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Douglas Auld

Research Profile

Chemicals & Drugs

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Tumor Cell Line

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Publications

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Patricia Dranchak; David H Drewry; Rajarshi Guha; Ryan MacArthur; William J Zuercher; Douglas S Auld; James Inglese
Profile of the GSK published protein kinase inhibitor set across ATP-dependent and-independent luciferases: implications for reporter-gene assays.
Mindy I Davis; Brooke M Emerling; Zhuyin Li; Sam Michael; Rajan Pragani; Atsuo T Sasaki; Min Shen; Douglas S Auld; Matthew Boxer; Lewis C Cantley; Kazutaka Sumita; Koh Takeuchi; Natasha Thorne; Anton Simeonov
A homogeneous, high-throughput assay for phosphatidylinositol 5-phosphate 4-kinase with a novel, rapid substrate preparation.
Martin J Walsh; Douglas S Auld; James M Bougie; Kyle R Brimacombe; Lewis C Cantley; Thomas Daniel; William J Israelsen; William Leister; Min Shen; Craig J Thomas; Matthew G Vander Heiden; Henrike Veith; Matthew B Boxer
2-Oxo-N-aryl-1,2,3,4-tetrahydroquinoline-6-sulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase.

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All Publications

2013: Patricia Dranchak; David H Drewry; Rajarshi Guha; Ryan MacArthur; William J Zuercher; Douglas S Auld; James Inglese
Profile of the GSK published protein kinase inhibitor set across ATP-dependent and-independent luciferases: implications for reporter-gene assays.
PloS one 2013;8(3):e57888.
2013: Mindy I Davis; Brooke M Emerling; Zhuyin Li; Sam Michael; Rajan Pragani; Atsuo T Sasaki; Min Shen; Douglas S Auld; Matthew Boxer; Lewis C Cantley; Kazutaka Sumita; Koh Takeuchi; Natasha Thorne; Anton Simeonov
A homogeneous, high-throughput assay for phosphatidylinositol 5-phosphate 4-kinase with a novel, rapid substrate preparation.
PloS one 2013;8(1):e54127.
2011: Martin J Walsh; Douglas S Auld; James M Bougie; Kyle R Brimacombe; Lewis C Cantley; Thomas Daniel; William J Israelsen; William Leister; Min Shen; Craig J Thomas; Matthew G Vander Heiden; Henrike Veith; Matthew B Boxer
2-Oxo-N-aryl-1,2,3,4-tetrahydroquinoline-6-sulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase.
Bioorganic & medicinal chemistry letters 2011;21(21):6322-7.
2011: Andrew S Rosenthal; Cordelle Tanega; Min Shen; Bryan T Mott; James M Bougie; Dac-Trung Nguyen; Tom Misteli; Douglas S Auld; David J Maloney; Craig J Thomas
Potent and selective small molecule inhibitors of specific isoforms of Cdc2-like kinases (Clk) and dual specificity tyrosine-phosphorylation-regulated kinases (Dyrk).
Bioorganic & medicinal chemistry letters 2011;21(10):3152-8.
2011: Sunita J Shukla; Srilatha Sakamuru; Ruili Huang; Timothy A Moeller; Paul Shinn; Danielle Vanleer; Douglas S Auld; Christopher P Austin; Menghang Xia
Identification of clinically used drugs that activate pregnane X receptors.
Drug metabolism and disposition: the biological fate of chemicals 2011;39(1):151-9.
2010: Natasha Thorne; James Inglese; Douglas S Auld
Illuminating insights into firefly luciferase and other bioluminescent reporters used in chemical biology.
Chemistry & biology 2010;17(6):646-57.
2010: Jian-kang Jiang; Matthew B Boxer; Matthew G Vander Heiden; Min Shen; Amanda P Skoumbourdis; Noel Southall; Henrike Veith; William Leister; Christopher P Austin; Hee Won Park; James Inglese; Lewis C Cantley; Douglas S Auld; Craig J Thomas
Evaluation of thieno[3,2-b]pyrrole[3,2-d]pyridazinones as activators of the tumor cell specific M2 isoform of pyruvate kinase.
Bioorganic & medicinal chemistry letters 2010;20(11):3387-93.
2010: Natasha Thorne; Douglas S Auld; James Inglese
Apparent activity in high-throughput screening: origins of compound-dependent assay interference.
Current opinion in chemical biology 2010;14(3):315-24.
2010: Douglas S Auld; Scott Lovell; Natasha Thorne; Wendy A Lea; David J Maloney; Min Shen; Ganesha Rai; Kevin P Battaile; Craig J Thomas; Anton Simeonov; Robert P Hanzlik; James Inglese
Molecular basis for the high-affinity binding and stabilization of firefly luciferase by PTC124.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(11):4878-83.
2010: Matthew B Boxer; Jian-kang Jiang; Matthew G Vander Heiden; Min Shen; Amanda P Skoumbourdis; Noel Southall; Henrike Veith; William Leister; Christopher P Austin; Hee Won Park; James Inglese; Lewis C Cantley; Douglas S Auld; Craig J Thomas
Evaluation of substituted N,N'-diarylsulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase.
Journal of medicinal chemistry 2010;53(3):1048-55.
2009: Cordelle Tanega; Min Shen; Bryan T Mott; Craig J Thomas; Ryan MacArthur; James Inglese; Douglas S Auld
Comparison of bioluminescent kinase assays using substrate depletion and product formation.
Assay and drug development technologies 2009;7(6):606-14.
2009: Bryan T Mott; Cordelle Tanega; Min Shen; David J Maloney; Paul Shinn; William Leister; Juan J Marugan; James Inglese; Christopher P Austin; Tom Misteli; Douglas S Auld; Craig J Thomas
Evaluation of substituted 6-arylquinazolin-4-amines as potent and selective inhibitors of cdc2-like kinases (Clk).
Bioorganic & medicinal chemistry letters 2009;19(23):6700-5.
2009: Henrike Veith; Noel Southall; Ruili Huang; Tim James; Darren Fayne; Natalia Artemenko; Min Shen; James Inglese; Christopher P Austin; David Lloyd; Douglas S Auld
Comprehensive characterization of cytochrome P450 isozyme selectivity across chemical libraries.
Nature biotechnology 2009;27(11):1050-5.
2009: Amanda P Skoumbourdis; Christopher A Leclair; Eduard Stefan; Adrian G Turjanski; William Maguire; Steven A Titus; Ruili Huang; Douglas S Auld; James Inglese; Christopher P Austin; Stephen W Michnick; Menghang Xia; Craig J Thomas
Exploration and optimization of substituted triazolothiadiazines and triazolopyridazines as PDE4 inhibitors.
Bioorganic & medicinal chemistry letters 2009;19(13):3686-92.
2009: Kyle R Brimacombe; Matthew D Hall; Douglas S Auld; James Inglese; Christopher P Austin; Michael M Gottesman; King-Leung Fung
A dual-fluorescence high-throughput cell line system for probing multidrug resistance.
Assay and drug development technologies 2009;7(3):233-49.
2009: Ryan MacArthur; William Leister; Henrike Veith; Paul Shinn; Noel Southall; Christopher P Austin; James Inglese; Douglas S Auld
Monitoring compound integrity with cytochrome P450 assays and qHTS.
Journal of biomolecular screening 2009;14(5):538-46.
2009: Sunita J Shukla; Dac-Trung Nguyen; Ryan Macarthur; Anton Simeonov; William J Frazee; Tina M Hallis; Bryan D Marks; Upinder Singh; Hildegard C Eliason; John Printen; Christopher P Austin; James Inglese; Douglas S Auld
Identification of pregnane X receptor ligands using time-resolved fluorescence resonance energy transfer and quantitative high-throughput screening.
Assay and drug development technologies 2009;7(2):143-69.
2009: Douglas S Auld; Ya-Qin Zhang; Noel Southall; Ganesha Rai; Marc Landsman; Jennifer MacLure; Daniel Langevin; Craig J Thomas; Christopher P Austin; James Inglese
A basis for reduced chemical library inhibition of firefly luciferase obtained from directed evolution.
Journal of medicinal chemistry 2009;52(5):1450-8.
2009: Douglas S Auld; Natasha Thorne; William F Maguire; James Inglese
Mechanism of PTC124 activity in cell-based luciferase assays of nonsense codon suppression.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(9):3585-90.
2009: Craig J Thomas; Douglas S Auld; Ruili Huang; Wenwei Huang; Ajit Jadhav; Ronald L Johnson; William Leister; David J Maloney; Juan J Marugan; Sam Michael; Anton Simeonov; Noel Southall; Menghang Xia; Wei Zheng; James Inglese; Christopher P Austin
The pilot phase of the NIH Chemical Genomics Center.
Current topics in medicinal chemistry 2009;9(13):1181-93.
2008: Sam Michael; Douglas S Auld; Carleen Klumpp; Ajit Jadhav; Wei Zheng; Natasha Thorne; Christopher P Austin; James Inglese; Anton Simeonov
A robotic platform for quantitative high-throughput screening.
Assay and drug development technologies 2008;6(5):637-57.
2008: Douglas S Auld; Natasha Thorne; Dac-Trung Nguyen; James Inglese
A specific mechanism for nonspecific activation in reporter-gene assays.
ACS chemical biology 2008;3(8):463-70.
2008: Douglas S Auld; Noel Southall; Ajit Jadhav; Ronald L Johnson; David J Diller; Anton Simeonov; Christopher P Austin; James Inglese
Characterization of chemical libraries for luciferase inhibitory activity.
Journal of medicinal chemistry 2008;51(8):2372-86.
2008: Anton Simeonov; Ajit Jadhav; Craig J Thomas; Yuhong Wang; Ruili Huang; Noel Southall; Paul Shinn; Jeremy Smith; Christopher P Austin; Douglas S Auld; James Inglese
Fluorescence spectroscopic profiling of compound libraries.
Journal of medicinal chemistry 2008;51(8):2363-71.
2008: Yuli Xie; ShiXian Deng; Craig J Thomas; Yidong Liu; Ya-Qin Zhang; Alison Rinderspacher; Wenwei Huang; Gangli Gong; Michael Wyler; Efithia Cayanis; Nathalie Aulner; Udo Többen; Caty Chung; Sergey Pampou; Noel Southall; Dusica Vidović; Stephen Schuerer; Lars Branden; R Eric Davis; Louis M Staudt; James Inglese; Christopher P Austin; Donald W Landry; Deborah H. Smith; Douglas S Auld
Identification of N-(quinolin-8-yl)benzenesulfonamides as agents capable of down-regulating NFkappaB activity within two separate high-throughput screens of NFkappaB activation.
Bioorganic & medicinal chemistry letters 2008;18(1):329-35.
2007: Wei Zheng; Janak Padia; Daniel J Urban; Ajit Jadhav; Ozlem Goker-Alpan; Anton Simeonov; Ehud Goldin; Douglas S Auld; Mary E LaMarca; James Inglese; Christopher P Austin; Ellen Sidransky
Three classes of glucocerebrosidase inhibitors identified by quantitative high-throughput screening are chaperone leads for Gaucher disease.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(32):13192-7.
2007: James Inglese; Ronald L Johnson; Anton Simeonov; Menghang Xia; Wei Zheng; Christopher P Austin; Douglas S Auld
High-throughput screening assays for the identification of chemical probes.
Nature chemical biology 2007;3(8):466-79.
2007: R Eric Davis; Ya-Qin Zhang; Noel Southall; Louis M Staudt; Christopher P Austin; James Inglese; Douglas S Auld
A cell-based assay for IkappaBalpha stabilization using a two-color dual luciferase-based sensor.
Assay and drug development technologies 2007;5(1):85-103.
2006: James Inglese; Douglas S Auld; Ajit Jadhav; Ronald L Johnson; Anton Simeonov; Adam Yasgar; Wei Zheng; Christopher P Austin
Quantitative high-throughput screening: a titration-based approach that efficiently identifies biological activities in large chemical libraries.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(31):11473-8.
2006: Koc-Kan Ho; Douglas S Auld; Adolph C Bohnstedt; Paolo Conti; Wim Dokter; Shawn Erickson; Daming Feng; James Inglese; Celia Kingsbury; Steven G Kultgen; Rong-Qiang Liu; Christopher M Masterson; Michael Ohlmeyer; Yajing Rong; Martijn Rooseboom; Andrew Roughton; Philippe Samama; Martin-Jan Smit; Ellen Son; Jaap van der Louw; Gerard Vogel; Maria Webb; Jac Wijkmans; Ming You
Imidazolylpyrimidine based CXCR2 chemokine receptor antagonists.
Bioorganic & medicinal chemistry letters 2006;16(10):2724-8.
2006: Douglas S Auld; Ronald L Johnson; Ya-qin Zhang; Henrike Veith; Ajit Jadhav; Adam Yasgar; Anton Simeonov; Wei Zheng; Elisabeth D Martinez; John K Westwick; Christopher P Austin; James Inglese
Fluorescent protein-based cellular assays analyzed by laser-scanning microplate cytometry in 1536-well plate format.
Methods in enzymology 2006;414():566-89.
2002: Eric Blasko; Charles B Glaser; James J Devlin; Wei Xia; Richard I Feldman; Mark A Polokoff; Gary B Phillips; Marc Whitlow; Douglas S Auld; Kirk McMillan; Sanjay Ghosh; Dennis J Stuehr; John Parkinson
Mechanistic studies with potent and selective inducible nitric-oxide synthase dimerization inhibitors.
The Journal of biological chemistry 2002;277(1):295-302.
2000: Kirk McMillan; M Adler; Douglas S Auld; John J Baldwin; Eric Blasko; L J Browne; Daniel Chelsky; D Davey; Roland E Dolle; Keith Eagen; Shawn Erickson; Richard I Feldman; Charles B Glaser; Cornell Mallari; Michael M Morrissey; Michael Ohlmeyer; G Pan; John Parkinson; Gary B Phillips; Mark A Polokoff; Nolan H Sigal; Ronald Vergona; Marc Whitlow; T A Young; James J Devlin
Allosteric inhibitors of inducible nitric oxide synthase dimerization discovered via combinatorial chemistry.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(4):1506-11.