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Mien-Chie Hung

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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TOP 3
Wang Shao-Chun; Hung Mien-Chie
Nuclear translocation of the epidermal growth factor receptor family membrane tyrosine kinase receptors.
Zhang Dongwei; LaFortune Tiffany A; Krishnamurthy Savitri; Esteva Francisco J; Cristofanilli Massimo; Liu Ping; Lucci Anthony; Singh Balraj; Hung Mien-Chie; Hortobagyi Gabriel N; Ueno Naoto T
Epidermal growth factor receptor tyrosine kinase inhibitor reverses mesenchymal to epithelial phenotype and inhibits metastasis in inflammatory breast cancer.
Kuo Hsu-Ping; Lee Dung-Fang; Xia Weiya; Wei Yongkun; Hung Mien-Chie
TNFalpha induces HIF-1alpha expression through activation of IKKbeta.

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All Publications

2009: Wang Shao-Chun; Hung Mien-Chie
Nuclear translocation of the epidermal growth factor receptor family membrane tyrosine kinase receptors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(21):6484-9.
2009: Zhang Dongwei; LaFortune Tiffany A; Krishnamurthy Savitri; Esteva Francisco J; Cristofanilli Massimo; Liu Ping; Lucci Anthony; Singh Balraj; Hung Mien-Chie; Hortobagyi Gabriel N; Ueno Naoto T
Epidermal growth factor receptor tyrosine kinase inhibitor reverses mesenchymal to epithelial phenotype and inhibits metastasis in inflammatory breast cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(21):6639-48.
2009: Kuo Hsu-Ping; Lee Dung-Fang; Xia Weiya; Wei Yongkun; Hung Mien-Chie
TNFalpha induces HIF-1alpha expression through activation of IKKbeta.
Biochemical and biophysical research communications 2009;389(4):640-4.
2009: Kuo Hsu-Ping; Lee Dung-Fang; Xia Weiya; Lai Chien-Chen; Li Long-Yuan; Hung Mien-Chie
Phosphorylation of ARD1 by IKKbeta contributes to its destabilization and degradation.
Biochemical and biophysical research communications 2009;389(1):156-61.
2009: Chou Chao-Kai; Lee Dung-Fang; Sun Hui-Lung; Li Long-Yuan; Lin Chun-Yi; Huang Wei-Chien; Hsu Jung-Mao; Kuo Hsu-Ping; Yamaguchi Hirohito; Wang Ying-Nai; Liu Mo; Wu Hsin-Yi; Liao Pao-Chi; Yen Chia-Jui; Hung Mien-Chie
The suppression of MAD1 by AKT-mediated phosphorylation activates MAD1 target genes transcription.
Molecular carcinogenesis 2009;48(11):1048-58.
2009: Lee Dung-Fang; Kuo Hsu-Ping; Liu Mo; Chou Chao-Kai; Xia Weiya; Du Yi; Shen Jia; Chen Chun-Te; Huo Longfei; Hsu Ming-Chuan; Li Chia-Wei; Ding Qingqing; Liao Tsai-Lien; Lai Chien-Chen; Lin Ann-Chi; Chang Ya-Hui; Tsai Shih-Feng; Li Long-Yuan; Hung Mien-Chie
KEAP1 E3 ligase-mediated downregulation of NF-kappaB signaling by targeting IKKbeta.
Molecular cell 2009;36(1):131-40.
2009: Melnikova Vladislava O; Balasubramanian Krishnakumar; Villares Gabriel J; Dobroff Andrey S; Zigler Maya; Wang Hua; Petersson Frederik; Price Janet E; Schroit Alan; Prieto Victor G; Hung Mien-Chie; Bar-Eli Menashe
Crosstalk between protease-activated receptor 1 and platelet-activating factor receptor regulates melanoma cell adhesion molecule (MCAM/MUC18) expression and melanoma metastasis.
The Journal of biological chemistry 2009;284(42):28845-55.
2009: Lu Jing; Guo Hua; Treekitkarnmongkol Warapen; Li Ping; Zhang Jian; Shi Bin; Ling Chen; Zhou Xiaoyan; Chen Tongzhen; Chiao Paul J; Feng Xinhua; Seewaldt Victoria L; Muller William J; Sahin Aysegul; Hung Mien-Chie; Yu Dihua
14-3-3zeta Cooperates with ErbB2 to promote ductal carcinoma in situ progression to invasive breast cancer by inducing epithelial-mesenchymal transition.
Cancer cell 2009;16(3):195-207.
2009: Jiralerspong Sao; Angulo Ana M Gonzalez; Hung Mien-Chie
Expanding the arsenal: metformin for the treatment of triple-negative breast cancer?
Cell cycle (Georgetown, Tex.) 2009;8(17):2681.
2009: Sher Y-P; Tzeng T-F; Kan S-F; Hsu J; Xie X; Han Z; Lin W-C; Li L-Y; Hung M-C
Cancer targeted gene therapy of BikDD inhibits orthotopic lung cancer growth and improves long-term survival.
Oncogene 2009;28(37):3286-95.
2009: Xie Xiaoming; Hsu Jennifer L; Choi Min-Gew; Xia Weiya; Yamaguchi Hirohito; Chen Chun-Te; Trinh Bon Q; Lu Zhen; Ueno Naoto T; Wolf Judith K; Bast Robert C; Hung Mien-Chie
A novel hTERT promoter-driven E1A therapeutic for ovarian cancer.
Molecular cancer therapeutics 2009;8(8):2375-82.
2009: Sun Hui-Lung; Tsai An-Chi; Pan Shiow-Lin; Ding Qingqing; Yamaguchi Hirohito; Lin Chun-Nan; Hung Mien-Chie; Teng Che-Ming
EPOX inhibits angiogenesis by degradation of Mcl-1 through ERK inactivation.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(15):4904-14.
2009: Jiralerspong Sao; Palla Shana L; Giordano Sharon H; Meric-Bernstam Funda; Liedtke Cornelia; Barnett Chad M; Hsu Limin; Hung Mien-Chie; Hortobagyi Gabriel N; Gonzalez-Angulo Ana M
Metformin and pathologic complete responses to neoadjuvant chemotherapy in diabetic patients with breast cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2009;27(20):3297-302.
2009: Liao Y; Wei Y; Zhou X; Yang J-Y; Dai C; Chen Y-J; Agarwal N K; Sarbassov D; Shi D; Yu D; Hung M-C
Peptidyl-prolyl cis/trans isomerase Pin1 is critical for the regulation of PKB/Akt stability and activation phosphorylation.
Oncogene 2009;28(26):2436-45.
2009: Xia Weiya; Wei Yongkun; Du Yi; Liu Jinsong; Chang Bin; Yu Yung-Luen; Huo Long-Fei; Miller Stephanie; Hung Mien-Chie
Nuclear expression of epidermal growth factor receptor is a novel prognostic value in patients with ovarian cancer.
Molecular carcinogenesis 2009;48(7):610-7.
2009: Liu Shuying; Umezu-Goto Makiko; Murph Mandi; Lu Yiling; Liu Wenbin; Zhang Fan; Yu Shuangxing; Stephens L Clifton; Cui Xiaojiang; Murrow George; Coombes Kevin; Muller William; Hung Mien-Chie; Perou Charles M; Lee Adrian V; Fang Xianjun; Mills Gordon B
Expression of autotaxin and lysophosphatidic acid receptors increases mammary tumorigenesis, invasion, and metastases.
Cancer cell 2009;15(6):539-50.
2009: Cheng Xiaoyun; Hung Mien-Chie
Regulation of breast cancer metastasis by atypical chemokine receptors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(9):2951-3.
2009: Hawthorne Valerie S; Huang Wen-Chien; Neal Christopher L; Tseng Ling-Min; Hung Mien-Chie; Yu Dihua
ErbB2-mediated Src and signal transducer and activator of transcription 3 activation leads to transcriptional up-regulation of p21Cip1 and chemoresistance in breast cancer cells.
Molecular cancer research : MCR 2009;7(4):592-600.
2009: Neal Christopher L; Yao Jun; Yang Wentao; Zhou Xiaoyan; Nguyen Nina T; Lu Jing; Danes Christopher G; Guo Hua; Lan Keng-Hsueh; Ensor Joe; Hittelman Walter; Hung Mien-Chie; Yu Dihua
14-3-3zeta overexpression defines high risk for breast cancer recurrence and promotes cancer cell survival.
Cancer research 2009;69(8):3425-32.
2009: Yamaguchi Hirohito; Woods Nicholas T; Piluso Landon G; Lee Heng-Huan; Chen Jiandong; Bhalla Kapil N; Monteiro Alvaro; Liu Xuan; Hung Mien-Chie; Wang Hong-Gang
p53 acetylation is crucial for its transcription-independent proapoptotic functions.
The Journal of biological chemistry 2009;284(17):11171-83.
2009: Huang Wei-Chien; Hung Mien-Chie
Induction of Akt activity by chemotherapy confers acquired resistance.
Journal of the Formosan Medical Association = Taiwan yi zhi 2009;108(3):180-94.
2009: Hung Mien-Chie; Mills Gordon B; Yu Dihua
Oxygen sensor boosts growth factor signaling.
Nature medicine 2009;15(3):246-7.
2009: Song Shumei; Mazurek Nachman; Liu Chunming; Sun Yunjie; Ding Qing Qing; Liu Kaifeng; Hung Mien-Chie; Bresalier Robert S
Galectin-3 mediates nuclear beta-catenin accumulation and Wnt signaling in human colon cancer cells by regulation of glycogen synthase kinase-3beta activity.
Cancer research 2009;69(4):1343-9.
2009: Yang Jer-Yen; Hung Mien-Chie
A new fork for clinical application: targeting forkhead transcription factors in cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(3):752-7.
2009: Hildebrandt Michelle A T; Yang Hushan; Hung Mien-Chie; Izzo Julie G; Huang Maosheng; Lin Jie; Ajani Jaffer A; Wu Xifeng
Genetic variations in the PI3K/PTEN/AKT/mTOR pathway are associated with clinical outcomes in esophageal cancer patients treated with chemoradiotherapy.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2009;27(6):857-71.
2009: Izzo J G; Wu X; Wu T-T; Huang P; Lee J-S; Liao Z; Lee J H; Bhutani M S; Hofstetter W; Maru D; Hung M-C; Ajani J A
Therapy-induced expression of NF-kappaB portends poor prognosis in patients with localized esophageal cancer undergoing preoperative chemoradiation.
Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus / I.S.D.E 2009;22(2):127-32.
2008: Lee Cathy; Dhillon Jaspreet; Wang Michelle Y C; Gao Yuanyuan; Hu Kaiji; Park Eugene; Astanehe Arezoo; Hung Mien-Chie; Eirew Peter; Eaves Connie J; Dunn Sandra E
Targeting YB-1 in HER-2 overexpressing breast cancer cells induces apoptosis via the mTOR/STAT3 pathway and suppresses tumor growth in mice.
Cancer research 2008;68(21):8661-6.
2008: Lee Dung-Fang; Kuo Hsu-Ping; Chen Chun-Te; Wei Yongkun; Chou Chao-Kai; Hung Jen-Yu; Yen Chia-Jui; Hung Mien-Chie
IKKbeta suppression of TSC1 function links the mTOR pathway with insulin resistance.
International journal of molecular medicine 2008;22(5):633-8.
2008: Wang Rui-Hong; Zheng Yin; Kim Hyun-Seok; Xu Xiaoling; Cao Liu; Luhasen Tyler; Lee Mi-Hye; Xiao Cuiying; Vassilopoulos Athanassios; Chen Weiping; Gardner Kevin; Man Yan-Gao; Hung Mien-Chie; Finkel Toren; Deng Chu-Xia
Interplay among BRCA1, SIRT1, and Survivin during BRCA1-associated tumorigenesis.
Molecular cell 2008;32(1):11-20.
2008: Yamaguchi Hirohito; Ding Yi; Lee Jin-Fong; Zhang Ming; Pal Ashutosh; Bornmann William; Yan Duen-Hwa; Hung Mien-Chie
Interferon-inducible protein IFIXalpha inhibits cell invasion by upregulating the metastasis suppressor maspin.
Molecular carcinogenesis 2008;47(10):739-43.
2008: Lee Dung-Fang; Hung Mien-Chie
Advances in targeting IKK and IKK-related kinases for cancer therapy.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(18):5656-62.
2008: Wei Yongkun; Xia Weiya; Zhang Zhihong; Liu Jinsong; Wang Huamin; Adsay Nazmi V; Albarracin Constance; Yu Dihua; Abbruzzese James L; Mills Gordon B; Bast Robert C; Hortobagyi Gabriel N; Hung Mien-Chie
Loss of trimethylation at lysine 27 of histone H3 is a predictor of poor outcome in breast, ovarian, and pancreatic cancers.
Molecular carcinogenesis 2008;47(9):701-6.
2008: Ding Qingqing; Huo Longfei; Yang Jer-Yen; Xia Weiya; Wei Yongkun; Liao Yong; Chang Chun-Ju; Yang Yan; Lai Chien-Chen; Lee Dung-Fang; Yen Chia-Jui; Chen Yun-Ju Rita; Hsu Jung-Mao; Kuo Hsu-Ping; Lin Chun-Yi; Tsai Fuu-Jen; Li Long-Yuan; Tsai Chang-Hai; Hung Mien-Chie
Down-regulation of myeloid cell leukemia-1 through inhibiting Erk/Pin 1 pathway by sorafenib facilitates chemosensitization in breast cancer.
Cancer research 2008;68(15):6109-17.
2008: Stemke-Hale Katherine; Gonzalez-Angulo Ana Maria; Lluch Ana; Neve Richard M; Kuo Wen-Lin; Davies Michael; Carey Mark; Hu Zhi; Guan Yinghui; Sahin Aysegul; Symmans W Fraser; Pusztai Lajos; Nolden Laura K; Horlings Hugo; Berns Katrien; Hung Mien-Chie; van de Vijver Marc J; Valero Vicente; Gray Joe W; Bernards René; Mills Gordon B; Hennessy Bryan T
An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer.
Cancer research 2008;68(15):6084-91.
2008: Su Jen-Liang; Chen Pai-Sheng; Chien Ming-Hsien; Chen Poshen B; Chen Ya-Huey; Lai Chien-Chen; Hung Mien-Chie; Kuo Min-Liang
Further evidence for expression and function of the VEGF-C/VEGFR-3 axis in cancer cells.
Cancer cell 2008;13(6):557-60.
2008: Weihua Zhang; Tsan Rachel; Huang Wei-Chien; Wu Qiuyu; Chiu Chao-Hua; Fidler Isaiah J; Hung Mien-Chie
Survival of cancer cells is maintained by EGFR independent of its kinase activity.
Cancer cell 2008;13(5):385-93.
2008: Yen Chia-Jui; Izzo Julie G; Lee Dung-Fang; Guha Sushovan; Wei Yongkun; Wu Tsung-Teh; Chen Chun-Te; Kuo Hsu-Ping; Hsu Jung-Mao; Sun Hui-Lung; Chou Chao-Kai; Buttar Navtej S; Wang Kenneth K; Huang Peng; Ajani Jaffer; Hung Mien-Chie
Bile acid exposure up-regulates tuberous sclerosis complex 1/mammalian target of rapamycin pathway in Barrett's-associated esophageal adenocarcinoma.
Cancer research 2008;68(8):2632-40.
2008: Yang Jer-Yen; Zong Cong S; Xia Weiya; Yamaguchi Hirohito; Ding Qingqing; Xie Xiaoming; Lang Jing-Yu; Lai Chien-Chen; Chang Chun-Ju; Huang Wei-Chien; Huang Hsin; Kuo Hsu-Ping; Lee Dung-Fang; Li Long-Yuan; Lien Huang-Chun; Cheng Xiaoyun; Chang King-Jen; Hsiao Chwan-Deng; Tsai Fuu-Jen; Tsai Chang-Hai; Sahin Aysegul A; Muller William J; Mills Gordon B; Yu Dihua; Hortobagyi Gabriel N; Hung Mien-Chie
ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation.
Nature cell biology 2008;10(2):138-48.
2008: Kang Tiebang; Wei Yongkun; Honaker Yuchi; Yamaguchi Hiroshi; Appella Ettore; Hung Mien-Chie; Piwnica-Worms Helen
GSK-3 beta targets Cdc25A for ubiquitin-mediated proteolysis, and GSK-3 beta inactivation correlates with Cdc25A overproduction in human cancers.
Cancer cell 2008;13(1):36-47.
2007: Lee Dung-Fang; Hung Mien-Chie
All roads lead to mTOR: integrating inflammation and tumor angiogenesis.
Cell cycle (Georgetown, Tex.) 2007;6(24):3011-4.
2007: Cheng Xiaoyun; Hung Mien-Chie
Breast cancer brain metastases.
Cancer metastasis reviews 2007;26(3-4):635-43.
2007: Lien H C; Hsiao Y H; Lin Y S; Yao Y T; Juan H F; Kuo W H; Hung Mien-Chie; Chang K J; Hsieh F J
Molecular signatures of metaplastic carcinoma of the breast by large-scale transcriptional profiling: identification of genes potentially related to epithelial-mesenchymal transition.
Oncogene 2007;26(57):7859-71.
2007: Lo Hui-Wen; Hsu Sheng-Chieh; Xia Weiya; Cao Xinyu; Shih Jin-Yuan; Wei Yongkun; Abbruzzese James L; Hortobagyi Gabriel N; Hung Mien-Chie
Epidermal growth factor receptor cooperates with signal transducer and activator of transcription 3 to induce epithelial-mesenchymal transition in cancer cells via up-regulation of TWIST gene expression.
Cancer research 2007;67(19):9066-76.
2007: Akcakanat Argun; Singh Gopal; Hung Mien-Chie; Meric-Bernstam Funda
Rapamycin regulates the phosphorylation of rictor.
Biochemical and biophysical research communications 2007;362(2):330-3.
2007: Nakagawa-Goto Kyoko; Yamada Koji; Nakamura Seikou; Chen Tzu-Hsuan; Chiang Po-Cheng; Bastow Kenneth F; Wang Shao-Chun; Spohn Bill; Hung Mien-Chie; Lee Fang-Yu; Lee Fang-Chen; Lee Kuo-Hsiung
Antitumor agents. 258. Syntheses and evaluation of dietary antioxidant--taxoid conjugates as novel cytotoxic agents.
Bioorganic & medicinal chemistry letters 2007;17(18):5204-9.
2007: Lee Dung-Fang; Kuo Hsu-Ping; Chen Chun-Te; Hsu Jung-Mao; Chou Chao-Kai; Wei Yongkun; Sun Hui-Lung; Li Long-Yuan; Ping Bo; Huang Wei-Chien; He Xianghuo; Hung Jen-Yu; Lai Chien-Chen; Ding Qingqing; Su Jen-Liang; Yang Jer-Yen; Sahin Aysegul A; Hortobagyi Gabriel N; Tsai Fuu-Jen; Tsai Chang-Hai; Hung Mien-Chie
IKK beta suppression of TSC1 links inflammation and tumor angiogenesis via the mTOR pathway.
Cell 2007;130(3):440-55.
2007: Brugge Joan; Hung Mien-Chie; Mills Gordon B
A new mutational AKTivation in the PI3K pathway.
Cancer cell 2007;12(2):104-7.
2007: Wang Xianhui; Zheng Mingzhe; Liu Gang; Xia Weiya; McKeown-Longo Paula J; Hung Mien-Chie; Zhao Jihe
Krüppel-like factor 8 induces epithelial to mesenchymal transition and epithelial cell invasion.
Cancer research 2007;67(15):7184-93.
2007: Izzo Julie G; Luthra Rajyalakshmi; Sims-Mourtada Jennifer; Chao K S Clifford; Lee Jeffrey H; Wu Tsung-The; Correa Arlene M; Luthra Madan; Aggarwal Bharat; Hung Mien-Chie; Ajani Jaffer A
Emerging molecular targets in esophageal cancers.
Gastrointestinal cancer research : GCR 2007;1(4 Suppl 2):S3-6.
2007: Xie Xiaoming; Xia Weiya; Li Zhongkui; Kuo Hsu-Ping; Liu Yuanfang; Li Zheng; Ding Qingqing; Zhang Su; Spohn Bill; Yang Yan; Wei Yongkun; Lang Jing-Yu; Evans Douglas B; Chiao Paul J; Abbruzzese James L; Hung Mien-Chie
Targeted expression of BikDD eradicates pancreatic tumors in noninvasive imaging models.
Cancer cell 2007;12(1):52-65.
2007: Izzo Julie G; Malhotra Usha; Wu Tsung-Teh; Luthra Rajalakshmi; Correa Arlene M; Swisher Stephen G; Hofstetter Wayne; Chao K S Clifford; Hung Mien-Chie; Ajani Jaffer A
Clinical biology of esophageal adenocarcinoma after surgery is influenced by nuclear factor-kappaB expression.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2007;16(6):1200-5.
2007: Ding Qingqing; He Xianghuo; Hsu Jung-Mao; Xia Weiya; Chen Chun-Te; Li Long-Yuan; Lee Dung-Fang; Liu Jaw-Ching; Zhong Qing; Wang Xiaodong; Hung Mien-Chie
Degradation of Mcl-1 by beta-TrCP mediates glycogen synthase kinase 3-induced tumor suppression and chemosensitization.
Molecular and cellular biology 2007;27(11):4006-17.
2007: Ding Qingqing; He Xianghuo; Xia Weiya; Hsu Jung-Mao; Chen Chun-Te; Li Long-Yuan; Lee Dung-Fang; Yang Jer-Yen; Xie Xiaoming; Liu Jaw-Ching; Hung Mien-Chie
Myeloid cell leukemia-1 inversely correlates with glycogen synthase kinase-3beta activity and associates with poor prognosis in human breast cancer.
Cancer research 2007;67(10):4564-71.
2007: Casimiro Mathew; Rodriguez Olga; Pootrakul Llana; Aventian Maral; Lushina Nadia; Cromelin Caroline; Ferzli Georgina; Johnson Kevin; Fricke Stanley; Diba Fantahun; Kallakury Bhaskar; Ohanyerenwa Chioma; Chen Maxine; Ostrowski Michael; Hung Mien-Chie; Rabbani Shafaat A; Datar Ram; Cote Richard; Pestell Richard; Albanese Chris
ErbB-2 induces the cyclin D1 gene in prostate epithelial cells in vitro and in vivo.
Cancer research 2007;67(9):4364-72.
2007: Uwagawa Tadashi; Li Zhongkui; Chang Zhe; Xia Qianghua; Peng Bailu; Sclabas Guido M; Ishiyama Satoshi; Hung Mien-Chie; Evans Douglas B; Abbruzzese James L; Chiao Paul J
Mechanisms of synthetic serine protease inhibitor (FUT-175)-mediated cell death.
Cancer 2007;109(10):2142-53.
2007: Izzo Julie G; Luthra Rajyalakshmi; Wu Tseung-Teh; Correa Arlene M; Luthra Madan; Anandasabapathy Sharmila; Chao K S Clifford; Hung Mien-Chie; Aggarwal Bharat; Hittelman Walter N; Ajani Jaffer A
Molecular mechanisms in Barrett's metaplasia and its progression.
Seminars in oncology 2007;34(2 Suppl 1):S2-6.
2007: Huang Wei-Chien; Ju Tsai-Kai; Hung Mien-Chie; Chen Ching-Chow
Phosphorylation of CBP by IKKalpha promotes cell growth by switching the binding preference of CBP from p53 to NF-kappaB.
Molecular cell 2007;26(1):75-87.
2007: Hsu Sheng-Chieh; Hung Mien-Chie
Characterization of a novel tripartite nuclear localization sequence in the EGFR family.
The Journal of biological chemistry 2007;282(14):10432-40.
2007: Su J-L; Yen C-J; Chen P-S; Chuang S-E; Hong C-C; Kuo I-H; Chen H-Y; Hung M-C; Kuo M-L
The role of the VEGF-C/VEGFR-3 axis in cancer progression.
British journal of cancer 2007;96(4):541-5.
2007: Liao Yong; Yu Dihua; Hung Mien-Chie
Novel approaches for chemosensitization of breast cancer cells: the E1A story.
Advances in experimental medicine and biology 2007;608():144-69.
2007: Tsai Kuang-Lei; Sun Yuh-Ju; Huang Cheng-Yang; Yang Jer-Yen; Hung Mien-Chie; Hsiao Chwan-Deng
Crystal structure of the human FOXO3a-DBD/DNA complex suggests the effects of post-translational modification.
Nucleic acids research 2007;35(20):6984-94.
2007: Lo H-W; Hung M-C
Nuclear EGFR signalling network in cancers: linking EGFR pathway to cell cycle progression, nitric oxide pathway and patient survival.
British journal of cancer 2007;96 Suppl():R16-20.
2006: Wang Shao-Chun; Nakajima Yusuke; Yu Yung-Luen; Xia Weiya; Chen Chun-Te; Yang Cheng-Chieh; McIntush Eric W; Li Long-Yuan; Hawke David H; Kobayashi Ryuji; Hung Mien-Chie
Tyrosine phosphorylation controls PCNA function through protein stability.
Nature cell biology 2006;8(12):1359-68.
2006: Jiang Hong; Olson Melissa V; Medrano Diana R; Lee Ok-Hee; Xu Jing; Piao Yuji; Alonso Marta M; Gomez-Manzano Candelaria; Hung Mien-Chie; Yung W K Alfred; Fueyo Juan
A novel CRM1-dependent nuclear export signal in adenoviral E1A protein regulated by phosphorylation.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(14):2603-5.
2006: Meric-Bernstam Funda; Hung Mien-Chie
Advances in targeting human epidermal growth factor receptor-2 signaling for cancer therapy.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(21):6326-30.
2006: Ping Bo; He Xianghuo; Xia Weiya; Lee Dung-Fang; Wei Yongkun; Yu Dihua; Mills Gordon; Shi Daren; Hung Mien-Chie
Cytoplasmic expression of p21CIP1/WAF1 is correlated with IKKbeta overexpression in human breast cancers.
International journal of oncology 2006;29(5):1103-10.
2006: Yang Jer-Yen; Zong Cong S; Xia Weiya; Wei Yongkun; Ali-Seyed Mohamed; Li Zheng; Broglio Kristine; Berry Donald A; Hung Mien-Chie
MDM2 promotes cell motility and invasiveness by regulating E-cadherin degradation.
Molecular and cellular biology 2006;26(19):7269-82.
2006: Yu Zhenming; Xia Weiya; Wang Hong-Ying; Wang Shao-Chun; Pan Yong; Kwong Ka Yin; Hortobagyi Gabriel N; Hung Mien-Chie
Antitumor activity of an Ets protein, PEA3, in breast cancer cell lines MDA-MB-361DYT2 and BT474M1.
Molecular carcinogenesis 2006;45(9):667-75.
2006: Xia Wei-Ya; Lien Huang-Chun; Wang Shao-Chun; Pan Yung; Sahin Aysegul; Kuo Yau-Hung; Chang King-Jeng; Zhou Xin; Wang Hongying; Yu Zhengming; Hortobagyi Gabriel; Shi Dar-Ren; Hung Mien-Chie
Expression of PEA3 and lack of correlation between PEA3 and HER-2/neu expression in breast cancer.
Breast cancer research and treatment 2006;98(3):295-301.
2006: Lo Hui-Wen; Ali-Seyed Mohamed; Wu Yadi; Bartholomeusz Geoffrey; Hsu Sheng-Chieh; Hung Mien-Chie
Nuclear-cytoplasmic transport of EGFR involves receptor endocytosis, importin beta1 and CRM1.
Journal of cellular biochemistry 2006;98(6):1570-83.
2006: Chou C-K; Hung J-Y; Liu J-C; Chen C-T; Hung M-C
An attenuated Salmonella oral DNA vaccine prevents the growth of hepatocellular carcinoma and colon cancer that express alpha-fetoprotein.
Cancer gene therapy 2006;13(8):746-52.
2006: Day C-P; Rau K-M; Qiu L; Liu C-W; Kuo H-P; Xie X; Lopez-Berestein G; Hortobagyi G N; Hung M-C
Mutant Bik expression mediated by the enhanced minimal topoisomerase IIalpha promoter selectively suppressed breast tumors in an animal model.
Cancer gene therapy 2006;13(7):706-19.
2006: Nahta Rita; Yu Dihua; Hung Mien-Chie; Hortobagyi Gabriel N; Esteva Francisco J
Mechanisms of disease: understanding resistance to HER2-targeted therapy in human breast cancer.
Nature clinical practice. Oncology 2006;3(5):269-80.
2006: Li Zheng; Ding Qingqing; Li Yan; Miller Stephanie A; Abbruzzese James L; Hung Mien-Chie
Suppression of pancreatic tumor progression by systemic delivery of a pancreatic-cancer-specific promoter driven Bik mutant.
Cancer letters 2006;236(1):58-63.
2006: Su Jen-Liang; Yang Pan-Chyr; Shih Jin-Yuan; Yang Ching-Yao; Wei Lin-Hung; Hsieh Chang-Yao; Chou Chia-Hung; Jeng Yung-Ming; Wang Ming-Yang; Chang King-Jen; Hung Mien-Chie; Kuo Min-Liang
The VEGF-C/Flt-4 axis promotes invasion and metastasis of cancer cells.
Cancer cell 2006;9(3):209-23.
2006: Konopleva Marina; Zhang Weiguo; Shi Yue-Xi; McQueen Teresa; Tsao Twee; Abdelrahim Maen; Munsell Mark F; Johansen Mary; Yu Dihua; Madden Timothy; Safe Stephen H; Hung Mien-Chie; Andreeff Michael
Synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid induces growth arrest in HER2-overexpressing breast cancer cells.
Molecular cancer therapeutics 2006;5(2):317-28.
2006: Bartholomeusz Geoffrey; Wu Yadi; Ali Seyed Mohamad; Xia Weiya; Kwong Ka-Yin; Hortobagyi Gabriel; Hung Mien-Chie
Nuclear translocation of the pro-apoptotic Bcl-2 family member Bok induces apoptosis.
Molecular carcinogenesis 2006;45(2):73-83.
2006: Lo Hui-Wen; Hsu Sheng-Chieh; Hung Mien-Chie
EGFR signaling pathway in breast cancers: from traditional signal transduction to direct nuclear translocalization.
Breast cancer research and treatment 2006;95(3):211-8.
2006: Li Min; Wang Yingqun; Hung Mien-Chie; Kannan Perry
Inefficient proteasomal-degradation pathway stabilizes AP-2alpha and activates HER-2/neu gene in breast cancer.
International journal of cancer. Journal international du cancer 2006;118(4):802-11.
2006: Lo H-W; Hung M-C
Nuclear EGFR signalling network in cancers: linking EGFR pathway to cell cycle progression, nitric oxide pathway and patient survival.
British journal of cancer 2006;94(2):184-8.
2006: Chen I-Fen; Ou-Yang Fu; Hung Jen-Yu; Liu Jaw-Ching; Wang Hongying; Wang Shao-Chun; Hou Ming-Feng; Hortobagyi Gabriel N; Hung Mien-Chie
AIM2 suppresses human breast cancer cell proliferation in vitro and mammary tumor growth in a mouse model.
Molecular cancer therapeutics 2006;5(1):1-7.
2006: Ou-Yang Fu; Lan Keng-Li; Chen Chun-Te; Liu Jaw-Ching; Weng Chu-Li; Chou Chao-Kai; Xie Xiaoming; Hung Jen-Yu; Wei Yongkun; Hortobagyi Gabriel N; Hung Mien-Chie
Endostatin-cytosine deaminase fusion protein suppresses tumor growth by targeting neovascular endothelial cells.
Cancer research 2006;66(1):378-84.
2006: Hanada Norihisa; Lo Hui-Wen; Day Chi-Ping; Pan Yong; Nakajima Yusuke; Hung Mien-Chie
Co-regulation of B-Myb expression by E2F1 and EGF receptor.
Molecular carcinogenesis 2006;45(1):10-7.
2005: Hung Mien-Chie; Fong Kenneth; Li Joseph K-K
Asian scientists and the "glass ceiling".
Science (New York, N.Y.) 2005;310(5755):1767-8.
2005: Giri Dipak K; Ali-Seyed Mohamed; Li Long-Yuan; Lee Dung-Fang; Ling Pin; Bartholomeusz Geoffrey; Wang Shao-Chun; Hung Mien-Chie
Endosomal transport of ErbB-2: mechanism for nuclear entry of the cell surface receptor.
Molecular and cellular biology 2005;25(24):11005-18.
2005: Wang Shao-Chun; Hung Mien-Chie
Cytoplasmic/nuclear shuttling and tumor progression.
Annals of the New York Academy of Sciences 2005;1059():11-5.
2005: Coombes Kevin R; Tsavachidis Spiridon; Morris Jeffrey S; Baggerly Keith A; Hung Mien-Chie; Kuerer Henry M
Improved peak detection and quantification of mass spectrometry data acquired from surface-enhanced laser desorption and ionization by denoising spectra with the undecimated discrete wavelet transform.
Proteomics 2005;5(16):4107-17.
2005: Cha Tai-Lung; Zhou Binhua P; Xia Weiya; Wu Yadi; Yang Cheng-Chieh; Chen Chun-Te; Ping Bo; Otte Arie P; Hung Mien-Chie
Akt-mediated phosphorylation of EZH2 suppresses methylation of lysine 27 in histone H3.
Science (New York, N.Y.) 2005;310(5746):306-10.
2005: Bisanz Kristen; Yu Jie; Edlund Magnus; Spohn Bill; Hung Mien-Chie; Chung Leland W K; Hsieh Chia-Ling
Targeting ECM-integrin interaction with liposome-encapsulated small interfering RNAs inhibits the growth of human prostate cancer in a bone xenograft imaging model.
Molecular therapy : the journal of the American Society of Gene Therapy 2005;12(4):634-43.
2005: Rau K-M; Kang H-Y; Cha T-L; Miller S A; Hung M-C
The mechanisms and managements of hormone-therapy resistance in breast and prostate cancers.
Endocrine-related cancer 2005;12(3):511-32.
2005: Bartholomeusz Chandra; Itamochi Hiroaki; Yuan Linda X H; Esteva Francisco J; Wood Christopher G; Terakawa Naoki; Hung Mien-Chie; Ueno Naoto T
Bcl-2 antisense oligonucleotide overcomes resistance to E1A gene therapy in a low HER2-expressing ovarian cancer xenograft model.
Cancer research 2005;65(18):8406-13.
2005: Ding Qingqing; Xia Weiya; Liu Jaw-Ching; Yang Jer-Yen; Lee Dung-Fang; Xia Jiahong; Bartholomeusz Geoffrey; Li Yan; Pan Yong; Li Zheng; Bargou Ralf C; Qin Jun; Lai Chien-Chen; Tsai Fuu-Jen; Tsai Chang-Hai; Hung Mien-Chie
Erk associates with and primes GSK-3beta for its inactivation resulting in upregulation of beta-catenin.
Molecular cell 2005;19(2):159-70.
2005: Lo Hui-Wen; Hsu Sheng-Chieh; Ali-Seyed Mohamed; Gunduz Mehmet; Xia Weiya; Wei Yongkun; Bartholomeusz Geoffrey; Shih Jin-Yuan; Hung Mien-Chie
Nuclear interaction of EGFR and STAT3 in the activation of the iNOS/NO pathway.
Cancer cell 2005;7(6):575-89.
2005: Zhou Binhua P; Hung Mien-Chie
Wnt, hedgehog and snail: sister pathways that control by GSK-3beta and beta-Trcp in the regulation of metastasis.
Cell cycle (Georgetown, Tex.) 2005;4(6):772-6.
2005: Hung Mien-Chie
When all colonies are blue.
Cancer biology & therapy 2005;4(5):612-4.
2005: Li Yan M; Zhou Binhua P; Deng Jiong; Pan Yong; Hay Nissim; Hung Mien-Chie
A hypoxia-independent hypoxia-inducible factor-1 activation pathway induced by phosphatidylinositol-3 kinase/Akt in HER2 overexpressing cells.
Cancer research 2005;65(8):3257-63.
2005: Shao Ruping; Lee Dung-Fang; Wen Yong; Ding Yi; Xia Weiya; Ping Bo; Yagita Hideo; Spohn Bill; Hung Mien-Chie
E1A sensitizes cancer cells to TRAIL-induced apoptosis through enhancement of caspase activation.
Molecular cancer research : MCR 2005;3(4):219-26.
2005: Kumar Rakesh; Hung Mien-Chie
Signaling intricacies take center stage in cancer cells.
Cancer research 2005;65(7):2511-5.
2005: Cha Tai-Lung; Qiu Lin; Chen Chun-Te; Wen Yong; Hung Mien-Chie
Emodin down-regulates androgen receptor and inhibits prostate cancer cell growth.
Cancer research 2005;65(6):2287-95.
2005: Dong Jinjiang; Peng Junying; Zhang Haixia; Mondesire Wallace H; Jian Weiguo; Mills Gordon B; Hung Mien-Chie; Meric-Bernstam Funda
Role of glycogen synthase kinase 3beta in rapamycin-mediated cell cycle regulation and chemosensitivity.
Cancer research 2005;65(5):1961-72.
2005: Hu Mickey C-T; Hung M C
Role of IkappaB kinase in tumorigenesis.
Future oncology (London, England) 2005;1(1):67-78.
2005: Pawlik Timothy M; Fritsche Herbert; Coombes Kevin R; Xiao Lianchun; Krishnamurthy Savitri; Hunt Kelly K; Pusztai Lajos; Chen Jeng-Neng; Clarke Charlotte H; Arun Banu; Hung Mien-Chie; Kuerer Henry M
Significant differences in nipple aspirate fluid protein expression between healthy women and those with breast cancer demonstrated by time-of-flight mass spectrometry.
Breast cancer research and treatment 2005;89(2):149-57.
2005: Lo Hui-Wen; Xia Weiya; Wei Yongkun; Ali-Seyed Mohamed; Huang Shiu-Feng; Hung Mien-Chie
Novel prognostic value of nuclear epidermal growth factor receptor in breast cancer.
Cancer research 2005;65(1):338-48.
2005: Lo Hui-Wen; Day Chi-Ping; Hung Mien-Chie
Cancer-specific gene therapy.
Advances in genetics 2005;54():235-55.
2004: Li Zheng; Day Chi-Ping; Yang Jer-Yen; Tsai Wen-Bin; Lozano Guillermina; Shih Hsiu-Ming; Hung Mien-Chie
Adenoviral E1A targets Mdm4 to stabilize tumor suppressor p53.
Cancer research 2004;64(24):9080-5.
2004: Wang Shao-Chun; Hung Mien-Chie
Finding the bEST routes to cancer.
Cancer biology & therapy 2004;3(11):1090-1.
2004: Li Yan M; Pan Yong; Wei Yongkun; Cheng Xiaoyun; Zhou Binhua P; Tan Ming; Zhou Xiaoyan; Xia Weiya; Hortobagyi Gabriel N; Yu Dihua; Hung Mien-Chie
Upregulation of CXCR4 is essential for HER2-mediated tumor metastasis.
Cancer cell 2004;6(5):459-69.
2004: Kuerer Henry M; Coombes Kevin R; Chen Jeng-Neng; Xiao Lianchun; Clarke Charlotte; Fritsche Herbert; Krishnamurthy Savitri; Marcy Sylvie; Hung Mien-Chie; Hunt Kelly K
Association between ductal fluid proteomic expression profiles and the presence of lymph node metastases in women with breast cancer.
Surgery 2004;136(5):1061-9.
2004: Chen Jin-Shing; Liu Jaw-Ching; Shen Lei; Rau Kung-Ming; Kuo Hsu-Ping; Li Yan M; Shi Daren; Lee Yung-Chie; Chang King-Jen; Hung Mien-Chie
Cancer-specific activation of the survivin promoter and its potential use in gene therapy.
Cancer gene therapy 2004;11(11):740-7.
2004: Mondesire Wallace H; Jian Weiguo; Zhang Haixia; Ensor Joe; Hung Mien-Chie; Mills Gordon B; Meric-Bernstam Funda
Targeting mammalian target of rapamycin synergistically enhances chemotherapy-induced cytotoxicity in breast cancer cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(20):7031-42.
2004: Zhou Binhua P; Deng Jiong; Xia Weiya; Xu Jihong; Li Yan M; Gunduz Mehmet; Hung Mien-Chie
Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition.
Nature cell biology 2004;6(10):931-40.
2004: Wang Shao-Chun; Lien Huang-Chun; Xia Weiya; Chen I-Fen; Lo Hui-Wen; Wang Zhiqin; Ali-Seyed Mohamed; Lee Dung-Fang; Bartholomeusz Geoffrey; Ou-Yang Fu; Giri Dipak K; Hung Mien-Chie
Binding at and transactivation of the COX-2 promoter by nuclear tyrosine kinase receptor ErbB-2.
Cancer cell 2004;6(3):251-61.
2004: Liao Yong; Hung Mien-Chie
A new role of protein phosphatase 2a in adenoviral E1A protein-mediated sensitization to anticancer drug-induced apoptosis in human breast cancer cells.
Cancer research 2004;64(17):5938-42.
2004: Liao Yong; Zou Yi-Yu; Xia Wei-Ya; Hung Mien-Chie
Enhanced paclitaxel cytotoxicity and prolonged animal survival rate by a nonviral-mediated systemic delivery of E1A gene in orthotopic xenograft human breast cancer.
Cancer gene therapy 2004;11(9):594-602.
2004: Nagata Yoichi; Lan Keng-Hsueh; Zhou Xiaoyan; Tan Ming; Esteva Francisco J; Sahin Aysegul A; Klos Kristine S; Li Ping; Monia Brett P; Nguyen Nina T; Hortobagyi Gabriel N; Hung Mien-Chie; Yu Dihua
PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients.
Cancer cell 2004;6(2):117-27.
2004: Xia Weiya; Chen Jin-Shing; Zhou Xian; Sun Pei-Rong; Lee Dung-Fang; Liao Yong; Zhou Binhua P; Hung Mien-Chie
Phosphorylation/cytoplasmic localization of p21Cip1/WAF1 is associated with HER2/neu overexpression and provides a novel combination predictor for poor prognosis in breast cancer patients.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(11):3815-24.
2004: Nahta Rita; Takahashi Takeshi; Ueno Naoto T; Hung Mien-Chie; Esteva Francisco J
P27(kip1) down-regulation is associated with trastuzumab resistance in breast cancer cells.
Cancer research 2004;64(11):3981-6.
2004: Makino Keishi; Day Chi-Ping; Wang Shao-Chun; Li Yan M; Hung Mien-Chie
Upregulation of IKKalpha/IKKbeta by integrin-linked kinase is required for HER2/neu-induced NF-kappaB antiapoptotic pathway.
Oncogene 2004;23(21):3883-7.
2004: Hu Mickey C-T; Lee Dung-Fang; Xia Weiya; Golfman Leonard S; Ou-Yang Fu; Yang Jer-Yen; Zou Yiyu; Bao Shilai; Hanada Norihisa; Saso Hitomi; Kobayashi Ryuji; Hung Mien-Chie
IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a.
Cell 2004;117(2):225-37.
2004: Nahta Rita; Hung Mien-Chie; Esteva Francisco J
The HER-2-targeting antibodies trastuzumab and pertuzumab synergistically inhibit the survival of breast cancer cells.
Cancer research 2004;64(7):2343-6.
2004: Lee Christine M; Lo Hui-Wen; Shao Ru-Ping; Wang Shao-Chun; Xia Weiya; Gershenson David M; Hung Mien-Chie
Selective activation of ceruloplasmin promoter in ovarian tumors: potential use for gene therapy.
Cancer research 2004;64(5):1788-93.
2004: Deng Jiong; Xia Weiya; Miller Stephanie A; Wen Yong; Wang Hong-Ying; Hung Mien-Chie
Crossregulation of NF-kappaB by the APC/GSK-3beta/beta-catenin pathway.
Molecular carcinogenesis 2004;39(3):139-46.
2004: Yan Duen-Hwa; Wen Yong; Su Li-Kuo; Xia Weiya; Wang Shao-Chun; Zhang Su; Gan Lin; Lee Dung-Fang; Spohn Bill; Frey Jennifer A; Hortobagyi Gabriel N; Hung Mien-Chie
A delayed chemically induced tumorigenesis in Brca2 mutant mice.
Oncogene 2004;23(10):1896-901.
2004: Noh Woo-Chul; Mondesire Wallace H; Peng Junying; Jian Weiguo; Zhang Haixia; Dong JinJiang; Mills Gordon B; Hung Mien-Chie; Meric-Bernstam Funda
Determinants of rapamycin sensitivity in breast cancer cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(3):1013-23.
2004: Royce Melanie E; Xia Weiya; Sahin Aysegul A; Katayama Hiroshi; Johnston Dennis A; Hortobagyi Gabriel; Sen Subrata; Hung Mien-Chie
STK15/Aurora-A expression in primary breast tumors is correlated with nuclear grade but not with prognosis.
Cancer 2004;100(1):12-9.
2004: Yan Duen-Hwa; Spohn Bill; Hung Mien-Chie
Delivery of DNA to tumor cells using cationic liposomes.
Methods in molecular biology (Clifton, N.J.) 2004;245():125-36.
2003: Hoque Ashraful; Carter Jennifer; Xia Weiya; Hung Mien-Chie; Sahin Aysegul A; Sen Subrata; Lippman Scott M
Loss of aurora A/STK15/BTAK overexpression correlates with transition of in situ to invasive ductal carcinoma of the breast.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2003;12(12):1518-22.
2003: Li Yan M; Wen Yong; Zhou Binhua P; Kuo Hsu-Ping; Ding Qingqing; Hung Mien-Chie
Enhancement of Bik antitumor effect by Bik mutants.
Cancer research 2003;63(22):7630-3.
2003: Zhou Binhua P; Hung Mien-Chie
Dysregulation of cellular signaling by HER2/neu in breast cancer.
Seminars in oncology 2003;30(5 Suppl 16):38-48.
2003: Lee Wei-Ping; Tai Dar-In; Tsai Sun-Lung; Yeh Chau-Ting; Chao Yee; Lee Shou-Dong; Hung Mien-Chie
Adenovirus type 5 E1A sensitizes hepatocellular carcinoma cells to gemcitabine.
Cancer research 2003;63(19):6229-36.
2003: Coombes Kevin R; Fritsche Herbert A; Clarke Charlotte; Chen Jeng-Neng; Baggerly Keith A; Morris Jeffrey S; Xiao Lian-Chun; Hung Mien-Chie; Kuerer Henry M
Quality control and peak finding for proteomics data collected from nipple aspirate fluid by surface-enhanced laser desorption and ionization.
Clinical chemistry 2003;49(10):1615-23.
2003: Liao Yong; Hung Mien-Chie
Regulation of the activity of p38 mitogen-activated protein kinase by Akt in cancer and adenoviral protein E1A-mediated sensitization to apoptosis.
Molecular and cellular biology 2003;23(19):6836-48.
2003: Wen Yong; Giri Dipak; Yan Duen-Hwa; Spohn Bill; Zinner Ralph G; Xia Weiya; Thompson Timothy C; Matusik Robert J; Hung Mien-Chie
Prostate-specific antitumor activity by probasin promoter-directed p202 expression.
Molecular carcinogenesis 2003;37(3):130-7.
2003: Chen Jin-Shing; Lan Kengli; Hung Mien-Chie
Strategies to target HER2/neu overexpression for cancer therapy.
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2003;6(3):129-36.
2003: Najafi S Mahmoud A; Li Zheng; Makino Keishi; Shao Ruping; Hung Mien-Chie
The adenoviral E1A induces p21WAF1/CIP1 expression in cancer cells.
Biochemical and biophysical research communications 2003;305(4):1099-104.
2003: Lee Christine M; Shvartsman Hyun; Deavers Michael T; Wang Shao-Chun; Xia Weiya; Schmandt Rosemarie; Bodurka Diane C; Atkinson E Neely; Malpica Anais; Gershenson David M; Hung Mien-Chie; Lu Karen H
beta-catenin nuclear localization is associated with grade in ovarian serous carcinoma.
Gynecologic oncology 2003;88(3):363-8.
2002: Kwong Ka Yin; Zou Yiyu; Day Chi-Ping; Hung Mien-Chie
The suppression of colon cancer cell growth in nude mice by targeting beta-catenin/TCF pathway.
Oncogene 2002;21(54):8340-6.
2002: Ueno Naoto T; Bartholomeusz Chandra; Xia Weiya; Anklesaria Pervin; Bruckheimer Elizabeth M; Mebel Elise; Paul Ralph; Li Song; Yo George H; Huang Leaf; Hung Mien-Chie
Systemic gene therapy in human xenograft tumor models by liposomal delivery of the E1A gene.
Cancer research 2002;62(22):6712-6.
2002: Deng Jiong; Miller Stephanie A; Wang Hong-Ying; Xia Weiya; Wen Yong; Zhou Binhua P; Li Yan; Lin Shiaw-Yih; Hung Mien-Chie
beta-catenin interacts with and inhibits NF-kappa B in human colon and breast cancer.
Cancer cell 2002;2(4):323-34.
2002: Lee Sangkyou; Yang Wentao; Lan Keng-Hsueh; Sellappan Shankar; Klos Kristine; Hortobagyi Gabriel; Hung Mien-Chie; Yu Dihua
Enhanced sensitization to taxol-induced apoptosis by herceptin pretreatment in ErbB2-overexpressing breast cancer cells.
Cancer research 2002;62(20):5703-10.
2002: Feng Zhaohui; Hu Wenwei; Chen James X; Pao Annie; Li Haiying; Rom William; Hung Mien-Chie; Tang Moon-shong
Preferential DNA damage and poor repair determine ras gene mutational hotspot in human cancer.
Journal of the National Cancer Institute 2002;94(20):1527-36.
2002: Ding Yi; Wen Yong; Spohn Bill; Wang Li; Xia Weiya; Kwong Ka Yin; Shao Ruping; Li Zheng; Hortobagyi Gabriel N; Hung Mien-Chie; Yan Duen-Hwa
Proapoptotic and antitumor activities of adenovirus-mediated p202 gene transfer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(10):3290-7.
2002: Yeh Shuyuan; Tsai Meng-Yin; Xu Qingquan; Mu Xiao-Min; Lardy Henry; Huang Ko-En; Lin Hank; Yeh Shauh-Der; Altuwaijri Saleh; Zhou Xinchang; Xing Lianping; Boyce Brendan F; Hung Mien-Chie; Zhang Su; Gan Lin; Chang Chawnshang;
Generation and characterization of androgen receptor knockout (ARKO) mice: an in vivo model for the study of androgen functions in selective tissues.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(21):13498-503.
2002: Yeh Shuyuan; Tsai Meng-Yin; Xu Qingquan; Mu Xiao-Min; Lardy Henry; Huang Ko-En; Lin Hank; Yeh Shauh-Der; Altuwaijri Saleh; Zhou Xinchang; Xing Lianping; Boyce Brendan F; Hung Mien-Chie; Zhang Su; Gan Lin; Chang Chawnshang;
Generation and characterization of androgen receptor knockout (ARKO) mice: an in vivo model for the study of androgen functions in selective tissues.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(21):13498-503.
2002: Asada Shinichi; Choi Yongmun; Yamada Masaki; Wang Shao-Chun; Hung Mien-Chie; Qin Jun; Uesugi Motonari
External control of Her2 expression and cancer cell growth by targeting a Ras-linked coactivator.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(20):12747-52.
2002: Vorburger Stephan A; Pataer Abujiang; Yoshida Kazumi; Barber Glen N; Xia Weiya; Chiao Paul; Ellis Lee M; Hung Mien-Chie; Swisher Stephen G; Hunt Kelly K
Role for the double-stranded RNA activated protein kinase PKR in E2F-1-induced apoptosis.
Oncogene 2002;21(41):6278-88.
2002: Tari Ana M; Lim Soo-Jeong; Hung Mien-Chie; Esteva Francisco J; Lopez-Berestein Gabriel
Her2/neu induces all-trans retinoic acid (ATRA) resistance in breast cancer cells.
Oncogene 2002;21(34):5224-32.
2002: Villaret Doug; Glisson Bonnie; Kenady Daniel; Hanna Ehab; Carey Mary; Gleich Lyon; Yoo George H; Futran Neal; Hung Mien-Chie; Anklesaria Pervin; Heald Alison E
A multicenter phase II study of tgDCC-E1A for the intratumoral treatment of patients with recurrent head and neck squamous cell carcinoma.
Head & neck 2002;24(7):661-9.
2002: Zhou Binhua P; Hung Mien-Chie
Novel targets of Akt, p21(Cipl/WAF1), and MDM2.
Seminars in oncology 2002;29(3 Suppl 11):62-70.
2002: Tan Ming; Jing Tong; Lan Keng-Hsueh; Neal Christopher L; Li Ping; Lee Sangkyou; Fang Dexing; Nagata Yoichi; Liu Jiaxin; Arlinghaus Ralph; Hung Mien-Chie; Yu Dihua
Phosphorylation on tyrosine-15 of p34(Cdc2) by ErbB2 inhibits p34(Cdc2) activation and is involved in resistance to taxol-induced apoptosis.
Molecular cell 2002;9(5):993-1004.
2002: Meric Funda; Hung Mien-Chie; Hortobagyi Gabriel N; Hunt Kelly K
HER2/neu in the management of invasive breast cancer.
Journal of the American College of Surgeons 2002;194(4):488-501.
2002: Feng Zhaohui; Hu Wenwei; Komissarova Elena; Pao Annie; Hung Mien-Chie; Adair Gerald M; Tang Moon-shong
Transcription-coupled DNA repair is genomic context-dependent.
The Journal of biological chemistry 2002;277(15):12777-83.
2002: Wang Shao-Chun; Shao Ruping; Pao Annie Y; Zhang Su; Hung Mien-Chie; Su Li-Kuo
Inhibition of cancer cell growth by BRCA2.
Cancer research 2002;62(5):1311-4.
2002: Cristofanilli Massimo; De Gasperis Giovanni; Zhang Lisha; Hung Mien-Chie; Gascoyne Peter R C; Hortobagyi Gabriel N
Automated electrorotation to reveal dielectric variations related to HER-2/neu overexpression in MCF-7 sublines.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(2):615-9.
2002: Meric Funda; Lee Wei-Ping; Sahin Aysegul; Zhang Haixia; Kung Hsing-Jien; Hung Mien-Chie
Expression profile of tyrosine kinases in breast cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(2):361-7.
2002: Lee Wei-Ping; Wen Yong; Varnum Brian; Hung Mien-Chie
Akt is required for Axl-Gas6 signaling to protect cells from E1A-mediated apoptosis.
Oncogene 2002;21(3):329-36.
2002: Deng Jiong; Kloosterbooer Freke; Xia Weiya; Hung Mien-Chie
The NH(2)-terminal and conserved region 2 domains of adenovirus E1A mediate two distinct mechanisms of tumor suppression.
Cancer research 2002;62(2):346-50.
2002: Deng Jiong; Zhang Haifan; Kloosterboer Freke; Liao Yong; Klostergaard Jim; Levitt Mark L; Hung Mien-Chie
Ceramide does not act as a general second messenger for ultraviolet-induced apoptosis.
Oncogene 2002;21(1):44-52.
2002: Zou Yiyu; Peng Hua; Zhou Binhua; Wen Yong; Wang Shao-Chun; Tsai Eing-Mei; Hung Mien-Chie
Systemic tumor suppression by the proapoptotic gene bik.
Cancer research 2002;62(1):8-12.
2002: Zhou Binhua P; Li Yan; Hung Mien-Chie
HER-2/Neu signaling and therapeutic approaches in breast cancer.
Breast disease 2002;15():13-24.
2001: Wang S C; Zhang L; Hortobagyi G N; Hung M C
Targeting HER2: recent developments and future directions for breast cancer patients.
Seminars in oncology 2001;28(6 Suppl 18):21-9.
2001: Zhou B P; Liao Y; Xia W; Zou Y; Spohn B; Hung M C
HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation.
Nature cell biology 2001;3(11):973-82.
2001: Wang S C; Hung M C
HER2 overexpression and cancer targeting.
Seminars in oncology 2001;28(5 Suppl 16):115-24.
2001: Wang S C; Makino K; Xia W; Kim J S; Im S A; Peng H; Mok S C; Singletary S E; Hung M C
DOC-2/hDab-2 inhibits ILK activity and induces anoikis in breast cancer cells through an Akt-independent pathway.
Oncogene 2001;20(47):6960-4.
2001: Shao R; Tsai E M; Wei K; von Lindern R; Chen Y H; Makino K; Hung M C
E1A inhibition of radiation-induced NF-kappaB activity through suppression of IKK activity and IkappaB degradation, independent of Akt activation.
Cancer research 2001;61(20):7413-6.
2001: Wen Y; Yan D H; Wang B; Spohn B; Ding Y; Shao R; Zou Y; Xie K; Hung M C
p202, an interferon-inducible protein, mediates multiple antitumor activities in human pancreatic cancer xenograft models.
Cancer research 2001;61(19):7142-7.
2001: Lin S Y; Makino K; Xia W; Matin A; Wen Y; Kwong K Y; Bourguignon L; Hung M C
Nuclear localization of EGF receptor and its potential new role as a transcription factor.
Nature cell biology 2001;3(9):802-8.
2001: Hortobagyi G N; Ueno N T; Xia W; Zhang S; Wolf J K; Putnam J B; Weiden P L; Willey J S; Carey M; Branham D L; Payne J Y; Tucker S D; Bartholomeusz C; Kilbourn R G; De Jager R L; Sneige N; Katz R L; Anklesaria P; Ibrahim N K; Murray J L; Theriault R L; Valero V; Gershenson D M; Bevers M W; Huang L; Lopez-Berestein G; Hung M C
Cationic liposome-mediated E1A gene transfer to human breast and ovarian cancer cells and its biologic effects: a phase I clinical trial.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2001;19(14):3422-33.
2001: Yang H Y; Shao R; Hung M C; Lee M H
p27 Kip1 inhibits HER2/neu-mediated cell growth and tumorigenesis.
Oncogene 2001;20(28):3695-702.
2001: Makino K; Yu D; Hung M C
Transcriptional upregulation and activation of p55Cdc via p34(cdc2) in Taxol-induced apoptosis.
Oncogene 2001;20(20):2537-43.
2001: Zhou Z; Jia S F; Hung M C; Kleinerman E S
E1A sensitizes HER2/neu-overexpressing Ewing's sarcoma cells to topoisomerase II-targeting anticancer drugs.
Cancer research 2001;61(8):3394-8.
2001: Wang S C; Makino K; Su L K; Pao A Y; Kim J S; Hung M C
Ultraviolet irradiation induces BRCA2 protein depletion through a p53-independent and protein synthesis-dependent pathway.
Cancer research 2001;61(7):2838-42.
2001: Newman L; Xia W; Yang H Y; Sahin A; Bondy M; Lukmanji F; Hung M C; Lee M H
Correlation of p27 protein expression with HER-2/neu expression in breast cancer.
Molecular carcinogenesis 2001;30(3):169-75.
2001: Zhou B P; Liao Y; Xia W; Spohn B; Lee M H; Hung M C
Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells.
Nature cell biology 2001;3(3):245-52.
2001: Zou Y; Wu Q P; Tansey W; Chow D; Hung M C; Charnsangavej C; Wallace S; Li C
Effectiveness of water soluble poly(L-glutamic acid)-camptothecin conjugate against resistant human lung cancer xenografted in nude mice.
International journal of oncology 2001;18(2):331-6.
2001: Ueno N T; Yu D; Hung M C
E1A: tumor suppressor or oncogene? Preclinical and clinical investigations of E1A gene therapy.
Breast cancer (Tokyo, Japan) 2001;8(4):285-93.
2000: Lim S J; Lopez-Berestein G; Hung M C; Lupu R; Tari A M
Grb2 downregulation leads to Akt inactivation in heregulin-stimulated and ErbB2-overexpressing breast cancer cells.
Oncogene 2000;19(54):6271-6.
2000: Yu D; Hung M C
Overexpression of ErbB2 in cancer and ErbB2-targeting strategies.
Oncogene 2000;19(53):6115-21.
2000: Wen Y; Hu M C; Makino K; Spohn B; Bartholomeusz G; Yan D H; Hung M C
HER-2/neu promotes androgen-independent survival and growth of prostate cancer cells through the Akt pathway.
Cancer research 2000;60(24):6841-5.
2000: Vadlamudi R K; Adam L; Wang R A; Mandal M; Nguyen D; Sahin A; Chernoff J; Hung M C; Kumar R
Regulatable expression of p21-activated kinase-1 promotes anchorage-independent growth and abnormal organization of mitotic spindles in human epithelial breast cancer cells.
The Journal of biological chemistry 2000;275(46):36238-44.
2000: Meric F; Liao Y; Lee W P; Pollock R E; Hung M C
Adenovirus 5 early region 1A does not induce expression of the ewing sarcoma fusion product EWS-FLI1 in breast and ovarian cancer cell lines.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(10):3832-6.
2000: Xu F; Xia W; Luo R Z; Peng H; Zhao S; Dai J; Long Y; Zou L; Le W; Liu J; Parlow A F; Hung M C; Bast R C; Yu Y
The human ARHI tumor suppressor gene inhibits lactation and growth in transgenic mice.
Cancer research 2000;60(17):4913-20.
2000: Yang H Y; Zhou B P; Hung M C; Lee M H
Oncogenic signals of HER-2/neu in regulating the stability of the cyclin-dependent kinase inhibitor p27.
The Journal of biological chemistry 2000;275(32):24735-9.
2000: Yin S; Hung M C; Goodrich D W
Adenovirus-mediated N5 gene transfer inhibits tumor cell proliferation by induction of apoptosis.
Cancer gene therapy 2000;7(7):985-90.
2000: Yu D; Hung M C
Role of erbB2 in breast cancer chemosensitivity.
BioEssays : news and reviews in molecular, cellular and developmental biology 2000;22(7):673-80.
2000: Shao R; Xia W; Hung M C
Inhibition of angiogenesis and induction of apoptosis are involved in E1A-mediated bystander effect and tumor suppression.
Cancer research 2000;60(12):3123-6.
2000: Xia W; Lau Y K; Hu M C; Li L; Johnston D A; Sheng S j; El-Naggar A; Hung M C
High tumoral maspin expression is associated with improved survival of patients with oral squamous cell carcinoma.
Oncogene 2000;19(20):2398-403.
2000: Lin S Y; Xia W; Wang J C; Kwong K Y; Spohn B; Wen Y; Pestell R G; Hung M C
Beta-catenin, a novel prognostic marker for breast cancer: its roles in cyclin D1 expression and cancer progression.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(8):4262-6.
2000: Zhou B P; Hu M C; Miller S A; Yu Z; Xia W; Lin S Y; Hung M C
HER-2/neu blocks tumor necrosis factor-induced apoptosis via the Akt/NF-kappaB pathway.
The Journal of biological chemistry 2000;275(11):8027-31.
2000: Xing X; Wang S C; Xia W; Zou Y; Shao R; Kwong K Y; Yu Z; Zhang S; Miller S; Huang L; Hung M C
The ets protein PEA3 suppresses HER-2/neu overexpression and inhibits tumorigenesis.
Nature medicine 2000;6(2):189-95.
2000: Ueno N T; Bartholomeusz C; Herrmann J L; Estrov Z; Shao R; Andreeff M; Price J; Paul R W; Anklesaria P; Yu D; Hung M C
E1A-mediated paclitaxel sensitization in HER-2/neu-overexpressing ovarian cancer SKOV3.ip1 through apoptosis involving the caspase-3 pathway.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(1):250-9.
2000: Wen Y; Yan D H; Spohn B; Deng J; Lin S Y; Hung M C
Tumor suppression and sensitization to tumor necrosis factor alpha-induced apoptosis by an interferon-inducible protein, p202, in breast cancer cells.
Cancer research 2000;60(1):42-6.
2000: Hung M C; Wang S C
Suppressing HER2/neu-mediated cell transformation by transcriptional repressors.
Breast disease 2000;11():133-44.
2000: Hung M C; Hortobagyi G N; Ueno N T
Development of clinical trial of E1A gene therapy targeting HER-2/neu-overexpressing breast and ovarian cancer.
Advances in experimental medicine and biology 2000;465():171-80.
1999: Xia W; Lau Y K; Zhang H Z; Xiao F Y; Johnston D A; Liu A R; Li L; Katz R L; Hung M C
Combination of EGFR, HER-2/neu, and HER-3 is a stronger predictor for the outcome of oral squamous cell carcinoma than any individual family members.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(12):4164-74.
1999: Lee W P; Liao Y; Robinson D; Kung H J; Liu E T; Hung M C
Axl-gas6 interaction counteracts E1A-mediated cell growth suppression and proapoptotic activity.
Molecular and cellular biology 1999;19(12):8075-82.
1999: Pusztai L; Esteva F J; Cristofanilli M; Hung M C; Hortobagyi G N
Chemo-signal therapy, an emerging new approach to modify drug resistance in breast cancer.
Cancer treatment reviews 1999;25(5):271-7.
1999: Hung M C; Lau Y K
Basic science of HER-2/neu: a review.
Seminars in oncology 1999;26(4 Suppl 12):51-9.
1999: Hortobagyi G N; Hung M C; Buzdar A U
Recent developments in breast cancer therapy.
Seminars in oncology 1999;26(4 Suppl 12):11-20.
1999: Hong R L; Spohn W H; Hung M C
Curcumin inhibits tyrosine kinase activity of p185neu and also depletes p185neu.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(7):1884-91.
1999: Shao R; Hu M C; Zhou B P; Lin S Y; Chiao P J; von Lindern R H; Spohn B; Hung M C
E1A sensitizes cells to tumor necrosis factor-induced apoptosis through inhibition of IkappaB kinases and nuclear factor kappaB activities.
The Journal of biological chemistry 1999;274(31):21495-8.
1999: Li K; Shao R; Hung M C
Collagen-homology domain 1 deletion mutant of Shc suppresses transformation mediated by neu through a MAPK-independent pathway.
Oncogene 1999;18(16):2617-26.
1999: Ueno N T; Xia W; Tucker S D; Zhang S; Lopez-Berestein G; Huang L; Hung M C
Issues in the development of gene therapy: preclinical experiments in E1A gene delivery.
Oncology reports 1999;6(2):257-62.
1999: Zhang L; Lau Y K; Xia W; Hortobagyi G N; Hung M C
Tyrosine kinase inhibitor emodin suppresses growth of HER-2/neu-overexpressing breast cancer cells in athymic mice and sensitizes these cells to the inhibitory effect of paclitaxel.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(2):343-53.
1999: Tari A M; Hung M C; Li K; Lopez-Berestein G
Growth inhibition of breast cancer cells by Grb2 downregulation is correlated with inactivation of mitogen-activated protein kinase in EGFR, but not in ErbB2, cells.
Oncogene 1999;18(6):1325-32.
1999: Yan D H; Wen Y; Spohn B; Choubey D; Gutterman J U; Hung M C
Reduced growth rate and transformation phenotype of the prostate cancer cells by an interferon-inducible protein, p202.
Oncogene 1999;18(3):807-11.
1998: Xing X; Zhang S; Chang J Y; Tucker S D; Chen H; Huang L; Hung M C
Safety study and characterization of E1A-liposome complex gene-delivery protocol in an ovarian cancer model.
Gene therapy 1998;5(11):1538-44.
1998: Yu D; Jing T; Liu B; Yao J; Tan M; McDonnell T J; Hung M C
Overexpression of ErbB2 blocks Taxol-induced apoptosis by upregulation of p21Cip1, which inhibits p34Cdc2 kinase.
Molecular cell 1998;2(5):581-91.
1998: Su L K; Wang S C; Qi Y; Luo W; Hung M C; Lin S H
Characterization of BRCA2: temperature sensitivity of detection and cell-cycle regulated expression.
Oncogene 1998;17(18):2377-81.
1998: Deng J; Xia W; Hung M C
Adenovirus 5 E1A-mediated tumor suppression associated with E1A-mediated apoptosis in vivo.
Oncogene 1998;17(17):2167-75.
1998: Kwong K Y; Hung M C
A novel splice variant of HER2 with increased transformation activity.
Molecular carcinogenesis 1998;23(2):62-8.
1998: Hortobagyi G N; Hung M C; Lopez-Berestein G
A Phase I multicenter study of E1A gene therapy for patients with metastatic breast cancer and epithelial ovarian cancer that overexpresses HER-2/neu or epithelial ovarian cancer.
Human gene therapy 1998;9(12):1775-98.
1998: Yu D; Hung M C
The erbB2 gene as a cancer therapeutic target and the tumor- and metastasis-suppressing function of E1A.
Cancer metastasis reviews 1998;17(2):195-202.
1998: Zhang L; Lau Y K; Xi L; Hong R L; Kim D S; Chen C F; Hortobagyi G N; Chang C; Hung M C
Tyrosine kinase inhibitors, emodin and its derivative repress HER-2/neu-induced cellular transformation and metastasis-associated properties.
Oncogene 1998;16(22):2855-63.
1998: Le X F; Vallian S; Mu Z M; Hung M C; Chang K S
Recombinant PML adenovirus suppresses growth and tumorigenicity of human breast cancer cells by inducing G1 cell cycle arrest and apoptosis.
Oncogene 1998;16(14):1839-49.
1998: Yu D; Liu B; Jing T; Sun D; Price J E; Singletary S E; Ibrahim N; Hortobagyi G N; Hung M C
Overexpression of both p185c-erbB2 and p170mdr-1 renders breast cancer cells highly resistant to taxol.
Oncogene 1998;16(16):2087-94.
1997: Shao R; Karunagaran D; Zhou B P; Li K; Lo S S; Deng J; Chiao P; Hung M C
Inhibition of nuclear factor-kappaB activity is involved in E1A-mediated sensitization of radiation-induced apoptosis.
The Journal of biological chemistry 1997;272(52):32739-42.
1997: Brader K R; Wolf J K; Hung M C; Yu D; Crispens M A; van Golen K L; Price J E
Adenovirus E1A expression enhances the sensitivity of an ovarian cancer cell line to multiple cytotoxic agents through an apoptotic mechanism.
Clinical cancer research : an official journal of the American Association for Cancer Research 1997;3(11):2017-24.
1997: Kiyokawa N; Karunagaran D; Lee E K; Xie Y; Yan D H; Hung M C
Involvement of cdc2-mediated phosphorylation in the cell cycle-dependent regulation of p185neu.
Oncogene 1997;15(22):2633-41.
1997: Hunt K K; Deng J; Liu T J; Wilson-Heiner M; Swisher S G; Clayman G; Hung M C
Adenovirus-mediated overexpression of the transcription factor E2F-1 induces apoptosis in human breast and ovarian carcinoma cell lines and does not require p53.
Cancer research 1997;57(21):4722-6.
1997: Liu B; Sun D; Xia W; Hung M C; Yu D
Cross-reactivity of C219 anti-p170(mdr-1) antibody with p185(c-erbB2) in breast cancer cells: cautions on evaluating p170(mdr-1)
Journal of the National Cancer Institute 1997;89(20):1524-9.
1997: Ueno N T; Yu D; Hung M C
Chemosensitization of HER-2/neu-overexpressing human breast cancer cells to paclitaxel (Taxol) by adenovirus type 5 E1A.
Oncogene 1997;15(8):953-60.
1997: Kiyokawa N; Lee E K; Karunagaran D; Lin S Y; Hung M C
Mitosis-specific negative regulation of epidermal growth factor receptor, triggered by a decrease in ligand binding and dimerization, can be overcome by overexpression of receptor.
The Journal of biological chemistry 1997;272(30):18656-65.
1997: Wang S C; Lin S H; Su L K; Hung M C
Changes in BRCA2 expression during progression of the cell cycle.
Biochemical and biophysical research communications 1997;234(1):247-51.
1997: Chen H; Yu D; Chinnadurai G; Karunagaran D; Hung M C
Mapping of adenovirus 5 E1A domains responsible for suppression of neu-mediated transformation via transcriptional repression of neu.
Oncogene 1997;14(16):1965-71.
1997: Luo W; Wood C G; Earley K; Hung M C; Lin S H
Suppression of tumorigenicity of breast cancer cells by an epithelial cell adhesion molecule (C-CAM1): the adhesion and growth suppression are mediated by different domains.
Oncogene 1997;14(14):1697-704.
1997: Xing X; Liu V; Xia W; Stephens L C; Huang L; Lopez-Berestein G; Hung M C
Safety studies of the intraperitoneal injection of E1A--liposome complex in mice.
Gene therapy 1997;4(3):238-43.
1997: Chen H; Hung M C
Involvement of co-activator p300 in the transcriptional regulation of the HER-2/neu gene.
The Journal of biological chemistry 1997;272(10):6101-4.
1997: Chang J Y; Xia W; Shao R; Sorgi F; Hortobagyi G N; Huang L; Hung M C
The tumor suppression activity of E1A in HER-2/neu-overexpressing breast cancer.
Oncogene 1997;14(5):561-8.
1997: Xia W; Lau Y K; Zhang H Z; Liu A R; Li L; Kiyokawa N; Clayman G L; Katz R L; Hung M C
Strong correlation between c-erbB-2 overexpression and overall survival of patients with oral squamous cell carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 1997;3(1):3-9.
1996: Chang J Y; Xia W; Shao R; Hung M C
Inhibition of intratracheal lung cancer development by systemic delivery of E1A.
Oncogene 1996;13(7):1405-12.
1996: Miller S J; Xing X; Xi L; Hung M C
Identification of a specific DNA region required for enhanced transcription of HER2/neu in the MDA-MB453 breast cancer cell line.
DNA and cell biology 1996;15(9):749-57.
1996: Yu D; Liu B; Tan M; Li J; Wang S S; Hung M C
Overexpression of c-erbB-2/neu in breast cancer cells confers increased resistance to Taxol via mdr-1-independent mechanisms.
Oncogene 1996;13(6):1359-65.
1996: Xing X; Matin A; Yu D; Xia W; Sorgi F; Huang L; Hung M C
Mutant SV40 large T antigen as a therapeutic agent for HER-2/neu-overexpressing ovarian cancer.
Cancer gene therapy 1996;3(3):168-74.
1996: Xie Y; Hung M C
p66Shc isoform down-regulated and not required for HER-2/neu signaling pathway in human breast cancer cell lines with HER-2/neu overexpression.
Biochemical and biophysical research communications 1996;221(1):140-5.
1996: Zhang L; Hung M C
Sensitization of HER-2/neu-overexpressing non-small cell lung cancer cells to chemotherapeutic drugs by tyrosine kinase inhibitor emodin.
Oncogene 1996;12(3):571-6.
1995: Xie Y; Pendergast A M; Hung M C
Dominant-negative mutants of Grb2 induced reversal of the transformed phenotypes caused by the point mutation-activated rat HER-2/Neu.
The Journal of biological chemistry 1995;270(51):30717-24.
1995: Beckhardt R N; Kiyokawa N; Xi L; Liu T J; Hung M C; el-Naggar A K; Zhang H Z; Clayman G L
HER-2/neu oncogene characterization in head and neck squamous cell carcinoma.
Archives of otolaryngology--head & neck surgery 1995;121(11):1265-70.
1995: Yu D; Matin A; Xia W; Sorgi F; Huang L; Hung M C
Liposome-mediated in vivo E1A gene transfer suppressed dissemination of ovarian cancer cells that overexpress HER-2/neu.
Oncogene 1995;11(7):1383-8.
1995: Tang P; Hung M C; Klostergaard J
ADP-ribosylation inhibitors inhibit cellular RNA synthesis but do not affect expression of manganous superoxide dismutase or heat shock protein 70 in tumor necrosis factor alpha-sensitive and -resistant tumor cells.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1995;15(9):791-7.
1995: Zhang L; Chang C J; Bacus S S; Hung M C
Suppressed transformation and induced differentiation of HER-2/neu-overexpressing breast cancer cells by emodin.
Cancer research 1995;55(17):3890-6.
1995: Gum R; Wang S W; Lengyel E; Yu D; Hung M C; Juarez J; Boyd D
Up-regulation of urokinase-type plasminogen activator expression by the HER2/neu proto-oncogene.
Anticancer research 1995;15(4):1167-72.
1995: Xie Y; Li K; Hung M C
Tyrosine phosphorylation of Shc proteins and formation of Shc/Grb2 complex correlate to the transformation of NIH3T3 cells mediated by the point-mutation activated neu.
Oncogene 1995;10(12):2409-13.
1995: Hung M C; Matin A; Zhang Y; Xing X; Sorgi F; Huang L; Yu D
HER-2/neu-targeting gene therapy--a review.
Gene 1995;159(1):65-71.
1995: Zhang Y; Yu D; Xia W; Hung M C
HER-2/neu-targeting cancer therapy via adenovirus-mediated E1A delivery in an animal model.
Oncogene 1995;10(10):1947-54.
1995: Kiyokawa N; Yan D H; Brown M E; Hung M C
Cell cycle-dependent regulation of p185neu: a relationship between disruption of this regulation and transformation.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(4):1092-6.
1994: Xie Y; Hung M C
Nuclear localization of p185neu tyrosine kinase and its association with transcriptional transactivation.
Biochemical and biophysical research communications 1994;203(3):1589-98.
1994: Yu D; Wang S S; Dulski K M; Tsai C M; Nicolson G L; Hung M C
c-erbB-2/neu overexpression enhances metastatic potential of human lung cancer cells by induction of metastasis-associated properties.
Cancer research 1994;54(12):3260-6.
1994: Matin A; Hung M C
The retinoblastoma gene product, Rb, represses neu expression through two regions within the neu regulatory sequence.
Oncogene 1994;9(5):1333-9.
1994: Yu D; Matin A; Hinds P W; Hung M C
Transcriptional regulation of neu by RB and E1A in rat-1 cells.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1994;5(4):431-8.
1994: Tang P; Hung M C; Klostergaard J
TNF cytotoxicity: effects of HER-2/neu expression and inhibitors of ADP-ribosylation.
Lymphokine and cytokine research 1994;13(2):117-23.
1993: Matin A; Hung M C
Negative regulation of the neu promoter by the SV40 large T antigen.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1993;4(12):1051-6.
1993: Yu D; Shi D; Scanlon M; Hung M C
Reexpression of neu-encoded oncoprotein counteracts the tumor-suppressing but not the metastasis-suppressing function of E1A.
Cancer research 1993;53(23):5784-90.
1993: Reardon D B; Hung M C
Downstream signal transduction defects that suppress transformation in two revertant cell lines expressing activated rat neu oncogene.
The Journal of biological chemistry 1993;268(24):18136-42.
1993: Donato N J; Yan D H; Hung M C; Rosenblum M G
Epidermal growth factor receptor expression and function control cytotoxic responsiveness to tumor necrosis factor in ME-180 squamous carcinoma cells.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1993;4(5):411-9.
1993: Utsumi T; Levitan A; Hung M C; Klostergaard J
Effects of truncation of human pro-tumor necrosis factor transmembrane domain on cellular targeting.
The Journal of biological chemistry 1993;268(13):9511-6.
1993: Yu D; Wolf J K; Scanlon M; Price J E; Hung M C
Enhanced c-erbB-2/neu expression in human ovarian cancer cells correlates with more severe malignancy that can be suppressed by E1A.
Cancer research 1993;53(4):891-8.
1993: Matin A; Hung M C
Repression of neu-induced clonogenicity by dimethylsulfoxide correlates with decreased levels of neu-encoded cell-surface p185 and changes in phosphotyrosine content of endogenous proteins.
Cancer letters 1993;68(1):55-60.
1993: Yan D H; Hung M C
Differential activity of the RVF enhancer element in the decreased expression of the neu oncogene in NR-6 cells versus parental Swiss Webster 3T3 cells.
Molecular carcinogenesis 1993;7(1):44-9.
1992: Russell K S; Hung M C
Transcriptional repression of the neu protooncogene by estrogen stimulated estrogen receptor.
Cancer research 1992;52(23):6624-9.
1992: Yu D; Hamada J; Zhang H; Nicolson G L; Hung M C
Mechanisms of c-erbB2/neu oncogene-induced metastasis and repression of metastatic properties by adenovirus 5 E1A gene products.
Oncogene 1992;7(11):2263-70.
1992: Yan D H; Marin M C; Hung M C
Differential expression of the neu oncogene in mouse liver and pancreatic cell lines.
Biochemical and biophysical research communications 1992;186(1):363-70.
1992: Zhao X Y; Hung M C
Negative autoregulation of the neu gene is mediated by a novel enhancer.
Molecular and cellular biology 1992;12(6):2739-48.
1992: Yu D; Matin A; Hung M C
The retinoblastoma gene product suppresses neu oncogene-induced transformation via transcriptional repression of neu.
The Journal of biological chemistry 1992;267(15):10203-6.
1992: White M R; Hung M C
Cloning and characterization of the mouse neu promoter.
Oncogene 1992;7(4):677-83.
1992: Chan J C; Scanlon M; Zhang H Z; Jia L B; Yu D H; Hung M C; French M; Eastman E M
Molecular cloning and characterization of v-mos-activated transformation-associated proteins.
The Journal of biological chemistry 1992;267(2):1099-103.
1992: Hung M C; Zhang X; Yan D H; Zhang H Z; He G P; Zhang T Q; Shi D R
Aberrant expression of the c-erbB-2/neu protooncogene in ovarian cancer.
Cancer letters 1992;61(2):95-103.
1991: Yu D H; Hung M C
Expression of activated rat neu oncogene is sufficient to induce experimental metastasis in 3T3 cells.
Oncogene 1991;6(11):1991-6.
1991: Utsumi T; Hung M C; Klostergaard J
Preparation and characterization of liposomal-lipophilic tumor necrosis factor.
Cancer research 1991;51(13):3362-6.
1991: Yan D H; Hung M C
Identification and characterization of a novel enhancer for the rat neu promoter.
Molecular and cellular biology 1991;11(4):1875-82.
1991: Yu D H; Scorsone K; Hung M C
Adenovirus type 5 E1A gene products act as transformation suppressors of the neu oncogene.
Molecular and cellular biology 1991;11(3):1745-50.
1991: Yan D H; Chang L S; Hung M C
Repressed expression of the HER-2/c-erbB-2 proto-oncogene by the adenovirus E1a gene products.
Oncogene 1991;6(2):343-5.
1991: Suen T C; Hung M C
c-myc reverses neu-induced transformed morphology by transcriptional repression.
Molecular and cellular biology 1991;11(1):354-62.
1990: Suen T C; Hung M C
Multiple cis- and trans-acting elements involved in regulation of the neu gene.
Molecular and cellular biology 1990;10(12):6306-15.
1990: Yu D; Suen T C; Yan D H; Chang L S; Hung M C
Transcriptional repression of the neu protooncogene by the adenovirus 5 E1A gene products.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(12):4499-503.
1990: Matin A; Cheng K L; Suen T C; Hung M C
Effect of glucocorticoids on oncogene transformed NIH3T3 cells.
Oncogene 1990;5(1):111-6.
1990: Saya H; Ara S; Lee P S; Ro J; Hung M C
Direct sequencing analysis of transmembrane region of human Neu gene by polymerase chain reaction.
Molecular carcinogenesis 1990;3(4):198-201.
1990: Suen T C; Rodriguez R U; Hung M C; Klostergaard J
V-abl confers resistance and growth advantage to TNF-alpha in NIH3T3 cells.
Lymphokine research 1990;9(1):15-26.
1990: Zhau H E; Zhang X; von Eschenbach A C; Scorsone K; Babaian R J; Ro J Y; Hung M C
Amplification and expression of the c-erb B-2/neu proto-oncogene in human bladder cancer.
Molecular carcinogenesis 1990;3(5):254-7.
1989: Schneider P M; Hung M C; Chiocca S M; Manning J; Zhao X Y; Fang K; Roth J A
Differential expression of the c-erbB-2 gene in human small cell and non-small cell lung cancer.
Cancer research 1989;49(18):4968-71.
1989: Zhang X; Silva E; Gershenson D; Hung M C
Amplification and rearrangement of c-erb B proto-oncogenes in cancer of human female genital tract.
Oncogene 1989;4(8):985-9.
1989: Hung M C; Yan D H; Zhao X Y
Amplification of the proto-neu oncogene facilitates oncogenic activation by a single point mutation.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(8):2545-8.
1988: Steck P A; Lee P; Hung M C; Yung W K
Expression of an altered epidermal growth factor receptor by human glioblastoma cells.
Cancer research 1988;48(19):5433-9.

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