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Christopher Hunter

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Kirk D C Jensen; Lindsay Julien; Diana Lu; Lieping Chen; Musa A Hassan; Kenneth Hu; Christopher A Hunter; Ryan J Whitmarsh; jeroen saeij
Toxoplasma gondii Rhoptry 16 Kinase Promotes Host Resistance to Oral Infection and Intestinal Inflammation Only in the Context of the Dense Granule Protein GRA15.
Emily Gwyer Findlay; Christopher A Hunter; Colette A Inkson; Eleanor M Riley; Christiaan J Saris; Tovah N Shaw; Ana Villegas; J Brian de Souza; Kevin N Couper
IL-27 receptor signaling regulates CD4+ T cell chemotactic responses during infection.
Ana Villegas; J Brian de Souza; Emily Gwyer Findlay; Christopher A Hunter; Seen-Wai Lavelle; Eleanor M Riley; Christiaan J Saris; Tovah N Shaw; Nico van Rooijen; Kevin N Couper
IL-27 receptor signalling restricts the formation of pathogenic, terminally differentiated Th1 cells during malaria infection by repressing IL-12 dependent signals.

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2013: Kirk D C Jensen; Lindsay Julien; Diana Lu; Lieping Chen; Musa A Hassan; Kenneth Hu; Christopher A Hunter; Ryan J Whitmarsh; jeroen saeij
Toxoplasma gondii Rhoptry 16 Kinase Promotes Host Resistance to Oral Infection and Intestinal Inflammation Only in the Context of the Dense Granule Protein GRA15.
Infection and immunity 2013;81(6):2156-67.
2013: Emily Gwyer Findlay; Christopher A Hunter; Colette A Inkson; Eleanor M Riley; Christiaan J Saris; Tovah N Shaw; Ana Villegas; J Brian de Souza; Kevin N Couper
IL-27 receptor signaling regulates CD4+ T cell chemotactic responses during infection.
Journal of immunology (Baltimore, Md. : 1950) 2013;190(9):4553-61.
2013: Ana Villegas; J Brian de Souza; Emily Gwyer Findlay; Christopher A Hunter; Seen-Wai Lavelle; Eleanor M Riley; Christiaan J Saris; Tovah N Shaw; Nico van Rooijen; Kevin N Couper
IL-27 receptor signalling restricts the formation of pathogenic, terminally differentiated Th1 cells during malaria infection by repressing IL-12 dependent signals.
PLoS pathogens 2013;9(4):e1003293.
2013: Melanie G Millholland; Satish Mishra; Bhumit Patel; Dustin Shilling; Photini Sinnis; Christopher D Dupont; J Kevin Foskett; Christopher A Hunter; Marcelo G Kazanietz; Melissa S Love; Doron C Greenbaum
A host GPCR signaling network required for the cytolysis of infected cells facilitates release of apicomplexan parasites.
Cell host & microbe 2013;13(1):15-28.
2012: Christopher A Hunter; Rob Kastelein
Interleukin-27: balancing protective and pathological immunity.
Immunity 2012;37(6):960-9.
2012: Christopher A Hunter; L David Sibley
Modulation of innate immunity by Toxoplasma gondii virulence effectors.
Nature reviews. Microbiology 2012;10(11):766-78.
2012: Christopher D Dupont; David A Christian; Christopher A Hunter
Immune response and immunopathology during toxoplasmosis.
Seminars in immunopathology 2012;34(6):793-813.
2012: Arielle Glatman Zaretsky; Jonathan S Silver; Marie Siwicki; Carl F Ware; Amy Durham; Christopher A Hunter
Infection with Toxoplasma gondii alters lymphotoxin expression associated with changes in splenic architecture.
Infection and immunity 2012;80(10):3602-10.
2012: Aisling O'Hara Hall; Tajie Harris; Daniel P Beiting; Yasmine Belkaid; Nicolas Bouladoux; Sara Cherry; Daniel J Cua; M Merle Elloso; John Grainger; Beena John; Claudia Gonzalez Lombana; Guillaume Oldenhove; Gretchen Harms Pritchard; Steven L Reiner; David S Roos; Philip Scott; Jonathan S Silver; Jason S Stumhofer; Cristina M Tato; Laurence A Turka; Sagie Wagage; Elia D Tait Wojno; Christopher A Hunter
The cytokines interleukin 27 and interferon-γ promote distinct Treg cell populations required to limit infection-induced pathology.
Immunity 2012;37(3):511-23.
2012: Christopher D Dupont; Christopher A Hunter
Guanylate-binding proteins: niche recruiters for antimicrobial effectors.
Immunity 2012;37(2):191-3.
2012: Ana Villegas; Daniel G Blount; J Brian de Souza; Rachel Greig; Emily Gwyer Findlay; Julius Hafalla; Christopher A Hunter; Eleanor M Riley; Tovah N Shaw; Jason S Stumhofer; Kevin N Couper
IFN-γ-producing CD4+ T cells promote experimental cerebral malaria by modulating CD8+ T cell accumulation within the brain.
Journal of immunology (Baltimore, Md. : 1950) 2012;189(2):968-79.
2012: Tajie Harris; Edward J Banigan; David A Christian; Beena John; Christoph Konradt; Andrea J Liu; Andrew D Luster; Kazumi Norose; Elia D Tait Wojno; Wolfgang Weninger; Emma H Wilson; Christopher A Hunter
Generalized Lévy walks and the role of chemokines in migration of effector CD8+ T cells.
Nature 2012;486(7404):545-8.
2012: David A Christian; Christopher A Hunter
Particle-mediated delivery of cytokines for immunotherapy.
Immunotherapy 2012;4(4):425-41.
2012: Elia D Tait Wojno; Christopher A Hunter
New directions in the basic and translational biology of interleukin-27.
Trends in immunology 2012;33(2):91-7.
2012: Karla R Wiehagen; Edward E Morrisey; Elizabeth S Staub; Evann Corbo-Rodgers; Christopher A Hunter; Shanru Li; Jonathan S Maltzman
Foxp4 is dispensable for T cell development, but required for robust recall responses.
PloS one 2012;7(8):e42273.
2012: Anita A Koshy; Jason H Melehani; Anjali J Shastri; David A Christian; Hans K Dietrich; Christopher A Hunter; John C Boothroyd
Toxoplasma co-opts host cells it does not invade.
PLoS pathogens 2012;8(7):e1002825.
2011: Brendon G Ricart; Michael T Yang; Christopher S Chen; Christopher A Hunter; Daniel A Hammer
Measuring traction forces of motile dendritic cells on micropost arrays.
Biophysical journal 2011;101(11):2620-8.
2011: Lauren H Sansing; Frank A Welsh; Tajie H Harris; Christopher A Hunter; Scott E Kasner; Katalin Kariko
Toll-like receptor 4 contributes to poor outcome after intracerebral hemorrhage.
Annals of neurology 2011;70(4):646-56.
2011: Ryan J Whitmarsh; Michael J May; Peter J Murray; David A Christian; Carolyn M Gray; Beth Gregg; Christopher A Hunter
A critical role for SOCS3 in innate resistance to Toxoplasma gondii.
Cell host & microbe 2011;10(3):224-36.
2011: Beena John; Louise M Randall; Brendon Ricart; Elia D Tait Wojno; Wolfgang Weninger; David A Christian; Daniel Manzoni De Almeida; Beth Gregg; Daniel A Hammer; Tajie Harris; Christopher A Hunter
Analysis of behavior and trafficking of dendritic cells within the brain during toxoplasmic encephalitis.
PLoS pathogens 2011;7(9):e1002246.
2011: Radhika Goenka; Christopher A Hunter; Lisa G Barnett; Michael P Cancro; Patrick J O'Neill; Jonathan S Silver; Tom Li Stephen
Cutting edge: dendritic cell-restricted antigen presentation initiates the follicular helper T cell program but cannot complete ultimate effector differentiation.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(3):1091-5.
2011: Elia D Tait Wojno; Qun Fang; Nancy Hosken; Steven D Levin; Elizabeth Mauldin; Aisling C O'Hara; Jason S Stumhofer; Laurence A Turka; Christopher A Hunter
A role for IL-27 in limiting T regulatory cell populations.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(1):266-73.
2011: Jonathan S Silver; Jason S Stumhofer; Matthias Ernst; Sara Passos; Christopher A Hunter
IL-6 mediates the susceptibility of glycoprotein 130 hypermorphs to Toxoplasma gondii.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(1):350-60.
2011: Kirk D C Jensen; Yi-Ching Ong; Anjali J Shastri; Yiding Wang; Elia D Tait Wojno; Erwan Boedec; John C Boothroyd; Yueh-hsiu Chien; Lara Cornel; Kenneth Hu; Christopher A Hunter; jeroen saeij
Toxoplasma polymorphic effectors determine macrophage polarization and intestinal inflammation.
Cell host & microbe 2011;9(6):472-83.
2011: Lillian R Aronson; Jason S Stumhofer; Kenneth J Drobatz; Christopher A Hunter
Effect of cyclosporine, dexamethasone, and human CTLA4-Ig on production of cytokines in lymphocytes of clinically normal cats and cats undergoing renal transplantation.
American journal of veterinary research 2011;72(4):541-9.
2011: Beth Gregg; Christopher A Hunter; Kimberly A Jordan; Florence Dzierszinski; Elia Tait; David S Roos
Subcellular antigen location influences T-cell activation during acute infection with Toxoplasma gondii.
PloS one 2011;6(7):e22936.
2011: Lauren H Sansing; Scott E Kasner; Tajie H Harris; Christopher A Hunter; Katalin Kariko
Neutrophil depletion diminishes monocyte infiltration and improves functional outcome after experimental intracerebral hemorrhage.
Acta neurochirurgica. Supplement 2011;111():173-8.
2011: Gareth W Jones; Jason S Stumhofer; Tom Foster; Jason P Twohig; Paul Hertzog; Nicholas Topley; Anwen Sian Williams; Christopher A Hunter; Brendan J Jenkins; Eddie C Y Wang; Simon A Jones
Naive and activated T cells display differential responsiveness to TL1A that affects Th17 generation, maintenance, and proliferation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2011;25(1):409-19.
2010: Jason S Stumhofer; Elia D Tait; William J Quinn; Nancy Hosken; Björn Spudy; Radhika Goenka; Ceri Fielding; Aisling C O'Hara; Yi Chen; Michael L Jones; Christiaan J M Saris; Stefan Rose-John; Daniel J Cua; Simon A Jones; MM Elloso; Joachim Grötzinger; Michael P Cancro; Steven D Levin; Christopher A Hunter
A role for IL-27p28 as an antagonist of gp130-mediated signaling.
Nature immunology 2010;11(12):1119-26.
2010: J S Silver; Christopher A Hunter
gp130 at the nexus of inflammation, autoimmunity, and cancer.
Journal of leukocyte biology 2010;88(6):1145-56.
2010: Kimberly A Jordan; Christopher D Dupont; Elia D Tait; Hsiou-Chi Liou; Christopher A Hunter
Role of the NF-κB transcription factor c-Rel in the generation of CD8+ T-cell responses to Toxoplasma gondii.
International immunology 2010;22(11):851-61.
2010: Kimberly A Jordan; Christopher A Hunter
Regulation of CD8+ T cell responses to infection with parasitic protozoa.
Experimental parasitology 2010;126(3):318-25.
2010: Beena John; Wolfgang Weninger; Christopher A Hunter
Advances in imaging the innate and adaptive immune response to Toxoplasma gondii.
Future microbiology 2010;5(9):1321-8.
2010: Emily Gwyer Findlay; Rachel Greig; Jason S Stumhofer; Julius Hafalla; J Brian de Souza; Christiaan J Saris; Christopher A Hunter; Eleanor M Riley; Kevin N Couper
Essential role for IL-27 receptor signaling in prevention of Th1-mediated immunopathology during malaria infection.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(4):2482-92.
2010: Elia D Tait; Kimberly A Jordan; Christopher D Dupont; Tajie H Harris; Beth Gregg; Emma H Wilson; Marion Pepper; Florence Dzierszinski; David S Roos; Christopher A Hunter
Virulence of Toxoplasma gondii is associated with distinct dendritic cell responses and reduced numbers of activated CD8+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(3):1502-12.
2010: Tajie Harris; Emma H Wilson; Elia D Tait; Marie Buckley; Sagi Shapira; Jorge Caamano; David Artis; Christopher A Hunter
NF-kappaB1 contributes to T cell-mediated control of Toxoplasma gondii in the CNS.
Journal of neuroimmunology 2010;222(1-2):19-28.
2010: Sara T Passos; Jonathan S Silver; Aisling C O'Hara; David Sehy; Jason S Stumhofer; Christopher A Hunter
IL-6 promotes NK cell production of IL-17 during toxoplasmosis.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(4):1776-83.
2009: Charles F Anderson; Jason S Stumhofer; Christopher A Hunter; David Sacks
IL-27 regulates IL-10 and IL-17 from CD4+ cells in nonhealing Leishmania major infection.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(7):4619-27.
2009: Kimberly A Jordan; Emma H Wilson; Elia D Tait; Barbara A Fox; David S Roos; David J Bzik; Florence Dzierszinski; Christopher A Hunter
Kinetics and phenotype of vaccine-induced CD8+ T-cell responses to Toxoplasma gondii.
Infection and immunity 2009;77(9):3894-901.
2009: Amy E Troy; Colby Zaph; Yurong Du; Betsy C Taylor; Katherine J Guild; Christopher A Hunter; Christiaan J M Saris; David Artis
IL-27 regulates homeostasis of the intestinal CD4+ effector T cell pool and limits intestinal inflammation in a murine model of colitis.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(3):2037-44.
2009: Beena John; Tajie Harris; Elia D Tait; Emma H Wilson; Beth Gregg; Lai Guan Ng; Paul Mrass; David S Roos; Florence Dzierszinski; Wolfgang Weninger; Christopher A Hunter
Dynamic Imaging of CD8(+) T cells and dendritic cells during infection with Toxoplasma gondii.
PLoS pathogens 2009;5(7):e1000505.
2009: Caroline Diveu; Mandy J McGeachy; Katia Boniface; Jason S Stumhofer; Manjiri Sathe; Barbara Joyce-Shaikh; Yi Chen; Cristina M Tato; Terrill McClanahan; Rene de Waal Malefyt; Christopher A Hunter; Daniel J Cua; Robert A Kastelein
IL-27 blocks RORc expression to inhibit lineage commitment of Th17 cells.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(9):5748-56.
2009: Elia D Tait; Christopher A Hunter
Advances in understanding immunity to Toxoplasma gondii.
Memórias do Instituto Oswaldo Cruz 2009;104(2):201-10.
2009: Emma H Wilson; Tajie Harris; Paul Mrass; Beena John; Elia D Tait; Gregory F Wu; Marion Pepper; E John Wherry; Florence Dzierzinski; David Roos; Philip G Haydon; Tom Li Stephen; Wolfgang Weninger; Christopher A Hunter
Behavior of parasite-specific effector CD8+ T cells in the brain and visualization of a kinesis-associated system of reticular fibers.
Immunity 2009;30(2):300-11.
2008: Christopher A Hunter; Robert Kastelein
New paradigms in inflammation: where to next?
Immunological reviews 2008;226():6-9.
2008: Emma H Wilson; Christopher A Hunter
Immunodominance and recognition of intracellular pathogens.
The Journal of infectious diseases 2008;198(11):1579-81.
2008: Ryan J Whitmarsh; Christopher A Hunter
Digest this! A role for autophagy in controlling pathogens.
Cell host & microbe 2008;4(5):413-4.
2008: E Sweeney; M Campbell; K Watkins; Christopher A Hunter; Olena Jacenko
Altered endochondral ossification in collagen X mouse models leads to impaired immune responses.
Developmental dynamics : an official publication of the American Association of Anatomists 2008;237(10):2693-704.
2008: Beena John; Christopher A Hunter
Immunology. Neutrophil soldiers or Trojan Horses?
Science (New York, N.Y.) 2008;321(5891):917-8.
2008: Andrew M Intlekofer; Arnob Banerjee; Naofumi Takemoto; Scott M Gordon; Caitlin S Dejong; Haina Shin; Christopher A Hunter; E John Wherry; Tullia Lindsten; Steven L Reiner
Anomalous type 17 response to viral infection by CD8+ T cells lacking T-bet and eomesodermin.
Science (New York, N.Y.) 2008;321(5887):408-11.
2008: Jonathan S Silver; Christopher A Hunter
With a little help from their friends: interleukin-21, T cells, and B cells.
Immunity 2008;29(1):7-9.
2008: Alejandro V Villarino; David Artis; Jelena S Bezbradica; Omer Miller; Christiaan J M Saris; Sebastian JOYCE; Christopher A Hunter
IL-27R deficiency delays the onset of colitis and protects from helminth-induced pathology in a model of chronic IBD.
International immunology 2008;20(6):739-52.
2008: Jason S Stumhofer; Christopher A Hunter
Advances in understanding the anti-inflammatory properties of IL-27.
Immunology letters 2008;117(2):123-30.
2008: Marion Pepper; Florence Dzierszinski; Emma Wilson; Elia Tait; Qun Fang; Felix Yarovinsky; Tom Li Stephen; David Roos; Christopher A Hunter
Plasmacytoid dendritic cells are activated by Toxoplasma gondii to present antigen and produce cytokines.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(9):6229-36.
2008: David F Larosa; Jason S Stumhofer; Andrew E Gelman; Adeeb Rahman; D K Taylor; Christopher A Hunter; Laurence A Turka
T cell expression of MyD88 is required for resistance to Toxoplasma gondii.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(10):3855-60.
2007: Jason S Stumhofer; J Silver; Christopher A Hunter
Negative regulation of Th17 responses.
Seminars in immunology 2007;19(6):394-9.
2007: Jason S Stumhofer; Jonathan S Silver; Arian Dominic John laurence; Paige M Porrett; Tajie Harris; Laurence A Turka; Matthias Ernst; Christiaan J M Saris; John O'Shea; Christopher A Hunter
Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10.
Nature immunology 2007;8(12):1363-71.
2007: Katherine S Masek; P Zhu; Bruce D Freedman; Christopher A Hunter
Toxoplasma gondii induces changes in intracellular calcium in macrophages.
Parasitology 2007;134(Pt.14):1973-9.
2007: Florence Dzierszinski; Marion Pepper; Jason S Stumhofer; David F Larosa; Emma H Wilson; Laurence A Turka; Sandra K Halonen; Christopher A Hunter; David S Roos
Presentation of Toxoplasma gondii antigens via the endogenous major histocompatibility complex class I pathway in nonprofessional and professional antigen-presenting cells.
Infection and immunity 2007;75(11):5200-9.
2007: Alejandro V Villarino; Cristina M Tato; Jason S Stumhofer; Zhengju Yao; Yongzhi K Cui; Lothar Hennighausen; John O'Shea; Christopher A Hunter
Helper T cell IL-2 production is limited by negative feedback and STAT-dependent cytokine signals.
The Journal of experimental medicine 2007;204(1):65-71.
2007: Robert A Kastelein; Christopher A Hunter; Daniel J Cua
Discovery and biology of IL-23 and IL-27: related but functionally distinct regulators of inflammation.
Annual review of immunology 2007;25():221-42.
2006: Katherine S Masek; Jim Fiore; Michael Leitges; Shi-Fang Yan; Bruce D Freedman; Christopher A Hunter
Host cell Ca2+ and protein kinase C regulate innate recognition of Toxoplasma gondii.
Journal of cell science 2006;119(Pt 21):4565-73.
2006: Jason S Stumhofer; Arian Dominic John laurence; Emma H Wilson; Elaine Huang; Cristina M Tato; Leanne M Johnson; Alejandro V Villarino; Qiulong Huang; Akihiko Yoshimura; David Sehy; Christiaan J M Saris; John O'Shea; Lothar Hennighausen; Matthias Ernst; Christopher A Hunter
Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system.
Nature immunology 2006;7(9):937-45.
2006: Emma H Wilson; Colby Zaph; Markus Mohrs; Andy Welcher; Jerry Siu; David Artis; Christopher A Hunter
B7RP-1-ICOS interactions are required for optimal infection-induced expansion of CD4+ Th1 and Th2 responses.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(4):2365-72.
2006: Yi Chen; Claire L Langrish; Brent S McKenzie; Barbara Joyce-Shaikh; Jason S Stumhofer; Terrill McClanahan; Wendy M Blumenschein; Tatyana Churakovsa; Justin Low; Leonard Presta; Christopher A Hunter; Robert A Kastelein; Daniel J Cua
Anti-IL-23 therapy inhibits multiple inflammatory pathways and ameliorates autoimmune encephalomyelitis.
The Journal of clinical investigation 2006;116(5):1317-26.
2006: Alexander M Owyang; Colby Zaph; Emma H Wilson; Katherine J Guild; Terrill McClanahan; Hugh Miller; Daniel J Cua; Michael H Goldschmidt; Christopher A Hunter; Robert A Kastelein; David Artis
Interleukin 25 regulates type 2 cytokine-dependent immunity and limits chronic inflammation in the gastrointestinal tract.
The Journal of experimental medicine 2006;203(4):843-9.
2006: Cristina M Tato; Nicola Mason; David Artis; Sagi Shapira; Jorge Caamano; Jay H Bream; Hsiou-Chi Liou; Christopher A Hunter
Opposing roles of NF-kappaB family members in the regulation of NK cell proliferation and production of IFN-gamma.
International immunology 2006;18(4):505-13.
2006: Alejandro V Villarino; Jason S Stumhofer; Christiaan J M Saris; Robert A Kastelein; Frederic J de Sauvage; Christopher A Hunter
IL-27 limits IL-2 production during Th1 differentiation.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(1):237-47.
2005: Sagi Shapira; Omar S Harb; Juan Margarit; Mariana Matrajt; Jerry Han; Alexander Hoffmann; Bruce Freedman; Michael May; David S Roos; Christopher A Hunter
Initiation and termination of NF-kappaB signaling by the intracellular protozoan parasite Toxoplasma gondii.
Journal of cell science 2005;118(Pt 15):3501-8.
2005: Emma H Wilson; Ulrike Wille-Reece; Florence Dzierszinski; Christopher A Hunter
A critical role for IL-10 in limiting inflammation during toxoplasmic encephalitis.
Journal of neuroimmunology 2005;165(1-2):63-74.
2005: Christopher A Hunter
New IL-12-family members: IL-23 and IL-27, cytokines with divergent functions.
Nature reviews. Immunology 2005;5(7):521-31.
2005: Alejandro V Villarino; Joseph Larkin; Christiaan J M Saris; Andrew J Caton; Sophie Lucas; Terence Wong; Frederic J de Sauvage; Christopher A Hunter
Positive and negative regulation of the IL-27 receptor during lymphoid cell activation.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(12):7684-91.
2005: Lillian R Aronson; Kenneth J Drobatz; Christopher A Hunter; Nicola Mason
Effects of CD28 blockade on subsets of naïve T cells in cats.
American journal of veterinary research 2005;66(3):483-92.
2005: Jie Sun; Matthew Walsh; Alejandro V Villarino; Laura Cervi; Christopher A Hunter; Yongwon Choi; Edward J Pearce
TLR ligands can activate dendritic cells to provide a MyD88-dependent negative signal for Th2 cell development.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(2):742-51.
2004: Colleen M Kane; Laura Cervi; Jie Sun; Amy S McKee; Katherine S Masek; Sagi Shapira; Christopher A Hunter; Edward J Pearce
Helminth antigens modulate TLR-initiated dendritic cell activation.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(12):7454-61.
2004: Marion Pepper; Florence Dzierszinski; Amy Crawford; Christopher A Hunter; David Roos
Development of a system to study CD4+-T-cell responses to transgenic ovalbumin-expressing Toxoplasma gondii during toxoplasmosis.
Infection and immunity 2004;72(12):7240-6.
2004: Christopher A Hunter; Alejandro V Villarino; David Artis; Phillip Scott
The role of IL-27 in the development of T-cell responses during parasitic infections.
Immunological reviews 2004;202():106-14.
2004: Linda A Lieberman; Eric Villegas; Christopher A Hunter
Interleukin-15-deficient mice develop protective immunity to Toxoplasma gondii.
Infection and immunity 2004;72(11):6729-32.
2004: David Artis; Alejandro V Villarino; Michael Silverman; Weimian He; Elisabeth M Thornton; Sharon Mu; Shamin Summer; Todd M Covey; Elaine Huang; Hiroki Yoshida; Gary A Koretzky; Michael H Goldschmidt; Gary D Wu; Frederic J de Sauvage; Hugh Miller; Christiaan J M Saris; Phillip Scott; Christopher A Hunter
The IL-27 receptor (WSX-1) is an inhibitor of innate and adaptive elements of type 2 immunity.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(9):5626-34.
2004: Nicola Mason; Jim Fiore; Takashi Kobayashi; Katherine S Masek; Yongwon Choi; Christopher A Hunter
TRAF6-dependent mitogen-activated protein kinase activation differentially regulates the production of interleukin-12 by macrophages in response to Toxoplasma gondii.
Infection and immunity 2004;72(10):5662-7.
2004: Nicola Mason; David Artis; Christopher A Hunter
New lessons from old pathogens: what parasitic infections have taught us about the role of nuclear factor-kappaB in the regulation of immunity.
Immunological reviews 2004;201():48-56.
2004: Linda A Lieberman; Fabiola Cardillo; Alexander M Owyang; Donna Rennick; Daniel J Cua; Robert A Kastelein; Christopher A Hunter
IL-23 provides a limited mechanism of resistance to acute toxoplasmosis in the absence of IL-12.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(3):1887-93.
2004: Cristina M Tato; Gislaine Martins; Frances A High; Catherine B DiCioccio; Steven L Reiner; Christopher A Hunter
Cutting Edge: Innate production of IFN-gamma by NK cells is independent of epigenetic modification of the IFN-gamma promoter.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(3):1514-7.
2004: Alejandro V Villarino; Elaine Huang; Christopher A Hunter
Understanding the pro- and anti-inflammatory properties of IL-27.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(2):715-20.
2004: Ulrike Wille; Manami Nishi; Linda A Lieberman; Emma H Wilson; David S Roos; Christopher A Hunter
IL-10 is not required to prevent immune hyperactivity during memory responses to Toxoplasma gondii.
Parasite immunology 2004;26(5):229-36.
2004: Sarah L Sague; Cristina M Tato; Ellen Puré; Christopher A Hunter
The regulation and activation of CD44 by natural killer (NK) cells and its role in the production of IFN-gamma.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2004;24(5):301-9.
2004: David Artis; Leanne M Johnson; Karen Joyce; Christiaan J M Saris; Alejandro V Villarino; Christopher A Hunter; Phillip Scott
Cutting edge: early IL-4 production governs the requirement for IL-27-WSX-1 signaling in the development of protective Th1 cytokine responses following Leishmania major infection.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(8):4672-5.
2004: Emma H Wilson; Christopher A Hunter
The role of astrocytes in the immunopathogenesis of toxoplasmic encephalitis.
International journal for parasitology 2004;34(5):543-8.
2004: Nicola Mason; Hsiou-Chi Liou; Christopher A Hunter
T cell-intrinsic expression of c-Rel regulates Th1 cell responses essential for resistance to Toxoplasma gondii.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(6):3704-11.
2004: Sagi Shapira; Omar S Harb; Jorge Caamano; Christopher A Hunter
The NF-kappaB signaling pathway: immune evasion and immunoregulation during toxoplasmosis.
International journal for parasitology 2004;34(3):393-400.
2004: Kendra Speirs; Linda A Lieberman; Jorge Caamano; Christopher A Hunter; Phillip Scott
Cutting edge: NF-kappa B2 is a negative regulator of dendritic cell function.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(2):752-6.
2004: Alejandro V Villarino; Christopher A Hunter
Biology of recently discovered cytokines: discerning the pro- and anti-inflammatory properties of interleukin-27.
Arthritis research & therapy 2004;6(5):225-33.
2004: Linda A Lieberman; Monica Banica; Steven L Reiner; Christopher A Hunter
STAT1 plays a critical role in the regulation of antimicrobial effector mechanisms, but not in the development of Th1-type responses during toxoplasmosis.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(1):457-63.
2003: Erika L Pearce; Alan C Mullen; Gislaine Martins; Connie M Krawczyk; Anne S Hutchins; Valerie P Zediak; Monica Banica; Catherine B DiCioccio; Darrick A Gross; Chai-An Mao; Hao Shen; Nezih Cereb; Soo Y Yang; Tullia Lindsten; Janet Rossant; Christopher A Hunter; Steven L Reiner
Control of effector CD8+ T cell function by the transcription factor Eomesodermin.
Science (New York, N.Y.) 2003;302(5647):1041-3.
2003: Erinn B Rankin; Duonan Yu; Jiu Jiang; Hao Shen; Edward J Pearce; Michael H Goldschmidt; David E Levy; Tatyana V Golovkina; Christopher A Hunter; Andrei Thomas-Tikhonenko
An essential role of Th1 responses and interferon gamma in infection-mediated suppression of neoplastic growth.
Cancer biology & therapy 2003;2(6):687-93.
2003: Alejandro V Villarino; Linda Hibbert; Linda A Lieberman; Emma Wilson; Tak Mak; Hiroki Yoshida; Robert A Kastelein; Christiaan J M Saris; Christopher A Hunter
The IL-27R (WSX-1) is required to suppress T cell hyperactivity during infection.
Immunity 2003;19(5):645-55.
2003: Emma H Wilson; Christopher A Hunter
Understanding the role of the CD40--CD40L interaction in resistance to parasitic infections.
Parasite immunology 2003;25(4):179-83.
2003: Cristina M Tato; Alejandro V Villarino; Jorge Caamaño; Mark Boothby; Christopher A Hunter
Inhibition of NF-kappa B activity in T and NK cells results in defective effector cell expansion and production of IFN-gamma required for resistance to Toxoplasma gondii.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(6):3139-46.
2003: David Artis; Kendra Speirs; Karen Joyce; Michael H Goldschmidt; Jorge Caamaño; Christopher A Hunter; Phillip Scott
NF-kappa B1 is required for optimal CD4+ Th1 cell development and resistance to Leishmania major.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(4):1995-2003.
2003: Andrei Thomas-Tikhonenko; Christopher A Hunter
Infection and cancer: the common vein.
Cytokine & growth factor reviews 2003;14(1):67-77.
2003: Valerie P Zediak; Christopher A Hunter
IL-10 fails to inhibit the production of IL-18 in response to inflammatory stimuli.
Cytokine 2003;21(2):84-90.
2003: Christopher A Hunter; Linda A Lieberman; Nicola Mason; Marion Pepper; Sarah L Sague; Cristina M Tato; Valerie P Zediak
Costimulation in resistance to infection and development of immune pathology: lessons from toxoplasma.
Immunologic research 2003;27(2-3):331-40.
2002: Linda A Lieberman; Christopher A Hunter
Regulatory pathways involved in the infection-induced production of IFN-gamma by NK cells.
Microbes and infection / Institut Pasteur 2002;4(15):1531-8.
2002: Ulrike Wille; Eric Villegas; Linden Craig; Robert Peach; Christopher A Hunter
Contribution of interleukin-12 (IL-12) and the CD28/B7 and CD40/CD40 ligand pathways to the development of a pathological T-cell response in IL-10-deficient mice.
Infection and immunity 2002;70(12):6940-7.
2002: David Artis; Sagi Shapira; Nicola Mason; Kendra Speirs; Michael H Goldschmidt; Jorge Caamaño; Hsiou-Chi Liou; Christopher A Hunter; Phillip Scott
Differential requirement for NF-kappa B family members in control of helminth infection and intestinal inflammation.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(8):4481-7.
2002: Lei Zhao; Carolyn A Cuff; Erin Moss; Ulrike Wille; Tillmann Cyrus; Eric A Klein; Domenico Pratico'; Daniel J Rader; Christopher A Hunter; Ellen Puré; Colin D Funk
Selective interleukin-12 synthesis defect in 12/15-lipoxygenase-deficient macrophages associated with reduced atherosclerosis in a mouse model of familial hypercholesterolemia.
The Journal of biological chemistry 2002;277(38):35350-6.
2002: Eric Villegas; Linda A Lieberman; Simon R Carding; Christopher A Hunter
Susceptibility of interleukin-2-deficient mice to Toxoplasma gondii is associated with a defect in the production of gamma interferon.
Infection and immunity 2002;70(9):4757-61.
2002: Phillip Scott; Christopher A Hunter
Dendritic cells and immunity to leishmaniasis and toxoplasmosis.
Current opinion in immunology 2002;14(4):466-70.
2002: Eric Villegas; Linda A Lieberman; Nicola Mason; Sarah L Blass; Valerie P Zediak; Robert Peach; Tom Horan; Steven K Yoshinaga; Christopher A Hunter
A role for inducible costimulator protein in the CD28- independent mechanism of resistance to Toxoplasma gondii.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(2):937-43.
2002: Linda A Lieberman; Christopher A Hunter
The role of cytokines and their signaling pathways in the regulation of immunity to Toxoplasma gondii.
International reviews of immunology 2002;21(4-5):373-403.
2002: Jorge Caamaño; Christopher A Hunter
NF-kappaB family of transcription factors: central regulators of innate and adaptive immune functions.
Clinical microbiology reviews 2002;15(3):414-29.
2002: Cristina M Tato; Christopher A Hunter
Host-pathogen interactions: subversion and utilization of the NF-kappa B pathway during infection.
Infection and immunity 2002;70(7):3311-7.
2002: Kendra Speirs; Jorge Caamano; Michael H Goldschmidt; Christopher A Hunter; Phillip Scott
NF-kappa B2 is required for optimal CD40-induced IL-12 production but dispensable for Th1 cell Differentiation.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(9):4406-13.
2002: Nicola Mason; Julio Aliberti; Jorge Caamano; Hsiou-Chi Liou; Christopher A Hunter
Cutting edge: identification of c-Rel-dependent and -independent pathways of IL-12 production during infectious and inflammatory stimuli.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(6):2590-4.
2002: Sagi Shapira; Kendra Speirs; A Gerstein; Jorge Caamano; Christopher A Hunter
Suppression of NF-kappaB activation by infection with Toxoplasma gondii.
The Journal of infectious diseases 2002;185 Suppl 1():S66-72.
2001: M L Murphy; Ulrike Wille; Eric Villegas; Christopher A Hunter; Jay P Farrell
IL-10 mediates susceptibility to Leishmania donovani infection.
European journal of immunology 2001;31(10):2848-56.
2001: Ulrike Wille; Eric Villegas; Boris Striepen; David S Roos; Christopher A Hunter
Interleukin-10 does not contribute to the pathogenesis of a virulent strain of Toxoplasma gondii.
Parasite immunology 2001;23(6):291-6.
2001: Christopher A Hunter; Duonan Yu; Michael S Gee; CV Ngo; Cinzia Sevignani; Michael H Goldschmidt; Tatyana V Golovkina; S Evans; W F Lee; Andrei Thomas-Tikhonenko
Cutting edge: systemic inhibition of angiogenesis underlies resistance to tumors during acute toxoplasmosis.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(10):5878-81.
2001: S L Blass; Ellen Puré; Christopher A Hunter
A role for CD44 in the production of IFN-gamma and immunopathology during infection with Toxoplasma gondii.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(9):5726-32.
2000: G Cai; Robert A Kastelein; Christopher A Hunter
Interleukin-18 (IL-18) enhances innate IL-12-mediated resistance to Toxoplasma gondii.
Infection and immunity 2000;68(12):6932-8.
2000: Jorge Caamaño; C Tato; G Cai; Eric Villegas; Kendra Speirs; Linden Craig; James Alexander; Christopher A Hunter
Identification of a role for NF-kappa B2 in the regulation of apoptosis and in maintenance of T cell-mediated immunity to Toxoplasma gondii.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(10):5720-8.
2000: G Cai; T Radzanowski; Eric Villegas; Robert A Kastelein; Christopher A Hunter
Identification of STAT4-dependent and independent mechanisms of resistance to Toxoplasma gondii.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(5):2619-27.
2000: Christopher A Hunter; Steven L Reiner
Cytokines and T cells in host defense.
Current opinion in immunology 2000;12(4):413-8.
2000: Eric Villegas; Ulrike Wille; Linden Craig; Peter Linsley; Donna Rennick; Robert Peach; Christopher A Hunter
Blockade of costimulation prevents infection-induced immunopathology in interleukin-10-deficient mice.
Infection and immunity 2000;68(5):2837-44.
2000: G Reichmann; W Walker; Eric Villegas; Linden Craig; G Cai; James Alexander; Christopher A Hunter
The CD40/CD40 ligand interaction is required for resistance to toxoplasmic encephalitis.
Infection and immunity 2000;68(3):1312-8.
1999: Jorge Caamaño; James Alexander; Linden Craig; R Bravo; Christopher A Hunter
The NF-kappa B family member RelB is required for innate and adaptive immunity to Toxoplasma gondii.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(8):4453-61.
1999: G Reichmann; Eric Villegas; Linden Craig; Robert Peach; Christopher A Hunter
The CD28/B7 interaction is not required for resistance to Toxoplasma gondii in the brain but contributes to the development of immunopathology.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(6):3354-62.
1999: Eric Villegas; MM Elloso; G Reichmann; Robert Peach; Christopher A Hunter
Role of CD28 in the generation of effector and memory responses required for resistance to Toxoplasma gondii.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(6):3344-53.
1999: G Cai; Robert A Kastelein; Christopher A Hunter
IL-10 enhances NK cell proliferation, cytotoxicity and production of IFN-gamma when combined with IL-18.
European journal of immunology 1999;29(9):2658-65.
1999: W Walker; M Aste-Amezaga; Robert A Kastelein; Giorgio Trinchieri; Christopher A Hunter
IL-18 and CD28 use distinct molecular mechanisms to enhance NK cell production of IL-12-induced IFN-gamma.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(10):5894-901.
1999: J Li; Christopher A Hunter; Jay P Farrell
Anti-TGF-beta treatment promotes rapid healing of Leishmania major infection in mice by enhancing in vivo nitric oxide production.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(2):974-9.
1998: H K Koblish; Christopher A Hunter; Maria Wysocka; Giorgio Trinchieri; W M Lee
Immune suppression by recombinant interleukin (rIL)-12 involves interferon gamma induction of nitric oxide synthase 2 (iNOS) activity: inhibitors of NO generation reveal the extent of rIL-12 vaccine adjuvant effect.
The Journal of experimental medicine 1998;188(9):1603-10.
1998: Wolfgang Bohne; Christopher A Hunter; Michael W White; D J Ferguson; U Gross; David S Roos
Targeted disruption of the bradyzoite-specific gene BAG1 does not prevent tissue cyst formation in Toxoplasma gondii.
Molecular and biochemical parasitology 1998;92(2):291-301.
1998: Christina M Coughlin; KE Salhany; Maria Wysocka; E Aruga; H Kurzawa; Alfred E Chang; Christopher A Hunter; J C Fox; Giorgio Trinchieri; William M F Lee
Interleukin-12 and interleukin-18 synergistically induce murine tumor regression which involves inhibition of angiogenesis.
The Journal of clinical investigation 1998;101(6):1441-52.
1997: Christopher A Hunter; Jacqueline Timans; P Pisacane; Satish Menon; G Cai; W Walker; M Aste-Amezaga; R Chizzonite; J. Fernando Bazan; Robert A Kastelein
Comparison of the effects of interleukin-1 alpha, interleukin-1 beta and interferon-gamma-inducing factor on the production of interferon-gamma by natural killer.
European journal of immunology 1997;27(11):2787-92.
1997: Christopher A Hunter; KE Gabriel; T Radzanowski; LE Neyer; Jack S Remington
Type I interferons enhance production of IFN-gamma by NK cells.
Immunology letters 1997;59(1):1-5.
1997: LE Neyer; Gabriele Grunig; MM Fort; Jack S Remington; Donna Rennick; Christopher A Hunter
Role of interleukin-10 in regulation of T-cell-dependent and T-cell-independent mechanisms of resistance to Toxoplasma gondii.
Infection and immunity 1997;65(5):1675-82.
1997: Christopher A Hunter; L A Ellis-Neyes; Teri Slifer; ST Kanaly; Gabriele Grünig; MM Fort; Donna Rennick; F G Araujo
IL-10 is required to prevent immune hyperactivity during infection with Trypanosoma cruzi.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(7):3311-6.
1997: Christopher A Hunter; L Ellis-Neyer; KE Gabriel; M K Kennedy; K H Grabstein; Peter Linsley; Jack S Remington
The role of the CD28/B7 interaction in the regulation of NK cell responses during infection with Toxoplasma gondii.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(5):2285-93.
1996: Christopher A Hunter
How are NK cell responses regulated during infection?
Experimental parasitology 1996;84(3):444-8.
1996: Christopher A Hunter; Teri Slifer; F Araujo
Interleukin-12-mediated resistance to Trypanosoma cruzi is dependent on tumor necrosis factor alpha and gamma interferon.
Infection and immunity 1996;64(7):2381-6.
1996: Christopher A Hunter; Yasuhiro Suzuki; Carlos S Subauste; Jack S Remington
Cells and cytokines in resistance to Toxoplasma gondii.
Current topics in microbiology and immunology 1996;219():113-25.
1995: Christopher A Hunter; R Chizzonite; Jack S Remington
IL-1 beta is required for IL-12 to induce production of IFN-gamma by NK cells. A role for IL-1 beta in the T cell-independent mechanism of resistance against intracellular pathogens.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(9):4347-54.
1995: Christopher A Hunter; Jack S Remington
The role of IL12 in toxoplasmosis.
Research in immunology 1995;146(7-8):546-52.
1995: Carlos S Subauste; J Y Chung; D Do; A H Koniaris; Christopher A Hunter; Jose G Montoya; Steven A Porcelli; Jack S Remington
Preferential activation and expansion of human peripheral blood gamma delta T cells in response to Toxoplasma gondii in vitro and their cytokine production and cytotoxic activity against T. gondii-infected cells.
The Journal of clinical investigation 1995;96(1):610-9.
1995: Christopher A Hunter; L Bermudez; H Beernink; W Waegell; Jack S Remington
Transforming growth factor-beta inhibits interleukin-12-induced production of interferon-gamma by natural killer cells: a role for transforming growth factor-beta in the regulation of T cell-independent resistance to Toxoplasma gondii.
European journal of immunology 1995;25(4):994-1000.
1995: E Candolfi; Christopher A Hunter; Jack S Remington
Roles of gamma interferon and other cytokines in suppression of the spleen cell proliferative response to concanavalin A and toxoplasma antigen during acute toxoplasmosis.
Infection and immunity 1995;63(3):751-6.
1995: Christopher A Hunter; E Candolfi; Carlos S Subauste; V Van Cleave; Jack S Remington
Studies on the role of interleukin-12 in acute murine toxoplasmosis.
Immunology 1995;84(1):16-20.
1994: M H Beaman; Christopher A Hunter; Jack S Remington
Enhancement of intracellular replication of Toxoplasma gondii by IL-6. Interactions with IFN-gamma and TNF-alpha.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(10):4583-7.
1994: Christopher A Hunter; Jack S Remington
Immunopathogenesis of toxoplasmic encephalitis.
The Journal of infectious diseases 1994;170(5):1057-67.
1994: Christopher A Hunter; M J Litton; Jack S Remington; J S Abrams
Immunocytochemical detection of cytokines in the lymph nodes and brains of mice resistant or susceptible to toxoplasmic encephalitis.
The Journal of infectious diseases 1994;170(4):939-45.
1994: Christopher A Hunter; Carlos S Subauste; V H Van Cleave; Jack S Remington
Production of gamma interferon by natural killer cells from Toxoplasma gondii-infected SCID mice: regulation by interleukin-10, interleukin-12, and tumor necrosis factor alpha.
Infection and immunity 1994;62(7):2818-24.
1994: E Candolfi; Christopher A Hunter; Jack S Remington
Mitogen- and antigen-specific proliferation of T cells in murine toxoplasmosis is inhibited by reactive nitrogen intermediates.
Infection and immunity 1994;62(5):1995-2001.
1994: Christopher A Hunter; Carlos S Subauste; Jack S Remington
The role of cytokines in toxoplasmosis.
Biotherapy (Dordrecht, Netherlands) 1994;7(3-4):237-47.
1993: Christopher A Hunter; J S Abrams; M H Beaman; Jack S Remington
Cytokine mRNA in the central nervous system of SCID mice infected with Toxoplasma gondii: importance of T-cell-independent regulation of resistance to T. gondii.
Infection and immunity 1993;61(10):4038-44.