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Laurence Hurley

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Adam Siddiqui-Jain; Laurence H Hurley
DNA structure: Visualizing the quadruplex.
Christine E Kaiser; Danzhou Yang; Vijay Gokhale; Laurence H Hurley
Gaining Insights into the Small Molecule Targeting of the G-Quadruplex in the c-MYC Promoter Using NMR and an Allele-Specific Transcriptional Assay.
Yuwei Chen; Emmanuel Hatzakis; Laurence H Hurley; Prashansa Agrawal; Robert V Brown; Danzhou Yang
The major G-quadruplex formed in the human platelet-derived growth factor receptor β promoter adopts a novel broken-strand structure in K+ solution.

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All Publications

2013: Adam Siddiqui-Jain; Laurence H Hurley
DNA structure: Visualizing the quadruplex.
Nature chemistry 2013;5(3):153-5.
2013: Christine E Kaiser; Danzhou Yang; Vijay Gokhale; Laurence H Hurley
Gaining Insights into the Small Molecule Targeting of the G-Quadruplex in the c-MYC Promoter Using NMR and an Allele-Specific Transcriptional Assay.
Topics in current chemistry 2013;330():1-21.
2012: Yuwei Chen; Emmanuel Hatzakis; Laurence H Hurley; Prashansa Agrawal; Robert V Brown; Danzhou Yang
The major G-quadruplex formed in the human platelet-derived growth factor receptor β promoter adopts a novel broken-strand structure in K+ solution.
Journal of the American Chemical Society 2012;134(32):13220-3.
2012: Peda V L Boddupally; Tracy A Brooks; Biswanath De; Vijay Gokhale; Seongmin Hahn; Cristina Beman; Laurence H Hurley
Anticancer activity and cellular repression of c-MYC by the G-quadruplex-stabilizing 11-piperazinylquindoline is not dependent on direct targeting of the G-quadruplex in the c-MYC promoter.
Journal of medicinal chemistry 2012;55(13):6076-86.
2012: Zhongbo Yu; Yuan Zhao; Yunxi Cui; Vanessa Gaerig; Vijay Gokhale; Laurence H Hurley; HyunJin Kang; Hanbin Mao
Tertiary DNA structure in the single-stranded hTERT promoter fragment unfolds and refolds by parallel pathways via cooperative or sequential events.
Journal of the American Chemical Society 2012;134(11):5157-64.
2011: Jixun Dai; Laurence H Hurley; Megan Carver; Danzhou Yang
Solution structure of a 2:1 quindoline-c-MYC G-quadruplex: insights into G-quadruplex-interactive small molecule drug design.
Journal of the American Chemical Society 2011;133(44):17673-80.
2011: Shankar Balasubramanian; Laurence H Hurley; Stephen Neidle
Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?
Nature reviews. Drug discovery 2011;10(4):261-75.
2011: Robert V Brown; Laurence H Hurley
DNA acting like RNA.
Biochemical Society transactions 2011;39(2):635-40.
2010: Verónica González; Laurence H Hurley
The C-terminus of nucleolin promotes the formation of the c-MYC G-quadruplex and inhibits c-MYC promoter activity.
Biochemistry 2010;49(45):9706-14.
2010: Tracy A Brooks; Samantha Kendrick; Laurence H Hurley
Making sense of G-quadruplex and i-motif functions in oncogene promoters.
The FEBS journal 2010;277(17):3459-69.
2010: Justin Dietrich; Christopher Hulme; Laurence H Hurley
The design, synthesis, and evaluation of 8 hybrid DFG-out allosteric kinase inhibitors: a structural analysis of the binding interactions of Gleevec, Nexavar, and BIRB-796.
Bioorganic & medicinal chemistry 2010;18(15):5738-48.
2010: Yong Qin; Jessica S Fortin; Denise Tye; Mary Gleason-Guzman; Tracy A Brooks; Laurence H Hurley
Molecular cloning of the human platelet-derived growth factor receptor beta (PDGFR-beta) promoter and drug targeting of the G-quadruplex-forming region to repress PDGFR-beta expression.
Biochemistry 2010;49(19):4208-19.
2010: Jixun Dai; Emmanuel Hatzakis; Laurence H Hurley; Danzhou Yang
I-motif structures formed in the human c-MYC promoter are highly dynamic--insights into sequence redundancy and I-motif stability.
PloS one 2010;5(7):e11647.
2010: Daekyu Sun; Laurence H Hurley
Biochemical techniques for the characterization of G-quadruplex structures: EMSA, DMS footprinting, and DNA polymerase stop assay.
Methods in molecular biology (Clifton, N.J.) 2010;608():65-79.
2010: Justin Dietrich; Vijay Gokhale; Xiadong Wang; Laurence H Hurley; Gary A Flynn
Application of a novel [3+2] cycloaddition reaction to prepare substituted imidazoles and their use in the design of potent DFG-out allosteric B-Raf inhibitors.
Bioorganic & medicinal chemistry 2010;18(1):292-304.
2010: Verónica González; Laurence H Hurley
The c-MYC NHE III(1): function and regulation.
Annual review of pharmacology and toxicology 2010;50():111-29.
2010: Nicole E Hurley; Lisa A Schildmeyer; Kami A Bosworth; Yumiko Sakurai; Suzanne G Eskin; Laurence H Hurley; Larry V McIntire
Modulating the functional contributions of c-Myc to the human endothelial cell cyclic strain response.
Journal of vascular research 2010;47(1):80-90.
2009: Samantha Kendrick; Yoshitsugu Akiyama; Sidney Hecht; Laurence H Hurley
The i-motif in the bcl-2 P1 promoter forms an unexpectedly stable structure with a unique 8:5:7 loop folding pattern.
Journal of the American Chemical Society 2009;131(48):17667-76.
2009: Tracy A Brooks; Laurence H Hurley
The role of supercoiling in transcriptional control of MYC and its importance in molecular therapeutics.
Nature reviews. Cancer 2009;9(12):849-61.
2009: Arthur Y Shaw; Meredith C Henderson; Gary Flynn; Betty Samulitis; Haiyong Han; Steve P Stratton; H-H Sherry Chow; Laurence H Hurley; Robert T Dorr
Characterization of novel diaryl oxazole-based compounds as potential agents to treat pancreatic cancer.
The Journal of pharmacology and experimental therapeutics 2009;331(2):636-47.
2009: Verónica González; Kexiao Guo; Laurence H Hurley; Daekyu Sun
Identification and characterization of nucleolin as a c-myc G-quadruplex-binding protein.
The Journal of biological chemistry 2009;284(35):23622-35.
2009: SunMi L Palumbo; Scot W Ebbinghaus; Laurence H Hurley
Formation of a unique end-to-end stacked pair of G-quadruplexes in the hTERT core promoter with implications for inhibition of telomerase by G-quadruplex-interactive ligands.
Journal of the American Chemical Society 2009;131(31):10878-91.
2009: Tobias Hahn; Karen Fried; Laurence H Hurley; Emmanuel T Akporiaye
Orally active alpha-tocopheryloxyacetic acid suppresses tumor growth and multiplicity of spontaneous murine breast cancer.
Molecular cancer therapeutics 2009;8(6):1570-8.
2009: Daekyu Sun; Laurence H Hurley
The importance of negative superhelicity in inducing the formation of G-quadruplex and i-motif structures in the c-Myc promoter: implications for drug targeting and control of gene expression.
Journal of medicinal chemistry 2009;52(9):2863-74.
2009: Jixun Dai; Attila Ambrus; Laurence H Hurley; Danzhou Yang
A direct and nondestructive approach to determine the folding structure of the I-motif DNA secondary structure by NMR.
Journal of the American Chemical Society 2009;131(17):6102-4.
2009: Thomas S Dexheimer; Steven S Carey; Song Zuohe; Vijay Gokhale; Xiaohui Hu; Lauren B Murata; Estelle M Maes; Andrzej Weichsel; Daekyu Sun; Emmanuelle J Meuillet; William R Montfort; Laurence H Hurley
NM23-H2 may play an indirect role in transcriptional activation of c-myc gene expression but does not cleave the nuclease hypersensitive element III(1).
Molecular cancer therapeutics 2009;8(5):1363-77.
2009: Meredith Henderson; Yeng-Jeng Y Shaw; Hong Wang; Haiyong Han; Laurence H Hurley; Gary Flynn; Robert T Dorr; Daniel Von Hoff
UA62784, a novel inhibitor of centromere protein E kinesin-like protein.
Molecular cancer therapeutics 2009;8(1):36-44.
2008: Steven S Carey; Mary Gleason-Guzman; Vijay Gokhale; Laurence H Hurley
Psorospermin structural requirements for P-glycoprotein resistance reversal.
Molecular cancer therapeutics 2008;7(11):3617-23.
2008: Kexiao Guo; Vijay Gokhale; Laurence H Hurley; Daekyu Sun
Intramolecularly folded G-quadruplex and i-motif structures in the proximal promoter of the vascular endothelial growth factor gene.
Nucleic acids research 2008;36(14):4598-608.
2008: Yong Qin; Laurence H Hurley
Structures, folding patterns, and functions of intramolecular DNA G-quadruplexes found in eukaryotic promoter regions.
Biochimie 2008;90(8):1149-71.
2008: Daekyu Sun; Wei-Jun Liu; Kexiao Guo; Jadrian J Rusche; Scot W Ebbinghaus; Vijay Gokhale; Laurence H Hurley
The proximal promoter region of the human vascular endothelial growth factor gene has a G-quadruplex structure that can be targeted by G-quadruplex-interactive agents.
Molecular cancer therapeutics 2008;7(4):880-9.
2008: SunMi L Palumbo; Regan M Memmott; Diana J Uribe; Yulia Krotova-Khan; Laurence H Hurley; Scot W Ebbinghaus
A novel G-quadruplex-forming GGA repeat region in the c-myb promoter is a critical regulator of promoter activity.
Nucleic acids research 2008;36(6):1755-69.
2008: Derek J Cashman; Robert Buscaglia; Matthew W Freyer; Jamie Dettler; Laurence H Hurley; Edwin Lewis
Molecular modeling and biophysical analysis of the c-MYC NHE-III1 silencer element.
Journal of molecular modeling 2008;14(2):93-101.
2007: Kexiao Guo; Alan Pourpak; Kara Beetz-Rogers; Vijay Gokhale; Daekyu Sun; Laurence H Hurley
Formation of pseudosymmetrical G-quadruplex and i-motif structures in the proximal promoter region of the RET oncogene.
Journal of the American Chemical Society 2007;129(33):10220-8.
2007: Ming Zhu; Vijay Gokhale; Lajos Szabo; Ruben M Munoz; Hyounggee Baek; Sridevi Bashyam; Laurence H Hurley; Daniel Von Hoff; Haiyong Han
Identification of a novel inhibitor of urokinase-type plasminogen activator.
Molecular cancer therapeutics 2007;6(4):1348-56.
2007: Matthew W Freyer; Robert Buscaglia; Kimberly Kaplan; Derek J Cashman; Laurence H Hurley; Edwin Lewis
Biophysical studies of the c-MYC NHE III1 promoter: model quadruplex interactions with a cationic porphyrin.
Biophysical journal 2007;92(6):2007-15.
2007: Yong Qin; Evonne M Rezler; Vijay Gokhale; Daekyu Sun; Laurence H Hurley
Characterization of the G-quadruplexes in the duplex nuclease hypersensitive element of the PDGF-A promoter and modulation of PDGF-A promoter activity by TMPyP4.
Nucleic acids research 2007;35(22):7698-713.
2006: Steven L Warner; Ruben M Munoz; Phillip Stafford; Erich Koller; Laurence H Hurley; Daniel Von Hoff; Haiyong Han
Comparing Aurora A and Aurora B as molecular targets for growth inhibition of pancreatic cancer cells.
Molecular cancer therapeutics 2006;5(10):2450-8.
2006: Tobias Hahn; Lajos Szabo; Mikhal Gold; Lalitha V Ramanathapuram; Laurence H Hurley; Emmanuel T Akporiaye
Dietary administration of the proapoptotic vitamin E analogue alpha-tocopheryloxyacetic acid inhibits metastatic murine breast cancer.
Cancer research 2006;66(19):9374-8.
2006: Laurence H Hurley; Daniel Von Hoff; Adam Siddiqui-Jain; Danzhou Yang
Drug targeting of the c-MYC promoter to repress gene expression via a G-quadruplex silencer element.
Seminars in oncology 2006;33(4):498-512.
2006: Steven L Warner; Sridevi Bashyam; Hariprasad Vankayalapati; David J Bearss; Haiyong Han; Daruka Mahadevan; Daniel Von Hoff; Laurence H Hurley
Identification of a lead small-molecule inhibitor of the Aurora kinases using a structure-assisted, fragment-based approach.
Molecular cancer therapeutics 2006;5(7):1764-73.
2006: Thomas S Dexheimer; Daekyu Sun; Laurence H Hurley
Deconvoluting the structural and drug-recognition complexity of the G-quadruplex-forming region upstream of the bcl-2 P1 promoter.
Journal of the American Chemical Society 2006;128(16):5404-15.
2006: Jixun Dai; Ding Chen; Roger A Jones; Laurence H Hurley; Danzhou Yang
NMR solution structure of the major G-quadruplex structure formed in the human BCL2 promoter region.
Nucleic acids research 2006;34(18):5133-44.
2006: Danzhou Yang; Laurence H Hurley
Structure of the biologically relevant G-quadruplex in the c-MYC promoter.
Nucleosides, nucleotides & nucleic acids 2006;25(8):951-68.
2005: Richard De Armond; Stacey Wood; Daekyu Sun; Laurence H Hurley; Scot W Ebbinghaus
Evidence for the presence of a guanine quadruplex forming region within a polypurine tract of the hypoxia inducible factor 1alpha promoter.
Biochemistry 2005;44(49):16341-50.
2005: Eugene W Gerner; Natalia A Ignatenko; Peter Lance; Laurence H Hurley
A comprehensive strategy to combat colon cancer targeting the adenomatous polyposis coli tumor suppressor gene.
Annals of the New York Academy of Sciences 2005;1059():97-105.
2005: Ingrid M Fellows; Michael Schwaebe; Thomas S Dexheimer; Hariprasad Vankayalapati; Mary Gleason-Guzman; Jeffrey P Whitten; Laurence H Hurley
Determination of the importance of the stereochemistry of psorospermin in topoisomerase II-induced alkylation of DNA and in vitro and in vivo biological activity.
Molecular cancer therapeutics 2005;4(11):1729-39.
2005: Evonne M Rezler; Jeyaprakashnarayanan Seenisamy; Sridevi Bashyam; Mu-Yong Kim; Elizabeth White; David W. Wilson; Laurence H Hurley
Telomestatin and diseleno sapphyrin bind selectively to two different forms of the human telomeric G-quadruplex structure.
Journal of the American Chemical Society 2005;127(26):9439-47.
2005: Robert A Heald; Thomas S Dexheimer; Hariprasad Vankayalapati; Adam Siddiqui-Jain; Lajos Szabo; Mary Gleason-Guzman; Laurence H Hurley
Conformationally restricted analogues of psorospermin: design, synthesis, and bioactivity of natural-product-related bisfuranoxanthones.
Journal of medicinal chemistry 2005;48(8):2993-3004.
2005: Jeyaprakashnarayanan Seenisamy; Sridevi Bashyam; Vijay Gokhale; Hariprasad Vankayalapati; Daekyu Sun; Adam Siddiqui-Jain; Nicole Streiner; Kazuo Shin-Ya; Elizabeth White; David W. Wilson; Laurence H Hurley
Design and synthesis of an expanded porphyrin that has selectivity for the c-MYC G-quadruplex structure.
Journal of the American Chemical Society 2005;127(9):2944-59.
2005: Cory L Grand; Tiffanie J Powell; Raymond B Nagle; David J Bearss; Denise Tye; Mary Gleason-Guzman; Laurence H Hurley
Mutations in the G-quadruplex silencer element and their relationship to c-MYC overexpression, NM23 repression, and therapeutic rescue.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(2):516.
2005: Weijun Liu; Daekyu Sun; Laurence H Hurley
Binding of G-quadruplex-interactive agents to distinct G-quadruplexes induces different biological effects in MiaPaCa cells.
Nucleosides, nucleotides & nucleic acids 2005;24(10-12):1801-15.
2005: Daekyu Sun; Kexiao Guo; Jadrian J Rusche; Laurence H Hurley
Facilitation of a structural transition in the polypurine/polypyrimidine tract within the proximal promoter region of the human VEGF gene by the presence of potassium and G-quadruplex-interactive agents.
Nucleic acids research 2005;33(18):6070-80.
2004: Zhanna V Zhilina; Amy J Ziemba; John O Trent; Michael W Reed; Vladimir V Gorn; Qun Zhou; Wenhu Duan; Laurence H Hurley; Scot W Ebbinghaus
Synthesis and evaluation of a triplex-forming oligonucleotide-pyrrolobenzodiazepine conjugate.
Bioconjugate chemistry 2004;15(6):1182-92.
2004: Anil K Mehta; Yuda Shayo; Hariprasad Vankayalapati; Laurence H Hurley; Jacob Schaefer
Structure of a quinobenzoxazine--G-quadruplex complex by REDOR NMR.
Biochemistry 2004;43(38):11953-8.
2004: Jeyaprakashnarayanan Seenisamy; Evonne M Rezler; Tiffanie J Powell; Denise Tye; Vijay Gokhale; Chandana Sharma Joshi; Adam Siddiqui-Jain; Laurence H Hurley
The dynamic character of the G-quadruplex element in the c-MYC promoter and modification by TMPyP4.
Journal of the American Chemical Society 2004;126(28):8702-9.
2004: Cory L Grand; Tiffanie J Powell; Raymond B Nagle; David J Bearss; Denise Tye; Mary Gleason-Guzman; Laurence H Hurley
Mutations in the G-quadruplex silencer element and their relationship to c-MYC overexpression, NM23 repression, and therapeutic rescue.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(16):6140-5.
2004: Masood Ahmad Shammas; Robert J Shmookler Reis; Cheng Li; Hemanta Koley; Laurence H Hurley; Kenneth C Anderson; Nikhil C Munshi
Telomerase inhibition and cell growth arrest after telomestatin treatment in multiple myeloma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(2):770-6.
2003: Masood Ahmad Shammas; Robert J Shmookler Reis; Masaharu Akiyama; Hemanta Koley; Dharminder Chauhan; Teru Hideshima; Raj K Goyal; Laurence H Hurley; Kenneth C Anderson; Nikhil C Munshi
Telomerase inhibition and cell growth arrest by G-quadruplex interactive agent in multiple myeloma.
Molecular cancer therapeutics 2003;2(9):825-33.
2003: Pnina Weisman-Shomer; Esther Cohen; Inbal Hershco; Samer Khateb; Orit Wolfovitz-Barchad; Laurence H Hurley; Michael Fry
The cationic porphyrin TMPyP4 destabilizes the tetraplex form of the fragile X syndrome expanded sequence d(CGG)n.
Nucleic acids research 2003;31(14):3963-70.
2003: Mu-Yong Kim; Younghwa Na; Hariprasad Vankayalapati; Mary Gleason-Guzman; Laurence H Hurley
Design, synthesis, and evaluation of psorospermin/quinobenzoxazine hybrids as structurally novel antitumor agents.
Journal of medicinal chemistry 2003;46(14):2958-72.
2003: Mu-Yong Kim; Mary Gleason-Guzman; Elzbieta Izbicka; David Nishioka; Laurence H Hurley
The different biological effects of telomestatin and TMPyP4 can be attributed to their selectivity for interaction with intramolecular or intermolecular G-quadruplex structures.
Cancer research 2003;63(12):3247-56.
2003: Mu-Yong Kim; Wenhu Duan; Mary Gleason-Guzman; Laurence H Hurley
Design, synthesis, and biological evaluation of a series of fluoroquinoanthroxazines with contrasting dual mechanisms of action against topoisomerase II and G-quadruplexes.
Journal of medicinal chemistry 2003;46(4):571-83.
2003: Evonne M Rezler; David J Bearss; Laurence H Hurley
Telomere inhibition and telomere disruption as processes for drug targeting.
Annual review of pharmacology and toxicology 2003;43():359-79.
2002: Adam Siddiqui-Jain; Cory L Grand; David J Bearss; Laurence H Hurley
Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-MYC transcription.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(18):11593-8.
2002: Evonne M Rezler; David J Bearss; Laurence H Hurley
Telomeres and telomerases as drug targets.
Current opinion in pharmacology 2002;2(4):415-23.
2002: Cory L Grand; Haiyong Han; Rubén M Muñoz; Steven D Weitman; Daniel Von Hoff; Laurence H Hurley; David J Bearss
The cationic porphyrin TMPyP4 down-regulates c-MYC and human telomerase reverse transcriptase expression and inhibits tumor growth in vivo.
Molecular cancer therapeutics 2002;1(8):565-73.
2002: Mu-Yong Kim; Hariprasad Vankayalapati; Kazuo Shin-Ya; Konstanty Wierzba; Laurence H Hurley
Telomestatin, a potent telomerase inhibitor that interacts quite specifically with the human telomeric intramolecular g-quadruplex.
Journal of the American Chemical Society 2002;124(10):2098-9.
2002: Laurence H Hurley
DNA and its associated processes as targets for cancer therapy.
Nature reviews. Cancer 2002;2(3):188-200.
2002: Maryanne C S Herzig; Karl A Rodriguez; Alex V Trevino; Jaroslaw Dziegielewski; Brenda Arnett; Laurence H Hurley; Jan Woynarowski
The genome factor in region-specific DNA damage: the DNA-reactive drug U-78779 prefers mixed A/T-G/C sequences at the nucleotide level but is region-specific for long pure AT islands at the genomic level.
Biochemistry 2002;41(5):1545-55.
2001: D F Shi; RT Wheelhouse; Daekyu Sun; Laurence H Hurley
Quadruplex-interactive agents as telomerase inhibitors: synthesis of porphyrins and structure-activity relationship for the inhibition of telomerase.
Journal of medicinal chemistry 2001;44(26):4509-23.
2001: W Duan; Anupama Rangan; Hariprasad Vankayalapati; Mu-Yong Kim; Q Zeng; Daekyu Sun; Haiyong Han; OY Fedoroff; David Nishioka; S Y Rha; Elzbieta Izbicka; Daniel Von Hoff; Laurence H Hurley
Design and synthesis of fluoroquinophenoxazines that interact with human telomeric G-quadruplexes and their biological effects.
Molecular cancer therapeutics 2001;1(2):103-20.
2001: M Zewail-Foote; V S Li; Harold Kohn; David J Bearss; M Guzman; Laurence H Hurley
The inefficiency of incisions of ecteinascidin 743-DNA adducts by the UvrABC nuclease and the unique structural feature of the DNA adducts can be used to explain the repair-dependent toxicities of this antitumor agent.
Chemistry & biology 2001;8(11):1033-49.
2001: Laurence H Hurley
Secondary DNA structures as molecular targets for cancer therapeutics.
Biochemical Society transactions 2001;29(Pt 6):692-6.
2001: Haiyong Han; D R Langley; Anupama Rangan; Laurence H Hurley
Selective interactions of cationic porphyrins with G-quadruplex structures.
Journal of the American Chemical Society 2001;123(37):8902-13.
2001: M Zewail-Foote; Laurence H Hurley
Differential rates of reversibility of ecteinascidin 743-DNA covalent adducts from different sequences lead to migration to favored bonding sites.
Journal of the American Chemical Society 2001;123(27):6485-95.
2001: Q Zhou; W Duan; D Simmons; Y Shayo; Mary Ann Raymond; Robert T Dorr; Laurence H Hurley
Design and synthesis of a novel DNA-DNA interstrand adenine-guanine cross-linking agent.
Journal of the American Chemical Society 2001;123(20):4865-6.
2001: Anupama Rangan; OY Fedoroff; Laurence H Hurley
Induction of duplex to G-quadruplex transition in the c-myc promoter region by a small molecule.
The Journal of biological chemistry 2001;276(7):4640-6.
2001: Laurence H Hurley; M Zewail-Foote
The antitumor agent ecteinascidin 743: characterization of its covalent DNA adducts and chemical stability.
Advances in experimental medicine and biology 2001;500():289-99.
2001: D Sun; Laurence H Hurley
Targeting telomeres and telomerase.
Methods in enzymology 2001;340():573-92.
2000: David J Bearss; Laurence H Hurley; Daniel Von Hoff
Telomere maintenance mechanisms as a target for drug development.
Oncogene 2000;19(56):6632-41.
2000: OY Fedoroff; Anupama Rangan; Violetta Chemeris; Laurence H Hurley
Cationic porphyrins promote the formation of i-motif DNA and bind peripherally by a nonintercalative mechanism.
Biochemistry 2000;39(49):15083-90.
2000: Hongtao Yu; Y Kwok; Laurence H Hurley; Sean M Kerwin
Efficient, Mg(2+)-dependent photochemical DNA cleavage by the antitumor quinobenzoxazine (S)-A-62176.
Biochemistry 2000;39(33):10236-46.
2000: Haiyong Han; R J Bennett; Laurence H Hurley
Inhibition of unwinding of G-quadruplex structures by Sgs1 helicase in the presence of N,N'-bis[2-(1-piperidino)ethyl]-3,4,9,10-perylenetetracarboxylic diimide, a G-quadruplex-interactive ligand.
Biochemistry 2000;39(31):9311-6.
2000: Eric Raymond; J C Soria; Elzbieta Izbicka; F Boussin; Laurence H Hurley; Daniel Von Hoff
DNA G-quadruplexes, telomere-specific proteins and telomere-associated enzymes as potential targets for new anticancer drugs.
Investigational new drugs 2000;18(2):123-37.
2000: Haiyong Han; Laurence H Hurley
G-quadruplex DNA: a potential target for anti-cancer drug design.
Trends in pharmacological sciences 2000;21(4):136-42.
2000: S Y Rha; Elzbieta Izbicka; R Lawrence; K Davidson; D Sun; Mary Pat Moyer; David G Roodman; Laurence H Hurley; Daniel Von Hoff
Effect of telomere and telomerase interactive agents on human tumor and normal cell lines.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(3):987-93.
2000: Laurence H Hurley; RT Wheelhouse; Daekyu Sun; Sean M Kerwin; Miguel Salazar; OY Fedoroff; F X Han; Haiyong Han; Elzbieta Izbicka; Daniel Von Hoff
G-quadruplexes as targets for drug design.
Pharmacology & therapeutics 2000;85(3):141-58.
1999: Y Kwok; Daekyu Sun; J J Clement; Laurence H Hurley
The quinobenzoxazines: relationship between DNA binding and biological activity.
Anti-cancer drug design 1999;14(5):443-50.
1999: BE Cathers; Daekyu Sun; Laurence H Hurley
Accurate determination of quadruplex binding affinity and potency of G-quadruplex-interactive telomerase inhibitors by use of a telomerase extension assay requires varying the primer concentration.
Anti-cancer drug design 1999;14(4):367-72.
1999: Elzbieta Izbicka; David Nishioka; V Marcell; E Raymond; KK Davidson; RA Lawrence; RT Wheelhouse; Laurence H Hurley; R S Wu; Daniel Von Hoff
Telomere-interactive agents affect proliferation rates and induce chromosomal destabilization in sea urchin embryos.
Anti-cancer drug design 1999;14(4):355-65.
1999: M Zewail-Foote; Laurence H Hurley
Ecteinascidin 743: a minor groove alkylator that bends DNA toward the major groove.
Journal of medicinal chemistry 1999;42(14):2493-7.
1999: Y Kwok; Q Zeng; Laurence H Hurley
Structural insight into a quinolone-topoisomerase II-DNA complex. Further evidence for a 2:2 quinobenzoxazine-mg2+ self-assembly model formed in the presence of topoisomerase ii.
The Journal of biological chemistry 1999;274(24):17226-35.
1999: Haiyong Han; C L Cliff; Laurence H Hurley
Accelerated assembly of G-quadruplex structures by a small molecule.
Biochemistry 1999;38(22):6981-6.
1999: Daekyu Sun; C C Lopez-Guajardo; J Quada; Laurence H Hurley; Daniel Von Hoff
Regulation of catalytic activity and processivity of human telomerase.
Biochemistry 1999;38(13):4037-44.
1999: M Zewail-Foote; Laurence H Hurley
Molecular approaches to achieving control of gene expression by drug intervention at the transcriptional level.
Anti-cancer drug design 1999;14(1):1-9.
1999: Elzbieta Izbicka; RT Wheelhouse; E Raymond; KK Davidson; RA Lawrence; Daekyu Sun; BE Windle; Laurence H Hurley; Daniel Von Hoff
Effects of cationic porphyrins as G-quadruplex interactive agents in human tumor cells.
Cancer research 1999;59(3):639-44.
1999: Haiyong Han; Laurence H Hurley; Miguel Salazar
A DNA polymerase stop assay for G-quadruplex-interactive compounds.
Nucleic acids research 1999;27(2):537-42.
1998: Y Kwok; Laurence H Hurley
Topoisomerase II site-directed alkylation of DNA by psorospermin and its effect on topoisomerase II-mediated DNA cleavage.
The Journal of biological chemistry 1998;273(49):33020-6.
1998: D Sun; Laurence H Hurley; Daniel Von Hoff
Telomerase assay using biotinylated-primer extension and magnetic separation of the products.
BioTechniques 1998;25(6):1046-51.
1998: Y Kwok; Q Zeng; Laurence H Hurley
Topoisomerase II-mediated site-directed alkylation of DNA by psorospermin and its use in mapping other topoisomerase II poison binding sites.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(23):13531-6.
1998: Q Zeng; Y Kwok; Sean M Kerwin; G Mangold; Laurence H Hurley
Design of new topoisomerase II inhibitors based upon a quinobenzoxazine self-assembly model.
Journal of medicinal chemistry 1998;41(22):4273-8.
1998: OY Fedoroff; Miguel Salazar; Haiyong Han; Violetta Chemeris; Sean M Kerwin; Laurence H Hurley
NMR-Based model of a telomerase-inhibiting compound bound to G-quadruplex DNA.
Biochemistry 1998;37(36):12367-74.
1998: Terace M Fletcher; D Sun; M Salazar; Laurence H Hurley
Effect of DNA secondary structure on human telomerase activity.
Biochemistry 1998;37(16):5536-41.
1997: Daekyu Sun; B Thompson; BE Cathers; Miguel Salazar; S M Kerwin; J O Trent; T C Jenkins; S Neidle; Laurence H Hurley
Inhibition of human telomerase by a G-quadruplex-interactive compound.
Journal of medicinal chemistry 1997;40(14):2113-6.
1996: Miguel Salazar; B D Thompson; Sean M Kerwin; Laurence H Hurley
Thermally induced DNA.RNA hybrid to G-quadruplex transitions: possible implications for telomere synthesis by telomerase.
Biochemistry 1996;35(50):16110-5.
1996: Daekyu Sun; Laurence H Hurley; Rasika M Harshey
Structural distortions induced by integration host factor (IHF) at the H' site of phage lambda probed by (+)-CC-1065, pluramycin, and KMnO4 and by DNA cyclization studies.
Biochemistry 1996;35(33):10815-27.
1996: F X Han; Laurence H Hurley
A model for the T-antigen-induced structural alteration of the SV40 replication origin based upon experiments with specific probes for bent, straight, and unwound DNA.
Biochemistry 1996;35(24):7993-8001.
1996: Douglas P Henderson; Laurence H Hurley
Specific targeting of protein-DNA complexes by DNA-reactive drugs (+)-CC-1065 and pluramycins.
Journal of molecular recognition : JMR 1996;9(2):75-87.
1995: A S Thompson; Laurence H Hurley
Solution conformation of a bizelesin A-tract duplex adduct: DNA-DNA cross-linking of an A-tract straightens out bent DNA.
Journal of molecular biology 1995;252(1):86-101.
1995: A S Thompson; J Y Fan; Daekyu Sun; M Hansen; Laurence H Hurley
Determination of the structural role of the internal guanine-cytosine base pair in recognition of a seven-base-pair sequence cross-linked by bizelesin.
Biochemistry 1995;34(35):11005-16.
1995: Daekyu Sun; Laurence H Hurley
TBP binding to the TATA box induces a specific downstream unwinding site that is targeted by pluramycin.
Chemistry & biology 1995;2(7):457-69.
1995: Douglas P Henderson; Laurence H Hurley
Molecular struggle for transcriptional control.
Nature medicine 1995;1(6):525-7.
1995: M Hansen; S Yun; Laurence H Hurley
Hedamycin intercalates the DNA helix and, through carbohydrate-mediated recognition in the minor groove, directs N7-alkylation of guanine in the major groove in a sequence-specific manner.
Chemistry & biology 1995;2(4):229-40.
1995: J Y Fan; Daekyu Sun; Hongtao Yu; Sean M Kerwin; Laurence H Hurley
Self-assembly of a quinobenzoxazine-Mg2+ complex on DNA: a new paradigm for the structure of a drug-DNA complex and implications for the structure of the quinolone bacterial gyrase-DNA complex.
Journal of medicinal chemistry 1995;38(3):408-24.
1994: TC Jenkins; Laurence H Hurley; Stephen Neidle; D E Thurston
Structure of a covalent DNA minor groove adduct with a pyrrolobenzodiazepine dimer: evidence for sequence-specific interstrand cross-linking.
Journal of medicinal chemistry 1994;37(26):4529-37.
1994: Daekyu Sun; Laurence H Hurley
Binding of Sp1 to the 21-bp repeat region of SV40 DNA: effect of intrinsic and drug-induced DNA bending between GC boxes.
Gene 1994;149(1):165-72.
1994: J A Mountzouris; J J Wang; D Thurston; Laurence H Hurley
Comparison of a DSB-120 DNA interstrand cross-linked adduct with the corresponding bis-tomaymycin adduct: an example of a successful template-directed approach to drug design based upon the monoalkylating compound tomaymycin.
Journal of medicinal chemistry 1994;37(19):3132-40.
1994: Daekyu Sun; Laurence H Hurley
Cooperative bending of the 21-base-pair repeats of the SV40 viral early promoter by human Sp1.
Biochemistry 1994;33(32):9578-87.
1994: Laurence H Hurley; Daekyu Sun
(+)-CC-1065 as a probe for intrinsic and protein-induced bending of DNA.
Journal of molecular recognition : JMR 1994;7(2):123-32.
1994: Laurence H Hurley
The minor groove covalent reactive drugs anthramycin and (+)-CC-1065 and their interstrand cross-linking derivatives.
IARC scientific publications 1994;(125):295-312.
1993: F C Seaman; Laurence H Hurley
Interstrand cross-linking by bizelesin produces a Watson-Crick to Hoogsteen base-pairing transition region in d(CGTAATTACG)2.
Biochemistry 1993;32(47):12577-85.
1993: Daekyu Sun; H J Park; Laurence H Hurley
Alkylation of guanine and cytosine in DNA by bizelesin. Evidence for a covalent immobilization leading to a proximity-driven alkylation of normally unreactive bases by a (+)-CC-1065 cross-linking compound.
Chemical research in toxicology 1993;6(6):889-94.
1993: Z M Ding; Rasika M Harshey; Laurence H Hurley
(+)-CC-1065 as a structural probe of Mu transposase-induced bending of DNA: overcoming limitations of hydroxyl-radical footprinting.
Nucleic acids research 1993;21(18):4281-7.
1993: R Kizu; P H Draves; Laurence H Hurley
Correlation of DNA sequence specificity of anthramycin and tomaymycin with reaction kinetics and bending of DNA.
Biochemistry 1993;32(33):8712-22.
1993: Daekyu Sun; M Hansen; J J Clement; Laurence H Hurley
Structure of the altromycin B (N7-guanine)-DNA adduct. A proposed prototypic DNA adduct structure for the pluramycin antitumor antibiotics.
Biochemistry 1993;32(32):8068-74.
1993: Paul A Aristoff; P D Johnson; D Sun; Laurence H Hurley
Synthesis and biochemical evaluation of the CBI-PDE-I-dimer, a benzannelated analog of (+)-CC-1065 that also produces delayed toxicity in mice.
Journal of medicinal chemistry 1993;36(14):1956-63.
1993: Daekyu Sun; C H Lin; Laurence H Hurley
A-tract and (+)-CC-1065-induced bending of DNA. Comparison of structural features using non-denaturing gel analysis, hydroxyl-radical footprinting, and high-field NMR.
Biochemistry 1993;32(17):4487-95.
1992: J J Wang; G C Hill; Laurence H Hurley
Template-directed design of a DNA-DNA cross-linker based upon a bis-tomaymycin-duplex adduct.
Journal of medicinal chemistry 1992;35(16):2995-3002.
1992: Daekyu Sun; Laurence H Hurley
Structure-activity relationships of (+)-CC-1065 analogues in the inhibition of helicase-catalyzed unwinding of duplex DNA.
Journal of medicinal chemistry 1992;35(10):1773-82.
1992: I P Maine; D Sun; Laurence H Hurley; Thomas Kodadek
The antitumor agent CC-1065 inhibits helicase-catalyzed unwinding of duplex DNA.
Biochemistry 1992;31(16):3968-75.
1992: Daekyu Sun; Laurence H Hurley
Effect of the (+)-CC-1065-(N3-adenine)DNA adduct on in vitro DNA synthesis mediated by Escherichia coli DNA polymerase.
Biochemistry 1992;31(10):2822-9.
1992: C H Lin; G C Hill; Laurence H Hurley
Characterization of a 12-mer duplex d(GGCGGAGTTAGG).d(CCTAACTCCGCC) containing a highly reactive (+)-CC-1065 sequence by 1H and 31P NMR, hydroxyl-radical footprinting, and NOESY restrained molecular dynamics calculations.
Chemical research in toxicology 1992;5(2):167-82.
1992: Daekyu Sun; Laurence H Hurley
Inhibition of T4 DNA ligase activity by (+)-CC-1065: demonstration of the importance of the stiffening and winding effects of (+)-CC-1065 on DNA.
Anti-cancer drug design 1992;7(1):15-36.
1991: Z M Ding; Laurence H Hurley
DNA interstrand cross-linking, DNA sequence specificity, and induced conformational changes produced by a dimeric analog of (+)-CC-1065.
Anti-cancer drug design 1991;6(5):427-52.
1991: Moon-shong Tang; M E Nazimiec; R P Doisy; J R Pierce; Laurence H Hurley; B E Alderete
Repair of helix-stabilizing anthramycin-N2 guanine DNA adducts by UVRA and UVRB proteins.
Journal of molecular biology 1991;220(4):855-66.
1991: C H Lin; J M Beale; Laurence H Hurley
Structure of the (+)-CC-1065-DNA adduct: critical role of ordered water molecules and implications for involvement of phosphate catalysis in the covalent reaction.
Biochemistry 1991;30(15):3597-602.
1991: C S Lee; Daekyu Sun; R Kizu; Laurence H Hurley
Determination of the structural features of (+)-CC-1065 that are responsible for bending and winding of DNA.
Chemical research in toxicology 1991;4(2):203-13.
1991: C H Lin; D Y Sun; Laurence H Hurley
(+)-CC-1065 produces bending of DNA that appears to resemble adenine/thymine tracts.
Chemical research in toxicology 1991;4(1):21-6.
1990: C H Lin; Laurence H Hurley
Determination of the major tautomeric form of the covalently modified adenine in the (+)-CC-1065-DNA adduct by 1H and 15N NMR studies.
Biochemistry 1990;29(41):9503-7.
1990: F L Boyd; D Stewart; W A Remers; Mary D Barkley; Laurence H Hurley
Characterization of a unique tomaymycin-d(CICGAATTCICG)2 adduct containing two drug molecules per duplex by NMR, fluorescence, and molecular modeling studies.
Biochemistry 1990;29(9):2387-403.
1989: Laurence H Hurley
DNA and associated targets for drug design.
Journal of medicinal chemistry 1989;32(9):2027-33.
1988: Laurence H Hurley; F L Boyd
DNA as a target for drug action.
Trends in pharmacological sciences 1988;9(11):402-7.
1988: M A Warpehoski; Laurence H Hurley
Sequence selectivity of DNA covalent modification.
Chemical research in toxicology 1988;1(6):315-33.
1988: Laurence H Hurley; T Reck; D E Thurston; D R Langley; K G Holden; R P Hertzberg; J R Hoover; G Gallagher; L F Faucette; S M Mong
Pyrrolo[1,4]benzodiazepine antitumor antibiotics: relationship of DNA alkylation and sequence specificity to the biological activity of natural and synthetic compounds.
Chemical research in toxicology 1988;1(5):258-68.
1988: Laurence H Hurley; C S Lee; J P McGovren; M A Warpehoski; Mark Mitchell; R C Kelly; Paul A Aristoff
Molecular basis for sequence-specific DNA alkylation by CC-1065.
Biochemistry 1988;27(10):3886-92.
1988: Laurence H Hurley; C S Lee; J P McGovren; M A Warpehoski; M A Mitchell; R C Kelly; Paul A Aristoff
Reaction of CC-1065 and select synthetic analogs with DNA.
Biochemical pharmacology 1988;37(9):1795-6.
1988: S Cheatham; A Kook; Laurence H Hurley; M D Barkley; W Remers
One- and two-dimensional 1H NMR, fluorescence, and molecular modeling studies on the tomaymycin-d(ATGCAT)2 adduct. Evidence for two covalent adducts with opposite orientations and stereochemistries at the covalent linkage site.
Journal of medicinal chemistry 1988;31(3):583-90.
1988: Moon-shong Tang; C S Lee; R Doisy; L Ross; D R Needham-VanDevanter; Laurence H Hurley
Recognition and repair of the CC-1065-(N3-adenine)-DNA adduct by the UVRABC nucleases.
Biochemistry 1988;27(3):893-901.
1987: Laurence H Hurley
Molecular biology and medicinal chemistry.
Journal of medicinal chemistry 1987;30(10):7A-8A.
1987: Laurence H Hurley; D R Needham-VanDevanter; C S Lee
Demonstration of the asymmetric effect of CC-1065 on local DNA structure using a site-directed adduct in a 117-base-pair fragment from M13mp1.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(18):6412-6.
1986: D R Needham-VanDevanter; Laurence H Hurley
Construction and characterization of a site-directed CC-1065-N3-adenine adduct within a 117 base pair DNA restriction fragment.
Biochemistry 1986;25(26):8430-6.
1986: M K Jacobson; D Twehous; Laurence H Hurley
Depletion of nicotinamide adenine dinucleotide in normal and xeroderma pigmentosum fibroblast cells by the antitumor drug CC-1065.
Biochemistry 1986;25(20):5929-32.
1986: M D Barkley; S Cheatham; D E Thurston; Laurence H Hurley
Pyrrolo[1,4]benzodiazepine antitumor antibiotics: evidence for two forms of tomaymycin bound to DNA.
Biochemistry 1986;25(10):3021-31.
1986: R P Hertzberg; Sidney Hecht; V L Reynolds; I J Molineux; Laurence H Hurley
DNA sequence specificity of the pyrrolo[1,4]benzodiazepine antitumor antibiotics. Methidiumpropyl-EDTA-iron(II) footprinting analysis of DNA binding sites for anthramycin and related drugs.
Biochemistry 1986;25(6):1249-58.
1986: V L Reynolds; J P McGovren; Laurence H Hurley
The chemistry, mechanism of action and biological properties of CC-1065, a potent antitumor antibiotic.
The Journal of antibiotics 1986;39(3):319-34.
1986: Laurence H Hurley; D R Needham-VanDevanter
Sequence specificity and biological consequences of drugs that bind covalently in the minor groove of DNA.
Basic life sciences 1986;38():203-10.
1985: V L Reynolds; I J Molineux; D J Kaplan; D H Swenson; Laurence H Hurley
Reaction of the antitumor antibiotic CC-1065 with DNA. Location of the site of thermally induced strand breakage and analysis of DNA sequence specificity.
Biochemistry 1985;24(22):6228-37.
1984: Laurence H Hurley; V L Reynolds; D H Swenson; GL Petzold; T A Scahill
Reaction of the antitumor antibiotic CC-1065 with DNA: structure of a DNA adduct with DNA sequence specificity.
Science (New York, N.Y.) 1984;226(4676):843-4.
1984: D R Needham-VanDevanter; Laurence H Hurley; V L Reynolds; N Y Theriault; W C Krueger; W Wierenga
Characterization of an adduct between CC-1065 and a defined oligodeoxynucleotide duplex.
Nucleic acids research 1984;12(15):6159-68.
1984: David E Graves; C Pattaroni; B S Krishnan; J M Ostrander; Laurence H Hurley; T R Krugh
The reaction of anthramycin with DNA. Proton and carbon nuclear magnetic resonance studies on the structure of the anthramycin-DNA adduct.
The Journal of biological chemistry 1984;259(13):8202-9.
1983: Laurence H Hurley; Stefan Rokem
Biosynthesis of the antitumor antibiotic CC-1065 by Streptomyces zelensis.
The Journal of antibiotics 1983;36(4):383-90.
1982: V L Reynolds; Laurence H Hurley
Comparison of properties of the in vitro and cellular anthramycin-DNA adducts and characterization of the reaction of anthramycin with chromatin.
Chemico-biological interactions 1982;42(2):141-51.
1982: D H Swenson; L H Li; Laurence H Hurley; Stefan Rokem; GL Petzold; B D Dayton; T L Wallace; A H Lin; W C Krueger
Mechanism of interaction of CC-1065 (NSC 298223) with DNA.
Cancer research 1982;42(7):2821-8.
1982: R L Petrusek; E L Uhlenhopp; N Duteau; Laurence H Hurley
Reaction of anthramycin with DNA. Biological consequences of DNA damage in normal and xeroderma pigmentosum cell.
The Journal of biological chemistry 1982;257(11):6207-16.
1981: D J Kaplan; Laurence H Hurley
Anthramycin binding to deoxyribonucleic acid-mitomycin C complexes. Evidence for drug-induced deoxyribonucleic acid conformational change and cooperativity in mitomycin C binding.
Biochemistry 1981;20(26):7572-80.
1981: Stefan Rokem; Laurence H Hurley
Sensitivity and permeability of the anthramycin producing organism Streptomyces refuineus to anthramycin and structurally related antibiotics.
The Journal of antibiotics 1981;34(9):1171-4.
1981: R L Petrusek; G L Anderson; T F Garner; Q L Fannin; D J Kaplan; S G Zimmer; Laurence H Hurley
Pyrrol[1,4]benzodiazepine antibiotics. Proposed structures and characteristics of the in vitro deoxyribonucleic acid adducts of anthramycin, tomaymycin, sibiromycin, and neothramycins A and B.
Biochemistry 1981;20(5):1111-9.
1981: R K Malhotra; J M Ostrander; Laurence H Hurley; A G McInnes; D G Smith; John A Walter; Jeffrey L C Wright
Chemical conversion of anthramycin 11-methyl ether to didehydroanhydroanthramycin and its utilization in studies of the biosynthesis and mechanism of action of anthramycin.
Journal of natural products 1981;44(1):38-44.
1980: J M Ostrander; Laurence H Hurley; A G McInnes; D G Smith; John A Walter; Jeffrey L C Wright
Proof for the biosynthetic conversion of L-[indole-15N]tryptophan to [10-15N]anthramycin using (13C, 15N) labelling in conjunction with 13C-NMR and mass spectral analysis.
The Journal of antibiotics 1980;33(10):1167-71.
1980: Laurence H Hurley; Stefan Rokem; R L Petrusek
Proposed structures of the pyrrolo(1,4)benzodiazepine antibiotic-deoxyribonucleic acid adducts.
Biochemical pharmacology 1980;29(9):1307-10.
1980: M A Hannan; R S Estes; Laurence H Hurley
Induction and potentiation of lethal and genetic effects of ultraviolet light by tobacco smoke condensates in yeast.
Environmental research 1980;21(1):97-107.
1980: W C Lubawy; R A Dallam; Laurence H Hurley
Protection against anthramycin-induced toxicity in mice by coenzyme Q10.
Journal of the National Cancer Institute 1980;64(1):105-9.
1979: Laurence H Hurley; R Petrusek
Proposed structure of the anthramycin-DNA adduct.
Nature 1979;282(5738):529-31.
1979: Laurence H Hurley; W L Lasswell; J M Ostrander; R Parry
Pyrrolo[1,4]benzodiazepine antibiotics. Biosynthetic conversion of tyrosine to the C2- and C3-proline moieties of anthramycin, tomaymycin, and sibiromycin.
Biochemistry 1979;18(19):4230-7.
1979: Laurence H Hurley; W L Lasswell; R K Malhotra; N V Das
Pyrrolo[1,4]benzodiazepine antibiotics. Biosynthesis of the antitumor antibiotic sibiromycin by Streptosporangium sibiricum.
Biochemistry 1979;18(19):4225-9.
1979: Laurence H Hurley; C S Allen; J M Feola; W C Lubawy
In vitro and in vivo stability of anthramycin-DNA conjugate and its potential application as an anthramycin prodrug.
Cancer research 1979;39(8):3134-40.
1979: W C Lubawy; J Whaley; Laurence H Hurley
Coenzyme Q10 or alpha-tocopherol reduce the acute toxicity of anthramycin in mice.
Research communications in chemical pathology and pharmacology 1979;24(2):401-4.
1979: Laurence H Hurley; C Chandler; T F Garner; R Petrusek; S G Zimmer
DNA binding, induction of unscheduled DNA synthesis, and excision of anthramycin from DNA in normal and repair-deficient human fibroblasts.
The Journal of biological chemistry 1979;254(3):605-8.
1979: Laurence H Hurley; C Gairola
Pyrrolo (1,4) benzodiazepine antitumor antibiotics: Biosynthetic studies on the conversion of tryptophan to the anthranilic acid moieties of sibiromycin and tomaymycin.
Antimicrobial agents and chemotherapy 1979;15(1):42-5.
1978: M A Hannan; Laurence H Hurley
Pathways of DNA repair operating in yeast treated with the pyrrolo(1,4)-benzodiazepine antitumor antibiotics.
The Journal of antibiotics 1978;31(9):911-3.
1978: M A Hannan; Laurence H Hurley; C Gairola
Mutagenic and recombinogenic effects of the antitumor antibiotic anthramycin.
Cancer research 1978;38(9):2795-9.
1977: Laurence H Hurley
Pyrrolo(1,4)benzodiazepine antitumor antibiotics. Comparative aspects of anthramycin, tomaymycin and sibiromycin.
The Journal of antibiotics 1977;30(5):349-70.
1977: Laurence H Hurley; C Gairola; M Zmijewski
Pyrrolo(1,4)benzodiazepine antitumor antibiotics. In vitro interaction of anthramycin, sibiromycin and tomaymycin with DNA using specifically radiolabelled molecules.
Biochimica et biophysica acta 1977;475(3):521-35.
1976: Laurence H Hurley; C Gairola; N V Das
Pyrrolo[1,4]benzodiazepine antibiotics. Biosynthesis of the antitumor antibiotic 11-demethyltomaymycin and its biologically inactive metabolite oxotomaymycin by Streptomyces achromogenes.
Biochemistry 1976;15(17):3760-9.
1976: C J Chang; H G Floss; Laurence H Hurley; M Zmijewski
Application of long-range spin-spin couplings in biosynthetic studies.
The Journal of organic chemistry 1976;41(17):2932-4.
1975: Laurence H Hurley; M Zmijewski; C J Chang
Biosynthesis of anthramycin. Determination of the labeling pattern by the use of radioactive and stable isotope techniques.
Journal of the American Chemical Society 1975;97(15):4372-8.
1974: Laurence H Hurley; D Bialek
Regulation of antibiotic production: catabolite inhibition and the dualistic effect of glucose on indolmycin production.
The Journal of antibiotics 1974;27(1):49-56.
1971: U Hornemann; Laurence H Hurley; M K Speedie; H G Floss
The biosynthesis of indolmycin.
Journal of the American Chemical Society 1971;93(12):3028-35.
1970: U Hornemann; Laurence H Hurley; M K Speedie; H G Floss
Isolation and absolute configuration of indolmycenic acid, an intermediate in the biosynthesis of indolmycin by Streptomyces griseus.
Tetrahedron letters 1970;(26):2255-8.
1970: U Hornemann; M K Speedie; Laurence H Hurley; H G Floss
Demonstration of a C-methylating enzyme in cell free extracts of indolmycin-producing Streptomyces griseus.
Biochemical and biophysical research communications 1970;39(4):594-9.
1969: U Hornemann; M K Speedie; K M Kelley; Laurence H Hurley; H G Floss
Biosynthesis of indoleisopropionic acid by Claviceps. Biological C-methylation involving an intact methyl group.
Archives of biochemistry and biophysics 1969;131(2):430-40.