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Thomas Hünig

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Tea Gogishvili; Sandra Beer-Hammer; Sandra Goebbels; Fred Lühder; Klaus Pfeffer; Thomas Hünig
Cell-intrinsic and -extrinsic control of Treg-cell homeostasis and function revealed by induced CD28 deletion.
Tea Gogishvili; Sandra Beer-Hammer; Frank Brombacher; Sandra Goebbels; Frank Kirstein; Fred Lühder; Natalie Nieuwenhuizen; Klaus Pfeffer; Sebastian Reuter; Christian Taube; Thomas Hünig
Interruption of CD28-mediated costimulation during allergen challenge protects mice from allergic airway disease.
Shin-Young Na; Monica Sanchez-Ruiz; Alexander Storch; Martina Deckert; Andreas Hermann; Thomas Hünig
Oligodendrocytes enforce immune tolerance of the uninfected brain by purging the peripheral repertoire of autoreactive CD8+ T cells.

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2013: Tea Gogishvili; Sandra Beer-Hammer; Sandra Goebbels; Fred Lühder; Klaus Pfeffer; Thomas Hünig
Cell-intrinsic and -extrinsic control of Treg-cell homeostasis and function revealed by induced CD28 deletion.
European journal of immunology 2013;43(1):188-93.
2012: Tea Gogishvili; Sandra Beer-Hammer; Frank Brombacher; Sandra Goebbels; Frank Kirstein; Fred Lühder; Natalie Nieuwenhuizen; Klaus Pfeffer; Sebastian Reuter; Christian Taube; Thomas Hünig
Interruption of CD28-mediated costimulation during allergen challenge protects mice from allergic airway disease.
The Journal of allergy and clinical immunology 2012;130(6):1394-403.e4.
2012: Shin-Young Na; Monica Sanchez-Ruiz; Alexander Storch; Martina Deckert; Andreas Hermann; Thomas Hünig
Oligodendrocytes enforce immune tolerance of the uninfected brain by purging the peripheral repertoire of autoreactive CD8+ T cells.
Immunity 2012;37(1):134-46.
2012: Josef Bodor; Christian Becker; Thomas Hünig; Matthias Klein; Hansjörg Schild; Edgar Serfling; Martin Vaeth; Christian Becker; Edgar Schmitt
Cyclic AMP underpins suppression by regulatory T cells.
European journal of immunology 2012;42(6):1375-84.
2012: Daniela Langenhorst; Manfred B Lutz; Kirsty McPherson; Eliana Ribechini; Tea Gogishvili; Susanne Kneitz; Thomas Hünig
Sequential induction of effector function, tissue migration and cell death during polyclonal activation of mouse regulatory T-cells.
PloS one 2012;7(11):e50080.
2012: Dajana Reuter; Thomas Hünig; Tim D. Sparwasser; Jürgen Schneider-Schaulies
Foxp3+ regulatory T cells control persistence of viral CNS infection.
PloS one 2012;7(3):e33989.
2011: Paula Tabares; Thomas Hünig; Sheila M Pimentel-Elardo; Tanja Schirmeister; Ute Hentschel
Anti-protease and immunomodulatory activities of bacteria associated with Caribbean sponges.
Marine biotechnology (New York, N.Y.) 2011;13(5):883-92.
2011: Martin Vaeth; Tea Gogishvili; Tobias Bopp; Matthias Klein; Friederike Berberich-Siebelt; Stefan Gattenloehner; Andris Avots; Tim D. Sparwasser; Nadine Grebe; Edgar Schmitt; Thomas Hünig; Edgar Serfling; Josef Bodor
Regulatory T cells facilitate the nuclear accumulation of inducible cAMP early repressor (ICER) and suppress nuclear factor of activated T cell c1 (NFATc1).
Proceedings of the National Academy of Sciences of the United States of America 2011;108(6):2480-5.
2010: Thomas Hünig; Fred Lühder; Karin Elflein; Tea Gogishvili; Monika Fröhlich; Reto Guler; Antony Cutler; Frank Brombacher
CD28 and IL-4: two heavyweights controlling the balance between immunity and inflammation.
Medical microbiology and immunology 2010;199(3):239-46.
2010: Kai Michaelis; Katrin Wallbrecht; Andreas Kerstan; Niklas Beyersdorf; Cortny Williams; Thomas Kerkau; Xiao-Jing Wang; Thomas Hünig; Michael P Schön
Modulating T cell functions does not alleviate chronic inflammatory skin lesions in K5.TGF beta 1 transgenic mice.
Experimental dermatology 2010;19(5):406-15.
2010: Kerstin Göbel; Nico Melzer; Alexander M Herrmann; Michael K Schuhmann; Stefan Bittner; Chi Wang Ip; Thomas Hünig; Sven G Meuth; Heinz Wiendl
Collateral neuronal apoptosis in CNS gray matter during an oligodendrocyte-directed CD8(+) T cell attack.
Glia 2010;58(4):469-80.
2010: Yusuke Kitazawa; Xiao-Kang Li; Zhong Liu; Hiromitsu Kimura; Yoshitaka Isaka; Thomas Hünig; Shiro Takahara
Prevention of graft-versus-host diseases by in vivo supCD28mAb-expanded antigen-specific nTreg cells.
Cell transplantation 2010;19(6):765-74.
2009: Niklas Beyersdorf; Xin Ding; Thomas Hünig; Thomas Kerkau
Superagonistic CD28 stimulation of allogeneic T cells protects from acute graft-versus-host disease.
Blood 2009;114(20):4575-82.
2009: Shin-Young Na; Heike Eujen; Kerstin Göbel; Sven G Meuth; Kati Martens; Heinz Wiendl; Thomas Hünig
Antigen-specific blockade of lethal CD8 T-cell mediated autoimmunity in a mouse model of multiple sclerosis.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(10):6569-75.
2009: Yusuke Kitazawa; Masayuki Fujino; Xiao-Kang Li; Lin Xie; Naotsugu Ichimaru; Masayoshi Okumi; Norio Nonomura; Akira Tsujimura; Yoshitaka Isaka; Hiromitsu Kimura; Thomas Hünig; Shiro Takahara
Superagonist CD28 antibody preferentially expanded Foxp3-expressing nTreg cells and prevented graft-versus-host diseases.
Cell transplantation 2009;18(5):627-37.
2009: Tea Gogishvili; Daniela Langenhorst; Fred Lühder; Fernando Elias; Karin Elflein; Kevin M Dennehy; Ralf Gold; Thomas Hünig
Rapid regulatory T-cell response prevents cytokine storm in CD28 superagonist treated mice.
PloS one 2009;4(2):e4643.
2008: Niklas Beyersdorf; Xin Ding; Gregor Blank; Kevin M Dennehy; Thomas Kerkau; Thomas Hünig
Protection from graft-versus-host disease with a novel B7 binding site-specific mouse anti-mouse CD28 monoclonal antibody.
Blood 2008;112(10):4328-36.
2008: Tea Gogishvili; Fernando Elias; Juliet L Emery; Kirsty McPherson; Klaus Okkenhaug; Thomas Hünig; Kevin M Dennehy
Proliferative signals mediated by CD28 superagonists require the exchange factor Vav1 but not phosphoinositide 3-kinase in primary peripheral T cells.
European journal of immunology 2008;38(9):2528-33.
2008: Shin-Young Na; Yi Cao; Catherine Toben; Lars Nitschke; Christine Stadelmann; Ralf Gold; Anneliese Schimpl; Thomas Hünig
Naive CD8 T-cells initiate spontaneous autoimmunity to a sequestered model antigen of the central nervous system.
Brain : a journal of neurology 2008;131(Pt 9):2353-65.
2008: Martin Guilliams; T Bosschaerts; Michel Hérin; Thomas Hünig; Patrizia Loi; Véronique Flamand; Patrick De Baetselier; Alain Beschin
Experimental expansion of the regulatory T cell population increases resistance to African trypanosomiasis.
The Journal of infectious diseases 2008;198(5):781-91.
2008: Yusuke Kitazawa; Masayuki Fujino; Takatoshi Sakai; Haruhito Azuma; Hiromitsu Kimura; Yoshitaka Isaka; Shiro Takahara; Thomas Hünig; Ryo Abe; Xiao-Kang Li
Foxp3-expressing regulatory T cells expanded with CD28 superagonist antibody can prevent rat cardiac allograft rejection.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2008;27(4):362-71.
2007: Kevin M Dennehy; Fernando Elias; Shin-Young Na; Klaus-Dieter Fischer; Thomas Hünig; Fred Lühder
Mitogenic CD28 signals require the exchange factor Vav1 to enhance TCR signaling at the SLP-76-Vav-Itk signalosome.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(3):1363-71.
2007: Thomas Hünig
Manipulation of regulatory T-cell number and function with CD28-specific monoclonal antibodies.
Advances in immunology 2007;95():111-48.
2006: Andreas Kerstan; Nicole Armbruster; Martin Leverkus; Thomas Hünig
Cyclosporin A abolishes CD28-mediated resistance to CD95-induced apoptosis via superinduction of caspase-3.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(11):7689-97.
2006: Niklas Beyersdorf; Karen Balbach; Thomas Hünig; Thomas Kerkau
Large-scale expansion of rat CD4+ CD25+ T(reg) cells in the absence of T-cell receptor stimulation.
Immunology 2006;119(4):441-50.
2006: Amiya K Patra; Thomas Drewes; Swen Engelmann; Sergei Chuvpilo; Hiroyuki Kishi; Thomas Hünig; Edgar Serfling; Ursula Bommhardt
PKB rescues calcineurin/NFAT-induced arrest of Rag expression and pre-T cell differentiation.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(7):4567-76.
2006: Denise Tischner; Andreas Weishaupt; Jens van den Brandt; Nora Müller; Niklas Beyersdorf; Chi Wang Ip; Klaus V Toyka; Thomas Hünig; Ralf Gold; Thomas Kerkau; Holger M Reichardt
Polyclonal expansion of regulatory T cells interferes with effector cell migration in a model of multiple sclerosis.
Brain : a journal of neurology 2006;129(Pt 10):2635-47.
2006: Kevin M Dennehy; Fernando Elias; Gabrielle Zeder-Lutz; Xin Ding; Danièle Altschuh; Fred Lühder; Thomas Hünig
Cutting edge: monovalency of CD28 maintains the antigen dependence of T cell costimulatory responses.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(10):5725-9.
2006: María Rodríguez-Palmero; Angels Franch; Margarida Castell; Carme Pelegrí; Francisco J Pérez-Cano; Christoph Kleinschnitz; Guido Stoll; Thomas Hünig; Cristina Castellote
Effective treatment of adjuvant arthritis with a stimulatory CD28-specific monoclonal antibody.
The Journal of rheumatology 2006;33(1):110-8.
2006: Yi Cao; Catherine Toben; Shin-Young Na; Kirsten Stark; Lars Nitschke; Alan Peterson; Ralf Gold; Anneliese Schimpl; Thomas Hünig
Induction of experimental autoimmune encephalomyelitis in transgenic mice expressing ovalbumin in oligodendrocytes.
European journal of immunology 2006;36(1):207-15.
2006: Niklas Beyersdorf; Thomas Hanke; Thomas Kerkau; Thomas Hünig
CD28 superagonists put a break on autoimmunity by preferentially activating CD4+CD25+ regulatory T cells.
Autoimmunity reviews 2006;5(1):40-5.
2005: Niklas Beyersdorf; Thomas Hanke; Thomas Kerkau; Thomas Hünig
Superagonistic anti-CD28 antibodies: potent activators of regulatory T cells for the therapy of autoimmune diseases.
Annals of the rheumatic diseases 2005;64 Suppl 4():iv91-5.
2005: Thomas Hünig; Kevin M Dennehy
CD28 superagonists: mode of action and therapeutic potential.
Immunology letters 2005;100(1):21-8.
2005: Niklas Beyersdorf; Stefanie Gaupp; Karen Balbach; Jens Schmidt; Klaus V Toyka; Chia-Huey Lin; Thomas Hanke; Thomas Hünig; Thomas Kerkau; Ralf Gold
Selective targeting of regulatory T cells with CD28 superagonists allows effective therapy of experimental autoimmune encephalomyelitis.
The Journal of experimental medicine 2005;202(3):445-55.
2005: Jens van den Brandt; Soon-Hwan Kwon; Thomas Hünig; Kirsty G McPherson; Holger M Reichardt
Sustained pre-TCR expression in Notch1IC-transgenic rats impairs T cell maturation and selection.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(12):7845-52.
2005: Edward J Evans; Robert M Esnouf; Raquel Manso-Sancho; Robert J C Gilbert; John R James; Chao Yu; Janet A Fennelly; Cheryl Vowles; Thomas Hanke; Björn Walse; Thomas Hünig; Poul Sørensen; David I Stuart; Simon J Davis
Crystal structure of a soluble CD28-Fab complex.
Nature immunology 2005;6(3):271-9.
2004: Jens van den Brandt; Katrin Voss; Melanie Schott; Thomas Hünig; Michael S Wolfe; Holger M Reichardt
Inhibition of Notch signaling biases rat thymocyte development towards the NK cell lineage.
European journal of immunology 2004;34(5):1405-13.
2004: Ursula Bommhardt; M Beyer; Thomas Hünig; Holger M Reichardt
Molecular and cellular mechanisms of T cell development.
Cellular and molecular life sciences : CMLS 2004;61(3):263-80.
2004: Lucian Visan; Ioana A Visan; Andreas Weishaupt; Harald H Hofstetter; Klaus V Toyka; Thomas Hünig; Ralf Gold
Tolerance induction by intrathymic expression of P0.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(3):1364-70.
2004: Andreas Kerstan; Thomas Hünig
Cutting edge: distinct TCR- and CD28-derived signals regulate CD95L, Bcl-xL, and the survival of primary T cells.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(3):1341-5.
2003: Karin Elflein; Marta Rodriguez-Palmero; Thomas Kerkau; Thomas Hünig
Rapid recovery from T lymphopenia by CD28 superagonist therapy.
Blood 2003;102(5):1764-70.
2003: Shin-Young Na; Amiya K Patra; Yvonne Scheuring; Alexander Marx; Mauro Tolaini; Dimitris Kioussis; Brian A Hemmings; Brian Hemmings; Thomas Hünig; Ursula Bommhardt
Constitutively active protein kinase B enhances Lck and Erk activities and influences thymocyte selection and activation.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(3):1285-96.
2003: Jens Schmidt; Karin Elflein; Martina Stienekemeier; Marta Rodriguez-Palmero; Christiane Schneider; Klaus V Toyka; Ralf Gold; Thomas Hünig
Treatment and prevention of experimental autoimmune neuritis with superagonistic CD28-specific monoclonal antibodies.
Journal of neuroimmunology 2003;140(1-2):143-52.
2003: Kevin M Dennehy; Andreas Kerstan; Astrid Bischof; Jung-Hyun Park; Shin-Young Na; Thomas Hünig
Mitogenic signals through CD28 activate the protein kinase Ctheta-NF-kappaB pathway in primary peripheral T cells.
International immunology 2003;15(5):655-63.
2003: Fred Lühder; Yun Huang; Kevin M Dennehy; Christine Guntermann; Ingrid Müller; Erna Winkler; Thomas Kerkau; Shinji Ikemizu; Simon J Davis; Thomas Hanke; Thomas Hünig
Topological requirements and signaling properties of T cell-activating, anti-CD28 antibody superagonists.
The Journal of experimental medicine 2003;197(8):955-66.
2003: Chia-Huey Lin; Thomas Hünig
Efficient expansion of regulatory T cells in vitro and in vivo with a CD28 superagonist.
European journal of immunology 2003;33(3):626-38.
2002: O Kutsch; T Vey; Thomas Kerkau; Thomas Hünig; Anneliese Schimpl
HIV type 1 abrogates TAP-mediated transport of antigenic peptides presented by MHC class I. Transporter associated with antigen presentation.
AIDS research and human retroviruses 2002;18(17):1319-25.
2002: Sibylle Schneider-Schaulies; Bertus K Rima; Thomas Hünig
Viral pathogenesis and immune control.
Journal of neurovirology 2002;8(5):464-9.
2002: Christoph Otto; S Feuerlein; Wolfgang Timmermann; Karin Ulrichs; Thomas Hünig; Arnulf Thiede; Heinz-Jochen Gassel
Investigation of the immunosuppressive potential of anti-CD28 antibodies for selective inhibition of the T-cell mediated alloresponse.
Transplantation proceedings 2002;34(6):2376.
2002: Anneliese Schimpl; Ingolf Berberich; Burkhard Kneitz; Susanne Krämer; Brigitte Santner-Nanan; Sabine Wagner; Martina Wolf; Thomas Hünig
IL-2 and autoimmune disease.
Cytokine & growth factor reviews 2002;13(4-5):369-78.
2002: Susanne Marschner; Thomas Hünig; John C Cambier; Terri H Finkel
Ligation of human CD4 interferes with antigen-induced activation of primary T cells.
Immunology letters 2002;82(1-2):131-9.
2001: Thomas Hünig; N Torres-Nagel; BE Mehling; H J Park; Thomas Herrmann
Thymic development and repertoire selection: the rat perspective.
Immunological reviews 2001;184():7-19.
2001: M Wolf; Anneliese Schimpl; Thomas Hünig
Control of T cell hyperactivation in IL-2-deficient mice by CD4(+)CD25(-) and CD4(+)CD25(+) T cells: evidence for two distinct regulatory mechanisms.
European journal of immunology 2001;31(6):1637-45.
2001: N Torres-Nagel; BE Mehling; A F LeRolle; Etienne Joly; Thomas Hünig
Genetic control of peripheral TCRAV usage by representation in the preselection repertoire and MHC allele-specific overselection.
International immunology 2001;13(1):63-73.
2000: Astrid Bischof; T Hara; Chia-Huey Lin; A D Beyers; Thomas Hünig
Autonomous induction of proliferation, JNK and NF-alphaB activation in primary resting T cells by mobilized CD28.
European journal of immunology 2000;30(3):876-82.
2000: Ursula Bommhardt; Y Scheuring; C Bickel; Rose Zamoyska; Thomas Hünig
MEK activity regulates negative selection of immature CD4+CD8+ thymocytes.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(5):2326-37.
2000: Astrid Bischof; J H Park; Thomas Hünig
Expression of T-cell receptor beta-chain mRNA and protein in gamma/delta T-cells from euthymic and athymic rats: implications for T-cell lineage divergence.
Developmental immunology 2000;8(1):19-30.
1999: María Rodríguez-Palmero; T Hara; A Thumbs; Thomas Hünig
Triggering of T cell proliferation through CD28 induces GATA-3 and promotes T helper type 2 differentiation in vitro and in vivo.
European journal of immunology 1999;29(12):3914-24.
1999: K Neben; M Heidbreder; Justus Müller; A Marxer; H Petry; A Didier; Anneliese Schimpl; Thomas Hünig; Thomas Kerkau
Impaired thymopoietic potential of immature CD3(-)CD4(+)CD8(-) T cell precursors from SIV-infected rhesus monkeys.
International immunology 1999;11(9):1509-18.
1999: Susanne Marschner; Benjamin A Freiberg; Abraham Kupfer; Thomas Hünig; Terri H Finkel
Ligation of the CD4 receptor induces activation-independent down-regulation of L-selectin.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(17):9763-8.
1999: Thomas Herrmann; K Hofmann; N E Nagel; A Asmuss; Thomas Hünig; K Wonigeit
Differential CD4/CD8 subset-specific expression of highly homologous rat Tcrb-V8 family members suggests a role of CDR2 and/or CDR4 (HV4) in MHC class-specific thymic selection.
International immunology 1999;11(3):435-44.
1998: Brigitte Santner-Nanan; S Wagner; M Wolf; Burkhard Kneitz; Thomas Hünig; Anneliese Schimpl
In vitro skewing of TCR transgenic CD4+ T cells from interleukin-2 deficient mice towards Th1 and Th2 in the absence of exogenous interleukin-2.
European cytokine network 1998;9(3 Suppl):17-25.
1998: R Nenninger; A Schultz; Viola Hoffacker; Markus Helmreich; A Wilisch; B Vandekerckhove; Thomas Hünig; Berthold Schalke; Christiane Schneider; S Tzartos; H Kalbacher; Hans Konrad Müller-Hermelink; Alexander Marx
Abnormal thymocyte development and generation of autoreactive T cells in mixed and cortical thymomas.
Laboratory investigation; a journal of technical methods and pathology 1998;78(6):743-53.
1998: Etienne Joly; Anne-France Le Rolle; A L González; BE Mehling; J Stevens; W John Coadwell; Thomas Hünig; Jonathan C Howard; Geoffrey W Butcher
Co-evolution of rat TAP transporters and MHC class I RT1-A molecules.
Current biology : CB 1998;8(3):169-72.
1998: R Mitnacht; Astrid Bischof; N Torres-Nagel; Thomas Hünig
Opposite CD4/CD8 lineage decisions of CD4+8+ mouse and rat thymocytes to equivalent triggering signals: correlation with thymic expression of a truncated CD8 alpha chain in mice but not rats.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(2):700-7.
1997: Thomas Hünig; Anneliese Schimpl
Systemic autoimmune disease as a consequence of defective lymphocyte death.
Current opinion in immunology 1997;9(6):826-30.
1997: N Torres-Nagel; A Deutschländer; Thomas Herrmann; B Arden; Thomas Hünig
Control of TCR V alpha-mediated positive repertoire selection and alloreactivity by differential J alpha usage and CDR3 alpha composition.
International immunology 1997;9(10):1441-52.
1997: M Tacke; G Hanke; Thomas Hanke; Thomas Hünig
CD28-mediated induction of proliferation in resting T cells in vitro and in vivo without engagement of the T cell receptor: evidence for functionally distinct forms of CD28.
European journal of immunology 1997;27(1):239-47.
1996: P Kühnlein; R Mitnacht; N Torres-Nagel; Thomas Herrmann; A Elbe; Thomas Hünig
The canonical T cell receptor of dendritic epidermal gamma delta T cells is highly conserved between rats and mice.
European journal of immunology 1996;26(12):3092-7.
1996: A Asmuss; K Hofmann; T Hochgrebe; G Giegerich; Thomas Hünig; Thomas Herrmann
Alleles of highly homologous rat T cell receptor beta-chain variable segments 8.2 and 8.4: strain-specific expression, reactivity to superantigens, and binding of the mAb R78.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(10):4436-41.
1996: E Kraus; D Lambracht; K Wonigeit; Thomas Hünig
Negative regulation of rat natural killer cell activity by major histocompatibility complex class I recognition.
European journal of immunology 1996;26(11):2582-6.
1996: J H Park; T Hanke; Thomas Hünig
Identification and cellular distribution of the rat interleukin-2 receptor beta chain: induction of the IL-2R alpha- beta+ phenotype by major histocompatibility complex class I recognition during T cell development in vivo and by T cell receptor stimulation of CD4+8+ immature thymocytes in vitro.
European journal of immunology 1996;26(10):2371-5.
1996: Carme Pelegrí; P Kühnlein; Eberhard Buchner; C B Schmidt; Angels Franch; Margarida Castell; Thomas Hünig; Frank Emmrich; Raimund W Kinne
Depletion of gamma/delta T cells does not prevent or ameliorate, but rather aggravates, rat adjuvant arthritis.
Arthritis and rheumatism 1996;39(2):204-15.
1995: S Krämer; Anneliese Schimpl; Thomas Hünig
Immunopathology of interleukin (IL) 2-deficient mice: thymus dependence and suppression by thymus-dependent cells with an intact IL-2 gene.
The Journal of experimental medicine 1995;182(6):1769-76.
1995: H Imrich; C Kugler; N Torres-Nagel; Rüdiger Dörries; Thomas Hünig
Prevention and treatment of Lewis rat experimental allergic encephalomyelitis with a monoclonal antibody to the T cell receptor V beta 8.2 segment.
European journal of immunology 1995;25(7):1960-4.
1995: M Tacke; G J Clark; Margaret J Dallman; Thomas Hünig
Cellular distribution and costimulatory function of rat CD28. Regulated expression during thymocyte maturation and induction of cyclosporin A sensitivity of costimulated T cell responses by phorbol ester.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(10):5121-7.
1995: Klaus J Erb; T Hanke; Anneliese Schimpl; Thomas Hünig; Georg Stingl; A Elbe
Impaired survival of T cell receptor V gamma 3+ cells in interleukin-4 transgenic mice.
European journal of immunology 1995;25(5):1442-5.
1995: C McMenamin; M McKersey; P Kühnlein; Thomas Hünig; Patrick G Holt
Gamma delta T cells down-regulate primary IgE responses in rats to inhaled soluble protein antigens.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(9):4390-4.
1995: J Lannes-Viera; B Goudable; K Drexler; J Gehrmann; N Torres-Nagel; Thomas Hünig; Hartmut Wekerle
Encephalitogenic, myelin basic protein-specific T cells from naive rat thymus: preferential use of the T cell receptor gene V beta 8.2 and expression of the CD4-CD8- phenotype.
European journal of immunology 1995;25(2):611-6.
1995: R Mitnacht; M Tacke; Thomas Hünig
Expression of cell interaction molecules by immature rat thymocytes during passage through the CD4+8+ compartment: developmental regulation and induction by T cell receptor engagement of CD2, CD5, CD28, CD11a, CD44 and CD53.
European journal of immunology 1995;25(2):328-32.
1995: P Kühnlein; Angeles Vicente; Alberto Varas; Thomas Hünig; A Zapata
Gamma/delta T cells in fetal, neonatal, and adult rat lymphoid organs.
Developmental immunology 1995;4(3):181-8.
1995: M Stangel; G Giegerich; N Torres-Nagel; Thomas Hünig; Hans-Peter Hartung
Structural analysis of the rat T-cell receptor Tcra V4 gene family.
Immunogenetics 1995;41(2-3):125-30.
1995: G Giegerich; M Stangel; N Torres-Nagel; Thomas Hünig; Klaus V Toyka
Sequence and diversity of rat T-cell receptor Tcra V8 gene segments.
Immunogenetics 1995;42(4):304-5.
1994: T Hanke; R Mitnacht; R Boyd; Thomas Hünig
Induction of interleukin 2 receptor beta chain expression by self-recognition in the thymus.
The Journal of experimental medicine 1994;180(5):1629-36.
1994: N Torres-Nagel; Thomas Herrmann; G Giegerich; K Wonigeit; Thomas Hünig
Preferential TCR V usage in rat repertoire selection: V alpha 8 imparts both positive thymic selection by and alloreactivity to RT1f.
International immunology 1994;6(9):1367-73.
1994: P Kühnlein; J H Park; Thomas Herrmann; A Elbe; Thomas Hünig
Identification and characterization of rat gamma/delta T lymphocytes in peripheral lymphoid organs, small intestine, and skin with a monoclonal antibody to a constant determinant of the gamma/delta T cell receptor.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(3):979-86.
1994: Thomas Herrmann; T Hochgrebe; N Torres-Nagel; B T Huber; Thomas Hünig
Control of the rat T cell response to retroviral and bacterial superantigens by class II MHC products and Tcrb-V8.2 alleles.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(9):4300-9.
1994: N Torres-Nagel; G Giegerich; D P Gold; Thomas Hünig
Identification of rat Tcra-V 4 and 8 gene products by monoclonal antibodies and cDNA sequence.
Immunogenetics 1994;39(5):367-70.
1994: A Elbe; O Kilgus; Thomas Hünig; Georg Stingl
T-cell receptor diversity in dendritic epidermal T cells in the rat.
The Journal of investigative dermatology 1994;102(1):74-9.
1993: N Torres-Nagel; Thomas Herrmann; D P Gold; Thomas Hünig
Analysis of the rat T-cell receptor repertoire and superantigen reactivity with TCR V-specific monoclonal antibodies.
Transplantation proceedings 1993;25(5):2778-9.
1993: C Kneitz; Thomas Kerkau; Justus Müller; Cheick Coulibaly; Christiane Stahl-Hennig; Gerhard Hunsmann; Thomas Hünig; Anneliese Schimpl
Early phenotypic and functional alterations in lymphocytes from simian immunodeficiency virus infected macaques.
Veterinary immunology and immunopathology 1993;36(3):239-55.
1993: J H Park; R Mitnacht; N Torres-Nagel; Thomas Hünig
T cell receptor ligation induces interleukin (IL) 2R beta chain expression in rat CD4,8 double positive thymocytes, initiating an IL-2-dependent differentiation pathway of CD8 alpha+/beta- T cells.
The Journal of experimental medicine 1993;177(2):541-6.
1993: N Torres-Nagel; D P Gold; Thomas Hünig
Identification of rat Tcrb-V8.2, 8.5, and 10 gene products by monoclonal antibodies.
Immunogenetics 1993;37(4):305-8.
1992: N Torres-Nagel; E Kraus; M H Brown; G Tiefenthaler; R Mitnacht; A F Williams; Thomas Hünig
Differential thymus dependence of rat CD8 isoform expression.
European journal of immunology 1992;22(11):2841-8.
1992: G Tiefenthaler; T Hanke; Thomas Hünig
Maturation of CD4-8- alpha/beta TCR+ T cells induced by CD2-stimulation in vivo and in vitro.
International immunology 1992;4(7):825-9.
1992: Stefan Jung; S Krämer; Hermann J Schluesener; Thomas Hünig; Klaus V Toyka; Hans-Peter Hartung
Prevention and therapy of experimental autoimmune neuritis by an antibody against T cell receptors-alpha/beta.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(12):3768-75.
1991: A Lawetzky; M Kubbies; Thomas Hünig
Rat "first-wave" mature thymocytes: cycling lymphoblasts that are sensitive to activation-induced cell death but rescued by interleukin 2.
European journal of immunology 1991;21(10):2599-604.
1991: H Schorle; T Holtschke; Thomas Hünig; Anneliese Schimpl; Ivan Horak
Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting.
Nature 1991;352(6336):621-4.
1991: Thomas Hünig; R Mitnacht
T cell receptor-mediated selection of functional rat CD8 T cells from defined immature thymocyte precursors in short-term suspension culture.
The Journal of experimental medicine 1991;173(3):561-8.
1990: S Yoshino; E Schlipköter; R Kinne; Thomas Hünig; Frank Emmrich
Suppression and prevention of adjuvant arthritis in rats by a monoclonal antibody to the alpha/beta T cell receptor.
European journal of immunology 1990;20(12):2805-8.
1990: E Schlipköter; Thomas Hünig
The neonatally T cell receptor 2-suppressed rat: lymphocyte subset composition and immune reactivity.
European journal of immunology 1990;20(12):2621-7.
1990: A Lawetzky; G Tiefenthaler; R Kubo; Thomas Hünig
Identification and characterization of rat T cell subpopulations expressing T cell receptors alpha/beta and gamma/delta.
European journal of immunology 1990;20(2):343-9.
1990: S Yoshino; R Kinne; Thomas Hünig; Frank Emmrich
The suppressive effect of an antibody to the alpha beta cell receptor in rat adjuvant arthritis: studies on optimal treatment protocols.
Autoimmunity 1990;7(4):255-66.
1989: G Giegerich; W R Hein; M Miyasaka; G Tiefenthaler; Thomas Hünig
Restricted expression of CD2 among subsets of sheep thymocytes and T lymphocytes.
Immunology 1989;66(3):354-61.
1989: Thomas Hünig; H J Wallny; J K Hartley; A Lawetzky; G Tiefenthaler
A monoclonal antibody to a constant determinant of the rat T cell antigen receptor that induces T cell activation. Differential reactivity with subsets of immature and mature T lymphocytes.
The Journal of experimental medicine 1989;169(1):73-86.
1989: Thomas Hünig; G Tiefenthaler; A Lawetzky; R Kubo; E Schlipköter
T-cell subpopulations expressing distinct forms of the TCR in normal, athymic, and neonatally TCR alpha beta-suppressed rats.
Cold Spring Harbor symposia on quantitative biology 1989;54 Pt 1():61-8.
1989: G Tiefenthaler; Thomas Hünig
The role of CD2/LFA-3 interaction in antigen- and mitogen-induced activation of human T cells.
International immunology 1989;1(2):169-75.
1988: Thomas Hünig
Cross-linking of the T cell antigen receptor interferes with the generation of CD4+8+ thymocytes from their immediate CD4-8+ precursors.
European journal of immunology 1988;18(12):2089-92.
1988: A Lawetzky; Thomas Hünig
Analysis of CD3 and antigen receptor expression on T cell subpopulations of aged athymic mice.
European journal of immunology 1988;18(3):409-16.
1987: G Tiefenthaler; Thomas Hünig; M L Dustin; T A Springer; S C Meuer
Purified lymphocyte function-associated antigen-3 and T11 target structure are active in CD2-mediated T cell stimulation.
European journal of immunology 1987;17(12):1847-50.
1987: Periasamy Selvaraj; Michael L Dustin; R Mitnacht; Thomas Hünig; Timothy A Springer; M L Plunkett
Rosetting of human T lymphocytes with sheep and human erythrocytes. Comparison of human and sheep ligand binding using purified E receptor.
Journal of immunology (Baltimore, Md. : 1950) 1987;139(8):2690-5.
1987: G Tiefenthaler; M L Dustin; T A Springer; Thomas Hünig
Serologic cross-reactivity of T11 target structure and lymphocyte function-associated antigen 3. Evidence for structural homology of the sheep and human ligands of CD2.
Journal of immunology (Baltimore, Md. : 1950) 1987;139(8):2696-701.
1987: Thomas Hünig; G Tiefenthaler; R Mitnacht; C Köhler; F Lottspeich; S Meuer
The "erythrocyte receptor" of T-lymphocytes and T11 target structure (T11TS): complementary cell interaction molecules involved in T-cell activation.
Behring Institute Mitteilungen 1987;(81):31-40.
1987: Thomas Hünig; G Tiefenthaler; K H Meyer zum Büschenfelde; S C Meuer
Alternative pathway activation of T cells by binding of CD2 to its cell-surface ligand.
Nature 1987;326(6110):298-301.
1987: Thomas Hünig; R Mitnacht; G Tiefenthaler; F Lottspeich
Isolation, biochemical analysis, and N-terminal amino acid sequence of a cell surface glycoprotein that binds to the "erythrocyte receptor" of T-lymphocytes.
Haematology and blood transfusion 1987;31():337-40.
1986: Thomas Hünig; R Mitnacht; G Tiefenthaler; C Köhler; M Miyasaka
T11TS, the cell surface molecule binding to the "erythrocyte receptor" of T lymphocytes: cellular distribution, purification to homogeneity and biochemical properties.
European journal of immunology 1986;16(12):1615-21.