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Laurence Hurley

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Chemicals & Drugs

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Magnetic Resonance Spectroscopy

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Co-Publications
Name
32
Sun, Daekyu
15
Von Hoff, Daniel
13
Han, Haiyong
9
Bearss, David
8
Gleason-Guzman, Mary
8
Vankayalapati, Hariprasad
7
Gokhale, Vijay
7
Izbicka, Elzbieta
6
Kerwin, Sean
6
Kim, Mu-Yong
6
Kwok, Y
5
Siddiqui-Jain, Adam
5
Rezler, Evonne
5
Salazar, Miguel
5
Ebbinghaus, Scot

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Publications

TOP 3
Palumbo SunMi L; Ebbinghaus Scot W; Hurley Laurence H
Formation of a unique end-to-end stacked pair of G-quadruplexes in the hTERT core promoter with implications for inhibition of telomerase by G-quadruplex-interactive ligands.
Hahn Tobias; Fried Karen; Hurley Laurence H; Akporiaye Emmanuel T
Orally active alpha-tocopheryloxyacetic acid suppresses tumor growth and multiplicity of spontaneous murine breast cancer.
Dai Jixun; Ambrus Attila; Hurley Laurence H; Yang Danzhou
A direct and nondestructive approach to determine the folding structure of the I-motif DNA secondary structure by NMR.

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All Publications

2009: Palumbo SunMi L; Ebbinghaus Scot W; Hurley Laurence H
Formation of a unique end-to-end stacked pair of G-quadruplexes in the hTERT core promoter with implications for inhibition of telomerase by G-quadruplex-interactive ligands.
Journal of the American Chemical Society 2009;131(31):10878-91.
2009: Hahn Tobias; Fried Karen; Hurley Laurence H; Akporiaye Emmanuel T
Orally active alpha-tocopheryloxyacetic acid suppresses tumor growth and multiplicity of spontaneous murine breast cancer.
Molecular cancer therapeutics 2009;8(6):1570-8.
2009: Dai Jixun; Ambrus Attila; Hurley Laurence H; Yang Danzhou
A direct and nondestructive approach to determine the folding structure of the I-motif DNA secondary structure by NMR.
Journal of the American Chemical Society 2009;131(17):6102-4.
2009: Sun Daekyu; Hurley Laurence H
The importance of negative superhelicity in inducing the formation of G-quadruplex and i-motif structures in the c-Myc promoter: implications for drug targeting and control of gene expression.
Journal of medicinal chemistry 2009;52(9):2863-74.
2009: Henderson Meredith C; Shaw Yeng-Jeng Y; Wang Hong; Han Haiyong; Hurley Laurence H; Flynn Gary; Dorr Robert T; Von Hoff Daniel D
UA62784, a novel inhibitor of centromere protein E kinesin-like protein.
Molecular cancer therapeutics 2009;8(1):36-44.
2008: Carey Steven S; Gleason-Guzman Mary; Gokhale Vijay; Hurley Laurence H
Psorospermin structural requirements for P-glycoprotein resistance reversal.
Molecular cancer therapeutics 2008;7(11):3617-23.
2008: Guo Kexiao; Gokhale Vijay; Hurley Laurence H; Sun Daekyu
Intramolecularly folded G-quadruplex and i-motif structures in the proximal promoter of the vascular endothelial growth factor gene.
Nucleic acids research 2008;36(14):4598-608.
2008: Qin Yong; Hurley Laurence H
Structures, folding patterns, and functions of intramolecular DNA G-quadruplexes found in eukaryotic promoter regions.
Biochimie 2008;90(8):1149-71.
2008: Sun Daekyu; Liu Wei-Jun; Guo Kexiao; Rusche Jadrian J; Ebbinghaus Scot; Gokhale Vijay; Hurley Laurence H
The proximal promoter region of the human vascular endothelial growth factor gene has a G-quadruplex structure that can be targeted by G-quadruplex-interactive agents.
Molecular cancer therapeutics 2008;7(4):880-9.
2008: Palumbo SunMi L; Memmott Regan M; Uribe Diana J; Krotova-Khan Yulia; Hurley Laurence H; Ebbinghaus Scot W
A novel G-quadruplex-forming GGA repeat region in the c-myb promoter is a critical regulator of promoter activity.
Nucleic acids research 2008;36(6):1755-69.
2008: Cashman Derek J; Buscaglia Robert; Freyer Matthew W; Dettler Jamie; Hurley Laurence H; Lewis Edwin A
Molecular modeling and biophysical analysis of the c-MYC NHE-III1 silencer element.
Journal of molecular modeling 2008;14(2):93-101.
2007: Guo Kexiao; Pourpak Alan; Beetz-Rogers Kara; Gokhale Vijay; Sun Daekyu; Hurley Laurence H
Formation of pseudosymmetrical G-quadruplex and i-motif structures in the proximal promoter region of the RET oncogene.
Journal of the American Chemical Society 2007;129(33):10220-8.
2007: Zhu Ming; Gokhale Vijay M; Szabo Lajos; Munoz Ruben M; Baek Hyounggee; Bashyam Sridevi; Hurley Laurence H; Von Hoff Daniel D; Han Haiyong
Identification of a novel inhibitor of urokinase-type plasminogen activator.
Molecular cancer therapeutics 2007;6(4):1348-56.
2007: Freyer Matthew W; Buscaglia Robert; Kaplan Kimberly; Cashman Derek; Hurley Laurence H; Lewis Edwin A
Biophysical studies of the c-MYC NHE III1 promoter: model quadruplex interactions with a cationic porphyrin.
Biophysical journal 2007;92(6):2007-15.
2007: Qin Yong; Rezler Evonne M; Gokhale Vijay; Sun Daekyu; Hurley Laurence H
Characterization of the G-quadruplexes in the duplex nuclease hypersensitive element of the PDGF-A promoter and modulation of PDGF-A promoter activity by TMPyP4.
Nucleic acids research 2007;35(22):7698-713.
2006: Warner Steven L; Munoz Ruben M; Stafford Phillip; Koller Erich; Hurley Laurence H; Von Hoff Daniel D; Han Haiyong
Comparing Aurora A and Aurora B as molecular targets for growth inhibition of pancreatic cancer cells.
Molecular cancer therapeutics 2006;5(10):2450-8.
2006: Hahn Tobias; Szabo Lajos; Gold Mikhal; Ramanathapuram Lalitha; Hurley Laurence H; Akporiaye Emmanuel T
Dietary administration of the proapoptotic vitamin E analogue alpha-tocopheryloxyacetic acid inhibits metastatic murine breast cancer.
Cancer research 2006;66(19):9374-8.
2006: Hurley Laurence H; Von Hoff Daniel D; Siddiqui-Jain Adam; Yang Danzhou
Drug targeting of the c-MYC promoter to repress gene expression via a G-quadruplex silencer element.
Seminars in oncology 2006;33(4):498-512.
2006: Warner Steven L; Bashyam Sridevi; Vankayalapati Hariprasad; Bearss David J; Han Haiyong; Mahadevan Daruka; Von Hoff Daniel D; Hurley Laurence H
Identification of a lead small-molecule inhibitor of the Aurora kinases using a structure-assisted, fragment-based approach.
Molecular cancer therapeutics 2006;5(7):1764-73.
2006: Dexheimer Thomas S; Sun Daekyu; Hurley Laurence H
Deconvoluting the structural and drug-recognition complexity of the G-quadruplex-forming region upstream of the bcl-2 P1 promoter.
Journal of the American Chemical Society 2006;128(16):5404-15.
2006: Dai Jixun; Chen Ding; Jones Roger A; Hurley Laurence H; Yang Danzhou
NMR solution structure of the major G-quadruplex structure formed in the human BCL2 promoter region.
Nucleic acids research 2006;34(18):5133-44.
2006: Yang Danzhou; Hurley Laurence H
Structure of the biologically relevant G-quadruplex in the c-MYC promoter.
Nucleosides, nucleotides & nucleic acids 2006;25(8):951-68.
2005: De Armond Richard; Wood Stacey; Sun Daekyu; Hurley Laurence H; Ebbinghaus Scot W
Evidence for the presence of a guanine quadruplex forming region within a polypurine tract of the hypoxia inducible factor 1alpha promoter.
Biochemistry 2005;44(49):16341-50.
2005: Gerner Eugene W; Ignatenko Natalia A; Lance Peter; Hurley Laurence H
A comprehensive strategy to combat colon cancer targeting the adenomatous polyposis coli tumor suppressor gene.
Annals of the New York Academy of Sciences 2005;1059():97-105.
2005: Fellows Ingrid M; Schwaebe Michael; Dexheimer Thomas S; Vankayalapati Hariprasad; Gleason-Guzman Mary; Whitten Jeffrey P; Hurley Laurence H
Determination of the importance of the stereochemistry of psorospermin in topoisomerase II-induced alkylation of DNA and in vitro and in vivo biological activity.
Molecular cancer therapeutics 2005;4(11):1729-39.
2005: Rezler Evonne M; Seenisamy Jeyaprakashnarayanan; Bashyam Sridevi; Kim Mu-Yong; White Elizabeth; Wilson W David; Hurley Laurence H
Telomestatin and diseleno sapphyrin bind selectively to two different forms of the human telomeric G-quadruplex structure.
Journal of the American Chemical Society 2005;127(26):9439-47.
2005: Heald Robert A; Dexheimer Thomas S; Vankayalapati Hariprasad; Siddiqui-Jain Adam; Szabo Lajos Z; Gleason-Guzman Mary C; Hurley Laurence H
Conformationally restricted analogues of psorospermin: design, synthesis, and bioactivity of natural-product-related bisfuranoxanthones.
Journal of medicinal chemistry 2005;48(8):2993-3004.
2005: Seenisamy Jeyaprakashnarayanan; Bashyam Sridevi; Gokhale Vijay; Vankayalapati Hariprasad; Sun Daekyu; Siddiqui-Jain Adam; Streiner Nicole; Shin-Ya Kazuo; White Elizabeth; Wilson W David; Hurley Laurence H
Design and synthesis of an expanded porphyrin that has selectivity for the c-MYC G-quadruplex structure.
Journal of the American Chemical Society 2005;127(9):2944-59.
2005: Grand Cory L; Powell Tiffanie J; Nagle Raymond B; Bearss David J; Tye Denise; Gleason-Guzman Mary; Hurley Laurence H
Mutations in the G-quadruplex silencer element and their relationship to c-MYC overexpression, NM23 repression, and therapeutic rescue.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(2):516.
2005: Liu Weijun; Sun Daekyu; Hurley Laurence H
Binding of G-quadruplex-interactive agents to distinct G-quadruplexes induces different biological effects in MiaPaCa cells.
Nucleosides, nucleotides & nucleic acids 2005;24(10-12):1801-15.
2005: Sun Daekyu; Guo Kexiao; Rusche Jadrian J; Hurley Laurence H
Facilitation of a structural transition in the polypurine/polypyrimidine tract within the proximal promoter region of the human VEGF gene by the presence of potassium and G-quadruplex-interactive agents.
Nucleic acids research 2005;33(18):6070-80.
2004: Zhilina Zhanna V; Ziemba Amy J; Trent John O; Reed Michael W; Gorn Vladimir; Zhou Qun; Duan Wenhu; Hurley Laurence; Ebbinghaus Scot W
Synthesis and evaluation of a triplex-forming oligonucleotide-pyrrolobenzodiazepine conjugate.
Bioconjugate chemistry 2004;15(6):1182-92.
2004: Mehta Anil K; Shayo Yuda; Vankayalapati Hariprasad; Hurley Laurence H; Schaefer Jacob
Structure of a quinobenzoxazine--G-quadruplex complex by REDOR NMR.
Biochemistry 2004;43(38):11953-8.
2004: Seenisamy Jeyaprakashnarayanan; Rezler Evonne M; Powell Tiffanie J; Tye Denise; Gokhale Vijay; Joshi Chandana Sharma; Siddiqui-Jain Adam; Hurley Laurence H
The dynamic character of the G-quadruplex element in the c-MYC promoter and modification by TMPyP4.
Journal of the American Chemical Society 2004;126(28):8702-9.
2004: Grand Cory L; Powell Tiffanie J; Nagle Raymond B; Bearss David J; Tye Denise; Gleason-Guzman Mary; Hurley Laurence H
Mutations in the G-quadruplex silencer element and their relationship to c-MYC overexpression, NM23 repression, and therapeutic rescue.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(16):6140-5.
2004: Shammas Masood A; Shmookler Reis Robert J; Li Cheng; Koley Hemanta; Hurley Laurence H; Anderson Kenneth C; Munshi Nikhil C
Telomerase inhibition and cell growth arrest after telomestatin treatment in multiple myeloma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(2):770-6.
2003: Shammas Masood A; Shmookler Reis Robert J; Akiyama Masaharu; Koley Hemanta; Chauhan Dharminder; Hideshima Teru; Goyal Raj K; Hurley Laurence H; Anderson Kenneth C; Munshi Nikhil C
Telomerase inhibition and cell growth arrest by G-quadruplex interactive agent in multiple myeloma.
Molecular cancer therapeutics 2003;2(9):825-33.
2003: Weisman-Shomer Pnina; Cohen Esther; Hershco Inbal; Khateb Samer; Wolfovitz-Barchad Orit; Hurley Laurence H; Fry Michael
The cationic porphyrin TMPyP4 destabilizes the tetraplex form of the fragile X syndrome expanded sequence d(CGG)n.
Nucleic acids research 2003;31(14):3963-70.
2003: Kim Mu-Yong; Na Younghwa; Vankayalapati Hariprasad; Gleason-Guzman Mary; Hurley Laurence H
Design, synthesis, and evaluation of psorospermin/quinobenzoxazine hybrids as structurally novel antitumor agents.
Journal of medicinal chemistry 2003;46(14):2958-72.
2003: Kim Mu-Yong; Gleason-Guzman Mary; Izbicka Elzbieta; Nishioka David; Hurley Laurence H
The different biological effects of telomestatin and TMPyP4 can be attributed to their selectivity for interaction with intramolecular or intermolecular G-quadruplex structures.
Cancer research 2003;63(12):3247-56.
2003: Kim Mu-Yong; Duan Wenhu; Gleason-Guzman Mary; Hurley Laurence H
Design, synthesis, and biological evaluation of a series of fluoroquinoanthroxazines with contrasting dual mechanisms of action against topoisomerase II and G-quadruplexes.
Journal of medicinal chemistry 2003;46(4):571-83.
2003: Rezler Evonne M; Bearss David J; Hurley Laurence H
Telomere inhibition and telomere disruption as processes for drug targeting.
Annual review of pharmacology and toxicology 2003;43():359-79.
2002: Siddiqui-Jain Adam; Grand Cory L; Bearss David J; Hurley Laurence H
Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-MYC transcription.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(18):11593-8.
2002: Rezler Evonne M; Bearss David J; Hurley Laurence H
Telomeres and telomerases as drug targets.
Current opinion in pharmacology 2002;2(4):415-23.
2002: Grand Cory L; Han Haiyong; Muñoz Rubén M; Weitman Steve; Von Hoff Daniel D; Hurley Laurence H; Bearss David J
The cationic porphyrin TMPyP4 down-regulates c-MYC and human telomerase reverse transcriptase expression and inhibits tumor growth in vivo.
Molecular cancer therapeutics 2002;1(8):565-73.
2002: Hurley Laurence H
DNA and its associated processes as targets for cancer therapy.
Nature reviews. Cancer 2002;2(3):188-200.
2002: Kim Mu-Yong; Vankayalapati Hariprasad; Shin-Ya Kazuo; Wierzba Konstanty; Hurley Laurence H
Telomestatin, a potent telomerase inhibitor that interacts quite specifically with the human telomeric intramolecular g-quadruplex.
Journal of the American Chemical Society 2002;124(10):2098-9.
2002: Herzig Maryanne C S; Rodriguez Karl A; Trevino Alex V; Dziegielewski Jaroslaw; Arnett Brenda; Hurley Laurence; Woynarowski Jan M
The genome factor in region-specific DNA damage: the DNA-reactive drug U-78779 prefers mixed A/T-G/C sequences at the nucleotide level but is region-specific for long pure AT islands at the genomic level.
Biochemistry 2002;41(5):1545-55.
2001: Duan W; Rangan A; Vankayalapati H; Kim M Y; Zeng Q; Sun D; Han H; Fedoroff O Y; Nishioka D; Rha S Y; Izbicka E; Von Hoff D D; Hurley L H
Design and synthesis of fluoroquinophenoxazines that interact with human telomeric G-quadruplexes and their biological effects.
Molecular cancer therapeutics 2001;1(2):103-20.
2001: Shi D F; Wheelhouse R T; Sun D; Hurley L H
Quadruplex-interactive agents as telomerase inhibitors: synthesis of porphyrins and structure-activity relationship for the inhibition of telomerase.
Journal of medicinal chemistry 2001;44(26):4509-23.
2001: Zewail-Foote M; Li V S; Kohn H; Bearss D; Guzman M; Hurley L H
The inefficiency of incisions of ecteinascidin 743-DNA adducts by the UvrABC nuclease and the unique structural feature of the DNA adducts can be used to explain the repair-dependent toxicities of this antitumor agent.
Chemistry & biology 2001;8(11):1033-49.
2001: Hurley L H
Secondary DNA structures as molecular targets for cancer therapeutics.
Biochemical Society transactions 2001;29(Pt 6):692-6.
2001: Han H; Langley D R; Rangan A; Hurley L H
Selective interactions of cationic porphyrins with G-quadruplex structures.
Journal of the American Chemical Society 2001;123(37):8902-13.
2001: Zewail-Foote M; Hurley L H
Differential rates of reversibility of ecteinascidin 743-DNA covalent adducts from different sequences lead to migration to favored bonding sites.
Journal of the American Chemical Society 2001;123(27):6485-95.
2001: Zhou Q; Duan W; Simmons D; Shayo Y; Raymond M A; Dorr R T; Hurley L H
Design and synthesis of a novel DNA-DNA interstrand adenine-guanine cross-linking agent.
Journal of the American Chemical Society 2001;123(20):4865-6.
2001: Rangan A; Fedoroff O Y; Hurley L H
Induction of duplex to G-quadruplex transition in the c-myc promoter region by a small molecule.
The Journal of biological chemistry 2001;276(7):4640-6.
2001: Hurley L H; Zewail-Foote M
The antitumor agent ecteinascidin 743: characterization of its covalent DNA adducts and chemical stability.
Advances in experimental medicine and biology 2001;500():289-99.
2001: Sun D; Hurley L H
Targeting telomeres and telomerase.
Methods in enzymology 2001;340():573-92.
2000: Bearss D J; Hurley L H; Von Hoff D D
Telomere maintenance mechanisms as a target for drug development.
Oncogene 2000;19(56):6632-41.
2000: Fedoroff O Y; Rangan A; Chemeris V V; Hurley L H
Cationic porphyrins promote the formation of i-motif DNA and bind peripherally by a nonintercalative mechanism.
Biochemistry 2000;39(49):15083-90.
2000: Yu H; Kwok Y; Hurley L H; Kerwin S M
Efficient, Mg(2+)-dependent photochemical DNA cleavage by the antitumor quinobenzoxazine (S)-A-62176.
Biochemistry 2000;39(33):10236-46.
2000: Han H; Bennett R J; Hurley L H
Inhibition of unwinding of G-quadruplex structures by Sgs1 helicase in the presence of N,N'-bis[2-(1-piperidino)ethyl]-3,4,9,10-perylenetetracarboxylic diimide, a G-quadruplex-interactive ligand.
Biochemistry 2000;39(31):9311-6.
2000: Raymond E; Soria J C; Izbicka E; Boussin F; Hurley L; Von Hoff D D
DNA G-quadruplexes, telomere-specific proteins and telomere-associated enzymes as potential targets for new anticancer drugs.
Investigational new drugs 2000;18(2):123-37.
2000: Han H; Hurley L H
G-quadruplex DNA: a potential target for anti-cancer drug design.
Trends in pharmacological sciences 2000;21(4):136-42.
2000: Rha S Y; Izbicka E; Lawrence R; Davidson K; Sun D; Moyer M P; Roodman G D; Hurley L; Von Hoff D
Effect of telomere and telomerase interactive agents on human tumor and normal cell lines.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(3):987-93.
2000: Hurley L H; Wheelhouse R T; Sun D; Kerwin S M; Salazar M; Fedoroff O Y; Han F X; Han H; Izbicka E; Von Hoff D D
G-quadruplexes as targets for drug design.
Pharmacology & therapeutics 2000;85(3):141-58.
1999: Kwok Y; Sun D; Clement J J; Hurley L H
The quinobenzoxazines: relationship between DNA binding and biological activity.
Anti-cancer drug design 1999;14(5):443-50.
1999: Cathers B E; Sun D; Hurley L H
Accurate determination of quadruplex binding affinity and potency of G-quadruplex-interactive telomerase inhibitors by use of a telomerase extension assay requires varying the primer concentration.
Anti-cancer drug design 1999;14(4):367-72.
1999: Izbicka E; Nishioka D; Marcell V; Raymond E; Davidson K K; Lawrence R A; Wheelhouse R T; Hurley L H; Wu R S; Von Hoff D D
Telomere-interactive agents affect proliferation rates and induce chromosomal destabilization in sea urchin embryos.
Anti-cancer drug design 1999;14(4):355-65.
1999: Zewail-Foote M; Hurley L H
Ecteinascidin 743: a minor groove alkylator that bends DNA toward the major groove.
Journal of medicinal chemistry 1999;42(14):2493-7.
1999: Kwok Y; Zeng Q; Hurley L H
Structural insight into a quinolone-topoisomerase II-DNA complex. Further evidence for a 2:2 quinobenzoxazine-mg2+ self-assembly model formed in the presence of topoisomerase ii.
The Journal of biological chemistry 1999;274(24):17226-35.
1999: Han H; Cliff C L; Hurley L H
Accelerated assembly of G-quadruplex structures by a small molecule.
Biochemistry 1999;38(22):6981-6.
1999: Sun D; Lopez-Guajardo C C; Quada J; Hurley L H; Von Hoff D D
Regulation of catalytic activity and processivity of human telomerase.
Biochemistry 1999;38(13):4037-44.
1999: Zewail-Foote M; Hurley L H
Molecular approaches to achieving control of gene expression by drug intervention at the transcriptional level.
Anti-cancer drug design 1999;14(1):1-9.
1999: Izbicka E; Wheelhouse R T; Raymond E; Davidson K K; Lawrence R A; Sun D; Windle B E; Hurley L H; Von Hoff D D
Effects of cationic porphyrins as G-quadruplex interactive agents in human tumor cells.
Cancer research 1999;59(3):639-44.
1999: Han H; Hurley L H; Salazar M
A DNA polymerase stop assay for G-quadruplex-interactive compounds.
Nucleic acids research 1999;27(2):537-42.
1998: Sun D; Hurley L H; Von Hoff D D
Telomerase assay using biotinylated-primer extension and magnetic separation of the products.
BioTechniques 1998;25(6):1046-51.
1998: Kwok Y; Hurley L H
Topoisomerase II site-directed alkylation of DNA by psorospermin and its effect on topoisomerase II-mediated DNA cleavage.
The Journal of biological chemistry 1998;273(49):33020-6.
1998: Kwok Y; Zeng Q; Hurley L H
Topoisomerase II-mediated site-directed alkylation of DNA by psorospermin and its use in mapping other topoisomerase II poison binding sites.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(23):13531-6.
1998: Zeng Q; Kwok Y; Kerwin S M; Mangold G; Hurley L H
Design of new topoisomerase II inhibitors based upon a quinobenzoxazine self-assembly model.
Journal of medicinal chemistry 1998;41(22):4273-8.
1998: Fedoroff O Y; Salazar M; Han H; Chemeris V V; Kerwin S M; Hurley L H
NMR-Based model of a telomerase-inhibiting compound bound to G-quadruplex DNA.
Biochemistry 1998;37(36):12367-74.
1998: Fletcher T M; Sun D; Salazar M; Hurley L H
Effect of DNA secondary structure on human telomerase activity.
Biochemistry 1998;37(16):5536-41.
1997: Sun D; Thompson B; Cathers B E; Salazar M; Kerwin S M; Trent J O; Jenkins T C; Neidle S; Hurley L H
Inhibition of human telomerase by a G-quadruplex-interactive compound.
Journal of medicinal chemistry 1997;40(14):2113-6.
1996: Salazar M; Thompson B D; Kerwin S M; Hurley L H
Thermally induced DNA.RNA hybrid to G-quadruplex transitions: possible implications for telomere synthesis by telomerase.
Biochemistry 1996;35(50):16110-5.
1996: Sun D; Hurley L H; Harshey R M
Structural distortions induced by integration host factor (IHF) at the H' site of phage lambda probed by (+)-CC-1065, pluramycin, and KMnO4 and by DNA cyclization studies.
Biochemistry 1996;35(33):10815-27.
1996: Han F X; Hurley L H
A model for the T-antigen-induced structural alteration of the SV40 replication origin based upon experiments with specific probes for bent, straight, and unwound DNA.
Biochemistry 1996;35(24):7993-8001.
1996: Henderson D; Hurley L H
Specific targeting of protein-DNA complexes by DNA-reactive drugs (+)-CC-1065 and pluramycins.
Journal of molecular recognition : JMR 1996;9(2):75-87.
1995: Thompson A S; Fan J Y; Sun D; Hansen M; Hurley L H
Determination of the structural role of the internal guanine-cytosine base pair in recognition of a seven-base-pair sequence cross-linked by bizelesin.
Biochemistry 1995;34(35):11005-16.
1995: Thompson A S; Hurley L H
Solution conformation of a bizelesin A-tract duplex adduct: DNA-DNA cross-linking of an A-tract straightens out bent DNA.
Journal of molecular biology 1995;252(1):86-101.
1995: Sun D; Hurley L H
TBP binding to the TATA box induces a specific downstream unwinding site that is targeted by pluramycin.
Chemistry & biology 1995;2(7):457-69.
1995: Henderson D; Hurley L H
Molecular struggle for transcriptional control.
Nature medicine 1995;1(6):525-7.
1995: Hansen M; Yun S; Hurley L
Hedamycin intercalates the DNA helix and, through carbohydrate-mediated recognition in the minor groove, directs N7-alkylation of guanine in the major groove in a sequence-specific manner.
Chemistry & biology 1995;2(4):229-40.
1995: Fan J Y; Sun D; Yu H; Kerwin S M; Hurley L H
Self-assembly of a quinobenzoxazine-Mg2+ complex on DNA: a new paradigm for the structure of a drug-DNA complex and implications for the structure of the quinolone bacterial gyrase-DNA complex.
Journal of medicinal chemistry 1995;38(3):408-24.
1994: Jenkins T C; Hurley L H; Neidle S; Thurston D E
Structure of a covalent DNA minor groove adduct with a pyrrolobenzodiazepine dimer: evidence for sequence-specific interstrand cross-linking.
Journal of medicinal chemistry 1994;37(26):4529-37.
1994: Sun D; Hurley L H
Binding of Sp1 to the 21-bp repeat region of SV40 DNA: effect of intrinsic and drug-induced DNA bending between GC boxes.
Gene 1994;149(1):165-72.
1994: Mountzouris J A; Wang J J; Thurston D; Hurley L H
Comparison of a DSB-120 DNA interstrand cross-linked adduct with the corresponding bis-tomaymycin adduct: an example of a successful template-directed approach to drug design based upon the monoalkylating compound tomaymycin.
Journal of medicinal chemistry 1994;37(19):3132-40.
1994: Sun D; Hurley L H
Cooperative bending of the 21-base-pair repeats of the SV40 viral early promoter by human Sp1.
Biochemistry 1994;33(32):9578-87.
1994: Hurley L H; Sun D
(+)-CC-1065 as a probe for intrinsic and protein-induced bending of DNA.
Journal of molecular recognition : JMR 1994;7(2):123-32.
1994: Hurley L H
The minor groove covalent reactive drugs anthramycin and (+)-CC-1065 and their interstrand cross-linking derivatives.
IARC scientific publications 1994;(125):295-312.
1993: Seaman F C; Hurley L
Interstrand cross-linking by bizelesin produces a Watson-Crick to Hoogsteen base-pairing transition region in d(CGTAATTACG)2.
Biochemistry 1993;32(47):12577-85.
1993: Sun D; Park H J; Hurley L H
Alkylation of guanine and cytosine in DNA by bizelesin. Evidence for a covalent immobilization leading to a proximity-driven alkylation of normally unreactive bases by a (+)-CC-1065 cross-linking compound.
Chemical research in toxicology 1993;6(6):889-94.
1993: Ding Z M; Harshey R M; Hurley L H
(+)-CC-1065 as a structural probe of Mu transposase-induced bending of DNA: overcoming limitations of hydroxyl-radical footprinting.
Nucleic acids research 1993;21(18):4281-7.
1993: Kizu R; Draves P H; Hurley L H
Correlation of DNA sequence specificity of anthramycin and tomaymycin with reaction kinetics and bending of DNA.
Biochemistry 1993;32(33):8712-22.
1993: Sun D; Hansen M; Clement J J; Hurley L H
Structure of the altromycin B (N7-guanine)-DNA adduct. A proposed prototypic DNA adduct structure for the pluramycin antitumor antibiotics.
Biochemistry 1993;32(32):8068-74.
1993: Aristoff P A; Johnson P D; Sun D; Hurley L H
Synthesis and biochemical evaluation of the CBI-PDE-I-dimer, a benzannelated analog of (+)-CC-1065 that also produces delayed toxicity in mice.
Journal of medicinal chemistry 1993;36(14):1956-63.
1993: Sun D; Lin C H; Hurley L H
A-tract and (+)-CC-1065-induced bending of DNA. Comparison of structural features using non-denaturing gel analysis, hydroxyl-radical footprinting, and high-field NMR.
Biochemistry 1993;32(17):4487-95.
1992: Wang J J; Hill G C; Hurley L H
Template-directed design of a DNA-DNA cross-linker based upon a bis-tomaymycin-duplex adduct.
Journal of medicinal chemistry 1992;35(16):2995-3002.
1992: Sun D; Hurley L H
Structure-activity relationships of (+)-CC-1065 analogues in the inhibition of helicase-catalyzed unwinding of duplex DNA.
Journal of medicinal chemistry 1992;35(10):1773-82.
1992: Maine I P; Sun D; Hurley L H; Kodadek T
The antitumor agent CC-1065 inhibits helicase-catalyzed unwinding of duplex DNA.
Biochemistry 1992;31(16):3968-75.
1992: Sun D; Hurley L H
Effect of the (+)-CC-1065-(N3-adenine)DNA adduct on in vitro DNA synthesis mediated by Escherichia coli DNA polymerase.
Biochemistry 1992;31(10):2822-9.
1992: Lin C H; Hill G C; Hurley L H
Characterization of a 12-mer duplex d(GGCGGAGTTAGG).d(CCTAACTCCGCC) containing a highly reactive (+)-CC-1065 sequence by 1H and 31P NMR, hydroxyl-radical footprinting, and NOESY restrained molecular dynamics calculations.
Chemical research in toxicology 1992;5(2):167-82.
1992: Sun D; Hurley L H
Inhibition of T4 DNA ligase activity by (+)-CC-1065: demonstration of the importance of the stiffening and winding effects of (+)-CC-1065 on DNA.
Anti-cancer drug design 1992;7(1):15-36.
1991: Ding Z M; Hurley L H
DNA interstrand cross-linking, DNA sequence specificity, and induced conformational changes produced by a dimeric analog of (+)-CC-1065.
Anti-cancer drug design 1991;6(5):427-52.
1991: Tang M S; Nazimiec M E; Doisy R P; Pierce J R; Hurley L H; Alderete B E
Repair of helix-stabilizing anthramycin-N2 guanine DNA adducts by UVRA and UVRB proteins.
Journal of molecular biology 1991;220(4):855-66.
1991: Lin C H; Beale J M; Hurley L H
Structure of the (+)-CC-1065-DNA adduct: critical role of ordered water molecules and implications for involvement of phosphate catalysis in the covalent reaction.
Biochemistry 1991;30(15):3597-602.
1991: Lee C S; Sun D; Kizu R; Hurley L H
Determination of the structural features of (+)-CC-1065 that are responsible for bending and winding of DNA.
Chemical research in toxicology 1991;4(2):203-13.
1991: Lin C H; Sun D Y; Hurley L H
(+)-CC-1065 produces bending of DNA that appears to resemble adenine/thymine tracts.
Chemical research in toxicology 1991;4(1):21-6.
1990: Lin C H; Hurley L H
Determination of the major tautomeric form of the covalently modified adenine in the (+)-CC-1065-DNA adduct by 1H and 15N NMR studies.
Biochemistry 1990;29(41):9503-7.
1990: Boyd F L; Stewart D; Remers W A; Barkley M D; Hurley L H
Characterization of a unique tomaymycin-d(CICGAATTCICG)2 adduct containing two drug molecules per duplex by NMR, fluorescence, and molecular modeling studies.
Biochemistry 1990;29(9):2387-403.
1989: Hurley L H
DNA and associated targets for drug design.
Journal of medicinal chemistry 1989;32(9):2027-33.
1988: Hurley L H; Boyd F L
DNA as a target for drug action.
Trends in pharmacological sciences 1988;9(11):402-7.
1988: Warpehoski M A; Hurley L H
Sequence selectivity of DNA covalent modification.
Chemical research in toxicology 1988;1(6):315-33.
1988: Hurley L H; Reck T; Thurston D E; Langley D R; Holden K G; Hertzberg R P; Hoover J R; Gallagher G; Faucette L F; Mong S M
Pyrrolo[1,4]benzodiazepine antitumor antibiotics: relationship of DNA alkylation and sequence specificity to the biological activity of natural and synthetic compounds.
Chemical research in toxicology 1988;1(5):258-68.
1988: Hurley L H; Lee C S; McGovren J P; Warpehoski M A; Mitchell M A; Kelly R C; Aristoff P A
Molecular basis for sequence-specific DNA alkylation by CC-1065.
Biochemistry 1988;27(10):3886-92.
1988: Hurley L H; Lee C S; McGovren J P; Warpehoski M A; Mitchell M A; Kelly R C; Aristoff P A
Reaction of CC-1065 and select synthetic analogs with DNA.
Biochemical pharmacology 1988;37(9):1795-6.
1988: Cheatham S; Kook A; Hurley L H; Barkley M D; Remers W
One- and two-dimensional 1H NMR, fluorescence, and molecular modeling studies on the tomaymycin-d(ATGCAT)2 adduct. Evidence for two covalent adducts with opposite orientations and stereochemistries at the covalent linkage site.
Journal of medicinal chemistry 1988;31(3):583-90.
1988: Tang M S; Lee C S; Doisy R; Ross L; Needham-VanDevanter D R; Hurley L H
Recognition and repair of the CC-1065-(N3-adenine)-DNA adduct by the UVRABC nucleases.
Biochemistry 1988;27(3):893-901.
1987: Hurley L H
Molecular biology and medicinal chemistry.
Journal of medicinal chemistry 1987;30(10):7A-8A.
1987: Hurley L H; Needham-VanDevanter D R; Lee C S
Demonstration of the asymmetric effect of CC-1065 on local DNA structure using a site-directed adduct in a 117-base-pair fragment from M13mp1.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(18):6412-6.
1986: Needham-VanDevanter D R; Hurley L H
Construction and characterization of a site-directed CC-1065-N3-adenine adduct within a 117 base pair DNA restriction fragment.
Biochemistry 1986;25(26):8430-6.
1986: Jacobson M K; Twehous D; Hurley L H
Depletion of nicotinamide adenine dinucleotide in normal and xeroderma pigmentosum fibroblast cells by the antitumor drug CC-1065.
Biochemistry 1986;25(20):5929-32.
1986: Barkley M D; Cheatham S; Thurston D E; Hurley L H
Pyrrolo[1,4]benzodiazepine antitumor antibiotics: evidence for two forms of tomaymycin bound to DNA.
Biochemistry 1986;25(10):3021-31.
1986: Reynolds V L; McGovren J P; Hurley L H
The chemistry, mechanism of action and biological properties of CC-1065, a potent antitumor antibiotic.
The Journal of antibiotics 1986;39(3):319-34.
1986: Hertzberg R P; Hecht S M; Reynolds V L; Molineux I J; Hurley L H
DNA sequence specificity of the pyrrolo[1,4]benzodiazepine antitumor antibiotics. Methidiumpropyl-EDTA-iron(II) footprinting analysis of DNA binding sites for anthramycin and related drugs.
Biochemistry 1986;25(6):1249-58.
1986: Hurley L H; Needham-VanDevanter D R
Sequence specificity and biological consequences of drugs that bind covalently in the minor groove of DNA.
Basic life sciences 1986;38():203-10.
1985: Reynolds V L; Molineux I J; Kaplan D J; Swenson D H; Hurley L H
Reaction of the antitumor antibiotic CC-1065 with DNA. Location of the site of thermally induced strand breakage and analysis of DNA sequence specificity.
Biochemistry 1985;24(22):6228-37.
1984: Hurley L H; Reynolds V L; Swenson D H; Petzold G L; Scahill T A
Reaction of the antitumor antibiotic CC-1065 with DNA: structure of a DNA adduct with DNA sequence specificity.
Science (New York, N.Y.) 1984;226(4676):843-4.
1984: Needham-VanDevanter D R; Hurley L H; Reynolds V L; Theriault N Y; Krueger W C; Wierenga W
Characterization of an adduct between CC-1065 and a defined oligodeoxynucleotide duplex.
Nucleic acids research 1984;12(15):6159-68.
1984: Graves D E; Pattaroni C; Krishnan B S; Ostrander J M; Hurley L H; Krugh T R
The reaction of anthramycin with DNA. Proton and carbon nuclear magnetic resonance studies on the structure of the anthramycin-DNA adduct.
The Journal of biological chemistry 1984;259(13):8202-9.
1983: Hurley L H; Rokem J S
Biosynthesis of the antitumor antibiotic CC-1065 by Streptomyces zelensis.
The Journal of antibiotics 1983;36(4):383-90.
1982: Reynolds V L; Hurley L H
Comparison of properties of the in vitro and cellular anthramycin-DNA adducts and characterization of the reaction of anthramycin with chromatin.
Chemico-biological interactions 1982;42(2):141-51.
1982: Swenson D H; Li L H; Hurley L H; Rokem J S; Petzold G L; Dayton B D; Wallace T L; Lin A H; Krueger W C
Mechanism of interaction of CC-1065 (NSC 298223) with DNA.
Cancer research 1982;42(7):2821-8.
1982: Petrusek R L; Uhlenhopp E L; Duteau N; Hurley L H
Reaction of anthramycin with DNA. Biological consequences of DNA damage in normal and xeroderma pigmentosum cell.
The Journal of biological chemistry 1982;257(11):6207-16.
1981: Kaplan D J; Hurley L H
Anthramycin binding to deoxyribonucleic acid-mitomycin C complexes. Evidence for drug-induced deoxyribonucleic acid conformational change and cooperativity in mitomycin C binding.
Biochemistry 1981;20(26):7572-80.
1981: Rokem J S; Hurley L H
Sensitivity and permeability of the anthramycin producing organism Streptomyces refuineus to anthramycin and structurally related antibiotics.
The Journal of antibiotics 1981;34(9):1171-4.
1981: Petrusek R L; Anderson G L; Garner T F; Fannin Q L; Kaplan D J; Zimmer S G; Hurley L H
Pyrrol[1,4]benzodiazepine antibiotics. Proposed structures and characteristics of the in vitro deoxyribonucleic acid adducts of anthramycin, tomaymycin, sibiromycin, and neothramycins A and B.
Biochemistry 1981;20(5):1111-9.
1981: Malhotra R K; Ostrander J M; Hurley L H; McInnes A G; Smith D G; Walter J A; Wright J L
Chemical conversion of anthramycin 11-methyl ether to didehydroanhydroanthramycin and its utilization in studies of the biosynthesis and mechanism of action of anthramycin.
Journal of natural products 1981;44(1):38-44.
1980: Ostrander J M; Hurley L H; McInnes A G; Smith D G; Walter J A; Wright J L
Proof for the biosynthetic conversion of L-[indole-15N]tryptophan to [10-15N]anthramycin using (13C, 15N) labelling in conjunction with 13C-NMR and mass spectral analysis.
The Journal of antibiotics 1980;33(10):1167-71.
1980: Hurley L H; Rokem J S; Petrusek R L
Proposed structures of the pyrrolo(1,4)benzodiazepine antibiotic-deoxyribonucleic acid adducts.
Biochemical pharmacology 1980;29(9):1307-10.
1980: Hannan M A; Estes R S; Hurley L H
Induction and potentiation of lethal and genetic effects of ultraviolet light by tobacco smoke condensates in yeast.
Environmental research 1980;21(1):97-107.
1980: Lubawy W C; Dallam R A; Hurley L H
Protection against anthramycin-induced toxicity in mice by coenzyme Q10.
Journal of the National Cancer Institute 1980;64(1):105-9.
1979: Hurley L H; Petrusek R
Proposed structure of the anthramycin-DNA adduct.
Nature 1979;282(5738):529-31.
1979: Hurley L H; Lasswell W L; Ostrander J M; Parry R
Pyrrolo[1,4]benzodiazepine antibiotics. Biosynthetic conversion of tyrosine to the C2- and C3-proline moieties of anthramycin, tomaymycin, and sibiromycin.
Biochemistry 1979;18(19):4230-7.
1979: Hurley L H; Lasswell W L; Malhotra R K; Das N V
Pyrrolo[1,4]benzodiazepine antibiotics. Biosynthesis of the antitumor antibiotic sibiromycin by Streptosporangium sibiricum.
Biochemistry 1979;18(19):4225-9.
1979: Hurley L H; Allen C S; Feola J M; Lubawy W C
In vitro and in vivo stability of anthramycin-DNA conjugate and its potential application as an anthramycin prodrug.
Cancer research 1979;39(8):3134-40.
1979: Lubawy W C; Whaley J; Hurley L H
Coenzyme Q10 or alpha-tocopherol reduce the acute toxicity of anthramycin in mice.
Research communications in chemical pathology and pharmacology 1979;24(2):401-4.
1979: Hurley L H; Chandler C; Garner T F; Petrusek R; Zimmer S G
DNA binding, induction of unscheduled DNA synthesis, and excision of anthramycin from DNA in normal and repair-deficient human fibroblasts.
The Journal of biological chemistry 1979;254(3):605-8.
1979: Hurley L H; Gairola C
Pyrrolo (1,4) benzodiazepine antitumor antibiotics: Biosynthetic studies on the conversion of tryptophan to the anthranilic acid moieties of sibiromycin and tomaymycin.
Antimicrobial agents and chemotherapy 1979;15(1):42-5.
1978: Hannan M A; Hurley L H
Pathways of DNA repair operating in yeast treated with the pyrrolo(1,4)-benzodiazepine antitumor antibiotics.
The Journal of antibiotics 1978;31(9):911-3.
1978: Hannan M A; Hurley L H; Gairola C
Mutagenic and recombinogenic effects of the antitumor antibiotic anthramycin.
Cancer research 1978;38(9):2795-9.
1977: Hurley L H
Pyrrolo(1,4)benzodiazepine antitumor antibiotics. Comparative aspects of anthramycin, tomaymycin and sibiromycin.
The Journal of antibiotics 1977;30(5):349-70.
1977: Hurley L H; Gairola C; Zmijewski M
Pyrrolo(1,4)benzodiazepine antitumor antibiotics. In vitro interaction of anthramycin, sibiromycin and tomaymycin with DNA using specifically radiolabelled molecules.
Biochimica et biophysica acta 1977;475(3):521-35.
1976: Hurley L H; Gairola C; Das N V
Pyrrolo[1,4]benzodiazepine antibiotics. Biosynthesis of the antitumor antibiotic 11-demethyltomaymycin and its biologically inactive metabolite oxotomaymycin by Streptomyces achromogenes.
Biochemistry 1976;15(17):3760-9.
1976: Chang C J; Floss H G; Hurley L H; Zmijewski M
Application of long-range spin-spin couplings in biosynthetic studies.
The Journal of organic chemistry 1976;41(17):2932-4.
1975: Hurley L H; Zmijewski M; Chang C J
Biosynthesis of anthramycin. Determination of the labeling pattern by the use of radioactive and stable isotope techniques.
Journal of the American Chemical Society 1975;97(15):4372-8.
1974: Hurley L H; Bialek D
Regulation of antibiotic production: catabolite inhibition and the dualistic effect of glucose on indolmycin production.
The Journal of antibiotics 1974;27(1):49-56.
1971: Hornemann U; Hurley L H; Speedie M K; Floss H G
The biosynthesis of indolmycin.
Journal of the American Chemical Society 1971;93(12):3028-35.
1970: Hornemann U; Hurley L H; Speedie M K; Floss H G
Isolation and absolute configuration of indolmycenic acid, an intermediate in the biosynthesis of indolmycin by Streptomyces griseus.
Tetrahedron letters 1970;26():2255-8.
1970: Hornemann U; Speedie M K; Hurley L H; Floss H G
Demonstration of a C-methylating enzyme in cell free extracts of indolmycin-producing Streptomyces griseus.
Biochemical and biophysical research communications 1970;39(4):594-9.
1969: Hornemann U; Speedie M K; Kelley K M; Hurley L H; Floss H G
Biosynthesis of indoleisopropionic acid by Claviceps. Biological C-methylation involving an intact methyl group.
Archives of biochemistry and biophysics 1969;131(2):430-40.

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