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Steve Humphries

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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TOP 3
Qureshi Nadeem; Humphries Steve E; Seed Mary; Rowlands Philip; Minhas Rubin;
Identification and management of familial hypercholesterolaemia: what does it mean to primary care?
Taylor A; Martin B; Wang D; Patel K; Humphries S E; Norbury G
Multiplex ligation-dependent probe amplification analysis to screen for deletions and duplications of the LDLR gene in patients with familial hypercholesterolaemia.
Drenos Fotios; Talmud Philippa J; Casas Juan P; Smeeth Liam; Palmen Jutta; Humphries Steve E; Hingorani Aroon D
Integrated associations of genotypes with multiple blood biomarkers linked to coronary heart disease risk.

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All Publications

2009: Qureshi Nadeem; Humphries Steve E; Seed Mary; Rowlands Philip; Minhas Rubin;
Identification and management of familial hypercholesterolaemia: what does it mean to primary care?
The British journal of general practice : the journal of the Royal College of General Practitioners 2009;59(567):773-6.
2009: Taylor A; Martin B; Wang D; Patel K; Humphries S E; Norbury G
Multiplex ligation-dependent probe amplification analysis to screen for deletions and duplications of the LDLR gene in patients with familial hypercholesterolaemia.
Clinical genetics 2009;76(1):69-75.
2009: Drenos Fotios; Talmud Philippa J; Casas Juan P; Smeeth Liam; Palmen Jutta; Humphries Steve E; Hingorani Aroon D
Integrated associations of genotypes with multiple blood biomarkers linked to coronary heart disease risk.
Human molecular genetics 2009;18(12):2305-16.
2009: Sanderson Saskia C; Kumari Meena; Brunner Eric J; Miller Michelle A; Rumley Ann; Lowe Gordon D; Marmot Michael G; Humphries Steve E
Association between IL6 gene variants -174G>C and -572G>C and serum IL-6 levels: interactions with social position in the Whitehall II cohort.
Atherosclerosis 2009;204(2):459-64.
2009: Prior Sarah L; Gable David R; Cooper Jackie A; Bain Stephen C; Hurel Steven J; Humphries Steve E; Stephens Jeffrey W
Association between the adiponectin promoter rs266729 gene variant and oxidative stress in patients with diabetes mellitus.
European heart journal 2009;30(10):1263-9.
2009: Sanders Julie; Hawe Emma; Brull David J; Hubbart Christina; Lowe Gordon D O; Rumley Ann; Humphries Steve E; Montgomery Hugh E
Higher IL-6 levels but not IL6 -174G>C or -572G>C genotype are associated with post-operative complication following coronary artery bypass graft (CABG) surgery.
Atherosclerosis 2009;204(1):196-201.
2009: Kotronen Anna; Yki-Järvinen Hannele; Aminoff Anna; Bergholm Robert; Pietiläinen Kirsi H; Westerbacka Jukka; Talmud Philippa J; Humphries Steve E; Hamsten Anders; Isomaa Bo; Groop Leif; Orho-Melander Marju; Ehrenborg Ewa; Fisher Rachel M
Genetic variation in the ADIPOR2 gene is associated with liver fat content and its surrogate markers in three independent cohorts.
European journal of endocrinology / European Federation of Endocrine Societies 2009;160(4):593-602.
2009: Leigh Sarah E A; Leren Trond P; Humphries Steve E
Commentary PCSK9 variants: A new database.
Atherosclerosis 2009;203(1):32-3.
2009: Thompson Andrew R; Golledge Jonathan; Cooper Jackie A; Hafez Hany; Norman Paul E; Humphries Steve E
Sequence variant on 9p21 is associated with the presence of abdominal aortic aneurysm disease but does not have an impact on aneurysmal expansion.
European journal of human genetics : EJHG 2009;17(3):391-4.
2009: Hingorani Aroon D; Shah Tina; Casas Juan P; Humphries Steve E; Talmud Philippa J
C-reactive protein and coronary heart disease: predictive test or therapeutic target?
Clinical chemistry 2009;55(2):239-55.
2009: Sanderson Saskia C; Waller Jo; Jarvis Martin J; Humphries Steve E; Wardle Jane
Awareness of lifestyle risk factors for cancer and heart disease among adults in the UK.
Patient education and counseling 2009;74(2):221-7.
2009: Smith Andrew J P; Humphries Steve E
Cytokine and cytokine receptor gene polymorphisms and their functionality.
Cytokine & growth factor reviews 2009;20(1):43-59.
2009: Shah Tina; Casas Juan P; Cooper Jackie A; Tzoulaki Ioanna; Sofat Reecha; McCormack Valerie; Smeeth Liam; Deanfield John E; Lowe Gordon D; Rumley Ann; Fowkes F Gerald R; Humphries Steve E; Hingorani Aroon D
Critical appraisal of CRP measurement for the prediction of coronary heart disease events: new data and systematic review of 31 prospective cohorts.
International journal of epidemiology 2009;38(1):217-31.
2009: Salpea Klelia D; Gable David R; Cooper Jackie A; Stephens Jeffrey W; Hurel Steven J; Ireland Helen A; Feher Michael D; Godsland Ian F; Humphries Steve E
The effect of WNT5B IVS3C>G on the susceptibility to type 2 diabetes in UK Caucasian subjects.
Nutrition, metabolism, and cardiovascular diseases : NMCD 2009;19(2):140-5.
2009: Nibali L; D'Aiuto F; Donos N; Griffiths G S; Parkar M; Tonetti M S; Humphries S E; Brett P M
Association between periodontitis and common variants in the promoter of the interleukin-6 gene.
Cytokine 2009;45(1):50-4.
2009: Smith Andrew J P; Humphries Steve E
Characterization of DNA-binding proteins using multiplexed competitor EMSA.
Journal of molecular biology 2009;385(3):714-7.
2009: Qureshi Nadeem; Armstrong Sarah; Saukko Paula; Sach Tracey; Middlemass Jo; Evans Phil H; Kai Joe; Farrimond Hannah; Humphries Steve E
Realising the potential of the family history in risk assessment and primary prevention of coronary heart disease in primary care: ADDFAM study protocol.
BMC health services research 2009;9():184.
2009: Neil Andrew; Humphries Steve E
Statins and familial hypercholesterolaemia.
BMJ (Clinical research ed.) 2009;338():a3041.
2008: Talmud Philippa J; Smart Melissa; Presswood Edward; Cooper Jackie A; Nicaud Viviane; Drenos Fotios; Palmen Jutta; Marmot Michael G; Boekholdt S Matthijs; Wareham Nicholas J; Khaw Kay-Tee; Kumari Meena; Humphries Steve E;
ANGPTL4 E40K and T266M: effects on plasma triglyceride and HDL levels, postprandial responses, and CHD risk.
Arteriosclerosis, thrombosis, and vascular biology 2008;28(12):2319-25.
2008: Plunkett Adrian; Agbeko Rachel S; Li Kawah; Humphries Steve E; Klein Nigel J; Peters Mark J
Angiotensin-converting enzyme D allele does not influence susceptibility to acute hypoxic respiratory failure in children.
Intensive care medicine 2008;34(12):2279-83.
2008: Neil Andrew; Cooper Jackie; Betteridge John; Capps Nigel; McDowell Ian; Durrington Paul; Seed Mary; Humphries Steve E
Reductions in all-cause, cancer, and coronary mortality in statin-treated patients with heterozygous familial hypercholesterolaemia: a prospective registry study.
European heart journal 2008;29(21):2625-33.
2008: Ozsait Bilge; Kömürcü Bayrak Evrim; Poda Mehves; Can Günay; Hergenç Gülay; Onat Altan; Humphries Steve E; Erginel Unaltuna Nihan
CETP TaqIB polymorphism in Turkish adults: association with dyslipidemia and metabolic syndrome.
Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology 2008;8(5):324-30.
2008: Dorfmeister B; Zeng W W; Dichlberger A; Nilsson S K; Schaap F G; Hubacek J A; Merkel M; Cooper J A; Lookene A; Putt W; Whittall R; Lee P J; Lins L; Delsaux N; Nierman M; Kuivenhoven J A; Kastelein J J P; Vrablik M; Olivecrona G; Schneider W J; Heeren J; Humphries S E; Talmud P J
Effects of six APOA5 variants, identified in patients with severe hypertriglyceridemia, on in vitro lipoprotein lipase activity and receptor binding.
Arteriosclerosis, thrombosis, and vascular biology 2008;28(10):1866-71.
2008: Stephens Jeffrey W; Bain Stephen C; Humphries Steve E
Gene-environment interaction and oxidative stress in cardiovascular disease.
Atherosclerosis 2008;200(2):229-38.
2008: Elkeles Robert S; Godsland Ian F; Feher Michael D; Rubens Michael B; Roughton Michael; Nugara Fiona; Humphries Steve E; Richmond William; Flather Marcus D;
Coronary calcium measurement improves prediction of cardiovascular events in asymptomatic patients with type 2 diabetes: the PREDICT study.
European heart journal 2008;29(18):2244-51.
2008: Brunner Eric J; Kivimäki Mika; Witte Daniel R; Lawlor Debbie A; Davey Smith George; Cooper Jackie A; Miller Michelle; Lowe Gordon D O; Rumley Ann; Casas Juan P; Shah Tina; Humphries Steve E; Hingorani Aroon D; Marmot Michael G; Timpson Nicholas J; Kumari Meena
Inflammation, insulin resistance, and diabetes--Mendelian randomization using CRP haplotypes points upstream.
PLoS medicine 2008;5(8):e155.
2008: Humphries Steve E; Norbury Gail; Leigh Sarah; Hadfield S Gaye; Nair Devikair
What is the clinical utility of DNA testing in patients with familial hypercholesterolaemia?
Current opinion in lipidology 2008;19(4):362-8.
2008: Salpea Klelia D; Nicaud Viviane; Tiret Laurence; Talmud Philippa J; Humphries Steve E;
The association of telomere length with paternal history of premature myocardial infarction in the European Atherosclerosis Research Study II.
Journal of molecular medicine (Berlin, Germany) 2008;86(7):815-24.
2008: Palmen Jutta; Smith Andrew J P; Dorfmeister Birgit; Putt Wendy; Humphries Steve E; Talmud Philippa J
The functional interaction on in vitro gene expression of APOA5 SNPs, defining haplotype APOA52, and their paradoxical association with plasma triglyceride but not plasma apoAV levels.
Biochimica et biophysica acta 2008;1782(7-8):447-52.
2008: Humphries Steve E
The pain is that we will have to increase the rejection rate, from its current 60-65% to nearer 75-80%.
Atherosclerosis 2008;199(1):1-2.
2008: Leigh S E A; Foster A H; Whittall R A; Hubbart C S; Humphries S E
Update and analysis of the University College London low density lipoprotein receptor familial hypercholesterolemia database.
Annals of human genetics 2008;72(Pt 4):485-98.
2008: Humphries Steve E; Hadfield Gaye
Identifying patients with familial hypercholesterolaemia in primary care.
Heart (British Cardiac Society) 2008;94(6):695-6.
2008: Sanderson Saskia C; Humphries Steve E; Hubbart Christina; Hughes Eluned; Jarvis Martin J; Wardle Jane
Psychological and behavioural impact of genetic testing smokers for lung cancer risk: a phase II exploratory trial.
Journal of health psychology 2008;13(4):481-94.
2008: Samuel J M; Kelberman D; Smith A J P; Humphries S E; Woo P
Identification of a novel regulatory region in the interleukin-6 gene promoter.
Cytokine 2008;42(2):256-64.
2008: Smith Andrew J P; D'Aiuto Francesco; Palmen Jutta; Cooper Jackie A; Samuel Jane; Thompson Simon; Sanders Julie; Donos Nikos; Nibali Luigi; Brull David; Woo Pat; Humphries Steve E
Association of serum interleukin-6 concentration with a functional IL6 -6331T>C polymorphism.
Clinical chemistry 2008;54(5):841-50.
2008: Verzilli Claudio; Shah Tina; Casas Juan P; Chapman Juliet; Sandhu Manjinder; Debenham Sally L; Boekholdt Matthijs S; Khaw Kay Tee; Wareham Nicholas J; Judson Richard; Benjamin Emelia J; Kathiresan Sekar; Larson Martin G; Rong Jian; Sofat Reecha; Humphries Steve E; Smeeth Liam; Cavalleri Gianpiero; Whittaker John C; Hingorani Aroon D
Bayesian meta-analysis of genetic association studies with different sets of markers.
American journal of human genetics 2008;82(4):859-72.
2008: Humphries Steve E; Yiannakouris Nikos; Talmud Philippa J
Cardiovascular disease risk prediction using genetic information (gene scores): is it really informative?
Current opinion in lipidology 2008;19(2):128-32.
2008: Talmud Philippa J; Cooper Jackie A; Palmen Jutta; Lovering Ruth; Drenos Fotios; Hingorani Aroon D; Humphries Steve E
Chromosome 9p21.3 coronary heart disease locus genotype and prospective risk of CHD in healthy middle-aged men.
Clinical chemistry 2008;54(3):467-74.
2008: Hopkinson Nicholas S; Li Ka Wah; Kehoe Anthony; Humphries Steve E; Roughton Michael; Moxham John; Montgomery Hugh; Polkey Michael I
Vitamin D receptor genotypes influence quadriceps strength in chronic obstructive pulmonary disease.
The American journal of clinical nutrition 2008;87(2):385-90.
2008: Muthumala Amal; Drenos Fotios; Elliott Perry M; Humphries Steve E
Role of beta adrenergic receptor polymorphisms in heart failure: systematic review and meta-analysis.
European journal of heart failure : journal of the Working Group on Heart Failure of the European Society of Cardiology 2008;10(1):3-13.
2008: Thompson A R; Drenos F; Hafez H; Humphries S E
Candidate gene association studies in abdominal aortic aneurysm disease: a review and meta-analysis.
European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery 2008;35(1):19-30.
2008: Stephens Jeffrey W; Dhamrait Sukhbir S; Mani Ali R; Acharya Jayshree; Moore Kevin; Hurel Steven J; Humphries Steve E
Interaction between the uncoupling protein 2 -866G>A gene variant and cigarette smoking to increase oxidative stress in subjects with diabetes.
Nutrition, metabolism, and cardiovascular diseases : NMCD 2008;18(1):7-14.
2008: Sanderson Saskia C; Wardle Jane; Humphries Steve E
Public health genomics and genetic test evaluation: the challenge of conducting behavioural research on the utility of lifestyle-genetic tests.
Journal of nutrigenetics and nutrigenomics 2008;1(5):224-31.
2008: Wierzbicki Anthony S; Humphries Steve E; Minhas Rubin;
Familial hypercholesterolaemia: summary of NICE guidance.
BMJ (Clinical research ed.) 2008;337():a1095.
2008: Kivimäki Mika; Lawlor Debbie A; Smith George Davey; Kumari Meena; Donald Ann; Britton Annie; Casas Juan P; Shah Tina; Brunner Eric; Timpson Nicholas J; Halcox Julian P J; Miller Michelle A; Humphries Steve E; Deanfield John; Marmot Michael G; Hingorani Aroon D
Does high C-reactive protein concentration increase atherosclerosis? The Whitehall II Study.
PloS one 2008;3(8):e3013.
2008: Hosseini-Khalili Ali Reza; Thompson Julian; Kehoe Anthony; Hopkinson Nicholas S; Khoshbaten A; Soroush Mohammad Reza; Humphries Steve E; Montgomery Hugh; Ghanei Mostafa
Angiotensin-converting enzyme genotype and late respiratory complications of mustard gas exposure.
BMC pulmonary medicine 2008;8():15.
2008: Starr Brian; Hadfield S Gaye; Hutten Barbara A; Lansberg Peter J; Leren Trond P; Damgaard Dorte; Neil H Andrew W; Humphries Steve E
Development of sensitive and specific age- and gender-specific low-density lipoprotein cholesterol cutoffs for diagnosis of first-degree relatives with familial hypercholesterolaemia in cascade testing.
Clinical chemistry and laboratory medicine : CCLM / FESCC 2008;46(6):791-803.
2008: Komurcu-Bayrak Evrim; Onat Altan; Poda Mehves; Humphries Steve E; Palmen Jutta; Guclu Filiz; Can Gunay; Erginel-Unaltuna Nihan
Gender-modulated impact of apolipoprotein A5 gene (APOA5) -1131T>C and c.56C>G polymorphisms on lipids, dyslipidemia and metabolic syndrome in Turkish adults.
Clinical chemistry and laboratory medicine : CCLM / FESCC 2008;46(6):778-84.
2007: Thompson Simon R; McCaskie Pamela A; Beilby John P; Hung Joseph; Jennens Michelle; Chapman Caroline; Thompson Peter; Humphries Steve E
IL18 haplotypes are associated with serum IL-18 concentrations in a population-based study and a cohort of individuals with premature coronary heart disease.
Clinical chemistry 2007;53(12):2078-85.
2007: Thompson Simon R; Novick Daniela; Stock Carmel J; Sanders Julie; Brull David; Cooper Jackie; Woo Patricia; Miller George; Rubinstein Menachem; Humphries Steve E
Free Interleukin (IL)-18 levels, and the impact of IL18 and IL18BP genetic variation, in CHD patients and healthy men.
Arteriosclerosis, thrombosis, and vascular biology 2007;27(12):2743-9.
2007: Muthumala Amal; Gable David R; Palmen Jutta; Cooper Jackie A; Stephens Jeffrey W; Miller George J; Humphries Steve E
Is the influence of variation in the ACE gene on the prospective risk of Type 2 diabetes in middle-aged men modified by obesity?
Clinical science (London, England : 1979) 2007;113(12):467-72.
2007: Scartezini Marileia; Hubbart Christina; Whittall Ros A; Cooper Jackie A; Neil Andrew H W; Humphries Steve E
The PCSK9 gene R46L variant is associated with lower plasma lipid levels and cardiovascular risk in healthy U.K. men.
Clinical science (London, England : 1979) 2007;113(11):435-41.
2007: Smith Andrew J P; Ahmed Fayha; Nair Devi; Whittall Ros; Wang Darrell; Taylor Alison; Norbury Gail; Humphries Steve E
A functional mutation in the LDLR promoter (-139C>G) in a patient with familial hypercholesterolemia.
European journal of human genetics : EJHG 2007;15(11):1186-9.
2007: Hadfield Gaye S; Humphries Steve E
Familial hypercholesterolaemia: Cascade testing is tried and tested and cost effective.
BMJ (Clinical research ed.) 2007;335(7622):683.
2007: Hall Ruth; Saukko Paula M; Evans Philip H; Qureshi Nadeem; Humphries Steve E
Assessing family history of heart disease in primary care consultations: a qualitative study.
Family practice 2007;24(5):435-42.
2007: Morange P E; Saut N; Alessi M C; Yudkin J S; Margaglione M; Di Minno G; Hamsten A; Humphries S E; Tregouet D A; Juhan-Vague I
Association of plasminogen activator inhibitor (PAI)-1 (SERPINE1) SNPs with myocardial infarction, plasma PAI-1, and metabolic parameters: the HIFMECH study.
Arteriosclerosis, thrombosis, and vascular biology 2007;27(10):2250-7.
2007: Drenos F; Whittaker J C; Humphries S E
The use of meta-analysis risk estimates for candidate genes in combination to predict coronary heart disease risk.
Annals of human genetics 2007;71(Pt 5):611-9.
2007: Muthumala Amal; Montgomery Hugh; Palmen Jutta; Cooper Jackie A; Humphries Steve E
Angiotensin-converting enzyme genotype interacts with systolic blood pressure to determine coronary heart disease risk in healthy middle-aged men.
Hypertension 2007;50(2):348-53.
2007: Komurcu-Bayrak Evrim; Onat Altan; Poda Mehves; Humphries Steve E; Acharya Jayshree; Hergenc Gülay; Coban Neslihan; Can Gunay; Erginel-Unaltuna Nihan
The S447X variant of lipoprotein lipase gene is associated with metabolic syndrome and lipid levels among Turks.
Clinica chimica acta; international journal of clinical chemistry 2007;383(1-2):110-5.
2007: Payne John R; James Laurence E; Eleftheriou Kyriacos I; Hawe Emma; Mann Jack; Stronge Alex; Banham Karen; World Michael; Humphries Steve E; Pennell Dudley J; Montgomery Hugh E
The association of left ventricular mass with blood pressure, cigarette smoking and alcohol consumption; data from the LARGE Heart study.
International journal of cardiology 2007;120(1):52-8.
2007: Gable D R; Matin J; Whittall R; Cakmak H; Li Ka Wah; Cooper J; Miller G J; Humphries S E;
Common adiponectin gene variants show different effects on risk of cardiovascular disease and type 2 diabetes in European subjects.
Annals of human genetics 2007;71(Pt 4):453-66.
2007: Wootton Peter T E; Arora Nupur L; Drenos Fotios; Thompson Simon R; Cooper Jackie A; Stephens Jeffrey W; Hurel Steven J; Hurt-Camejo Eva; Wiklund Olov; Humphries Steve E; Talmud Philippa J
Tagging SNP haplotype analysis of the secretory PLA2-V gene, PLA2G5, shows strong association with LDL and oxLDL levels, suggesting functional distinction from sPLA2-IIA: results from the UDACS study.
Human molecular genetics 2007;16(12):1437-44.
2007: Taylor A; Tabrah S; Wang D; Sozen M; Duxbury N; Whittall R; Humphries S E; Norbury G
Multiplex ARMS analysis to detect 13 common mutations in familial hypercholesterolaemia.
Clinical genetics 2007;71(6):561-8.
2007: Talmud Philippa J; Flavell David M; Alfakih Khaled; Cooper Jackie A; Balmforth Anthony J; Sivananthan Mohan; Montgomery Hugh E; Hall Alistair S; Humphries Steve E
The lipoprotein lipase gene serine 447 stop variant influences hypertension-induced left ventricular hypertrophy and risk of coronary heart disease.
Clinical science (London, England : 1979) 2007;112(12):617-24.
2007: Wong Wai-Man R; Gerry Andrew B; Putt Wendy; Roberts Jane L; Weinberg Richard B; Humphries Steve E; Leake David S; Talmud Philippa J
Common variants of apolipoprotein A-IV differ in their ability to inhibit low density lipoprotein oxidation.
Atherosclerosis 2007;192(2):266-74.
2007: Thompson Simon R; Sanders Julie; Stephens Jeffrey W; Miller George J; Humphries Steve E
A common interleukin 18 haplotype is associated with higher body mass index in subjects with diabetes and coronary heart disease.
Metabolism: clinical and experimental 2007;56(5):662-9.
2007: Stephens Jeffrey W; Hurel Steven J; Lowe Gordon D O; Rumley Ann; Humphries Steve E
Association between plasma IL-6, the IL6 -174G>C gene variant and the metabolic syndrome in type 2 diabetes mellitus.
Molecular genetics and metabolism 2007;90(4):422-8.
2007: Hothi Daljit K; Bass Paul; Morgan Mary; Acharya Jayshree; Humphries Steve E; Gilbert Rodney D
Acute renal failure in a patient with paroxysmal cold hemoglobinuria.
Pediatric nephrology (Berlin, Germany) 2007;22(4):593-6.
2007: Dorfmeister Birgit; Cooper Jackie A; Stephens Jeffrey W; Ireland Helen; Hurel Steven J; Humphries Steve E; Talmud Philippa J
The effect of APOA5 and APOC3 variants on lipid parameters in European Whites, Indian Asians and Afro-Caribbeans with type 2 diabetes.
Biochimica et biophysica acta 2007;1772(3):355-63.
2007: Hindmarsh P C; Rodeck C H; Humphries S E
Polymorphisms in the angiotensin converting enzyme gene and growth in the first year of life.
Annals of human genetics 2007;71(Pt 2):176-84.
2007: Harding D R; Humphries S E; Whitelaw A; Marlow N; Montgomery H E
Cognitive outcome and cyclo-oxygenase-2 gene (-765 G/C) variation in the preterm infant.
Archives of disease in childhood. Fetal and neonatal edition 2007;92(2):F108-12.
2007: Payne J R; Dhamrait S S; Gohlke P; Cooper J; Scott R A; Pitsiladis Y P; Humphries S E; Rayner B; Montgomery H E
The impact of ACE genotype on serum ACE activity in a black South African male population.
Annals of human genetics 2007;71(Pt 1):1-7.
2007: Wootton Peter T E; Flavell David M; Montgomery Hugh E; World Mike; Humphries Steve E; Talmud Philippa J
Lipoprotein-associated phospholipase A2 A379V variant is associated with body composition changes in response to exercise training.
Nutrition, metabolism, and cardiovascular diseases : NMCD 2007;17(1):24-31.
2007: Humphries Steve E; Cooper Jackie A; Talmud Philippa J; Miller George J
Candidate gene genotypes, along with conventional risk factor assessment, improve estimation of coronary heart disease risk in healthy UK men.
Clinical chemistry 2007;53(1):8-16.
2007: Drenos F; Miller G J; Humphries S E
Increase of plasma fibrinogen levels and variability with age in a sample of middle aged healthy men.
Annals of human genetics 2007;71(Pt 1):43-53.
2007: Shamaei-Tousi Alireza; Steptoe Andrew; O'Donnell Katie; Palmen Jutta; Stephens Jeffrey W; Hurel Steven J; Marmot Michael; Homer Karen; D'Aiuto Francesco; Coates Anthony R M; Humphries Steve E; Henderson Brian
Plasma heat shock protein 60 and cardiovascular disease risk: the role of psychosocial, genetic, and biological factors.
Cell stress & chaperones 2007;12(4):384-92.
2007: Gable David; Sanderson Saskia C; Humphries Steve E
Genotypes, obesity and type 2 diabetes--can genetic information motivate weight loss? A review.
Clinical chemistry and laboratory medicine : CCLM / FESCC 2007;45(3):301-8.
2006: Humphries Steve E; Gable David; Cooper Jackie A; Ireland Helen; Stephens Jeffrey W; Hurel Steven J; Li Ka Wah; Palmen Jutta; Miller Michelle A; Cappuccio Francesco P; Elkeles Robert; Godsland Ian; Miller George J; Talmud Philippa J
Common variants in the TCF7L2 gene and predisposition to type 2 diabetes in UK European Whites, Indian Asians and Afro-Caribbean men and women.
Journal of molecular medicine (Berlin, Germany) 2006;84(12):1005-14.
2006: Sanders Julie; Harris Joanna; Cooper Jackie; Gohlke Peter; Humphries Steve E; Montgomery Hugh; Woods David R
Lack of change in serum angiotensin-converting enzyme activity during the menstrual cycle.
Journal of the renin-angiotensin-aldosterone system : JRAAS 2006;7(4):231-5.
2006: Payne J R; Eleftheriou K I; James L E; Hawe E; Mann J; Stronge A; Kotwinski P; World M; Humphries S E; Pennell D J; Montgomery H E
Left ventricular growth response to exercise and cigarette smoking: data from LARGE Heart.
Heart (British Cardiac Society) 2006;92(12):1784-8.
2006: Muthumala Amal; Cooper Jackie; Humphries Steve E;
European differences in the association between ACE I/D polymorphism and incidence of MI may be explained by gene-lipid interaction.
Atherosclerosis 2006;189(2):474-7.
2006: Vieira José Ricardo S; Whittall Ros A; Cooper Jackie A; Miller George J; Humphries Steve E
The A370T variant (StuI polymorphism) in the LDL receptor gene is not associated with plasma lipid levels or cardiovascular risk in UK men.
Annals of human genetics 2006;70(Pt 6):697-704.
2006: Casas Juan P; Cavalleri Gianpiero L; Bautista Leonelo E; Smeeth Liam; Humphries Steve E; Hingorani Aroon D
Endothelial nitric oxide synthase gene polymorphisms and cardiovascular disease: a HuGE review.
American journal of epidemiology 2006;164(10):921-35.
2006: Wootton P T E; Stephens J W; Hurel S J; Durand H; Cooper J; Ninio E; Humphries S E; Talmud P J
Lp-PLA2 activity and PLA2G7 A379V genotype in patients with diabetes mellitus.
Atherosclerosis 2006;189(1):149-56.
2006: Talmud P J; Cooper J A; Hattori H; Miller I P; Miller G J; Humphries S E
The apolipoprotein A-V genotype and plasma apolipoprotein A-V and triglyceride levels: prospective risk of type 2 diabetes. Results from the Northwick Park Heart Study II.
Diabetologia 2006;49(10):2337-40.
2006: Gable D R; Hurel S J; Humphries S E
Adiponectin and its gene variants as risk factors for insulin resistance, the metabolic syndrome and cardiovascular disease.
Atherosclerosis 2006;188(2):231-44.
2006: Stephens Jeffrey W; Dhamrait Sukhbir S; Acharya Jayshree; Humphries Steve E; Hurel Steven J
A common variant in the ACE gene is associated with peripheral neuropathy in women with type 2 diabetes mellitus.
Journal of diabetes and its complications 2006;20(5):317-21.
2006: Vaessen Stefan F C; Schaap Frank G; Kuivenhoven Jan-Albert; Groen Albert K; Hutten Barbara A; Boekholdt S Matthijs; Hattori Hiroaki; Sandhu Manjinder S; Bingham Sheila A; Luben Robert; Palmen Jutta A; Wareham Nicholas J; Humphries Steve E; Kastelein John J P; Talmud Philippa J; Khaw Kay-Tee
Apolipoprotein A-V, triglycerides and risk of coronary artery disease: the prospective Epic-Norfolk Population Study.
Journal of lipid research 2006;47(9):2064-70.
2006: Meade Tom W; Humphries Steve E; De Stavola Bianca L
Commentary: fibrinogen and coronary heart disease--test of causality by 'Mendelian' randomization by Keavney et al.
International journal of epidemiology 2006;35(4):944-7.
2006: Casas Juan P; Shah Tina; Cooper Jackie; Hawe Emma; McMahon Alex D; Gaffney Dairena; Packard Christopher J; O'Reilly Denis S; Juhan-Vague Irene; Yudkin John S; Tremoli Elena; Margaglione Maurizio; Di Minno Giovanni; Hamsten Anders; Kooistra Teake; Stephens Jeffrey W; Hurel Steven J; Livingstone Shona; Colhoun Helen M; Miller George J; Bautista Leonelo E; Meade Tom; Sattar Naveed; Humphries Steve E; Hingorani Aroon D
Insight into the nature of the CRP-coronary event association using Mendelian randomization.
International journal of epidemiology 2006;35(4):922-31.
2006: Aitken Wendy A E; Chisholm Alexandra W-A H; Duncan Ashley W; Harper Michelle J; Humphries Steve E; Mann Jim I; Murray Skeaff C; Sutherland Wayne H F; Wallace Alison J; Williams Sheila M
Variation in the cholesteryl ester transfer protein (CETP) gene does not influence individual plasma cholesterol response to changes in the nature of dietary fat.
Nutrition, metabolism, and cardiovascular diseases : NMCD 2006;16(5):353-63.
2006: Shamaei-Tousi Alireza; Stephens Jeffrey W; Bin Ren; Cooper Jacqueline A; Steptoe Andrew; Coates Anthony R M; Henderson Brian; Humphries Steve E
Association between plasma levels of heat shock protein 60 and cardiovascular disease in patients with diabetes mellitus.
European heart journal 2006;27(13):1565-70.
2006: Gable David R; Stephens Jefferey W; Cooper Jackie A; Miller George J; Humphries Steve E
Variation in the UCP2-UCP3 gene cluster predicts the development of type 2 diabetes in healthy middle-aged men.
Diabetes 2006;55(5):1504-11.
2006: Casas Juan P; Cooper Jackie; Miller George J; Hingorani Aroon D; Humphries Steve E
Investigating the genetic determinants of cardiovascular disease using candidate genes and meta-analysis of association studies.
Annals of human genetics 2006;70(Pt 2):145-69.
2006: Shearman Amanda M; Cooper Jackie A; Kotwinski Paul J; Miller George J; Humphries Steve E; Ardlie Kristin G; Jordan Barbara; Irenze Kathryn; Lunetta Kathryn L; Schuit Stephanie C E; Uitterlinden André G; Pols Huibert A P; Demissie Serkalem; Cupples L Adrienne; Mendelsohn Michael E; Levy Daniel; Housman David E
Estrogen receptor alpha gene variation is associated with risk of myocardial infarction in more than seven thousand men from five cohorts.
Circulation research 2006;98(5):590-2.
2006: Humphries Steve E; Cranston Treena; Allen Marcus; Middleton-Price Helen; Fernandez Maryam C; Senior Victoria; Hawe Emma; Iversen Andrew; Wray Richard; Crook Martin A; Wierzbicki Anthony S
Mutational analysis in UK patients with a clinical diagnosis of familial hypercholesterolaemia: relationship with plasma lipid traits, heart disease risk and utility in relative tracing.
Journal of molecular medicine (Berlin, Germany) 2006;84(3):203-14.
2006: Stephens Jeffrey W; Gable David R; Hurel Steven J; Miller George J; Cooper Jackie A; Humphries Steve E
Increased plasma markers of oxidative stress are associated with coronary heart disease in males with diabetes mellitus and with 10-year risk in a prospective sample of males.
Clinical chemistry 2006;52(3):446-52.
2006: Flavell David M; Wootton Peter T E; Myerson Saul G; World Michael J; Pennell Dudley J; Humphries Steve E; Talmud Philippa J; Montgomery Hugh E
Variation in the lipoprotein lipase gene influences exercise-induced left ventricular growth.
Journal of molecular medicine (Berlin, Germany) 2006;84(2):126-31.
2006: Humphries Steve E; Hingorani Aroon
Pharmacogenetics: progress, pitfalls and clinical potential for coronary heart disease.
Vascular pharmacology 2006;44(2):119-25.
2006: Hayek Tony; Stephens Jeffrey W; Hubbart Christina S; Acharya Jayshree; Caslake Muriel J; Hawe Emma; Miller George J; Hurel Steven J; Humphries Steve E
A common variant in the glutathione S transferase gene is associated with elevated markers of inflammation and lipid peroxidation in subjects with diabetes mellitus.
Atherosclerosis 2006;184(2):404-12.
2006: Wootton Peter T E; Drenos Fotios; Cooper Jackie A; Thompson Simon R; Stephens Jeffrey W; Hurt-Camejo Eva; Wiklund Olov; Humphries Steve E; Talmud Philippa J
Tagging-SNP haplotype analysis of the secretory PLA2IIa gene PLA2G2A shows strong association with serum levels of sPLA2IIa: results from the UDACS study.
Human molecular genetics 2006;15(2):355-61.
2005: Ireland H; Konstantoulas C J; Cooper J A; Hawe E; Humphries S E; Mather H; Goodall A H; Hogwood J; Juhan-Vague I; Yudkin J S; di Minno G; Margaglione M; Hamsten A; Miller G J; Bauer K A; Kim Y T; Stearns-Kurosawa D J; Kurosawa S
EPCR Ser219Gly: elevated sEPCR, prothrombin F1+2, risk for coronary heart disease, and increased sEPCR shedding in vitro.
Atherosclerosis 2005;183(2):283-92.
2005: Talmud P J; Stephens J W; Hawe E; Demissie S; Cupples L A; Hurel S J; Humphries S E; Ordovas J M
The significant increase in cardiovascular disease risk in APOEepsilon4 carriers is evident only in men who smoke: potential relationship between reduced antioxidant status and ApoE4.
Annals of human genetics 2005;69(Pt 6):613-22.
2005: Shearman Amanda M; Cooper Jackie A; Kotwinski Paul J; Humphries Steve E; Mendelsohn Michael E; Housman David E; Miller George J
Estrogen receptor alpha gene variation and the risk of stroke.
Stroke; a journal of cerebral circulation 2005;36(10):2281-2.
2005: Li Ping; Elrayess Mohamed A; Gomma Abuzeid H; Palmen Jutta; Hawe Emma; Fox Kim M; Humphries Steve E
The microsatellite polymorphism of heme oxygenase-1 is associated with baseline plasma IL-6 level but not with restenosis after coronary in-stenting.
Chinese medical journal 2005;118(18):1525-32.
2005: Hadfield S Gaye; Humphries Steve E
Implementation of cascade testing for the detection of familial hypercholesterolaemia.
Current opinion in lipidology 2005;16(4):428-33.
2005: Talmud Philippa J; Palmen Jutta; Putt Wendy; Lins Laurence; Humphries Steve E
Determination of the functionality of common APOA5 polymorphisms.
The Journal of biological chemistry 2005;280(31):28215-20.
2005: Harding David; Brull David; Humphries Steve E; Whitelaw Andrew; Montgomery Hugh; Marlow Neil
Variation in the interleukin-6 gene is associated with impaired cognitive development in children born prematurely: a preliminary study.
Pediatric research 2005;58(1):117-20.
2005: Cooper Jackie A; Miller George J; Humphries Steve E
A comparison of the PROCAM and Framingham point-scoring systems for estimation of individual risk of coronary heart disease in the Second Northwick Park Heart Study.
Atherosclerosis 2005;181(1):93-100.
2005: Waterworth Dawn M; Jansen Hans; Nicaud Viviane; Humphries Steve E; Talmud Philippa J;
Interaction between insulin (VNTR) and hepatic lipase (LIPC-514C>T) variants on the response to an oral glucose tolerance test in the EARSII group of young healthy men.
Biochimica et biophysica acta 2005;1740(3):375-81.
2005: Younis Jenan; Cooper Jackie A; Miller George J; Humphries Steve E; Talmud Philippa J
Genetic variation in alcohol dehydrogenase 1C and the beneficial effect of alcohol intake on coronary heart disease risk in the Second Northwick Park Heart Study.
Atherosclerosis 2005;180(2):225-32.
2005: Fife M S; Ogilvie E M; Kelberman D; Samuel J; Gutierrez A; Humphries S E; Woo P
Novel IL-6 haplotypes and disease association.
Genes and immunity 2005;6(4):367-70.
2005: Sözen M Mert; Whittall Ros; Oner Cihan; Tokatli Aysegül; Kalkanoglu H Serap; Dursun Ali; Coskun Turgay; Oner Reyhan; Humphries Steve E
The molecular basis of familial hypercholesterolaemia in Turkish patients.
Atherosclerosis 2005;180(1):63-71.
2005: D'Aiuto Francesco; Casas Juan P; Shah Tina; Humphries Steve E; Hingorani Aroon D; Tonetti Maurizio S
C-reactive protein (+1444C>T) polymorphism influences CRP response following a moderate inflammatory stimulus.
Atherosclerosis 2005;179(2):413-7.
2005: Morange P E; Saut N; Alessi M C; Frere C; Hawe E; Yudkin J S; Tremoli E; Margaglione M; Di Minno G; Hamsten A; Humphries S E; Juhan-Vague I;
Interaction between the C-260T polymorphism of the CD14 gene and the plasma IL-6 concentration on the risk of myocardial infarction: the HIFMECH study.
Atherosclerosis 2005;179(2):317-23.
2005: Morgan Laleh; Humphries Steve E
The genetics of stroke.
Current opinion in lipidology 2005;16(2):193-9.
2005: Newson Ainsley J; Humphries Steve E
Cascade testing in familial hypercholesterolaemia: how should family members be contacted?
European journal of human genetics : EJHG 2005;13(4):401-8.
2005: Eriksson-Berg Margita; Deguchi Hiroyuki; Hawe Emma; Scanavini Daniela; Orth-Gomér Kristina; Schenck-Gustafsson Karin; Humphries Steve E; Silveira Angela; Hamsten Anders
Influence of factor VII gene polymorphisms and environmental factors on plasma coagulation factor VII concentrations in middle-aged women with and without manifest coronary heart disease.
Thrombosis and haemostasis 2005;93(2):351-8.
2005: Flavell David M; Ireland Helen; Stephens Jeffrey W; Hawe Emma; Acharya Jay; Mather Hugh; Hurel Steven J; Humphries Steve E
Peroxisome proliferator-activated receptor alpha gene variation influences age of onset and progression of type 2 diabetes.
Diabetes 2005;54(2):582-6.
2005: Stephens Jeffrey W; Dhamrait Sukhbir S; Cooper Jaqueline A; Acharya Jayshree; Miller George J; Hurel Steven J; Humphries Steve E
The D allele of the ACE I/D common gene variant is associated with Type 2 diabetes mellitus in Caucasian subjects.
Molecular genetics and metabolism 2005;84(1):83-9.
2005: Stephens Jeffrey W; Sozen M Mert; Whittall Ros A; Caslake Muriel J; Bedford Dorothy; Acharya Jayshree; Hurel Steven J; Humphries Steve E
Three novel mutations in the apolipoprotein E gene in a sample of individuals with type 2 diabetes mellitus.
Clinical chemistry 2005;51(1):119-24.
2004: Foucher Christelle; Rattier Stephanie; Flavell David M; Talmud Philippa J; Humphries Steve E; Kastelein John J P; Ayyobi Amir; Pimstone Simon; Frohlich Jiri; Ansquer Jean-Claude; Steiner George;
Response to micronized fenofibrate treatment is associated with the peroxisome-proliferator-activated receptors alpha G/C intron7 polymorphism in subjects with type 2 diabetes.
Pharmacogenetics 2004;14(12):823-9.
2004: Stephens Jeffrey W; Ambler Gareth; Vallance Patrick; Betteridge D John; Humphries Steve E; Hurel Steven J
Cardiovascular risk and diabetes. Are the methods of risk prediction satisfactory?
European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology 2004;11(6):521-8.
2004: Sozen Mert; Whittall Roslyn; Humphries Steve E
Mutation detection in patients with familial hypercholesterolaemia using heteroduplex and single strand conformation polymorphism analysis by capillary electrophoresis.
Atherosclerosis. Supplements 2004;5(5):7-11.
2004: Ireland Helen; Miller George J; Webb Karen E; Cooper Jackie A; Humphries Steve E
The factor VII activating protease G511E (Marburg) variant and cardiovascular risk.
Thrombosis and haemostasis 2004;92(5):986-92.
2004: Elrayess Mohamed A; Webb Karen E; Bellingan Geoff J; Whittall Ros A; Kabir Jahangir; Hawe Emma; Syvänne Mikko; Taskinen Marja-Riitta; Frick M Heikki; Nieminen Markku S; Kesäniemi Y Antero; Pasternack Amos; Miller George J; Humphries Steve E
R643G polymorphism in PECAM-1 influences transendothelial migration of monocytes and is associated with progression of CHD and CHD events.
Atherosclerosis 2004;177(1):127-35.
2004: Talmud Philippa J; Lewis Sarah J; Hawe Emma; Martin Steve; Acharya Jayshree; Marmot Michael G; Humphries Steve E; Brunner Eric J
No APOEepsilon4 effect on coronary heart disease risk in a cohort with low smoking prevalence: the Whitehall II study.
Atherosclerosis 2004;177(1):105-12.
2004: Konstantoulas C J; Cooper J; Warnock G; Miller G J; Humphries S E; Ireland H
A combination of two common thrombomodulin gene variants (-1208-1209TTdelTT and A455V) influence risk of coronary heart disease: a prospective study in men.
Atherosclerosis 2004;177(1):97-104.
2004: Harding David R; Dhamrait Sukbhir; Whitelaw Andrew; Humphries Steve E; Marlow Neil; Montgomery Hugh E
Does interleukin-6 genotype influence cerebral injury or developmental progress after preterm birth?
Pediatrics 2004;114(4):941-7.
2004: Hutter Carolyn M; Austin Melissa A; Humphries Steve E
Familial hypercholesterolemia, peripheral arterial disease, and stroke: a HuGE minireview.
American journal of epidemiology 2004;160(5):430-5.
2004: Austin Melissa A; Hutter Carolyn M; Zimmern Ron L; Humphries Steve E
Familial hypercholesterolemia and coronary heart disease: a HuGE association review.
American journal of epidemiology 2004;160(5):421-9.
2004: Austin Melissa A; Hutter Carolyn M; Zimmern Ron L; Humphries Steve E
Genetic causes of monogenic heterozygous familial hypercholesterolemia: a HuGE prevalence review.
American journal of epidemiology 2004;160(5):407-20.
2004: Sanderson Saskia C; Wardle Jane; Jarvis Martin J; Humphries Steve E
Public interest in genetic testing for susceptibility to heart disease and cancer: a population-based survey in the UK.
Preventive medicine 2004;39(3):458-64.
2004: Wong Wai-Man R; Stephens Jeffrey W; Acharya Jayshree; Hurel Steven J; Humphries Steve E; Talmud Philippa J
The APOA4 T347S variant is associated with reduced plasma TAOS in subjects with diabetes mellitus and cardiovascular disease.
Journal of lipid research 2004;45(8):1565-71.
2004: Putt Wendy; Palmen Jutta; Nicaud Viviane; Tregouet David-Alexandre; Tahri-Daizadeh Nadia; Flavell David M; Humphries Steve E; Talmud Philippa J;
Variation in USF1 shows haplotype effects, gene : gene and gene : environment associations with glucose and lipid parameters in the European Atherosclerosis Research Study II.
Human molecular genetics 2004;13(15):1587-97.
2004: Yudkin J S; Juhan-Vague I; Hawe E; Humphries S E; di Minno G; Margaglione M; Tremoli E; Kooistra T; Morange P E; Lundman P; Mohamed-Ali V; Hamsten A;
Low-grade inflammation may play a role in the etiology of the metabolic syndrome in patients with coronary heart disease: the HIFMECH study.
Metabolism: clinical and experimental 2004;53(7):852-7.
2004: Marteau Theresa; Senior Victoria; Humphries Steve E; Bobrow Martin; Cranston Treena; Crook Martin A; Day Lorna; Fernandez Maryam; Horne Rob; Iversen Andrew; Jackson Zoe; Lynas Jacqui; Middleton-Price Helen; Savine Richard; Sikorski Jim; Watson Melanie; Weinman John; Wierzbicki Anthony S; Wray Richard;
Psychological impact of genetic testing for familial hypercholesterolemia within a previously aware population: a randomized controlled trial.
American journal of medical genetics. Part A 2004;128A(3):285-93.
2004: Stephens Jeffrey W; Hurel Steven J; Cooper Jacqueline A; Acharya Jayshree; Miller George J; Humphries Steve E
A common functional variant in the interleukin-6 gene is associated with increased body mass index in subjects with type 2 diabetes mellitus.
Molecular genetics and metabolism 2004;82(2):180-6.
2004: James L; Onambele G; Woledge R; Skelton D; Woods D; Eleftheriou K; Hawe E; Humphries S E; Haddad F; Montgomery H
IL-6-174G/C genotype is associated with the bone mineral density response to oestrogen replacement therapy in post-menopausal women.
European journal of applied physiology 2004;92(1-2):227-30.
2004: Austin M A; Zhang C; Humphries S E; Chandler W L; Talmud P J; Edwards K L; Leonetti D L; McNeely M J; Fujimoto W Y
Heritability of C-reactive protein and association with apolipoprotein E genotypes in Japanese Americans.
Annals of human genetics 2004;68(Pt 3):179-88.
2004: Payne J R; Dhamrait S S; Toor I S; Cooper J; Jones A; Miller G J; Humphries S E; Montgomery H E
The -344T>C promoter variant of the gene for aldosterone synthase (CYP11B2) is not associated with cardiovascular risk in a prospective study of UK healthy men.
Atherosclerosis 2004;174(1):81-6.
2004: Sanders Thomas A B; de Grassi Tamara; Acharya Jayshree; Miller George J; Humphries Steve E
Postprandial variations in fibrinolytic activity in middle-aged men are modulated by plasminogen activator inhibitor I 4G-675/5G genotype but not by the fat content of a meal.
The American journal of clinical nutrition 2004;79(4):577-81.
2004: Theobald Hannah E; Chowienczyk Philip J; Whittall Ros; Humphries Steve E; Sanders Thomas A B
LDL cholesterol-raising effect of low-dose docosahexaenoic acid in middle-aged men and women.
The American journal of clinical nutrition 2004;79(4):558-63.
2004: Austin Melissa A; Edwards Karen L; McNeely Marguerite J; Chandler Wayne L; Leonetti Donna L; Talmud Philippa J; Humphries Steve E; Fujimoto Wilfred Y
Heritability of multivariate factors of the metabolic syndrome in nondiabetic Japanese americans.
Diabetes 2004;53(4):1166-9.
2004: Humphries Steve E; Morgan Laleh
Genetic risk factors for stroke and carotid atherosclerosis: insights into pathophysiology from candidate gene approaches.
Lancet neurology 2004;3(4):227-35.
2004: Talmud Philippa J; Martin Steve; Taskinen Marja-Riitta; Frick M Heikki; Nieminen Markku S; Kesäniemi Y Antero; Pasternack Amos; Humphries Steve E; Syvänne Mikko
APOA5 gene variants, lipoprotein particle distribution, and progression of coronary heart disease: results from the LOCAT study.
Journal of lipid research 2004;45(4):750-6.
2004: Humphries Steve E; Ridker Paul M; Talmud Philippa J
Genetic testing for cardiovascular disease susceptibility: a useful clinical management tool or possible misinformation?
Arteriosclerosis, thrombosis, and vascular biology 2004;24(4):628-36.
2004: Dhamrait Sukhbir S; Stephens Jeffrey W; Cooper Jacqueline A; Acharya Jayshree; Mani Ali R; Moore Kevin; Miller George J; Humphries Steve E; Hurel Steven J; Montgomery Hugh E
Cardiovascular risk in healthy men and markers of oxidative stress in diabetic men are associated with common variation in the gene for uncoupling protein 2.
European heart journal 2004;25(6):468-75.
2004: Casas Juan P; Bautista Leonelo E; Humphries Steve E; Hingorani Aroon D
Endothelial nitric oxide synthase genotype and ischemic heart disease: meta-analysis of 26 studies involving 23028 subjects.
Circulation 2004;109(11):1359-65.
2004: Stephens Jeffrey W; Hurel Steven J; Acharya Jayshree; Humphries Steve E
An interaction between the interleukin-6 -174G>C gene variant and urinary protein excretion influences plasma oxidative stress in subjects with type 2 diabetes.
Cardiovascular diabetology 2004;3():2.
2004: Kelberman Daniel; Fife Mark; Rockman Matthew V; Brull David J; Woo Patricia; Humphries Steve E
Analysis of common IL-6 promoter SNP variants and the AnTn tract in humans and primates and effects on plasma IL-6 levels following coronary artery bypass graft surgery.
Biochimica et biophysica acta 2004;1688(2):160-7.
2004: Konstantoulas Constantine; Hawe Emma; Saut Naomi; Yudkin John S; di Minno Giovanni; Margaglione Maurizio; Hamsten Anders; Humphries Steve E; Juhan-Vague Irene; Ireland Helen;
Common variants in the thrombomodulin gene as a risk for myocardial infarction in the north of Europe (HIFMECH Study).
Thrombosis and haemostasis 2004;91(3):628-30.
2004: Williams Alun G; Dhamrait Sukhbir S; Wootton Peter T E; Day Stephen H; Hawe Emma; Payne John R; Myerson Saul G; World Michael; Budgett Richard; Humphries Steve E; Montgomery Hugh E
Bradykinin receptor gene variant and human physical performance.
Journal of applied physiology (Bethesda, Md. : 1985) 2004;96(3):938-42.
2004: Woods David; Sanders Julie; Jones Alun; Hawe Emma; Gohlke Peter; Humphries Steve E; Payne John; Montgomery Hugh
The serum angiotensin-converting enzyme and angiotensin II response to altered posture and acute exercise, and the influence of ACE genotype.
European journal of applied physiology 2004;91(2-3):342-8.
2004: Hendriksz C J; Norbury G; Tabrah S; Taylor A; Humphries S E
Homozygous hypercholesterolaemia and ezetimibe: a case report.
Acta paediatrica (Oslo, Norway : 1992) 2004;93(2):280-2.
2004: Syvänne Mikko; Whittall Roslyn A; Turpeinen Ursula; Nieminen Markku S; Frick M Heikki; Kesäniemi Y Antero; Pasternack Amos; Humphries Steve E; Taskinen Marja-Riitta
Serum homocysteine concentrations, gemfibrozil treatment, and progression of coronary atherosclerosis.
Atherosclerosis 2004;172(2):267-72.
2004: Austin Melissa A; Talmud Philippa J; Farin Federico M; Nickerson Deborah A; Edwards Karen L; Leonetti Donna; McNeely Marguerite J; Viernes Hannah-Malia; Humphries Steve E; Fujimoto Wilfred Y
Association of apolipoprotein A5 variants with LDL particle size and triglyceride in Japanese Americans.
Biochimica et biophysica acta 2004;1688(1):1-9.
2004: Talmud Philippa J; Humphries Steve E
Gene: environment interactions and coronary heart disease risk.
World review of nutrition and dietetics 2004;93():29-40.
2003: Robertson Kirsty S; Hawe Emma; Miller George J; Talmud Philippa J; Humphries Steve E;
Human paraoxonase gene cluster polymorphisms as predictors of coronary heart disease risk in the prospective Northwick Park Heart Study II.
Biochimica et biophysica acta 2003;1639(3):203-12.
2003: Juhan-Vague I; Morange P E; Frere C; Aillaud M F; Alessi M C; Hawe E; Boquist S; Tornvall P; Yudkin J S; Tremoli E; Margaglione M; Di Minno G; Hamsten A; Humphries S E;
The plasminogen activator inhibitor-1 -675 4G/5G genotype influences the risk of myocardial infarction associated with elevated plasma proinsulin and insulin concentrations in men from Europe: the HIFMECH study.
Journal of thrombosis and haemostasis : JTH 2003;1(11):2322-9.
2003: Brull D J; Serrano Norma; Zito F; Jones Lisa; Montgomery H E; Rumley A; Sharma Pankaj; Lowe G D O; World M J; Humphries S E; Hingorani A D
Human CRP gene polymorphism influences CRP levels: implications for the prediction and pathogenesis of coronary heart disease.
Arteriosclerosis, thrombosis, and vascular biology 2003;23(11):2063-9.
2003: Jones Alun; Dhamrait Sukhbir S; Payne John R; Hawe Emma; Li Ping; Toor Iqbal S; Luong Le; Wootton Peter T E; Miller George J; Humphries Steve E; Montgomery Hugh E
Genetic variants of angiotensin II receptors and cardiovascular risk in hypertension.
Hypertension 2003;42(4):500-6.
2003: Dhamrait Sukhbir S; Payne John R; Li Ping; Jones Alun; Toor Iqbal S; Cooper Jacqueline A; Hawe Emma; Palmen Jutta M; Wootton Peter T E; Miller George J; Humphries Steve E; Montgomery Hugh E
Variation in bradykinin receptor genes increases the cardiovascular risk associated with hypertension.
European heart journal 2003;24(18):1672-80.
2003: Chapman Caroline M L; Beilby John P; Humphries Steve E; Palmer Lyle J; Thompson Peter L; Hung Joseph
Association of an allelic variant of interleukin-6 with subclinical carotid atherosclerosis in an Australian community population.
European heart journal 2003;24(16):1494-9.
2003: Humphries Steve E
The stromelysin-1 (MMP-3) gene and risk of coronary artery disease: a candidate gene that has won the election?
Thrombosis and haemostasis 2003;90(1):3-6.
2003: Webb Karen E; Martin John F; Cotton James; Erusalimsky Jorge D; Humphries Steve E
The 4830C>A polymorphism within intron 5 affects the pattern of alternative splicing occurring within exon 6 of the thrombopoietin gene.
Experimental hematology 2003;31(6):488-94.
2003: Hubacek Jaroslav A; Pitha Jan; Skodová Zdena; Poledne Rudolf; Lánská Vera; Waterworth Dawn M; Humphries Steve E; Talmud Philippa J;
Polymorphisms in CYP-7A1, not APOE, influence the change in plasma lipids in response to population dietary change in an 8 year follow-up; results from the Czech MONICA study.
Clinical biochemistry 2003;36(4):263-7.
2003: Panahloo Arshia; Mohamed-Ali Vidya; Gray Rosaire P; Humphries Steve E; Yudkin John S
Plasminogen activator inhibitor-1 (PAI-1) activity post myocardial infarction: the role of acute phase reactants, insulin-like molecules and promoter (4G/5G) polymorphism in the PAI-1 gene.
Atherosclerosis 2003;168(2):297-304.
2003: Abuzeid A M; Hawe E; Humphries S E; Talmud Philippa J;
Association between the Ala379Val variant of the lipoprotein associated phospholipase A2 and risk of myocardial infarction in the north and south of Europe.
Atherosclerosis 2003;168(2):283-8.
2003: Humphries Steve E; Hawe Emma; Dhamrait Sukhbir; Miller George J; Talmud Philippa J
In search of genetic precision.
Lancet 2003;361(9372):1908-9; author reply 1909-10.
2003: Elrayess Mohamed A; Webb Karen E; Flavell David M; Syvänne Mikko; Taskinen Marja-Riitta; Frick M Heikki; Nieminen Markku S; Kesäniemi Y Antero; Pasternack Amos; Jukema J Wouter; Kastelein John J P; Zwinderman Aeilko H; Humphries Steve E
A novel functional polymorphism in the PECAM-1 gene (53G>A) is associated with progression of atherosclerosis in the LOCAT and REGRESS studies.
Atherosclerosis 2003;168(1):131-8.
2003: Marks Dalya; Thorogood Margaret; Neil H Andrew W; Humphries Steve E
A review on the diagnosis, natural history, and treatment of familial hypercholesterolaemia.
Atherosclerosis 2003;168(1):1-14.
2003: Wong Wai-man R; Hawe Emma; Li Lai K; Miller George J; Nicaud Viviane; Pennacchio Len A; Humphries Steve E; Talmud Philippa J
Apolipoprotein AIV gene variant S347 is associated with increased risk of coronary heart disease and lower plasma apolipoprotein AIV levels.
Circulation research 2003;92(9):969-75.
2003: Martin Steve; Nicaud Viviane; Humphries Steve E; Talmud Philippa J;
Contribution of APOA5 gene variants to plasma triglyceride determination and to the response to both fat and glucose tolerance challenges.
Biochimica et biophysica acta 2003;1637(3):217-25.
2003: Waterworth D M; Talmud P J; Luan J; Flavell D M; Byrne C D; Humphries S E; Wareham N J
Variants in the APOC3 promoter insulin responsive element modulate insulin secretion and lipids in middle-aged men.
Biochimica et biophysica acta 2003;1637(3):200-6.
2003: Talmud Philippa J; Martin Steve; Steiner George; Flavell David M; Whitehouse David B; Nagl Sylvia; Jackson Richard; Taskinen Marja-Riitta; Frick M Heikki; Nieminen Markku S; Kesäniemi Y Antero; Pasternack Amos; Humphries Steve E; Syvänne Mikko;
Progression of atherosclerosis is associated with variation in the alpha1-antitrypsin gene.
Arteriosclerosis, thrombosis, and vascular biology 2003;23(4):644-9.
2003: Hawe E; Talmud P J; Miller G J; Humphries S E;
Family history is a coronary heart disease risk factor in the Second Northwick Park Heart Study.
Annals of human genetics 2003;67(Pt 2):97-106.
2003: Marks Dalya; Thorogood Margaret; Neil H Andrew W; Wonderling David; Humphries Steve E
Comparing costs and benefits over a 10 year period of strategies for familial hypercholesterolaemia screening.
Journal of public health medicine 2003;25(1):47-52.
2003: Camilleri Raymond S; Mackie Ian J; Humphries Steve E; Machin Samuel J; Cohen Hannah
Lack of association of beta2-glycoprotein I polymorphisms Val247Leu and Trp316Ser with antiphospholipid antibodies in patients with thrombosis and pregnancy complications.
British journal of haematology 2003;120(6):1066-72.
2003: Cotton James M; Hong Ying; Hawe Emma; Mathur Anthony; Humphries Steve E; Brown Angie S; Martin John F; Erusalimsky Jorge D
Rise of circulating thrombopoietin following cardiothoracic surgery is potentiated in patients with coronary atherosclerosis: correlation with a preceding increase in levels of interleukin-6.
Thrombosis and haemostasis 2003;89(3):538-43.
2003: Stephens J W; Humphries S E
The molecular genetics of cardiovascular disease: clinical implications.
Journal of internal medicine 2003;253(2):120-7.
2003: Fisher Rachel M; Benhizia Ferdaous; Schreiber Renate; Makoveichuk Elena; Putt Wendy; Al-Haideri Maysoon; Deckelbaum Richard J; Olivecrona Gunilla; Humphries Steve E; Talmud Philippa J
Enhanced bridging function and augmented monocyte adhesion by lipoprotein lipase N9: insights into increased risk of coronary artery disease in N9 carriers.
Atherosclerosis 2003;166(2):243-51.
2002: Jenny Nancy S; Tracy Russell P; Ogg Malcolm S; Luong Le Ahn; Kuller Lewis H; Arnold Alice M; Sharrett A Richey; Humphries Steve E
In the elderly, interleukin-6 plasma levels and the -174G>C polymorphism are associated with the development of cardiovascular disease.
Arteriosclerosis, thrombosis, and vascular biology 2002;22(12):2066-71.
2002: Gomma A H; Elrayess M A; Knight C J; Hawe E; Fox K M; Humphries S E
The endothelial nitric oxide synthase (Glu298Asp and -786T>C) gene polymorphisms are associated with coronary in-stent restenosis.
European heart journal 2002;23(24):1955-62.
2002: Humphries S E; Martin S; Cooper J; Miller G
Interaction between smoking and the stromelysin-1 (MMP3) gene 5A/6A promoter polymorphism and risk of coronary heart disease in healthy men.
Annals of human genetics 2002;66(Pt 5-6):343-52.
2002: Talmud Philippa J; Hawe Emma; Miller George J; Humphries Steve E
Nonfasting apolipoprotein B and triglyceride levels as a useful predictor of coronary heart disease risk in middle-aged UK men.
Arteriosclerosis, thrombosis, and vascular biology 2002;22(11):1918-23.
2002: Talmud Philippa J; Hawe Emma; Martin Steve; Olivier Michael; Miller George J; Rubin Edward M; Pennacchio Len A; Humphries Steve E
Relative contribution of variation within the APOC3/A4/A5 gene cluster in determining plasma triglycerides.
Human molecular genetics 2002;11(24):3039-46.
2002: Zito Francesco; Lowe Gordon D O; Rumley Ann; McMahon Alex D; Humphries Steve E;
Association of the factor XII 46C>T polymorphism with risk of coronary heart disease (CHD) in the WOSCOPS study.
Atherosclerosis 2002;165(1):153-8.
2002: Papafili Anastasia; Hill Michael R; Brull David J; McAnulty Robin J; Marshall Richard P; Humphries Steve E; Laurent Geoffrey J
Common promoter variant in cyclooxygenase-2 represses gene expression: evidence of role in acute-phase inflammatory response.
Arteriosclerosis, thrombosis, and vascular biology 2002;22(10):1631-6.
2002: Whittall R A; Matheus S; Cranston T; Miller G J; Humphries S E
The intron 14 2140+5G>A variant in the low density lipoprotein receptor gene has no effect on plasma cholesterol levels.
Journal of medical genetics 2002;39(9):e57.
2002: Marshall Richard P; Webb Suzanne; Bellingan Geoffrey J; Montgomery Hugh E; Chaudhari Babar; McAnulty Robin J; Humphries Steve E; Hill Mike R; Laurent Geoffrey J
Angiotensin converting enzyme insertion/deletion polymorphism is associated with susceptibility and outcome in acute respiratory distress syndrome.
American journal of respiratory and critical care medicine 2002;166(5):646-50.
2002: Woods David R; Pollard Andrew J; Collier David J; Jamshidi Yalda; Vassiliou Vassilis; Hawe Emma; Humphries Steve E; Montgomery Hugh E
Insertion/deletion polymorphism of the angiotensin I-converting enzyme gene and arterial oxygen saturation at high altitude.
American journal of respiratory and critical care medicine 2002;166(3):362-6.
2002: Colhoun Helen M; Zito Francesco; Norman Chan N; Rubens Michael B; Fuller John H; Humphries Steve E
Activated factor XII levels and factor XII 46C>T genotype in relation to coronary artery calcification in patients with type 1 diabetes and healthy subjects.
Atherosclerosis 2002;163(2):363-9.
2002: Austin Melissa A; Zimmern Ron L; Humphries Steve E
High "population attributable fraction" for coronary heart disease mortality among relatives in monogenic familial hypercholesterolemia.
Genetics in medicine : official journal of the American College of Medical Genetics 2002;4(4):275-8.
2002: Jamshidi Y; Flavell D M; Hawe E; MacCallum P K; Meade T W; Humphries S E
Genetic determinants of the response to bezafibrate treatment in the lower extremity arterial disease event reduction (LEADER) trial.
Atherosclerosis 2002;163(1):183-92.
2002: Leeson C P M; Hingorani A D; Mullen M J; Jeerooburkhan N; Kattenhorn M; Cole T J; Muller D P R; Lucas A; Humphries S E; Deanfield J E
Glu298Asp endothelial nitric oxide synthase gene polymorphism interacts with environmental and dietary factors to influence endothelial function.
Circulation research 2002;90(11):1153-8.
2002: Marks Dalya; Wonderling David; Thorogood Margaret; Lambert Helen; Humphries Steve E; Neil H Andrew W
Cost effectiveness analysis of different approaches of screening for familial hypercholesterolaemia.
BMJ (Clinical research ed.) 2002;324(7349):1303.
2002: Juhan-Vague I; Morange P E; Aubert H; Henry M; Aillaud M F; Alessi M C; Samnegård A; Hawe E; Yudkin J; Margaglione M; Di Minno G; Hamsten A; Humphries S E;
Plasma thrombin-activatable fibrinolysis inhibitor antigen concentration and genotype in relation to myocardial infarction in the north and south of Europe.
Arteriosclerosis, thrombosis, and vascular biology 2002;22(5):867-73.
2002: Rundek Tanja; Elkind Mitchell S; Pittman John; Boden-Albala Bernadette; Martin Steve; Humphries Steve E; Juo Suh-Hang Hank; Sacco Ralph L
Carotid intima-media thickness is associated with allelic variants of stromelysin-1, interleukin-6, and hepatic lipase genes: the Northern Manhattan Prospective Cohort Study.
Stroke; a journal of cerebral circulation 2002;33(5):1420-3.
2002: Humphries S; Bauters C; Meirhaeghe A; Luong L; Bertrand M; Amouyel P
The 5A6A polymorphism in the promoter of the stromelysin-1 (MMP3) gene as a risk factor for restenosis.
European heart journal 2002;23(9):721-5.
2002: Harding David; Baines Paul B; Brull David; Vassiliou Vassilis; Ellis Ian; Hart Anthony; Thomson Alistair P J; Humphries Steve E; Montgomery Hugh E
Severity of meningococcal disease in children and the angiotensin-converting enzyme insertion/deletion polymorphism.
American journal of respiratory and critical care medicine 2002;165(8):1103-6.
2002: Basso Federica; Lowe Gordon D O; Rumley Ann; McMahon Alex D; Humphries Steve E
Interleukin-6 -174G>C polymorphism and risk of coronary heart disease in West of Scotland coronary prevention study (WOSCOPS).
Arteriosclerosis, thrombosis, and vascular biology 2002;22(4):599-604.
2002: Talmud Philippa J; Humphries Steve E
Gene:environment interaction in lipid metabolism and effect on coronary heart disease risk.
Current opinion in lipidology 2002;13(2):149-54.
2002: Talmud P J; Hawe E; Robertson K; Miller G J; Miller N E; Humphries S E
Genetic and environmental determinants of plasma high density lipoprotein cholesterol and apolipoprotein AI concentrations in healthy middle-aged men.
Annals of human genetics 2002;66(Pt 2):111-24.
2002: Flavell David M; Jamshidi Yalda; Hawe Emma; Pineda Torra Inés; Taskinen Marja-Riitta; Frick M Heikki; Nieminen Markku S; Kesäniemi Y Antero; Pasternack Amos; Staels Bart; Miller George; Humphries Steve E; Talmud Philippa J; Syvänne Mikko
Peroxisome proliferator-activated receptor alpha gene variants influence progression of coronary atherosclerosis and risk of coronary artery disease.
Circulation 2002;105(12):1440-5.
2002: Brull D J; Leeson C P M; Montgomery H E; Mullen M; deDivitiis M; Humphries S E; Deanfield J E;
The effect of the Interleukin-6-174G > C promoter gene polymorphism on endothelial function in healthy volunteers.
European journal of clinical investigation 2002;32(3):153-7.
2002: Marshall Richard P; Webb Suzanne; Hill Mike R; Humphries Steve E; Laurent Geoffrey J
Genetic polymorphisms associated with susceptibility and outcome in ARDS.
Chest 2002;121(3 Suppl):68S-69S.
2002: Brull D J; Sanders J; Rumley A; Lowe G D; Humphries S E; Montgomery H E
Impact of angiotensin converting enzyme inhibition on post-coronary artery bypass interleukin 6 release.
Heart (British Cardiac Society) 2002;87(3):252-5.
2002: Jamshidi Yalda; Montgomery Hugh E; Hense Hans-Werner; Myerson Saul G; Torra Ines Pineda; Staels Bart; World Michael J; Doering Angela; Erdmann Jeanette; Hengstenberg Christian; Humphries Steve E; Schunkert Heribert; Flavell David M
Peroxisome proliferator--activated receptor alpha gene regulates left ventricular growth in response to exercise and hypertension.
Circulation 2002;105(8):950-5.
2002: Woods D R; World M; Rayson M P; Williams A G; Jubb M; Jamshidi Y; Hayward M; Mary D A S G; Humphries S E; Montgomery H E
Endurance enhancement related to the human angiotensin I-converting enzyme I-D polymorphism is not due to differences in the cardiorespiratory response to training.
European journal of applied physiology 2002;86(3):240-4.
2002: Humphries Steve E; Donati Maria Benedetta
Analysis of gene-environment interaction in coronary artery disease.
Italian heart journal : official journal of the Italian Federation of Cardiology 2002;3(1):3-5.
2002: Montgomery Hugh; Brull David; Humphries Steve E
Analysis of gene-environment interactions by "stressing-the-genotype" studies: the angiotensin converting enzyme and exercise-induced left ventricular hypertrophy as an example.
Italian heart journal : official journal of the Italian Federation of Cardiology 2002;3(1):10-4.
2001: Mohamed-Ali V; Flower L; Sethi J; Hotamisligil G; Gray R; Humphries S E; York D A; Pinkney J
beta-Adrenergic regulation of IL-6 release from adipose tissue: in vivo and in vitro studies.
The Journal of clinical endocrinology and metabolism 2001;86(12):5864-9.
2001: Humphries S E; Luong L A; Ogg M S; Hawe E; Miller G J
The interleukin-6 -174 G/C promoter polymorphism is associated with risk of coronary heart disease and systolic blood pressure in healthy men.
European heart journal 2001;22(24):2243-52.
2001: Jeerooburkhan N; Jones L C; Bujac S; Cooper J A; Miller G J; Vallance P; Humphries S E; Hingorani A D
Genetic and environmental determinants of plasma nitrogen oxides and risk of ischemic heart disease.
Hypertension 2001;38(5):1054-61.
2001: Brull D J; Murray L J; Boreham C A; Ralston S H; Montgomery H E; Gallagher A M; McGuigan F E; Davey Smith G; Savage M; Humphries S E; Young I S
Effect of a COL1A1 Sp1 binding site polymorphism on arterial pulse wave velocity: an index of compliance.
Hypertension 2001;38(3):444-8.
2001: Brull D J; Montgomery H E; Sanders J; Dhamrait S; Luong L; Rumley A; Lowe G D; Humphries S E
Interleukin-6 gene -174g>c and -572g>c promoter polymorphisms are strong predictors of plasma interleukin-6 levels after coronary artery bypass surgery.
Arteriosclerosis, thrombosis, and vascular biology 2001;21(9):1458-63.
2001: Talmud P J; Berglund L; Hawe E M; Waterworth D M; Isasi C R; Deckelbaum R E; Starc T; Ginsberg H N; Humphries S E; Shea S
Age-related effects of genetic variation on lipid levels: The Columbia University BioMarkers Study.
Pediatrics 2001;108(3):E50.
2001: Brull D J; Sanders J; Rumley A; Lowe G D; Humphries S E; Montgomery H E
Statin therapy and the acute inflammatory response after coronary artery bypass grafting.
The American journal of cardiology 2001;88(4):431-3.
2001: Talmud P J; Humphries S E
Genetic polymorphisms, lipoproteins and coronary artery disease risk.
Current opinion in lipidology 2001;12(4):405-9.
2001: Humphries S E; Talmud P J; Hawe E; Bolla M; Day I N; Miller G J
Apolipoprotein E4 and coronary heart disease in middle-aged men who smoke: a prospective study.
Lancet 2001;358(9276):115-9.
2001: Woods D; Onambele G; Woledge R; Skelton D; Bruce S; Humphries S E; Montgomery H
Angiotensin-I converting enzyme genotype-dependent benefit from hormone replacement therapy in isometric muscle strength and bone mineral density.
The Journal of clinical endocrinology and metabolism 2001;86(5):2200-4.
2001: Benhizia F; Ginsberg H N; Humphries S E; Talmud P J
Variation in the human ApoB signal peptide modulates ApoB17 translocation.
Biochemical and biophysical research communications 2001;283(1):149-57.
2001: Heath K E; Humphries S E; Middleton-Price H; Boxer M
A molecular genetic service for diagnosing individuals with familial hypercholesterolaemia (FH) in the United Kingdom.
European journal of human genetics : EJHG 2001;9(4):244-52.
2001: Cook D G; Cappuccio F P; Atkinson R W; Wicks P D; Chitolie A; Nakandakare E R; Sagnella G A; Humphries S E
Ethnic differences in fibrinogen levels: the role of environmental factors and the beta-fibrinogen gene.
American journal of epidemiology 2001;153(8):799-806.
2001: Woods D; Hickman M; Jamshidi Y; Brull D; Vassiliou V; Jones A; Humphries S; Montgomery H
Elite swimmers and the D allele of the ACE I/D polymorphism.
Human genetics 2001;108(3):230-2.
2001: Hubacek J A; Waterworth D M; Poledne R; Pitha J; Skodová Z; Humphries S E; Talmud P J
Genetic determination of plasma lipids and insulin in the Czech population.
Clinical biochemistry 2001;34(2):113-8.
2001: Steed L; Kong R; Stygall J; Acharya J; Bolla M; Harrison M J; Humphries S E; Newman S P
The role of apolipoprotein E in cognitive decline after cardiac operation.
The Annals of thoracic surgery 2001;71(3):823-6.
2001: Waterworth D M; Talmud P J; Humphries S E; Wicks P D; Sagnella G A; Strazzullo P; Alberti K G; Cook D G; Cappuccio F P
Variable effects of the APOC3-482C > T variant on insulin, glucose and triglyceride concentrations in different ethnic groups.
Diabetologia 2001;44(2):245-8.
2001: Webb K E; Martin J F; Hamsten A; Eriksson P; Iacoviello L; Gattone M; Donati M B; Di Castelnuovo A; Erusalimsky J; Humphries S E
Polymorphisms in the thrombopoietin gene are associated with risk of myocardial infarction at a young age.
Atherosclerosis 2001;154(3):703-11.
2001: Dekou V; Whincup P; Papacosta O; Ebrahim S; Lennon L; Ueland P M; Refsum H; Humphries S E; Gudnason V
The effect of the C677T and A1298C polymorphisms in the methylenetetrahydrofolate reductase gene on homocysteine levels in elderly men and women from the British regional heart study.
Atherosclerosis 2001;154(3):659-66.
2001: Myerson S G; Montgomery H E; Whittingham M; Jubb M; World M J; Humphries S E; Pennell D J
Left ventricular hypertrophy with exercise and ACE gene insertion/deletion polymorphism: a randomized controlled trial with losartan.
Circulation 2001;103(2):226-30.
2001: Dekou V; Gudnason V; Hawe E; Miller G J; Stansbie D; Humphries S E
Gene-environment and gene-gene interaction in the determination of plasma homocysteine levels in healthy middle-aged men.
Thrombosis and haemostasis 2001;85(1):67-74.
2001: Heath K E; Gahan M; Whittall R A; Humphries S E
Low-density lipoprotein receptor gene (LDLR) world-wide website in familial hypercholesterolaemia: update, new features and mutation analysis.
Atherosclerosis 2001;154(1):243-6.
2001: Hubácek J A; Waterworth D M; Pitha J; Humphries S E; Talmud P J; Poledne R
Polymorphisms in the lipoprotein lipase and hepatic lipase genes and plasma lipid values in the Czech population.
Physiological research / Academia Scientiarum Bohemoslovaca 2001;50(4):345-51.
2001: Humphries S E; Montgomery H E; Talmud P J
Predisposing genes, high-risk environments and coronary artery disease: LPL and fibrinogen as examples.
World review of nutrition and dietetics 2001;89():61-7.
2001: Talmud P J; Waterworth D M; Humphries S E;
Effect of genetic variation on the postprandial response. Results from the European Atherosclerosis Research Study II.
World review of nutrition and dietetics 2001;89():53-60.
2000: Waterworth D M; Talmud P J; Bujac S R; Fisher R M; Miller G J; Humphries S E
Contribution of apolipoprotein C-III gene variants to determination of triglyceride levels and interaction with smoking in middle-aged men.
Arteriosclerosis, thrombosis, and vascular biology 2000;20(12):2663-9.
2000: Woods D R; Humphries S E; Montgomery H E
The ACE I/D polymorphism and human physical performance.
Trends in endocrinology and metabolism: TEM 2000;11(10):416-20.
2000: Liu H; Labeur C; Xu C F; Ferrell R; Lins L; Brasseur R; Rosseneu M; Weiss K M; Humphries S E; Talmud P J
Characterization of the lipid-binding properties and lipoprotein lipase inhibition of a novel apolipoprotein C-III variant Ala23Thr.
Journal of lipid research 2000;41(11):1760-71.
2000: Flower L; Ahuja R H; Humphries S E; Mohamed-Ali V
Effects of sample handling on the stability of interleukin 6, tumour necrosis factor-alpha and leptin.
Cytokine 2000;12(11):1712-6.
2000: Zito F; Drummond F; Bujac S R; Esnouf M P; Morrissey J H; Humphries S E; Miller G J
Epidemiological and genetic associations of activated factor XII concentration with factor VII activity, fibrinopeptide A concentration, and risk of coronary heart disease in men.
Circulation 2000;102(17):2058-62.
2000: Wallace A J; Mann J I; Sutherland W H; Williams S; Chisholm A; Skeaff C M; Gudnason V; Talmud P J; Humphries S E
Variants in the cholesterol ester transfer protein and lipoprotein lipase genes are predictors of plasma cholesterol response to dietary change.
Atherosclerosis 2000;152(2):327-36.
2000: Woods A; Brull D J; Humphries S E; Montgomery H E
Genetics of inflammation and risk of coronary artery disease: the central role of interleukin-6.
European heart journal 2000;21(19):1574-83.
2000: Talmud P J; Palmen J; Miller G; Humphries S E
Effect of microsomal triglyceride transfer protein gene variants (-493G > T, Q95H and H297Q) on plasma lipid levels in healthy middle-aged UK men.
Annals of human genetics 2000;64(Pt 4):269-76.
2000: Waterworth D M; Hubacek J A; Pitha J; Kovar J; Poledne R; Humphries S E; Talmud P J
Plasma levels of remnant particles are determined in part by variation in the APOC3 gene insulin response element and the APOCI-APOE cluster.
Journal of lipid research 2000;41(7):1103-9.
2000: Flavell D M; Pineda Torra I; Jamshidi Y; Evans D; Diamond J R; Elkeles R S; Bujac S R; Miller G; Talmud P J; Staels B; Humphries S E
Variation in the PPARalpha gene is associated with altered function in vitro and plasma lipid concentrations in Type II diabetic subjects.
Diabetologia 2000;43(5):673-80.
2000: Talmud P J; Edwards K L; Turner C M; Newman B; Palmen J M; Humphries S E; Austin M A
Linkage of the cholesteryl ester transfer protein (CETP) gene to LDL particle size: use of a novel tetranucleotide repeat within the CETP promoter.
Circulation 2000;101(21):2461-6.
2000: Heath K E; Day I N; Humphries S E
Universal primer quantitative fluorescent multiplex (UPQFM) PCR: a method to detect major and minor rearrangements of the low density lipoprotein receptor gene.
Journal of medical genetics 2000;37(4):272-80.
2000: Wallace A J; Humphries S E; Fisher R M; Mann J I; Chisholm A; Sutherland W H
Genetic factors associated with response of LDL subfractions to change in the nature of dietary fat.
Atherosclerosis 2000;149(2):387-94.
2000: Hamsten A; Syvänne M; Silveira A; Luong L A; Nieminen M S; Humphries S; Frick M H; Taskinen M R
Fibrinolytic proteins and progression of coronary artery disease in relation to gemfibrozil therapy.
Thrombosis and haemostasis 2000;83(3):397-403.
2000: Talmud P J; Bujac S R; Hall S; Miller G J; Humphries S E
Substitution of asparagine for aspartic acid at residue 9 (D9N) of lipoprotein lipase markedly augments risk of ischaemic heart disease in male smokers.
Atherosclerosis 2000;149(1):75-81.
2000: Williams A G; Rayson M P; Jubb M; World M; Woods D R; Hayward M; Martin J; Humphries S E; Montgomery H E
The ACE gene and muscle performance.
Nature 2000;403(6770):614.
2000: Yudkin J S; Kumari M; Humphries S E; Mohamed-Ali V
Inflammation, obesity, stress and coronary heart disease: is interleukin-6 the link?
Atherosclerosis 2000;148(2):209-14.
2000: Marks D; Wonderling D; Thorogood M; Lambert H; Humphries S E; Neil H A
Screening for hypercholesterolaemia versus case finding for familial hypercholesterolaemia: a systematic review and cost-effectiveness analysis.
Health technology assessment (Winchester, England) 2000;4(29):1-123.
1999: Bolla M K; Wood N; Humphries S E
Rapid determination of apolipoprotein E genotype using a heteroduplex generator.
Journal of lipid research 1999;40(12):2340-5.
1999: Myerson S; Hemingway H; Budget R; Martin J; Humphries S; Montgomery H
Human angiotensin I-converting enzyme gene and endurance performance.
Journal of applied physiology (Bethesda, Md. : 1985) 1999;87(4):1313-6.
1999: Shea S; Isasi C R; Couch S; Starc T J; Tracy R P; Deckelbaum R; Talmud P; Berglund L; Humphries S E
Relations of plasma fibrinogen level in children to measures of obesity, the (G-455-->A) mutation in the beta-fibrinogen promoter gene, and family history of ischemic heart disease: the Columbia University BioMarkers Study.
American journal of epidemiology 1999;150(7):737-46.
1999: Humphries S E; Luong L A; Montgomery H E; Day I N; Mohamed-Ali V; Yudkin J S
Gene-environment interaction in the determination of levels of plasma fibrinogen.
Thrombosis and haemostasis 1999;82(2):818-25.
1999: Dollery C M; Humphries S E; McClelland A; Latchman D S; McEwan J R
In vivo adenoviral gene transfer of TIMP-1 after vascular injury reduces neointimal formation.
Annals of the New York Academy of Sciences 1999;878():742-3.
1999: Dollery C M; Humphries S E; McClelland A; Latchman D S; McEwan J R
Expression of tissue inhibitor of matrix metalloproteinases 1 by use of an adenoviral vector inhibits smooth muscle cell migration and reduces neointimal hyperplasia in the rat model of vascular balloon injury.
Circulation 1999;99(24):3199-205.
1999: Haddad L; Day I N; Hunt S; Williams R R; Humphries S E; Hopkins P N
Evidence for a third genetic locus causing familial hypercholesterolemia. A non-LDLR, non-APOB kindred.
Journal of lipid research 1999;40(6):1113-22.
1999: Waterworth D M; Ribalta J; Nicaud V; Dallongeville J; Humphries S E; Talmud P
ApoCIII gene variants modulate postprandial response to both glucose and fat tolerance tests.
Circulation 1999;99(14):1872-7.
1999: Heath K E; Gudnason V; Humphries S E; Seed M
The type of mutation in the low density lipoprotein receptor gene influences the cholesterol-lowering response of the HMG-CoA reductase inhibitor simvastatin in patients with heterozygous familial hypercholesterolaemia.
Atherosclerosis 1999;143(1):41-54.
1999: Humphries S E; Henry J A; Montgomery H E
Gene-environment interaction in the determination of levels of haemostatic variables involved in thrombosis and fibrinolysis.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 1999;10 Suppl 1():S17-21.
1999: Montgomery H; Clarkson P; Barnard M; Bell J; Brynes A; Dollery C; Hajnal J; Hemingway H; Mercer D; Jarman P; Marshall R; Prasad K; Rayson M; Saeed N; Talmud P; Thomas L; Jubb M; World M; Humphries S
Angiotensin-converting-enzyme gene insertion/deletion polymorphism and response to physical training.
Lancet 1999;353(9152):541-5.
1999: Sanders T A; de Grassi T; Miller G J; Humphries S E
Dietary oleic and palmitic acids and postprandial factor VII in middle-aged men heterozygous and homozygous for factor VII R353Q polymorphism.
The American journal of clinical nutrition 1999;69(2):220-5.
1999: Fisher R M; Burke H; Nicaud V; Ehnholm C; Humphries S E
Effect of variation in the apo A-IV gene on body mass index and fasting and postprandial lipids in the European Atherosclerosis Research Study II. EARS Group.
Journal of lipid research 1999;40(2):287-94.
1998: De Stefano V; Dekou V; Nicaud V; Chasse J F; London J; Stansbie D; Humphries S E; Gudnason V
Linkage disequilibrium at the cystathionine beta synthase (CBS) locus and the association between genetic variation at the CBS locus and plasma levels of homocysteine. The Ears II Group. European Atherosclerosis Research Study.
Annals of human genetics 1998;62(Pt 6):481-90.
1998: Sumeray M S; Montgomery H E; Humphries S E
Beyond coagulation: fibrinogen as a cause of cardiovascular surgical disease.
Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy 1998;12(3):261-5.
1998: Humphries S E; Luong L A; Talmud P J; Frick M H; Kesäniemi Y A; Pasternack A; Taskinen M R; Syvänne M
The 5A/6A polymorphism in the promoter of the stromelysin-1 (MMP-3) gene predicts progression of angiographically determined coronary artery disease in men in the LOCAT gemfibrozil study. Lopid Coronary Angiography Trial.
Atherosclerosis 1998;139(1):49-56.
1998: Wilson D J; Gahan M; Haddad L; Heath K; Whittall R A; Williams R R; Humphries S E; Day I N
A World Wide Web site for low-density lipoprotein receptor gene mutations in familial hypercholesterolemia: sequence-based, tabular, and direct submission data handling.
The American journal of cardiology 1998;81(12):1509-11.
1998: Talmud P J; Hall S; Holleran S; Ramakrishnan R; Ginsberg H N; Humphries S E
LPL promoter -93T/G transition influences fasting and postprandial plasma triglycerides response in African-Americans and Hispanics.
Journal of lipid research 1998;39(6):1189-96.
1998: Curran J M; Evans A; Arveiler D; Luc G; Ruidavets J B; Humphries S E; Green F R
The alpha fibrinogen T/A312 polymorphism in the ECTIM study.
Thrombosis and haemostasis 1998;79(5):1057-8.
1998: Montgomery H E; Marshall R; Hemingway H; Myerson S; Clarkson P; Dollery C; Hayward M; Holliman D E; Jubb M; World M; Thomas E L; Brynes A E; Saeed N; Barnard M; Bell J D; Prasad K; Rayson M; Talmud P J; Humphries S E
Human gene for physical performance.
Nature 1998;393(6682):221-2.
1998: O'Dell S D; Bolla M K; Miller G J; Cooper J A; Humphries S E; Day I N
W64R mutation in beta-3-adrenergic receptor gene and weight in a large population sample.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 1998;22(4):377-9.
1998: Humphries S E; Nicaud V; Margalef J; Tiret L; Talmud P J
Lipoprotein lipase gene variation is associated with a paternal history of premature coronary artery disease and fasting and postprandial plasma triglycerides: the European Atherosclerosis Research Study (EARS).
Arteriosclerosis, thrombosis, and vascular biology 1998;18(4):526-34.
1998: Gudnason V; Stansbie D; Scott J; Bowron A; Nicaud V; Humphries S
C677T (thermolabile alanine/valine) polymorphism in methylenetetrahydrofolate reductase (MTHFR): its frequency and impact on plasma homocysteine concentration in different European populations. EARS group.
Atherosclerosis 1998;136(2):347-54.
1998: Austin M A; Talmud P J; Luong L A; Haddad L; Day I N; Newman B; Edwards K L; Krauss R M; Humphries S E
Candidate-gene studies of the atherogenic lipoprotein phenotype: a sib-pair linkage analysis of DZ women twins.
American journal of human genetics 1998;62(2):406-19.
1998: O'Dell S D; Wilson D J; Durrington P N; Humphries S E; Day I N
CpG-PCR combined with sample pooling and mutant enrichment for CpG mutation screening in population studies.
Clinical chemistry 1998;44(1):183-5.
1997: Humphries S E; Gudnason V; Whittall R; Day I N
Single-strand conformation polymorphism analysis with high throughput modifications, and its use in mutation detection in familial hypercholesterolemia. The IFCC Scientific Division: Committee on Molecular Biology Techniques.
Journal of the International Federation of Clinical Chemistry / IFCC 1997;9(4):156-61.
1997: Heath K E; Luong L A; Leonard J V; Chester A; Shoulders C C; Scott J; Middleton-Price H R; Humphries S E; Talmud P J
The use of a highly informative CA repeat polymorphism within the abetalipoproteinaemia locus (4q22-24).
Prenatal diagnosis 1997;17(12):1181-6.
1997: Fisher R M; Humphries S E; Talmud P J
Common variation in the lipoprotein lipase gene: effects on plasma lipids and risk of atherosclerosis.
Atherosclerosis 1997;135(2):145-59.
1997: Haddad L; Day L B; Attwood J; Povey S; Humphries S E; Day I N
Development of a microsatellite-based approach to co-segregation analysis of familial hypercholesterolaemic kindreds.
Annals of human genetics 1997;61(Pt 6):497-506.
1997: Yudkin J S; Andres C; Mohamed-Ali V; Gould M; Panahloo A; Haines A P; Humphries S; Talmud P
The angiotensin-converting enzyme gene and the angiotensin II type I receptor gene as candidate genes for microalbuminuria. A study in nondiabetic and non-insulin-dependent diabetic subjects.
Arteriosclerosis, thrombosis, and vascular biology 1997;17(10):2188-91.
1997: Hall S; Chu G; Miller G; Cruickshank K; Cooper J A; Humphries S E; Talmud P J
A common mutation in the lipoprotein lipase gene promoter, -93T/G, is associated with lower plasma triglyceride levels and increased promoter activity in vitro.
Arteriosclerosis, thrombosis, and vascular biology 1997;17(10):1969-76.
1997: O'Dell S D; Miller G J; Cooper J A; Hindmarsh P C; Pringle P J; Ford H; Humphries S E; Day I N
Apal polymorphism in insulin-like growth factor II (IGF2) gene and weight in middle-aged males.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 1997;21(9):822-5.
1997: Webb K E; Henney A M; Anglin S; Humphries S E; McEwan J R
Expression of matrix metalloproteinases and their inhibitor TIMP-1 in the rat carotid artery after balloon injury.
Arteriosclerosis, thrombosis, and vascular biology 1997;17(9):1837-44.
1997: Montgomery H E; Clarkson P; Dollery C M; Prasad K; Losi M A; Hemingway H; Statters D; Jubb M; Girvain M; Varnava A; World M; Deanfield J; Talmud P; McEwan J R; McKenna W J; Humphries S
Association of angiotensin-converting enzyme gene I/D polymorphism with change in left ventricular mass in response to physical training.
Circulation 1997;96(3):741-7.
1997: Gerdes C; Fisher R M; Nicaud V; Boer J; Humphries S E; Talmud P J; Faergeman O
Lipoprotein lipase variants D9N and N291S are associated with increased plasma triglyceride and lower high-density lipoprotein cholesterol concentrations: studies in the fasting and postprandial states: the European Atherosclerosis Research Studies.
Circulation 1997;96(3):733-40.
1997: Henry J A; Bolla M; Osmond C; Fall C; Barker D J; Humphries S E
The effects of genotype and infant weight on adult plasma levels of fibrinogen, factor VII, and LDL cholesterol are additive.
Journal of medical genetics 1997;34(7):553-8.
1997: Humphries S E; Panahloo A; Montgomery H E; Green F; Yudkin J
Gene-environment interaction in the determination of levels of haemostatic variables involved in thrombosis and fibrinolysis.
Thrombosis and haemostasis 1997;78(1):457-61.
1997: Talmud P J; Humphries S E
Apolipoprotein C-III gene variation and dyslipidaemia.
Current opinion in lipidology 1997;8(3):154-8.
1997: Humphries S E; Galton D; Nicholls P
Genetic testing for familial hypercholesterolaemia: practical and ethical issues.
QJM : monthly journal of the Association of Physicians 1997;90(3):169-81.
1997: Humphries S E; Gudnason V; Whittall R; Day I N
Single-strand conformation polymorphism analysis with high throughput modifications, and its use in mutation detection in familial hypercholesterolemia. International Federation of Clinical Chemistry Scientific Division: Committee on Molecular Biology Techniques.
Clinical chemistry 1997;43(3):427-35.
1997: Day I N; Haddad L; O'Dell S D; Day L B; Whittall R A; Humphries S E
Identification of a common low density lipoprotein receptor mutation (R329X) in the south of England: complete linkage disequilibrium with an allele of microsatellite D19S394.
Journal of medical genetics 1997;34(2):111-6.
1997: Gudnason V; Thormar K; Humphries S E
Interaction of the cholesteryl ester transfer protein I405V polymorphism with alcohol consumption in smoking and non-smoking healthy men, and the effect on plasma HDL cholesterol and apoAI concentration.
Clinical genetics 1997;51(1):15-21.
1997: Mailly F; Palmen J; Muller D P; Gibbs T; Lloyd J; Brunzell J; Durrington P; Mitropoulos K; Betteridge J; Watts G; Lithell H; Angelico F; Humphries S E; Talmud P J
Familial lipoprotein lipase (LPL) deficiency: a catalogue of LPL gene mutations identified in 20 patients from the UK, Sweden, and Italy.
Human mutation 1997;10(6):465-73.
1997: Day I N; Whittall R A; O'Dell S D; Haddad L; Bolla M K; Gudnason V; Humphries S E
Spectrum of LDL receptor gene mutations in heterozygous familial hypercholesterolemia.
Human mutation 1997;10(2):116-27.
1997: Gudnason V; Sigurdsson G; Nissen H; Humphries S E
Common founder mutation in the LDL receptor gene causing familial hypercholesterolaemia in the Icelandic population.
Human mutation 1997;10(1):36-44.
1996: Thomas A E; Green F R; Humphries S E
Association of genetic variation at the beta-fibrinogen gene locus and plasma fibrinogen levels; interaction between allele frequency of the G/A-455 polymorphism, age and smoking.
Clinical genetics 1996;50(4):184-90.
1996: de Bruin T W; Mailly F; van Barlingen H H; Fisher R; Castro Cabezas M; Talmud P; Dallinga-Thie G M; Humphries S E
Lipoprotein lipase gene mutations D9N and N291S in four pedigrees with familial combined hyperlipidaemia.
European journal of clinical investigation 1996;26(8):631-9.
1996: Talmud P J; Tamplin O J; Heath K; Gaffney D; Day I N; Humphries S E
Rapid testing for three mutations causing familial defective apolipoprotein B100 in 562 patients with familial hypercholesterolaemia.
Atherosclerosis 1996;125(1):135-7.
1996: O'Dell S D; Humphries S E; Day I N
PCR induction of a TaqI restriction site at any CpG dinucleotide using two mismatched primers (CpG-PCR).
Genome research 1996;6(6):558-68.
1996: Gudnason V; Day I N; Humphries S E
Use of the single strand conformation polymorphism method for rapid screening for mutations in the low density lipoprotein receptor gene in patients with familial hypercholesterolemia: effect on plasma lipid levels of different classes of mutations.
Zeitschrift für Gastroenterologie 1996;34 Suppl 3():6-8.
1996: Ye S; Eriksson P; Hamsten A; Kurkinen M; Humphries S E; Henney A M
Progression of coronary atherosclerosis is associated with a common genetic variant of the human stromelysin-1 promoter which results in reduced gene expression.
The Journal of biological chemistry 1996;271(22):13055-60.
1996: Mailly F; Fisher R M; Nicaud V; Luong L A; Evans A E; Marques-Vidal P; Luc G; Arveiler D; Bard J M; Poirier O; Talmud P J; Humphries S E
Association between the LPL-D9N mutation in the lipoprotein lipase gene and plasma lipid traits in myocardial infarction survivors from the ECTIM Study.
Atherosclerosis 1996;122(1):21-8.
1996: Montgomery H E; Clarkson P; Nwose O M; Mikailidis D P; Jagroop I A; Dollery C; Moult J; Benhizia F; Deanfield J; Jubb M; World M; McEwan J R; Winder A; Humphries S
The acute rise in plasma fibrinogen concentration with exercise is influenced by the G-453-A polymorphism of the beta-fibrinogen gene.
Arteriosclerosis, thrombosis, and vascular biology 1996;16(3):386-91.
1995: Gudnason V; Muller D P; Lloyd J K; Humphries S E
Response to drugs and diet in a compound heterozygote for familial hypercholesterolaemia.
Archives of disease in childhood 1995;73(6):538-40.
1995: Panahloo A; Andrès C; Mohamed-Ali V; Gould M M; Talmud P; Humphries S E; Yudkin J S
The insertion allele of the ACE gene I/D polymorphism. A candidate gene for insulin resistance?
Circulation 1995;92(12):3390-3.
1995: Day I N; Humphries S E; Richards S; Norton D; Reid M
High-throughput genotyping using horizontal polyacrylamide gels with wells arranged for microplate array diagonal gel electrophoresis (MADGE).
BioTechniques 1995;19(5):830-5.
1995: Bolla M K; Haddad L; Humphries S E; Winder A F; Day I N
High-throughput method for determination of apolipoprotein E genotypes with use of restriction digestion analysis by microplate array diagonal gel electrophoresis.
Clinical chemistry 1995;41(11):1599-604.
1995: Humphries S E; Peacock R E; Talmud P J
The genetic determinants of plasma cholesterol and response to diet.
Baillière's clinical endocrinology and metabolism 1995;9(4):797-823.
1995: Fisher R M; Mailly F; Peacock R E; Hamsten A; Seed M; Yudkin J S; Beisiegel U; Feussner G; Miller G; Humphries S E
Interaction of the lipoprotein lipase asparagine 291-->serine mutation with body mass index determines elevated plasma triacylglycerol concentrations: a study in hyperlipidemic subjects, myocardial infarction survivors, and healthy adults.
Journal of lipid research 1995;36(10):2104-12.
1995: Ye S; Green F R; Scarabin P Y; Nicaud V; Bara L; Dawson S J; Humphries S E; Evans A; Luc G; Cambou J P
The 4G/5G genetic polymorphism in the promoter of the plasminogen activator inhibitor-1 (PAI-1) gene is associated with differences in plasma PAI-1 activity but not with risk of myocardial infarction in the ECTIM study. Etude CasTemoins de I'nfarctus du Mycocarde.
Thrombosis and haemostasis 1995;74(3):837-41.
1995: Humphries S E; Talmud P J
Hyperlipidaemia associated with genetic variation in the apolipoprotein B gene.
Current opinion in lipidology 1995;6(4):215-22.
1995: Thomas A E; Green F R; Lamlum H; Humphries S E
The association of combined alpha and beta fibrinogen genotype on plasma fibrinogen levels in smokers and non-smokers.
Journal of medical genetics 1995;32(8):585-9.
1995: Day I N; O'Dell S D; Cash I D; Humphries S E; Weavind G P
Electrophoresis for genotyping: temporal thermal gradient gel electrophoresis for profiling of oligonucleotide dissociation.
Nucleic acids research 1995;23(13):2404-12.
1995: Whittall R; Gudnason V; Weavind G P; Day L B; Humphries S E; Day I N
Utilities for high throughput use of the single strand conformational polymorphism method: screening of 791 patients with familial hypercholesterolaemia for mutations in exon 3 of the low density lipoprotein receptor gene.
Journal of medical genetics 1995;32(7):509-15.
1995: Peacock R E; Karpe F; Talmud P J; Hamsten A; Humphries S E
Common variation in the gene for apolipoprotein B modulates postprandial lipoprotein metabolism: a hypothesis generating study.
Atherosclerosis 1995;116(1):135-45.
1995: Montgomery H E; Keeling P J; Goldman J H; Humphries S E; Talmud P J; McKenna W J
Lack of association between the insertion/deletion polymorphism of the angiotensin-converting enzyme gene and idiopathic dilated cardiomyopathy.
Journal of the American College of Cardiology 1995;25(7):1627-31.
1995: Day I N; Whittall R; Gudnason V; Humphries S E
Dried template DNA, dried PCR oligonucleotides and mailing in 96-well plates: LDL receptor gene mutation screening.
BioTechniques 1995;18(6):981-4.
1995: O'Dell S D; Humphries S E; Day I N
Rapid methods for population-scale analysis for gene polymorphisms: the ACE gene as an example.
British heart journal 1995;73(4):368-71.
1995: Ye S; Watts G F; Mandalia S; Humphries S E; Henney A M
Preliminary report: genetic variation in the human stromelysin promoter is associated with progression of coronary atherosclerosis.
British heart journal 1995;73(3):209-15.
1995: Panahloo A; Mohamed-Ali V; Lane A; Green F; Humphries S E; Yudkin J S
Determinants of plasminogen activator inhibitor 1 activity in treated NIDDM and its relation to a polymorphism in the plasminogen activator inhibitor 1 gene.
Diabetes 1995;44(1):37-42.
1995: Humphries S E; Ye S; Talmud P; Bara L; Wilhelmsen L; Tiret L
European Atherosclerosis Research Study: genotype at the fibrinogen locus (G-455-A beta-gene) is associated with differences in plasma fibrinogen levels in young men and women from different regions in Europe. Evidence for gender-genotype-environment interaction.
Arteriosclerosis, thrombosis, and vascular biology 1995;15(1):96-104.
1994: Gudnason V; Day I N; Humphries S E
Effect on plasma lipid levels of different classes of mutations in the low-density lipoprotein receptor gene in patients with familial hypercholesterolemia.
Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association 1994;14(11):1717-22.
1994: Laywood A; Whittall R; Gudnason V; Humphries S E; Day I N
Handling of large (300 x 400 mm), thin (0.4 mm) polyacrylamide gels and recovery as dried gels.
BioTechniques 1994;17(5):850-4.
1994: Peacock R E; Hamsten A; Johansson J; Nilsson-Ehle P; Humphries S E
Associations of genotypes at the apolipoprotein AI-CIII-AIV, apolipoprotein B and lipoprotein lipase gene loci with coronary atherosclerosis and high density lipoprotein subclasses.
Clinical genetics 1994;46(4):273-82.
1994: Humphries S E; Peacock R; Dunning A; Lane A; Green F; Hamsten A
Identification of genetic variation that determines levels of plasma triglycerides and hypercoagulability.
Clinical genetics 1994;46(1 Spec No):19-31.
1994: Humphries S E; Lane A; Green F R; Cooper J; Miller G J
Factor VII coagulant activity and antigen levels in healthy men are determined by interaction between factor VII genotype and plasma triglyceride concentration.
Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association 1994;14(2):193-8.
1994: de Knijff P; Green F; Johansen L G; Grootendorst D; Temple A; Cruickshank J K; Humphries S E; Jespersen J; Kluft C
New alleles in F7 VNTR.
Human molecular genetics 1994;3(2):384.
1994: Seed M; Mailly F; Vallance D; Doherty E; Winder A; Talmud P; Humphries S E
Lipoprotein lipase activity in patients with combined hyperlipidaemia.
The Clinical investigator 1994;72(2):100-6.
1994: Humphries S E
The application of molecular biology techniques to the diagnosis of hyperlipidaemia and other risk factors for cardio-vascular disease.
Annales de biologie clinique 1994;52(1):67-75.
1994: Talmud P J; Ye S; Humphries S E
Polymorphism in the promoter region of the apolipoprotein AI gene associated with differences in apolipoprotein AI levels: the European Atherosclerosis Research Study.
Genetic epidemiology 1994;11(3):265-80.
1993: Humphries S E; Mailly F; Gudnason V; Talmud P
The molecular genetics of pediatric lipid disorders: recent progress and future research directions.
Pediatric research 1993;34(4):403-15.
1993: Gudnason V; King-Underwood L; Seed M; Sun X M; Soutar A K; Humphries S E
Identification of recurrent and novel mutations in exon 4 of the LDL receptor gene in patients with familial hypercholesterolemia in the United Kingdom.
Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association 1993;13(1):56-63.
1992: Humphries S E
The application of molecular biology techniques to the diagnosis of hyperlipidaemia and other risk factors for cardiovascular disease. Committee on Molecular Biology Techniques in Clinical Chemistry of the International Federation of Clinical Chemistry (IFCC).
Journal of the International Federation of Clinical Chemistry / IFCC 1992;4(5):208-18.
1992: Peacock R E; Hamsten A; Nilsson-Ehle P; Humphries S E
Associations between lipoprotein lipase gene polymorphisms and plasma correlations of lipids, lipoproteins and lipase activities in young myocardial infarction survivors and age-matched healthy individuals from Sweden.
Atherosclerosis 1992;97(2-3):171-85.
1992: Humphries S E; Lane A; Dawson S; Green F R
The study of gene-environment interactions that influence thrombosis and fibrinolysis. Genetic variation at the loci for factor VII and plasminogen activator inhibitor-1.
Archives of pathology & laboratory medicine 1992;116(12):1322-9.
1992: Humphries S E; Dunning A; Xu C F; Peacock R; Talmud P; Hamsten A
DNA polymorphism studies. Approaches to elucidating multifactorial ischaemic heart disease: the apo B gene as an example.
Annals of medicine 1992;24(5):349-56.
1992: Humphries S E; Green F R; Temple A; Dawson S; Henney A; Kelleher C H; Wilkes H; Meade T W; Wiman B; Hamsten A
Genetic factors determining thrombosis and fibrinolysis.
Annals of epidemiology 1992;2(4):371-85.
1992: Henney A M; Brotherton D H; Child A H; Humphries S E; Grahame R
Segregation analysis of collagen genes in two families with joint hypermobility syndrome.
British journal of rheumatology 1992;31(3):169-74.
1992: Renges H H; Peacock R; Dunning A M; Talmud P; Humphries S E
Genetic relationship between the 3'-VNTR and diallelic apolipoprotein B gene polymorphisms: haplotype analysis in individuals of European and south Asian origin.
Annals of human genetics 1992;56(Pt 1):11-33.
1992: Mailly F; Moll P; Kottke B A; Kamboh M I; Humphries S E; Ferrell R E
Estimation of the frequency of isoform-genotype discrepancies at the apolipoprotein E locus in heterozygotes for the isoforms.
Genetic epidemiology 1992;9(4):239-48.
1991: Renges H H; Wile D B; McKeigue P M; Marmot M G; Humphries S E
Apolipoprotein B gene polymorphisms are associated with lipid levels in men of South Asian descent.
Atherosclerosis 1991;91(3):267-75.
1991: Houlston R; Lewis B; Humphries S E
Polymorphisms of the apolipoprotein B and E genes and their possible roles in familial and non-familial combined hyperlipidaemia.
Disease markers 1991;9(6):319-25.
1991: Thomas A E; Green F R; Kelleher C H; Wilkes H C; Brennan P J; Meade T W; Humphries S E
Variation in the promoter region of the beta fibrinogen gene is associated with plasma fibrinogen levels in smokers and non-smokers.
Thrombosis and haemostasis 1991;65(5):487-90.
1991: Mailly F; Xu C F; Xhignesse M; Lussier-Cacan S; Talmud P J; Davignon J; Humphries S E; Nestruck A C
Characterization of a new apolipoprotein E5 variant detected in two French-Canadian subjects.
Journal of lipid research 1991;32(4):613-20.

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