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Mien-Chie Hung

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Jia Shen; Yan Wang; Yun Wu; Weiya Xia; Wei-Chao Chang; Chung-Hsuan Chen; Yi Du; Jennifer L Hsu; Longfei Huo; Brian P James; Yekaterina B Khotskaya; Yung Carmen Lam; Seung Oe Lim; Chang-Gong Liu; Xiuping Liu; Kotaro Nakanishi; Dinshaw J Patel; Mien-Chie Hung
EGFR modulates microRNA maturation in response to hypoxia through phosphorylation of AGO2.
Yung-Luen Yu; Wei-Jung Chang; Jia-Ni Chen; Shu-Ya Chiang; Ruey-Hwang Chou; Shu-Ching Hsieh; Jennifer L Hsu; Shih-Chieh Hung; Wei Lee; Yu-Hsuan Lin; Woei-Cherng Shyu; Yen-Ju Tseng; Chen-Shiou Wu; Cheng-Chieh Yang; Su-Peng Yeh; Mien-Chie Hung
Smurf2-mediated degradation of EZH2 enhances neuron differentiation and improves functional recovery after ischaemic stroke.
Te-Chun Hsia; Sheng-Chie Hsu; Chih-Yang Huang; Tzung-Chi Huang; Wen-Shu Chen; Yun-Ju Chen; Mien-Chie Hung; Shing-Ling Tsai; Chih-Yen Tu; Ya-Ling Wei; Ming-Hsin Yeh; Chia-Jui Yen; Meng-Chieh Yu; Yung-Luen Yu; Wei-Chien Huang
Lapatinib-mediated cyclooxygenase-2 expression via epidermal growth factor receptor/HuR interaction enhances the aggressiveness of triple-negative breast cancer cells.

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All Publications

2013: Jia Shen; Yan Wang; Yun Wu; Weiya Xia; Wei-Chao Chang; Chung-Hsuan Chen; Yi Du; Jennifer L Hsu; Longfei Huo; Brian P James; Yekaterina B Khotskaya; Yung Carmen Lam; Seung Oe Lim; Chang-Gong Liu; Xiuping Liu; Kotaro Nakanishi; Dinshaw J Patel; Mien-Chie Hung
EGFR modulates microRNA maturation in response to hypoxia through phosphorylation of AGO2.
Nature 2013;497(7449):383-7.
2013: Yung-Luen Yu; Wei-Jung Chang; Jia-Ni Chen; Shu-Ya Chiang; Ruey-Hwang Chou; Shu-Ching Hsieh; Jennifer L Hsu; Shih-Chieh Hung; Wei Lee; Yu-Hsuan Lin; Woei-Cherng Shyu; Yen-Ju Tseng; Chen-Shiou Wu; Cheng-Chieh Yang; Su-Peng Yeh; Mien-Chie Hung
Smurf2-mediated degradation of EZH2 enhances neuron differentiation and improves functional recovery after ischaemic stroke.
EMBO molecular medicine 2013;5(4):531-47.
2013: Te-Chun Hsia; Sheng-Chie Hsu; Chih-Yang Huang; Tzung-Chi Huang; Wen-Shu Chen; Yun-Ju Chen; Mien-Chie Hung; Shing-Ling Tsai; Chih-Yen Tu; Ya-Ling Wei; Ming-Hsin Yeh; Chia-Jui Yen; Meng-Chieh Yu; Yung-Luen Yu; Wei-Chien Huang
Lapatinib-mediated cyclooxygenase-2 expression via epidermal growth factor receptor/HuR interaction enhances the aggressiveness of triple-negative breast cancer cells.
Molecular pharmacology 2013;83(4):857-69.
2013: Chenfang Dong; B Mark Evers; Teresa W-M Fan; Mien-Chie Hung; Tiebang Kang; Yiwei Lin; Pawel Lorkiewicz; Sumitra Miriyala; Jian Shi; Daret St Clair; Yifan Wang; Yadi Wu; Jun Yao; Tingting Yuan; Binhua P Zhou
Loss of FBP1 by Snail-mediated repression provides metabolic advantages in basal-like breast cancer.
Cancer cell 2013;23(3):316-31.
2013: Hirohito Yamaguchi; How-Wen Ko; Ying-Nai Wang; Shih-Shin Chang; Chun-Te Chen; Yi Du; Roy Herbst; Jennifer L Hsu; Ming-Chuan Hsu; Mien-Chie Hung
Caspase-independent cell death is involved in the negative effect of EGF receptor inhibitors on cisplatin in non-small cell lung cancer cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2013;19(4):845-54.
2013: Ping Yi; Mien-Chie Hung; David M Lonard; Ray-Chang Wu; Weiya Xia; Bert W O'Malley
SRC-3 coactivator regulates cell resistance to cytotoxic stress via TRAF4-mediated p53 destabilization.
Genes & development 2013;27(3):274-87.
2013: Pei-Wen Yang; Ching-Yueh Hsieh; Mien-Chie Hung; Jui-Chang Tsai; En-Chi Tung; Ying-Hao Wang; Jang-Ming Lee
The effects of Photofrin-mediated photodynamic therapy on the modulation of EGFR in esophageal squamous cell carcinoma cells.
Lasers in medical science 2013;28(2):605-14.
2013: Shih-Pei Lin; Stephanie A Miller; Shung-Haur Yang; Shih-Hwa Chiou; Mien-Chie Hung; Yi-Ting Lee; Shih-Chieh Hung
Colon cancer stem cells resist antiangiogenesis therapy-induced apoptosis.
Cancer letters 2013;328(2):226-34.
2013: Yung-Luen Yu; Wei-Jung Chang; Ruey-Hwang Chou; Wei-Chien Huang; Jia-Hong Liang; Kuo-Jung Su; Yen-Ju Tseng; Shao-Chun Wang; Mien-Chie Hung
Targeting the EGFR/PCNA Signaling Suppresses Tumor Growth of Triple-Negative Breast Cancer Cells with Cell-Penetrating PCNA Peptides.
PloS one 2013;8(4):e61362.
2013: Wei-Chien Huang; Mien-Chie Hung
Beyond NF-κB activation: nuclear functions of IκB kinase α.
Journal of biomedical science 2013;20():3.
2013: Che-Ming Liu; Sen-Jei Lo; Leland W K Chung; Yun-Chi He; Chia-Ling Hsieh; Teng-Fu Hsieh; Mien-Chie Hung; Sajni Josson; Ji-An Liang; Shian-Ying Sung
In vivo targeting of ADAM9 gene expression using lentivirus-delivered shRNA suppresses prostate cancer growth by regulating REG4 dependent cell cycle progression.
PloS one 2013;8(1):e53795.
2012: Laisheng Li; Min Liu; Jinmei Luo; Jun Tang; Xi Wang; Weidong Wei; Minqing Wu; Shaoyan Xi; Xinhua Xie; Jie Gao; Jiaoli Guo; Mien-Chie Hung; Yanan Kong; Zeming Xie; Mingtian Yang; Xiaoming Xie
Targeted expression of miR-34a using the T-VISA system suppresses breast cancer cell growth and invasion.
Molecular therapy : the journal of the American Society of Gene Therapy 2012;20(12):2326-34.
2012: X Li; K Liang; Ying Lu; Gordon B Mills; Constance T Albarracin; Jung-Mao Hsu; Mien-Chie Hung; Z Fan
Brk/PTK6 sustains activated EGFR signaling through inhibiting EGFR degradation and transactivating EGFR.
Oncogene 2012;31(40):4372-83.
2012: Dahu Chen; Sumeet Gupta; Mien-Chie Hung; Han Liang; Hui-Kuan Lin; Abdol Hossein Rezaeian; Yutong Sun; Julie Teruya-Feldstein; Yongkun Wei; Peijing Zhang; Li Ma
LIFR is a breast cancer metastasis suppressor upstream of the Hippo-YAP pathway and a prognostic marker.
Nature medicine 2012;18(10):1511-7.
2012: Chun-Te Chen; Yi Du; Gabriel N Hortobagyi; Jung-Mao Hsu; Hsu-Ping Kuo; Hirohito Yamaguchi; Mien-Chie Hung
Targeting the IKKβ/mTOR/VEGF signaling pathway as a potential therapeutic strategy for obesity-related breast cancer.
Molecular cancer therapeutics 2012;11(10):2212-21.
2012: Yung-Luen Yu; Wei-Chao Chang; Wei-Jung Chang; Chung-Hsuan Chen; Ruey-Hwang Chou; Longfei Huo; Chien-Chen Lai; Hong-Jen Lee; Yen-Ju Tseng; Ying-Nai Wang; Chia-Han Wu; Mien-Chie Hung
Nuclear EGFR suppresses ribonuclease activity of polynucleotide phosphorylase through DNAPK-mediated phosphorylation at serine 776.
The Journal of biological chemistry 2012;287(37):31015-26.
2012: Xinhua Xie; Guoquan Gao; Jiaoli Guo; Jennifer L Hsu; Mien-Chie Hung; Yanan Kong; Laisheng Li; Wanli Liu; Weidong Wei; Minqing Wu; Xiangsheng Xiao; Xiaoming Xie
Targeted expression of BikDD eliminates breast cancer with virtually no toxicity in noninvasive imaging models.
Molecular cancer therapeutics 2012;11(9):1915-24.
2012: Dung-Fang Lee; Francesca Aguilo; Yen-Sin Ang; Xonia Carvajal-Vergara; Betty Chang; Henia Darr; Elsa R Flores; Bruce D Gelb; Julian Gingold; Mien-Chie Hung; Avi Ma'ayan; Kateri A Moore; Sonia Mulero-Navarro; Xiaohong Niu; Carlos Filipe Pereira; Christoph Schaniel; Ana Sevilla; Yuh-Pyng Sher; Hans-Willem Snoeck; Jie Su; Hung-Liang Wang; Anthony D Whetton; Andrew J K Williamson; Ruiying Zhao; Ihor R Lemischka
Regulation of embryonic and induced pluripotency by aurora kinase-p53 signaling.
Cell stem cell 2012;11(2):179-94.
2012: Mien-Chie Hung
On mammary gland growth factors: roles in normal development and in cancer.
Cold Spring Harbor perspectives in biology 2012;4(8):a013532.
2012: Radia Ouelaa-Benslama; Grégoire Prévost; Michèle Sabbah; Marc Bracke; Olivier De Wever; Shahin Emami; An Hendrix; Mien-Chie Hung; Kathleen Lambein; David Land; Annette K Larsen; Christian Gespach
Identification of a GαGβγ, AKT and PKCα signalome associated with invasive growth in two genetic models of human breast cancer cell epithelial-to-mesenchymal transition.
International journal of oncology 2012;41(1):189-200.
2012: Chia-Hsin Chan; Zizhen Feng; Leo G Flores; Yuan Gao; John D Hazle; Hsuan-Ying Huang; Mien-Chie Hung; Szu-Wei Lee; Chien-Feng Li; Keiichi I Nakayama; Dos Sarbassov; Yiping Shao; Kelvin K C Tsai; Wenyi Wei; Wei-Lei Yang; Dihua Yu; Hui-Kuan Lin
The Skp2-SCF E3 ligase regulates Akt ubiquitination, glycolysis, herceptin sensitivity, and tumorigenesis.
Cell 2012;149(5):1098-111.
2012: Ying-Nai Wang; Hirohito Yamaguchi; Yi Du; Heng-Huan Lee; Hong-Jen Lee; Mien-Chie Hung
Membrane-bound trafficking regulates nuclear transport of integral epidermal growth factor receptor (EGFR) and ErbB-2.
The Journal of biological chemistry 2012;287(20):16869-79.
2012: Wen-Hao Yang; Chi-Hung Huang; Mien-Chie Hung; Shou-Yen Kao; Hsin-Yi Lan; Shyh-Kuan Tai; Cheng-Hwai Tzeng; Kou-Juey Wu; Muh-Hwa Yang
RAC1 activation mediates Twist1-induced cancer cell migration.
Nature cell biology 2012;14(4):366-74.
2012: Yan Wang; Tsung-Teh Wu; Yun Wu; Weiya Xia; Chia-Jui Yen; Jaffer Ajani; Navtej S Buttar; Wei-Chao Chang; Chung-Hsuan Chen; Qingqing Ding; Jennifer L Hsu; Jung-Mao Hsu; Tzu-Hsuan Huang; Longfei Huo; Julie G Izzo; Adam M Labaff; Chien-Chen Lai; Jing-Yu Lang; Dung-Fang Lee; Chia-Wei Li; Dongping Liu; Stephanie A Miller; Fuu-Jen Tsai; Huamin Wang; Kenneth K Wang; Xuemei Wang; Mien-Chie Hung
The crosstalk of mTOR/S6K1 and Hedgehog pathways.
Cancer cell 2012;21(3):374-87.
2012: Chia-Wei Li; Seung-Oe Lim; Been-Ren Lin; Yan Wang; Ting-Jung Wu; Yun Wu; Weiya Xia; Hirohito Yamaguchi; Muh-Hwa Yang; Neng-Kai Yang; Chi-Hong Chao; Qingqing Ding; Gabriel N Hortobagyi; Jennifer L Hsu; Longfei Huo; Adam M LaBaff; Yun-Ju Lai; Mien-Chie Hung
Epithelial-mesenchymal transition induced by TNF-α requires NF-κB-mediated transcriptional upregulation of Twist1.
Cancer research 2012;72(5):1290-300.
2012: Mo Liu; Yongkun Wei; Weiya Xia; Chia-Jui Yen; Michael Karin; Hsu-Ping Kuo; Dung-Fang Lee; Hong-Jen Lee; Long-Yuan Li; Chun-Ju Chang; Wei-Chao Chang; Chung-Hsuan Chen; Chun-Te Chen; Pei-Chun Chiu; Chao-Kai Chou; Debanjan Dhar; Yi Du; Jung-Mao Hsu; Mien-Chie Hung
IKKα activation of NOTCH links tumorigenesis via FOXA2 suppression.
Molecular cell 2012;45(2):171-84.
2012: Jianhua Ling; Jinsong Liu; Bailu Peng; Huamin Wang; Qianghua Xia; Ruiying Zhao; Jason B Fleming; Mien-Chie Hung; Ya'an Kang; Dung-Fang Lee; Ihor R Lemischka; Jin Li; Zhe Chang; Paul J Chiao
KrasG12D-induced IKK2/β/NF-κB activation by IL-1α and p62 feedforward loops is required for development of pancreatic ductal adenocarcinoma.
Cancer cell 2012;21(1):105-20.
2012: Shih-Pei Lin; Stephanie A Miller; Jir-You Wang; Shih-Hwa Chiou; Mien-Chie Hung; Yi-Ting Lee; Shih-Chieh Hung
Survival of cancer stem cells under hypoxia and serum depletion via decrease in PP2A activity and activation of p38-MAPKAPK2-Hsp27.
PloS one 2012;7(11):e49605.
2012: Ya-Huey Chen; Mien-Chie Hung; Long-Yuan Li
EZH2: a pivotal regulator in controlling cell differentiation.
American journal of translational research 2012;4(4):364-75.
2012: Pai-Sheng Chen; Jen-Liang Su; Mien-Chie Hung
Dysregulation of microRNAs in cancer.
Journal of biomedical science 2012;19():90.
2012: Hirohito Yamaguchi; Jennifer L Hsu; Mien-Chie Hung
Regulation of ubiquitination-mediated protein degradation by survival kinases in cancer.
Frontiers in oncology 2012;2():15.
2012: Lei Nie; Yan Wang; Hsing-Ju Wu; Adam M Labaff; Chia-Wei Li; Shih-Shin Chang; Jennifer L Hsu; Jung-Mao Hsu; Mien-Chie Hung
Long non-coding RNAs: versatile master regulators of gene expression and crucial players in cancer.
American journal of translational research 2012;4(2):127-50.
2012: Ying-Nai Wang; Mien-Chie Hung
Nuclear functions and subcellular trafficking mechanisms of the epidermal growth factor receptor family.
Cell & bioscience 2012;2(1):13.
2011: Jang-Chang Lee; Kuo-Hsiung Lee; Tzong-Der Way; Li-Chen Chou; Jing-Gung Chung; Chi-Hung Huang; Li-Jiau Huang; Mien-Chie Hung; Sheng-Chu Kuo
CHM-1 induces apoptosis via p38-mediated upregulation of DR5 expression in human ovarian cancer SKOV3 cells.
European journal of pharmacology 2011;670(1):96-104.
2011: Qingqing Ding; Raymond N Dubois; Lee M Ellis; Jennifer L Hsu; Changchun Cai; Chun-Ju Chang; Libo Chen; Yun-Ju Chen; Xiaoyun Cheng; Steven A Curley; Longfei Huo; Long-Bin Jeng; Hsu-Ping Kuo; Jingyu Lang; Dung-Fang Lee; Chia-Wei Li; Huabin Li; Long-Yuan Li; Alai Tan; Shao-Chun Wang; Yan Wang; Jiahong Xia; Weiya Xia; Xiaoming Xie; Jer-Yen Yang; Chia-Jui Yen; Mien-Chie Hung
APOBEC3G promotes liver metastasis in an orthotopic mouse model of colorectal cancer and predicts human hepatic metastasis.
The Journal of clinical investigation 2011;121(11):4526-36.
2011: Jen-Liang Su; Ying-Nai Wang; Hirohito Yamaguchi; How-Wen Ko; Dung-Fang Lee; Robert C Bast; Yi-Wen Chang; Poshen B Chen; Xiaoyun Cheng; Gabriel N Hortobagyi; Chao-Feng Hou; Michael Hsiao; Jung-Mao Hsu; Kuo-Tai Hua; Mien-Chie Hung
FOXO3a-Dependent Mechanism of E1A-Induced Chemosensitization.
Cancer research 2011;71(21):6878-87.
2011: Chia-Ing Jan; Herng-Sheng Lee; Chi-Yuan Chen; Fei-Na Chen; Horng-Jyr Harn; Chi-Yang Huang; Mien-Chie Hung; Mary Ann Lou; Shin Nieh; Yi-Chen Wu; Cheng-Chia Yu; Jeng-Fan Lo
Tid1, CHIP and ErbB2 interactions and their prognostic implications for breast cancer patients.
The Journal of pathology 2011;225(3):424-37.
2011: Mien-Chie Hung; Wolfgang Link
Protein localization in disease and therapy.
Journal of cell science 2011;124(Pt 20):3381-92.
2011: Xiao-Feng Le; Weiqun Mao; Zahid H Siddik; Weiya Xia; Ahmed Ashour Ahmed; Francois Claret; Guangan He; Mien-Chie Hung; Robert C Bast
The role of p27(Kip1) in dasatinib-enhanced paclitaxel cytotoxicity in human ovarian cancer cells.
Journal of the National Cancer Institute 2011;103(18):1403-22.
2011: Jing-Yu Lang; Funda Meric-Bernstam; Qingfei Wang; Wendy A Woodward; Xiaoming Xie; Hirohito Yamaguchi; Dihua Yu; Yi Bao; Chun-Ju Chang; Gabriel N Hortobagyi; Jennifer L Hsu; Mien-Chie Hung
BikDD eliminates breast cancer initiating cells and synergizes with lapatinib for breast cancer treatment.
Cancer cell 2011;20(3):341-56.
2011: Kuo-Shu Tsai; Hsei-Wei Wang; Shung-Haur Yang; Yen-Ping Lei; Stephanie A Miller; Chih-Chien Tsai; Hsin-Wei Chen; Ling-Lan Chen; Shih-Hwa Chiou; Chih-Yuan Hsu; Mien-Chie Hung; Shih-Chieh Hung
Mesenchymal stem cells promote formation of colorectal tumors in mice.
Gastroenterology 2011;141(3):1046-56.
2011: Aditi Banerjee; Krishna Baksi; Sushanta K Banerjee; Mien-Chie Hung; Jing-Yu Lang; Krishanu Sengupta; Dipak K Banerjee
Unfolded protein response is required in nu/nu mice microvasculature for treating breast tumor with tunicamycin.
The Journal of biological chemistry 2011;286(33):29127-38.
2011: Chun-Te Chen; Yi Du; Gabriel N Hortobagyi; Jennifer L Hsu; Heng-Huan Lee; Hong-Jen Lee; Hui-Lung Sun; Yan Wang; Weiya Xia; Hirohito Yamaguchi; Edward T H Yeh; Chia-Jui Yen; Wen-Hsuan Yu; Mien-Chie Hung
Dual targeting of tumor angiogenesis and chemotherapy by endostatin-cytosine deaminase-uracil phosphoribosyltransferase.
Molecular cancer therapeutics 2011;10(8):1327-36.
2011: Jer-Yen Yang; Mien-Chie Hung
Deciphering the role of forkhead transcription factors in cancer therapy.
Current drug targets 2011;12(9):1284-90.
2011: Long-Yuan Li; Huang-Chun Lien; Haou-Tzong Ma; Yuh-Pyng Sher; Chang-Hai Tsai; Ho-Cheng Tsai; Ying-Nai Wang; Hsiuyi Chen; Hui-Yu Chen; Ya-Huey Chen; Peng-Ju Chien; Hsiao-Ju Chu; Yi-Hsien Hsieh; Chien-Chen Lai; Mien-Chie Hung
Nuclear ErbB2 enhances translation and cell growth by activating transcription of ribosomal RNA genes.
Cancer research 2011;71(12):4269-79.
2011: Wei-Chien Huang; Yun-Ju Chen; Long-Yuan Li; Ya-Ling Wei; Sheng-Chieh Hsu; Shing-Ling Tsai; Pei-Chun Chiu; Wei-Pang Huang; Ying-Nai Wang; Chung-Hsuan Chen; Wei-Chao Chang; Wen-Chang Chang; Andy Jer-En Chen; Chang-Hai Tsai; Mien-Chie Hung
Nuclear translocation of epidermal growth factor receptor by Akt-dependent phosphorylation enhances breast cancer-resistant protein expression in gefitinib-resistant cells.
The Journal of biological chemistry 2011;286(23):20558-68.
2011: Ruey-Hwang Chou; Yung-Luen Yu; Mien-Chie Hung
The roles of EZH2 in cell lineage commitment.
American journal of translational research 2011;3(3):243-50.
2011: Yuh-Pyng Sher; Shih-Jen Liu; Chun-Mien Chang; Shu-Pei Lien; Chien-Hua Chen; Zhenbo Han; Long-Yuan Li; Jin-Shing Chen; Cheng-Wen Wu; Mien-Chie Hung
Cancer-targeted BikDD gene therapy elicits protective antitumor immunity against lung cancer.
Molecular cancer therapeutics 2011;10(4):637-47.
2011: Ya-Huey Chen; Fang-Ling Yeh; Su-Peng Yeh; Haou-Tzong Ma; Shih-Chieh Hung; Mien-Chie Hung; Long-Yuan Li
Myocyte enhancer factor-2 interacting transcriptional repressor (MITR) is a switch that promotes osteogenesis and inhibits adipogenesis of mesenchymal stem cells by inactivating peroxisome proliferator-activated receptor gamma-2.
The Journal of biological chemistry 2011;286(12):10671-80.
2011: Yung-Luen Yu; Ruey-Hwang Chou; Ling-Tzu Chen; Woei-Cherng Shyu; Su-Ching Hsieh; Chen-Shiou Wu; Hong-Jie Zeng; Su-Peng Yeh; De-Ming Yang; Shih-Chieh Hung; Mien-Chie Hung
EZH2 regulates neuronal differentiation of mesenchymal stem cells through PIP5K1C-dependent calcium signaling.
The Journal of biological chemistry 2011;286(11):9657-67.
2011: Tang Jiang; Brian Grabiner; Yifan Zhu; Changying Jiang; Hongxiu Li; Yun You; Jingyu Lang; Mien-Chie Hung; Xin Lin
CARMA3 is crucial for EGFR-Induced activation of NF-κB and tumor progression.
Cancer research 2011;71(6):2183-92.
2011: Sun-Jin Kim; Jang-Seong Kim; Eun Sung Park; Ju Seog Lee; Qingtang Lin; Robert R Langley; Marva Maya; Junqin He; Seung-Wook Kim; Weihua Zhang; Krishnakumar Balasubramanian; Dominic Fan; Gordon B Mills; Mien-Chie Hung; Isaiah J Fidler
Astrocytes upregulate survival genes in tumor cells and induce protection from chemotherapy.
Neoplasia (New York, N.Y.) 2011;13(3):286-98.
2011: Chun-Ju Chang; Chi-Hong Chao; Weiya Xia; Jer-Yen Yang; Yan Xiong; Chia-Wei Li; Wen-Hsuan Yu; Sumaiyah K Rehman; Jennifer L Hsu; Heng-Huan Lee; Mo Liu; Chun-Te Chen; Dihua Yu; Mien-Chie Hung
p53 regulates epithelial-mesenchymal transition and stem cell properties through modulating miRNAs.
Nature cell biology 2011;13(3):317-23.
2011: Ines Beyer; Zongyi Li; Jonas Persson; Ying Liu; Ruan van Rensburg; Roma Yumul; Xiao-Bing Zhang; Mien-Chie Hung; André Lieber
Controlled extracellular matrix degradation in breast cancer tumors improves therapy by trastuzumab.
Molecular therapy : the journal of the American Society of Gene Therapy 2011;19(3):479-89.
2011: Jung-Mao Hsu; Chun-Te Chen; Chao-Kai Chou; Hsu-Ping Kuo; Long-Yuan Li; Chun-Yi Lin; Hong-Jen Lee; Ying-Nai Wang; Mo Liu; Hsin-Wei Liao; Bin Shi; Chien-Chen Lai; Mark T Bedford; Chang-Hai Tsai; Mien-Chie Hung
Crosstalk between Arg 1175 methylation and Tyr 1173 phosphorylation negatively modulates EGFR-mediated ERK activation.
Nature cell biology 2011;13(2):174-81.
2011: Quan-Sheng Zhu; K Rosenblatt; K-L Huang; G Lahat; R Brobey; Svetlana V Bolshakov; T Nguyen; Z Ding; R Belousov; K Bill; X Luo; Alexander Lazar; Adam Dicker; Gordon B Mills; Mien-Chie Hung; Dina lev
Vimentin is a novel AKT1 target mediating motility and invasion.
Oncogene 2011;30(4):457-70.
2011: Chun-Ju Chang; Jer-Yen Yang; Weiya Xia; Chun-Te Chen; Xiaoming Xie; Chi-Hong Chao; Wendy A Woodward; Jung-Mao Hsu; Gabriel N Hortobagyi; Mien-Chie Hung
EZH2 promotes expansion of breast tumor initiating cells through activation of RAF1-β-catenin signaling.
Cancer cell 2011;19(1):86-100.
2011: Lyndsay Vanhoy Rhodes; Sarah P Short; Nicole F Neel; Virgilio A Salvo; Yun Zhu; Steven Elliott; Yongkun Wei; Dihua Yu; Menghong Sun; Shannon E Muir; Juan P Fonseca; Melyssa R Bratton; Chris Segar; Syreeta Latatia Tilghman; Tammy Sobolik-Delmaire; Linda W Horton; Snjezana Zaja-Milatovic; Bridgette M Collins-Burow; Scott Wadsworth; Barbara S Beckman; Charles E Wood; Suzanne A W Fuqua; Kenneth P Nephew; Paul Dent; Rebecca A Worthylake; Tyler J Curiel; Mien-Chie Hung; Ann Richmond; Matthew Burow
Cytokine receptor CXCR4 mediates estrogen-independent tumorigenesis, metastasis, and resistance to endocrine therapy in human breast cancer.
Cancer research 2011;71(2):603-13.
2011: Hui Song; Chia-Wei Li; Adam M Labaff; Seung Oe Lim; Long-Yuan Li; Shu-Fen Kan; Yue Chen; Kai Zhang; Jingyu Lang; Xiaoming Xie; Yan Wang; Long-Fei Huo; Sheng-Chieh Hsu; Xiaomin Chen; Yingming Zhao; Mien-Chie Hung
Acetylation of EGF receptor contributes to tumor cell resistance to histone deacetylase inhibitors.
Biochemical and biophysical research communications 2011;404(1):68-73.
2011: Yun-Ju Chen; Chao-Kai Chou; Tse-Chuan Chou; Sheng-Chieh Hsu; Wei-Chien Huang; Kwang-Yu Chang; Wen-Chang Chang; J Jack Lee; Heather Y Lin; Wu-Chou Su; Chang-Hai Tsai; Ya-Ling Wei; Ignacio I Wistuba; Chia-Jui Yen; Ping Yuan; Mien-Chie Hung
Elevated BCRP/ABCG2 expression confers acquired resistance to gefitinib in wild-type EGFR-expressing cells.
PloS one 2011;6(6):e21428.
2011: Huajun Zhao; Yuan-Hung Lo; Li Ma; Susan E Waltz; Jerilyn K Gray; Mien-Chie Hung; Shao-Chun Wang
Targeting tyrosine phosphorylation of PCNA inhibits prostate cancer growth.
Molecular cancer therapeutics 2011;10(1):29-36.
2011: Yongkun Wei; Ya-Huey Chen; Long-Yuan Li; Jingyu Lang; Su-Peng Yeh; Bin Shi; Cheng-Chieh Yang; Jer-Yen Yang; Chun-Yi Lin; Chien-Chen Lai; Mien-Chie Hung
CDK1-dependent phosphorylation of EZH2 suppresses methylation of H3K27 and promotes osteogenic differentiation of human mesenchymal stem cells.
Nature cell biology 2011;13(1):87-94.
2010: Wen-Wei Tsai; Zhanxin Wang; Teresa T Yiu; Kadir C Akdemir; Weiya Xia; Stefan Winter; Cheng-Yu Tsai; Xiaobing Shi; Dirk Schwarzer; William Plunkett; Bruce Aronow; Or Gozani; Wolfgang Fischle; Mien-Chie Hung; Dinshaw J Patel; Michelle Craig Barton
TRIM24 links a non-canonical histone signature to breast cancer.
Nature 2010;468(7326):927-32.
2010: Xiaoyun Cheng; Weiya Xia; Jer-Yen Yang; Jennifer L Hsu; Chao-Kai Chou; Hui-Lung Sun; Shannon L Wyszomierski; Gordon B Mills; William J Muller; Dihua Yu; Mien-Chie Hung
Activation of p21(CIP1/WAF1) in mammary epithelium accelerates mammary tumorigenesis and promotes lung metastasis.
Biochemical and biophysical research communications 2010;403(1):103-7.
2010: Ying-Nai Wang; Hirohito Yamaguchi; Longfei Huo; Yi Du; Hong-Jen Lee; Heng-Huan Lee; Hongmei Wang; Jung-Mao Hsu; Mien-Chie Hung
The translocon Sec61beta localized in the inner nuclear membrane transports membrane-embedded EGF receptor to the nucleus.
The Journal of biological chemistry 2010;285(49):38720-9.
2010: Ke Liang; Francisco J Esteva; Constance Albarracin; Katherine Stemke-Hale; Yang Lu; Giampaolo Bianchini; Ching-Yi Yang; Yong Li; Xinqun Li; Chun-Te Chen; Gordon B Mills; Gabriel N Hortobagyi; John Mendelsohn; Mien-Chie Hung; Zhen Fan
Recombinant human erythropoietin antagonizes trastuzumab treatment of breast cancer cells via Jak2-mediated Src activation and PTEN inactivation.
Cancer cell 2010;18(5):423-35.
2010: Chao-Kai Chou; Nan Jing; Hirohito Yamaguchi; Pei-Hsiang Tsou; Heng-Huan Lee; Chun-Te Chen; Ying-Nai Wang; Sungmin Hong; Chin Su; Jun Kameoka; Mien-Chie Hung
Rapid detection of two-protein interaction with a single fluorophore by using a microfluidic device.
The Analyst 2010;135(11):2907-12.
2010: H Yamaguchi; C-T Chen; C-K Chou; A Pal; W Bornmann; Gabriel N Hortobagyi; Mien-Chie Hung
Adenovirus 5 E1A enhances histone deacetylase inhibitors-induced apoptosis through Egr-1-mediated Bim upregulation.
Oncogene 2010;29(41):5619-29.
2010: David Luyimbazi; Argun Akcakanat; Priscilla F McAuliffe; Li Zhang; Gopal Singh; Ana Maria Gonzalez-Angulo; Huiqin Chen; Kim-Anh Do; Yuhuan Zheng; Mien-Chie Hung; Gordon B Mills; Funda Meric-Bernstam
Rapamycin regulates stearoyl CoA desaturase 1 expression in breast cancer.
Molecular cancer therapeutics 2010;9(10):2770-84.
2010: Xiaoyun Cheng; Weiya Xia; Jer-Yen Yang; Jennifer L Hsu; Jing-Yu Lang; Chao-Kai Chou; Yi Du; Hui-Lung Sun; Shannon L Wyszomierski; Gordon B Mills; William J Muller; Dihua Yu; Mien-Chie Hung
Activation of murine double minute 2 by Akt in mammary epithelium delays mammary involution and accelerates mammary tumorigenesis.
Cancer research 2010;70(19):7684-9.
2010: Yoshihide Usami; Kyoko Goto; Jing-Yu Lang; Yoon Kim; Chin-Yu Lai; Masuo Goto; Nobuko Sakurai; Masahiko Taniguchi; Toshiyuki Akiyama; Susan L Morris-Natschke; Kenneth F Bastow; Gordon Cragg; David J Newman; Mihoyo Fujitake; Koichi Takeya; Mien-Chie Hung; Eva Y-H P Lee; Kuo-Hsiung Lee
Antitumor Agents. 282. 2'-(R)-O-acetylglaucarubinone, a quassinoid from Odyendyea gabonensis as a potential anti-breast and anti-ovarian cancer agent.
Journal of natural products 2010;73(9):1553-8.
2010: Longfei Huo; Ying-Nai Wang; Weiya Xia; Sheng-Chieh Hsu; Chien-Chen Lai; Long-Yuan Li; Wei-Chao Chang; Yan Wang; Ming-Chuan Hsu; Yung-Luen Yu; Tzu-Hsuan Huang; Qingqing Ding; Chung-Hsuan Chen; Chang-Hai Tsai; Mien-Chie Hung
RNA helicase A is a DNA-binding partner for EGFR-mediated transcriptional activation in the nucleus.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(37):16125-30.
2010: Ying-Nai Wang; Hongmei Wang; Hirohito Yamaguchi; Hong-Jen Lee; Heng-Huan Lee; Mien-Chie Hung
COPI-mediated retrograde trafficking from the Golgi to the ER regulates EGFR nuclear transport.
Biochemical and biophysical research communications 2010;399(4):498-504.
2010: Chao-Kai Chou; Nan Jing; Hirohito Yamaguchi; Pei-Hsiang Tsou; Heng-Huan Lee; Chun-Te Chen; Ying-Nai Wang; Sungmin Hong; Chin Su; Jun Kameoka; Mien-Chie Hung
High speed digital protein interaction analysis using microfluidic single molecule detection system.
Lab on a chip 2010;10(14):1793-8.
2010: Y-N Wang; H Yamaguchi; Jung-Mao Hsu; Mien-Chie Hung
Nuclear trafficking of the epidermal growth factor receptor family membrane proteins.
Oncogene 2010;29(28):3997-4006.
2010: Jen-Liang Su; Poshen B Chen; Ya-Huey Chen; Shang-Chih Chen; Yi-Wen Chang; Yi-Hua Jan; Xiaoyun Cheng; Michael Hsiao; Mien-Chie Hung
Downregulation of microRNA miR-520h by E1A contributes to anticancer activity.
Cancer research 2010;70(12):5096-108.
2010: Gong Yang; Bin Chang; Fan Yang; Xiaoqing Guo; Kathy Qi Cai; Xue Sherry Xiao; Huamin Wang; Subrata Sen; Mien-Chie Hung; Gordon B Mills; Sandy Chang; Asha S Multani; Imelda Mercado-Uribe; Jinsong Liu
Aurora kinase A promotes ovarian tumorigenesis through dysregulation of the cell cycle and suppression of BRCA2.
Clinical cancer research : an official journal of the American Association for Cancer Research 2010;16(12):3171-81.
2010: Jer-Yen Yang; Chun-Ju Chang; Weiya Xia; Yan Wang; Kwok-Kin Wong; Jeffrey A Engelman; Yi Du; Michael Andreeff; Gabriel N Hortobagyi; Mien-Chie Hung
Activation of FOXO3a is sufficient to reverse mitogen-activated protein/extracellular signal-regulated kinase kinase inhibitor chemoresistance in human cancer.
Cancer research 2010;70(11):4709-18.
2010: Chia-Hsin Chan; Szu-Wei Lee; Chien-Feng Li; Jing Wang; Wei-Lei Yang; Ching-Yuan Wu; Juan Wu; Keiichi I Nakayama; Hong-Yo Kang; Hsuan-Ying Huang; Mien-Chie Hung; Pier Paolo Pandolfi; Hui-Kuan Lin
Deciphering the transcriptional complex critical for RhoA gene expression and cancer metastasis.
Nature cell biology 2010;12(5):457-67.
2010: Tiffany G Bredfeldt; K Leigh Greathouse; Stephen H Safe; Mien-Chie Hung; Mark T Bedford; Cheryl L Walker
Xenoestrogen-induced regulation of EZH2 and histone methylation via estrogen receptor signaling to PI3K/AKT.
Molecular endocrinology (Baltimore, Md.) 2010;24(5):993-1006.
2010: Weiguo Zhang; Marina Konopleva; Jared K Burks; Karen C Dywer; Wendy D Schober; Jer-Yen Yang; Teresa J McQueen; Mien-Chie Hung; Michael Andreeff
Blockade of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase and murine double minute synergistically induces Apoptosis in acute myeloid leukemia via BH3-only proteins Puma and Bim.
Cancer research 2010;70(6):2424-34.
2010: Yizhou Dong; Qian Shi; Huei-Chen Pai; Chieh-Yu Peng; Shiow-Lin Pan; Che-Ming Teng; Kyoko Goto; Donglei Yu; Yi-Nan Liu; Pei-Chi Wu; Kenneth F Bastow; Susan L Morris-Natschke; Arnold Brossi; Jing-Yu Lang; Jennifer L Hsu; Mien-Chie Hung; Eva Y-H P Lee; Kuo-Hsiung Lee
Antitumor agents. 272. Structure-activity relationships and in vivo selective anti-breast cancer activity of novel neo-tanshinlactone analogues.
Journal of medicinal chemistry 2010;53(5):2299-308.
2010: Francisco J Esteva; Dihua Yu; Mien-Chie Hung; Gabriel N Hortobagyi
Molecular predictors of response to trastuzumab and lapatinib in breast cancer.
Nature reviews. Clinical oncology 2010;7(2):98-107.
2010: Yizhou Dong; Qian Shi; Kyoko Goto; Pei-Chi Wu; Susan L Morris-Natschke; Arnold Brossi; Kenneth F Bastow; Jing-Yu Lang; Mien-Chie Hung; Kuo-Hsiung Lee
Antitumor agents 270. Novel substituted 6-phenyl-4H-furo[3,2-c]pyran-4-one derivatives as potent and highly selective anti-breast cancer agents.
Bioorganic & medicinal chemistry 2010;18(2):803-8.
2010: Quanri Jin; Linda X Yuan; Delphine Boulbes; Jong Min Baek; Ying-Nai Wang; Daniel Gomez-Cabello; David H Hawke; Sai Ching Yeung; Mong-Hong Lee; Gabriel N Hortobagyi; Mien-Chie Hung; Francisco J Esteva
Fatty acid synthase phosphorylation: a novel therapeutic target in HER2-overexpressing breast cancer cells.
Breast cancer research : BCR 2010;12(6):R96.
2010: Wen-Hwa Lee; Mien-Chie Hung; Kenneth A Iczkowski; Lucia R Languino; Steven M Dubinett; Dengshun Wang
Editorial Board 2010 American Journal of Translational Research (ISSN 1943-8141): www.ajtr.org Publisher: e-Century Publishing Corporation (www.e-Century.org).
American journal of translational research 2010;2(4):458-62.
2010: Kristina Subik; Jin-Feng Lee; Laurie Baxter; Tamera Strzepek; Dawn Costello; Patti Crowley; Lianping Xing; Mien-Chie Hung; Thomas Bonfiglio; David G Hicks; Ping Tang
The Expression Patterns of ER, PR, HER2, CK5/6, EGFR, Ki-67 and AR by Immunohistochemical Analysis in Breast Cancer Cell Lines.
Breast cancer : basic and clinical research 2010;4():35-41.
2010: Guy Lahat; Quan-Sheng Zhu; Kai-Lieh Huang; Suizhao Wang; Svetlana Bolshakov; Jeffery Liu; Keila Torres; Robert R Langley; Alexander Lazar; Mien-Chie Hung; Dina lev
Vimentin is a novel anti-cancer therapeutic target; insights from in vitro and in vivo mice xenograft studies.
PloS one 2010;5(4):e10105.
2010: Hsu-Ping Kuo; Mien-Chie Hung
Arrest-defective-1 protein (ARD1): tumor suppressor or oncoprotein?
American journal of translational research 2010;2(1):56-64.
2010: Yong Liao; Mien-Chie Hung
Physiological regulation of Akt activity and stability.
American journal of translational research 2010;2(1):19-42.
2010: Hsu-Ping Kuo; Dung-Fang Lee; Chun-Te Chen; Mo Liu; Chao-Kai Chou; Hong-Jen Lee; Yi Du; Xiaoming Xie; Yongkun Wei; Weiya Xia; Zhang Weihua; Jer-Yen Yang; Chia-Jui Yen; Tzu-Hsuan Huang; Minjia Tan; Gang Xing; Yingming Zhao; Chien-Hsing Lin; Shih-Feng Tsai; Isaiah J Fidler; Mien-Chie Hung
ARD1 stabilization of TSC2 suppresses tumorigenesis through the mTOR signaling pathway.
Science signaling 2010;3(108):ra9.
2009: Fabrice Andre; Weiya Xia; R Conforti; Yongkun Wei; Thomas Boulet; Gorana Tomasic; Marc Spielmann; Moustafa Zoubir; Narjiss Berrada; Rodrigo Arriagada; Gabriel N Hortobagyi; Mien-Chie Hung; Lajos Pusztai; Suzette Delaloge; Stefan Michiels; Massimo Cristofanilli
CXCR4 expression in early breast cancer and risk of distant recurrence.
The oncologist 2009;14(12):1182-8.
2009: Hsu-Ping Kuo; Dung-Fang Lee; Weiya Xia; Yongkun Wei; Mien-Chie Hung
TNFalpha induces HIF-1alpha expression through activation of IKKbeta.
Biochemical and biophysical research communications 2009;389(4):640-4.
2009: Hsu-Ping Kuo; Dung-Fang Lee; Weiya Xia; Chien-Chen Lai; Long-Yuan Li; Mien-Chie Hung
Phosphorylation of ARD1 by IKKbeta contributes to its destabilization and degradation.
Biochemical and biophysical research communications 2009;389(1):156-61.
2009: Shao-Chun Wang; Mien-Chie Hung
Nuclear translocation of the epidermal growth factor receptor family membrane tyrosine kinase receptors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(21):6484-9.
2009: Dongwei Zhang; Tiffany A Lafortune; Savitri Krishnamurthy; Francisco J Esteva; Massimo Cristofanilli; Ping Liu; Anthony Lucci; Balraj Singh; Mien-Chie Hung; Gabriel N Hortobagyi; Naoto T Ueno
Epidermal growth factor receptor tyrosine kinase inhibitor reverses mesenchymal to epithelial phenotype and inhibits metastasis in inflammatory breast cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(21):6639-48.
2009: Chao-Kai Chou; Dung-Fang Lee; Hui-Lung Sun; Long-Yuan Li; Chun-Yi Lin; Wei-Chien Huang; Jung-Mao Hsu; Hsu-Ping Kuo; Hirohito Yamaguchi; Ying-Nai Wang; Mo Liu; Hsin-Yi Wu; Pao-Chi Liao; Chia-Jui Yen; Mien-Chie Hung
The suppression of MAD1 by AKT-mediated phosphorylation activates MAD1 target genes transcription.
Molecular carcinogenesis 2009;48(11):1048-58.
2009: Vladislava O Melnikova; Krishnakumar Balasubramanian; Gabriel J Villares; Andrey S Dobroff; Maya Zigler; Hua Wang; Frederik Petersson; Janet E Price; Alan Schroit; Victor G Prieto; Mien-Chie Hung; Menashe Bar-Eli
Crosstalk between protease-activated receptor 1 and platelet-activating factor receptor regulates melanoma cell adhesion molecule (MCAM/MUC18) expression and melanoma metastasis.
The Journal of biological chemistry 2009;284(42):28845-55.
2009: Dung-Fang Lee; Hsu-Ping Kuo; Mo Liu; Chao-Kai Chou; Weiya Xia; Yi Du; Jia Shen; Chun-Te Chen; Longfei Huo; Ming-Chuan Hsu; Chia-Wei Li; Qingqing Ding; Tsai-Lien Liao; Chien-Chen Lai; Ann-Chi Lin; Ya-Hui Chang; Shih-Feng Tsai; Long-Yuan Li; Mien-Chie Hung
KEAP1 E3 ligase-mediated downregulation of NF-kappaB signaling by targeting IKKbeta.
Molecular cell 2009;36(1):131-40.
2009: Y-P Sher; T-F Tzeng; S-F Kan; J Hsu; X Xie; Z Han; W-C Lin; L-Y Li; Mien-Chie Hung
Cancer targeted gene therapy of BikDD inhibits orthotopic lung cancer growth and improves long-term survival.
Oncogene 2009;28(37):3286-95.
2009: Jing Lu; Hua Guo; Warapen Treekitkarnmongkol; Ping Li; Jian Zhang; Bin Shi; Chen Ling; Xiaoyan Zhou; Tongzhen Chen; Paul J Chiao; Xin-Hua Feng; Victoria L Seewaldt; William J Muller; Aysegul Sahin; Mien-Chie Hung; Dihua Yu
14-3-3zeta Cooperates with ErbB2 to promote ductal carcinoma in situ progression to invasive breast cancer by inducing epithelial-mesenchymal transition.
Cancer cell 2009;16(3):195-207.
2009: Sao Jiralerspong; Ana M Gonzalez-Angulo; Mien-Chie Hung
Expanding the arsenal: metformin for the treatment of triple-negative breast cancer?
Cell cycle (Georgetown, Tex.) 2009;8(17):2681.
2009: Xiaoming Xie; Jennifer L Hsu; Min Gew Choi; Weiya Xia; Hirohito Yamaguchi; Chun-Te Chen; Bon Q Trinh; Zhen Lu; Naoto T Ueno; Judith K Wolf; Robert C Bast; Mien-Chie Hung
A novel hTERT promoter-driven E1A therapeutic for ovarian cancer.
Molecular cancer therapeutics 2009;8(8):2375-82.
2009: Hui-Lung Sun; An-Chi Tsai; Shiow-Lin Pan; Qingqing Ding; Hirohito Yamaguchi; Chun-Nan Lin; Mien-Chie Hung; Che-Ming Teng
EPOX inhibits angiogenesis by degradation of Mcl-1 through ERK inactivation.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(15):4904-14.
2009: Sao Jiralerspong; Shana L Palla; Sharon H Giordano; Funda Meric-Bernstam; Cornelia Liedtke; Chad M Barnett; Limin Hsu; Mien-Chie Hung; Gabriel N Hortobagyi; Ana M Gonzalez-Angulo
Metformin and pathologic complete responses to neoadjuvant chemotherapy in diabetic patients with breast cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2009;27(20):3297-302.
2009: Yong Liao; Yongkun Wei; X Zhou; Jer-Yen Yang; C Dai; Y-J Chen; N K Agarwal; Dos D. Sarbassov; D Shi; Dihua Yu; Mien-Chie Hung
Peptidyl-prolyl cis/trans isomerase Pin1 is critical for the regulation of PKB/Akt stability and activation phosphorylation.
Oncogene 2009;28(26):2436-45.
2009: Weiya Xia; Yongkun Wei; Yi Du; Jinsong Liu; Bin Chang; Yung-Luen Yu; Long-Fei Huo; Stephanie Miller; Mien-Chie Hung
Nuclear expression of epidermal growth factor receptor is a novel prognostic value in patients with ovarian cancer.
Molecular carcinogenesis 2009;48(7):610-7.
2009: Shuying Liu; Makiko Umezu-Goto; Mandi Murph; Yiling Lu; Wenbin Liu; Fan Zhang; Shuangxing Yu; L Clifton Stephens; Xiaojiang Cui; George Murrow; Kevin Coombes; William Muller; Mien-Chie Hung; Charles M Perou; Adrian V Lee; Xianjun Fang; Gordon B Mills
Expression of autotaxin and lysophosphatidic acid receptors increases mammary tumorigenesis, invasion, and metastases.
Cancer cell 2009;15(6):539-50.
2009: Xiaoyun Cheng; Mien-Chie Hung
Regulation of breast cancer metastasis by atypical chemokine receptors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(9):2951-3.
2009: Hirohito Yamaguchi; Nicholas T Woods; Landon G Piluso; Heng-Huan Lee; Jiandong Chen; Kapil N Bhalla; Alvaro Monteiro; Xuan Liu; Mien-Chie Hung; Hong-Gang Wang
p53 acetylation is crucial for its transcription-independent proapoptotic functions.
The Journal of biological chemistry 2009;284(17):11171-83.
2009: Christopher L Neal; Jun Yao; Wentao Yang; Xiaoyan Zhou; Nina T Nguyen; Jing Lu; Christopher G Danes; Hua Guo; Keng-Hsueh Lan; Joe Ensor; Walter Hittelman; Mien-Chie Hung; Dihua Yu
14-3-3zeta overexpression defines high risk for breast cancer recurrence and promotes cancer cell survival.
Cancer research 2009;69(8):3425-32.
2009: Valerie S Hawthorne; Wen-Chien Huang; Christopher L Neal; Ling-Min Tseng; Mien-Chie Hung; Dihua Yu
ErbB2-mediated Src and signal transducer and activator of transcription 3 activation leads to transcriptional up-regulation of p21Cip1 and chemoresistance in breast cancer cells.
Molecular cancer research : MCR 2009;7(4):592-600.
2009: Wei-Chien Huang; Mien-Chie Hung
Induction of Akt activity by chemotherapy confers acquired resistance.
Journal of the Formosan Medical Association = Taiwan yi zhi 2009;108(3):180-94.
2009: Mien-Chie Hung; Gordon B Mills; Dihua Yu
Oxygen sensor boosts growth factor signaling.
Nature medicine 2009;15(3):246-7.
2009: Michelle A T Hildebrandt; Hushan Yang; Mien-Chie Hung; Julie G Izzo; Maosheng Huang; Jie Lin; Jaffer A Ajani; Xifeng Wu
Genetic variations in the PI3K/PTEN/AKT/mTOR pathway are associated with clinical outcomes in esophageal cancer patients treated with chemoradiotherapy.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2009;27(6):857-71.
2009: Shumei Song; Nachman Mazurek; Chunming Liu; Yunjie Sun; Qing Qing Ding; Kaifeng Liu; Mien-Chie Hung; Robert S Bresalier
Galectin-3 mediates nuclear beta-catenin accumulation and Wnt signaling in human colon cancer cells by regulation of glycogen synthase kinase-3beta activity.
Cancer research 2009;69(4):1343-9.
2009: Jer-Yen Yang; Mien-Chie Hung
A new fork for clinical application: targeting forkhead transcription factors in cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(3):752-7.
2009: Wen-Hwa Lee; Mien-Chie Hung; Kenneth A Iczkowski; Lucia R Languino; Steven M Dubinett; Dengshun Wang
The launch of the american journal of translational research.
American journal of translational research 2009;1(1):i.
2009: Wen-Hwa Lee; Mien-Chie Hung; Kenneth A Iczkowski; Lucia R Languino; Steven M Dubinett; Dengshun Wang
Editorial Board 2009: American Journal of Translational Research (ISSN 1943-8141) www.ajtr.orgPublisher: e-Century Publishing Corporation (www.e-Century.org).
American journal of translational research 2009;1(4):412-4.
2009: Sheng-Chieh Hsu; Stephanie A Miller; Yan Wang; Mien-Chie Hung
Nuclear EGFR is required for cisplatin resistance and DNA repair.
American journal of translational research 2009;1(3):249-58.
2009: Julie G Izzo; Xifeng Wu; Tsung-Teh Wu; P Huang; Ju Seog Lee; Zhongxing Liao; Jeffrey H Lee; M S Bhutani; Wayne L Hofstetter; D Maru; Mien-Chie Hung; J A Ajani
Therapy-induced expression of NF-kappaB portends poor prognosis in patients with localized esophageal cancer undergoing preoperative chemoradiation.
Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus / I.S.D.E 2009;22(2):127-32.
2008: Cathy Lee; Jaspreet Dhillon; Michelle Y C Wang; Yuanyuan Gao; Kaiji Hu; Eugene Park; Arezoo Astanehe; Mien-Chie Hung; Peter Eirew; Connie J Eaves; Sandra E Dunn
Targeting YB-1 in HER-2 overexpressing breast cancer cells induces apoptosis via the mTOR/STAT3 pathway and suppresses tumor growth in mice.
Cancer research 2008;68(21):8661-6.
2008: Dung-Fang Lee; Hsu-Ping Kuo; Chun-Te Chen; Yongkun Wei; Chao-Kai Chou; Jen-Yu Hung; Chia-Jui Yen; Mien-Chie Hung
IKKbeta suppression of TSC1 function links the mTOR pathway with insulin resistance.
International journal of molecular medicine 2008;22(5):633-8.
2008: Rui-Hong Wang; Yin Zheng; Hyun-Seok Kim; Xiaoling Xu; Liu Cao; Tyler Luhasen; Mi-Hye Lee; Cuiying Xiao; Athanassios Vassilopoulos; Weiping Chen; Kevin Gardner; Yan-Gao Man; Mien-Chie Hung; TOREN FINKEL; Chu-Xia Deng
Interplay among BRCA1, SIRT1, and Survivin during BRCA1-associated tumorigenesis.
Molecular cell 2008;32(1):11-20.
2008: Hirohito Yamaguchi; Yi Ding; Jin-Fong Lee; Ming Zhang; Ashutosh Pal; William Bornmann; Duen-Hwa Yan; Mien-Chie Hung
Interferon-inducible protein IFIXalpha inhibits cell invasion by upregulating the metastasis suppressor maspin.
Molecular carcinogenesis 2008;47(10):739-43.
2008: Dung-Fang Lee; Mien-Chie Hung
Advances in targeting IKK and IKK-related kinases for cancer therapy.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(18):5656-62.
2008: Yongkun Wei; Weiya Xia; Zhihong Zhang; Jinsong Liu; Huamin Wang; Nazmi V Adsay; Constance Albarracin; Dihua Yu; James L Abbruzzese; Gordon B Mills; Robert C Bast; Gabriel N Hortobagyi; Mien-Chie Hung
Loss of trimethylation at lysine 27 of histone H3 is a predictor of poor outcome in breast, ovarian, and pancreatic cancers.
Molecular carcinogenesis 2008;47(9):701-6.
2008: Qingqing Ding; Longfei Huo; Jer-Yen Yang; Weiya Xia; Yongkun Wei; Yong Liao; Chun-Ju Chang; Y Yang; Chien-Chen Lai; Dung-Fang Lee; Chia-Jui Yen; Yun-Ju Rita Chen; Jung-Mao Hsu; Hsu-Ping Kuo; Chun-Yi Lin; Fuu-Jen Tsai; Long-Yuan Li; Chang-Hai Tsai; Mien-Chie Hung
Down-regulation of myeloid cell leukemia-1 through inhibiting Erk/Pin 1 pathway by sorafenib facilitates chemosensitization in breast cancer.
Cancer research 2008;68(15):6109-17.
2008: Katherine Stemke-Hale; Ana Maria Gonzalez-Angulo; Ana Lluch; Richard M Neve; Wen-Lin Kuo; Michael Davies; Mark Carey; Zhi Hu; Yinghui Guan; Aysegul Sahin; W Fraser Symmans; Lajos Pusztai; Laura K Nolden; Hugo Horlings; Katrien Berns; Mien-Chie Hung; Marc J van de Vijver; Vicente Valero; Joe Gray; René Bernards; Gordon B Mills; Bryan T. J. Hennessy
An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer.
Cancer research 2008;68(15):6084-91.
2008: Jen-Liang Su; Pai-Sheng Chen; Ming-Hsien Chien; Poshen B Chen; Ya-Huey Chen; Chien-Chen Lai; Mien-Chie Hung; Min-Liang Kuo
Further evidence for expression and function of the VEGF-C/VEGFR-3 axis in cancer cells.
Cancer cell 2008;13(6):557-60.
2008: Weihua Zhang; Rachel Tsan; Huang Wei-Chien; Qiuyu Wu; Chao-Hua Chiu; Isaiah J Fidler; Mien-Chie Hung
Survival of cancer cells is maintained by EGFR independent of its kinase activity.
Cancer cell 2008;13(5):385-93.
2008: Chia-Jui Yen; Julie G Izzo; Dung-Fang Lee; Sushovan Guha; Yongkun Wei; Tsung-Teh Wu; Chun-Te Chen; Hsu-Ping Kuo; Jung-Mao Hsu; Hui-Lung Sun; Chao-Kai Chou; Navtej S Buttar; Kenneth K Wang; Peng Huang; Jaffer Ajani; Mien-Chie Hung
Bile acid exposure up-regulates tuberous sclerosis complex 1/mammalian target of rapamycin pathway in Barrett's-associated esophageal adenocarcinoma.
Cancer research 2008;68(8):2632-40.
2008: Jer-Yen Yang; Cong S Zong; Weiya Xia; Hirohito Yamaguchi; Qingqing Ding; Xiaoming Xie; Jing-Yu Lang; Chien-Chen Lai; Chun-Ju Chang; Huang Wei-Chien; Hsin Huang; Hsu-Ping Kuo; Dung-Fang Lee; Long-Yuan Li; Huang-Chun Lien; Xiaoyun Cheng; King-Jen Chang; Chwan-Deng Hsiao; Fuu-Jen Tsai; Chang-Hai Tsai; Aysegul A Sahin; William J Muller; Gordon B Mills; Dihua Yu; Gabriel N Hortobagyi; Mien-Chie Hung
ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation.
Nature cell biology 2008;10(2):138-48.
2008: Tiebang Kang; Yongkun Wei; Yuchi Honaker; Hiroshi Yamaguchi; Ettore Appella; Mien-Chie Hung; Helen Piwnica-Worms
GSK-3 beta targets Cdc25A for ubiquitin-mediated proteolysis, and GSK-3 beta inactivation correlates with Cdc25A overproduction in human cancers.
Cancer cell 2008;13(1):36-47.
2007: Dung-Fang Lee; Mien-Chie Hung
All roads lead to mTOR: integrating inflammation and tumor angiogenesis.
Cell cycle (Georgetown, Tex.) 2007;6(24):3011-4.
2007: Huang-Chun Lien; Y H Hsiao; Y S Lin; Yu-Tung Yao; Hsueh-Fen Juan; Wen-Hung Kuo; Mien-Chie Hung; King-Jen Chang; Fon-Jou Hsieh
Molecular signatures of metaplastic carcinoma of the breast by large-scale transcriptional profiling: identification of genes potentially related to epithelial-mesenchymal transition.
Oncogene 2007;26(57):7859-71.
2007: Xiaoyun Cheng; Mien-Chie Hung
Breast cancer brain metastases.
Cancer metastasis reviews 2007;26(3-4):635-43.
2007: Argun Akcakanat; Gopal Singh; Mien-Chie Hung; Funda Meric-Bernstam
Rapamycin regulates the phosphorylation of rictor.
Biochemical and biophysical research communications 2007;362(2):330-3.
2007: Hui Wen Lo; Sheng-Chieh Hsu; Weiya Xia; Xinyu Cao; Jin-Yuan Shih; Yongkun Wei; James L Abbruzzese; Gabriel N Hortobagyi; Mien-Chie Hung
Epidermal growth factor receptor cooperates with signal transducer and activator of transcription 3 to induce epithelial-mesenchymal transition in cancer cells via up-regulation of TWIST gene expression.
Cancer research 2007;67(19):9066-76.
2007: Kyoko Goto; Koji Yamada; Seikou Nakamura; Tzu-Hsuan Chen; Po-Cheng Chiang; Kenneth F Bastow; Shao-Chun Wang; Bill Spohn; Mien-Chie Hung; Fang-Yu Lee; Fang-Chen Lee; Kuo-Hsiung Lee
Antitumor agents. 258. Syntheses and evaluation of dietary antioxidant--taxoid conjugates as novel cytotoxic agents.
Bioorganic & medicinal chemistry letters 2007;17(18):5204-9.
2007: Dung-Fang Lee; Hsu-Ping Kuo; Chun-Te Chen; Jung-Mao Hsu; Chao-Kai Chou; Yongkun Wei; Hui-Lung Sun; Long-Yuan Li; Bo Ping; Huang Wei-Chien; Xianghuo He; Jen-Yu Hung; Chien-Chen Lai; Qingqing Ding; Jen-Liang Su; Jer-Yen Yang; Aysegul A Sahin; Gabriel N Hortobagyi; Fuu-Jen Tsai; Chang-Hai Tsai; Mien-Chie Hung
IKK beta suppression of TSC1 links inflammation and tumor angiogenesis via the mTOR pathway.
Cell 2007;130(3):440-55.
2007: Joan S Brugge; Mien-Chie Hung; Gordon B Mills
A new mutational AKTivation in the PI3K pathway.
Cancer cell 2007;12(2):104-7.
2007: Xianhui Wang; Mingzhe Zheng; Gang Liu; Weiya Xia; Paula J McKeown-Longo; Mien-Chie Hung; Jihe Zhao
Krüppel-like factor 8 induces epithelial to mesenchymal transition and epithelial cell invasion.
Cancer research 2007;67(15):7184-93.
2007: Xiaoming Xie; Weiya Xia; Zhongkui Li; Hsu-Ping Kuo; Yuanfang Liu; Zheng Li; Qingqing Ding; Su Zhang; Bill Spohn; Yan Yang; Yongkun Wei; Jing-Yu Lang; Douglas B Evans; Paul J Chiao; James L Abbruzzese; Mien-Chie Hung
Targeted expression of BikDD eradicates pancreatic tumors in noninvasive imaging models.
Cancer cell 2007;12(1):52-65.
2007: Julie G Izzo; Usha Malhotra; Tsung-Teh Wu; Rajyalakshmi Luthra; Arlene M Correa; Stephen G Swisher; Wayne L Hofstetter; K.S. Chao; Mien-Chie Hung; Jaffer A Ajani
Clinical biology of esophageal adenocarcinoma after surgery is influenced by nuclear factor-kappaB expression.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2007;16(6):1200-5.
2007: Qingqing Ding; Xianghuo He; Jung-Mao Hsu; Weiya Xia; Chun-Te Chen; Long-Yuan Li; Dung-Fang Lee; Jaw-Ching Liu; qing zhong; Xiaodong Wang; Mien-Chie Hung
Degradation of Mcl-1 by beta-TrCP mediates glycogen synthase kinase 3-induced tumor suppression and chemosensitization.
Molecular and cellular biology 2007;27(11):4006-17.
2007: Qingqing Ding; Xianghuo He; Weiya Xia; Jung-Mao Hsu; Chun-Te Chen; Long-Yuan Li; Dung-Fang Lee; Jer-Yen Yang; Xiaoming Xie; Jaw-Ching Liu; Mien-Chie Hung
Myeloid cell leukemia-1 inversely correlates with glycogen synthase kinase-3beta activity and associates with poor prognosis in human breast cancer.
Cancer research 2007;67(10):4564-71.
2007: Tadashi Uwagawa; Zhongkui Li; Zhe Chang; Qianghua Xia; Bailu Peng; Guido M Sclabas; Satoshi Ishiyama; Mien-Chie Hung; Douglas B Evans; James L Abbruzzese; Paul J Chiao
Mechanisms of synthetic serine protease inhibitor (FUT-175)-mediated cell death.
Cancer 2007;109(10):2142-53.
2007: Mathew C Casimiro; Olga Rodriguez; Llana Pootrakul; Maral Aventian; Nadia Lushina; Caroline Cromelin; Georgina Ferzli; Kevin Johnson; Stanley T Fricke; Fantahun Diba; Bhaskar V S Kallakury; Chioma Ohanyerenwa; Maxine Chen; Michael Ostrowski; Mien-Chie Hung; Shafaat A Rabbani; Ram H. Datar; Richard J Cote; Richard G Pestell; Chris Albanese
ErbB-2 induces the cyclin D1 gene in prostate epithelial cells in vitro and in vivo.
Cancer research 2007;67(9):4364-72.
2007: Huang Wei-Chien; Tsai-Kai Ju; Mien-Chie Hung; Ching-Chow Chen
Phosphorylation of CBP by IKKalpha promotes cell growth by switching the binding preference of CBP from p53 to NF-kappaB.
Molecular cell 2007;26(1):75-87.
2007: Sheng-Chieh Hsu; Mien-Chie Hung
Characterization of a novel tripartite nuclear localization sequence in the EGFR family.
The Journal of biological chemistry 2007;282(14):10432-40.
2007: Julie G Izzo; Rajyalakshmi Luthra; Tsung-Teh Wu; Arlene M Correa; Madan G Luthra; Sharmila Anandasabapathy; K.S. Chao; Mien-Chie Hung; Bharat B Aggarwal; Walter N Hittelman; Jaffer A Ajani
Molecular mechanisms in Barrett's metaplasia and its progression.
Seminars in oncology 2007;34(2 Suppl 1):S2-6.
2007: Jen-Liang Su; C-J Yen; P-S Chen; Shuang-En Chuang; Chih-Chen Hong; I-H Kuo; H-Y Chen; Mien-Chie Hung; Min-Liang Kuo
The role of the VEGF-C/VEGFR-3 axis in cancer progression.
British journal of cancer 2007;96(4):541-5.
2007: Julie G Izzo; Rajyalakshmi Luthra; Jennifer Sims-Mourtada; K.S. Chao; Jeffrey H Lee; Tsung-The Wu; Arlene M Correa; Madan Luthra; Bharat Aggarwal; Mien-Chie Hung; Jaffer A Ajani
Emerging molecular targets in esophageal cancers.
Gastrointestinal cancer research : GCR 2007;1(4 Suppl 2):S3-6.
2007: Yong Liao; Dihua Yu; Mien-Chie Hung
Novel approaches for chemosensitization of breast cancer cells: the E1A story.
Advances in experimental medicine and biology 2007;608():144-69.
2007: Kuang-Lei Tsai; Yuh-Ju Sun; Cheng-Yang Huang; Jer-Yen Yang; Mien-Chie Hung; Chwan-Deng Hsiao
Crystal structure of the human FOXO3a-DBD/DNA complex suggests the effects of post-translational modification.
Nucleic acids research 2007;35(20):6984-94.
2007: Hui Wen Lo; Mien-Chie Hung
Nuclear EGFR signalling network in cancers: linking EGFR pathway to cell cycle progression, nitric oxide pathway and patient survival.
British journal of cancer 2007;96 Suppl():R16-20.
2006: Shao-Chun Wang; Yusuke Nakajima; Yung-Luen Yu; Weiya Xia; Chun-Te Chen; Cheng-Chieh Yang; Eric W McIntush; Long-Yuan Li; David H Hawke; Ryuji Kobayashi; Mien-Chie Hung
Tyrosine phosphorylation controls PCNA function through protein stability.
Nature cell biology 2006;8(12):1359-68.
2006: Hong Jiang; Melissa V Olson; Diana R Medrano; Ok-Hee Lee; Jing Xu; Yuji Piao; Marta M Alonso; Candelaria Gomez-Manzano; Mien-Chie Hung; W K Alfred Yung; Juan Fueyo
A novel CRM1-dependent nuclear export signal in adenoviral E1A protein regulated by phosphorylation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(14):2603-5.
2006: Funda Meric-Bernstam; Mien-Chie Hung
Advances in targeting human epidermal growth factor receptor-2 signaling for cancer therapy.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(21):6326-30.
2006: Bo Ping; Xianghuo He; Weiya Xia; Dung-Fang Lee; Yongkun Wei; Dihua Yu; Gordon Mills; Daren Shi; Mien-Chie Hung
Cytoplasmic expression of p21CIP1/WAF1 is correlated with IKKbeta overexpression in human breast cancers.
International journal of oncology 2006;29(5):1103-10.
2006: Jer-Yen Yang; Cong S Zong; Weiya Xia; Yongkun Wei; Mohamed Ali-Seyed; Zheng Li; Kristine Broglio; Donald A Berry; Mien-Chie Hung
MDM2 promotes cell motility and invasiveness by regulating E-cadherin degradation.
Molecular and cellular biology 2006;26(19):7269-82.
2006: Zhenming Yu; Weiya Xia; Hong-Ying Wang; Shao-Chun Wang; Yong Pan; Ka Yin Kwong; Gabriel N Hortobagyi; Mien-Chie Hung
Antitumor activity of an Ets protein, PEA3, in breast cancer cell lines MDA-MB-361DYT2 and BT474M1.
Molecular carcinogenesis 2006;45(9):667-75.
2006: Hui Wen Lo; Mohamed Ali-Seyed; Yadi Wu; Geoffrey Bartholomeusz; Sheng-Chieh Hsu; Mien-Chie Hung
Nuclear-cytoplasmic transport of EGFR involves receptor endocytosis, importin beta1 and CRM1.
Journal of cellular biochemistry 2006;98(6):1570-83.
2006: Wei-Ya Xia; Huang-Chun Lien; Shao-Chun Wang; Yung Pan; Aysegul Sahin; Yau-Hung Kuo; King-Jen Chang; Xin Zhou; Hongying Wang; Zhengming Yu; Gabriel Hortobagyi; Dar-Ren Shi; Mien-Chie Hung
Expression of PEA3 and lack of correlation between PEA3 and HER-2/neu expression in breast cancer.
Breast cancer research and treatment 2006;98(3):295-301.
2006: Chao-Kai Chou; Jen-Yu Hung; Jaw-Ching Liu; Chun-Te Chen; Mien-Chie Hung
An attenuated Salmonella oral DNA vaccine prevents the growth of hepatocellular carcinoma and colon cancer that express alpha-fetoprotein.
Cancer gene therapy 2006;13(8):746-52.
2006: C-P Day; Kung-Ming Rau; L Qiu; C-W Liu; Hsu-Ping Kuo; Xiaoming Xie; G Lopez-Berestein; Gabriel N Hortobagyi; Mien-Chie Hung
Mutant Bik expression mediated by the enhanced minimal topoisomerase IIalpha promoter selectively suppressed breast tumors in an animal model.
Cancer gene therapy 2006;13(7):706-19.
2006: Zheng Li; Qingqing Ding; Yan Li; Stephanie A Miller; James L Abbruzzese; Mien-Chie Hung
Suppression of pancreatic tumor progression by systemic delivery of a pancreatic-cancer-specific promoter driven Bik mutant.
Cancer letters 2006;236(1):58-63.
2006: Rita Nahta; Dihua Yu; Mien-Chie Hung; Gabriel N Hortobagyi; Francisco J Esteva
Mechanisms of disease: understanding resistance to HER2-targeted therapy in human breast cancer.
Nature clinical practice. Oncology 2006;3(5):269-80.
2006: Jen-Liang Su; Pan-Chyr Yang; Jin-Yuan Shih; Ching-Yao Yang; Lin-Hung Wei; Chang-Yao Hsieh; Chia-Hung Chou; Yung-Ming Jeng; Ming-Yang Wang; King-Jen Chang; Mien-Chie Hung; Min-Liang Kuo
The VEGF-C/Flt-4 axis promotes invasion and metastasis of cancer cells.
Cancer cell 2006;9(3):209-23.
2006: Min Li; Yingqun Wang; Mien-Chie Hung; Perry Kannan
Inefficient proteasomal-degradation pathway stabilizes AP-2alpha and activates HER-2/neu gene in breast cancer.
International journal of cancer. Journal international du cancer 2006;118(4):802-11.
2006: Marina Konopleva; Weiguo Zhang; Yue-Xi Shi; Teresa McQueen; Twee Tsao; Maen Abdelrahim; Mark F Munsell; Mary Johansen; Dihua Yu; Timothy Madden; Stephen H Safe; Mien-Chie Hung; Michael Andreeff
Synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid induces growth arrest in HER2-overexpressing breast cancer cells.
Molecular cancer therapeutics 2006;5(2):317-28.
2006: Geoffrey Bartholomeusz; Yadi Wu; Mohamed Ali-Seyed; Weiya Xia; Ka Yin Kwong; Gabriel Hortobagyi; Mien-Chie Hung
Nuclear translocation of the pro-apoptotic Bcl-2 family member Bok induces apoptosis.
Molecular carcinogenesis 2006;45(2):73-83.
2006: Hui Wen Lo; Sheng-Chieh Hsu; Mien-Chie Hung
EGFR signaling pathway in breast cancers: from traditional signal transduction to direct nuclear translocalization.
Breast cancer research and treatment 2006;95(3):211-8.
2006: Hui Wen Lo; Mien-Chie Hung
Nuclear EGFR signalling network in cancers: linking EGFR pathway to cell cycle progression, nitric oxide pathway and patient survival.
British journal of cancer 2006;94(2):184-8.
2006: I-Fen Chen; Fu Ou-Yang; Jen-Yu Hung; Jaw-Ching Liu; Hongying Wang; Shao-Chun Wang; Ming-Feng Hou; Gabriel N Hortobagyi; Mien-Chie Hung
AIM2 suppresses human breast cancer cell proliferation in vitro and mammary tumor growth in a mouse model.
Molecular cancer therapeutics 2006;5(1):1-7.
2006: Fu Ou-Yang; Keng-Li Lan; Chun-Te Chen; Jaw-Ching Liu; Chu-Li Weng; Chao-Kai Chou; Xiaoming Xie; Jen-Yu Hung; Yongkun Wei; Gabriel N Hortobagyi; Mien-Chie Hung
Endostatin-cytosine deaminase fusion protein suppresses tumor growth by targeting neovascular endothelial cells.
Cancer research 2006;66(1):378-84.
2006: Norihisa Hanada; Hui Wen Lo; Chi-Ping Day; Yong Pan; Yusuke Nakajima; Mien-Chie Hung
Co-regulation of B-Myb expression by E2F1 and EGF receptor.
Molecular carcinogenesis 2006;45(1):10-7.
2005: Mien-Chie Hung; Kenneth Fong; Joseph K-K Li
Asian scientists and the "glass ceiling".
Science (New York, N.Y.) 2005;310(5755):1767-8.
2005: Dipak K Giri; Mohamed Ali-Seyed; Long-Yuan Li; Dung-Fang Lee; Pin Ling; Geoffrey Bartholomeusz; Shao-Chun Wang; Mien-Chie Hung
Endosomal transport of ErbB-2: mechanism for nuclear entry of the cell surface receptor.
Molecular and cellular biology 2005;25(24):11005-18.
2005: Shao-Chun Wang; Mien-Chie Hung
Cytoplasmic/nuclear shuttling and tumor progression.
Annals of the New York Academy of Sciences 2005;1059():11-5.
2005: Kevin R Coombes; Spiridon Tsavachidis; Jeffrey S Morris; Keith A Baggerly; Mien-Chie Hung; Henry M Kuerer
Improved peak detection and quantification of mass spectrometry data acquired from surface-enhanced laser desorption and ionization by denoising spectra with the undecimated discrete wavelet transform.
Proteomics 2005;5(16):4107-17.
2005: Tai-Lung Cha; Binhua P Zhou; Weiya Xia; Yadi Wu; Cheng-Chieh Yang; Chun-Te Chen; Bo Ping; Arie P Otte; Mien-Chie Hung
Akt-mediated phosphorylation of EZH2 suppresses methylation of lysine 27 in histone H3.
Science (New York, N.Y.) 2005;310(5746):306-10.
2005: Kristen Bisanz; Jie Yu; Magnus Edlund; Bill Spohn; Mien-Chie Hung; Leland W K Chung; Chia-Ling Hsieh
Targeting ECM-integrin interaction with liposome-encapsulated small interfering RNAs inhibits the growth of human prostate cancer in a bone xenograft imaging model.
Molecular therapy : the journal of the American Society of Gene Therapy 2005;12(4):634-43.
2005: Chandra Bartholomeusz; Hiroaki Itamochi; Linda X H Yuan; Francisco J Esteva; Christopher G Wood; Naoki Terakawa; Mien-Chie Hung; Naoto T Ueno
Bcl-2 antisense oligonucleotide overcomes resistance to E1A gene therapy in a low HER2-expressing ovarian cancer xenograft model.
Cancer research 2005;65(18):8406-13.
2005: Kung-Ming Rau; H-Y Kang; Tai-Lung Cha; S A Miller; Mien-Chie Hung
The mechanisms and managements of hormone-therapy resistance in breast and prostate cancers.
Endocrine-related cancer 2005;12(3):511-32.
2005: Qingqing Ding; Weiya Xia; Jaw-Ching Liu; Jer-Yen Yang; Dung-Fang Lee; Jiahong Xia; Geoffrey Bartholomeusz; Yan Li; Yong Pan; Zheng Li; Ralf C Bargou; Jun Qin; Chien-Chen Lai; Fuu-Jen Tsai; Chang-Hai Tsai; Mien-Chie Hung
Erk associates with and primes GSK-3beta for its inactivation resulting in upregulation of beta-catenin.
Molecular cell 2005;19(2):159-70.
2005: Hui Wen Lo; Sheng-Chieh Hsu; Mohamed Ali-Seyed; Mehmet Gunduz; Weiya Xia; Yongkun Wei; Geoffrey Bartholomeusz; Jin-Yuan Shih; Mien-Chie Hung
Nuclear interaction of EGFR and STAT3 in the activation of the iNOS/NO pathway.
Cancer cell 2005;7(6):575-89.
2005: Binhua P Zhou; Mien-Chie Hung
Wnt, hedgehog and snail: sister pathways that control by GSK-3beta and beta-Trcp in the regulation of metastasis.
Cell cycle (Georgetown, Tex.) 2005;4(6):772-6.
2005: Mien-Chie Hung
When all colonies are blue.
Cancer biology & therapy 2005;4(5):612-4.
2005: Yan M Li; Binhua P Zhou; Jiong Deng; Yong Pan; Nissim Hay; Mien-Chie Hung
A hypoxia-independent hypoxia-inducible factor-1 activation pathway induced by phosphatidylinositol-3 kinase/Akt in HER2 overexpressing cells.
Cancer research 2005;65(8):3257-63.
2005: Ruping Shao; Dung-Fang Lee; Yong Wen; Yi Ding; Weiya Xia; Bo Ping; Hideo Yagita; Bill Spohn; Mien-Chie Hung
E1A sensitizes cancer cells to TRAIL-induced apoptosis through enhancement of caspase activation.
Molecular cancer research : MCR 2005;3(4):219-26.
2005: Rakesh Kumar; Mien-Chie Hung
Signaling intricacies take center stage in cancer cells.
Cancer research 2005;65(7):2511-5.
2005: Tai-Lung Cha; Lin Qiu; Chun-Te Chen; Yong Wen; Mien-Chie Hung
Emodin down-regulates androgen receptor and inhibits prostate cancer cell growth.
Cancer research 2005;65(6):2287-95.
2005: Jinjiang Dong; Junying Peng; Haixia Zhang; Wallace H Mondesire; Weiguo Jian; Gordon B Mills; Mien-Chie Hung; Funda Meric-Bernstam
Role of glycogen synthase kinase 3beta in rapamycin-mediated cell cycle regulation and chemosensitivity.
Cancer research 2005;65(5):1961-72.
2005: Mickey C-T Hu; Mien-Chie Hung
Role of IkappaB kinase in tumorigenesis.
Future oncology (London, England) 2005;1(1):67-78.
2005: Hui Wen Lo; Chi-Ping Day; Mien-Chie Hung
Cancer-specific gene therapy.
Advances in genetics 2005;54():235-55.
2005: Timothy M Pawlik; Herbert A Fritsche; Kevin R Coombes; Lianchun Xiao; Savitri Krishnamurthy; Kelly K Hunt; Lajos Pusztai; Jeng-Neng Chen; Charlotte H Clarke; Banu Arun; Mien-Chie Hung; Henry M Kuerer
Significant differences in nipple aspirate fluid protein expression between healthy women and those with breast cancer demonstrated by time-of-flight mass spectrometry.
Breast cancer research and treatment 2005;89(2):149-57.
2005: Hui Wen Lo; Weiya Xia; Yongkun Wei; Mohamed Ali-Seyed; Shiu-Feng Huang; Mien-Chie Hung
Novel prognostic value of nuclear epidermal growth factor receptor in breast cancer.
Cancer research 2005;65(1):338-48.
2004: Zheng Li; Chi-Ping Day; Jer-Yen Yang; Wen-Bin Tsai; Guillermina Lozano; Hsiu-Ming Shih; Mien-Chie Hung
Adenoviral E1A targets Mdm4 to stabilize tumor suppressor p53.
Cancer research 2004;64(24):9080-5.
2004: Shao-Chun Wang; Mien-Chie Hung
Finding the bEST routes to cancer.
Cancer biology & therapy 2004;3(11):1090-1.
2004: Yan M Li; Yong Pan; Yongkun Wei; Xiaoyun Cheng; Binhua P Zhou; Ming Tan; Xiaoyan Zhou; Weiya Xia; Gabriel N Hortobagyi; Dihua Yu; Mien-Chie Hung
Upregulation of CXCR4 is essential for HER2-mediated tumor metastasis.
Cancer cell 2004;6(5):459-69.
2004: Henry M Kuerer; Kevin R Coombes; Jeng-Neng Chen; Lianchun Xiao; Charlotte Clarke; Herbert A Fritsche; Savitri Krishnamurthy; Sylvie Marcy; Mien-Chie Hung; Kelly K Hunt
Association between ductal fluid proteomic expression profiles and the presence of lymph node metastases in women with breast cancer.
Surgery 2004;136(5):1061-9.
2004: Jin-Shing Chen; Jaw-Ching Liu; Lei Shen; Kung-Ming Rau; Hsu-Ping Kuo; Yan M Li; Daren Shi; Yung-Chie Lee; King-Jen Chang; Mien-Chie Hung
Cancer-specific activation of the survivin promoter and its potential use in gene therapy.
Cancer gene therapy 2004;11(11):740-7.
2004: Wallace H Mondesire; Weiguo Jian; Haixia Zhang; Joe Ensor; Mien-Chie Hung; Gordon B Mills; Funda Meric-Bernstam
Targeting mammalian target of rapamycin synergistically enhances chemotherapy-induced cytotoxicity in breast cancer cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(20):7031-42.
2004: Binhua P Zhou; Jiong Deng; Weiya Xia; Jihong Xu; Yan M Li; Mehmet Gunduz; Mien-Chie Hung
Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition.
Nature cell biology 2004;6(10):931-40.
2004: Shao-Chun Wang; Huang-Chun Lien; Weiya Xia; I-Fen Chen; Hui Wen Lo; Zhiqin Wang; Mohamed Ali-Seyed; Dung-Fang Lee; Geoffrey Bartholomeusz; Fu Ou-Yang; Dipak K Giri; Mien-Chie Hung
Binding at and transactivation of the COX-2 promoter by nuclear tyrosine kinase receptor ErbB-2.
Cancer cell 2004;6(3):251-61.
2004: Yong Liao; Mien-Chie Hung
A new role of protein phosphatase 2a in adenoviral E1A protein-mediated sensitization to anticancer drug-induced apoptosis in human breast cancer cells.
Cancer research 2004;64(17):5938-42.
2004: Yong Liao; Yiyu Zou; Wei-Ya Xia; Mien-Chie Hung
Enhanced paclitaxel cytotoxicity and prolonged animal survival rate by a nonviral-mediated systemic delivery of E1A gene in orthotopic xenograft human breast cancer.
Cancer gene therapy 2004;11(9):594-602.
2004: Yoichi Nagata; Keng-Hsueh Lan; Xiaoyan Zhou; Ming Tan; Francisco J Esteva; Aysegul A Sahin; Kristine S Klos; Ping Li; Brett P Monia; Nina T Nguyen; Gabriel N Hortobagyi; Mien-Chie Hung; Dihua Yu
PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients.
Cancer cell 2004;6(2):117-27.
2004: Weiya Xia; Jin-Shing Chen; Xian Zhou; Pei-Rong Sun; Dung-Fang Lee; Yong Liao; Binhua P Zhou; Mien-Chie Hung
Phosphorylation/cytoplasmic localization of p21Cip1/WAF1 is associated with HER2/neu overexpression and provides a novel combination predictor for poor prognosis in breast cancer patients.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(11):3815-24.
2004: Rita Nahta; Takeshi Takahashi; Naoto T Ueno; Mien-Chie Hung; Francisco J Esteva
P27(kip1) down-regulation is associated with trastuzumab resistance in breast cancer cells.
Cancer research 2004;64(11):3981-6.
2004: Keishi Makino; Chi-Ping Day; Shao-Chun Wang; Yan M Li; Mien-Chie Hung
Upregulation of IKKalpha/IKKbeta by integrin-linked kinase is required for HER2/neu-induced NF-kappaB antiapoptotic pathway.
Oncogene 2004;23(21):3883-7.
2004: Mickey C-T Hu; Dung-Fang Lee; Weiya Xia; Leonard Golfman; Fu Ou-Yang; Jer-Yen Yang; Yiyu Zou; Shilai Bao; Norihisa Hanada; Hitomi Saso; Ryuji Kobayashi; Mien-Chie Hung
IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a.
Cell 2004;117(2):225-37.
2004: Rita Nahta; Mien-Chie Hung; Francisco J Esteva
The HER-2-targeting antibodies trastuzumab and pertuzumab synergistically inhibit the survival of breast cancer cells.
Cancer research 2004;64(7):2343-6.
2004: Duen-Hwa Yan; Yong Wen; Li-Kuo Su; Weiya Xia; Shao-Chun Wang; Su Zhang; Lin Gan; Dung-Fang Lee; Bill Spohn; Jennifer A Frey; Gabriel N Hortobagyi; Mien-Chie Hung
A delayed chemically induced tumorigenesis in Brca2 mutant mice.
Oncogene 2004;23(10):1896-901.
2004: Christine M Lee; Hui Wen Lo; Ru-Ping Shao; Shao-Chun Wang; Weiya Xia; David M Gershenson; Mien-Chie Hung
Selective activation of ceruloplasmin promoter in ovarian tumors: potential use for gene therapy.
Cancer research 2004;64(5):1788-93.
2004: Jiong Deng; Weiya Xia; Stephanie A Miller; Yong Wen; Hong-Ying Wang; Mien-Chie Hung
Crossregulation of NF-kappaB by the APC/GSK-3beta/beta-catenin pathway.
Molecular carcinogenesis 2004;39(3):139-46.
2004: Woo-Chul Noh; Wallace H Mondesire; Junying Peng; Weiguo Jian; Haixia Zhang; JinJiang Dong; Gordon B Mills; Mien-Chie Hung; Funda Meric-Bernstam
Determinants of rapamycin sensitivity in breast cancer cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(3):1013-23.
2004: Duen-Hwa Yan; Bill Spohn; Mien-Chie Hung
Delivery of DNA to tumor cells using cationic liposomes.
Methods in molecular biology (Clifton, N.J.) 2004;245():125-36.
2004: Melanie Royce; Weiya Xia; Aysegul A Sahin; Hiroshi Katayama; Dennis A Johnston; Gabriel Hortobagyi; Subrata Sen; Mien-Chie Hung
STK15/Aurora-A expression in primary breast tumors is correlated with nuclear grade but not with prognosis.
Cancer 2004;100(1):12-9.
2003: Ashraful Hoque; Jennifer Carter; Weiya Xia; Mien-Chie Hung; Aysegul A Sahin; Subrata Sen; Scott M Lippman
Loss of aurora A/STK15/BTAK overexpression correlates with transition of in situ to invasive ductal carcinoma of the breast.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2003;12(12):1518-22.
2003: Yan M Li; Yong Wen; Binhua P Zhou; Hsu-Ping Kuo; Qingqing Ding; Mien-Chie Hung
Enhancement of Bik antitumor effect by Bik mutants.
Cancer research 2003;63(22):7630-3.
2003: Binhua P Zhou; Mien-Chie Hung
Dysregulation of cellular signaling by HER2/neu in breast cancer.
Seminars in oncology 2003;30(5 Suppl 16):38-48.
2003: Wei-Ping Lee; Dar-In Tai; Sun-Lung Tsai; Chau-Ting Yeh; Yee Chao; Shou-Dong Lee; Mien-Chie Hung
Adenovirus type 5 E1A sensitizes hepatocellular carcinoma cells to gemcitabine.
Cancer research 2003;63(19):6229-36.
2003: Kevin R Coombes; Herbert A Fritsche; Charlotte Clarke; Jeng-Neng Chen; Keith A Baggerly; Jeffrey S Morris; Lian-Chun Xiao; Mien-Chie Hung; Henry M Kuerer
Quality control and peak finding for proteomics data collected from nipple aspirate fluid by surface-enhanced laser desorption and ionization.
Clinical chemistry 2003;49(10):1615-23.
2003: Yong Liao; Mien-Chie Hung
Regulation of the activity of p38 mitogen-activated protein kinase by Akt in cancer and adenoviral protein E1A-mediated sensitization to apoptosis.
Molecular and cellular biology 2003;23(19):6836-48.
2003: Yong Wen; Dipak Giri; Duen-Hwa Yan; Bill Spohn; Ralph G Zinner; Weiya Xia; Timothy C Thompson; Robert J Matusik; Mien-Chie Hung
Prostate-specific antitumor activity by probasin promoter-directed p202 expression.
Molecular carcinogenesis 2003;37(3):130-7.
2003: S Mahmoud A Najafi; Zheng Li; Keishi Makino; Ruping Shao; Mien-Chie Hung
The adenoviral E1A induces p21WAF1/CIP1 expression in cancer cells.
Biochemical and biophysical research communications 2003;305(4):1099-104.
2003: Jin-Shing Chen; Kengli Lan; Mien-Chie Hung
Strategies to target HER2/neu overexpression for cancer therapy.
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2003;6(3):129-36.
2003: Christine M Lee; Hyun S Shvartsman; Michael T Deavers; Shao-Chun Wang; Weiya Xia; Rosemarie Schmandt; Diane C Bodurka; E Neely Atkinson; Anais Malpica; David M Gershenson; Mien-Chie Hung; Karen H Lu
beta-catenin nuclear localization is associated with grade in ovarian serous carcinoma.
Gynecologic oncology 2003;88(3):363-8.
2002: Ka Yin Kwong; Yiyu Zou; Chi-Ping Day; Mien-Chie Hung
The suppression of colon cancer cell growth in nude mice by targeting beta-catenin/TCF pathway.
Oncogene 2002;21(54):8340-6.
2002: Naoto T Ueno; Chandra Bartholomeusz; Weiya Xia; Pervin Anklesaria; Elizabeth M Bruckheimer; Elise Mebel; Ralph Paul; Song Li; George H Yo; Leaf Huang; Mien-Chie Hung
Systemic gene therapy in human xenograft tumor models by liposomal delivery of the E1A gene.
Cancer research 2002;62(22):6712-6.
2002: Zhaohui Feng; Wenwei Hu; James X Chen; Annie Pao; Haiying Li; William N Rom; Mien-Chie Hung; Moon-shong Tang
Preferential DNA damage and poor repair determine ras gene mutational hotspot in human cancer.
Journal of the National Cancer Institute 2002;94(20):1527-36.
2002: Sangkyou Lee; Wentao Yang; Keng-Hsueh Lan; Shankar Sellappan; Kristine S Klos; Gabriel Hortobagyi; Mien-Chie Hung; Dihua Yu
Enhanced sensitization to taxol-induced apoptosis by herceptin pretreatment in ErbB2-overexpressing breast cancer cells.
Cancer research 2002;62(20):5703-10.
2002: Shuyuan Yeh; Meng-Yin Tsai; Qingquan Xu; Xiao-Min Mu; Henry Lardy; Ko-En Huang; Hank Lin; Shauh-Der Yeh; Saleh Altuwaijri; Xinchang Zhou; Lianping Xing; Brendan F Boyce; Mien-Chie Hung; Su Zhang; Lin Gan; Chawnshang Chang; Min-Chi Hung
Generation and characterization of androgen receptor knockout (ARKO) mice: an in vivo model for the study of androgen functions in selective tissues.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(21):13498-503.
2002: Jiong Deng; Stephanie A Miller; Hong-Ying Wang; Weiya Xia; Yong Wen; Binhua P Zhou; Yan Li; Shiaw-Yih Lin; Mien-Chie Hung
beta-catenin interacts with and inhibits NF-kappa B in human colon and breast cancer.
Cancer cell 2002;2(4):323-34.
2002: Yi Ding; Yong Wen; Bill Spohn; Li Wang; Weiya Xia; Ka Yin Kwong; Ruping Shao; Zheng Li; Gabriel N Hortobagyi; Mien-Chie Hung; Duen-Hwa Yan
Proapoptotic and antitumor activities of adenovirus-mediated p202 gene transfer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(10):3290-7.
2002: Shinichi Asada; Yongmun Choi; Masaki Yamada; Shao-Chun Wang; Mien-Chie Hung; Jun Qin; Motonari Uesugi
External control of Her2 expression and cancer cell growth by targeting a Ras-linked coactivator.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(20):12747-52.
2002: Stephan A Vorburger; Abujiang Pataer; Kazumi Yoshida; Glen N Barber; Weiya Xia; Paul J Chiao; Lee M Ellis; Mien-Chie Hung; Stephen G Swisher; Kelly K Hunt
Role for the double-stranded RNA activated protein kinase PKR in E2F-1-induced apoptosis.
Oncogene 2002;21(41):6278-88.
2002: Ana M Tari; Soo-Jeong Lim; Mien-Chie Hung; Francisco J Esteva; Gabriel Lopez-Berestein
Her2/neu induces all-trans retinoic acid (ATRA) resistance in breast cancer cells.
Oncogene 2002;21(34):5224-32.
2002: Douglas B Villaret; Bonnie Glisson; Daniel Kenady; Ehab Hanna; Mary Carey; Lyon L Gleich; George H Yoo; Neal D Futran; Mien-Chie Hung; Pervin Anklesaria; Alison E Heald
A multicenter phase II study of tgDCC-E1A for the intratumoral treatment of patients with recurrent head and neck squamous cell carcinoma.
Head & neck 2002;24(7):661-9.
2002: Binhua P Zhou; Mien-Chie Hung
Novel targets of Akt, p21(Cipl/WAF1), and MDM2.
Seminars in oncology 2002;29(3 Suppl 11):62-70.
2002: Ming Tan; Tong Jing; Keng-Hsueh Lan; Christopher L Neal; Ping Li; Sangkyou Lee; Dexing Fang; Yoichi Nagata; Jiaxin Liu; Ralph B Arlinghaus; Mien-Chie Hung; Dihua Yu
Phosphorylation on tyrosine-15 of p34(Cdc2) by ErbB2 inhibits p34(Cdc2) activation and is involved in resistance to taxol-induced apoptosis.
Molecular cell 2002;9(5):993-1004.
2002: Zhaohui Feng; Wenwei Hu; Elena Komissarova; Annie Pao; Mien-Chie Hung; Gerald M Adair; Moon-shong Tang
Transcription-coupled DNA repair is genomic context-dependent.
The Journal of biological chemistry 2002;277(15):12777-83.
2002: Funda Meric; Mien-Chie Hung; Gabriel N Hortobagyi; Kelly K Hunt
HER2/neu in the management of invasive breast cancer.
Journal of the American College of Surgeons 2002;194(4):488-501.
2002: Shao-Chun Wang; Ruping Shao; Annie Y Pao; Su Zhang; Mien-Chie Hung; Li-Kuo Su
Inhibition of cancer cell growth by BRCA2.
Cancer research 2002;62(5):1311-4.
2002: Massimo Cristofanilli; Giovanni De Gasperis; Lisha Zhang; Mien-Chie Hung; Peter R C Gascoyne; Gabriel N Hortobagyi
Automated electrorotation to reveal dielectric variations related to HER-2/neu overexpression in MCF-7 sublines.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(2):615-9.
2002: Funda Meric; Wei-Ping Lee; Aysegul Sahin; Haixia Zhang; Hsing-Jien Kung; Mien-Chie Hung
Expression profile of tyrosine kinases in breast cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(2):361-7.
2002: Wei-Ping Lee; Yong Wen; Brian Varnum; Mien-Chie Hung
Akt is required for Axl-Gas6 signaling to protect cells from E1A-mediated apoptosis.
Oncogene 2002;21(3):329-36.
2002: Jiong Deng; Freke Kloosterbooer; Weiya Xia; Mien-Chie Hung
The NH(2)-terminal and conserved region 2 domains of adenovirus E1A mediate two distinct mechanisms of tumor suppression.
Cancer research 2002;62(2):346-50.
2002: Jiong Deng; Haifan Zhang; Freke Kloosterboer; Yong Liao; Jim Klostergaard; Mark L Levitt; Mien-Chie Hung
Ceramide does not act as a general second messenger for ultraviolet-induced apoptosis.
Oncogene 2002;21(1):44-52.
2002: Binhua P Zhou; Yan Li; Mien-Chie Hung
HER-2/Neu signaling and therapeutic approaches in breast cancer.
Breast disease 2002;15():13-24.
2002: Yiyu Zou; Hua Peng; Binhua Zhou; Yong Wen; Shao-Chun Wang; Eing-Mei Tsai; Mien-Chie Hung
Systemic tumor suppression by the proapoptotic gene bik.
Cancer research 2002;62(1):8-12.
2001: S C Wang; Lidong Zhang; Gabriel N Hortobagyi; Mien-Chie Hung
Targeting HER2: recent developments and future directions for breast cancer patients.
Seminars in oncology 2001;28(6 Suppl 18):21-9.
2001: Binhua P Zhou; Y Liao; Weiya Xia; Yiyu Zou; Bill Spohn; Mien-Chie Hung
HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation.
Nature cell biology 2001;3(11):973-82.
2001: Shao-Chun Wang; Keishi Makino; Weiya Xia; J S Kim; S A Im; Hua Peng; S C Mok; S E Singletary; Mien-Chie Hung
DOC-2/hDab-2 inhibits ILK activity and induces anoikis in breast cancer cells through an Akt-independent pathway.
Oncogene 2001;20(47):6960-4.
2001: Ruping Shao; Eing-Mei Tsai; K Wei; R von Lindern; Y H Chen; Keishi Makino; Mien-Chie Hung
E1A inhibition of radiation-induced NF-kappaB activity through suppression of IKK activity and IkappaB degradation, independent of Akt activation.
Cancer research 2001;61(20):7413-6.
2001: S C Wang; Mien-Chie Hung
HER2 overexpression and cancer targeting.
Seminars in oncology 2001;28(5 Suppl 16):115-24.
2001: Yong Wen; Duen-Hwa Yan; B Wang; Bill Spohn; Yi Ding; Ruping Shao; Yiyu Zou; Keping Xie; Mien-Chie Hung
p202, an interferon-inducible protein, mediates multiple antitumor activities in human pancreatic cancer xenograft models.
Cancer research 2001;61(19):7142-7.
2001: Shiaw-Yih Lin; K Makino; Weiya Xia; A Matin; Yong Wen; Ka Yin Kwong; Lilly Bouguignon; Mien-Chie Hung
Nuclear localization of EGF receptor and its potential new role as a transcription factor.
Nature cell biology 2001;3(9):802-8.
2001: Gabriel N Hortobagyi; Naoto T Ueno; Weiya Xia; S Zhang; Judith K Wolf; Joe B Putnam; P L Weiden; Jie S Willey; M Carey; D L Branham; J Y Payne; SD Tucker; Chandra Bartholomeusz; RG Kilbourn; Robert L De Jager; Nour Sneige; Ruth Katz; Pervin Anklesaria; Nuhad K Ibrahim; James L Murray; Richard L Theriault; Vicente Valero; David M Gershenson; M W Bevers; Leaf Huang; Gabriel Lopez-Berestein; Mien-Chie Hung
Cationic liposome-mediated E1A gene transfer to human breast and ovarian cancer cells and its biologic effects: a phase I clinical trial.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2001;19(14):3422-33.
2001: Heng-Yin Yang; Ruping Shao; Mien-Chie Hung; Mong-Hong Lee
p27 Kip1 inhibits HER2/neu-mediated cell growth and tumorigenesis.
Oncogene 2001;20(28):3695-702.
2001: Keishi Makino; Dihua Yu; Mien-Chie Hung
Transcriptional upregulation and activation of p55Cdc via p34(cdc2) in Taxol-induced apoptosis.
Oncogene 2001;20(20):2537-43.
2001: Zhichao Zhou; Shu-Fang Jia; Mien-Chie Hung; Eugenie S Kleinerman
E1A sensitizes HER2/neu-overexpressing Ewing's sarcoma cells to topoisomerase II-targeting anticancer drugs.
Cancer research 2001;61(8):3394-8.
2001: Shao-Chun Wang; Keishi Makino; Li-Kuo Su; A Y Pao; Jang-Seong Kim; Mien-Chie Hung
Ultraviolet irradiation induces BRCA2 protein depletion through a p53-independent and protein synthesis-dependent pathway.
Cancer research 2001;61(7):2838-42.
2001: Lisa A Newman; Weiya Xia; Heng-Yin Yang; Aysegul Sahin; Melissa L Bondy; Farzana Lukmanji; Mien-Chie Hung; Mong-Hong Lee
Correlation of p27 protein expression with HER-2/neu expression in breast cancer.
Molecular carcinogenesis 2001;30(3):169-75.
2001: Binhua P Zhou; Y Liao; Weiya Xia; Bill Spohn; M H Lee; Mien-Chie Hung
Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells.
Nature cell biology 2001;3(3):245-52.
2001: Yiyu Zou; Qing-Ping Wu; W Tansey; Diana Chow; Mien-Chie Hung; Chusilp Charnsangavej; Sidney Wallace; Chun Li
Effectiveness of water soluble poly(L-glutamic acid)-camptothecin conjugate against resistant human lung cancer xenografted in nude mice.
International journal of oncology 2001;18(2):331-6.
2001: Mien-Chie Hung; Duen-Hwa Yan; S Zhang
E1A-Mediated Gene Therapy.
Methods in molecular medicine 2001;39():775-82.
2001: Naoto T Ueno; Dihua Yu; Mien-Chie Hung
E1A: tumor suppressor or oncogene? Preclinical and clinical investigations of E1A gene therapy.
Breast cancer (Tokyo, Japan) 2001;8(4):285-93.
2000: Yong Wen; Mickey C-T Hu; Keishi Makino; Bill Spohn; Geoffrey Bartholomeusz; Duen-Hwa Yan; Mien-Chie Hung
HER-2/neu promotes androgen-independent survival and growth of prostate cancer cells through the Akt pathway.
Cancer research 2000;60(24):6841-5.
2000: Soo-Jeong Lim; Gabriel Lopez-Berestein; Mien-Chie Hung; R Lupu; Ana M Tari
Grb2 downregulation leads to Akt inactivation in heregulin-stimulated and ErbB2-overexpressing breast cancer cells.
Oncogene 2000;19(54):6271-6.
2000: Dihua Yu; Mien-Chie Hung
Overexpression of ErbB2 in cancer and ErbB2-targeting strategies.
Oncogene 2000;19(53):6115-21.
2000: Ratna K Vadlamudi; Liana Adam; Rui-An Wang; Mahitosh Mandal; Diep Nguyen; Aysegul Sahin; Jonathan Chernoff; Mien-Chie Hung; Rakesh Kumar
Regulatable expression of p21-activated kinase-1 promotes anchorage-independent growth and abnormal organization of mitotic spindles in human epithelial breast cancer cells.
The Journal of biological chemistry 2000;275(46):36238-44.
2000: Funda Meric; Yong Liao; Wei-Ping Lee; Raphael E Pollock; Mien-Chie Hung
Adenovirus 5 early region 1A does not induce expression of the ewing sarcoma fusion product EWS-FLI1 in breast and ovarian cancer cell lines.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(10):3832-6.
2000: F Xu; Weiya Xia; Robert Z Luo; Hua Peng; S Zhao; J Dai; Y Long; L Zou; W Le; Jinsong Liu; A F Parlow; Mien-Chie Hung; Robert C Bast; Yinhua Yu
The human ARHI tumor suppressor gene inhibits lactation and growth in transgenic mice.
Cancer research 2000;60(17):4913-20.
2000: Heng-Yin Yang; Binhua P Zhou; Mien-Chie Hung; Mong-Hong Lee
Oncogenic signals of HER-2/neu in regulating the stability of the cyclin-dependent kinase inhibitor p27.
The Journal of biological chemistry 2000;275(32):24735-9.
2000: S Yin; Mien-Chie Hung; DW Goodrich
Adenovirus-mediated N5 gene transfer inhibits tumor cell proliferation by induction of apoptosis.
Cancer gene therapy 2000;7(7):985-90.
2000: Dihua Yu; Mien-Chie Hung
Role of erbB2 in breast cancer chemosensitivity.
BioEssays : news and reviews in molecular, cellular and developmental biology 2000;22(7):673-80.
2000: Ruping Shao; Weiya Xia; Mien-Chie Hung
Inhibition of angiogenesis and induction of apoptosis are involved in E1A-mediated bystander effect and tumor suppression.
Cancer research 2000;60(12):3123-6.
2000: Weiya Xia; Yiu-Keung Lau; Mickey C-T Hu; Li Li; Dennis A Johnston; Shijie Sheng; Adel El-Naggar; Mien-Chie Hung
High tumoral maspin expression is associated with improved survival of patients with oral squamous cell carcinoma.
Oncogene 2000;19(20):2398-403.
2000: Shiaw-Yih Lin; Weiya Xia; Jean C Y Wang; Ka Yin Kwong; Bill Spohn; Yong Wen; Richard G Pestell; Mien-Chie Hung
Beta-catenin, a novel prognostic marker for breast cancer: its roles in cyclin D1 expression and cancer progression.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(8):4262-6.
2000: Binhua P Zhou; Mickey C-T Hu; Stephanie A Miller; Z Yu; Weiya Xia; Shiaw-Yih Lin; Mien-Chie Hung
HER-2/neu blocks tumor necrosis factor-induced apoptosis via the Akt/NF-kappaB pathway.
The Journal of biological chemistry 2000;275(11):8027-31.
2000: X Xing; Shao-Chun Wang; Weiya Xia; Yiyu Zou; Ruping Shao; Ka Yin Kwong; Z Yu; S Zhang; S Miller; L Huang; Mien-Chie Hung
The ets protein PEA3 suppresses HER-2/neu overexpression and inhibits tumorigenesis.
Nature medicine 2000;6(2):189-95.
2000: Mien-Chie Hung; S C Wang
Suppressing HER2/neu-mediated cell transformation by transcriptional repressors.
Breast disease 2000;11():133-44.
2000: Mien-Chie Hung; Gabriel N Hortobagyi; Naoto T Ueno
Development of clinical trial of E1A gene therapy targeting HER-2/neu-overexpressing breast and ovarian cancer.
Advances in experimental medicine and biology 2000;465():171-80.
2000: Naoto T Ueno; Chandra Bartholomeusz; JL Herrmann; Zeev Estrov; Ruping Shao; Michael Andreeff; J Price; R W Paul; Pervin Anklesaria; Dihua Yu; Mien-Chie Hung
E1A-mediated paclitaxel sensitization in HER-2/neu-overexpressing ovarian cancer SKOV3.ip1 through apoptosis involving the caspase-3 pathway.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(1):250-9.
2000: Yong Wen; Duen-Hwa Yan; Bill Spohn; Jiong Deng; Shiaw-Yih Lin; Mien-Chie Hung
Tumor suppression and sensitization to tumor necrosis factor alpha-induced apoptosis by an interferon-inducible protein, p202, in breast cancer cells.
Cancer research 2000;60(1):42-6.
1999: Weiya Xia; Yiu-Keung Lau; Hua-Zhong Zhang; F Y Xiao; Dennis A Johnston; A R Liu; Li Li; Ruth Katz; Mien-Chie Hung
Combination of EGFR, HER-2/neu, and HER-3 is a stronger predictor for the outcome of oral squamous cell carcinoma than any individual family members.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(12):4164-74.
1999: Wei-Ping Lee; Yong Liao; D Robinson; Hsing-Jien Kung; Edison Liu; Mien-Chie Hung
Axl-gas6 interaction counteracts E1A-mediated cell growth suppression and proapoptotic activity.
Molecular and cellular biology 1999;19(12):8075-82.
1999: Lajos Pusztai; F J Esteva; M Cristofanilli; Mien-Chie Hung; Gabriel N Hortobagyi
Chemo-signal therapy, an emerging new approach to modify drug resistance in breast cancer.
Cancer treatment reviews 1999;25(5):271-7.
1999: Mien-Chie Hung; Yiu-Keung Lau
Basic science of HER-2/neu: a review.
Seminars in oncology 1999;26(4 Suppl 12):51-9.
1999: Gabriel N Hortobagyi; Mien-Chie Hung; Aman U Buzdar
Recent developments in breast cancer therapy.
Seminars in oncology 1999;26(4 Suppl 12):11-20.
1999: Ruping Shao; Mickey C-T Hu; Binhua P Zhou; Shiaw-Yih Lin; Paul J Chiao; R H von Lindern; Bill Spohn; Mien-Chie Hung
E1A sensitizes cells to tumor necrosis factor-induced apoptosis through inhibition of IkappaB kinases and nuclear factor kappaB activities.
The Journal of biological chemistry 1999;274(31):21495-8.
1999: Ruey-Long Hong; W H Spohn; Mien-Chie Hung
Curcumin inhibits tyrosine kinase activity of p185neu and also depletes p185neu.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(7):1884-91.
1999: K Li; Ruping Shao; Mien-Chie Hung
Collagen-homology domain 1 deletion mutant of Shc suppresses transformation mediated by neu through a MAPK-independent pathway.
Oncogene 1999;18(16):2617-26.
1999: Naoto T Ueno; Weiya Xia; SD Tucker; S Zhang; Gabriel Lopez-Berestein; Leaf Huang; Mien-Chie Hung
Issues in the development of gene therapy: preclinical experiments in E1A gene delivery.
Oncology reports 1999;6(2):257-62.
1999: Ana M Tari; Mien-Chie Hung; K Li; Gabriel Lopez-Berestein
Growth inhibition of breast cancer cells by Grb2 downregulation is correlated with inactivation of mitogen-activated protein kinase in EGFR, but not in ErbB2, cells.
Oncogene 1999;18(6):1325-32.
1999: Lisha Zhang; Yiu-Keung Lau; Weiya Xia; Gabriel N Hortobagyi; Mien-Chie Hung
Tyrosine kinase inhibitor emodin suppresses growth of HER-2/neu-overexpressing breast cancer cells in athymic mice and sensitizes these cells to the inhibitory effect of paclitaxel.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(2):343-53.
1999: Duen-Hwa Yan; Yong Wen; Bill Spohn; D Choubey; Jordan U Gutterman; Mien-Chie Hung
Reduced growth rate and transformation phenotype of the prostate cancer cells by an interferon-inducible protein, p202.
Oncogene 1999;18(3):807-11.
1998: Li-Kuo Su; Shao-Chun Wang; Y Qi; Weiping Luo; Mien-Chie Hung; Sue-Hwa Lin
Characterization of BRCA2: temperature sensitivity of detection and cell-cycle regulated expression.
Oncogene 1998;17(18):2377-81.
1998: X Xing; S Zhang; J Y Chang; S D Tucker; H Chen; Leaf Huang; Mien-Chie Hung
Safety study and characterization of E1A-liposome complex gene-delivery protocol in an ovarian cancer model.
Gene therapy 1998;5(11):1538-44.
1998: Dihua Yu; Tong Jing; Bolin Liu; J Yao; Ming Tan; Timothy J McDonnell; Mien-Chie Hung
Overexpression of ErbB2 blocks Taxol-induced apoptosis by upregulation of p21Cip1, which inhibits p34Cdc2 kinase.
Molecular cell 1998;2(5):581-91.
1998: Jiong Deng; Weiya Xia; Mien-Chie Hung
Adenovirus 5 E1A-mediated tumor suppression associated with E1A-mediated apoptosis in vivo.
Oncogene 1998;17(17):2167-75.
1998: Ka Yin Kwong; Mien-Chie Hung
A novel splice variant of HER2 with increased transformation activity.
Molecular carcinogenesis 1998;23(2):62-8.
1998: Gabriel N Hortobagyi; Mien-Chie Hung; Gabriel Lopez-Berestein
A Phase I multicenter study of E1A gene therapy for patients with metastatic breast cancer and epithelial ovarian cancer that overexpresses HER-2/neu or epithelial ovarian cancer.
Human gene therapy 1998;9(12):1775-98.
1998: Lisha Zhang; Yiu-Keung Lau; L Xi; R L Hong; D S Kim; C F Chen; Gabriel N Hortobagyi; C Chang; Mien-Chie Hung
Tyrosine kinase inhibitors, emodin and its derivative repress HER-2/neu-induced cellular transformation and metastasis-associated properties.
Oncogene 1998;16(22):2855-63.
1998: Dihua Yu; Mien-Chie Hung
The erbB2 gene as a cancer therapeutic target and the tumor- and metastasis-suppressing function of E1A.
Cancer metastasis reviews 1998;17(2):195-202.
1998: Dihua Yu; Bolin Liu; Tong Jing; D Sun; Janet E Price; S E Singletary; N Ibrahim; Gabriel N Hortobagyi; Mien-Chie Hung
Overexpression of both p185c-erbB2 and p170mdr-1 renders breast cancer cells highly resistant to taxol.
Oncogene 1998;16(16):2087-94.
1998: Xiao-Feng Le; Sadeq Vallian Borujeni; ZM Mu; Mien-Chie Hung; Kun-Sang Chang
Recombinant PML adenovirus suppresses growth and tumorigenicity of human breast cancer cells by inducing G1 cell cycle arrest and apoptosis.
Oncogene 1998;16(14):1839-49.
1997: Ruping Shao; D Karunagaran; Binhua P Zhou; K Li; S S Lo; Jiong Deng; Paul J Chiao; Mien-Chie Hung
Inhibition of nuclear factor-kappaB activity is involved in E1A-mediated sensitization of radiation-induced apoptosis.
The Journal of biological chemistry 1997;272(52):32739-42.
1997: N Kiyokawa; D Karunagaran; E K Lee; Youming Xie; Duen-Hwa Yan; Mien-Chie Hung
Involvement of cdc2-mediated phosphorylation in the cell cycle-dependent regulation of p185neu.
Oncogene 1997;15(22):2633-41.
1997: KR Brader; Judith K Wolf; Mien-Chie Hung; Dihua Yu; Marta Crispens; Kenneth L van Golen; Janet E Price
Adenovirus E1A expression enhances the sensitivity of an ovarian cancer cell line to multiple cytotoxic agents through an apoptotic mechanism.
Clinical cancer research : an official journal of the American Association for Cancer Research 1997;3(11):2017-24.
1997: Kelly K Hunt; Jiong Deng; Ta-Jen Liu; M Wilson-Heiner; Stephen G Swisher; Gary L Clayman; Mien-Chie Hung
Adenovirus-mediated overexpression of the transcription factor E2F-1 induces apoptosis in human breast and ovarian carcinoma cell lines and does not require p53.
Cancer research 1997;57(21):4722-6.
1997: B Liu; D Sun; W Xia; Mien-Chie Hung; D Yu
Cross-reactivity of C219 anti-p170(mdr-1) antibody with p185(c-erbB2) in breast cancer cells: cautions on evaluating p170(mdr-1)
Journal of the National Cancer Institute 1997;89(20):1524-9.
1997: Naoto T Ueno; Dihua Yu; Mien-Chie Hung
Chemosensitization of HER-2/neu-overexpressing human breast cancer cells to paclitaxel (Taxol) by adenovirus type 5 E1A.
Oncogene 1997;15(8):953-60.
1997: N Kiyokawa; E K Lee; D Karunagaran; Shiaw-Yih Lin; Mien-Chie Hung
Mitosis-specific negative regulation of epidermal growth factor receptor, triggered by a decrease in ligand binding and dimerization, can be overcome by overexpression of receptor.
The Journal of biological chemistry 1997;272(30):18656-65.
1997: Shao-Chun Wang; Sue-Hwa Lin; Li-Kuo Su; Mien-Chie Hung
Changes in BRCA2 expression during progression of the cell cycle.
Biochemical and biophysical research communications 1997;234(1):247-51.
1997: H Chen; Dihua Yu; G Chinnadurai; D Karunagaran; Mien-Chie Hung
Mapping of adenovirus 5 E1A domains responsible for suppression of neu-mediated transformation via transcriptional repression of neu.
Oncogene 1997;14(16):1965-71.
1997: Weiping Luo; Christopher G Wood; Karen Earley; Mien-Chie Hung; Sue-Hwa Lin
Suppression of tumorigenicity of breast cancer cells by an epithelial cell adhesion molecule (C-CAM1): the adhesion and growth suppression are mediated by different domains.
Oncogene 1997;14(14):1697-704.
1997: H Chen; Mien-Chie Hung
Involvement of co-activator p300 in the transcriptional regulation of the HER-2/neu gene.
The Journal of biological chemistry 1997;272(10):6101-4.
1997: X Xing; V Liu; Weiya Xia; L Clifton Stephens; Leaf Huang; Gabriel Lopez-Berestein; Mien-Chie Hung
Safety studies of the intraperitoneal injection of E1A--liposome complex in mice.
Gene therapy 1997;4(3):238-43.
1997: J Y Chang; Weiya Xia; Ruping Shao; F Sorgi; Gabriel N Hortobagyi; Leaf Huang; Mien-Chie Hung
The tumor suppression activity of E1A in HER-2/neu-overexpressing breast cancer.
Oncogene 1997;14(5):561-8.
1997: Weiya Xia; Yiu-Keung Lau; Hua-Zhong Zhang; A R Liu; Li Li; N Kiyokawa; Gary L Clayman; Ruth Katz; Mien-Chie Hung
Strong correlation between c-erbB-2 overexpression and overall survival of patients with oral squamous cell carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 1997;3(1):3-9.
1996: J Y Chang; Weiya Xia; Ruping Shao; Mien-Chie Hung
Inhibition of intratracheal lung cancer development by systemic delivery of E1A.
Oncogene 1996;13(7):1405-12.
1996: Dihua Yu; B Liu; M Tan; J Li; S S Wang; Mien-Chie Hung
Overexpression of c-erbB-2/neu in breast cancer cells confers increased resistance to Taxol via mdr-1-independent mechanisms.
Oncogene 1996;13(6):1359-65.
1996: S J Miller; X Xing; L Xi; Mien-Chie Hung
Identification of a specific DNA region required for enhanced transcription of HER2/neu in the MDA-MB453 breast cancer cell line.
DNA and cell biology 1996;15(9):749-57.
1996: X Xing; A Matin; Dihua Yu; Weiya Xia; F Sorgi; Leaf Huang; Mien-Chie Hung
Mutant SV40 large T antigen as a therapeutic agent for HER-2/neu-overexpressing ovarian cancer.
Cancer gene therapy 1996;3(3):168-74.
1996: Youming Xie; Mien-Chie Hung
p66Shc isoform down-regulated and not required for HER-2/neu signaling pathway in human breast cancer cell lines with HER-2/neu overexpression.
Biochemical and biophysical research communications 1996;221(1):140-5.
1996: Lianglin Zhang; Mien-Chie Hung
Sensitization of HER-2/neu-overexpressing non-small cell lung cancer cells to chemotherapeutic drugs by tyrosine kinase inhibitor emodin.
Oncogene 1996;12(3):571-6.
1995: Youming Xie; A M Pendergast; Mien-Chie Hung
Dominant-negative mutants of Grb2 induced reversal of the transformed phenotypes caused by the point mutation-activated rat HER-2/Neu.
The Journal of biological chemistry 1995;270(51):30717-24.
1995: R N Beckhardt; N Kiyokawa; L Xi; Ta-Jen Liu; Mien-Chie Hung; Adel K El-Naggar; Hua-Zhong Zhang; Gary L Clayman
HER-2/neu oncogene characterization in head and neck squamous cell carcinoma.
Archives of otolaryngology--head & neck surgery 1995;121(11):1265-70.
1995: Dihua Yu; A Matin; Weiya Xia; F Sorgi; Leaf Huang; Mien-Chie Hung
Liposome-mediated in vivo E1A gene transfer suppressed dissemination of ovarian cancer cells that overexpress HER-2/neu.
Oncogene 1995;11(7):1383-8.
1995: P Tang; Mien-Chie Hung; Jim Klostergaard
ADP-ribosylation inhibitors inhibit cellular RNA synthesis but do not affect expression of manganous superoxide dismutase or heat shock protein 70 in tumor necrosis factor alpha-sensitive and -resistant tumor cells.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1995;15(9):791-7.
1995: Lianglin Zhang; C J Chang; S S Bacus; Mien-Chie Hung
Suppressed transformation and induced differentiation of HER-2/neu-overexpressing breast cancer cells by emodin.
Cancer research 1995;55(17):3890-6.
1995: R Gum; S W Wang; E Lengyel; Dihua Yu; Mien-Chie Hung; J Juarez; D Boyd
Up-regulation of urokinase-type plasminogen activator expression by the HER2/neu proto-oncogene.
Anticancer research 1995;15(4):1167-72.
1995: Youming Xie; K Li; Mien-Chie Hung
Tyrosine phosphorylation of Shc proteins and formation of Shc/Grb2 complex correlate to the transformation of NIH3T3 cells mediated by the point-mutation activated neu.
Oncogene 1995;10(12):2409-13.
1995: Mien-Chie Hung; A Matin; Y Zhang; X Xing; F Sorgi; Leaf Huang; Dihua Yu
HER-2/neu-targeting gene therapy--a review.
Gene 1995;159(1):65-71.
1995: Y Zhang; Dihua Yu; Weiya Xia; Mien-Chie Hung
HER-2/neu-targeting cancer therapy via adenovirus-mediated E1A delivery in an animal model.
Oncogene 1995;10(10):1947-54.
1995: N Kiyokawa; Duen-Hwa Yan; M E Brown; Mien-Chie Hung
Cell cycle-dependent regulation of p185neu: a relationship between disruption of this regulation and transformation.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(4):1092-6.
1994: Youming Xie; Mien-Chie Hung
Nuclear localization of p185neu tyrosine kinase and its association with transcriptional transactivation.
Biochemical and biophysical research communications 1994;203(3):1589-98.
1994: Dihua Yu; S S Wang; K M Dulski; C M Tsai; Garth L Nicolson; Mien-Chie Hung
c-erbB-2/neu overexpression enhances metastatic potential of human lung cancer cells by induction of metastasis-associated properties.
Cancer research 1994;54(12):3260-6.
1994: A Matin; Mien-Chie Hung
The retinoblastoma gene product, Rb, represses neu expression through two regions within the neu regulatory sequence.
Oncogene 1994;9(5):1333-9.
1994: Dihua Yu; A Matin; Philip W Hinds; Mien-Chie Hung
Transcriptional regulation of neu by RB and E1A in rat-1 cells.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1994;5(4):431-8.
1994: P Tang; Mien-Chie Hung; Jim Klostergaard
TNF cytotoxicity: effects of HER-2/neu expression and inhibitors of ADP-ribosylation.
Lymphokine and cytokine research 1994;13(2):117-23.
1993: A Matin; Mien-Chie Hung
Negative regulation of the neu promoter by the SV40 large T antigen.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1993;4(12):1051-6.
1993: Dihua Yu; D Shi; M Scanlon; Mien-Chie Hung
Reexpression of neu-encoded oncoprotein counteracts the tumor-suppressing but not the metastasis-suppressing function of E1A.
Cancer research 1993;53(23):5784-90.
1993: D B Reardon; Mien-Chie Hung
Downstream signal transduction defects that suppress transformation in two revertant cell lines expressing activated rat neu oncogene.
The Journal of biological chemistry 1993;268(24):18136-42.
1993: Toshihiko Utsumi; A Levitan; Mien-Chie Hung; Jim Klostergaard
Effects of truncation of human pro-tumor necrosis factor transmembrane domain on cellular targeting.
The Journal of biological chemistry 1993;268(13):9511-6.
1993: Nicholas J Donato; Duen-Hwa Yan; Mien-Chie Hung; Michael G Rosenblum
Epidermal growth factor receptor expression and function control cytotoxic responsiveness to tumor necrosis factor in ME-180 squamous carcinoma cells.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1993;4(5):411-9.
1993: Dihua Yu; Judith K Wolf; M Scanlon; Janet E Price; Mien-Chie Hung
Enhanced c-erbB-2/neu expression in human ovarian cancer cells correlates with more severe malignancy that can be suppressed by E1A.
Cancer research 1993;53(4):891-8.
1993: A Matin; Mien-Chie Hung
Repression of neu-induced clonogenicity by dimethylsulfoxide correlates with decreased levels of neu-encoded cell-surface p185 and changes in phosphotyrosine content of endogenous proteins.
Cancer letters 1993;68(1):55-60.
1993: Duen-Hwa Yan; Mien-Chie Hung
Differential activity of the RVF enhancer element in the decreased expression of the neu oncogene in NR-6 cells versus parental Swiss Webster 3T3 cells.
Molecular carcinogenesis 1993;7(1):44-9.
1992: K S Russell; Mien-Chie Hung
Transcriptional repression of the neu protooncogene by estrogen stimulated estrogen receptor.
Cancer research 1992;52(23):6624-9.
1992: Dihua Yu; J Hamada; H Zhang; Garth L Nicolson; Mien-Chie Hung
Mechanisms of c-erbB2/neu oncogene-induced metastasis and repression of metastatic properties by adenovirus 5 E1A gene products.
Oncogene 1992;7(11):2263-70.
1992: Duen-Hwa Yan; M C Marin; Mien-Chie Hung
Differential expression of the neu oncogene in mouse liver and pancreatic cell lines.
Biochemical and biophysical research communications 1992;186(1):363-70.
1992: X Y Zhao; Mien-Chie Hung
Negative autoregulation of the neu gene is mediated by a novel enhancer.
Molecular and cellular biology 1992;12(6):2739-48.
1992: Dihua Yu; A Matin; Mien-Chie Hung
The retinoblastoma gene product suppresses neu oncogene-induced transformation via transcriptional repression of neu.
The Journal of biological chemistry 1992;267(15):10203-6.
1992: M R White; Mien-Chie Hung
Cloning and characterization of the mouse neu promoter.
Oncogene 1992;7(4):677-83.
1992: J C Chan; M Scanlon; H Z Zhang; L B Jia; D H Yu; Mien-Chie Hung; M French; E M Eastman
Molecular cloning and characterization of v-mos-activated transformation-associated proteins.
The Journal of biological chemistry 1992;267(2):1099-103.
1992: Mien-Chie Hung; X Zhang; Duen-Hwa Yan; H Z Zhang; G P He; T Q Zhang; D R Shi
Aberrant expression of the c-erbB-2/neu protooncogene in ovarian cancer.
Cancer letters 1992;61(2):95-103.
1991: D H Yu; Mien-Chie Hung
Expression of activated rat neu oncogene is sufficient to induce experimental metastasis in 3T3 cells.
Oncogene 1991;6(11):1991-6.
1991: Toshihiko Utsumi; Mien-Chie Hung; Jim Klostergaard
Preparation and characterization of liposomal-lipophilic tumor necrosis factor.
Cancer research 1991;51(13):3362-6.
1991: Duen-Hwa Yan; Mien-Chie Hung
Identification and characterization of a novel enhancer for the rat neu promoter.
Molecular and cellular biology 1991;11(4):1875-82.
1991: D H Yu; K Scorsone; Mien-Chie Hung
Adenovirus type 5 E1A gene products act as transformation suppressors of the neu oncogene.
Molecular and cellular biology 1991;11(3):1745-50.
1991: Duen-Hwa Yan; Long-sheng Chang; Mien-Chie Hung
Repressed expression of the HER-2/c-erbB-2 proto-oncogene by the adenovirus E1a gene products.
Oncogene 1991;6(2):343-5.
1991: T C Suen; Mien-Chie Hung
c-myc reverses neu-induced transformed morphology by transcriptional repression.
Molecular and cellular biology 1991;11(1):354-62.
1990: T C Suen; Mien-Chie Hung
Multiple cis- and trans-acting elements involved in regulation of the neu gene.
Molecular and cellular biology 1990;10(12):6306-15.
1990: Dihua Yu; T C Suen; Duen-Hwa Yan; Long-sheng Chang; Mien-Chie Hung
Transcriptional repression of the neu protooncogene by the adenovirus 5 E1A gene products.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(12):4499-503.
1990: H Saya; S Ara; P S Lee; Jae Y Ro; Mien-Chie Hung
Direct sequencing analysis of transmembrane region of human Neu gene by polymerase chain reaction.
Molecular carcinogenesis 1990;3(4):198-201.
1990: T C Suen; R U Rodriguez; Mien-Chie Hung; Jim Klostergaard
V-abl confers resistance and growth advantage to TNF-alpha in NIH3T3 cells.
Lymphokine research 1990;9(1):15-26.
1990: A Matin; K L Cheng; T C Suen; Mien-Chie Hung
Effect of glucocorticoids on oncogene transformed NIH3T3 cells.
Oncogene 1990;5(1):111-6.
1990: Haiyen E Zhau; X Zhang; Andrew C von Eschenbach; K Scorsone; R J Babaian; Jae Y Ro; Mien-Chie Hung
Amplification and expression of the c-erb B-2/neu proto-oncogene in human bladder cancer.
Molecular carcinogenesis 1990;3(5):254-7.
1989: P M Schneider; Mien-Chie Hung; S M Chiocca; J Manning; X Y Zhao; K Fang; Jack A Roth
Differential expression of the c-erbB-2 gene in human small cell and non-small cell lung cancer.
Cancer research 1989;49(18):4968-71.
1989: X Zhang; E Silva; D Gershenson; Mien-Chie Hung
Amplification and rearrangement of c-erb B proto-oncogenes in cancer of human female genital tract.
Oncogene 1989;4(8):985-9.
1989: Mien-Chie Hung; Duen-Hwa Yan; X Y Zhao
Amplification of the proto-neu oncogene facilitates oncogenic activation by a single point mutation.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(8):2545-8.
1988: PA Steck; P Lee; Mien-Chie Hung; W K Alfred Yung
Expression of an altered epidermal growth factor receptor by human glioblastoma cells.
Cancer research 1988;48(19):5433-9.