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James Huntington

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Irene Martínez-Martínez; José Navarro-Fernández; Adriana Ordóñez; Vicente Vicente; M Yamasaki; James A Huntington; D J D Johnson; Javier Corral
Type II antithrombin deficiency caused by a large in-frame insertion: structural, functional and pathological relevance.
Wei Li; James A Huntington
Crystal structures of protease nexin-1 in complex with heparin and thrombin suggest a 2-step recognition mechanism.
Masayuki Yamasaki; Mary C Pearce; Timothy J Sendall; James C Whisstock; James A Huntington
Molecular basis of α1-antitrypsin deficiency revealed by the structure of a domain-swapped trimer.

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All Publications

2012: Irene Martínez-Martínez; José Navarro-Fernández; Adriana Ordóñez; Vicente Vicente; M Yamasaki; James A Huntington; D J D Johnson; Javier Corral
Type II antithrombin deficiency caused by a large in-frame insertion: structural, functional and pathological relevance.
Journal of thrombosis and haemostasis : JTH 2012;10(9):1859-66.
2012: Wei Li; James A Huntington
Crystal structures of protease nexin-1 in complex with heparin and thrombin suggest a 2-step recognition mechanism.
Blood 2012;120(2):459-67.
2011: Masayuki Yamasaki; Mary C Pearce; Timothy J Sendall; James C Whisstock; James A Huntington
Molecular basis of α1-antitrypsin deficiency revealed by the structure of a domain-swapped trimer.
EMBO reports 2011;12(10):1011-7.
2010: Wei Li; Daniel J D Johnson; Ty E Adams; Nicola Pozzi; Vincenzo De Filippis; James A Huntington
Thrombin inhibition by serpins disrupts exosite II.
The Journal of biological chemistry 2010;285(49):38621-9.
2010: Masayuki Yamasaki; Timothy J Sendall; Laura E Harris; Giles M W Lewis; James A Huntington
Loop-sheet mechanism of serpin polymerization tested by reactive center loop mutations.
The Journal of biological chemistry 2010;285(40):30752-8.
2010: Bernhard C Lechtenberg; Daniel J D Johnson; Stefan M V Freund; James A Huntington
NMR resonance assignments of thrombin reveal the conformational and dynamic effects of ligation.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(32):14087-92.
2010: James A Huntington; James C Whisstock
Molecular contortionism - on the physical limits of serpin 'loop-sheet' polymers.
Biological chemistry 2010;391(8):973-82.
2010: Daniel J D Johnson; Jonathan Langdown; James A Huntington
Molecular basis of factor IXa recognition by heparin-activated antithrombin revealed by a 1.7-A structure of the ternary complex.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(2):645-50.
2009: Ty E Adams; Wei Li; James A Huntington
Molecular basis of thrombomodulin activation of slow thrombin.
Journal of thrombosis and haemostasis : JTH 2009;7(10):1688-95.
2009: James A Huntington
Slow thrombin is zymogen-like.
Journal of thrombosis and haemostasis : JTH 2009;7 Suppl 1():159-64.
2009: Jonathan Langdown; Klara J Belzar; Wendy J Savory; Trevor P Baglin; James A Huntington
The critical role of hinge-region expulsion in the induced-fit heparin binding mechanism of antithrombin.
Journal of molecular biology 2009;386(5):1278-89.
2009: James A Huntington; Timothy J Sendall; Masayuki Yamasaki
New insight into serpin polymerization and aggregation.
Prion 2009;3(1):12-4.
2009: James A Huntington; Wei Li
Structural insights into the multiple functions of protein C inhibitor.
Cellular and molecular life sciences : CMLS 2009;66(1):113-21.
2008: Masayuki Yamasaki; Wei Li; Daniel J D Johnson; James A Huntington
Crystal structure of a stable dimer reveals the molecular basis of serpin polymerization.
Nature 2008;455(7217):1255-8.
2008: James A Huntington
How Na+ activates thrombin--a review of the functional and structural data.
Biological chemistry 2008;389(8):1025-35.
2008: Cedric Ghevaert; Alexandre Salsmann; Nicholas A Watkins; Elisabeth Schaffner-Reckinger; Angela Rankin; Stephen F Garner; Jonathan Stephens; Graham Smith; Najet Debili; William Vainchenker; Philip G de Groot; James A Huntington; Mike Laffan; NELLY KIEFFER; Willem H Ouwehand
A nonsynonymous SNP in the ITGB3 gene disrupts the conserved membrane-proximal cytoplasmic salt bridge in the alphaIIbbeta3 integrin and cosegregates dominantly with abnormal proplatelet formation and macrothrombocytopenia.
Blood 2008;111(7):3407-14.
2008: Wei Li; Ty E Adams; Jyoti Nangalia; Charles T Esmon; James A Huntington
Molecular basis of thrombin recognition by protein C inhibitor revealed by the 1.6-A structure of the heparin-bridged complex.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(12):4661-6.
2008: Prachi Stafford; Cedric Ghevaert; Kate Campbell; C Proulx; Graham Smith; Lorna M Williamson; Edmund Ranasinghe; Nicholas A Watkins; James A Huntington; Willem H Ouwehand
Immunologic and structural analysis of eight novel domain-deletion beta3 integrin peptides designed for detection of HPA-1 antibodies.
Journal of thrombosis and haemostasis : JTH 2008;6(2):366-75.
2007: J C Rau; Lea M Beaulieu; James A Huntington; Frank Church
Serpins in thrombosis, hemostasis and fibrinolysis.
Journal of thrombosis and haemostasis : JTH 2007;5 Suppl 1():102-15.
2007: Wei Li; Ty E Adams; Margareta Kjellberg; Johan Stenflo; James A Huntington
Structure of native protein C inhibitor provides insight into its multiple functions.
The Journal of biological chemistry 2007;282(18):13759-68.
2006: Daniel J D Johnson; Jonathan Langdown; Wei Li; Stephan A Luis; Trevor P Baglin; James A Huntington
Crystal structure of monomeric native antithrombin reveals a novel reactive center loop conformation.
The Journal of biological chemistry 2006;281(46):35478-86.
2006: Jonathan Langdown; Wendy J Carter; Trevor P Baglin; James A Huntington
Allosteric activation of antithrombin is independent of charge neutralization or reversal in the heparin binding site.
FEBS letters 2006;580(19):4709-12.
2006: James A Huntington
Shape-shifting serpins--advantages of a mobile mechanism.
Trends in biochemical sciences 2006;31(8):427-35.
2006: Ty E Adams; James A Huntington
Thrombin-cofactor interactions: structural insights into regulatory mechanisms.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(8):1738-45.
2006: Wei Li; Louise C Serpell; Wendy J Carter; David C Rubinsztein; James A Huntington
Expression and characterization of full-length human huntingtin, an elongated HEAT repeat protein.
The Journal of biological chemistry 2006;281(23):15916-22.
2006: Lynda K Sharp; Meera Mallya; Kerri Kinghorn; Zhen Wang; Damian C Crowther; James A Huntington; Didier Belorgey; David A Lomas
Sugar and alcohol molecules provide a therapeutic strategy for the serpinopathies that cause dementia and cirrhosis.
The FEBS journal 2006;273(11):2540-52.
2006: Daniel J D Johnson; Wei Li; Ty E Adams; James A Huntington
Antithrombin-S195A factor Xa-heparin structure reveals the allosteric mechanism of antithrombin activation.
The EMBO journal 2006;25(9):2029-37.
2005: Daniel J D Johnson; Ty E Adams; Wei Li; James A Huntington
Crystal structure of wild-type human thrombin in the Na+-free state.
The Biochemical journal 2005;392(Pt 1):21-8.
2005: James A Huntington
Slow thrombin in solution.
The Biochemical journal 2005;390(Pt 2):e1-3.
2005: James A Huntington
Molecular recognition mechanisms of thrombin.
Journal of thrombosis and haemostasis : JTH 2005;3(8):1861-72.
2005: Wendy J Carter; Evis Cama Hursever; James A Huntington
Crystal structure of thrombin bound to heparin.
The Journal of biological chemistry 2005;280(4):2745-9.
2004: Denis O'Keeffe; Steven T Olson; Nijole Gasiunas; John Gallagher; Trevor P Baglin; James A Huntington
The heparin binding properties of heparin cofactor II suggest an antithrombin-like activation mechanism.
The Journal of biological chemistry 2004;279(48):50267-73.
2004: Jonathan Langdown; Daniel J D Johnson; Trevor P Baglin; James A Huntington
Allosteric activation of antithrombin critically depends upon hinge region extension.
The Journal of biological chemistry 2004;279(45):47288-97.
2004: Aiwu Zhou; Penelope E Stein; James A Huntington; Pasupathy Sivasothy; David A Lomas; Robin W Carrell
How small peptides block and reverse serpin polymerisation.
Journal of molecular biology 2004;342(3):931-41.
2004: Javier Corral; Justo Aznar; Rocio Gonzalez-Conejero; Piedad Villa; Antonia Miñano; Amparo Vayá; Robin W Carrell; James A Huntington; Vicente Vicente
Homozygous deficiency of heparin cofactor II: relevance of P17 glutamate residue in serpins, relationship with conformational diseases, and role in thrombosis.
Circulation 2004;110(10):1303-7.
2004: Wei Li; Daniel J D Johnson; Charles T Esmon; James A Huntington
Structure of the antithrombin-thrombin-heparin ternary complex reveals the antithrombotic mechanism of heparin.
Nature structural & molecular biology 2004;11(9):857-62.
2004: Wendy J Carter; Timothy Myles; Craig S Gibbs; Lawrence L K Leung; James A Huntington
Crystal structure of anticoagulant thrombin variant E217K provides insights into thrombin allostery.
The Journal of biological chemistry 2004;279(25):26387-94.
2004: Javier Corral; James A Huntington; Rocio González-Conejero; Alec Mushunje; M Navarro; Pascual Marco; Vicente Vicente; Robin W Carrell
Mutations in the shutter region of antithrombin result in formation of disulfide-linked dimers and severe venous thrombosis.
Journal of thrombosis and haemostasis : JTH 2004;2(6):931-9.
2004: Daniel J D Johnson; James A Huntington
The influence of hinge region residue Glu-381 on antithrombin allostery and metastability.
The Journal of biological chemistry 2004;279(6):4913-21.
2003: Alec Mushunje; Aiwu Zhou; Robin W Carrell; James A Huntington
Heparin-induced substrate behavior of antithrombin Cambridge II.
Blood 2003;102(12):4028-34.
2003: James A Huntington; Trevor P Baglin
Targeting thrombin--rational drug design from natural mechanisms.
Trends in pharmacological sciences 2003;24(11):589-95.
2003: Daniel J D Johnson; James A Huntington
Crystal structure of antithrombin in a heparin-bound intermediate state.
Biochemistry 2003;42(29):8712-9.
2003: James A Huntington
Mechanisms of glycosaminoglycan activation of the serpins in hemostasis.
Journal of thrombosis and haemostasis : JTH 2003;1(7):1535-49.
2003: Aiwu Zhou; James A Huntington; Neesh Pannu; Robin W Carrell; Randy J Read
How vitronectin binds PAI-1 to modulate fibrinolysis and cell migration.
Nature structural biology 2003;10(7):541-4.
2003: Aiwu Zhou; Penelope E Stein; James A Huntington; Robin W Carrell
Serpin polymerization is prevented by a hydrogen bond network that is centered on his-334 and stabilized by glycerol.
The Journal of biological chemistry 2003;278(17):15116-22.
2003: James A Huntington; Charles T Esmon
The molecular basis of thrombin allostery revealed by a 1.8 A structure of the "slow" form.
Structure (London, England : 1993) 2003;11(4):469-79.
2003: James A Huntington; Margareta Kjellberg; Johan Stenflo
Crystal structure of protein C inhibitor provides insights into hormone binding and heparin activation.
Structure (London, England : 1993) 2003;11(2):205-15.
2003: Robin W Carrell; James A Huntington
How serpins change their fold for better and for worse.
Biochemical Society symposium 2003;(70):163-78.
2002: Alec Mushunje; Aiwu Zhou; James A Huntington; Jacqueline Conard; Robin W Carrell
Antithrombin 'DREUX' (Lys 114Glu): a variant with complete loss of heparin affinity.
Thrombosis and haemostasis 2002;88(3):436-43.
2002: Trevor P Baglin; Robin W Carrell; Frank Church; Charles T Esmon; James A Huntington
Crystal structures of native and thrombin-complexed heparin cofactor II reveal a multistep allosteric mechanism.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(17):11079-84.
2002: Klara J Belzar; Aiwu Zhou; Robin W Carrell; Peter G W Gettins; James A Huntington
Helix D elongation and allosteric activation of antithrombin.
The Journal of biological chemistry 2002;277(10):8551-8.
2001: Aiwu Zhou; Robin W Carrell; James A Huntington
The serpin inhibitory mechanism is critically dependent on the length of the reactive center loop.
The Journal of biological chemistry 2001;276(29):27541-7.
2001: Robin W Carrell; James A Huntington; Alec Mushunje; Aiwu Zhou
The conformational basis of thrombosis.
Thrombosis and haemostasis 2001;86(1):14-22.
2001: James A Huntington; Penelope E Stein
Structure and properties of ovalbumin.
Journal of chromatography. B, Biomedical sciences and applications 2001;756(1-2):189-98.
2001: James A Huntington; Robin W Carrell
The serpins: nature's molecular mousetraps.
Science progress 2001;84(Pt 2):125-36.
2000: James A Huntington; Randy J Read; Robin W Carrell
Structure of a serpin-protease complex shows inhibition by deformation.
Nature 2000;407(6806):923-6.
2000: James A Huntington; A McCoy; Klara J Belzar; Xue Yuan Pei; Peter G W Gettins; Robin W Carrell
The conformational activation of antithrombin. A 2.85-A structure of a fluorescein derivative reveals an electrostatic link between the hinge and heparin binding regions.
The Journal of biological chemistry 2000;275(20):15377-83.
2000: Klara J Belzar; Timothy R Dafforn; M Petitou; Robin W Carrell; James A Huntington
The effect of a reducing-end extension on pentasaccharide binding by antithrombin.
The Journal of biological chemistry 2000;275(12):8733-41.
1999: Aiwu Zhou; James A Huntington; Robin W Carrell
Formation of the antithrombin heterodimer in vivo and the onset of thrombosis.
Blood 1999;94(10):3388-96.
1999: James A Huntington; Neesh Pannu; Bart Hazes; Randy J Read; David A Lomas; Robin W Carrell
A 2.6 A structure of a serpin polymer and implications for conformational disease.
Journal of molecular biology 1999;293(3):449-55.
1998: Richard Skinner; Wun-Shaing W Chang; L Jin; X Pei; James A Huntington; Jan Pieter Abrahams; Robin W Carrell; David A Lomas
Implications for function and therapy of a 2.9 A structure of binary-complexed antithrombin.
Journal of molecular biology 1998;283(1):9-14.