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Arlene Hurley

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HIV-1

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Florian Klein; Zane Kraft; Clara Lehmann; Yan Liu; Lynn Morris; Hugo Mouquet; Gerd Fätkenheuer; Ten Feizi; Christian Gaebler; Arlene Hurley; John Pietzsch; Pascal Poignard; D Noah Sather; Johannes F Scheid; Michael S Seaman; Leonidas Stamatatos; Bruce D Walker; Michel C Nussenzweig
Broad neutralization by a combination of antibodies recognizing the CD4 binding site and a new conformational epitope on the HIV-1 envelope protein.
Johannes F Scheid; Michael S Seaman; Beatrix Ueberheide; Klara Velinzon; Bruce D Walker; Thiago Y K Oliveira; Florencia Pereyra; John Pietzsch; Pascal Poignard; Alexander Abadir; Pamela J Bjorkman; Farid Boulad; Dennis R Burton; Brian T Chait; Ron Diskin; David Fenyo; David D Ho; Arlene Hurley; Florian Klein; Hugo Mouquet; Sunnie Myung; Michel C Nussenzweig
Sequence and structural convergence of broad and potent HIV antibodies that mimic CD4 binding.
Sandhya Vasan; Arlene Hurley; Sarah J Schlesinger; Drew Hannaman; David F Gardiner; Daniel P Dugin; Mar Boente-Carrera; Roselle Vittorino; Marina Caskey; Johanne Andersen; Yaoxing Huang; Josephine H Cox; Tony Tarragona-Fiol; Dilbinder K Gill; Hannah Cheeseman; Lorna Clark; Len Dally; Carol Smith; Claudia Schmidt; Harriet H Park; Jakub T Kopycinski; Jill Gilmour; Patricia Fast; Robert Bernard; David D Ho
In vivo electroporation enhances the immunogenicity of an HIV-1 DNA vaccine candidate in healthy volunteers.

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All Publications

2012: Florian Klein; Zane Kraft; Clara Lehmann; Yan Liu; Lynn Morris; Hugo Mouquet; Gerd Fätkenheuer; Ten Feizi; Christian Gaebler; Arlene Hurley; John Pietzsch; Pascal Poignard; D Noah Sather; Johannes F Scheid; Michael S Seaman; Leonidas Stamatatos; Bruce D Walker; Michel C Nussenzweig
Broad neutralization by a combination of antibodies recognizing the CD4 binding site and a new conformational epitope on the HIV-1 envelope protein.
The Journal of experimental medicine 2012;209(8):1469-79.
2011: Johannes F Scheid; Michael S Seaman; Beatrix Ueberheide; Klara Velinzon; Bruce D Walker; Thiago Y K Oliveira; Florencia Pereyra; John Pietzsch; Pascal Poignard; Alexander Abadir; Pamela J Bjorkman; Farid Boulad; Dennis R Burton; Brian T Chait; Ron Diskin; David Fenyo; David D Ho; Arlene Hurley; Florian Klein; Hugo Mouquet; Sunnie Myung; Michel C Nussenzweig
Sequence and structural convergence of broad and potent HIV antibodies that mimic CD4 binding.
Science (New York, N.Y.) 2011;333(6049):1633-7.
2011: Sandhya Vasan; Arlene Hurley; Sarah J Schlesinger; Drew Hannaman; David F Gardiner; Daniel P Dugin; Mar Boente-Carrera; Roselle Vittorino; Marina Caskey; Johanne Andersen; Yaoxing Huang; Josephine H Cox; Tony Tarragona-Fiol; Dilbinder K Gill; Hannah Cheeseman; Lorna Clark; Len Dally; Carol Smith; Claudia Schmidt; Harriet H Park; Jakub T Kopycinski; Jill Gilmour; Patricia Fast; Robert Bernard; David D Ho
In vivo electroporation enhances the immunogenicity of an HIV-1 DNA vaccine candidate in healthy volunteers.
PloS one 2011;6(5):e19252.
2010: Sandhya Vasan; Sarah J Schlesinger; Yaoxing Huang; Arlene Hurley; Angela Lombardo; Zhiwei Chen; Soe Than; Phumla Adesanya; Catherine Bunce; Mark Boaz; Rosanne Boyle; Eddy Sayeed; Lorna Clark; Daniel Dugin; Claudia Schmidt; Yang Song; Laura Seamons; Len Dally; Martin Ho; Carol Smith; Martin Markowitz; Josephine Cox; Dilbinder K Gill; Jill Gilmour; Michael C Keefer; Patricia Fast; David D Ho
Phase 1 safety and immunogenicity evaluation of ADVAX, a multigenic, DNA-based clade C/B' HIV-1 candidate vaccine.
PloS one 2010;5(1):e8617.
2004: Saurabh Mehandru; Terri Wrin; Justin Galovich; Gabriela Stiegler; Brigitta Vcelar; Arlene Hurley; Christine Hogan; Sandhya Vasan; Hermann Katinger; Christos J Petropoulos; Martin Markowitz
Neutralization profiles of newly transmitted human immunodeficiency virus type 1 by monoclonal antibodies 2G12, 2F5, and 4E10.
Journal of virology 2004;78(24):14039-42.
2004: Michele Di Mascio; Martin Markowitz; Michael Louie; Arlene Hurley; Christine Hogan; Viviana Simon; dean follmann; David D Ho; Alan S Perelson
Dynamics of intermittent viremia during highly active antiretroviral therapy in patients who initiate therapy during chronic versus acute and early human immunodeficiency virus type 1 infection.
Journal of virology 2004;78(19):10566-73.
2004: Saurabh Mehandru; Michael A Poles; Klara Tenner-Racz; Amir Horowitz; Arlene Hurley; Christine Hogan; Daniel Boden; Paul Racz; Martin Markowitz
Primary HIV-1 infection is associated with preferential depletion of CD4+ T lymphocytes from effector sites in the gastrointestinal tract.
The Journal of experimental medicine 2004;200(6):761-70.
2004: Bharat Ramratnam; Ruy Ribeiro; Tian He; Chris Chung; Viviana Simon; Jeroen Vanderhoeven; Arlene Hurley; Linqi Zhang; Alan S Perelson; David D Ho; Martin Markowitz
Intensification of antiretroviral therapy accelerates the decay of the HIV-1 latent reservoir and decreases, but does not eliminate, ongoing virus replication.
Journal of acquired immune deficiency syndromes (1999) 2004;35(1):33-7.
2003: Michele Di Mascio; Martin Markowitz; Michael Louie; Christine Hogan; Arlene Hurley; Chris Chung; David D Ho; Alan S Perelson
Viral blip dynamics during highly active antiretroviral therapy.
Journal of virology 2003;77(22):12165-72.
2003: Michael A Poles; Shady Barsoum; Wenjie Yu; Jian Yu; Patricia Sun; Jeanine Daly; Tian He; Saurabh Mehandru; Andrew H Talal; Martin Markowitz; Arlene Hurley; David Ho; Linqi Zhang
Human immunodeficiency virus type 1 induces persistent changes in mucosal and blood gammadelta T cells despite suppressive therapy.
Journal of virology 2003;77(19):10456-67.
2003: Neal Padte; Leslie Rowe; Arlene Hurley; Viviana Simon; Martin Markowitz
Sustained viremia during highly active antiretroviral therapy with accelerated proviral DNA decay in the setting of infection with syphilis.
AIDS (London, England) 2003;17(14):2143-5.
2003: Michael Louie; Christine Hogan; Arlene Hurley; Viviana Simon; Chris Chung; Neal Padte; Patrick Lamy; John Flaherty; Dion Coakley; Michele Di Mascio; Alan S Perelson; Martin Markowitz
Determining the antiviral activity of tenofovir disoproxil fumarate in treatment-naive chronically HIV-1-infected individuals.
AIDS (London, England) 2003;17(8):1151-6.
2003: Martin Markowitz; Michael Louie; Arlene Hurley; Eugene Sun; Michele Di Mascio; Alan S Perelson; David D Ho
A novel antiviral intervention results in more accurate assessment of human immunodeficiency virus type 1 replication dynamics and T-cell decay in vivo.
Journal of virology 2003;77(8):5037-8.
2003: Michael Louie; Christine Hogan; Michele Di Mascio; Arlene Hurley; Viviana Simon; James Rooney; Nancy Ruiz; Scott C Brun; Eugene Sun; Alan S Perelson; David D Ho; Martin Markowitz
Determining the relative efficacy of highly active antiretroviral therapy.
The Journal of infectious diseases 2003;187(6):896-900.
2002: Martin Markowitz; Xia Jin; Arlene Hurley; Viviana Simon; Bharat Ramratnam; Michael Louie; Geoffrey R Deschenes; Murugappan Ramanathan; Shady Barsoum; Jeroen Vanderhoeven; Tian He; Chris Chung; John Murray; Alan S Perelson; Linqi Zhang; David D Ho
Discontinuation of antiretroviral therapy commenced early during the course of human immunodeficiency virus type 1 infection, with or without adjunctive vaccination.
The Journal of infectious diseases 2002;186(5):634-43.
2002: Viviana Simon; Jeroen Vanderhoeven; Arlene Hurley; Bharat Ramratnam; Michael Louie; Keith Dawson; Neil Parkin; Daniel Boden; Martin Markowitz
Evolving patterns of HIV-1 resistance to antiretroviral agents in newly infected individuals.
AIDS (London, England) 2002;16(11):1511-9.
2002: Xia Jin; Murugappan Ramanathan; Shady Barsoum; Geoffrey R Deschenes; Lei Ba; James M Binley; Daryl Schiller; Daniel E Bauer; Donald C Chen; Arlene Hurley; Lucette Gebuhrer; Raphaelle El Habib; Pierre Caudrelier; Michel Klein; Linqi Zhang; David D Ho; Martin Markowitz
Safety and immunogenicity of ALVAC vCP1452 and recombinant gp160 in newly human immunodeficiency virus type 1-infected patients treated with prolonged highly active antiretroviral therapy.
Journal of virology 2002;76(5):2206-16.
2001: H Mohri; Alan S Perelson; K Tung; R M Ribeiro; Bharat Ramratnam; Martin Markowitz; Rhonda Kost; Arlene Hurley; L Weinberger; Denise Cesar; Marc K Hellerstein; David D Ho
Increased turnover of T lymphocytes in HIV-1 infection and its reduction by antiretroviral therapy.
The Journal of experimental medicine 2001;194(9):1277-87.
2001: Rhonda Kost; Arlene Hurley; Linqi Zhang; Mika S Vesanen; Andrew H Talal; S Furlan; P Caldwell; J Johnson; L Smiley; D Ho; Martin Markowitz
Open-label phase II trial of amprenavir, abacavir, and fixed-dose zidovudine/lamivudine in newly and chronically HIV-1--infected patients.
Journal of acquired immune deficiency syndromes (1999) 2001;26(4):332-9.
2001: Andrew H Talal; SP Monard; Mika S Vesanen; Z Zheng; Arlene Hurley; Yunzhen Cao; F Fang; L Smiley; J Johnson; Rhonda Kost; MH Markowitz
Virologic and immunologic effect of antiretroviral therapy on HIV-1 in gut-associated lymphoid tissue.
Journal of acquired immune deficiency syndromes (1999) 2001;26(1):1-7.
2000: Linqi Zhang; Chris Chung; B S Hu; Tian He; Y Guo; A J Kim; Eva Skulsky; Xia Jin; Arlene Hurley; Bharat Ramratnam; Martin Markowitz; David D Ho
Genetic characterization of rebounding HIV-1 after cessation of highly active antiretroviral therapy.
The Journal of clinical investigation 2000;106(7):839-45.
2000: James M Binley; Alexandra Trkola; Thomas J Ketas; Daryl Schiller; BA Clas; S Little; D Richman; Arlene Hurley; Martin Markowitz; John P Moore
The effect of highly active antiretroviral therapy on binding and neutralizing antibody responses to human immunodeficiency virus type 1 infection.
The Journal of infectious diseases 2000;182(3):945-9.
2000: James M Binley; Daryl Schiller; G M Ortiz; Arlene Hurley; Douglas F Nixon; Martin Markowitz; John P Moore
The relationship between T cell proliferative responses and plasma viremia during treatment of human immunodeficiency virus type 1 infection with combination antiretroviral therapy.
The Journal of infectious diseases 2000;181(4):1249-63.
2000: Daryl Schiller; James M Binley; Kenneth H Roux; Catherine S Adamson; Ian M Jones; H G Krausslich; Arlene Hurley; Martin Markowitz; John P Moore
Parameters influencing measurement of the Gag antigen-specific T-proliferative response to HIV type 1 infection.
AIDS research and human retroviruses 2000;16(3):259-71.
2000: Bharat Ramratnam; J E Mittler; Linqi Zhang; Daniel Boden; Arlene Hurley; F Fang; CA Macken; Alan S Perelson; Martin Markowitz; David D Ho
The decay of the latent reservoir of replication-competent HIV-1 is inversely correlated with the extent of residual viral replication during prolonged anti-retroviral therapy.
Nature medicine 2000;6(1):82-5.
1999: Bharat Ramratnam; Sebastian Bonhoeffer; James M Binley; Arlene Hurley; Linqi Zhang; J E Mittler; Martin Markowitz; J P Moore; Alan S Perelson; David D Ho
Rapid production and clearance of HIV-1 and hepatitis C virus assessed by large volume plasma apheresis.
Lancet 1999;354(9192):1782-5.
1999: Daniel Boden; Arlene Hurley; Linqi Zhang; Y Cao; Y Guo; E Jones; J Tsay; JE Ip; C Farthing; K Limoli; Neil Parkin; Martin Markowitz
HIV-1 drug resistance in newly infected individuals.
JAMA : the journal of the American Medical Association 1999;282(12):1135-41.
1999: G M Ortiz; Douglas F Nixon; Alexandra Trkola; James M Binley; Xia Jin; Sebastian Bonhoeffer; P J Kuebler; Sean M Donahoe; MA Demoitie; WM Kakimoto; Thomas J Ketas; BA Clas; J J Heymann; Linqi Zhang; Yunzhen Cao; Arlene Hurley; John P Moore; David D Ho; Martin Markowitz
HIV-1-specific immune responses in subjects who temporarily contain virus replication after discontinuation of highly active antiretroviral therapy.
The Journal of clinical investigation 1999;104(6):R13-8.
1999: Sharon R Lewin; Mika S Vesanen; Leondios G Kostrikis; Arlene Hurley; M Duran; Linqi Zhang; David D Ho; Martin Markowitz
Use of real-time PCR and molecular beacons to detect virus replication in human immunodeficiency virus type 1-infected individuals on prolonged effective antiretroviral therapy.
Journal of virology 1999;73(7):6099-103.
1999: Martin Markowitz; Mika S Vesanen; Klara Tenner-Racz; Yunzhen Cao; James M Binley; Andrew H Talal; Arlene Hurley; Xia Jin; M R Chaudhry; M Yaman; S Frankel; ME Heath-Chiozzi; JM Leonard; John P Moore; Paul Racz; Douglas F Nixon; David D Ho; X J
The effect of commencing combination antiretroviral therapy soon after human immunodeficiency virus type 1 infection on viral replication and antiviral immune responses.
The Journal of infectious diseases 1999;179(3):527-37.
1999: Graham S Ogg; X Jin; Sebastian Bonhoeffer; P Moss; M A Nowak; SP Monard; J P Segal; Yunzhen Cao; Sarah L Rowland-Jones; Arlene Hurley; MH Markowitz; David D Ho; Andrew J McMichael; Douglas F Nixon
Decay kinetics of human immunodeficiency virus-specific effector cytotoxic T lymphocytes after combination antiretroviral therapy.
Journal of virology 1999;73(1):797-800.
1998: L Morris; James M Binley; BA Clas; Sebastian Bonhoeffer; T P Astill; Rhonda Kost; Arlene Hurley; Yunzhen Cao; Martin Markowitz; David D Ho; John P Moore
HIV-1 antigen-specific and -nonspecific B cell responses are sensitive to combination antiretroviral therapy.
The Journal of experimental medicine 1998;188(2):233-45.
1998: Martin Markowitz; Marcus Conant; Arlene Hurley; Rosemary P Schluger; M Duran; J Peterkin; S Chapman; A Patick; A Hendricks; G J Yuen; W Hoskins; NJ Clendeninn; David D Ho
A preliminary evaluation of nelfinavir mesylate, an inhibitor of human immunodeficiency virus (HIV)-1 protease, to treat HIV infection.
The Journal of infectious diseases 1998;177(6):1533-40.
1998: Graham S Ogg; X Jin; Sebastian Bonhoeffer; P R Dunbar; M A Nowak; SP Monard; J P Segal; Yunzhen Cao; Sarah L Rowland-Jones; Vincenzo Cerundolo; Arlene Hurley; MH Markowitz; David D Ho; Douglas F Nixon; Andrew J McMichael
Quantitation of HIV-1-specific cytotoxic T lymphocytes and plasma load of viral RNA.
Science (New York, N.Y.) 1998;279(5359):2103-6.
1997: Alan S Perelson; P Essunger; Yunzhen Cao; Mika S Vesanen; Arlene Hurley; K Saksela; Martin Markowitz; David D Ho
Decay characteristics of HIV-1-infected compartments during combination therapy.
Nature 1997;387(6629):188-91.
1995: Martin Markowitz; M Saag; W G Powderly; Arlene Hurley; Ann Hsu; J M Valdes; D Henry; F Sattler; A La Marca; J M Leonard
A preliminary study of ritonavir, an inhibitor of HIV-1 protease, to treat HIV-1 infection.
The New England journal of medicine 1995;333(23):1534-9.