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DJ Hupe

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Chemicals & Drugs

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Publications

TOP 3
Susan E Hagen; John D Domagala; C Gajda; M Lovdahl; Bradley D Tait; E Wise; T Holler; DJ Hupe; C Nouhan; A Urumov; G Zeikus; E Zeikus; Elizabeth A Lunney; Alexander Pavlovsky; Stephen J Gracheck; J Saunders; S VanderRoest; Joanne Brodfuehrer
4-Hydroxy-5,6-dihydropyrones as inhibitors of HIV protease: the effect of heterocyclic substituents at C-6 on antiviral potency and pharmacokinetic parameters.
LL Johnson; Alexander Pavlovsky; Adam R Johnson; J A Janowicz; Chiu-Fai Man; Daniel F Ortwine; C F Purchase; A D White; DJ Hupe
A rationalization of the acidic pH dependence for stromelysin-1 (Matrix metalloproteinase-3) catalysis and inhibition.
Frederick E Boyer; J V N Vara Prasad; John M Domagala; Edmund L Ellsworth; C Gajda; Susan E Hagen; LJ Markoski; Bradley D Tait; Elizabeth A Lunney; A Palovsky; D Ferguson; N Graham; T Holler; DJ Hupe; C Nouhan; PJ Tummino; A Urumov; E Zeikus; G Zeikus; Stephen J Gracheck; J M Sanders; S VanderRoest; Joanne Brodfuehrer; K Iyer; M Sinz; Sergei V Gulnik
5,6-Dihydropyran-2-ones possessing various sulfonyl functionalities: potent nonpeptidic inhibitors of HIV protease.

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All Publications

2001: Susan E Hagen; John D Domagala; C Gajda; M Lovdahl; Bradley D Tait; E Wise; T Holler; DJ Hupe; C Nouhan; A Urumov; G Zeikus; E Zeikus; Elizabeth A Lunney; Alexander Pavlovsky; Stephen J Gracheck; J Saunders; S VanderRoest; Joanne Brodfuehrer
4-Hydroxy-5,6-dihydropyrones as inhibitors of HIV protease: the effect of heterocyclic substituents at C-6 on antiviral potency and pharmacokinetic parameters.
Journal of medicinal chemistry 2001;44(14):2319-32.
2000: LL Johnson; Alexander Pavlovsky; Adam R Johnson; J A Janowicz; Chiu-Fai Man; Daniel F Ortwine; C F Purchase; A D White; DJ Hupe
A rationalization of the acidic pH dependence for stromelysin-1 (Matrix metalloproteinase-3) catalysis and inhibition.
The Journal of biological chemistry 2000;275(15):11026-33.
2000: Frederick E Boyer; J V N Vara Prasad; John M Domagala; Edmund L Ellsworth; C Gajda; Susan E Hagen; LJ Markoski; Bradley D Tait; Elizabeth A Lunney; A Palovsky; D Ferguson; N Graham; T Holler; DJ Hupe; C Nouhan; PJ Tummino; A Urumov; E Zeikus; G Zeikus; Stephen J Gracheck; J M Sanders; S VanderRoest; Joanne Brodfuehrer; K Iyer; M Sinz; Sergei V Gulnik
5,6-Dihydropyran-2-ones possessing various sulfonyl functionalities: potent nonpeptidic inhibitors of HIV protease.
Journal of medicinal chemistry 2000;43(5):843-58.
1999: J V N Vara Prasad; Frederick E Boyer; John M Domagala; Edmund L Ellsworth; C Gajda; Harriet W Hamilton; Susan E Hagen; LJ Markoski; B A Steinbaugh; Bradley D Tait; Christine Humblet; Elizabeth A Lunney; Alexander Pavlovsky; John R Rubin; D Ferguson; N Graham; T Holler; DJ Hupe; C Nouhan; PJ Tummino; A Urumov; E Zeikus; G Zeikus; Stephen J Gracheck; John W Erickson
Nonpeptidic HIV protease inhibitors possessing excellent antiviral activities and therapeutic indices. PD 178390: a lead HIV protease inhibitor.
Bioorganic & medicinal chemistry 1999;7(12):2775-800.
1999: J V N Vara Prasad; LJ Markoski; Frederick E Boyer; John M Domagala; Edmund L Ellsworth; C Gajda; Susan E Hagen; Bradley D Tait; Elizabeth A Lunney; PJ Tummino; D Ferguson; T Holler; DJ Hupe; C Nouhan; Stephen J Gracheck; S VanderRoest; J Saunders; K Iyer; M Sinz
Nonpeptidic HIV protease inhibitors: 6-alkyl-5,6-dihydropyran-2-ones possessing a novel and achiral 3-(2-t-butyl-5-methyl-4-sulfamate)phenylthio moiety.
Bioorganic & medicinal chemistry letters 1999;9(15):2217-22.
1999: Edmund L Ellsworth; John D Domagala; J V N Vara Prasad; S Hagen; D Ferguson; T Holler; DJ Hupe; N Graham; C Nouhan; PJ Tummino; G Zeikus; Elizabeth A Lunney
4-hydroxy-5,6-dihydro-2H-pyran-2-ones.3. Bicyclic and hetero-aromatic ring systems as 3-position scaffolds to bind to S1' and S2' of the HIV-1 protease enzyme.
Bioorganic & medicinal chemistry letters 1999;9(14):2019-24.
1999: Alexander Pavlovsky; M G Williams; Q Z Ye; Daniel F Ortwine; C F Purchase; A D White; Venugopal Dhanaraj; Bruce D Roth; LL Johnson; DJ Hupe; Christine Humblet; Tom L Blundell
X-ray structure of human stromelysin catalytic domain complexed with nonpeptide inhibitors: implications for inhibitor selectivity.
Protein science : a publication of the Protein Society 1999;8(7):1455-62.
1999: J V N Vara Prasad; Frederick E Boyer; John M Domagala; Edmund L Ellsworth; C Gajda; Susan E Hagen; LJ Markoski; Bradley D Tait; Elizabeth A Lunney; PJ Tummino; D Ferguson; T Holler; DJ Hupe; C Nouhan; Stephen J Gracheck; S VanderRoest; J Saunders; K Iyer; M Sinz; Joanne Brodfuehrer
Nonpeptidic HIV protease inhibitors: 6-alkyl-5,6-dihydropyran-2-ones possessing achiral 3-(4-amino/carboxamide-2-t-butyl,5-methylphenyl thio) moiety: antiviral activities and pharmacokinetic properties.
Bioorganic & medicinal chemistry letters 1999;9(11):1481-6.
1998: KK Zimmerman; Jeffrey D Scholten; C C Huang; Carol A Fierke; DJ Hupe
High-level expression of rat farnesyl:protein transferase in Escherichia coli as a translationally coupled heterodimer.
Protein expression and purification 1998;14(3):395-402.
1998: LL Johnson; R Dyer; DJ Hupe
Matrix metalloproteinases.
Current opinion in chemical biology 1998;2(4):466-71.
1998: Kyunghye Ahn; A M Sisneros; SB Herman; S M Pan; DJ Hupe; C Lee; S Nikam; XM Cheng; AM Doherty; RL Schroeder; Stephen J Haleen; S Kaw; N Emoto; M Yanagisawa
Novel selective quinazoline inhibitors of endothelin converting enzyme-1.
Biochemical and biophysical research communications 1998;243(1):184-90.
1997: Bradley D Tait; S Hagen; John D Domagala; Edmund L Ellsworth; C Gajda; Harriet W Hamilton; J V N Vara Prasad; D Ferguson; N Graham; DJ Hupe; C Nouhan; PJ Tummino; Christine Humblet; Elizabeth A Lunney; Alexander Pavlovsky; J Rubin; Stephen J Gracheck; Eric Baldwin; TN Bhat; John W Erickson; Sergei V Gulnik; B Liu
4-hydroxy-5,6-dihydropyrones. 2. Potent non-peptide inhibitors of HIV protease.
Journal of medicinal chemistry 1997;40(23):3781-92.
1997: Susan E Hagen; J V N Vara Prasad; Frederick E Boyer; John M Domagala; Edmund L Ellsworth; C Gajda; Harriet W Hamilton; LJ Markoski; B A Steinbaugh; Bradley D Tait; Elizabeth A Lunney; PJ Tummino; D Ferguson; DJ Hupe; C Nouhan; Stephen J Gracheck; J M Saunders; S VanderRoest
Synthesis of 5,6-dihydro-4-hydroxy-2-pyrones as HIV-1 protease inhibitors: the profound effect of polarity on antiviral activity.
Journal of medicinal chemistry 1997;40(23):3707-11.
1997: Jeffrey D Scholten; KK Zimmerman; M G Oxender; D Leonard; Judith Leopold; Richard C Gowan; DJ Hupe
Synergy between anions and farnesyldiphosphate competitive inhibitors of farnesyl:protein transferase.
The Journal of biological chemistry 1997;272(29):18077-81.
1997: John M Domagala; RD Gogliotti; Joseph P Sanchez; Michael A Stier; K Musa; Y Song; Joseph A Loo; M Reily; PJ Tummino; P Harvey; DJ Hupe; L Sharmeen; D Mack; JD Scholten; J Saunders; T McQuade
2,2'-Dithiobisbenzamides and 2-benzisothiazolones, two new classes of antiretroviral agents: SAR and mechanistic considerations.
Drug design and discovery 1997;15(1):49-61.
1997: John M Domagala; JP Bader; RD Gogliotti; Joseph P Sanchez; Michael A Stier; Y Song; J V N Vara Prasad; PJ Tummino; JD Scholten; P Harvey; T Holler; Stephen J Gracheck; DJ Hupe; William G Rice; R Schultz
A new class of anti-HIV-1 agents targeted toward the nucleocapsid protein NCp7: the 2,2'-dithiobisbenzamides.
Bioorganic & medicinal chemistry 1997;5(3):569-79.
1997: PJ Tummino; P J Harvey; T McQuade; John D Domagala; RD Gogliotti; J Sanchez; Y Song; DJ Hupe
The human immunodeficiency virus type 1 (HIV-1) nucleocapsid protein zinc ejection activity of disulfide benzamides and benzisothiazolones: correlation with anti-HIV and virucidal activities.
Antimicrobial agents and chemotherapy 1997;41(2):394-400.