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Steve Humphries

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Waqas Ahmed; Muhammad Ajmal; Humaira Ayub; Raheel Qamar; Moeen Riaz; Ahmed Sadeque; Ros A Whittall; Steve E Humphries
The genetic spectrum of familial hypercholesterolemia in Pakistan.
Geraldine Cambridge; Jackie A Cooper; Jonathan C Edwards; Jayshree Acharya; Steve E Humphries
Antibodies to citrullinated peptides and risk of coronary heart disease.
Philippa J Talmud; John Whittaker; Ros A Whittall; Jackie A Cooper; Olivier S Descamps; Fotios Drenos; Marta Futema; Seamus C Harrison; Aroon D Hingorani; Philip Howard; Frederik Karpe; Mika Kivimaki; Meena Kumari; Claudia Langenberg; Nicholas Lench; Kawah Li; H Andrew W Neil; Sonia Shah; Steve E Humphries
Use of low-density lipoprotein cholesterol gene score to distinguish patients with polygenic and monogenic familial hypercholesterolaemia: a case-control study.

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All Publications

2013: Waqas Ahmed; Muhammad Ajmal; Humaira Ayub; Raheel Qamar; Moeen Riaz; Ahmed Sadeque; Ros A Whittall; Steve E Humphries
The genetic spectrum of familial hypercholesterolemia in Pakistan.
Clinica chimica acta; international journal of clinical chemistry 2013;421():219-25.
2013: Geraldine Cambridge; Jackie A Cooper; Jonathan C Edwards; Jayshree Acharya; Steve E Humphries
Antibodies to citrullinated peptides and risk of coronary heart disease.
Atherosclerosis 2013;228(1):243-6.
2013: Philippa J Talmud; John Whittaker; Ros A Whittall; Jackie A Cooper; Olivier S Descamps; Fotios Drenos; Marta Futema; Seamus C Harrison; Aroon D Hingorani; Philip Howard; Frederik Karpe; Mika Kivimaki; Meena Kumari; Claudia Langenberg; Nicholas Lench; Kawah Li; H Andrew W Neil; Sonia Shah; Steve E Humphries
Use of low-density lipoprotein cholesterol gene score to distinguish patients with polygenic and monogenic familial hypercholesterolaemia: a case-control study.
Lancet 2013;381(9874):1293-301.
2013: Tina Shah; Reecha Sofat; Daniel I Swerdlow; Philippa J Talmud; John Whittaker; Delilah Zabaneh; Ian N M Day; Tom R Gaunt; Aroon D Hingorani; Michael Holmes; Steve E Humphries; Mika Kivimaki; Meena Kumari; Sonia Shah; Juan P Casas
Gene-centric analysis identifies variants associated with interleukin-6 levels and shared pathways with other inflammation markers.
Circulation. Cardiovascular genetics 2013;6(2):163-70.
2013: Sonia Shah; Tina Shah; George Davey Smith; Reecha Sofat; Daniel I Swerdlow; Philippa J Talmud; John Whittaker; Delilah Zabaneh; Juan P Casas; Jackie Cooper; Ian N M Day; Fotios Drenos; Shah Ebrahim; Tom R Gaunt; Aroon D Hingorani; Mika Kivimaki; Meena Kumari; Debbie A Lawlor; Jutta Palmen; Steve E Humphries
Influence of common genetic variation on blood lipid levels, cardiovascular risk, and coronary events in two British prospective cohort studies.
European heart journal 2013;34(13):972-81.
2013: Simon R Thompson; Endashaw Bekele; Neil Bradman; Olivia Creemer; Rosemary Ekong; Steve E Humphries; Ayele Tarekegn; Mark Thomas; Krishna R Veeramah
The frequency of an IL-18-associated haplotype in Africans.
European journal of human genetics : EJHG 2013;21(4):465-8.
2013: Kyriacos I Eleftheriou; Fares S Haddad; Steve E Humphries; Lindsay E James; Mike Loosemore; John R Payne; Dudley J Pennell; Jaikirty S Rawal; Julie Sanders; Michael J World; Fotios Drenos; Hugh E Montgomery
Bone structure and geometry in young men: the influence of smoking, alcohol intake and physical activity.
Bone 2013;52(1):17-26.
2012: Ebele Usifo; Ros A Whittall; Corin Yeats; Jacopo Celli; Sarah E A Leigh; Nicholas Lench; Andrew C R Martin; Christine A Orengo; Alison Taylor; Steve E Humphries
Low-density lipoprotein receptor gene familial hypercholesterolemia variant database: update and pathological assessment.
Annals of human genetics 2012;76(5):387-401.
2012: Seamus C Harrison; Michael V Holmes; Steve E Humphries
Mendelian randomisation, lipids, and cardiovascular disease.
Lancet 2012;380(9841):543-5.
2012: J Rawal; J Skipworth; Michael J World; John Payne; Zudin Puthucheary; F Dreno; Kyriacos I Eleftheriou; F Haddad; Steve E Humphries; M Loosemore; Hugh Montgomery
Relationship between calcaneal quantitative ultrasound and hip dual energy X-ray absorptiometry in young healthy men.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 2012;23(7):1947-56.
2012: Julie S Sanders; James R A Skipworth; Michael Mythen; David J Brull; Jackie A Cooper; Steve E Humphries; Hugh E Montgomery
Duration of preceding hypertension is associated with prolonged length of ICU stay.
International journal of cardiology 2012;157(2):180-4.
2012: T S Tang; S C Bain; Jackie A Cooper; Steve E Humphries; Steven J Hurel; H A Ireland; K W Li; S L Prior; Jeffrey W Stephens
Association between the rs1050450 glutathione peroxidase-1 (C > T) gene variant and peripheral neuropathy in two independent samples of subjects with diabetes mellitus.
Nutrition, metabolism, and cardiovascular diseases : NMCD 2012;22(5):417-25.
2012: Gie Ken-Dror; Mika Kivimaki; Meena Kumari; Steve E Humphries; Fotios Drenos
A genetic instrument for Mendelian randomization of fibrinogen.
European journal of epidemiology 2012;27(4):267-79.
2012: Sukhbir S Dhamrait; Steve E Humphries; Stephen H Day; John R Payne; James Skipworth; Alun G Williams; Michael J World; Hugh E Montgomery
Variation in the uncoupling protein 2 and 3 genes and human performance.
Journal of applied physiology (Bethesda, Md. : 1985) 2012;112(7):1122-7.
2012: Seamus C Harrison; Jackie A Cooper; Anders Hamsten; Kawah Li; Hugh Montgomery; Andrew Neil; Julie Sanders; Reecha Sofat; Jeffery W Stephens; Phillipa J Talmud; Steve E Humphries
Association of a sequence variant in DAB2IP with coronary heart disease.
European heart journal 2012;33(7):881-8.
2012: Kyriacos I Eleftheriou; Fares S Haddad; Steve E Humphries; Laurence E James; Anthony Kehoe; Mike Loosemore; John R Payne; Dudley J Pennell; Zudin A Puthucheary; Jaikirty S Rawal; James R Skipworth; Michael World; Fotios Drenos; Hugh E Montgomery
The Lichfield bone study: the skeletal response to exercise in healthy young men.
Journal of applied physiology (Bethesda, Md. : 1985) 2012;112(4):615-26.
2012: Andrew J P Smith; Stefan Stender; Philippa J Talmud; Anne Tybjaerg-Hansen; Per Eriksson; Lasse Folkersen; Claudia Giambartolomei; Aroon D Hingorani; Philip Howard; Meena Kumari; Jutta Palmen; Sonia Shah; Steve E Humphries
Use of allele-specific FAIRE to determine functional regulatory polymorphism using large-scale genotyping arrays.
PLoS genetics 2012;8(8):e1002908.
2012: Holly J Exeter; Lasse Folkersen; Anders Franco-Cereceda; Ferdinand Van't Hooft; Steve E Humphries; Anastasia Z Kalea; Jutta Palmen; Jackie A Cooper; Per Eriksson; Philippa J Talmud
Functional analysis of two PLA2G2A variants associated with secretory phospholipase A2-IIA levels.
PloS one 2012;7(7):e41139.
2012: Sarah L Prior; Steve C Bain; Amy R Clark; Steve E Humphries; Steven J Hurel; Danielle A Jones; Jeffrey W Stephens
Association of the PGC-1α rs8192678 variant with microalbuminuria in subjects with type 2 diabetes mellitus.
Disease markers 2012;32(6):363-9.
2012: Seamus C Harrison; Michael V Holmes; Obi Agu; Anastasia Z Kalea; Steve E Humphries
Genomic research to identify novel pathways in the development of abdominal aortic aneurysm.
Cardiology research and practice 2012;2012():852829.
2011: Gie Ken-Dror; Jackie A Cooper; Fotios Drenos; Steve E Humphries; Helen A Ireland
Free protein S level as a risk factor for coronary heart disease and stroke in a prospective cohort study of healthy United Kingdom men.
American journal of epidemiology 2011;174(8):958-68.
2011: Kira C Taylor; Russell P Tracy; Delilah Zabaneh; Nicholas L Smith; Weihong Tang; Joseph A Delaney; Aaron R Folsom; David Green; Aroon Hingorani; Steve E Humphries; Brendan J Keating; Mika Kivimaki; Meena Kumari; Ethan Lange; Leslie A Lange; Kari E North; Christopher J O'Donnell; Alexander P Reiner
A gene-centric association scan for Coagulation Factor VII levels in European and African Americans: the Candidate Gene Association Resource (CARe) Consortium.
Human molecular genetics 2011;20(17):3525-34.
2011: Laura Calabresi; Samuela Castelnuovo; Ulf de Faire; Guido Franceschini; Beatrice Frigerio; Philippe Giral; Monica Gomaraschi; Anders Hamsten; Steve E Humphries; Jussi Kauhanen; Elmo Mannarino; Rainer Rauramaa; Alessio Ravani; Daniela Sansaro; Sara Simonelli; Cesare R Sirtori; Andries J Smit; Mauro Amato; Damiano Baldassarre; Fabrizio Veglia; Elena Tremoli
Plasma lecithin:cholesterol acyltransferase and carotid intima-media thickness in European individuals at high cardiovascular risk.
Journal of lipid research 2011;52(8):1569-74.
2011: Delilah Zabaneh; Juan P Casas; Robert Clarke; Fotios Drenos; Gerry Fowkes; Aroon D Hingorani; Jemma Hopewell; Mika Kivimaki; Florian Kronenberg; Meena Kumari; Claudia Lamina; KaWah Li; Jutta Palmen; Theodore Papamarkou; Bernhard Paulweber; Jackie Price; Manj Sandhu; Shah Sonia; Tina Shah; Marlene Stewart; Monika Summerer; Philippa J Talmud; Nick Wainwright; Nick Wareham; John Whittaker; Steve E Humphries
Meta analysis of candidate gene variants outside the LPA locus with Lp(a) plasma levels in 14,500 participants of six White European cohorts.
Atherosclerosis 2011;217(2):447-51.
2011: L Nherera; Margaret Thorogood; D Marks; R Minhas; Steve E Humphries
Probabilistic cost-effectiveness analysis of cascade screening for familial hypercholesterolaemia using alternative diagnostic and identification strategies.
Heart (British Cardiac Society) 2011;97(14):1175-81.
2011: Barbara Jefferis; Lucy Lennon; Gordon D O Lowe; Christopher G Owen; Olia Papacosta; Ann Rumley; Andrew Thomson; S Goya Wannamethee; Paul Welsh; Steve E Humphries; Mark Woodward; Peter H Whincup
Interleukin 18 and coronary heart disease: prospective study and systematic review.
Atherosclerosis 2011;217(1):227-33.
2011: Philippa J Talmud; J Whittaker; M Kivimaki; Meena Kumari; Debbie A Lawlor; Jutta Palmen; Shah Sonia; Tina Shah; J P Casas; Jackie A Cooper; Ian N M Day; Fotios Drenos; T Gaunt; Aroon D Hingorani; Michael Holmes; Steve E Humphries
Variants of ADRA2A are associated with fasting glucose, blood pressure, body mass index and type 2 diabetes risk: meta-analysis of four prospective studies.
Diabetologia 2011;54(7):1710-9.
2011: Seamus C Harrison; Michael V Holmes; Obi Agu; Steve E Humphries
Genome wide association studies of abdominal aortic aneurysms-biological insights and potential translation applications.
Atherosclerosis 2011;217(1):47-56.
2011: M C Smart; Philippa J Talmud; M Yannakoulia; Nikos Yiannakouris; J A Cooper; G Dedoussis; G K Dror; M L Grisoni; Steve E Humphries; Meropi Kontogianni; eirini louizou; C S Mantzoros; Labros Melistas; Constantina Papoutsakis
Genetic variation within IL18 is associated with insulin levels, insulin resistance and postprandial measures.
Nutrition, metabolism, and cardiovascular diseases : NMCD 2011;21(7):476-84.
2011: Michael V Holmes; Seamus Harrison; Philippa J Talmud; Aroon D Hingorani; Steve E Humphries
Utility of genetic determinants of lipids and cardiovascular events in assessing risk.
Nature reviews. Cardiology 2011;8(4):207-21.
2011: Saskia C Sanderson; Jo Waller; Steve E Humphries; Jane Wardle
Public awareness of genetic influence on chronic disease risk: are genetic and lifestyle causal beliefs compatible?
Public health genomics 2011;14(4-5):290-7.
2010: Melissa C Smart-Halajko; Marius R Robciuc; Jackie A Cooper; Matti Jauhiainen; Meena Kumari; Mika Kivimaki; Kay-Tee Khaw; S Matthijs Boekholdt; Nicholas J Wareham; Tom R Gaunt; Ian N M Day; Peter S Braund; Christopher P Nelson; Alistair Hall; Nilesh J Samani; Steve E Humphries; Christian Ehnholm; Philippa J Talmud
The relationship between plasma angiopoietin-like protein 4 levels, angiopoietin-like protein 4 genotype, and coronary heart disease risk.
Arteriosclerosis, thrombosis, and vascular biology 2010;30(11):2277-82.
2010: Gie Ken-Dror; Fotios Drenos; Steve E Humphries; Philippa J Talmud; Aroon D Hingorani; M Kivimäki; Meena Kumari; Kenneth A Bauer; James Morrissey; H A Ireland
Haplotype and genotype effects of the F7 gene on circulating factor VII, coagulation activation markers and incident coronary heart disease in UK men.
Journal of thrombosis and haemostasis : JTH 2010;8(11):2394-403.
2010: D A Jones; S L Prior; T S Tang; S C Bain; Steven J Hurel; Steve E Humphries; Jeffrey W Stephens
Association between the rs4880 superoxide dismutase 2 (C>T) gene variant and coronary heart disease in diabetes mellitus.
Diabetes research and clinical practice 2010;90(2):196-201.
2010: Reecha Sofat; Juan P Casas; Meena Kumari; Philippa J Talmud; Helen Ireland; Mika Kivimaki; Michael Marmot; Alun D Hughes; Simon Thom; Shah Ebrahim; John C Whittaker; Liam Smeeth; Debbie A Lawlor; Steve E Humphries; Aroon D Hingorani
Genetic variation in complement factor H and risk of coronary heart disease: eight new studies and a meta-analysis of around 48,000 individuals.
Atherosclerosis 2010;213(1):184-90.
2010: Gie Ken-Dror; Philippa J Talmud; Steve E Humphries; Fotios Drenos
APOE/C1/C4/C2 gene cluster genotypes, haplotypes and lipid levels in prospective coronary heart disease risk among UK healthy men.
Molecular medicine (Cambridge, Mass.) 2010;16(9-10):389-99.
2010: Cécilia G Maubaret; Klelia D Salpea; Anjly Jain; Jackie A Cooper; Anders Hamsten; Julie Sanders; Hugh Montgomery; Andrew Neil; Devaki Nair; Steve E Humphries
Telomeres are shorter in myocardial infarction patients compared to healthy subjects: correlation with environmental risk factors.
Journal of molecular medicine (Berlin, Germany) 2010;88(8):785-94.
2010: H A W Neil; J Cooper; D John Betteridge; N Capps; I F W McDowell; Paul N Durrington; Mary Seed; Jim I Mann; Steve E Humphries
All-cause and cardiovascular mortality in treated patients with severe hypertriglyceridaemia: A long-term prospective registry study.
Atherosclerosis 2010;211(2):618-23.
2010: A G Panayiotou; A N Nicolaides; M Griffin; T Tyllis; N Georgiou; D Bond; R M Martin; D Hoppensteadt; J Fareed; Steve E Humphries
Leukocyte telomere length is associated with measures of subclinical atherosclerosis.
Atherosclerosis 2010;211(1):176-81.
2010: Alison Taylor; D Wang; K Patel; Ros A Whittall; G Wood; M Farrer; R D G Neely; S Fairgrieve; D Nair; M Barbir; J L Jones; S Egan; R Everdale; Y Lolin; E Hughes; J A Cooper; S G Hadfield; Gail Norbury; Steve E Humphries
Mutation detection rate and spectrum in familial hypercholesterolaemia patients in the UK pilot cascade project.
Clinical genetics 2010;77(6):572-80.
2010: Steve E Humphries; Fotios Drenos; Gie Ken-Dror; Philippa J Talmud
Coronary heart disease risk prediction in the era of genome-wide association studies: current status and what the future holds.
Circulation 2010;121(20):2235-48.
2010: Klelia D Salpea; Steve E Humphries
Telomere length in atherosclerosis and diabetes.
Atherosclerosis 2010;209(1):35-8.
2010: Damiano Baldassarre; Kristiina Nyyssönen; Rainer Rauramaa; Ulf de Faire; Anders Hamsten; Andries J Smit; Elmo Mannarino; Steve E Humphries; Philippe Giral; Enzo Grossi; Fabrizio Veglia; Rodolfo Paoletti; Elena Tremoli
Cross-sectional analysis of baseline data to identify the major determinants of carotid intima-media thickness in a European population: the IMPROVE study.
European heart journal 2010;31(5):614-22.
2010: Klelia D Salpea; Philippa J Talmud; Jackie A Cooper; Cecilia G Maubaret; Jeffrey W Stephens; Kavin Abelak; Steve E Humphries
Association of telomere length with type 2 diabetes, oxidative stress and UCP2 gene variation.
Atherosclerosis 2010;209(1):42-50.
2010: Philippa J Talmud; Aroon D Hingorani; Jackie A Cooper; Michael G Marmot; Eric J Brunner; Meena Kumari; Mika Kivimäki; Steve E Humphries
Utility of genetic and non-genetic risk factors in prediction of type 2 diabetes: Whitehall II prospective cohort study.
BMJ (Clinical research ed.) 2010;340():b4838.
2010: Ros A Whittall; Marileia Scartezini; Kawah Li; C Hubbart; Z Reiner; A Abraha; H A W Neil; G Dedoussis; Steve E Humphries
Development of a high-resolution melting method for mutation detection in familial hypercholesterolaemia patients.
Annals of clinical biochemistry 2010;47(Pt 1):44-55.
2010: Jack J Mann; John R Payne; Tina Shah; Dudley J Pennell; Steve E Humphries; Hugh E Montgomery
C-reactive protein gene variant and the human left ventricular growth response to exercise: data from The LARGE Heart Study.
Journal of cardiovascular pharmacology 2010;55(1):26-9.
2010: M C Smart; G Dedoussis; eirini louizou; M Yannakoulia; F Drenos; C Papoutsakis; N Maniatis; Steve E Humphries; Philippa J Talmud
APOE, CETP and LPL genes show strong association with lipid levels in Greek children.
Nutrition, metabolism, and cardiovascular diseases : NMCD 2010;20(1):26-33.
2009: Steve E Humphries; R Dermot G Neely; Ros A Whittall; Jason S Troutt; Robert J Konrad; Marileia Scartezini; Ka Wah Li; Jackie A Cooper; Jayshree Acharya; Andrew Neil
Healthy individuals carrying the PCSK9 p.R46L variant and familial hypercholesterolemia patients carrying PCSK9 p.D374Y exhibit lower plasma concentrations of PCSK9.
Clinical chemistry 2009;55(12):2153-61.
2009: Nadeem Qureshi; Steve E Humphries; Mary Seed; Philip Rowlands; Rubin Minhas
Identification and management of familial hypercholesterolaemia: what does it mean to primary care?
The British journal of general practice : the journal of the Royal College of General Practitioners 2009;59(567):773-6.
2009: Alison Taylor; B Martin; D Wang; K Patel; Steve E Humphries; Gail Norbury
Multiplex ligation-dependent probe amplification analysis to screen for deletions and duplications of the LDLR gene in patients with familial hypercholesterolaemia.
Clinical genetics 2009;76(1):69-75.
2009: Fotios Drenos; Philippa J Talmud; Juan P Casas; Liam Smeeth; Jutta Palmen; Steve E Humphries; Aroon D Hingorani
Integrated associations of genotypes with multiple blood biomarkers linked to coronary heart disease risk.
Human molecular genetics 2009;18(12):2305-16.
2009: Saskia C Sanderson; Meena Kumari; Eric J Brunner; Michelle A Miller; Ann Rumley; Gordon D Lowe; Michael G Marmot; Steve E Humphries
Association between IL6 gene variants -174G>C and -572G>C and serum IL-6 levels: interactions with social position in the Whitehall II cohort.
Atherosclerosis 2009;204(2):459-64.
2009: Sarah L Prior; David R Gable; Jackie A Cooper; Stephen C Bain; Steven J Hurel; Steve E Humphries; Jeffrey W Stephens
Association between the adiponectin promoter rs266729 gene variant and oxidative stress in patients with diabetes mellitus.
European heart journal 2009;30(10):1263-9.
2009: Julie Sanders; Emma Hawe; David Brull; Christina Hubbart; Gordon D O Lowe; Ann Rumley; Steve E Humphries; Hugh E Montgomery
Higher IL-6 levels but not IL6 -174G>C or -572G>C genotype are associated with post-operative complication following coronary artery bypass graft (CABG) surgery.
Atherosclerosis 2009;204(1):196-201.
2009: Anna Kotronen; Hannele Yki-Järvinen; Anna Aminoff; Robert Bergholm; Kirsi H Pietiläinen; Jukka Westerbacka; Philippa J Talmud; Steve E Humphries; Anders Hamsten; Bo Isomaa; Leif Groop; Marju Orho-Melander; Ewa Ehrenborg; Rachel M Fisher
Genetic variation in the ADIPOR2 gene is associated with liver fat content and its surrogate markers in three independent cohorts.
European journal of endocrinology / European Federation of Endocrine Societies 2009;160(4):593-602.
2009: Sarah E A Leigh; Trond P Leren; Steve E Humphries
Commentary PCSK9 variants: A new database.
Atherosclerosis 2009;203(1):32-3.
2009: Andrew R Thompson; Jonathan Golledge; Jackie A Cooper; Hany Hafez; Paul E Norman; Steve E Humphries
Sequence variant on 9p21 is associated with the presence of abdominal aortic aneurysm disease but does not have an impact on aneurysmal expansion.
European journal of human genetics : EJHG 2009;17(3):391-4.
2009: Aroon D Hingorani; Tina Shah; Juan P Casas; Steve E Humphries; Philippa J Talmud
C-reactive protein and coronary heart disease: predictive test or therapeutic target?
Clinical chemistry 2009;55(2):239-55.
2009: Saskia C Sanderson; Jo Waller; Martin J Jarvis; Steve E Humphries; Jane Wardle
Awareness of lifestyle risk factors for cancer and heart disease among adults in the UK.
Patient education and counseling 2009;74(2):221-7.
2009: Andrew J P Smith; Steve E Humphries
Cytokine and cytokine receptor gene polymorphisms and their functionality.
Cytokine & growth factor reviews 2009;20(1):43-59.
2009: Tina Shah; Juan P Casas; Jackie A Cooper; Ioanna Tzoulaki; Reecha Sofat; Valerie McCormack; Liam Smeeth; John E Deanfield; Gordon D Lowe; Ann Rumley; F Gerald R Fowkes; Steve E Humphries; Aroon D Hingorani
Critical appraisal of CRP measurement for the prediction of coronary heart disease events: new data and systematic review of 31 prospective cohorts.
International journal of epidemiology 2009;38(1):217-31.
2009: Klelia D Salpea; David R Gable; Jackie A Cooper; Jeffrey W Stephens; Steven J Hurel; Helen Ireland; Michael D Feher; Ian F Godsland; Steve E Humphries
The effect of WNT5B IVS3C>G on the susceptibility to type 2 diabetes in UK Caucasian subjects.
Nutrition, metabolism, and cardiovascular diseases : NMCD 2009;19(2):140-5.
2009: Andrew J P Smith; Steve E Humphries
Characterization of DNA-binding proteins using multiplexed competitor EMSA.
Journal of molecular biology 2009;385(3):714-7.
2009: Nadeem Qureshi; Sarah Armstrong; Paula Saukko; Tracey H Sach; Jo Middlemass; Phil H Evans; Joe Kai; Hannah Farrimond; Steve E Humphries
Realising the potential of the family history in risk assessment and primary prevention of coronary heart disease in primary care: ADDFAM study protocol.
BMC health services research 2009;9():184.
2009: Andrew Neil; Steve E Humphries
Statins and familial hypercholesterolaemia.
BMJ (Clinical research ed.) 2009;338():a3041.
2009: Luigi Nibali; Francesco D'Aiuto; Nikolaos Donos; Gareth S Griffiths; Mohamed Hussein Parkar; Maurizio S Tonetti; Steve E Humphries; Peter M Brett
Association between periodontitis and common variants in the promoter of the interleukin-6 gene.
Cytokine 2009;45(1):50-4.
2008: Philippa J Talmud; Melissa Smart; Edward Presswood; Jackie A Cooper; Viviane Nicaud; Fotios Drenos; Jutta Palmen; Michael G Marmot; S Matthijs Boekholdt; Nicholas J Wareham; Kay-Tee Khaw; Meena Kumari; Steve E Humphries
ANGPTL4 E40K and T266M: effects on plasma triglyceride and HDL levels, postprandial responses, and CHD risk.
Arteriosclerosis, thrombosis, and vascular biology 2008;28(12):2319-25.
2008: Adrian Plunkett; Rachel Agbeko; Kawah Li; Steve E Humphries; Nigel J Klein; Mark J Peters
Angiotensin-converting enzyme D allele does not influence susceptibility to acute hypoxic respiratory failure in children.
Intensive care medicine 2008;34(12):2279-83.
2008: Andrew Neil; Jackie Cooper; John Betteridge; Nigel Capps; Ian McDowell; Paul Durrington; Mary Seed; Steve E Humphries
Reductions in all-cause, cancer, and coronary mortality in statin-treated patients with heterozygous familial hypercholesterolaemia: a prospective registry study.
European heart journal 2008;29(21):2625-33.
2008: Bilge Ozsait; Evrim Kömürcü Bayrak; Mehves Poda; günay can; Gülay Hergenç; Altan Onat; Steve E Humphries; Nihan Erginel-Unaltuna
CETP TaqIB polymorphism in Turkish adults: association with dyslipidemia and metabolic syndrome.
Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology 2008;8(5):324-30.
2008: B Dorfmeister; W W Zeng; A Dichlberger; S K Nilsson; F G Schaap; J A Hubacek; Martin Merkel; Jackie A Cooper; A Lookene; Wendy Putt; R Whittall; P J Lee; laurence lins; N Delsaux; M Nierman; J A Kuivenhoven; J J P Kastelein; M Vrablik; Gunilla Olivecrona; W J Schneider; J Heeren; Steve E Humphries; Philippa J Talmud
Effects of six APOA5 variants, identified in patients with severe hypertriglyceridemia, on in vitro lipoprotein lipase activity and receptor binding.
Arteriosclerosis, thrombosis, and vascular biology 2008;28(10):1866-71.
2008: Jeffrey W Stephens; Stephen C Bain; Steve E Humphries
Gene-environment interaction and oxidative stress in cardiovascular disease.
Atherosclerosis 2008;200(2):229-38.
2008: Robert S Elkeles; Ian F Godsland; MD Feher; Michael B Rubens; Michael Roughton; Fiona Nugara; Steve E Humphries; Williams Richmond; Marcus Flather
Coronary calcium measurement improves prediction of cardiovascular events in asymptomatic patients with type 2 diabetes: the PREDICT study.
European heart journal 2008;29(18):2244-51.
2008: Eric Brunner; Mika Kivimäki; Daniel R Witte; Debbie A Lawlor; George Davey Smith; Jackie A Cooper; Michelle Miller; Gordon D O Lowe; Ann Rumley; Juan P Casas; Tina Shah; Steve E Humphries; Aroon D Hingorani; Michael G Marmot; Nicholas J Timpson; Meena Kumari
Inflammation, insulin resistance, and diabetes--Mendelian randomization using CRP haplotypes points upstream.
PLoS medicine 2008;5(8):e155.
2008: Steve E Humphries; C norbury; Sarah Leigh; S Gaye Hadfield; Devikair Nair
What is the clinical utility of DNA testing in patients with familial hypercholesterolaemia?
Current opinion in lipidology 2008;19(4):362-8.
2008: Klelia D Salpea; Viviane Nicaud; Laurence Tiret; Philippa J Talmud; Steve E Humphries
The association of telomere length with paternal history of premature myocardial infarction in the European Atherosclerosis Research Study II.
Journal of molecular medicine (Berlin, Germany) 2008;86(7):815-24.
2008: Jutta Palmen; Andrew J P Smith; Birgit Dorfmeister; Wendy Putt; Steve E Humphries; Philippa J Talmud
The functional interaction on in vitro gene expression of APOA5 SNPs, defining haplotype APOA52, and their paradoxical association with plasma triglyceride but not plasma apoAV levels.
Biochimica et biophysica acta 2008;1782(7-8):447-52.
2008: Steve E Humphries
The pain is that we will have to increase the rejection rate, from its current 60-65% to nearer 75-80%.
Atherosclerosis 2008;199(1):1-2.
2008: S E A Leigh; A H Foster; Ros A Whittall; C S Hubbart; Steve E Humphries
Update and analysis of the University College London low density lipoprotein receptor familial hypercholesterolemia database.
Annals of human genetics 2008;72(Pt 4):485-98.
2008: Steve E Humphries; Gaye Hadfield
Identifying patients with familial hypercholesterolaemia in primary care.
Heart (British Cardiac Society) 2008;94(6):695-6.
2008: Saskia C Sanderson; Steve E Humphries; Christina Hubbart; Eluned Hughes; Martin J Jarvis; Jane Wardle
Psychological and behavioural impact of genetic testing smokers for lung cancer risk: a phase II exploratory trial.
Journal of health psychology 2008;13(4):481-94.
2008: J M Samuel; Daniel Kelberman; A J P Smith; Steve E Humphries; Patricia Woo
Identification of a novel regulatory region in the interleukin-6 gene promoter.
Cytokine 2008;42(2):256-64.
2008: Andrew J P Smith; Francesco D'Aiuto; Jutta Palmen; Jackie A Cooper; Jane Samuel; Simon G Thompson; Julie Sanders; Nikolaos Donos; Luigi Nibali; David Brull; Pat Woo; Steve E Humphries
Association of serum interleukin-6 concentration with a functional IL6 -6331T>C polymorphism.
Clinical chemistry 2008;54(5):841-50.
2008: Claudio Verzilli; Tina Shah; Juan P Casas; Juliet Chapman; Manjinder Sandhu; Sally L Debenham; Matthijs S Boekholdt; Kay-Tee Khaw; Nicholas J Wareham; Richard Judson; Emelia Benjamin; Sekar Kathiresan; Martin G Larson; Jian Rong; Reecha Sofat; Steve E Humphries; Liam Smeeth; Gianpiero Cavalleri; John C Whittaker; Aroon D Hingorani
Bayesian meta-analysis of genetic association studies with different sets of markers.
American journal of human genetics 2008;82(4):859-72.
2008: Steve E Humphries; Nikos Yiannakouris; Philippa J Talmud
Cardiovascular disease risk prediction using genetic information (gene scores): is it really informative?
Current opinion in lipidology 2008;19(2):128-32.
2008: Philippa J Talmud; Jackie A Cooper; Jutta Palmen; Ruth Lovering; Fotios Drenos; Aroon D Hingorani; Steve E Humphries
Chromosome 9p21.3 coronary heart disease locus genotype and prospective risk of CHD in healthy middle-aged men.
Clinical chemistry 2008;54(3):467-74.
2008: Nicholas S Hopkinson; Ka Wah Li; Anthony Kehoe; Steve E Humphries; Michael Roughton; John Moxham; Hugh Montgomery; Michael I Polkey
Vitamin D receptor genotypes influence quadriceps strength in chronic obstructive pulmonary disease.
The American journal of clinical nutrition 2008;87(2):385-90.
2008: Saskia C Sanderson; Jane Wardle; Steve E Humphries
Public health genomics and genetic test evaluation: the challenge of conducting behavioural research on the utility of lifestyle-genetic tests.
Journal of nutrigenetics and nutrigenomics 2008;1(5):224-31.
2008: Anthony S Wierzbicki; Steve E Humphries; Rubin Minhas
Familial hypercholesterolaemia: summary of NICE guidance.
BMJ (Clinical research ed.) 2008;337():a1095.
2008: Mika Kivimäki; Debbie A Lawlor; George Davey Smith; Meena Kumari; Ann Donald; Annie Britton; Juan P Casas; Tina Shah; Eric Brunner; Nicholas J Timpson; julian halcox; Michelle A Miller; Steve E Humphries; John Deanfield; Michael G Marmot; Aroon D Hingorani
Does high C-reactive protein concentration increase atherosclerosis? The Whitehall II Study.
PloS one 2008;3(8):e3013.
2008: Ali Reza Hosseini-Khalili; Julian Thompson; Anthony Kehoe; Nicholas S Hopkinson; A Khoshbaten; mohammadreza soroush; Steve E Humphries; Hugh Montgomery; Mostafa Ghanei
Angiotensin-converting enzyme genotype and late respiratory complications of mustard gas exposure.
BMC pulmonary medicine 2008;8():15.
2008: Brian Starr; S Gaye Hadfield; Barbara A Hutten; Peter J Lansberg; Trond P Leren; Dorte Damgaard; H Andrew W Neil; Steve E Humphries
Development of sensitive and specific age- and gender-specific low-density lipoprotein cholesterol cutoffs for diagnosis of first-degree relatives with familial hypercholesterolaemia in cascade testing.
Clinical chemistry and laboratory medicine : CCLM / FESCC 2008;46(6):791-803.
2008: Evrim Komurcu-Bayrak; Altan Onat; Mehves Poda; Steve E Humphries; Jutta Palmen; Filiz Guclu; günay can; Nihan Erginel-Unaltuna
Gender-modulated impact of apolipoprotein A5 gene (APOA5) -1131T>C and c.56C>G polymorphisms on lipids, dyslipidemia and metabolic syndrome in Turkish adults.
Clinical chemistry and laboratory medicine : CCLM / FESCC 2008;46(6):778-84.
2008: Amal Muthumala; Fotios Drenos; Perry M Elliott; Steve E Humphries
Role of beta adrenergic receptor polymorphisms in heart failure: systematic review and meta-analysis.
European journal of heart failure 2008;10(1):3-13.
2008: A R Thompson; F Drenos; H Hafez; Steve E Humphries
Candidate gene association studies in abdominal aortic aneurysm disease: a review and meta-analysis.
European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery 2008;35(1):19-30.
2008: Jeffrey W Stephens; Sukhbir S Dhamrait; Ali R Mani; Jayshree Acharya; Kevin Moore; Steven J Hurel; Steve E Humphries
Interaction between the uncoupling protein 2 -866G>A gene variant and cigarette smoking to increase oxidative stress in subjects with diabetes.
Nutrition, metabolism, and cardiovascular diseases : NMCD 2008;18(1):7-14.
2007: Simon G Thompson; Pamela A McCaskie; John P Beilby; Joseph Hung; Michelle Jennens; Caroline Chapman; Peter Thompson; Steve E Humphries
IL18 haplotypes are associated with serum IL-18 concentrations in a population-based study and a cohort of individuals with premature coronary heart disease.
Clinical chemistry 2007;53(12):2078-85.
2007: Simon R Thompson; Daniela Novick; Carmel J Stock; Julie Sanders; David Brull; Jackie Cooper; Patricia Woo; George Miller; Menachem Rubinstein; Steve E Humphries
Free Interleukin (IL)-18 levels, and the impact of IL18 and IL18BP genetic variation, in CHD patients and healthy men.
Arteriosclerosis, thrombosis, and vascular biology 2007;27(12):2743-9.
2007: Amal Muthumala; David R Gable; Jutta Palmen; Jackie A Cooper; Jeffrey W Stephens; George J Miller; Steve E Humphries
Is the influence of variation in the ACE gene on the prospective risk of Type 2 diabetes in middle-aged men modified by obesity?
Clinical science (London, England : 1979) 2007;113(12):467-72.
2007: Marileia Scartezini; Christina Hubbart; Ros A Whittall; Jackie A Cooper; Andrew H W Neil; Steve E Humphries
The PCSK9 gene R46L variant is associated with lower plasma lipid levels and cardiovascular risk in healthy U.K. men.
Clinical science (London, England : 1979) 2007;113(11):435-41.
2007: Andrew J P Smith; Fayha Ahmed; Devi Nair; Ros A Whittall; Darrell Wang; Alison Taylor; Gail Norbury; Steve E Humphries
A functional mutation in the LDLR promoter (-139C>G) in a patient with familial hypercholesterolemia.
European journal of human genetics : EJHG 2007;15(11):1186-9.
2007: Gaye S Hadfield; Steve E Humphries
Familial hypercholesterolaemia: Cascade testing is tried and tested and cost effective.
BMJ (Clinical research ed.) 2007;335(7622):683.
2007: Ruth Hall; Paula M Saukko; Philip H Evans; Nadeem Qureshi; Steve E Humphries
Assessing family history of heart disease in primary care consultations: a qualitative study.
Family practice 2007;24(5):435-42.
2007: Pierre Morange; Noémie Saut; Marie-Christine Alessi; John S Yudkin; Maurizio Margaglione; Giovanni Di Minno; Anders Hamsten; Steve E Humphries; David-Alexandre Tregouet; Irène Juhan-Vague
Association of plasminogen activator inhibitor (PAI)-1 (SERPINE1) SNPs with myocardial infarction, plasma PAI-1, and metabolic parameters: the HIFMECH study.
Arteriosclerosis, thrombosis, and vascular biology 2007;27(10):2250-7.
2007: Fotios Drenos; J C Whittaker; Steve E Humphries
The use of meta-analysis risk estimates for candidate genes in combination to predict coronary heart disease risk.
Annals of human genetics 2007;71(Pt 5):611-9.
2007: John R Payne; Lindsay E James; Kyriacos I Eleftheriou; Emma Hawe; Jack Mann; Alex Stronge; Karen Banham; Michael J World; Steve E Humphries; Dudley J Pennell; Hugh E Montgomery
The association of left ventricular mass with blood pressure, cigarette smoking and alcohol consumption; data from the LARGE Heart study.
International journal of cardiology 2007;120(1):52-8.
2007: Amal Muthumala; Hugh Montgomery; Jutta Palmen; Jackie A Cooper; Steve E Humphries
Angiotensin-converting enzyme genotype interacts with systolic blood pressure to determine coronary heart disease risk in healthy middle-aged men.
Hypertension 2007;50(2):348-53.
2007: Evrim Komurcu-Bayrak; Altan Onat; Mehves Poda; Steve E Humphries; Jayshree Acharya; Gülay Hergenc; Neslihan Coban; günay can; Nihan Erginel-Unaltuna
The S447X variant of lipoprotein lipase gene is associated with metabolic syndrome and lipid levels among Turks.
Clinica chimica acta; international journal of clinical chemistry 2007;383(1-2):110-5.
2007: David R Gable; J Matin; Ros A Whittall; H Cakmak; Ka Wah Li; Jackie Cooper; George J Miller; Steve E Humphries
Common adiponectin gene variants show different effects on risk of cardiovascular disease and type 2 diabetes in European subjects.
Annals of human genetics 2007;71(Pt 4):453-66.
2007: Peter T E Wootton; Nupur L Arora; Fotios Drenos; Simon R Thompson; Jackie A Cooper; Jeffrey W Stephens; Steven J Hurel; Eva Hurt-Camejo; Olov Wiklund; Steve E Humphries; Philippa J Talmud
Tagging SNP haplotype analysis of the secretory PLA2-V gene, PLA2G5, shows strong association with LDL and oxLDL levels, suggesting functional distinction from sPLA2-IIA: results from the UDACS study.
Human molecular genetics 2007;16(12):1437-44.
2007: Alison Taylor; S Tabrah; D Wang; M Sozen; N Duxbury; Ros A Whittall; Steve E Humphries; Gail Norbury
Multiplex ARMS analysis to detect 13 common mutations in familial hypercholesterolaemia.
Clinical genetics 2007;71(6):561-8.
2007: Philippa J Talmud; David M Flavell; Khaled Alfakih; Jackie A Cooper; Anthony J Balmforth; Mohan U Sivananthan; Hugh E Montgomery; Alistair Hall; Steve E Humphries
The lipoprotein lipase gene serine 447 stop variant influences hypertension-induced left ventricular hypertrophy and risk of coronary heart disease.
Clinical science (London, England : 1979) 2007;112(12):617-24.
2007: Wai-Man R Wong; Andrew B Gerry; Wendy Putt; Jane L Roberts; Richard B Weinberg; Steve E Humphries; David S Leake; Philippa J Talmud
Common variants of apolipoprotein A-IV differ in their ability to inhibit low density lipoprotein oxidation.
Atherosclerosis 2007;192(2):266-74.
2007: Simon R Thompson; Julie Sanders; Jeffrey W Stephens; George J Miller; Steve E Humphries
A common interleukin 18 haplotype is associated with higher body mass index in subjects with diabetes and coronary heart disease.
Metabolism: clinical and experimental 2007;56(5):662-9.
2007: Jeffrey W Stephens; Steven J Hurel; Gordon D O Lowe; Ann Rumley; Steve E Humphries
Association between plasma IL-6, the IL6 -174G>C gene variant and the metabolic syndrome in type 2 diabetes mellitus.
Molecular genetics and metabolism 2007;90(4):422-8.
2007: Daljit K Hothi; Paul Bass; Mary Morgan; Jayshree Acharya; Steve E Humphries; Rodney David Gilbert
Acute renal failure in a patient with paroxysmal cold hemoglobinuria.
Pediatric nephrology (Berlin, Germany) 2007;22(4):593-6.
2007: Birgit Dorfmeister; Jackie A Cooper; Jeffrey W Stephens; Helen Ireland; Steven J Hurel; Steve E Humphries; Philippa J Talmud
The effect of APOA5 and APOC3 variants on lipid parameters in European Whites, Indian Asians and Afro-Caribbeans with type 2 diabetes.
Biochimica et biophysica acta 2007;1772(3):355-63.
2007: P C Hindmarsh; C H Rodeck; Steve E Humphries
Polymorphisms in the angiotensin converting enzyme gene and growth in the first year of life.
Annals of human genetics 2007;71(Pt 2):176-84.
2007: David Harding; Steve E Humphries; Andrew Whitelaw; Neil Marlow; Hugh E Montgomery
Cognitive outcome and cyclo-oxygenase-2 gene (-765 G/C) variation in the preterm infant.
Archives of disease in childhood. Fetal and neonatal edition 2007;92(2):F108-12.
2007: Alireza Shamaei-Tousi; Andrew Steptoe; Katie O'Donnell; Jutta Palmen; Jeffrey W Stephens; Steven J Hurel; Michael Marmot; Karen Homer; Francesco D'Aiuto; Anthony R M Coates; Steve E Humphries; Brian Henderson
Plasma heat shock protein 60 and cardiovascular disease risk: the role of psychosocial, genetic, and biological factors.
Cell stress & chaperones 2007;12(4):384-92.
2007: David R Gable; Saskia C Sanderson; Steve E Humphries
Genotypes, obesity and type 2 diabetes--can genetic information motivate weight loss? A review.
Clinical chemistry and laboratory medicine : CCLM / FESCC 2007;45(3):301-8.
2007: John R Payne; Sukhbir S Dhamrait; Peter Gohlke; Jackie Cooper; R A Scott; Yannis P Pitsiladis; Steve E Humphries; B Rayner; Hugh E Montgomery
The impact of ACE genotype on serum ACE activity in a black South African male population.
Annals of human genetics 2007;71(Pt 1):1-7.
2007: Peter T E Wootton; David M Flavell; Hugh E Montgomery; Michael J World; Steve E Humphries; Philippa J Talmud
Lipoprotein-associated phospholipase A2 A379V variant is associated with body composition changes in response to exercise training.
Nutrition, metabolism, and cardiovascular diseases : NMCD 2007;17(1):24-31.
2007: Steve E Humphries; Jackie A Cooper; Philippa J Talmud; George J Miller
Candidate gene genotypes, along with conventional risk factor assessment, improve estimation of coronary heart disease risk in healthy UK men.
Clinical chemistry 2007;53(1):8-16.
2007: Fotios Drenos; George J Miller; Steve E Humphries
Increase of plasma fibrinogen levels and variability with age in a sample of middle aged healthy men.
Annals of human genetics 2007;71(Pt 1):43-53.
2006: Steve E Humphries; David R Gable; Jackie A Cooper; Helen Ireland; Jeffrey W Stephens; Steven J Hurel; Ka Wah Li; Jutta Palmen; Michelle A Miller; Francesco P Cappuccio; Robert Elkeles; Ian Godsland; George J Miller; Philippa J Talmud
Common variants in the TCF7L2 gene and predisposition to type 2 diabetes in UK European Whites, Indian Asians and Afro-Caribbean men and women.
Journal of molecular medicine (Berlin, Germany) 2006;84(12):1005-14.
2006: Julie Sanders; Joanna Harris; Jackie Cooper; Peter Gohlke; Steve E Humphries; Hugh Montgomery; David R Woods
Lack of change in serum angiotensin-converting enzyme activity during the menstrual cycle.
Journal of the renin-angiotensin-aldosterone system : JRAAS 2006;7(4):231-5.
2006: John R Payne; Kyriacos I Eleftheriou; Lindsay E James; Emma Hawe; J Mann; A Stronge; P Kotwinski; Michael J World; Steve E Humphries; Dudley J Pennell; Hugh E Montgomery
Left ventricular growth response to exercise and cigarette smoking: data from LARGE Heart.
Heart (British Cardiac Society) 2006;92(12):1784-8.
2006: Amal Muthumala; Jackie Cooper; Steve E Humphries
European differences in the association between ACE I/D polymorphism and incidence of MI may be explained by gene-lipid interaction.
Atherosclerosis 2006;189(2):474-7.
2006: Juan P Casas; Gianpiero L Cavalleri; Leonelo E Bautista; Liam Smeeth; Steve E Humphries; Aroon D Hingorani
Endothelial nitric oxide synthase gene polymorphisms and cardiovascular disease: a HuGE review.
American journal of epidemiology 2006;164(10):921-35.
2006: José Ricardo S Vieira; Ros A Whittall; Jackie A Cooper; George J Miller; Steve E Humphries
The A370T variant (StuI polymorphism) in the LDL receptor gene is not associated with plasma lipid levels or cardiovascular risk in UK men.
Annals of human genetics 2006;70(Pt 6):697-704.
2006: Peter T E Wootton; Jeffrey W Stephens; Steven J Hurel; Hervé Durand; Jackie Cooper; Ewa Ninio; Steve E Humphries; Philippa J Talmud
Lp-PLA2 activity and PLA2G7 A379V genotype in patients with diabetes mellitus.
Atherosclerosis 2006;189(1):149-56.
2006: Philippa J Talmud; Jackie A Cooper; H Hattori; I P Miller; George J Miller; Steve E Humphries
The apolipoprotein A-V genotype and plasma apolipoprotein A-V and triglyceride levels: prospective risk of type 2 diabetes. Results from the Northwick Park Heart Study II.
Diabetologia 2006;49(10):2337-40.
2006: David R Gable; Steven J Hurel; Steve E Humphries
Adiponectin and its gene variants as risk factors for insulin resistance, the metabolic syndrome and cardiovascular disease.
Atherosclerosis 2006;188(2):231-44.
2006: Jeffrey W Stephens; Sukhbir S Dhamrait; Jayshree Acharya; Steve E Humphries; Steven J Hurel
A common variant in the ACE gene is associated with peripheral neuropathy in women with type 2 diabetes mellitus.
Journal of diabetes and its complications 2006;20(5):317-21.
2006: Stefan F C Vaessen; Frank G Schaap; Jan Albert Kuivenhoven; Albert K Groen; Barbara A Hutten; S Matthijs Boekholdt; Hiroaki Hattori; Manjinder S Sandhu; Sheila A Bingham; Robert Luben; Jutta A Palmen; Nicholas J Wareham; Steve E Humphries; John J P Kastelein; Philippa J Talmud; Kay-Tee Khaw
Apolipoprotein A-V, triglycerides and risk of coronary artery disease: the prospective Epic-Norfolk Population Study.
Journal of lipid research 2006;47(9):2064-70.
2006: Tom W Meade; Steve E Humphries; Bianca L De Stavola
Commentary: fibrinogen and coronary heart disease--test of causality by 'Mendelian' randomization by Keavney et al.
International journal of epidemiology 2006;35(4):944-7.
2006: Juan P Casas; Tina Shah; Jackie Cooper; Emma Hawe; Alex D McMahon; Dairena Gaffney; Chris J Packard; Denis S O'Reilly; Irène Juhan-Vague; John S Yudkin; Elena Tremoli; Maurizio Margaglione; Giovanni Di Minno; Anders Hamsten; Teake Kooistra; Jeffrey W Stephens; Steven J Hurel; Shona J Livingstone; Helen M Colhoun; George J Miller; Leonelo E Bautista; Tom Meade; Naveed Sattar; Steve E Humphries; Aroon D Hingorani
Insight into the nature of the CRP-coronary event association using Mendelian randomization.
International journal of epidemiology 2006;35(4):922-31.
2006: Wendy Aitken; Alex Chisholm; Ashley W Duncan; Michelle J Harper; Steve E Humphries; Jim I Mann; C Murray Skeaff; Wayne H F Sutherland; Alison J Wallace; Sheila M Williams
Variation in the cholesteryl ester transfer protein (CETP) gene does not influence individual plasma cholesterol response to changes in the nature of dietary fat.
Nutrition, metabolism, and cardiovascular diseases : NMCD 2006;16(5):353-63.
2006: Alireza Shamaei-Tousi; Jeffrey W Stephens; Ren Bin; Jacqueline A Cooper; Andrew Steptoe; Anthony R M Coates; Brian Henderson; Steve E Humphries
Association between plasma levels of heat shock protein 60 and cardiovascular disease in patients with diabetes mellitus.
European heart journal 2006;27(13):1565-70.
2006: David R Gable; Jeffrey W Stephens; Jackie A Cooper; George J Miller; Steve E Humphries
Variation in the UCP2-UCP3 gene cluster predicts the development of type 2 diabetes in healthy middle-aged men.
Diabetes 2006;55(5):1504-11.
2006: Amanda M Shearman; Jackie A Cooper; Paul J Kotwinski; George J Miller; Steve E Humphries; Kristin G Ardlie; Barbara Jordan; Kathryn Irenze; Kathryn L Lunetta; Stephanie C E Schuit; André G Uitterlinden; Huibert A P Pols; Serkalem Demissie; L Adrienne Cupples; Michael Mendelsohn; Daniel Levy; David E Housman
Estrogen receptor alpha gene variation is associated with risk of myocardial infarction in more than seven thousand men from five cohorts.
Circulation research 2006;98(5):590-2.
2006: Juan P Casas; Jackie Cooper; George J Miller; Aroon D Hingorani; Steve E Humphries
Investigating the genetic determinants of cardiovascular disease using candidate genes and meta-analysis of association studies.
Annals of human genetics 2006;70(Pt 2):145-69.
2006: Steve E Humphries; Treena Cranston; Marcus Allen; Helen Middleton-Price; Maryam C Fernandez; Victoria Senior; Emma Hawe; Andrew Iversen; Richard Wray; Martin Crook; Anthony S Wierzbicki
Mutational analysis in UK patients with a clinical diagnosis of familial hypercholesterolaemia: relationship with plasma lipid traits, heart disease risk and utility in relative tracing.
Journal of molecular medicine (Berlin, Germany) 2006;84(3):203-14.
2006: Jeffrey W Stephens; David R Gable; Steven J Hurel; George J Miller; Jackie A Cooper; Steve E Humphries
Increased plasma markers of oxidative stress are associated with coronary heart disease in males with diabetes mellitus and with 10-year risk in a prospective sample of males.
Clinical chemistry 2006;52(3):446-52.
2006: David M Flavell; Peter T E Wootton; Saul G Myerson; Michael J World; Dudley J Pennell; Steve E Humphries; Philippa J Talmud; Hugh E Montgomery
Variation in the lipoprotein lipase gene influences exercise-induced left ventricular growth.
Journal of molecular medicine (Berlin, Germany) 2006;84(2):126-31.
2006: Steve E Humphries; Aroon Hingorani
Pharmacogenetics: progress, pitfalls and clinical potential for coronary heart disease.
Vascular pharmacology 2006;44(2):119-25.
2006: Tony Hayek; Jeffrey W Stephens; Christina S Hubbart; Jayshree Acharya; Muriel J Caslake; Emma Hawe; George J Miller; Steven J Hurel; Steve E Humphries
A common variant in the glutathione S transferase gene is associated with elevated markers of inflammation and lipid peroxidation in subjects with diabetes mellitus.
Atherosclerosis 2006;184(2):404-12.
2006: Peter T E Wootton; Fotios Drenos; Jackie A Cooper; Simon R Thompson; Jeffrey W Stephens; Eva Hurt-Camejo; Olov Wiklund; Steve E Humphries; Philippa J Talmud
Tagging-SNP haplotype analysis of the secretory PLA2IIa gene PLA2G2A shows strong association with serum levels of sPLA2IIa: results from the UDACS study.
Human molecular genetics 2006;15(2):355-61.
2005: Helen Ireland; Constantine J Konstantoulas; Jackie A Cooper; Emma Hawe; Steve E Humphries; Hugh Mather; Alison H Goodall; J Hogwood; Irène Juhan-Vague; John S Yudkin; Giovanni Di Minno; Maurizio Margaglione; Anders Hamsten; George J Miller; K A Bauer; Y T Kim; Deborah J Stearns-Kurosawa; Shinichiro Kurosawa
EPCR Ser219Gly: elevated sEPCR, prothrombin F1+2, risk for coronary heart disease, and increased sEPCR shedding in vitro.
Atherosclerosis 2005;183(2):283-92.
2005: Philippa J Talmud; Jeffrey W Stephens; Emma Hawe; S Demissie; L A Cupples; Steven J Hurel; Steve E Humphries; Jose Ordovas
The significant increase in cardiovascular disease risk in APOEepsilon4 carriers is evident only in men who smoke: potential relationship between reduced antioxidant status and ApoE4.
Annals of human genetics 2005;69(Pt 6):613-22.
2005: Amanda M Shearman; Jackie A Cooper; Paul J Kotwinski; Steve E Humphries; Michael Mendelsohn; David E Housman; George J Miller
Estrogen receptor alpha gene variation and the risk of stroke.
Stroke; a journal of cerebral circulation 2005;36(10):2281-2.
2005: Ping Li; Mohamed A Elrayess; Abuzeid H Gomma; Jutta Palmen; Emma Hawe; Kim M Fox; Steve E Humphries
The microsatellite polymorphism of heme oxygenase-1 is associated with baseline plasma IL-6 level but not with restenosis after coronary in-stenting.
Chinese medical journal 2005;118(18):1525-32.
2005: Philippa J Talmud; Jutta Palmen; Wendy Putt; laurence lins; Steve E Humphries
Determination of the functionality of common APOA5 polymorphisms.
The Journal of biological chemistry 2005;280(31):28215-20.
2005: S Gaye Hadfield; Steve E Humphries
Implementation of cascade testing for the detection of familial hypercholesterolaemia.
Current opinion in lipidology 2005;16(4):428-33.
2005: David Harding; David Brull; Steve E Humphries; Andrew Whitelaw; Hugh Montgomery; Neil Marlow
Variation in the interleukin-6 gene is associated with impaired cognitive development in children born prematurely: a preliminary study.
Pediatric research 2005;58(1):117-20.
2005: Jackie A Cooper; George J Miller; Steve E Humphries
A comparison of the PROCAM and Framingham point-scoring systems for estimation of individual risk of coronary heart disease in the Second Northwick Park Heart Study.
Atherosclerosis 2005;181(1):93-100.
2005: Dawn M Waterworth; Hans Jansen; Viviane Nicaud; Steve E Humphries; Philippa J Talmud
Interaction between insulin (VNTR) and hepatic lipase (LIPC-514C>T) variants on the response to an oral glucose tolerance test in the EARSII group of young healthy men.
Biochimica et biophysica acta 2005;1740(3):375-81.
2005: Jenan Younis; Jackie A Cooper; George J Miller; Steve E Humphries; Philippa J Talmud
Genetic variation in alcohol dehydrogenase 1C and the beneficial effect of alcohol intake on coronary heart disease risk in the Second Northwick Park Heart Study.
Atherosclerosis 2005;180(2):225-32.
2005: Mark S Fife; Emma M Ogilvie; Daniel Kelberman; J Samuel; A Gutierrez; Steve E Humphries; Patricia Woo
Novel IL-6 haplotypes and disease association.
Genes and immunity 2005;6(4):367-70.
2005: M Mert Sözen; Ros A Whittall; Cihan Oner; Aysegul Tokatli; H Serap Kalkanoğlu; Ali Dursun; Turgay Coşkun; Reyhan Oner; Steve E Humphries
The molecular basis of familial hypercholesterolaemia in Turkish patients.
Atherosclerosis 2005;180(1):63-71.
2005: Francesco D'Aiuto; Juan P Casas; Tina Shah; Steve E Humphries; Aroon D Hingorani; Maurizio S Tonetti
C-reactive protein (+1444C>T) polymorphism influences CRP response following a moderate inflammatory stimulus.
Atherosclerosis 2005;179(2):413-7.
2005: Pierre Morange; Noémie Saut; Marie-Christine Alessi; Corinne Frere; Emma Hawe; John S Yudkin; Elena Tremoli; Maurizio Margaglione; Giovanni Di Minno; Anders Hamsten; Steve E Humphries; Irène Juhan-Vague
Interaction between the C-260T polymorphism of the CD14 gene and the plasma IL-6 concentration on the risk of myocardial infarction: the HIFMECH study.
Atherosclerosis 2005;179(2):317-23.
2005: Laleh Morgan; Steve E Humphries
The genetics of stroke.
Current opinion in lipidology 2005;16(2):193-9.
2005: Ainsley J Newson; Steve E Humphries
Cascade testing in familial hypercholesterolaemia: how should family members be contacted?
European journal of human genetics : EJHG 2005;13(4):401-8.
2005: Margita Eriksson-Berg; Hiroyuki Deguchi; Emma Hawe; Daniela Scanavini; Kristina Orth-Gomér; Karin Schenck-Gustafsson; Steve E Humphries; Angela Silveira; Anders Hamsten
Influence of factor VII gene polymorphisms and environmental factors on plasma coagulation factor VII concentrations in middle-aged women with and without manifest coronary heart disease.
Thrombosis and haemostasis 2005;93(2):351-8.
2005: David M Flavell; Helen Ireland; Jeffrey W Stephens; Emma Hawe; Jayshree Acharya; Hugh Mather; Steven J Hurel; Steve E Humphries
Peroxisome proliferator-activated receptor alpha gene variation influences age of onset and progression of type 2 diabetes.
Diabetes 2005;54(2):582-6.
2005: Jeffrey W Stephens; Sukhbir S Dhamrait; Jaqueline A Cooper; Jayshree Acharya; George J Miller; Steven J Hurel; Steve E Humphries
The D allele of the ACE I/D common gene variant is associated with Type 2 diabetes mellitus in Caucasian subjects.
Molecular genetics and metabolism 2005;84(1):83-9.
2005: Jeffrey W Stephens; M Mert Sozen; Ros A Whittall; Muriel J Caslake; Dorothy Bedford; Jayshree Acharya; Steven J Hurel; Steve E Humphries
Three novel mutations in the apolipoprotein E gene in a sample of individuals with type 2 diabetes mellitus.
Clinical chemistry 2005;51(1):119-24.
2004: Christelle Foucher; Stephanie Rattier; David M Flavell; Philippa J Talmud; Steve E Humphries; John J P Kastelein; Amir Ayyobi; Simon Pimstone; Jiri Frohlich; Jean-Claude Ansquer; George Steiner
Response to micronized fenofibrate treatment is associated with the peroxisome-proliferator-activated receptors alpha G/C intron7 polymorphism in subjects with type 2 diabetes.
Pharmacogenetics 2004;14(12):823-9.
2004: Jeffrey W Stephens; Gareth Ambler; Patrick Vallance; D John Betteridge; Steve E Humphries; Steven J Hurel
Cardiovascular risk and diabetes. Are the methods of risk prediction satisfactory?
European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology 2004;11(6):521-8.
2004: Mert Sozen; Ros A Whittall; Steve E Humphries
Mutation detection in patients with familial hypercholesterolaemia using heteroduplex and single strand conformation polymorphism analysis by capillary electrophoresis.
Atherosclerosis. Supplements 2004;5(5):7-11.
2004: Helen Ireland; George J Miller; Karen E Webb; Jackie A Cooper; Steve E Humphries
The factor VII activating protease G511E (Marburg) variant and cardiovascular risk.
Thrombosis and haemostasis 2004;92(5):986-92.
2004: Mohamed A Elrayess; Karen E Webb; Geoff J Bellingan; Ros A Whittall; Jahangir Kabir; Emma Hawe; Mikko Syvänne; Marja-Riitta Taskinen; M Heikki Frick; Markku S Nieminen; Y Antero Kesäniemi; Amos Pasternack; George J Miller; Steve E Humphries
R643G polymorphism in PECAM-1 influences transendothelial migration of monocytes and is associated with progression of CHD and CHD events.
Atherosclerosis 2004;177(1):127-35.
2004: Philippa J Talmud; Sarah J Lewis; Emma Hawe; Steve Martin; Jayshree Acharya; Michael Marmot; Steve E Humphries; Eric Brunner
No APOEepsilon4 effect on coronary heart disease risk in a cohort with low smoking prevalence: the Whitehall II study.
Atherosclerosis 2004;177(1):105-12.
2004: Constantine J Konstantoulas; Jackie Cooper; G Warnock; George J Miller; Steve E Humphries; Helen Ireland
A combination of two common thrombomodulin gene variants (-1208-1209TTdelTT and A455V) influence risk of coronary heart disease: a prospective study in men.
Atherosclerosis 2004;177(1):97-104.
2004: David Harding; Sukhbir S Dhamrait; Andrew Whitelaw; Steve E Humphries; Neil Marlow; Hugh E Montgomery
Does interleukin-6 genotype influence cerebral injury or developmental progress after preterm birth?
Pediatrics 2004;114(4):941-7.
2004: Carolyn M Hutter; Melissa A Austin; Steve E Humphries
Familial hypercholesterolemia, peripheral arterial disease, and stroke: a HuGE minireview.
American journal of epidemiology 2004;160(5):430-5.
2004: Melissa A Austin; Carolyn M Hutter; Ron L Zimmern; Steve E Humphries
Familial hypercholesterolemia and coronary heart disease: a HuGE association review.
American journal of epidemiology 2004;160(5):421-9.
2004: Melissa A Austin; Carolyn M Hutter; Ron L Zimmern; Steve E Humphries
Genetic causes of monogenic heterozygous familial hypercholesterolemia: a HuGE prevalence review.
American journal of epidemiology 2004;160(5):407-20.
2004: Saskia C Sanderson; Jane Wardle; Martin J Jarvis; Steve E Humphries
Public interest in genetic testing for susceptibility to heart disease and cancer: a population-based survey in the UK.
Preventive medicine 2004;39(3):458-64.
2004: Wai-Man R Wong; Jeffrey W Stephens; Jayshree Acharya; Steven J Hurel; Steve E Humphries; Philippa J Talmud
The APOA4 T347S variant is associated with reduced plasma TAOS in subjects with diabetes mellitus and cardiovascular disease.
Journal of lipid research 2004;45(8):1565-71.
2004: Wendy Putt; Jutta Palmen; Viviane Nicaud; David-Alexandre Tregouet; Nadia Tahri-Daizadeh; David M Flavell; Steve E Humphries; Philippa J Talmud
Variation in USF1 shows haplotype effects, gene : gene and gene : environment associations with glucose and lipid parameters in the European Atherosclerosis Research Study II.
Human molecular genetics 2004;13(15):1587-97.
2004: Theresa M Marteau; Victoria Senior; Steve E Humphries; Martin Bobrow; Treena Cranston; Martin Crook; Lorna Day; Maryam Fernandez; Robert Horne; Andrew Iversen; Zoe Jackson; Jacqui Lynas; Helen Middleton-Price; Richard Savine; Jim Sikorski; Melanie Watson; John Weinman; Anthony S Wierzbicki; Richard Wray
Psychological impact of genetic testing for familial hypercholesterolemia within a previously aware population: a randomized controlled trial.
American journal of medical genetics. Part A 2004;128A(3):285-93.
2004: John S Yudkin; Irène Juhan-Vague; Emma Hawe; Steve E Humphries; Giovanni Di Minno; Maurizio Margaglione; Elena Tremoli; Teake Kooistra; P E Morange; Pia Lundman; Vidya Mohamed-Ali; Anders Hamsten
Low-grade inflammation may play a role in the etiology of the metabolic syndrome in patients with coronary heart disease: the HIFMECH study.
Metabolism: clinical and experimental 2004;53(7):852-7.
2004: Jeffrey W Stephens; Steven J Hurel; Jacqueline A Cooper; Jayshree Acharya; George J Miller; Steve E Humphries
A common functional variant in the interleukin-6 gene is associated with increased body mass index in subjects with type 2 diabetes mellitus.
Molecular genetics and metabolism 2004;82(2):180-6.
2004: L James; G Onambele; RC Woledge; D Skelton; D Woods; Kyriacos I Eleftheriou; Emma Hawe; Steve E Humphries; F Haddad; Hugh Montgomery
IL-6-174G/C genotype is associated with the bone mineral density response to oestrogen replacement therapy in post-menopausal women.
European journal of applied physiology 2004;92(1-2):227-30.
2004: Melissa A Austin; C Zhang; Steve E Humphries; W L Chandler; Philippa J Talmud; Karen L Edwards; Donna L Leonetti; Marguerite J McNeely; Wilfred Y Fujimoto
Heritability of C-reactive protein and association with apolipoprotein E genotypes in Japanese Americans.
Annals of human genetics 2004;68(Pt 3):179-88.
2004: John R Payne; Sukhbir S Dhamrait; Iqbal S Toor; Jackie Cooper; Alun Jones; George J Miller; Steve E Humphries; Hugh E Montgomery
The -344T>C promoter variant of the gene for aldosterone synthase (CYP11B2) is not associated with cardiovascular risk in a prospective study of UK healthy men.
Atherosclerosis 2004;174(1):81-6.
2004: Thomas Sanders; Tamara de Grassi; Jayshree Acharya; George J Miller; Steve E Humphries
Postprandial variations in fibrinolytic activity in middle-aged men are modulated by plasminogen activator inhibitor I 4G-675/5G genotype but not by the fat content of a meal.
The American journal of clinical nutrition 2004;79(4):577-81.
2004: Hannah E Theobald; Philip J Chowienczyk; Ros Whittall; Steve E Humphries; Thomas Sanders
LDL cholesterol-raising effect of low-dose docosahexaenoic acid in middle-aged men and women.
The American journal of clinical nutrition 2004;79(4):558-63.
2004: Melissa A Austin; Karen L Edwards; Marguerite J McNeely; Wayne L Chandler; Donna L Leonetti; Philippa J Talmud; Steve E Humphries; Wilfred Y Fujimoto
Heritability of multivariate factors of the metabolic syndrome in nondiabetic Japanese americans.
Diabetes 2004;53(4):1166-9.
2004: Steve E Humphries; Laleh Morgan
Genetic risk factors for stroke and carotid atherosclerosis: insights into pathophysiology from candidate gene approaches.
Lancet neurology 2004;3(4):227-35.
2004: Philippa J Talmud; Steve Martin; Marja-Riitta Taskinen; M Heikki Frick; Markku S Nieminen; Y Antero Kesäniemi; Amos Pasternack; Steve E Humphries; Mikko Syvänne
APOA5 gene variants, lipoprotein particle distribution, and progression of coronary heart disease: results from the LOCAT study.
Journal of lipid research 2004;45(4):750-6.
2004: Steve E Humphries; Paul M Ridker; Philippa J Talmud
Genetic testing for cardiovascular disease susceptibility: a useful clinical management tool or possible misinformation?
Arteriosclerosis, thrombosis, and vascular biology 2004;24(4):628-36.
2004: Juan P Casas; Leonelo E Bautista; Steve E Humphries; Aroon D Hingorani
Endothelial nitric oxide synthase genotype and ischemic heart disease: meta-analysis of 26 studies involving 23028 subjects.
Circulation 2004;109(11):1359-65.
2004: Daniel Kelberman; Mark S Fife; Matthew V Rockman; David Brull; Patricia Woo; Steve E Humphries
Analysis of common IL-6 promoter SNP variants and the AnTn tract in humans and primates and effects on plasma IL-6 levels following coronary artery bypass graft surgery.
Biochimica et biophysica acta 2004;1688(2):160-7.
2004: Sukhbir S Dhamrait; Jeffrey W Stephens; Jacqueline A Cooper; Jayshree Acharya; Ali R Mani; Kevin Moore; George J Miller; Steve E Humphries; Steven J Hurel; Hugh E Montgomery
Cardiovascular risk in healthy men and markers of oxidative stress in diabetic men are associated with common variation in the gene for uncoupling protein 2.
European heart journal 2004;25(6):468-75.
2004: Jeffrey W Stephens; Steven J Hurel; Jayshree Acharya; Steve E Humphries
An interaction between the interleukin-6 -174G>C gene variant and urinary protein excretion influences plasma oxidative stress in subjects with type 2 diabetes.
Cardiovascular diabetology 2004;3():2.
2004: Constantine J Konstantoulas; Emma Hawe; Noémie Saut; John S Yudkin; Giovanni Di Minno; Maurizio Margaglione; Anders Hamsten; Steve E Humphries; Irène Juhan-Vague; Helen Ireland
Common variants in the thrombomodulin gene as a risk for myocardial infarction in the north of Europe (HIFMECH Study).
Thrombosis and haemostasis 2004;91(3):628-30.
2004: Alun G Williams; Sukhbir S Dhamrait; Peter T E Wootton; Stephen H Day; Emma Hawe; John R Payne; Saul G Myerson; Michael J World; Richard Budgett; Steve E Humphries; Hugh E Montgomery
Bradykinin receptor gene variant and human physical performance.
Journal of applied physiology (Bethesda, Md. : 1985) 2004;96(3):938-42.
2004: David Woods; Julie Sanders; Alun Jones; Emma Hawe; Peter Gohlke; Steve E Humphries; John Payne; Hugh Montgomery
The serum angiotensin-converting enzyme and angiotensin II response to altered posture and acute exercise, and the influence of ACE genotype.
European journal of applied physiology 2004;91(2-3):342-8.
2004: Chris Hendriksz; Gail Norbury; S Tabrah; Alison Taylor; Steve E Humphries
Homozygous hypercholesterolaemia and ezetimibe: a case report.
Acta paediatrica (Oslo, Norway : 1992) 2004;93(2):280-2.
2004: Mikko Syvänne; Ros A Whittall; Ursula Turpeinen; Markku S Nieminen; M Heikki Frick; Y Antero Kesäniemi; Amos Pasternack; Steve E Humphries; Marja-Riitta Taskinen
Serum homocysteine concentrations, gemfibrozil treatment, and progression of coronary atherosclerosis.
Atherosclerosis 2004;172(2):267-72.
2004: Melissa A Austin; Philippa J Talmud; Federico M Farin; Deborah A Nickerson; Karen L Edwards; Donna L Leonetti; Marguerite J McNeely; Hannah-Malia A Viernes; Steve E Humphries; Wilfred Y Fujimoto
Association of apolipoprotein A5 variants with LDL particle size and triglyceride in Japanese Americans.
Biochimica et biophysica acta 2004;1688(1):1-9.
2004: Philippa J Talmud; Steve E Humphries
Gene: environment interactions and coronary heart disease risk.
World review of nutrition and dietetics 2004;93():29-40.
2003: Kirsty S Robertson; Emma Hawe; George J Miller; Philippa J Talmud; Steve E Humphries
Human paraoxonase gene cluster polymorphisms as predictors of coronary heart disease risk in the prospective Northwick Park Heart Study II.
Biochimica et biophysica acta 2003;1639(3):203-12.
2003: Irène Juhan-Vague; Pierre Morange; Corinne Frere; Marie-Françoise Aillaud; Marie-Christine Alessi; Emma Hawe; Susanna Boquist; P Tornvall; John S Yudkin; Elena Tremoli; Maurizio Margaglione; Giovanni Di Minno; Anders Hamsten; Steve E Humphries
The plasminogen activator inhibitor-1 -675 4G/5G genotype influences the risk of myocardial infarction associated with elevated plasma proinsulin and insulin concentrations in men from Europe: the HIFMECH study.
Journal of thrombosis and haemostasis : JTH 2003;1(11):2322-9.
2003: David Brull; Norma C Serrano; F Zito; Lisa Jones; Hugh E Montgomery; Ann Rumley; Pankaj Sharma; Gordon D O Lowe; Michael J World; Steve E Humphries; A D Hingorani
Human CRP gene polymorphism influences CRP levels: implications for the prediction and pathogenesis of coronary heart disease.
Arteriosclerosis, thrombosis, and vascular biology 2003;23(11):2063-9.
2003: Alun Jones; Sukhbir S Dhamrait; John R Payne; Emma Hawe; Ping Li; Iqbal S Toor; Le Luong; Peter T E Wootton; George J Miller; Steve E Humphries; Hugh E Montgomery
Genetic variants of angiotensin II receptors and cardiovascular risk in hypertension.
Hypertension 2003;42(4):500-6.
2003: Sukhbir S Dhamrait; John R Payne; Ping Li; Alun Jones; Iqbal S Toor; Jacqueline A Cooper; Emma Hawe; Jutta Palmen; Peter T E Wootton; George J Miller; Steve E Humphries; Hugh E Montgomery
Variation in bradykinin receptor genes increases the cardiovascular risk associated with hypertension.
European heart journal 2003;24(18):1672-80.
2003: Caroline M L Chapman; John P Beilby; Steve E Humphries; Lyle Palmer; Peter L Thompson; Joseph Hung
Association of an allelic variant of interleukin-6 with subclinical carotid atherosclerosis in an Australian community population.
European heart journal 2003;24(16):1494-9.
2003: Steve E Humphries
The stromelysin-1 (MMP-3) gene and risk of coronary artery disease: a candidate gene that has won the election?
Thrombosis and haemostasis 2003;90(1):3-6.
2003: Karen E Webb; John F Martin; James Cotton; Jorge D Erusalimsky; Steve E Humphries
The 4830C>A polymorphism within intron 5 affects the pattern of alternative splicing occurring within exon 6 of the thrombopoietin gene.
Experimental hematology 2003;31(6):488-94.
2003: Jaroslav A Hubacek; Jan Pitha; Zdena Skodová; Rudolf Poledne; Vera Lánská; Dawn M Waterworth; Steve E Humphries; Philippa J Talmud
Polymorphisms in CYP-7A1, not APOE, influence the change in plasma lipids in response to population dietary change in an 8 year follow-up; results from the Czech MONICA study.
Clinical biochemistry 2003;36(4):263-7.
2003: Arshia Panahloo; Vidya Mohamed-Ali; Rosaire P Gray; Steve E Humphries; John S Yudkin
Plasminogen activator inhibitor-1 (PAI-1) activity post myocardial infarction: the role of acute phase reactants, insulin-like molecules and promoter (4G/5G) polymorphism in the PAI-1 gene.
Atherosclerosis 2003;168(2):297-304.
2003: A M Abuzeid; Emma Hawe; Steve E Humphries; Philippa J Talmud
Association between the Ala379Val variant of the lipoprotein associated phospholipase A2 and risk of myocardial infarction in the north and south of Europe.
Atherosclerosis 2003;168(2):283-8.
2003: Steve E Humphries; Emma Hawe; Sukhbir S Dhamrait; George J Miller; Philippa J Talmud
In search of genetic precision.
Lancet 2003;361(9372):1908-9; author reply 1909-10.
2003: Wai-Man R Wong; Emma Hawe; Lai K Li; George J Miller; Viviane Nicaud; Len A Pennacchio; Steve E Humphries; Philippa J Talmud
Apolipoprotein AIV gene variant S347 is associated with increased risk of coronary heart disease and lower plasma apolipoprotein AIV levels.
Circulation research 2003;92(9):969-75.
2003: Mohamed A Elrayess; Karen E Webb; David M Flavell; Mikko Syvänne; Marja-Riitta Taskinen; M Heikki Frick; Markku S Nieminen; Y Antero Kesäniemi; Amos Pasternack; J Wouter Jukema; John J P Kastelein; Aeilko H Zwinderman; Steve E Humphries
A novel functional polymorphism in the PECAM-1 gene (53G>A) is associated with progression of atherosclerosis in the LOCAT and REGRESS studies.
Atherosclerosis 2003;168(1):131-8.
2003: Dalya Marks; Margaret Thorogood; H A W Neil; Steve E Humphries
A review on the diagnosis, natural history, and treatment of familial hypercholesterolaemia.
Atherosclerosis 2003;168(1):1-14.
2003: Steve Martin; Viviane Nicaud; Steve E Humphries; Philippa J Talmud
Contribution of APOA5 gene variants to plasma triglyceride determination and to the response to both fat and glucose tolerance challenges.
Biochimica et biophysica acta 2003;1637(3):217-25.
2003: Dawn M Waterworth; Philippa J Talmud; J Luan; David M Flavell; C D Byrne; Steve E Humphries; N J Wareham
Variants in the APOC3 promoter insulin responsive element modulate insulin secretion and lipids in middle-aged men.
Biochimica et biophysica acta 2003;1637(3):200-6.
2003: Philippa J Talmud; Steve Martin; George Steiner; David M Flavell; David Whitehouse; Sylvia Nagl; Richard Jackson; Marja-Riitta Taskinen; M Heikki Frick; Markku S Nieminen; Y Antero Kesäniemi; Amos Pasternack; Steve E Humphries; Mikko Syvänne
Progression of atherosclerosis is associated with variation in the alpha1-antitrypsin gene.
Arteriosclerosis, thrombosis, and vascular biology 2003;23(4):644-9.
2003: Emma Hawe; Philippa J Talmud; George J Miller; Steve E Humphries
Family history is a coronary heart disease risk factor in the Second Northwick Park Heart Study.
Annals of human genetics 2003;67(Pt 2):97-106.
2003: Dalya Marks; Margaret Thorogood; H A W Neil; David Wonderling; Steve E Humphries
Comparing costs and benefits over a 10 year period of strategies for familial hypercholesterolaemia screening.
Journal of public health medicine 2003;25(1):47-52.
2003: Raymond S Camilleri; Ian J Mackie; Steve E Humphries; Samuel J Machin; Hannah Cohen
Lack of association of beta2-glycoprotein I polymorphisms Val247Leu and Trp316Ser with antiphospholipid antibodies in patients with thrombosis and pregnancy complications.
British journal of haematology 2003;120(6):1066-72.
2003: James M Cotton; Ying Hong; Emma Hawe; Anthony Mathur; Steve E Humphries; Angie S Brown; John F Martin; Jorge D Erusalimsky
Rise of circulating thrombopoietin following cardiothoracic surgery is potentiated in patients with coronary atherosclerosis: correlation with a preceding increase in levels of interleukin-6.
Thrombosis and haemostasis 2003;89(3):538-43.
2003: Jeffrey W Stephens; Steve E Humphries
The molecular genetics of cardiovascular disease: clinical implications.
Journal of internal medicine 2003;253(2):120-7.
2003: Rachel M Fisher; Ferdaous Benhizia; Renate Schreiber; Elena Makoveichuk; Wendy Putt; Maysoon Al-Haideri; Richard J Deckelbaum; Gunilla Olivecrona; Steve E Humphries; Philippa J Talmud
Enhanced bridging function and augmented monocyte adhesion by lipoprotein lipase N9: insights into increased risk of coronary artery disease in N9 carriers.
Atherosclerosis 2003;166(2):243-51.
2002: Nancy Swords Jenny; Russell P Tracy; Malcolm S Ogg; Le Ahn Luong; Lewis H Kuller; Alice M Arnold; ALBERT SHARRETT; Steve E Humphries
In the elderly, interleukin-6 plasma levels and the -174G>C polymorphism are associated with the development of cardiovascular disease.
Arteriosclerosis, thrombosis, and vascular biology 2002;22(12):2066-71.
2002: Abuzeid H Gomma; Mohamed A Elrayess; CJ Knight; Emma Hawe; Kim M Fox; Steve E Humphries
The endothelial nitric oxide synthase (Glu298Asp and -786T>C) gene polymorphisms are associated with coronary in-stent restenosis.
European heart journal 2002;23(24):1955-62.
2002: Philippa J Talmud; Emma Hawe; Steve Martin; Michael Olivier; George J Miller; Edward M Rubin; Len A Pennacchio; Steve E Humphries
Relative contribution of variation within the APOC3/A4/A5 gene cluster in determining plasma triglycerides.
Human molecular genetics 2002;11(24):3039-46.
2002: Steve E Humphries; S Martin; Jackie Cooper; G Miller
Interaction between smoking and the stromelysin-1 (MMP3) gene 5A/6A promoter polymorphism and risk of coronary heart disease in healthy men.
Annals of human genetics 2002;66(Pt 5-6):343-52.
2002: Philippa J Talmud; Emma Hawe; George J Miller; Steve E Humphries
Nonfasting apolipoprotein B and triglyceride levels as a useful predictor of coronary heart disease risk in middle-aged UK men.
Arteriosclerosis, thrombosis, and vascular biology 2002;22(11):1918-23.
2002: Francesco Zito; Gordon D O Lowe; Ann Rumley; Alex D McMahon; Steve E Humphries
Association of the factor XII 46C>T polymorphism with risk of coronary heart disease (CHD) in the WOSCOPS study.
Atherosclerosis 2002;165(1):153-8.
2002: Anastasia Papafili; Mike R Hill; David Brull; Robin J McAnulty; Richard P Marshall; Steve E Humphries; Geoffrey J Laurent
Common promoter variant in cyclooxygenase-2 represses gene expression: evidence of role in acute-phase inflammatory response.
Arteriosclerosis, thrombosis, and vascular biology 2002;22(10):1631-6.
2002: Ros A Whittall; S Matheus; Treena Cranston; George J Miller; Steve E Humphries
The intron 14 2140+5G>A variant in the low density lipoprotein receptor gene has no effect on plasma cholesterol levels.
Journal of medical genetics 2002;39(9):e57.
2002: Richard P Marshall; Suzanne Webb; Geoff Bellingan; Hugh E Montgomery; Babar Chaudhari; Robin J McAnulty; Steve E Humphries; Mike R Hill; Geoffrey J Laurent
Angiotensin converting enzyme insertion/deletion polymorphism is associated with susceptibility and outcome in acute respiratory distress syndrome.
American journal of respiratory and critical care medicine 2002;166(5):646-50.
2002: David R Woods; Andrew J Pollard; David J Collier; Yalda Jamshidi; Vassilis Vassiliou; Emma Hawe; Steve E Humphries; Hugh E Montgomery
Insertion/deletion polymorphism of the angiotensin I-converting enzyme gene and arterial oxygen saturation at high altitude.
American journal of respiratory and critical care medicine 2002;166(3):362-6.
2002: Helen M Colhoun; Francesco Zito; N Norman Chan; Michael B Rubens; John H Fuller; Steve E Humphries
Activated factor XII levels and factor XII 46C>T genotype in relation to coronary artery calcification in patients with type 1 diabetes and healthy subjects.
Atherosclerosis 2002;163(2):363-9.
2002: Melissa A Austin; Ron L Zimmern; Steve E Humphries
High "population attributable fraction" for coronary heart disease mortality among relatives in monogenic familial hypercholesterolemia.
Genetics in medicine : official journal of the American College of Medical Genetics 2002;4(4):275-8.
2002: Yalda Jamshidi; David M Flavell; Emma Hawe; Peter K MacCallum; Tom W Meade; Steve E Humphries
Genetic determinants of the response to bezafibrate treatment in the lower extremity arterial disease event reduction (LEADER) trial.
Atherosclerosis 2002;163(1):183-92.
2002: C P M Leeson; Aroon D Hingorani; Michael J Mullen; N Jeerooburkhan; Mia Kattenhorn; Tim J Cole; D P R Muller; Alan Lucas; Steve E Humphries; John E Deanfield
Glu298Asp endothelial nitric oxide synthase gene polymorphism interacts with environmental and dietary factors to influence endothelial function.
Circulation research 2002;90(11):1153-8.
2002: Dalya Marks; David Wonderling; Margaret Thorogood; Helen Lambert; Steve E Humphries; H A W Neil
Cost effectiveness analysis of different approaches of screening for familial hypercholesterolaemia.
BMJ (Clinical research ed.) 2002;324(7349):1303.
2002: Irène Juhan-Vague; Pierre Morange; H Aubert; M Henry; Marie-Françoise Aillaud; Marie-Christine Alessi; A Samnegård; Emma Hawe; John S Yudkin; Maurizio Margaglione; Giovanni Di Minno; Anders Hamsten; Steve E Humphries
Plasma thrombin-activatable fibrinolysis inhibitor antigen concentration and genotype in relation to myocardial infarction in the north and south of Europe.
Arteriosclerosis, thrombosis, and vascular biology 2002;22(5):867-73.
2002: Tatjana Rundek; Mitchell S V Elkind; John Pittman; Bernadette Boden-Albala; Steve Martin; Steve E Humphries; Suh-Hang Hank Juo; Ralph L Sacco
Carotid intima-media thickness is associated with allelic variants of stromelysin-1, interleukin-6, and hepatic lipase genes: the Northern Manhattan Prospective Cohort Study.
Stroke; a journal of cerebral circulation 2002;33(5):1420-3.
2002: Steve E Humphries; C Bauters; A Meirhaeghe; Le Luong; M Bertrand; P Amouyel
The 5A6A polymorphism in the promoter of the stromelysin-1 (MMP3) gene as a risk factor for restenosis.
European heart journal 2002;23(9):721-5.
2002: David Harding; Paul Baines; David Brull; Vassilis Vassiliou; Ian Ellis; Anthony Hart; A P J Thomson; Steve E Humphries; Hugh E Montgomery
Severity of meningococcal disease in children and the angiotensin-converting enzyme insertion/deletion polymorphism.
American journal of respiratory and critical care medicine 2002;165(8):1103-6.
2002: Federica Basso; Gordon D O Lowe; Ann Rumley; Alex D McMahon; Steve E Humphries
Interleukin-6 -174G>C polymorphism and risk of coronary heart disease in West of Scotland coronary prevention study (WOSCOPS).
Arteriosclerosis, thrombosis, and vascular biology 2002;22(4):599-604.
2002: Philippa J Talmud; Steve E Humphries
Gene:environment interaction in lipid metabolism and effect on coronary heart disease risk.
Current opinion in lipidology 2002;13(2):149-54.
2002: David M Flavell; Yalda Jamshidi; Emma Hawe; Inés Pineda Torra; Marja-Riitta Taskinen; M Heikki Frick; Markku S Nieminen; Y Antero Kesäniemi; Amos Pasternack; Bart Staels; George Miller; Steve E Humphries; Philippa J Talmud; Mikko Syvänne
Peroxisome proliferator-activated receptor alpha gene variants influence progression of coronary atherosclerosis and risk of coronary artery disease.
Circulation 2002;105(12):1440-5.
2002: Philippa J Talmud; Emma Hawe; K Robertson; George J Miller; N E Miller; Steve E Humphries
Genetic and environmental determinants of plasma high density lipoprotein cholesterol and apolipoprotein AI concentrations in healthy middle-aged men.
Annals of human genetics 2002;66(Pt 2):111-24.
2002: David Brull; C P M Leeson; Hugh E Montgomery; Michael J Mullen; M deDivitiis; Steve E Humphries; John E Deanfield; C P M Lesson
The effect of the Interleukin-6-174G > C promoter gene polymorphism on endothelial function in healthy volunteers.
European journal of clinical investigation 2002;32(3):153-7.
2002: Richard P Marshall; Suzanne Webb; Mike R Hill; Steve E Humphries; Geoffrey J Laurent
Genetic polymorphisms associated with susceptibility and outcome in ARDS.
Chest 2002;121(3 Suppl):68S-69S.
2002: David Brull; Julie Sanders; Ann Rumley; Gordon D O Lowe; Steve E Humphries; Hugh E Montgomery
Impact of angiotensin converting enzyme inhibition on post-coronary artery bypass interleukin 6 release.
Heart (British Cardiac Society) 2002;87(3):252-5.
2002: Yalda Jamshidi; Hugh E Montgomery; Hans-Werner Hense; Saul G Myerson; Inés Pineda Torra; Bart Staels; Michael J World; Angela Doering; Jeanette Erdmann; Christian Hengstenberg; Steve E Humphries; Heribert Schunkert; David M Flavell
Peroxisome proliferator--activated receptor alpha gene regulates left ventricular growth in response to exercise and hypertension.
Circulation 2002;105(8):950-5.
2002: David R Woods; Michael J World; Mark P Rayson; Alun G Williams; Mick Jubb; Yalda Jamshidi; M Hayward; David A S G Mary; Steve E Humphries; Hugh E Montgomery
Endurance enhancement related to the human angiotensin I-converting enzyme I-D polymorphism is not due to differences in the cardiorespiratory response to training.
European journal of applied physiology 2002;86(3):240-4.
2002: Steve E Humphries; Maria Benedetta Donati
Analysis of gene-environment interaction in coronary artery disease.
Italian heart journal : official journal of the Italian Federation of Cardiology 2002;3(1):3-5.
2002: Hugh Montgomery; David Brull; Steve E Humphries
Analysis of gene-environment interactions by "stressing-the-genotype" studies: the angiotensin converting enzyme and exercise-induced left ventricular hypertrophy as an example.
Italian heart journal : official journal of the Italian Federation of Cardiology 2002;3(1):10-4.
2001: Vidya Mohamed-Ali; Louise Flower; Jaswinder Sethi; G Hotamisligil; Rosaire Gray; Steve E Humphries; D A York; Jonathan Pinkney
beta-Adrenergic regulation of IL-6 release from adipose tissue: in vivo and in vitro studies.
The Journal of clinical endocrinology and metabolism 2001;86(12):5864-9.
2001: Steve E Humphries; Le Luong; M S Ogg; Emma Hawe; George J Miller
The interleukin-6 -174 G/C promoter polymorphism is associated with risk of coronary heart disease and systolic blood pressure in healthy men.
European heart journal 2001;22(24):2243-52.
2001: N Jeerooburkhan; LC Jones; SR Bujac; Jackie A Cooper; George J Miller; Patrick Vallance; Steve E Humphries; Aroon D Hingorani
Genetic and environmental determinants of plasma nitrogen oxides and risk of ischemic heart disease.
Hypertension 2001;38(5):1054-61.
2001: David Brull; Liam J Murray; Colin A Boreham; S H Ralston; Hugh E Montgomery; Alison M Gallagher; F E McGuigan; George Davey Smith; kofoworola savage; Steve E Humphries; Ian S Young
Effect of a COL1A1 Sp1 binding site polymorphism on arterial pulse wave velocity: an index of compliance.
Hypertension 2001;38(3):444-8.
2001: David Brull; Hugh E Montgomery; Julie Sanders; Sukhbir S Dhamrait; Le Luong; Ann Rumley; Gordon D O Lowe; Steve E Humphries
Interleukin-6 gene -174g>c and -572g>c promoter polymorphisms are strong predictors of plasma interleukin-6 levels after coronary artery bypass surgery.
Arteriosclerosis, thrombosis, and vascular biology 2001;21(9):1458-63.
2001: Philippa J Talmud; Lars Berglund; Emma Hawe; Dawn M Waterworth; Carmen R Isasi; R E Deckelbaum; Thomas J Starc; Henry N Ginsberg; Steve E Humphries; Steven Shea
Age-related effects of genetic variation on lipid levels: The Columbia University BioMarkers Study.
Pediatrics 2001;108(3):E50.
2001: David Brull; Julie Sanders; Ann Rumley; Gordon D O Lowe; Steve E Humphries; Hugh E Montgomery
Statin therapy and the acute inflammatory response after coronary artery bypass grafting.
The American journal of cardiology 2001;88(4):431-3.
2001: Philippa J Talmud; Steve E Humphries
Genetic polymorphisms, lipoproteins and coronary artery disease risk.
Current opinion in lipidology 2001;12(4):405-9.
2001: Steve E Humphries; Philippa J Talmud; Emma Hawe; M Bolla; Ian N M Day; George J Miller
Apolipoprotein E4 and coronary heart disease in middle-aged men who smoke: a prospective study.
Lancet 2001;358(9276):115-9.
2001: D Woods; G Onambele; RC Woledge; D Skelton; S Bruce; Steve E Humphries; Hugh Montgomery
Angiotensin-I converting enzyme genotype-dependent benefit from hormone replacement therapy in isometric muscle strength and bone mineral density.
The Journal of clinical endocrinology and metabolism 2001;86(5):2200-4.
2001: F Benhizia; Henry N Ginsberg; Steve E Humphries; Philippa J Talmud
Variation in the human ApoB signal peptide modulates ApoB17 translocation.
Biochemical and biophysical research communications 2001;283(1):149-57.
2001: Derek G Cook; F P Cappuccio; Richard W Atkinson; PD Wicks; A Chitolie; E R Nakandakare; Giuseppe A Sagnella; Steve E Humphries
Ethnic differences in fibrinogen levels: the role of environmental factors and the beta-fibrinogen gene.
American journal of epidemiology 2001;153(8):799-806.
2001: K E Heath; Steve E Humphries; Helen Middleton-Price; M Boxer
A molecular genetic service for diagnosing individuals with familial hypercholesterolaemia (FH) in the United Kingdom.
European journal of human genetics : EJHG 2001;9(4):244-52.
2001: D Woods; M Hickman; Yalda Jamshidi; David Brull; Vassilis Vassiliou; A Jones; Steve E Humphries; Hugh Montgomery
Elite swimmers and the D allele of the ACE I/D polymorphism.
Human genetics 2001;108(3):230-2.
2001: Jaroslav A Hubacek; Dawn M Waterworth; Rudolf Poledne; Jan Pitha; Zdena Skodová; Steve E Humphries; Philippa J Talmud
Genetic determination of plasma lipids and insulin in the Czech population.
Clinical biochemistry 2001;34(2):113-8.
2001: Liz Steed; Robert S Kong; Jan Stygall; Jayshree Acharya; M Bolla; Michael J G Harrison; Steve E Humphries; Stanton P Newman
The role of apolipoprotein E in cognitive decline after cardiac operation.
The Annals of thoracic surgery 2001;71(3):823-6.
2001: K E Webb; J F Martin; A Hamsten; P Eriksson; Licia Iacoviello; Marinella Gattone; M B Donati; Augusto Di Castelnuovo; Jorge D Erusalimsky; Steve E Humphries
Polymorphisms in the thrombopoietin gene are associated with risk of myocardial infarction at a young age.
Atherosclerosis 2001;154(3):703-11.
2001: V Dekou; Peter H Whincup; Olia Papacosta; Shah Ebrahim; Lucy Lennon; Per Magne Ueland; H Refsum; Steve E Humphries; Vilmundur Gudnason
The effect of the C677T and A1298C polymorphisms in the methylenetetrahydrofolate reductase gene on homocysteine levels in elderly men and women from the British regional heart study.
Atherosclerosis 2001;154(3):659-66.
2001: Dawn M Waterworth; Philippa J Talmud; Steve E Humphries; PD Wicks; Giuseppe A Sagnella; Pasquale Strazzullo; K G Alberti; Derek G Cook; Francesco P Cappuccio
Variable effects of the APOC3-482C > T variant on insulin, glucose and triglyceride concentrations in different ethnic groups.
Diabetologia 2001;44(2):245-8.
2001: Saul G Myerson; Hugh E Montgomery; M Whittingham; Mick Jubb; Michael J World; Steve E Humphries; Dudley J Pennell
Left ventricular hypertrophy with exercise and ACE gene insertion/deletion polymorphism: a randomized controlled trial with losartan.
Circulation 2001;103(2):226-30.
2001: Jaroslav A Hubácek; Dawn M Waterworth; Jan Pitha; Steve E Humphries; Philippa J Talmud; Rudolf Poledne
Polymorphisms in the lipoprotein lipase and hepatic lipase genes and plasma lipid values in the Czech population.
Physiological research / Academia Scientiarum Bohemoslovaca 2001;50(4):345-51.
2001: Steve E Humphries; Hugh E Montgomery; Philippa J Talmud
Predisposing genes, high-risk environments and coronary artery disease: LPL and fibrinogen as examples.
World review of nutrition and dietetics 2001;89():61-7.
2001: Philippa J Talmud; D M Waterworth; Steve E Humphries
Effect of genetic variation on the postprandial response. Results from the European Atherosclerosis Research Study II.
World review of nutrition and dietetics 2001;89():53-60.
2001: V Dekou; Vilmundur Gudnason; Emma Hawe; George J Miller; David Stansbie; Steve E Humphries
Gene-environment and gene-gene interaction in the determination of plasma homocysteine levels in healthy middle-aged men.
Thrombosis and haemostasis 2001;85(1):67-74.
2001: KE Heath; M Gahan; Ros A Whittall; Steve E Humphries
Low-density lipoprotein receptor gene (LDLR) world-wide website in familial hypercholesterolaemia: update, new features and mutation analysis.
Atherosclerosis 2001;154(1):243-6.
2000: Dawn M Waterworth; Philippa J Talmud; SR Bujac; RM Fisher; George J Miller; Steve E Humphries
Contribution of apolipoprotein C-III gene variants to determination of triglyceride levels and interaction with smoking in middle-aged men.
Arteriosclerosis, thrombosis, and vascular biology 2000;20(12):2663-9.
2000: David R Woods; Steve E Humphries; Hugh E Montgomery
The ACE I/D polymorphism and human physical performance.
Trends in endocrinology and metabolism: TEM 2000;11(10):416-20.
2000: H Liu; Christine Labeur; C F Xu; R Ferrell; laurence lins; Robert Brasseur; Maryvonne Rosseneu; K M Weiss; Steve E Humphries; Philippa J Talmud
Characterization of the lipid-binding properties and lipoprotein lipase inhibition of a novel apolipoprotein C-III variant Ala23Thr.
Journal of lipid research 2000;41(11):1760-71.
2000: Louise Flower; R H Ahuja; Steve E Humphries; Vidya Mohamed-Ali
Effects of sample handling on the stability of interleukin 6, tumour necrosis factor-alpha and leptin.
Cytokine 2000;12(11):1712-6.
2000: Francesco Zito; FJ Drummond; SR Bujac; M P Esnouf; James Morrissey; Steve E Humphries; George J Miller
Epidemiological and genetic associations of activated factor XII concentration with factor VII activity, fibrinopeptide A concentration, and risk of coronary heart disease in men.
Circulation 2000;102(17):2058-62.
2000: Alison J Wallace; Jim I Mann; Wayne H F Sutherland; Sheila Williams; Alex Chisholm; C Murray Skeaff; V Gudnason; P J Talmud; Steve E Humphries
Variants in the cholesterol ester transfer protein and lipoprotein lipase genes are predictors of plasma cholesterol response to dietary change.
Atherosclerosis 2000;152(2):327-36.
2000: A Woods; David Brull; Steve E Humphries; Hugh E Montgomery
Genetics of inflammation and risk of coronary artery disease: the central role of interleukin-6.
European heart journal 2000;21(19):1574-83.
2000: Philippa J Talmud; Jutta Palmen; G Miller; Steve E Humphries
Effect of microsomal triglyceride transfer protein gene variants (-493G > T, Q95H and H297Q) on plasma lipid levels in healthy middle-aged UK men.
Annals of human genetics 2000;64(Pt 4):269-76.
2000: Dawn M Waterworth; Jaroslav A Hubacek; Jan Pitha; J Kovar; Rudolf Poledne; Steve E Humphries; Philippa J Talmud
Plasma levels of remnant particles are determined in part by variation in the APOC3 gene insulin response element and the APOCI-APOE cluster.
Journal of lipid research 2000;41(7):1103-9.
2000: Philippa J Talmud; Karen L Edwards; C M Turner; B Newman; Jutta Palmen; Steve E Humphries; Melissa A Austin
Linkage of the cholesteryl ester transfer protein (CETP) gene to LDL particle size: use of a novel tetranucleotide repeat within the CETP promoter.
Circulation 2000;101(21):2461-6.
2000: David M Flavell; Inés Pineda Torra; Yalda Jamshidi; D Evans; JR Diamond; Robert S Elkeles; SR Bujac; George Miller; Philippa J Talmud; Bart Staels; Steve E Humphries
Variation in the PPARalpha gene is associated with altered function in vitro and plasma lipid concentrations in Type II diabetic subjects.
Diabetologia 2000;43(5):673-80.
2000: KE Heath; Ian N M Day; Steve E Humphries
Universal primer quantitative fluorescent multiplex (UPQFM) PCR: a method to detect major and minor rearrangements of the low density lipoprotein receptor gene.
Journal of medical genetics 2000;37(4):272-80.
2000: Alison J Wallace; Steve E Humphries; R M Fisher; Jim I Mann; Alex Chisholm; Wayne H F Sutherland
Genetic factors associated with response of LDL subfractions to change in the nature of dietary fat.
Atherosclerosis 2000;149(2):387-94.
2000: Anders Hamsten; Mikko Syvänne; Angela Silveira; Le Luong; Markku S Nieminen; Steve E Humphries; M Heikki Frick; Marja-Riitta Taskinen
Fibrinolytic proteins and progression of coronary artery disease in relation to gemfibrozil therapy.
Thrombosis and haemostasis 2000;83(3):397-403.
2000: Philippa J Talmud; SR Bujac; S Hall; George J Miller; Steve E Humphries
Substitution of asparagine for aspartic acid at residue 9 (D9N) of lipoprotein lipase markedly augments risk of ischaemic heart disease in male smokers.
Atherosclerosis 2000;149(1):75-81.
2000: A G Williams; Mark P Rayson; Mick Jubb; Michael J World; David R Woods; M Hayward; J Martin; Steve E Humphries; Hugh E Montgomery
The ACE gene and muscle performance.
Nature 2000;403(6770):614.
2000: John S Yudkin; Meena Kumari; Steve E Humphries; Vidya Mohamed-Ali
Inflammation, obesity, stress and coronary heart disease: is interleukin-6 the link?
Atherosclerosis 2000;148(2):209-14.
2000: Dalya Marks; David Wonderling; Margaret Thorogood; H Lambert; Steve E Humphries; H A W Neil
Screening for hypercholesterolaemia versus case finding for familial hypercholesterolaemia: a systematic review and cost-effectiveness analysis.
Health technology assessment (Winchester, England) 2000;4(29):1-123.
1999: M K Bolla; N Wood; Steve E Humphries
Rapid determination of apolipoprotein E genotype using a heteroduplex generator.
Journal of lipid research 1999;40(12):2340-5.
1999: Saul G Myerson; Harry Hemingway; R Budget; J Martin; Steve E Humphries; Hugh Montgomery
Human angiotensin I-converting enzyme gene and endurance performance.
Journal of applied physiology (Bethesda, Md. : 1985) 1999;87(4):1313-6.
1999: Steven Shea; Carmen R Isasi; Sarah C Couch; Thomas J Starc; Russell P Tracy; Richard J Deckelbaum; P Talmud; Lars Berglund; Steve E Humphries
Relations of plasma fibrinogen level in children to measures of obesity, the (G-455-->A) mutation in the beta-fibrinogen promoter gene, and family history of ischemic heart disease: the Columbia University BioMarkers Study.
American journal of epidemiology 1999;150(7):737-46.
1999: Steve E Humphries; Le Luong; Hugh E Montgomery; I N Day; Vidya Mohamed-Ali; John S Yudkin
Gene-environment interaction in the determination of levels of plasma fibrinogen.
Thrombosis and haemostasis 1999;82(2):818-25.
1999: CM Dollery; Steve E Humphries; A McClelland; David S Latchman; Jean R McEwan
In vivo adenoviral gene transfer of TIMP-1 after vascular injury reduces neointimal formation.
Annals of the New York Academy of Sciences 1999;878():742-3.
1999: CM Dollery; Steve E Humphries; A McClelland; David S Latchman; Jean R McEwan
Expression of tissue inhibitor of matrix metalloproteinases 1 by use of an adenoviral vector inhibits smooth muscle cell migration and reduces neointimal hyperplasia in the rat model of vascular balloon injury.
Circulation 1999;99(24):3199-205.
1999: Lema Haddad; Ian N M Day; S Hunt; R R Williams; Steve E Humphries; P N Hopkins
Evidence for a third genetic locus causing familial hypercholesterolemia. A non-LDLR, non-APOB kindred.
Journal of lipid research 1999;40(6):1113-22.
1999: Dawn M Waterworth; J Ribalta; Viviane Nicaud; J Dallongeville; Steve E Humphries; Philippa J Talmud
ApoCIII gene variants modulate postprandial response to both glucose and fat tolerance tests.
Circulation 1999;99(14):1872-7.
1999: KE Heath; Vilmundur Gudnason; Steve E Humphries; M Seed
The type of mutation in the low density lipoprotein receptor gene influences the cholesterol-lowering response of the HMG-CoA reductase inhibitor simvastatin in patients with heterozygous familial hypercholesterolaemia.
Atherosclerosis 1999;143(1):41-54.
1999: Hugh Montgomery; P Clarkson; M Barnard; J Bell; Audrey E Brynes; CM Dollery; Joseph V Hajnal; Harry Hemingway; D Mercer; P Jarman; R Marshall; K Prasad; Mark P Rayson; Nadeem Saeed; Philippa J Talmud; L Thomas; Mick Jubb; Michael J World; Steve E Humphries
Angiotensin-converting-enzyme gene insertion/deletion polymorphism and response to physical training.
Lancet 1999;353(9152):541-5.
1999: Steve E Humphries; J A Henry; H E Montgomery
Gene-environment interaction in the determination of levels of haemostatic variables involved in thrombosis and fibrinolysis.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 1999;10 Suppl 1():S17-21.
1999: Thomas Sanders; Tamara de Grassi; George J Miller; Steve E Humphries
Dietary oleic and palmitic acids and postprandial factor VII in middle-aged men heterozygous and homozygous for factor VII R353Q polymorphism.
The American journal of clinical nutrition 1999;69(2):220-5.
1999: RM Fisher; H Burke; Viviane Nicaud; C Ehnholm; Steve E Humphries
Effect of variation in the apo A-IV gene on body mass index and fasting and postprandial lipids in the European Atherosclerosis Research Study II. EARS Group.
Journal of lipid research 1999;40(2):287-94.
1998: V De Stefano; V Dekou; Viviane Nicaud; J F Chasse; J London; David Stansbie; Steve E Humphries; Vilmundur Gudnason
Linkage disequilibrium at the cystathionine beta synthase (CBS) locus and the association between genetic variation at the CBS locus and plasma levels of homocysteine. The Ears II Group. European Atherosclerosis Research Study.
Annals of human genetics 1998;62(Pt 6):481-90.
1998: M S Sumeray; H E Montgomery; Steve E Humphries
Beyond coagulation: fibrinogen as a cause of cardiovascular surgical disease.
Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy 1998;12(3):261-5.
1998: Steve E Humphries; Le Luong; Philippa J Talmud; M Heikki Frick; Y Antero Kesäniemi; Amos Pasternack; Marja-Riitta Taskinen; Mikko Syvänne
The 5A/6A polymorphism in the promoter of the stromelysin-1 (MMP-3) gene predicts progression of angiographically determined coronary artery disease in men in the LOCAT gemfibrozil study. Lopid Coronary Angiography Trial.
Atherosclerosis 1998;139(1):49-56.
1998: D J Wilson; M Gahan; Lema Haddad; KE Heath; Ros A Whittall; R R Williams; Steve E Humphries; Ian N M Day
A World Wide Web site for low-density lipoprotein receptor gene mutations in familial hypercholesterolemia: sequence-based, tabular, and direct submission data handling.
The American journal of cardiology 1998;81(12):1509-11.
1998: Philippa J Talmud; S Hall; Steve Holleran; Rajasekhar Ramakrishnan; Henry N Ginsberg; Steve E Humphries
LPL promoter -93T/G transition influences fasting and postprandial plasma triglycerides response in African-Americans and Hispanics.
Journal of lipid research 1998;39(6):1189-96.
1998: Hugh E Montgomery; R Marshall; Harry Hemingway; Saul G Myerson; P Clarkson; CM Dollery; M Hayward; D E Holliman; Mick Jubb; Michael J World; E L Thomas; Audrey E Brynes; N Saeed; M Barnard; J D Bell; K Prasad; Mark P Rayson; P J Talmud; Steve E Humphries
Human gene for physical performance.
Nature 1998;393(6682):221-2.
1998: J M Curran; A Evans; D Arveiler; G Luc; J B Ruidavets; Steve E Humphries; F R Green
The alpha fibrinogen T/A312 polymorphism in the ECTIM study.
Thrombosis and haemostasis 1998;79(5):1057-8.
1998: SD O'Dell; M K Bolla; G J Miller; J A Cooper; Steve E Humphries; Ian N M Day
W64R mutation in beta-3-adrenergic receptor gene and weight in a large population sample.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 1998;22(4):377-9.
1998: Steve E Humphries; Viviane Nicaud; J Margalef; L Tiret; Philippa J Talmud
Lipoprotein lipase gene variation is associated with a paternal history of premature coronary artery disease and fasting and postprandial plasma triglycerides: the European Atherosclerosis Research Study (EARS).
Arteriosclerosis, thrombosis, and vascular biology 1998;18(4):526-34.
1998: Vilmundur Gudnason; David Stansbie; Jeff Scott; Ann Bowron; Viviane Nicaud; Steve E Humphries
C677T (thermolabile alanine/valine) polymorphism in methylenetetrahydrofolate reductase (MTHFR): its frequency and impact on plasma homocysteine concentration in different European populations. EARS group.
Atherosclerosis 1998;136(2):347-54.
1998: Melissa A Austin; P J Talmud; L A Luong; L Haddad; I N Day; Beth Newman; Karen L Edwards; Ronald M Krauss; Steve E Humphries
Candidate-gene studies of the atherogenic lipoprotein phenotype: a sib-pair linkage analysis of DZ women twins.
American journal of human genetics 1998;62(2):406-19.
1998: S D O'Dell; D J Wilson; P N Durrington; Steve E Humphries; Ian N M Day
CpG-PCR combined with sample pooling and mutant enrichment for CpG mutation screening in population studies.
Clinical chemistry 1998;44(1):183-5.
1997: Steve E Humphries; Vilmundur Gudnason; Ros A Whittall; Ian N M Day
Single-strand conformation polymorphism analysis with high throughput modifications, and its use in mutation detection in familial hypercholesterolemia. The IFCC Scientific Division: Committee on Molecular Biology Techniques.
Journal of the International Federation of Clinical Chemistry / IFCC 1997;9(4):156-61.
1997: K E Heath; L A Luong; J V Leonard; A Chester; C C Shoulders; J Scott; Helen Middleton-Price; Steve E Humphries; P J Talmud
The use of a highly informative CA repeat polymorphism within the abetalipoproteinaemia locus (4q22-24).
Prenatal diagnosis 1997;17(12):1181-6.
1997: RM Fisher; Steve E Humphries; Philippa J Talmud
Common variation in the lipoprotein lipase gene: effects on plasma lipids and risk of atherosclerosis.
Atherosclerosis 1997;135(2):145-59.
1997: Lema Haddad; Lorna B Day; J Attwood; Sue Povey; Steve E Humphries; Ian N M Day
Development of a microsatellite-based approach to co-segregation analysis of familial hypercholesterolaemic kindreds.
Annals of human genetics 1997;61(Pt 6):497-506.
1997: John S Yudkin; C Andres; Vidya Mohamed-Ali; M Gould; Arshia Panahloo; A P Haines; Steve E Humphries; P Talmud
The angiotensin-converting enzyme gene and the angiotensin II type I receptor gene as candidate genes for microalbuminuria. A study in nondiabetic and non-insulin-dependent diabetic subjects.
Arteriosclerosis, thrombosis, and vascular biology 1997;17(10):2188-91.
1997: S Hall; G Chu; George Miller; K Cruickshank; Jackie A Cooper; Steve E Humphries; Philippa J Talmud
A common mutation in the lipoprotein lipase gene promoter, -93T/G, is associated with lower plasma triglyceride levels and increased promoter activity in vitro.
Arteriosclerosis, thrombosis, and vascular biology 1997;17(10):1969-76.
1997: SD O'Dell; G J Miller; J A Cooper; Peter C Hindmarsh; P Jane Pringle; H Ford; Steve E Humphries; Ian N M Day
Apal polymorphism in insulin-like growth factor II (IGF2) gene and weight in middle-aged males.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 1997;21(9):822-5.
1997: K E Webb; A M Henney; SC Anglin; Steve E Humphries; Jean R McEwan
Expression of matrix metalloproteinases and their inhibitor TIMP-1 in the rat carotid artery after balloon injury.
Arteriosclerosis, thrombosis, and vascular biology 1997;17(9):1837-44.
1997: Hugh E Montgomery; P Clarkson; CM Dollery; K Prasad; M A Losi; Harry Hemingway; D Statters; Mick Jubb; M Girvain; A Varnava; Michael J World; John Deanfield; Philippa J Talmud; Jean R McEwan; William J McKenna; Steve E Humphries
Association of angiotensin-converting enzyme gene I/D polymorphism with change in left ventricular mass in response to physical training.
Circulation 1997;96(3):741-7.
1997: C Gerdes; RM Fisher; Viviane Nicaud; JM Boer; Steve E Humphries; Philippa J Talmud; Ole Faergeman
Lipoprotein lipase variants D9N and N291S are associated with increased plasma triglyceride and lower high-density lipoprotein cholesterol concentrations: studies in the fasting and postprandial states: the European Atherosclerosis Research Studies.
Circulation 1997;96(3):733-40.
1997: J A Henry; M Bolla; C Osmond; C Fall; D J Barker; Steve E Humphries
The effects of genotype and infant weight on adult plasma levels of fibrinogen, factor VII, and LDL cholesterol are additive.
Journal of medical genetics 1997;34(7):553-8.
1997: Steve E Humphries; Arshia Panahloo; Hugh E Montgomery; F Green; John S Yudkin
Gene-environment interaction in the determination of levels of haemostatic variables involved in thrombosis and fibrinolysis.
Thrombosis and haemostasis 1997;78(1):457-61.
1997: Philippa J Talmud; Steve E Humphries
Apolipoprotein C-III gene variation and dyslipidaemia.
Current opinion in lipidology 1997;8(3):154-8.
1997: Steve E Humphries; D Galton; P Nicholls
Genetic testing for familial hypercholesterolaemia: practical and ethical issues.
QJM : monthly journal of the Association of Physicians 1997;90(3):169-81.
1997: Steve E Humphries; Vilmundur Gudnason; Ros A Whittall; Ian N M Day
Single-strand conformation polymorphism analysis with high throughput modifications, and its use in mutation detection in familial hypercholesterolemia. International Federation of Clinical Chemistry Scientific Division: Committee on Molecular Biology Techniques.
Clinical chemistry 1997;43(3):427-35.
1997: Ian N M Day; Lema Haddad; SD O'Dell; Lorna B Day; Ros A Whittall; Steve E Humphries
Identification of a common low density lipoprotein receptor mutation (R329X) in the south of England: complete linkage disequilibrium with an allele of microsatellite D19S394.
Journal of medical genetics 1997;34(2):111-6.
1997: F Mailly; Jutta Palmen; D P R Muller; T Gibbs; J Lloyd; J Brunzell; P Durrington; K Mitropoulos; J Betteridge; G Watts; H Lithell; F Angelico; Steve E Humphries; Philippa J Talmud
Familial lipoprotein lipase (LPL) deficiency: a catalogue of LPL gene mutations identified in 20 patients from the UK, Sweden, and Italy.
Human mutation 1997;10(6):465-73.
1997: Ian N M Day; Ros A Whittall; SD O'Dell; Lema Haddad; M K Bolla; Vilmundur Gudnason; Steve E Humphries
Spectrum of LDL receptor gene mutations in heterozygous familial hypercholesterolemia.
Human mutation 1997;10(2):116-27.
1997: Vilmundur Gudnason; G Sigurdsson; H Nissen; Steve E Humphries
Common founder mutation in the LDL receptor gene causing familial hypercholesterolaemia in the Icelandic population.
Human mutation 1997;10(1):36-44.
1997: Vilmundur Gudnason; K Thormar; Steve E Humphries
Interaction of the cholesteryl ester transfer protein I405V polymorphism with alcohol consumption in smoking and non-smoking healthy men, and the effect on plasma HDL cholesterol and apoAI concentration.
Clinical genetics 1997;51(1):15-21.
1996: A E Thomas; F R Green; Steve E Humphries
Association of genetic variation at the beta-fibrinogen gene locus and plasma fibrinogen levels; interaction between allele frequency of the G/A-455 polymorphism, age and smoking.
Clinical genetics 1996;50(4):184-90.
1996: Philippa J Talmud; O J Tamplin; K Heath; D Gaffney; Ian N M Day; Steve E Humphries
Rapid testing for three mutations causing familial defective apolipoprotein B100 in 562 patients with familial hypercholesterolaemia.
Atherosclerosis 1996;125(1):135-7.
1996: Tjerk W A de Bruin; F Mailly; H H van Barlingen; R Fisher; M Castro Cabezas; Philippa J Talmud; Geesje M Dallinga-Thie; Steve E Humphries
Lipoprotein lipase gene mutations D9N and N291S in four pedigrees with familial combined hyperlipidaemia.
European journal of clinical investigation 1996;26(8):631-9.
1996: S D O'Dell; Steve E Humphries; Ian N M Day
PCR induction of a TaqI restriction site at any CpG dinucleotide using two mismatched primers (CpG-PCR).
Genome research 1996;6(6):558-68.
1996: Vilmundur Gudnason; Ian N M Day; Steve E Humphries
Use of the single strand conformation polymorphism method for rapid screening for mutations in the low density lipoprotein receptor gene in patients with familial hypercholesterolemia: effect on plasma lipid levels of different classes of mutations.
Zeitschrift für Gastroenterologie 1996;34 Suppl 3():6-8.
1996: S Ye; P Eriksson; A Hamsten; Markku T Kurkinen; Steve E Humphries; A M Henney
Progression of coronary atherosclerosis is associated with a common genetic variant of the human stromelysin-1 promoter which results in reduced gene expression.
The Journal of biological chemistry 1996;271(22):13055-60.
1996: F Mailly; RM Fisher; Viviane Nicaud; Le Luong; A E Evans; Pedro Marques-Vidal; Gérald Luc; Dominique Arveiler; J M Bard; Odette Poirier; Philippa J Talmud; Steve E Humphries
Association between the LPL-D9N mutation in the lipoprotein lipase gene and plasma lipid traits in myocardial infarction survivors from the ECTIM Study.
Atherosclerosis 1996;122(1):21-8.
1996: H E Montgomery; P Clarkson; O M Nwose; D P Mikailidis; I A Jagroop; CM Dollery; J Moult; F Benhizia; John Deanfield; Mick Jubb; Michael J World; Jean R McEwan; A Winder; Steve E Humphries
The acute rise in plasma fibrinogen concentration with exercise is influenced by the G-453-A polymorphism of the beta-fibrinogen gene.
Arteriosclerosis, thrombosis, and vascular biology 1996;16(3):386-91.
1996: Steve E Humphries; V Gudnason; R E Whittall; I N Day
High throughput modifications of single-strand conformation polymorphism analysis : mutation detection in familial hypercholesterolemia.
Methods in molecular medicine 1996;5():321-40.
1996: I N Day; M Bolla; L Haddad; S O'Dell; Steve E Humphries
Microtiter Array Diagonal Gel Electrophoresis (MADGE) for Population Scale Genotype Analyses.
Methods in molecular medicine 1996;5():269-81.
1995: Arshia Panahloo; C Andrès; Vidya Mohamed-Ali; M M Gould; Philippa J Talmud; Steve E Humphries; John S Yudkin
The insertion allele of the ACE gene I/D polymorphism. A candidate gene for insulin resistance?
Circulation 1995;92(12):3390-3.
1995: Vilmundur Gudnason; D P Muller; J K Lloyd; Steve E Humphries
Response to drugs and diet in a compound heterozygote for familial hypercholesterolaemia.
Archives of disease in childhood 1995;73(6):538-40.
1995: Ian N M Day; Steve E Humphries; S Richards; D Norton; M Reid
High-throughput genotyping using horizontal polyacrylamide gels with wells arranged for microplate array diagonal gel electrophoresis (MADGE).
BioTechniques 1995;19(5):830-5.
1995: M K Bolla; Lema Haddad; Steve E Humphries; AF Winder; Ian N M Day
High-throughput method for determination of apolipoprotein E genotypes with use of restriction digestion analysis by microplate array diagonal gel electrophoresis.
Clinical chemistry 1995;41(11):1599-604.
1995: Steve E Humphries; R E Peacock; Philippa J Talmud
The genetic determinants of plasma cholesterol and response to diet.
Baillière's clinical endocrinology and metabolism 1995;9(4):797-823.
1995: RM Fisher; F Mailly; R E Peacock; A Hamsten; Mary Seed; J S Yudkin; U Beisiegel; G Feussner; G Miller; Steve E Humphries
Interaction of the lipoprotein lipase asparagine 291-->serine mutation with body mass index determines elevated plasma triacylglycerol concentrations: a study in hyperlipidemic subjects, myocardial infarction survivors, and healthy adults.
Journal of lipid research 1995;36(10):2104-12.
1995: S Ye; F R Green; Pierre-Yves Scarabin; Viviane Nicaud; L Bara; Sally J Dawson; Steve E Humphries; A Evans; G Luc; Jean-Pierre Cambou
The 4G/5G genetic polymorphism in the promoter of the plasminogen activator inhibitor-1 (PAI-1) gene is associated with differences in plasma PAI-1 activity but not with risk of myocardial infarction in the ECTIM study. Etude CasTemoins de I'nfarctus du Mycocarde.
Thrombosis and haemostasis 1995;74(3):837-41.
1995: Steve E Humphries; Philippa J Talmud
Hyperlipidaemia associated with genetic variation in the apolipoprotein B gene.
Current opinion in lipidology 1995;6(4):215-22.
1995: A E Thomas; F R Green; H Lamlum; Steve E Humphries
The association of combined alpha and beta fibrinogen genotype on plasma fibrinogen levels in smokers and non-smokers.
Journal of medical genetics 1995;32(8):585-9.
1995: Ian N M Day; S D O'Dell; I D Cash; Steve E Humphries; G P Weavind
Electrophoresis for genotyping: temporal thermal gradient gel electrophoresis for profiling of oligonucleotide dissociation.
Nucleic acids research 1995;23(13):2404-12.
1995: Ros A Whittall; Vilmundur Gudnason; G P Weavind; Lorna B Day; Steve E Humphries; Ian N M Day
Utilities for high throughput use of the single strand conformational polymorphism method: screening of 791 patients with familial hypercholesterolaemia for mutations in exon 3 of the low density lipoprotein receptor gene.
Journal of medical genetics 1995;32(7):509-15.
1995: R E Peacock; F Karpe; Philippa J Talmud; A Hamsten; Steve E Humphries
Common variation in the gene for apolipoprotein B modulates postprandial lipoprotein metabolism: a hypothesis generating study.
Atherosclerosis 1995;116(1):135-45.
1995: H E Montgomery; PJ Keeling; JH Goldman; Steve E Humphries; P J Talmud; W J McKenna
Lack of association between the insertion/deletion polymorphism of the angiotensin-converting enzyme gene and idiopathic dilated cardiomyopathy.
Journal of the American College of Cardiology 1995;25(7):1627-31.
1995: Ian N M Day; Ros A Whittall; Vilmundur Gudnason; Steve E Humphries
Dried template DNA, dried PCR oligonucleotides and mailing in 96-well plates: LDL receptor gene mutation screening.
BioTechniques 1995;18(6):981-4.
1995: S D O'Dell; Steve E Humphries; Ian N M Day
Rapid methods for population-scale analysis for gene polymorphisms: the ACE gene as an example.
British heart journal 1995;73(4):368-71.
1995: S Ye; G F Watts; S Mandalia; Steve E Humphries; A M Henney
Preliminary report: genetic variation in the human stromelysin promoter is associated with progression of coronary atherosclerosis.
British heart journal 1995;73(3):209-15.
1995: Arshia Panahloo; Vidya Mohamed-Ali; A Lane; F Green; Steve E Humphries; John S Yudkin
Determinants of plasminogen activator inhibitor 1 activity in treated NIDDM and its relation to a polymorphism in the plasminogen activator inhibitor 1 gene.
Diabetes 1995;44(1):37-42.
1995: Steve E Humphries; S Ye; P Talmud; L Bara; L Wilhelmsen; L Tiret
European Atherosclerosis Research Study: genotype at the fibrinogen locus (G-455-A beta-gene) is associated with differences in plasma fibrinogen levels in young men and women from different regions in Europe. Evidence for gender-genotype-environment interaction.
Arteriosclerosis, thrombosis, and vascular biology 1995;15(1):96-104.
1994: Vilmundur Gudnason; Ian N M Day; Steve E Humphries
Effect on plasma lipid levels of different classes of mutations in the low-density lipoprotein receptor gene in patients with familial hypercholesterolemia.
Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association 1994;14(11):1717-22.
1994: A Laywood; Ros A Whittall; Vilmundur Gudnason; Steve E Humphries; Ian N M Day
Handling of large (300 x 400 mm), thin (0.4 mm) polyacrylamide gels and recovery as dried gels.
BioTechniques 1994;17(5):850-4.
1994: R E Peacock; A Hamsten; J Johansson; P Nilsson-Ehle; Steve E Humphries
Associations of genotypes at the apolipoprotein AI-CIII-AIV, apolipoprotein B and lipoprotein lipase gene loci with coronary atherosclerosis and high density lipoprotein subclasses.
Clinical genetics 1994;46(4):273-82.
1994: Steve E Humphries; R Peacock; A Dunning; A Lane; F Green; A Hamsten
Identification of genetic variation that determines levels of plasma triglycerides and hypercoagulability.
Clinical genetics 1994;46(1 Spec No):19-31.
1994: Steve E Humphries; A Lane; F R Green; J Cooper; G J Miller
Factor VII coagulant activity and antigen levels in healthy men are determined by interaction between factor VII genotype and plasma triglyceride concentration.
Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association 1994;14(2):193-8.
1994: Peter de Knijff; F Green; L G Johansen; D Grootendorst; A Temple; J K Cruickshank; Steve E Humphries; Jørgen Jespersen; Cornelis Kluft
New alleles in F7 VNTR.
Human molecular genetics 1994;3(2):384.
1994: Steve E Humphries
The application of molecular biology techniques to the diagnosis of hyperlipidaemia and other risk factors for cardio-vascular disease.
Annales de biologie clinique 1994;52(1):67-75.
1994: Mary Seed; F Mailly; D Vallance; E Doherty; A Winder; Philippa J Talmud; Steve E Humphries
Lipoprotein lipase activity in patients with combined hyperlipidaemia.
The Clinical investigator 1994;72(2):100-6.
1994: Philippa J Talmud; S Ye; Steve E Humphries
Polymorphism in the promoter region of the apolipoprotein AI gene associated with differences in apolipoprotein AI levels: the European Atherosclerosis Research Study.
Genetic epidemiology 1994;11(3):265-80.
1993: Steve E Humphries; F Mailly; Vilmundur Gudnason; Philippa J Talmud
The molecular genetics of pediatric lipid disorders: recent progress and future research directions.
Pediatric research 1993;34(4):403-15.
1993: Vilmundur Gudnason; L King-Underwood; Mary Seed; Xi-Ming Sun; Anne K Soutar; Steve E Humphries
Identification of recurrent and novel mutations in exon 4 of the LDL receptor gene in patients with familial hypercholesterolemia in the United Kingdom.
Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association 1993;13(1):56-63.
1992: Steve E Humphries
The application of molecular biology techniques to the diagnosis of hyperlipidaemia and other risk factors for cardiovascular disease. Committee on Molecular Biology Techniques in Clinical Chemistry of the International Federation of Clinical Chemistry (IFCC).
Journal of the International Federation of Clinical Chemistry / IFCC 1992;4(5):208-18.
1992: R E Peacock; A Hamsten; P Nilsson-Ehle; Steve E Humphries
Associations between lipoprotein lipase gene polymorphisms and plasma correlations of lipids, lipoproteins and lipase activities in young myocardial infarction survivors and age-matched healthy individuals from Sweden.
Atherosclerosis 1992;97(2-3):171-85.
1992: Steve E Humphries; A Lane; S Dawson; F R Green
The study of gene-environment interactions that influence thrombosis and fibrinolysis. Genetic variation at the loci for factor VII and plasminogen activator inhibitor-1.
Archives of pathology & laboratory medicine 1992;116(12):1322-9.
1992: Steve E Humphries; A Dunning; Chun-Fang Xu; R Peacock; Philippa J Talmud; A Hamsten
DNA polymorphism studies. Approaches to elucidating multifactorial ischaemic heart disease: the apo B gene as an example.
Annals of medicine 1992;24(5):349-56.
1992: Steve E Humphries; F R Green; A Temple; S Dawson; A Henney; C H Kelleher; H Wilkes; Tom W Meade; B Wiman; A Hamsten
Genetic factors determining thrombosis and fibrinolysis.
Annals of epidemiology 1992;2(4):371-85.
1992: A M Henney; D H Brotherton; A H Child; Steve E Humphries; R Grahame
Segregation analysis of collagen genes in two families with joint hypermobility syndrome.
British journal of rheumatology 1992;31(3):169-74.
1992: H H Renges; R Peacock; A M Dunning; P Talmud; Steve E Humphries
Genetic relationship between the 3'-VNTR and diallelic apolipoprotein B gene polymorphisms: haplotype analysis in individuals of European and south Asian origin.
Annals of human genetics 1992;56(Pt 1):11-33.
1992: F Mailly; P Moll; B A Kottke; M I Kamboh; Steve E Humphries; R E Ferrell
Estimation of the frequency of isoform-genotype discrepancies at the apolipoprotein E locus in heterozygotes for the isoforms.
Genetic epidemiology 1992;9(4):239-48.
1991: H H Renges; D B Wile; P M McKeigue; Michael Marmot; Steve E Humphries
Apolipoprotein B gene polymorphisms are associated with lipid levels in men of South Asian descent.
Atherosclerosis 1991;91(3):267-75.
1991: R Houlston; B Lewis; Steve E Humphries
Polymorphisms of the apolipoprotein B and E genes and their possible roles in familial and non-familial combined hyperlipidaemia.
Disease markers 1991;9(6):319-25.
1991: A E Thomas; F R Green; cecily kelleher; H C Wilkes; P J Brennan; Tom W Meade; Steve E Humphries
Variation in the promoter region of the beta fibrinogen gene is associated with plasma fibrinogen levels in smokers and non-smokers.
Thrombosis and haemostasis 1991;65(5):487-90.
1991: F Mailly; Chun-Fang Xu; M Xhignesse; Suzanne Lussier-Cacan; Philippa J Talmud; Jean Davignon; Steve E Humphries; A C Nestruck
Characterization of a new apolipoprotein E5 variant detected in two French-Canadian subjects.
Journal of lipid research 1991;32(4):613-20.