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Ted Hupp

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Chemicals & Drugs

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Ted R Hupp; Richard L Hayward; Borek Vojtesek
Strategies for p53 reactivation in human sarcoma.
Terry A Gray; Larry Hayward; Jacqueline Howie; Roman Hrstka; Simon Langdon; Nicola J MacLaine; Magdalena M Maslon; Caroline O Michie; Euan Murray; Rudolf Nenutil; Borivoj Vojtesek; Pavla Bouchalova; Charlie Gourley; Ted R Hupp
Anterior Gradient-3: a novel biomarker for ovarian cancer that mediates cisplatin resistance in xenograft models.
Anne-Sophie Huart; Nicola J MacLaine; Vikram Narayan; Ted R Hupp
Exploiting the MDM2-CK1α protein-protein interface to develop novel biologics that induce UBL-kinase-modification and inhibit cell growth.

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All Publications

2012: Ted R Hupp; Richard L Hayward; Borek Vojtesek
Strategies for p53 reactivation in human sarcoma.
Cancer cell 2012;22(3):283-5.
2012: Terry A Gray; Larry Hayward; Jacqueline Howie; Roman Hrstka; Simon Langdon; Nicola J MacLaine; Magdalena M Maslon; Caroline O Michie; Euan Murray; Rudolf Nenutil; Borivoj Vojtesek; Pavla Bouchalova; Charlie Gourley; Ted R Hupp
Anterior Gradient-3: a novel biomarker for ovarian cancer that mediates cisplatin resistance in xenograft models.
Journal of immunological methods 2012;378(1-2):20-32.
2012: Anne-Sophie Huart; Nicola J MacLaine; Vikram Narayan; Ted R Hupp
Exploiting the MDM2-CK1α protein-protein interface to develop novel biologics that induce UBL-kinase-modification and inhibit cell growth.
PloS one 2012;7(8):e43391.
2011: David J Clarke; Ted R Hupp; C Logan Mackay; Euan Murray; Pat R R Langridge-Smith
Mapping a noncovalent protein-peptide interface by top-down FTICR mass spectrometry using electron capture dissociation.
Journal of the American Society for Mass Spectrometry 2011;22(8):1432-40.
2011: Jenna Scotcher; David J Clarke; Stefan K Weidt; C Logan Mackay; Ted R Hupp; Peter J Sadler; Pat R R Langridge-Smith
Identification of two reactive cysteine residues in the tumor suppressor protein p53 using top-down FTICR mass spectrometry.
Journal of the American Society for Mass Spectrometry 2011;22(5):888-97.
2011: Lisa Y Pang; Mary Scott; Richard L Hayward; Hisham Mohammed; C Bruce A Whitelaw; Graeme C M Smith; Ted R Hupp
p21(WAF1) is component of a positive feedback loop that maintains the p53 transcriptional program.
Cell cycle (Georgetown, Tex.) 2011;10(6):932-50.
2011: Nicola J MacLaine; Ted R Hupp
How phosphorylation controls p53.
Cell cycle (Georgetown, Tex.) 2011;10(6):916-21.
2010: Magdalena M Maslon; Roman Hrstka; Borivoj Vojtesek; Ted R Hupp
A divergent substrate-binding loop within the pro-oncogenic protein anterior gradient-2 forms a docking site for Reptin.
Journal of molecular biology 2010;404(3):418-38.
2010: Jennifer A Fraser; Borivoj Vojtesek; Ted R Hupp
A novel p53 phosphorylation site within the MDM2 ubiquitination signal: I. phosphorylation at SER269 in vivo is linked to inactivation of p53 function.
The Journal of biological chemistry 2010;285(48):37762-72.
2010: Jennifer A Fraser; Arumugam Madhumalar; Elizabeth Blackburn; Janice Bramham; Malcolm D Walkinshaw; Chandra Verma; Ted R Hupp
A novel p53 phosphorylation site within the MDM2 ubiquitination signal: II. a model in which phosphorylation at SER269 induces a mutant conformation to p53.
The Journal of biological chemistry 2010;285(48):37773-86.
2010: Magda M Maslon; Ted R Hupp
Drug discovery and mutant p53.
Trends in cell biology 2010;20(9):542-55.
2010: Roman Hrstka; Rudolf Nenutil; A Fourtouna; M M Maslon; C Naughton; S Langdon; E Murray; A Larionov; K Petrakova; P Muller; M J Dixon; Ted R Hupp; Borivoj Vojtesek
The pro-metastatic protein anterior gradient-2 predicts poor prognosis in tamoxifen-treated breast cancers.
Oncogene 2010;29(34):4838-47.
2010: Erin G Worrall; Liam Worrall; Elizabeth Blackburn; Malcolm D Walkinshaw; Ted R Hupp
The effects of phosphomimetic lid mutation on the thermostability of the N-terminal domain of MDM2.
Journal of molecular biology 2010;398(3):414-28.
2010: David W Meek; Ted R Hupp
The regulation of MDM2 by multisite phosphorylation--opportunities for molecular-based intervention to target tumours?
Seminars in cancer biology 2010;20(1):19-28.
2010: Ashley L Craig; Jitka Holcakova; Lee E Finlan; Marta Nekulova; Roman Hrstka; Nuri Gueven; James DiRenzo; Graeme Smith; Ted R Hupp; Borivoj Vojtesek
DeltaNp63 transcriptionally regulates ATM to control p53 Serine-15 phosphorylation.
Molecular cancer 2010;9():195.
2010: Ted R Hupp
Death-associated protein kinase (DAPK) and signal transduction.
The FEBS journal 2010;277(1):47.
2010: Yao Lin; Ted R Hupp; Craig Stevens
Death-associated protein kinase (DAPK) and signal transduction: additional roles beyond cell death.
The FEBS journal 2010;277(1):48-57.
2009: Anne-Sophie Huart; Nicola J MacLaine; David W Meek; Ted R Hupp
CK1alpha plays a central role in mediating MDM2 control of p53 and E2F-1 protein stability.
The Journal of biological chemistry 2009;284(47):32384-94.
2009: Erin G Worrall; Bartosz Wawrzynow; Liam Worrall; Malcolm Walkinshaw; Kathryn L Ball; Ted R Hupp
Regulation of the E3 ubiquitin ligase activity of MDM2 by an N-terminal pseudo-substrate motif.
Journal of chemical biology 2009;2(3):113-29.
2009: Yao Lin; Craig Stevens; Ben Harrison; Suresh Pathuri; Eliana Amin; Ted R Hupp
The alternative splice variant of DAPK-1, s-DAPK-1, induces proteasome-independent DAPK-1 destabilization.
Molecular and cellular biochemistry 2009;328(1-2):101-7.
2009: Nicola J Maclaine; Ted R Hupp
The regulation of p53 by phosphorylation: a model for how distinct signals integrate into the p53 pathway.
Aging 2009;1(5):490-502.
2009: Bartosz Wawrzynow; Susanne Pettersson; Alicja Zylicz; Janice Bramham; Erin Worrall; Ted R Hupp; Kathryn L Ball
A function for the RING finger domain in the allosteric control of MDM2 conformation and activity.
The Journal of biological chemistry 2009;284(17):11517-30.
2009: Craig Stevens; Yao Lin; Ben Harrison; Lindsay Burch; Rachel A Ridgway; Owen J Sansom; Ted R Hupp
Peptide combinatorial libraries identify TSC2 as a death-associated protein kinase (DAPK) death domain-binding protein and reveal a stimulatory role for DAPK in mTORC1 signaling.
The Journal of biological chemistry 2009;284(1):334-44.
2008: Nicola J MacLaine; Bodil Oster; Bettina Bundgaard; Jennifer A Fraser; Carolyn Buckner; Pedro A Lazo; David W Meek; Per Höllsberg; Ted R Hupp
A central role for CK1 in catalyzing phosphorylation of the p53 transactivation domain at serine 20 after HHV-6B viral infection.
The Journal of biological chemistry 2008;283(42):28563-73.
2008: Maximillian Groome; Jamie Lindsay; Peter E Ross; James P Cotton; Ted R Hupp; John F Dillon
Use of oesophageal stress response proteins as potential biomarkers in the screening for Barrett's oesophagus.
European journal of gastroenterology & hepatology 2008;20(10):961-5.
2008: Craig Stevens; Susanne Pettersson; Bartosz Wawrzynow; Maura Wallace; Kathryn Ball; Alicja Zylicz; Ted R Hupp
ATP stimulates MDM2-mediated inhibition of the DNA-binding function of E2F1.
The FEBS journal 2008;275(19):4875-86.
2008: Lisa Y Pang; Ted R Hupp
Protein kinases coordinately regulate the p53: Delta Np63 alpha axis after DNA damage.
Cell cycle (Georgetown, Tex.) 2008;7(18):2779-80.
2008: Lenny Nelson; Susan Anderson; Alan L Archibald; Susan Rhind; Zen H Lu; Alison Condie; Neal McIntyre; Jill Thompson; Rudolf Nenutil; Borivoj Vojtesek; C Bruce A Whitelaw; Tom J Little; Ted R Hupp
An animal model to evaluate the function and regulation of the adaptively evolving stress protein SEP53 in oesophageal bile damage responses.
Cell stress & chaperones 2008;13(3):375-85.
2008: C Logan Mackay; Bernard Ramsahoye; Karl Burgess; Ken Cook; Stefan Weidt; James Creanor; David Harrison; Pat Langridge-Smith; Ted R Hupp; Larry Hayward
Sensitive, specific, and quantitative FTICR mass spectrometry of combinatorial post-translational modifications in intact histone H4.
Analytical chemistry 2008;80(11):4147-53.
2008: Yao Lin; Craig Stevens; Roman Hrstka; Ben Harrison; Argyro Fourtouna; Suresh Pathuri; Borivoj Vojtesek; Ted R Hupp
An alternative transcript from the death-associated protein kinase 1 locus encoding a small protein selectively mediates membrane blebbing.
The FEBS journal 2008;275(10):2574-84.
2008: Craig Stevens; Ted R Hupp
Novel insights into DAPK autophagic signalling using peptide aptamer combinatorial protein-interaction screens.
Autophagy 2008;4(4):531-3.
2008: Ben Harrison; Michaela Kraus; Lindsay Burch; Craig Stevens; Ashley Craig; Phillip Gordon-Weeks; Ted R Hupp
DAPK-1 binding to a linear peptide motif in MAP1B stimulates autophagy and membrane blebbing.
The Journal of biological chemistry 2008;283(15):9999-10014.
2007: Euan Murray; Ekaterina O McKenna; Lindsay R Burch; John Dillon; Pat Langridge-Smith; Walter Kolch; Andrew Pitt; Ted R Hupp
Microarray-formatted clinical biomarker assay development using peptide aptamers to anterior gradient-2.
Biochemistry 2007;46(48):13742-51.
2007: Yao Lin; Craig Stevens; Ted R Hupp
Identification of a dominant negative functional domain on DAPK-1 that degrades DAPK-1 protein and stimulates TNFR-1-mediated apoptosis.
The Journal of biological chemistry 2007;282(23):16792-802.
2007: Craig Stevens; Yao Lin; Maria Sanchez; Eliana Amin; Ellen Copson; Helen White; Vicky Durston; Diana M Eccles; Ted R Hupp
A germ line mutation in the death domain of DAPK-1 inactivates ERK-induced apoptosis.
The Journal of biological chemistry 2007;282(18):13791-803.
2007: Lee E Finlan; Ted R Hupp
p63: the phantom of the tumor suppressor.
Cell cycle (Georgetown, Tex.) 2007;6(9):1062-71.
2007: Ashley L Craig; Jennifer A Chrystal; Jennifer A Fraser; Nathalie Sphyris; Yao Lin; Ben J Harrison; Mary T Scott; Irena Dornreiter; Ted R Hupp
The MDM2 ubiquitination signal in the DNA-binding domain of p53 forms a docking site for calcium calmodulin kinase superfamily members.
Molecular and cellular biology 2007;27(9):3542-55.
2007: Jennifer A Fraser; Ted R Hupp
Chemical genetics approach to identify peptide ligands that selectively stimulate DAPK-1 kinase activity.
Biochemistry 2007;46(10):2655-73.
2007: M Achison; M T Boylan; Ted R Hupp; Barbara A Spruce
HIF-1alpha contributes to tumour-selective killing by the sigma receptor antagonist rimcazole.
Oncogene 2007;26(8):1137-46.
2007: Tom J Little; Lenny Nelson; Ted R Hupp
Adaptive evolution of a stress response protein.
PloS one 2007;2(10):e1003.
2006: Lee E Finlan; Rudolf Nenutil; Sally H Ibbotson; Borivoj Vojtesek; Ted R Hupp
CK2-site phosphorylation of p53 is induced in DeltaNp63 expressing basal stem cells in UVB irradiated human skin.
Cell cycle (Georgetown, Tex.) 2006;5(21):2489-94.
2006: Maura Wallace; Erin Worrall; Susanne Pettersson; Ted R Hupp; Kathryn L Ball
Dual-site regulation of MDM2 E3-ubiquitin ligase activity.
Molecular cell 2006;23(2):251-63.
2006: Harumi Shimizu; David Saliba; Maura Wallace; Lee E Finlan; Patrick R R Langridge-Smith; Ted R Hupp
Destabilizing missense mutations in the tumour suppressor protein p53 enhance its ubiquitination in vitro and in vivo.
The Biochemical journal 2006;397(2):355-67.
2006: Joanne Darragh; Mairi Hunter; Elizabeth Pohler; Lenny Nelson; John F Dillon; Rudolf Nenutil; Borivoj Vojtesek; Peter E Ross; Neil M Kernohan; Ted R Hupp
The calcium-binding domain of the stress protein SEP53 is required for survival in response to deoxycholic acid-mediated injury.
The FEBS journal 2006;273(9):1930-47.
2006: Pavla Ceskova; Havovi Chichger; Maura Wallace; Borivoj Vojtesek; Ted R Hupp
On the mechanism of sequence-specific DNA-dependent acetylation of p53: the acetylation motif is exposed upon DNA binding.
Journal of molecular biology 2006;357(2):442-56.
2005: Lee E Finlan; Neil M Kernohan; George Thomson; Paula E Beattie; Ted R Hupp; Sally H Ibbotson
Differential effects of 5-aminolaevulinic acid photodynamic therapy and psoralen + ultraviolet A therapy on p53 phosphorylation in normal human skin in vivo.
The British journal of dermatology 2005;153(5):1001-10.
2005: Paula E Beattie; Lee E Finlan; Neil M Kernohan; George Thomson; Ted R Hupp; Sally H Ibbotson
The effect of ultraviolet (UV) A1, UVB and solar-simulated radiation on p53 activation and p21.
The British journal of dermatology 2005;152(5):1001-8.
2004: Lee E Finlan; Ted R Hupp
The N-terminal interferon-binding domain (IBiD) homology domain of p300 binds to peptides with homology to the p53 transactivation domain.
The Journal of biological chemistry 2004;279(47):49395-405.
2004: Ashley L Craig; Ted R Hupp
The regulation of CHK2 in human cancer.
Oncogene 2004;23(52):8411-8.
2004: David Dornan; Mirjam Eckert; Maura Wallace; Harumi Shimizu; Eleanor Ramsay; Ted R Hupp; Kathryn L Ball
Interferon regulatory factor 1 binding to p300 stimulates DNA-dependent acetylation of p53.
Molecular and cellular biology 2004;24(22):10083-98.
2004: Elizabeth Pohler; Ashley L Craig; James Cotton; Laura Lawrie; John F Dillon; Pete Ross; Neil M Kernohan; Ted R Hupp
The Barrett's antigen anterior gradient-2 silences the p53 transcriptional response to DNA damage.
Molecular & cellular proteomics : MCP 2004;3(6):534-47.
2004: Sárka Pospísilová; Václav Brázda; Katerina Kucharíková; M Gloria Luciani; Ted R Hupp; Petr Skládal; Emil Palecek; Borivoj Vojtesek
Activation of the DNA-binding ability of latent p53 protein by protein kinase C is abolished by protein kinase CK2.
The Biochemical journal 2004;378(Pt 3):939-47.
2004: Lindsay Burch; Harumi Shimizu; Amanda Smith; Winston Patterson; Ted R Hupp
Expansion of protein interaction maps by phage peptide display using MDM2 as a prototypical conformationally flexible target protein.
Journal of molecular biology 2004;337(1):129-45.
2004: Lindsay Burch; Mary Scott; Elizabeth Pohler; David W Meek; Ted R Hupp
Phage-peptide display identifies the interferon-responsive, death-activated protein kinase family as a novel modifier of MDM2 and p21WAF1.
Journal of molecular biology 2004;337(1):115-28.
2004: Michelle Ferguson; M Gloria Luciani; Lee E Finlan; Elaine M Rankin; Sally H Ibbotson; Alan Fersht; Ted R Hupp
The development of a CDK2-docking site peptide that inhibits p53 and sensitizes cells to death.
Cell cycle (Georgetown, Tex.) 2004;3(1):80-9.
2003: David Dornan; Harumi Shimizu; Lindsay Burch; Amanda J Smith; Ted R Hupp
The proline repeat domain of p53 binds directly to the transcriptional coactivator p300 and allosterically controls DNA-dependent acetylation of p53.
Molecular and cellular biology 2003;23(23):8846-61.
2003: Ashley Craig; Mary Scott; Lindsay Burch; Graeme Smith; Kathryn Ball; Ted R Hupp
Allosteric effects mediate CHK2 phosphorylation of the p53 transactivation domain.
EMBO reports 2003;4(8):787-92.
2003: Harumi Shimizu; Ted R Hupp
Intrasteric regulation of MDM2.
Trends in biochemical sciences 2003;28(7):346-9.
2003: Marcus Achison; Ted R Hupp
Hypoxia attenuates the p53 response to cellular damage.
Oncogene 2003;22(22):3431-40.
2003: A A Liem; M V C L Appleyard; M A O'Neill; Ted R Hupp; Mark Chamberlain; Alastair Thompson
Doxorubicin and vinorelbine act independently via p53 expression and p38 activation respectively in breast cancer cell lines.
British journal of cancer 2003;88(8):1281-4.
2003: David P Lane; Ted R Hupp
Drug discovery and p53.
Drug discovery today 2003;8(8):347-55.
2003: David Dornan; Harumi Shimizu; Neil D Perkins; Ted R Hupp
DNA-dependent acetylation of p53 by the transcription coactivator p300.
The Journal of biological chemistry 2003;278(15):13431-41.
2003: Ashley L Craig; Susan E Bray; Lee E Finlan; Neil M Kernohan; Ted R Hupp
Signaling to p53: the use of phospho-specific antibodies to probe for in vivo kinase activation.
Methods in molecular biology (Clifton, N.J.) 2003;234():171-202.
2002: Harumi Shimizu; Lindsay Burch; Amanda J Smith; David Dornan; Maura Wallace; Kathryn L Ball; Ted R Hupp
The conformationally flexible S9-S10 linker region in the core domain of p53 contains a novel MDM2 binding site whose mutation increases ubiquitination of p53 in vivo.
The Journal of biological chemistry 2002;277(32):28446-58.
2001: G Nicoll; DN Crichton; HE McDowell; Neil M Kernohan; Ted R Hupp; Alastair Thompson
Expression of the Hypermethylated in Cancer gene (HIC-1) is associated with good outcome in human breast cancer.
British journal of cancer 2001;85(12):1878-82.
2001: HM Ball; Ted R Hupp; Dorin Ziyaie; C A Purdie; Neil M Kernohan; Alastair Thompson
Differential p53 protein expression in breast cancer fine needle aspirates: the potential for in vivo monitoring.
British journal of cancer 2001;85(8):1102-5.
2001: A Yagui-Beltran; Ashley L Craig; L Lawrie; D Thompson; Sarka Pospisilova; D Johnston; Neil M Kernohan; D Hopwood; John F Dillon; Ted R Hupp
The human oesophageal squamous epithelium exhibits a novel type of heat shock protein response.
European journal of biochemistry / FEBS 2001;268(20):5343-55.
2001: JP Blaydes; M Gloria Luciani; Sarka Pospisilova; HM Ball; Borivoj Vojtesek; Ted R Hupp
Stoichiometric phosphorylation of human p53 at Ser315 stimulates p53-dependent transcription.
The Journal of biological chemistry 2001;276(7):4699-708.
2001: David Dornan; Ted R Hupp
Inhibition of p53-dependent transcription by BOX-I phospho-peptide mimetics that bind to p300.
EMBO reports 2001;2(2):139-44.
2000: Ted R Hupp; David P Lane; Kathryn L Ball
Strategies for manipulating the p53 pathway in the treatment of human cancer.
The Biochemical journal 2000;352 Pt 1():1-17.
2000: Dorin Ziyaie; Ted R Hupp; Alastair Thompson
P53 and breast cancer.
Breast (Edinburgh, Scotland) 2000;9(5):239-46.
2000: JP Blaydes; Ashley L Craig; Maura Wallace; HM Ball; Nicola J Traynor; Neil K Gibbs; Ted R Hupp
Synergistic activation of p53-dependent transcription by two cooperating damage recognition pathways.
Oncogene 2000;19(34):3829-39.
2000: M Gloria Luciani; James Hutchins; D Zheleva; Ted R Hupp
The C-terminal regulatory domain of p53 contains a functional docking site for cyclin A.
Journal of molecular biology 2000;300(3):503-18.
2000: Lindsay Burch; CA Midgley; RA Currie; David P Lane; Ted R Hupp
Mdm2 binding to a conformationally sensitive domain on p53 can be modulated by RNA.
FEBS letters 2000;472(1):93-8.
2000: K Webley; Jane A Bond; Christopher John Jones; JP Blaydes; A Craig; Ted R Hupp; David Wynford-Thomas
Posttranslational modifications of p53 in replicative senescence overlapping but distinct from those induced by DNA damage.
Molecular and cellular biology 2000;20(8):2803-8.
2000: Ted R Hupp
Development of physiological models to study stress protein responses.
Methods in molecular biology (Clifton, N.J.) 2000;99():465-83.
2000: JP Blaydes; Borivoj Vojtesek; G B Bloomberg; Ted R Hupp
The development and use of phospho-specific antibodies to study protein phosphorylation.
Methods in molecular biology (Clifton, N.J.) 2000;99():177-89.
1999: P A Cohen; Ted R Hupp; David P Lane; D A Daniels
Biochemical characterization of different conformational states of the Sf9 cell-purified p53His175 mutant protein.
FEBS letters 1999;463(1-2):179-84.
1999: Ashley L Craig; JP Blaydes; Lindsay Burch; A M Thompson; Ted R Hupp
Dephosphorylation of p53 at Ser20 after cellular exposure to low levels of non-ionizing radiation.
Oncogene 1999;18(46):6305-12.
1999: Ashley L Craig; Lindsay Burch; Borivoj Vojtesek; J Mikutowska; A Thompson; Ted R Hupp
Novel phosphorylation sites of human tumour suppressor protein p53 at Ser20 and Thr18 that disrupt the binding of mdm2 (mouse double minute 2) protein are modified in human cancers.
The Biochemical journal 1999;342 ( Pt 1)():133-41.
1999: Jane A Bond; K Webley; Fiona S Wyllie; Christopher John Jones; A Craig; Ted R Hupp; David Wynford-Thomas
p53-Dependent growth arrest and altered p53-immunoreactivity following metabolic labelling with 32P ortho-phosphate in human fibroblasts.
Oncogene 1999;18(25):3788-92.
1999: JP Blaydes; A Sparks; Ted R Hupp
Activation of p53 protein function in response to cellular irradiation.
Methods in molecular biology (Clifton, N.J.) 1999;113():591-8.
1999: DE MacCallum; Ted R Hupp
Induction of p53 protein as a marker for ionizing radiation exposure in vivo.
Methods in molecular biology (Clifton, N.J.) 1999;113():583-9.
1998: JP Blaydes; Ted R Hupp
DNA damage triggers DRB-resistant phosphorylation of human p53 at the CK2 site.
Oncogene 1998;17(8):1045-52.
1997: Emil Palecek; D Vlk; V Stanková; Václav Brázda; Borivoj Vojtesek; Ted R Hupp; A Schaper; Thomas M Jovin
Tumor suppressor protein p53 binds preferentially to supercoiled DNA.
Oncogene 1997;15(18):2201-9.
1997: D Hopwood; S Moitra; Borivoj Vojtesek; D A Johnston; John F Dillon; Ted R Hupp
Biochemical analysis of the stress protein response in human oesophageal epithelium.
Gut 1997;41(2):156-63.
1996: DE MacCallum; Ted R Hupp; CA Midgley; D Stuart; S J Campbell; A Harper; F S Walsh; E G Wright; A Balmain; David P Lane; Peter A Hall
The p53 response to ionising radiation in adult and developing murine tissues.
Oncogene 1996;13(12):2575-87.
1996: S Hansen; CA Midgley; David P Lane; BC Freeman; Richard I Morimoto; Ted R Hupp
Modification of two distinct COOH-terminal domains is required for murine p53 activation by bacterial Hsp70.
The Journal of biological chemistry 1996;271(48):30922-8.
1996: David P Lane; C W Stephen; CA Midgley; Alison Sparks; Ted R Hupp; D A Daniels; R Greaves; A Reid; Borivoj Vojtesek; S M Picksley
Epitope analysis of the murine p53 tumour suppressor protein.
Oncogene 1996;12(11):2461-6.
1996: N M Kernohan; Ted R Hupp; David P Lane
Modification of an N-terminal regulatory domain of T antigen restores p53-T antigen complex formation in the absence of an essential metal ion cofactor.
The Journal of biological chemistry 1996;271(9):4954-60.
1996: S Hansen; Ted R Hupp; David P Lane
Allosteric regulation of the thermostability and DNA binding activity of human p53 by specific interacting proteins. CRC Cell Transformation Group.
The Journal of biological chemistry 1996;271(7):3917-24.
1995: Ted R Hupp; Alison Sparks; David P Lane
Small peptides activate the latent sequence-specific DNA binding function of p53.
Cell 1995;83(2):237-45.
1995: Ted R Hupp; David P Lane
Two distinct signaling pathways activate the latent DNA binding function of p53 in a casein kinase II-independent manner.
The Journal of biological chemistry 1995;270(30):18165-74.
1995: Lynne Cox; Ted R Hupp; CA Midgley; David P Lane
A direct effect of activated human p53 on nuclear DNA replication.
The EMBO journal 1995;14(9):2099-105.
1995: David P Lane; CA Midgley; Ted R Hupp; X Lu; Borivoj Vojtesek; S M Picksley
On the regulation of the p53 tumour suppressor, and its role in the cellular response to DNA damage.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1995;347(1319):83-7.
1994: David P Lane; X Lu; Ted R Hupp; Peter A Hall
The role of the p53 protein in the apoptotic response.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1994;345(1313):277-80.
1994: Ted R Hupp; David P Lane
Regulation of the cryptic sequence-specific DNA-binding function of p53 by protein kinases.
Cold Spring Harbor symposia on quantitative biology 1994;59():195-206.
1993: Ted R Hupp; David W Meek; CA Midgley; David P Lane
Activation of the cryptic DNA binding function of mutant forms of p53.
Nucleic acids research 1993;21(14):3167-74.
1993: David P Lane; CA Midgley; Ted R Hupp
Tumour suppressor genes and molecular chaperones.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1993;339(1289):369-72; discussion 372-3.
1992: Ted R Hupp; David W Meek; CA Midgley; David P Lane
Regulation of the specific DNA binding function of p53.
Cell 1992;71(5):875-86.