chronic myeloid leukemia marrow.
Blood 1990;76(11):2404-10.
1990: S J Szilvassy; R Keith Humphries; Peter M Lansdorp; Allen Eaves; C J Eaves
Quantitative assay for totipotent reconstituting hematopoietic stem cells by a competitive repopulation strategy.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(22):8736-40.
1990: C C Fraser; C J Eaves; S J Szilvassy; R Keith Humphries
Expansion in vitro of retrovirally marked totipotent hematopoietic stem cells.
Blood 1990;76(6):1071-6.
1990: R Kay; F Takei; R Keith Humphries
Expression cloning of a cDNA encoding M1/69-J11d heat-stable antigens.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(6):1952-9.
1990: A W Wognum; Peter M Lansdorp; R Keith Humphries; Gerald Krystal
Detection and isolation of the erythropoietin receptor using biotinylated erythropoietin.
Blood 1990;76(4):697-705.
1990: R Kay; Graeme Dougherty; R Keith Humphries
Heterogeneous modifications of the 114/A10 protein of interleukin-3-dependent cells are concentrated in a highly repetitive amino-terminal domain.
The Journal of biological chemistry 1990;265(9):4962-8.
1989: P F Hughes; C J Eaves; Donna E Hogge; R Keith Humphries
High-efficiency gene transfer to human hematopoietic cells maintained in long-term marrow culture.
Blood 1989;74(6):1915-22.
1989: S J Szilvassy; C C Fraser; C J Eaves; Peter M Lansdorp; Allen Eaves; R Keith Humphries
Retrovirus-mediated gene transfer to purified hemopoietic stem cells with long-term lympho-myelopoietic repopulating ability.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(22):8798-802.
1989: Graeme Dougherty; S T Dougherty; Robert J Kay; P Landsdorp; R Keith Humphries
Identification and characterization of 114/A10, an antigen highly expressed on the surface of murine myeloid and erythroid progenitor cells and IL-3-dependent cell lines.
Experimental hematology 1989;17(8):877-82.
1989: S J Szilvassy; Peter M Lansdorp; R Keith Humphries; Allen Eaves; C J Eaves
Isolation in a single step of a highly enriched murine hematopoietic stem cell population with competitive long-term repopulating ability.
Blood 1989;74(3):930-9.
1989: A G Turhan; R Keith Humphries; G L Phillips; Allen Eaves; C J Eaves
Clonal hematopoiesis demonstrated by X-linked DNA polymorphisms after allogeneic bone marrow transplantation.
The New England journal of medicine 1989;320(25):1655-61.
1989: Graeme Dougherty; Robert J Kay; R Keith Humphries
Molecular cloning of 114/A10, a cell surface antigen containing highly conserved repeated elements, which is expressed by murine hemopoietic progenitor cells and interleukin-3-dependent cell lines.
The Journal of biological chemistry 1989;264(11):6509-14.
1988: francois Lemoine; Gerald Krystal; R Keith Humphries; C J Eaves
Autocrine production of pre-B-cell stimulating activity by a variety of transformed murine pre-B-cell lines.
Cancer research 1988;48(22):6438-43.
1988: R Keith Humphries; S Abraham; Gerald Krystal; Peter M Lansdorp; francois Lemoine; C J Eaves
Activation of multiple hemopoietic growth factor genes in Abelson virus-transformed myeloid cells.
Experimental hematology 1988;16(9):774-81.
1988: francois Lemoine; R Keith Humphries; S D Abraham; Gerald Krystal; C J Eaves
Partial characterization of a novel stromal cell-derived pre-B-cell growth factor active on normal and immortalized pre-B cells.
Experimental hematology 1988;16(8):718-26.
1988: A G Turhan; R Keith Humphries; Johanne Cashman; D A Cuthbert; C J Eaves; Allen Eaves
Transient suppression of clonal hemopoiesis associated with pregnancy in a patient with a myeloproliferative disorder.
The Journal of clinical investigation 1988;81(6):1999-2003.
1988: C Fraser; R Keith Humphries; Dixie L Mager
Chromosomal distribution of the RTVL-H family of human endogenous retrovirus-like sequences.
Genomics 1988;2(4):280-7.
1988: A G Turhan; C J Eaves; D K Kalousek; Allen Eaves; R Keith Humphries
Molecular analysis of clonality and bcr rearrangements in Philadelphia chromosome-positive acute lymphoblastic leukemia.
Blood 1988;71(5):1495-8.