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Man-Wook Hur

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Min-Kyeong Kim; Dong-In Koh; So-Yoon Park; Chae-Ok Yun; Bu-Nam Jeon; Kyung-Sup Kim; Man-Wook Hur
Regulation of the cyclin-dependent kinase inhibitor 1A gene (CDKN1A) by the repressor BOZF1 through inhibition of p53 acetylation and transcription factor Sp1 binding.
Curt Balch; Brett Ballard; Man-Wook Hur; Alan Hyslop; Christina Melki; Kaleb Naegeli; Seungyoon Nam; Elizabeth Reilly; Kenneth P Nephew
A unique histone deacetylase inhibitor alters microRNA expression and signal transduction in chemoresistant ovarian cancer cells.
Bu-Nam Jeon; Min-Kyeong Kim; Min-Young Kim; Yeon-Sook Kim; Dong-In Koh; Philip Dong-Hyun Paik; Jae-Hyeon Yoon; Won-Il Choi; Benjamin Hur; Man-Wook Hur
Kr-pok increases FASN expression by modulating the DNA binding of SREBP-1c and Sp1 at the proximal promoter.

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All Publications

2013: Min-Kyeong Kim; Dong-In Koh; So-Yoon Park; Chae-Ok Yun; Bu-Nam Jeon; Kyung-Sup Kim; Man-Wook Hur
Regulation of the cyclin-dependent kinase inhibitor 1A gene (CDKN1A) by the repressor BOZF1 through inhibition of p53 acetylation and transcription factor Sp1 binding.
The Journal of biological chemistry 2013;288(10):7053-64.
2012: Curt Balch; Brett Ballard; Man-Wook Hur; Alan Hyslop; Christina Melki; Kaleb Naegeli; Seungyoon Nam; Elizabeth Reilly; Kenneth P Nephew
A unique histone deacetylase inhibitor alters microRNA expression and signal transduction in chemoresistant ovarian cancer cells.
Cancer biology & therapy 2012;13(8):681-93.
2012: Bu-Nam Jeon; Min-Kyeong Kim; Min-Young Kim; Yeon-Sook Kim; Dong-In Koh; Philip Dong-Hyun Paik; Jae-Hyeon Yoon; Won-Il Choi; Benjamin Hur; Man-Wook Hur
Kr-pok increases FASN expression by modulating the DNA binding of SREBP-1c and Sp1 at the proximal promoter.
Journal of lipid research 2012;53(4):755-66.
2012: Bu-Nam Jeon; Kyung-Sup Kim; Minjung Kim; Min-Kyeong Kim; Dong-In Koh; Kyung-Ryul Lee; Kenneth P Nephew; Juyong Yoon; Chae-Ok Yun; Kang-Yell Choi; Won-Il Choi; Sung-Yi Hong; Man-Wook Hur
KR-POK interacts with p53 and represses its ability to activate transcription of p21WAF1/CDKN1A.
Cancer research 2012;72(5):1137-48.
2012: Jung-Sun Lee; Seong Kyung Lee; Won-Il Choi; Man-Wook Hur; Young-Guen Kwon; Chae-Ok Yun
A novel sLRP6E1E2 inhibits canonical Wnt signaling, epithelial-to-mesenchymal transition, and induces mitochondria-dependent apoptosis in lung cancer.
PloS one 2012;7(5):e36520.
2010: Pil-Geum Jang; Cherl Namkoong; Gil Myoung Kang; Man-Wook Hur; Seung-Whan Kim; Geun Hyang Kim; Yeoungsup Kang; Min-Jae Jeon; Eun Hee Kim; Myung-Shik Lee; Michael Karin; Ja-Hyun Baik; Joong-Yeol Park; Ki-Up Lee; Young-Bum Kim; Min-Seon Kim
NF-kappaB activation in hypothalamic pro-opiomelanocortin neurons is essential in illness- and leptin-induced anorexia.
The Journal of biological chemistry 2010;285(13):9706-15.
2009: Dong-In Koh; Won-Il Choi; Bu-Nam Jeon; Choong-Eun Lee; Chae-Ok Yun; Man-Wook Hur
A novel POK family transcription factor, ZBTB5, represses transcription of p21CIP1 gene.
The Journal of biological chemistry 2009;284(30):19856-66.
2009: Bu-Nam Jeon; Won-Il Choi; Mi-Young Yu; A-Rum Yoon; Myung-Hwa Kim; Chae-Ok Yun; Man-Wook Hur
ZBTB2, a novel master regulator of the p53 pathway.
The Journal of biological chemistry 2009;284(27):17935-46.
2009: Won-Il Choi; Bu-Nam Jeon; Chae-Ok Yun; Pyung-Hwan Kim; Sung-Eun Kim; Kang-Yell Choi; Se Hoon Kim; Man-Wook Hur
Proto-oncogene FBI-1 represses transcription of p21CIP1 by inhibition of transcription activation by p53 and Sp1.
The Journal of biological chemistry 2009;284(19):12633-44.
2009: Won-Il Choi; Youngsoo Kim; Yuri Kim; Mi-young Yu; Jungeun Park; Choong-Eun Lee; Bu-Nam Jeon; Dong-In Koh; Man-Wook Hur
Eukaryotic translation initiator protein 1A isoform, CCS-3, enhances the transcriptional repression of p21CIP1 by proto-oncogene FBI-1 (Pokemon/ZBTB7A).
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2009;23(4-6):359-70.
2008: Bu-Nam Jeon; Jung-Yoon Yoo; Won-Il Choi; Choong-Eun Lee; Ho-Geun Yoon; Man-Wook Hur
Proto-oncogene FBI-1 (Pokemon/ZBTB7A) represses transcription of the tumor suppressor Rb gene via binding competition with Sp1 and recruitment of co-repressors.
The Journal of biological chemistry 2008;283(48):33199-210.
2008: Won-Il Choi; Bu-Nam Jeon; Hyejin Park; Jung-Yoon Yoo; Yeon-Sook Kim; Dong-In Koh; Myung-Hwa Kim; Yu-Ri Kim; Choong-Eun Lee; Kyung-Sup Kim; Timothy F Osborne; Man-Wook Hur
Proto-oncogene FBI-1 (Pokemon) and SREBP-1 synergistically activate transcription of fatty-acid synthase gene (FASN).
The Journal of biological chemistry 2008;283(43):29341-54.
2007: Beom Soo Shin; Jin Hyuk Seo; Man-Wook Hur; Min-Nyung Lee; Sun Dong Yoo
Pharmacokinetics of GST-TatdMt, a recombinant fusion protein possessing potent anti-obesity activity, in mice.
Archives of pharmacal research 2007;30(9):1162-7.
2007: Beom Soo Shin; Chul Hwan Kim; Min-Nyung Lee; Man-Wook Hur; Kang Choon Lee; Yu Seok Youn; Sun Dong Yoo
Pharmacokinetics of 125I-GST-TatdMt, a recombinant fusion protein possessing potent anti-obesity activity, after intravenous, nasal, oral, and subcutaneous administration.
Regulatory peptides 2007;140(1-2):74-80.
2007: Myung-Hwa Kim; Hee-Eun Roh; Min-Nyung Lee; Man-Wook Hur
New fast BiFC plasmid assay system for in vivo protein-protein interactions.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2007;20(6):703-14.
2007: Hee-Eun Roh; Min-Nyung Lee; Bu-Nam Jeon; Won-Il Choi; Yoo-Jin Kim; Mi-Young Yu; Man-Wook Hur
Regulation of pokemon 1 activity by sumoylation.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2007;20(1-4):167-80.
2006: Seung-Soon Im; Sool-Ki Kwon; Seung-Youn Kang; Tae-Hyun Kim; Ha-Il Kim; Man-Wook Hur; Kyung-Sup Kim; Yong-Ho Ahn
Regulation of GLUT4 gene expression by SREBP-1c in adipocytes.
The Biochemical journal 2006;399(1):131-9.
2005: Dong-Kee Lee; Jae-Eun Kang; Hye-Jin Park; Myung-Hwa Kim; Tae-Hee Yim; Jung-Min Kim; Min-Kyu Heo; Kyu-Yeun Kim; Ho Jeong Kwon; Man-Wook Hur
FBI-1 enhances transcription of the nuclear factor-kappaB (NF-kappaB)-responsive E-selectin gene by nuclear localization of the p65 subunit of NF-kappaB.
The Journal of biological chemistry 2005;280(30):27783-91.
2005: Jung-Ahn Lee; Dong-Chul Suh; Jae-Eun Kang; Myung-Hwa Kim; Hyejin Park; Min-Nyung Lee; Jung-Min Kim; Bu-Nam Jeon; Hee-Eun Roh; Mi-Young Yu; Kang-Yell Choi; Kyu Yeun Kim; Man-Wook Hur
Transcriptional activity of Sp1 is regulated by molecular interactions between the zinc finger DNA binding domain and the inhibitory domain with corepressors, and this interaction is modulated by MEK.
The Journal of biological chemistry 2005;280(30):28061-71.
2005: Beom Soo Shin; Chul Hwan Kim; Yoon Sik Jun; Eun Hye Park; Man-Wook Hur; Kang Choon Lee; Yu Seok Yoon; Min-Nyung Lee; Sun Dong Yoo
Dose-linear pharmacokinetics, tissue distribution, and excretion of a recombinant fusion protein 125I-GST-TatdMt possessing potent anti-obesity activity.
Regulatory peptides 2005;129(1-3):25-30.
2005: Yeon-Soo Kim; Jung-Min Kim; Deug-Lim Jung; Jae-Eun Kang; Sukyung Lee; Jin Soo Kim; Wongi Seol; Hyun-Chul Shin; Heung Sun Kwon; Carine Van Lint; Nouria Hernandez; Man-Wook Hur
Artificial zinc finger fusions targeting Sp1-binding sites and the trans-activator-responsive element potently repress transcription and replication of HIV-1.
The Journal of biological chemistry 2005;280(22):21545-52.
2005: Jae-Eun Kang; Myung-Hwa Kim; Jeong-Ahn Lee; Hyejin Park; Lee Min-Nyung; Chung-Koon Auh; Man-Wook Hur
Histone deacetylase-1 represses transcription by interacting with zinc-fingers and interfering with the DNA binding activity of Sp1.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2005;16(1-3):23-30.
2004: Yong-Hyun Shin; Jung-Jae Shim; Man-Wook Hur; Chang-Joong Kang; Jiyoung Kim
Involvement of two NF-kappaB binding sites in PMA-induced expression of the human leukotactin-1/CCL15 gene in U937 monocytoid cells.
Molecules and cells 2004;17(2):316-21.
2002: Dongchul Suh; Yu-Kyoung Oh; Byungchan Ahn; Man-Wook Hur; Hye-Ja Kim; Mi-Hyoung Lee; Hyo-Soon Joo; Chung- Kyoon Auh
Comparative binding of antitumor drugs to DNA containing the telomere repeat sequence.
Experimental & molecular medicine 2002;34(5):326-31.
2002: Dongchul Suh; Yu-Kyoung Oh; Man-Wook Hur; Byungchan Ahn; Jonathan B Chaires
Daunomycin binding to deoxypolynucleotides with alternating sequences: complete thermodynamic profiles of heterogeneous binding sites.
Nucleosides, nucleotides & nucleic acids 2002;21(10):637-49.
2002: Dong-Kee Lee; Dongchul Suh; Howard J Edenberg; Man-Wook Hur
POZ domain transcription factor, FBI-1, represses transcription of ADH5/FDH by interacting with the zinc finger and interfering with DNA binding activity of Sp1.
The Journal of biological chemistry 2002;277(30):26761-8.
2002: Myoung H Kim; Jae S Shin; Sungdo Park; Man-Wook Hur; Mi-Ok Lee; Hyoungwoo Park; Chul-Sang Lee
Retinoic acid response element in HOXA-7 regulatory region affects the rate, not the formation of anterior boundary expression.
The International journal of developmental biology 2002;46(3):325-8.
2002: Jiyun Yoo; Moon-Jin Jeong; Byoung-Mog Kwon; Man-Wook Hur; Young-Mee Park; Mi Young Han
Activation of dynamin I gene expression by Sp1 and Sp3 is required for neuronal differentiation of N1E-115 cells.
The Journal of biological chemistry 2002;277(14):11904-9.
2002: Man-Wook Hur; Jeffrey D Laney; Sang-Hack Jeon; Janann Ali; Mark D Biggin
Zeste maintains repression of Ubx transgenes: support for a new model of Polycomb repression.
Development (Cambridge, England) 2002;129(6):1339-43.
2001: Heung Sun Kwon; Dong-Kee Lee; Jae-Jung Lee; Howard J Edenberg; Yong-Ho Ahn; Man-Wook Hur
Posttranscriptional regulation of human ADH5/FDH and Myf6 gene expression by upstream AUG codons.
Archives of biochemistry and biophysics 2001;386(2):163-71.
2000: W J Lee; Sun-Hong Kim; YONG-SIK KIM; S J Han; K S Park; J H Ryu; Man-Wook Hur; Kang-Yell Choi
Inhibition of mitogen-activated protein kinase by a Drosophila dual-specific phosphatase.
The Biochemical journal 2000;349 Pt 3():821-8.
2000: Ji-Young Cha; Hyungsoo Kim; Kyung-Sup Kim; Man-Wook Hur; Y Ahn
Identification of transacting factors responsible for the tissue-specific expression of human glucose transporter type 2 isoform gene. Cooperative role of hepatocyte nuclear factors 1alpha and 3beta.
The Journal of biological chemistry 2000;275(24):18358-65.
1999: Heung Sun Kwon; M S Kim; Howard J Edenberg; Man-Wook Hur
Sp3 and Sp4 can repress transcription by competing with Sp1 for the core cis-elements on the human ADH5/FDH minimal promoter.
The Journal of biological chemistry 1999;274(1):20-8.
1997: Howard J Edenberg; C J Brown; Man-Wook Hur; S Kotagiri; Min Li; L Zhang; X Zhi
Regulation of the seven human alcohol dehydrogenase genes.
Advances in experimental medicine and biology 1997;414():339-45.
1995: Man-Wook Hur; Howard J Edenberg
Cell-specific function of cis-acting elements in the regulation of human alcohol dehydrogenase 5 gene expression and effect of the 5'-nontranslated region.
The Journal of biological chemistry 1995;270(15):9002-9.
1995: Howard J Edenberg; W H Ho; Man-Wook Hur
Promoters of the mammalian class III alcohol dehydrogenase genes.
Advances in experimental medicine and biology 1995;372():295-300.
1992: Man-Wook Hur; Howard J Edenberg
Cloning and characterization of the ADH5 gene encoding human alcohol dehydrogenase 5, formaldehyde dehydrogenase.
Gene 1992;121(2):305-11.
1992: Man-Wook Hur; W H Ho; C J Brown; D Goldman; Howard J Edenberg
Molecular cloning of mouse alcohol dehydrogenase-B2 cDNA: nucleotide sequences of the class III ADH genes evolve slowly even for silent substitutions.
DNA sequence : the journal of DNA sequencing and mapping 1992;3(3):167-75.
1991: Howard J Edenberg; C J Brown; Lucinda G Carr; W H Ho; Man-Wook Hur
Alcohol dehydrogenase gene expression and cloning of the mouse chi-like ADH.
Advances in experimental medicine and biology 1991;284():253-62.