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Mikko Hurme

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Physiology

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Finland

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Young Adult

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Sjogren's Syndrome

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TOP 3
Juulia Jylhävä; Saara Marttila; Tapio Nevalainen; Antti Hervonen; Marja Jylhä; Mikko Hurme
Characterization of the role of distinct plasma cell-free DNA species in age-associated inflammation and frailty.
Taru Kuparinen; Saara Marttila; Pärt Peterson; Liina Tserel; Antti Hervonen; Marja Jylhä; Juulia Jylhävä; Mikko Hurme
Cytomegalovirus (CMV)-dependent and -independent changes in the aging of the human immune system: a transcriptomic analysis.
Kristiina Mansikkaniemi; Jukka Marniemi; Tapani Rönnemaa; Liisa Saarikoski; Simo Taimela; Leena Taittonen; Risto Telama; Jorma Viikari; Joelle Benessiano; Mirja Hirvensalo; Mikko Hurme; Risto Huupponen; Antti Jula; Markus Juonala; Mika Kähönen; Terho Lehtimäki; Ziad Mallat; Olli T Raitakari
Cross-sectional associations between physical activity and selected coronary heart disease risk factors in young adults. The Cardiovascular Risk in Young Finns Study.

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All Publications

2013: Juulia Jylhävä; Saara Marttila; Tapio Nevalainen; Antti Hervonen; Marja Jylhä; Mikko Hurme
Characterization of the role of distinct plasma cell-free DNA species in age-associated inflammation and frailty.
Aging cell 2013;12(3):388-97.
2013: Taru Kuparinen; Saara Marttila; Pärt Peterson; Liina Tserel; Antti Hervonen; Marja Jylhä; Juulia Jylhävä; Mikko Hurme
Cytomegalovirus (CMV)-dependent and -independent changes in the aging of the human immune system: a transcriptomic analysis.
Experimental gerontology 2013;48(3):305-12.
2012: Kristiina Mansikkaniemi; Jukka Marniemi; Tapani Rönnemaa; Liisa Saarikoski; Simo Taimela; Leena Taittonen; Risto Telama; Jorma Viikari; Joelle Benessiano; Mirja Hirvensalo; Mikko Hurme; Risto Huupponen; Antti Jula; Markus Juonala; Mika Kähönen; Terho Lehtimäki; Ziad Mallat; Olli T Raitakari
Cross-sectional associations between physical activity and selected coronary heart disease risk factors in young adults. The Cardiovascular Risk in Young Finns Study.
Annals of medicine 2012;44(7):733-44.
2012: Inna Lisko; Tiina Luukkaala; Sari Stenholm; Kristina Tiainen; Antti Hervonen; Mikko Hurme; Terho Lehtimäki; Marja Jylhä
Inflammation, adiposity, and mortality in the oldest old.
Rejuvenation research 2012;15(5):445-52.
2012: Vesa Lindström; Simo S Oja; Timo Paavonen; Janne Aittoniemi; Carita Eklund; Mikko Hurme; Maija Itälä-Remes; Juulia Jylhävä; Marjatta Sinisalo
Indoleamine 2,3-dioxygenase activity and expression in patients with chronic lymphocytic leukemia.
Clinical lymphoma, myeloma & leukemia 2012;12(5):363-5.
2012: T K Outinen; Ilkka Pörsti; J Sane; Jaana Syrjänen; Antti Vaheri; Heini Huhtala; Mikko Hurme; Satu Mäkelä; S Meri; Jukka Mustonen
High pentraxin-3 plasma levels associate with thrombocytopenia in acute Puumala hantavirus-induced nephropathia epidemica.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 2012;31(6):957-63.
2012: Juulia Jylhävä; Terho Lehtimäki; Antti Hervonen; Marja Jylhä; Mikko Hurme
Circulating cell-free DNA is associated with mortality and inflammatory markers in nonagenarians: the Vitality 90+ Study.
Experimental gerontology 2012;47(5):372-8.
2012: Reetta Huttunen; Janne Laine; Jaana Syrjänen; Risto Vuento; Mikko Hurme; Janne Aittoniemi
Apoptosis markers soluble Fas (sFas), Fas Ligand (FasL) and sFas/FasL ratio in patients with bacteremia: a prospective cohort study.
The Journal of infection 2012;64(3):276-81.
2012: A Haarala; Janne Aittoniemi; Nina Hutri-Kähönen; M Juonala; J Jylhävä; Mika Kähönen; T Laitinen; Terho Lehtimäki; O T Raitakari; Leena Taittonen; J Viikari; Mikko Hurme
Relation of high cytomegalovirus antibody titres to blood pressure and brachial artery flow-mediated dilation in young men: the Cardiovascular Risk in Young Finns Study.
Clinical and experimental immunology 2012;167(2):309-16.
2012: Juulia Jylhävä; Mika Kähönen; Johannes Kettunen; Terho Lehtimäki; Leo-Pekka Lyytikäinen; Olli T Raitakari; Jorma Viikari; Nina Hutri-Kähönen; Mikko Hurme
A genome-wide association study identifies UGT1A1 as a regulator of serum cell-free DNA in young adults: The Cardiovascular Risk in Young Finns Study.
PloS one 2012;7(4):e35426.
2012: Tuula K Outinen; Ilkka Pörsti; Jaana Syrjänen; Antti Vaheri; Juulia Jylhävä; Taru Kuparinen; Sonja Leppänen; Satu Mäkelä; Jukka Mustonen; Mikko Hurme
Plasma cell-free DNA levels are elevated in acute Puumala hantavirus infection.
PloS one 2012;7(2):e31455.
2011: Saara Marttila; Marko Pesu; Sanna Hämäläinen; Antti Hervonen; Marja Jylhä; Juulia Jylhävä; Mikko Hurme
IL-7 concentration is increased in nonagenarians but is not associated with markers of T cell immunosenescence.
Experimental gerontology 2011;46(12):1000-2.
2011: Marko Elovainio; Taina Hintsa; Mirka Hintsanen; Mikko Hurme; Markus Jokela; Mika Kivimäki; Terho Lehtimäki; Laura Pulkki-Råback; Olli T Raitakari; Jorma Viikari; Liisa Keltikangas-Järvinen
Moderating effect of indoleamine 2,3-dioxygenase (IDO) activation in the association between depressive symptoms and carotid atherosclerosis: evidence from the Young Finns study.
Journal of affective disorders 2011;133(3):611-4.
2011: Atte Haarala; Carita Eklund; Risto Huupponen; Juulia Jylhävä; Mika Kähönen; Tuomas Koskinen; Terho Lehtimäki; Olli T Raitakari; Leena Taittonen; Jorma Viikari; Mikko Hurme
Heart rate variability is independently associated with C-reactive protein but not with Serum amyloid A. The Cardiovascular Risk in Young Finns Study.
European journal of clinical investigation 2011;41(9):951-7.
2011: Teemu Honkanen; Heini Huhtala; Mikko Hurme; Jussi Karjalainen; M Lehtonen; A Luukkainen; J Myller; T Paavonen; Markus Rautiainen; S Toppila-Salmi
Indoleamine 2,3-dioxygenase expression is associated with chronic rhinosinusitis with nasal polyps and antrochoanal polyps.
Rhinology 2011;49(3):356-63.
2011: J Jylhävä; A Haarala; Mika Kähönen; Terho Lehtimäki; Antti Jula; Leena Moilanen; Y Antero Kesäniemi; Markku S Nieminen; Mikko Hurme
Pentraxin 3 (PTX3) is associated with cardiovascular risk factors: the Health 2000 Survey.
Clinical and experimental immunology 2011;164(2):211-7.
2011: Tuula K Outinen; Satu M Mäkelä; Ilpo Ala-Houhala; Heini S A Huhtala; Mikko Hurme; Daniel H Libraty; Simo S Oja; Ilkka Pörsti; Jaana Syrjänen; Antti Vaheri; Jukka T Mustonen
High activity of indoleamine 2,3-dioxygenase is associated with renal insufficiency in Puumala hantavirus induced nephropathia epidemica.
Journal of medical virology 2011;83(4):731-7.
2011: Saara Marttila; Carita Eklund; Antti Hervonen; Marja Jylhä; Juulia Jylhävä; Mikko Hurme
Aging-associated increase in indoleamine 2,3-dioxygenase (IDO) activity appears to be unrelated to the transcription of the IDO1 or IDO2 genes in peripheral blood mononuclear cells.
Immunity & ageing : I & A 2011;8():9.
2011: Reetta Huttunen; Juulia Jylhävä; Taru Kuparinen; Janne Laine; Jaana Syrjänen; Risto Vuento; Janne Aittoniemi; Heini Huhtala; Mikko Hurme
Fatal outcome in bacteremia is characterized by high plasma cell free DNA concentration and apoptotic DNA fragmentation: a prospective cohort study.
PloS one 2011;6(7):e21700.
2011: Reetta Huttunen; Mikko Hurme; Janne Aittoniemi; Heini Huhtala; Risto Vuento; Janne Laine; Juulia Jylhävä; Jaana Syrjänen
High plasma level of long pentraxin 3 (PTX3) is associated with fatal disease in bacteremic patients: a prospective cohort study.
PloS one 2011;6(3):e17653.
2011: Juulia Jylhävä; Tapio Kotipelto; Annika Raitala; Marja Jylhä; Antti Hervonen; Mikko Hurme
Aging is associated with quantitative and qualitative changes in circulating cell-free DNA: the Vitality 90+ study.
Mechanisms of ageing and development 2011;132(1-2):20-6.
2010: Juulia Jylhävä; Carita Eklund; Marja Jylhä; Antti Hervonen; Mikko Hurme
Expression profiling of immune-associated genes in peripheral blood mononuclear cells reveals baseline differences in co-stimulatory signalling between nonagenarians and younger controls: the vitality 90+ study.
Biogerontology 2010;11(6):671-7.
2010: Sebastian Okser; Terho Lehtimäki; Laura L Elo; Nina Mononen; Nina Peltonen; Mika Kähönen; Markus Juonala; Yue-Mei Fan; Jussi A Hernesniemi; Tomi Laitinen; Leo-Pekka Lyytikäinen; Riikka Rontu; Carita Eklund; Nina Hutri-Kähönen; Leena Taittonen; Mikko Hurme; Jorma S A Viikari; Olli T Raitakari; Tero Aittokallio
Genetic variants and their interactions in the prediction of increased pre-clinical carotid atherosclerosis: the cardiovascular risk in young Finns study.
PLoS genetics 2010;6(9):.
2010: Kristina Tiainen; Mikko Hurme; Antti Hervonen; Tiina Luukkaala; Marja Jylhä
Inflammatory markers and physical performance among nonagenarians.
The journals of gerontology. Series A, Biological sciences and medical sciences 2010;65(6):658-63.
2010: Satu Mäkelä; Pia Jaatinen; M Miettinen; Jorma Salmi; Ilpo Ala-Houhala; Heini Huhtala; Mikko Hurme; Ilkka Pörsti; A Vaheri; Jukka Mustonen
Hormonal deficiencies during and after Puumala hantavirus infection.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 2010;29(6):705-13.
2010: Reetta Huttunen; Jaana Syrjänen; Janne Aittoniemi; Simo S Oja; Annika Raitala; Janne Laine; Marja Pertovaara; Risto Vuento; Heini Huhtala; Mikko Hurme
High activity of indoleamine 2,3 dioxygenase enzyme predicts disease severity and case fatality in bacteremic patients.
Shock (Augusta, Ga.) 2010;33(2):149-54.
2010: Tuula K Outinen; Satu M Mäkelä; Ilpo Ala-Houhala; Heini Huhtala; Mikko Hurme; Antti S Paakkala; Ilkka Pörsti; Jaana Syrjänen; Jukka T Mustonen
The severity of Puumala hantavirus induced nephropathia epidemica can be better evaluated using plasma interleukin-6 than C-reactive protein determinations.
BMC infectious diseases 2010;10():132.
2010: Petri Niinisalo; Niku Oksala; Mari Levula; Markku Pelto-Huikko; Otso Järvinen; Juha-Pekka Salenius; Leena Kytömäki; Juhani T Soini; Mika Kähönen; Reijo Laaksonen; Mikko Hurme; Terho Lehtimäki
Activation of indoleamine 2,3-dioxygenase-induced tryptophan degradation in advanced atherosclerotic plaques: Tampere vascular study.
Annals of medicine 2010;42(1):55-63.
2010: Juulia Jylhävä; Mikko Hurme
Gene variants as determinants of longevity: focus on the inflammatory factors.
Pflügers Archiv : European journal of physiology 2010;459(2):239-46.
2010: Miikael Heiskanen; Mika Kähönen; Mikko Hurme; Terho Lehtimäki; Nina Mononen; Markus Juonala; Nina Hutri-Kähönen; Jorma Viikari; Olli Raitakari; Janne Hulkkonen
Polymorphism in the IL10 promoter region and early markers of atherosclerosis: the Cardiovascular Risk in Young Finns Study.
Atherosclerosis 2010;208(1):190-6.
2009: Marja Pertovaara; Mika Kähönen; Markus Juonala; Tomi Laitinen; Leena Taittonen; Terho Lehtimäki; Jorma S A Viikari; Olli T Raitakari; Mikko Hurme
Autoimmunity and atherosclerosis: the presence of antinuclear antibodies is associated with decreased carotid elasticity in young women. The Cardiovascular Risk in Young Finns Study.
Rheumatology (Oxford, England) 2009;48(12):1553-6.
2009: Jussi A Hernesniemi; Pekka J Karhunen; Niku Oksala; Mika Kähönen; Mari Levula; Riikka Rontu; Erkki Ilveskoski; Olli A Kajander; Sirkka Goebeler; Leena E Viiri; Mikko Hurme; Terho Lehtimäki
Interleukin 18 gene promoter polymorphism: a link between hypertension and pre-hospital sudden cardiac death: the Helsinki Sudden Death Study.
European heart journal 2009;30(23):2939-46.
2009: Marja Pertovaara; Juulia Jylhävä; Hannu Uusitalo; Juhani Pukander; Heikki Helin; Mikko Hurme
Serum amyloid A and C-reactive protein concentrations are differently associated with markers of autoimmunity in patients with primary Sjögren's syndrome.
The Journal of rheumatology 2009;36(11):2487-90.
2009: J Jylhävä; A Haarala; Carita Eklund; Marja Pertovaara; Mika Kähönen; Nina Hutri-Kähönen; Mari Levula; Terho Lehtimäki; R Huupponen; Antti Jula; Markus Juonala; Jorma Viikari; Olli Raitakari; Mikko Hurme
Serum amyloid A is independently associated with metabolic risk factors but not with early atherosclerosis: the Cardiovascular Risk in Young Finns Study.
Journal of internal medicine 2009;266(3):286-95.
2009: Carita Eklund; T L J Tammela; Johanna Schleutker; Mikko Hurme
C-reactive protein haplotype is associated with high PSA as a marker of metastatic prostate cancer but not with overall cancer risk.
British journal of cancer 2009;100(12):1846-51.
2009: Reetta Huttunen; Mikko Hurme; Janne Laine; Carita Eklund; Risto Vuento; Janne Aittoniemi; Heini Huhtala; Jaana Syrjänen
Endothelial nitric oxide synthase G894T (GLU298ASP) polymorphism is associated with hypotension in patients with E. coli bacteremia but not in bacteremia caused by a gram-positive organism.
Shock (Augusta, Ga.) 2009;31(5):448-53.
2009: Mikko Seppänen; Marja-Liisa Lokki; Maija Lappalainen; Eija Hiltunen-Back; Anja T Rovio; Saara Kares; Mikko Hurme; Janne Aittoniemi
Mannose-binding lectin 2 gene polymorphism in recurrent herpes simplex virus 2 infection.
Human immunology 2009;70(4):218-21.
2009: Juulia Jylhävä; Carita Eklund; Marja Jylhä; Antti Hervonen; Terho Lehtimäki; Pekka Karhunen; Mikko Hurme
Complement factor H 402His variant confers an increased mortality risk in Finnish nonagenarians: the Vitality 90+ study.
Experimental gerontology 2009;44(4):297-9.
2009: Tanja Pessi; Carita Eklund; Heini Huhtala; Olli T Raitakari; Markus Juonala; Mika Kähönen; J S A Viikari; Terho Lehtimäki; Mikko Hurme
CRP and FCGR2A genes have an epistatic effect on carotid artery intima-media thickness: the Cardiovascular Risk in Young Finns Study.
International journal of immunogenetics 2009;36(1):39-45.
2009: Atte Haarala; Carita Eklund; Tanja Pessi; Terho Lehtimäki; Risto Huupponen; Antti Jula; Jorma Viikari; Olli Raitakari; Mikko Hurme
Use of combined oral contraceptives alters metabolic determinants and genetic regulation of C-reactive protein. The Cardiovascular Risk in Young Finns Study.
Scandinavian journal of clinical and laboratory investigation 2009;69(2):168-74.
2008: Miia Virta; Tanja Pessi; Merja Helminen; Tapio Seiskari; Anita Kondrashova; Mikael Knip; Heikki Hyöty; Mikko Hurme
Interaction between CD14-159C>T polymorphism and Helicobacter pylori is associated with serum total immunoglobulin E.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2008;38(12):1929-34.
2008: R Huttunen; Janne Aittoniemi; Janne Laine; Risto Vuento; Jussi Karjalainen; Anja T Rovio; C Eklund; Mikko Hurme; Heini Huhtala; Jaana Syrjänen
Gene-environment interaction between MBL2 genotype and smoking, and the risk of gram-positive bacteraemia.
Scandinavian journal of immunology 2008;68(4):438-44.
2008: Kaija Huuhka; Olli Kampman; Sisko Anttila; Martti Huuhka; Riikka Rontu; Kari M Mattila; Mikko Hurme; Terho Lehtimäki; Esa Leinonen
RGS4 polymorphism and response to electroconvulsive therapy in major depressive disorder.
Neuroscience letters 2008;437(1):25-8.
2008: Merja Helminen; Mikko Hurme; Matti Korppi
Cytokine gene polymorphism in respiratory syncytial virus bronchiolitis.
The Pediatric infectious disease journal 2008;27(5):478-9.
2008: Merja Helminen; Kirsi Nuolivirta; Miia Virta; Anne Halkosalo; Matti Korppi; Timo Vesikari; Mikko Hurme
IL-10 gene polymorphism at -1082 A/G is associated with severe rhinovirus bronchiolitis in infants.
Pediatric pulmonology 2008;43(4):391-5.
2008: David Gimeno; Jane E Ferrie; Marko Elovainio; L Pulkki-Raback; L Keltikangas-Jarvinen; Carita Eklund; Mikko Hurme; Terho Lehtimäki; Jukka Marniemi; Jorma S A Viikari; Olli T Raitakari; Mika Kivimäki
When do social inequalities in C-reactive protein start? A life course perspective from conception to adulthood in the Cardiovascular Risk in Young Finns Study.
International journal of epidemiology 2008;37(2):290-8.
2008: Kati Kaartinen; Jaana Syrjänen; Ilkka Pörsti; Mikko Hurme; Aimo Harmoinen; Amos Pasternack; Heini Huhtala; Jukka Mustonen
Inflammatory markers and the progression of IgA glomerulonephritis.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2008;23(4):1285-90.
2008: Kai Lehtimäki; Tapani Keränen; Martti Huuhka; Johanna Palmio; Mikko Hurme; Esa Leinonen; Jukka Peltola
Increase in plasma proinflammatory cytokines after electroconvulsive therapy in patients with depressive disorder.
The journal of ECT 2008;24(1):88-91.
2008: Kari Hänninen; Heikki Katila; Marika Saarela; Riikka Rontu; Kari M Mattila; Meng Fan; Mikko Hurme; Terho Lehtimäki
Interleukin-1 beta gene polymorphism and its interactions with neuregulin-1 gene polymorphism are associated with schizophrenia.
European archives of psychiatry and clinical neuroscience 2008;258(1):10-5.
2008: Jussi A Hernesniemi; Pekka J Karhunen; Riikka Rontu; Erkki Ilveskoski; Olli A Kajander; Sirkka Goebeler; Leena E Viiri; Tanja Pessi; Mikko Hurme; Terho Lehtimäki
Interleukin-18 promoter polymorphism associates with the occurrence of sudden cardiac death among Caucasian males: the Helsinki Sudden Death Study.
Atherosclerosis 2008;196(2):643-9.
2008: Carita Eklund; M Kivimäki; Md Shaheenul Islam; Markus Juonala; Mika Kähönen; Jukka Marniemi; Terho Lehtimäki; Jorma Viikari; Olli T Raitakari; Mikko Hurme
C-reactive protein genetics is associated with carotid artery compliance in men in The Cardiovascular Risk in Young Finns Study.
Atherosclerosis 2008;196(2):841-8.
2008: P Niinisalo; Annika Raitala; Marja Pertovaara; Simo S Oja; T Lehtimäki; M Kähönen; Antti Reunanen; Antti Jula; Leena Moilanen; Y A Kesäniemi; Markku S Nieminen; Mikko Hurme
Indoleamine 2,3-dioxygenase activity associates with cardiovascular risk factors: the Health 2000 study.
Scandinavian journal of clinical and laboratory investigation 2008;68(8):767-70.
2008: Antti Paakkala; Satu Mäkelä; Mikko Hurme; Jukka Partanen; Heini Huhtala; Jukka Mustonen
Association of chest radiography findings with host-related genetic factors in patients with nephropathia epidemica.
Scandinavian journal of infectious diseases 2008;40(3):254-8.
2007: Liisa A Viikari; Risto Huupponen; Jorma S A Viikari; Jukka Marniemi; Carita Eklund; Mikko Hurme; Terho Lehtimäki; Mika Kivimäki; Olli T Raitakari
Relationship between leptin and C-reactive protein in young Finnish adults.
The Journal of clinical endocrinology and metabolism 2007;92(12):4753-8.
2007: Marja Pertovaara; T Hasan; Annika Raitala; Simo S Oja; U Yli-Kerttula; Markku Korpela; Mikko Hurme
Indoleamine 2,3-dioxygenase activity is increased in patients with systemic lupus erythematosus and predicts disease activation in the sunny season.
Clinical and experimental immunology 2007;150(2):274-8.
2007: Marja Pertovaara; Jaakko Antonen; Mikko Hurme
Endothelial nitric oxide synthase +894 polymorphism is associated with recurrent salivary gland swelling and early onset in patients with primary Sjogren's syndrome.
Annals of the rheumatic diseases 2007;66(10):1400-1.
2007: KA Lehtimäki; Tapani Keränen; Johanna Palmio; R Mäkinen; Mikko Hurme; Jari Honkaniemi; Jukka Peltola
Increased plasma levels of cytokines after seizures in localization-related epilepsy.
Acta neurologica Scandinavica 2007;116(4):226-30.
2007: Mikko Hurme; M Kivimäki; Marja Pertovaara; Terho Lehtimäki; Pekka J Karhunen; Marja Jylhä; Antti Hervonen; Carita Eklund
CRP gene is involved in the regulation of human longevity: a follow-up study in Finnish nonagenarians.
Mechanisms of ageing and development 2007;128(10):574-6.
2007: Mika Kivimäki; Debbie A Lawlor; George Davey Smith; Carita Eklund; Mikko Hurme; Terho Lehtimäki; Jorma S A Viikari; Olli T Raitakari
Variants in the CRP gene as a measure of lifelong differences in average C-reactive protein levels: the Cardiovascular Risk in Young Finns Study, 1980-2001.
American journal of epidemiology 2007;166(7):760-4.
2007: Marja Jylhä; Paula Paavilainen; Terho Lehtimäki; Sirkka Goebeler; Pekka J Karhunen; Antti Hervonen; Mikko Hurme
Interleukin-1 receptor antagonist, interleukin-6, and C-reactive protein as predictors of mortality in nonagenarians: the vitality 90+ study.
The journals of gerontology. Series A, Biological sciences and medical sciences 2007;62(9):1016-21.
2007: Ari Illi; Olli Kampman; Kari Hänninen; Sisko Anttila; Kari M Mattila; Heikki Katila; Riikka Rontu; Mikko Hurme; Terho Lehtimäki; Esa Leinonen
Catechol-O-methyltransferase val108/158met genotype and response to antipsychotic medication in schizophrenia.
Human psychopharmacology 2007;22(4):211-5.
2007: Mikko Hurme; S Korkki; Terho Lehtimäki; Pekka J Karhunen; Marja Jylhä; Antti Hervonen; Marja Pertovaara
Autoimmunity and longevity: presence of antinuclear antibodies is not associated with the rate of inflammation or mortality in nonagenarians.
Mechanisms of ageing and development 2007;128(5-6):407-8.
2007: Mika Kivimäki; Debbie A Lawlor; Carita Eklund; George Davey Smith; Mikko Hurme; Terho Lehtimäki; Jorma S A Viikari; Olli T Raitakari
Mendelian randomization suggests no causal association between C-reactive protein and carotid intima-media thickness in the young Finns study.
Arteriosclerosis, thrombosis, and vascular biology 2007;27(4):978-9.
2007: Marja Pertovaara; Annika Raitala; Markus Juonala; Terho Lehtimäki; Heini Huhtala; Simo S Oja; Eero Jokinen; Jorma S A Viikari; Olli T Raitakari; Mikko Hurme
Indoleamine 2,3-dioxygenase enzyme activity correlates with risk factors for atherosclerosis: the Cardiovascular Risk in Young Finns Study.
Clinical and experimental immunology 2007;148(1):106-11.
2007: Tapio Seiskari; Anita Kondrashova; Hanna Viskari; Minna Kaila; AM Haapala; Janne Aittoniemi; Miia Virta; Mikko Hurme; Raivo Uibo; Mikael Knip; Heikki Hyöty
Allergic sensitization and microbial load--a comparison between Finland and Russian Karelia.
Clinical and experimental immunology 2007;148(1):47-52.
2007: Terho Lehtimäki; Antti Hervonen; Riikka Rontu; Pekka Karhunen; Marja Jylhä; Mikko Hurme
Survival related to plasma C-reactive-protein in nonagenarians is modified by apolipoprotein E genotype.
Clinical chemistry 2007;53(2):365-7.
2007: Marja Pertovaara; Annika Raitala; Markus Juonala; Mika Kähönen; Terho Lehtimäki; Jorma S A Viikari; Olli T Raitakari; Mikko Hurme
Autoimmunity and atherosclerosis: functional polymorphism of PTPN22 is associated with phenotypes related to the risk of atherosclerosis. The Cardiovascular Risk in Young Finns Study.
Clinical and experimental immunology 2007;147(2):265-9.
2007: Annika Raitala; Jussi Karjalainen; Simo S Oja; Timo U Kosunen; Mikko Hurme
Helicobacter pylori-induced indoleamine 2,3-dioxygenase activity in vivo is regulated by TGFB1 and CTLA4 polymorphisms.
Molecular immunology 2007;44(5):1011-4.
2007: Mari Luomala; Reijo Laaksonen; Tuula Janatuinen; Risto Vesalainen; Pirjo Nuutila; Marika Saarela; Kari Mattila; M Kalijärvi; Tiina Solakivi; Juhani Knuuti; Mikko Hurme; Terho Lehtimäki
High plasma levels of CD40 are associated with low coenzyme Q and vitamin E content of low-density lipoprotein in healthy men.
Scandinavian journal of clinical and laboratory investigation 2007;67(2):115-22.
2007: Kari Hänninen; Heikki Katila; Sisko Anttila; Riikka Rontu; Julius Maaskola; Mikko Hurme; Terho Lehtimäki
Epidermal growth factor a61g polymorphism is associated with the age of onset of schizophrenia in male patients.
Journal of psychiatric research 2007;41(1-2):8-14.
2006: Kari Hänninen; Heikki Katila; Olli Kampman; Sisko Anttila; Ari Illi; Riikka Rontu; Kari M Mattila; Jarmo Hietala; Mikko Hurme; Esa Leinonen; Terho Lehtimäki
Association between the C957T polymorphism of the dopamine D2 receptor gene and schizophrenia.
Neuroscience letters 2006;407(3):195-8.
2006: Marja Pertovaara; Markku Heliövaara; Annika Raitala; Simo S Oja; Paul Knekt; Mikko Hurme
The activity of the immunoregulatory enzyme indoleamine 2,3-dioxygenase is decreased in smokers.
Clinical and experimental immunology 2006;145(3):469-73.
2006: Tanja Pessi; Kati Adjers; Jussi Karjalainen; Riikka Rontu; Mikko Hurme
The interaction of IL1A and endothelial nitric oxide synthase polymorphisms is associated with the degree of atopy.
The Journal of allergy and clinical immunology 2006;118(1):284-6.
2006: Carita Eklund; Arja Nenonen; Katriina Kukkonen-Harjula; Patrik T Borg; Mikael Fogelholm; Seppo Laine; Heini Huhtala; Terho Lehtimäki; Mikko Hurme
Association of the IL6-174(G/C) polymorphism with C-reactive protein concentration after weight loss in obese men.
European cytokine network 2006;17(2):131-5.
2006: Marja Pertovaara; Annika Raitala; Terho Lehtimäki; Pekka J Karhunen; Simo S Oja; Marja Jylhä; Antti Hervonen; Mikko Hurme
Indoleamine 2,3-dioxygenase activity in nonagenarians is markedly increased and predicts mortality.
Mechanisms of ageing and development 2006;127(5):497-9.
2006: Marja Pertovaara; Jaakko Antonen; Mikko Hurme
Th2 cytokine genotypes are associated with a milder form of primary Sjogren's syndrome.
Annals of the rheumatic diseases 2006;65(5):666-70.
2006: Riikka Rontu; Petri Ojala; Antti Hervonen; Sirkka Goebeler; Pekka J Karhunen; Matti Nikkilä; Tarja A Kunnas; Marja Jylhä; Carita Eklund; Mikko Hurme; Terho Lehtimäki
Apolipoprotein E genotype is related to plasma levels of C-reactive protein and lipids and to longevity in nonagenarians.
Clinical endocrinology 2006;64(3):265-70.
2006: Annika Raitala; Jussi Karjalainen; Simo S Oja; Timo U Kosunen; Mikko Hurme
Indoleamine 2,3-dioxygenase (IDO) activity is lower in atopic than in non-atopic individuals and is enhanced by environmental factors protecting from atopy.
Molecular immunology 2006;43(7):1054-6.
2006: Carita Eklund; Reetta Huttunen; Jaana Syrjänen; Janne Laine; Risto Vuento; Mikko Hurme
Polymorphism of the C-reactive protein gene is associated with mortality in bacteraemia.
Scandinavian journal of infectious diseases 2006;38(11-12):1069-73.
2006: J Hernesniemi; Terho Lehtimäki; Riikka Rontu; M S Islam; Carita Eklund; Jussi Mikkelsson; Erkki Ilveskoski; Olli A Kajander; Sirkka Goebeler; Leena E Viiri; Mikko Hurme; Pekka J Karhunen
Toll-like receptor 4 polymorphism is associated with coronary stenosis but not with the occurrence of acute or old myocardial infarctions.
Scandinavian journal of clinical and laboratory investigation 2006;66(8):667-75.
2006: Petra Kiszel; George Füst; Tanja Pessi; Mikko Hurme; Zoltan Prohaszka
Associations between interleukin-6 genetic polymorphisms and levels of autoantibodies to 60-kDa heat-shock proteins.
Human heredity 2006;62(2):77-83.
2005: Kati Adjers; Jussi Karjalainen; Tanja Pessi; Carita Eklund; Mikko Hurme
Epistatic effect of TLR4 and IL4 genes on the risk of asthma in females.
International archives of allergy and immunology 2005;138(3):251-6.
2005: Marja Pertovaara; Annika Raitala; H Uusitalo; Juhani Pukander; H Helin; Simo S Oja; Mikko Hurme
Mechanisms dependent on tryptophan catabolism regulate immune responses in primary Sjögren's syndrome.
Clinical and experimental immunology 2005;142(1):155-61.
2005: Janne Aittoniemi; H Soranummi; A T Rovio; Mikko Hurme; Tanja Pessi; M Nieminen; Jussi Karjalainen
Mannose-binding lectin 2 (MBL2) gene polymorphism in asthma and atopy among adults.
Clinical and experimental immunology 2005;142(1):120-4.
2005: Kari Hänninen; Heikki Katila; Riikka Rontu; Kari M Mattila; Mikko Hurme; Terho Lehtimäki
Tumor necrosis factor-alpha --G308A polymorphism in schizophrenia in a Finnish population.
Neuroscience letters 2005;385(1):76-81.
2005: Terho Lehtimäki; Petri Ojala; Riikka Rontu; Sirkka Goebeler; Pekka J Karhunen; Marja Jylhä; Kari Mattila; Saara Metso; Hannu Jokela; Matti Nikkilä; Erkki Wuolijoki; Antti Hervonen; Mikko Hurme
Interleukin-6 modulates plasma cholesterol and C-reactive protein concentrations in nonagenarians.
Journal of the American Geriatrics Society 2005;53(9):1552-8.
2005: Carita Eklund; Terho Lehtimäki; Mikko Hurme
Epistatic effect of C-reactive protein (CRP) single nucleotide polymorphism (SNP) +1059 and interleukin-1B SNP +3954 on CRP concentration in healthy male blood donors.
International journal of immunogenetics 2005;32(4):229-32.
2005: Tanja Pessi; Miia Virta; Kati Adjers; Jussi Karjalainen; H Rautelin; Timo U Kosunen; Mikko Hurme
Genetic and environmental factors in the immunopathogenesis of atopy: interaction of Helicobacter pylori infection and IL4 genetics.
International archives of allergy and immunology 2005;137(4):282-8.
2005: Jussi Karjalainen; Miia Virta; Tanja Pessi; Janne Hulkkonen; Markku M Nieminen; Mikko Hurme
Childhood cat exposure-related tolerance is associated with IL1A and IL10 polymorphisms.
The Journal of allergy and clinical immunology 2005;116(1):223-5.
2005: Juhani Vilpo; Gerard Tobin; Janne Hulkkonen; Mikko Hurme; Ulf Thunberg; Christer Sundström; Leena Vilpo; Richard Rosenquist
Mitogen induced activation, proliferation and surface antigen expression patterns in unmutated and hypermutated chronic lymphocytic leukemia cells.
European journal of haematology 2005;75(1):34-40.
2005: Mikko Hurme; Paula M Paavilainen; Marja Pertovaara; Marja Jylhä; Pekka J Karhunen; Antti Hervonen; Terho Lehtimäki
IgA levels are predictors of mortality in Finnish nonagenarians.
Mechanisms of ageing and development 2005;126(6-7):829-31.
2005: Teemu Honkanen; Jukka Mustonen; Heikki Kainulainen; Juhani Myllymäki; Pekka Collin; Mikko Hurme; Immo Rantala
Small bowel cyclooxygenase 2 (COX-2) expression in patients with IgA nephropathy.
Kidney international 2005;67(6):2187-95.
2005: Annika Raitala; Marja Pertovaara; Jussi Karjalainen; Simo S Oja; Mikko Hurme
Association of interferon-gamma +874(T/A) single nucleotide polymorphism with the rate of tryptophan catabolism in healthy individuals.
Scandinavian journal of immunology 2005;61(4):387-90.
2005: Mikko Hurme; Terho Lehtimäki; Marja Jylhä; Pekka J Karhunen; Antti Hervonen
Interleukin-6 -174G/C polymorphism and longevity: a follow-up study.
Mechanisms of ageing and development 2005;126(3):417-8.
2005: Anna-Kaisa Niemi; Jukka S Moilanen; Masashi Tanaka; Antti Hervonen; Mikko Hurme; Terho Lehtimäki; Yasumichi Arai; Nobuyoshi Hirose; Kari Majamaa
A combination of three common inherited mitochondrial DNA polymorphisms promotes longevity in Finnish and Japanese subjects.
European journal of human genetics : EJHG 2005;13(2):166-70.
2005: Maritta Pykäläinen; Riikka Kinos; Sanna Valkonen; Pia Rydman; Maritta Kilpeläinen; Lauri A Laitinen; Jussi Karjalainen; Markku Nieminen; Mikko Hurme; Juha Kere; Tarja Laitinen; Riitta Lahesmaa
Association analysis of common variants of STAT6, GATA3, and STAT4 to asthma and high serum IgE phenotypes.
The Journal of allergy and clinical immunology 2005;115(1):80-7.
2004: Marja Pertovaara; Terho Lehtimäki; Riikka Rontu; Jaakko Antonen; Amos Pasternack; Mikko Hurme
Presence of apolipoprotein E epsilon4 allele predisposes to early onset of primary Sjogren's syndrome.
Rheumatology (Oxford, England) 2004;43(12):1484-7.
2004: Janne Hulkkonen; Marja Pertovaara; Jaakko Antonen; Amos Pasternack; Mikko Hurme; Perttu J Pöllänen; Terho Lehtimäki
Matrix metalloproteinase 9 (MMP-9) gene polymorphism and MMP-9 plasma levels in primary Sjogren's syndrome.
Rheumatology (Oxford, England) 2004;43(12):1476-9.
2004: Marja Pertovaara; Mikko Hurme; Jaakko Antonen; Amos Pasternack; Janardan P Pandey
Immunoglobulin KM and GM gene polymorphisms modify the clinical presentation of primary Sjögren's syndrome.
The Journal of rheumatology 2004;31(11):2175-80.
2004: Janne Aittoniemi; Yue-Mei Fan; Reijo Laaksonen; Tuula Janatuinen; Risto Vesalainen; Pirjo Nuutila; Juhani Knuuti; Janne Hulkkonen; Mikko Hurme; Terho Lehtimäki
The effect of mannan-binding lectin variant alleles on coronary artery reactivity in healthy young men.
International journal of cardiology 2004;97(2):317-8.
2004: KA Lehtimäki; Tapani Keränen; H Huhtala; Mikko Hurme; J Ollikainen; Jari Honkaniemi; Johanna Palmio; Jukka Peltola
Regulation of IL-6 system in cerebrospinal fluid and serum compartments by seizures: the effect of seizure type and duration.
Journal of neuroimmunology 2004;152(1-2):121-5.
2004: Satu Mäkelä; Jukka Mustonen; Ilpo Ala-Houhala; Mikko Hurme; Anna-Maija Koivisto; Antti Vaheri; Amos Pasternack
Urinary excretion of interleukin-6 correlates with proteinuria in acute Puumala hantavirus-induced nephritis.
American journal of kidney diseases : the official journal of the National Kidney Foundation 2004;43(5):809-16.
2004: Janne Hulkkonen; Elina Koskikallio; Sirpa Rainesalo; Tapani Keränen; Mikko Hurme; Jukka Peltola
The balance of inhibitory and excitatory cytokines is differently regulated in vivo and in vitro among therapy resistant epilepsy patients.
Epilepsy research 2004;59(2-3):199-205.
2004: Kati Adjers; Tanja Pessi; Jussi Karjalainen; Heini Huhtala; Mikko Hurme
Epistatic effect of IL1A and IL4RA genes on the risk of atopy.
The Journal of allergy and clinical immunology 2004;113(3):445-7.
2004: Janardan P Pandey; Zoltan Prohaszka ; Amarilla Veres; George Füst; Mikko Hurme
Epistatic effects of genes encoding immunoglobulin GM allotypes and interleukin-6 on the production of autoantibodies to 60- and 65-kDa heat-shock proteins.
Genes and immunity 2004;5(1):68-71.
2004: Marja Pertovaara; Janne Hulkkonen; Jaakko Antonen; P Holopainen; Pekka Laippala; Amos Pasternack; Mikko Hurme
Polymorphism of the tumour necrosis factor-alpha gene at position -308 and renal manifestations of primary Sjögren's syndrome.
Rheumatology (Oxford, England) 2004;43(1):106-7.
2003: Sari Iltanen; Markku Mäki; Pekka Collin; Kirsi Mustalahti; Katri Kaukinen; Jukka Partanen; Janne Hulkkonen; Mikko Hurme; Janne Aittoniemi
The association between mannan-binding lectin gene alleles and celiac disease.
The American journal of gastroenterology 2003;98(12):2808-9.
2003: Mari Luomala; Terho Lehtimäki; H Huhtala; Maritta Ukkonen; Timo Koivula; Mikko Hurme; Irina Elovaara
Promoter polymorphism of IL-10 and severity of multiple sclerosis.
Acta neurologica Scandinavica 2003;108(6):396-400.
2003: Terho Lehtimäki; Reijo Laaksonen; Tuula Janatuinen; Risto Vesalainen; Pirjo Nuutila; Kari Mattila; Erkki Ilveskoski; Mari Luomala; Pekka Saikku; Juhani Knuuti; Mikko Hurme
Interleukin-1B genotype modulates the improvement of coronary artery reactivity by lipid-lowering therapy with pravastatin: a placebo-controlled positron emission tomography study in young healthy men.
Pharmacogenetics 2003;13(10):633-9.
2003: Veli-Pekka Joki-Erkkilä; Jussi Karjalainen; Janne Hulkkonen; Tanja Pessi; Markku M Nieminen; Arpo Aromaa; Timo Klaukka; Mikko Hurme
Allergic rhinitis and polymorphisms of the interleukin 1 gene complex.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 2003;91(3):275-9.
2003: Carita Eklund; Farhana Jahan; Tanja Pessi; Terho Lehtimäki; Mikko Hurme
Interleukin 1B gene polymorphism is associated with baseline C-reactive protein levels in healthy individuals.
European cytokine network 2003;14(3):168-71.
2003: Jussi Karjalainen; Veli-Pekka Joki-Erkkilä; Janne Hulkkonen; Tanja Pessi; Markku M Nieminen; Arpo Aromaa; Timo Klaukka; Mikko Hurme
The IL1A genotype is associated with nasal polyposis in asthmatic adults.
Allergy 2003;58(5):393-6.
2003: Tanja Pessi; Jussi Karjalainen; Janne Hulkkonen; Markku M Nieminen; Mikko Hurme
A common IL-1 complex haplotype is associated with an increased risk of atopy.
Journal of medical genetics 2003;40(5):e66.
2003: Sanna Kilpinen; Seppo Laine; Janne Hulkkonen; Mikko Hurme
Immunoglobulin G3 and immunoglobulin M isotype plasma levels are influenced by interleukin-1alpha genotype.
Scandinavian journal of immunology 2003;57(3):296-302.
2003: Jari Karhukorpi; Tarja Laitinen; Helena Kivelä; Anja Tiilikainen; Mikko Hurme
IL-1 receptor antagonist gene polymorphism in recurrent spontaneous abortion.
Journal of reproductive immunology 2003;58(1):61-7.
2003: Mikko Hurme; Tanja Pessi; Jussi Karjalainen
Genetics of inflammation and atopy.
Annals of medicine 2003;35(4):256-8.
2003: Olli Silvennoinen; Mikko Hurme
[New knowledge about cytokines].
Duodecim; lääketieteellinen aikakauskirja 2003;119(8):773-9.
2003: Juhani Vilpo; Gerard Tobin; Janne Hulkkonen; Mikko Hurme; Ulf Thunberg; Christer Sundström; Leena Vilpo; Richard Rosenquist
Surface antigen expression and correlation with variable heavy-chain gene mutation status in chronic lymphocytic leukemia.
European journal of haematology 2003;70(1):53-9.
2003: Mikko Hurme; Maija Haanpää; Turo Nurmikko; X-Y Wang; Miia Virta; Tanja Pessi; Sanna Kilpinen; Janne Hulkkonen; Merja Helminen
IL-10 gene polymorphism and herpesvirus infections.
Journal of medical virology 2003;70 Suppl 1():S48-50.
2003: Jussi Karjalainen; Janne Hulkkonen; Markku M Nieminen; Heini Huhtala; Arpo Aromaa; Timo Klaukka; Mikko Hurme
Interleukin-10 gene promoter region polymorphism is associated with eosinophil count and circulating immunoglobulin E in adult asthma.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2003;33(1):78-83.
2003: Anna-Kaisa Niemi; Antti Hervonen; Mikko Hurme; Pekka J Karhunen; Marja Jylhä; Kari Majamaa
Mitochondrial DNA polymorphisms associated with longevity in a Finnish population.
Human genetics 2003;112(1):29-33.
2002: Janne Hulkkonen; Marja Pertovaara; Jaakko Antonen; Amos Pasternack; Mikko Hurme
IL-1 gene family haplotypes and Raynaud's phenomenon in primary Sjögren's syndrome.
Rheumatology (Oxford, England) 2002;41(10):1206-8.
2002: Satu Mäkelä; Jukka Mustonen; Ilpo Ala-Houhala; Mikko Hurme; Jukka Partanen; Olli Vapalahti; Antti Vaheri; Amos Pasternack
Human leukocyte antigen-B8-DR3 is a more important risk factor for severe Puumala hantavirus infection than the tumor necrosis factor-alpha(-308) G/A polymorphism.
The Journal of infectious diseases 2002;186(6):843-6.
2002: Jussi Karjalainen; Janne Hulkkonen; Tanja Pessi; Heini Huhtala; Markku M Nieminen; Arpo Aromaa; Timo Klaukka; Mikko Hurme
The IL1A genotype associates with atopy in nonasthmatic adults.
The Journal of allergy and clinical immunology 2002;110(3):429-34.
2002: Juhani Vilpo; Janne Hulkkonen; Mikko Hurme; Leena Vilpo
Surface membrane antigen expression changes induced in vitro by exogenous growth factors in chronic lymphocytic leukemia cells.
Leukemia 2002;16(9):1691-8.
2002: Miia Virta; Mikko Hurme; Merja Helminen
Increased plasma levels of pro- and anti-inflammatory cytokines in patients with febrile seizures.
Epilepsia 2002;43(8):920-3.
2002: Ilkka Kivekäs; Janne Hulkkonen; Mikko Hurme; Leena Vilpo; Juhani Vilpo
CD80 antigen expression as a predictor of ex vivo chemosensitivity in chronic lymphocytic leukemia.
Leukemia research 2002;26(5):443-6.
2002: Miia Virta; Mikko Hurme; Merja Helminen
Increased frequency of interleukin-1beta (-511) allele 2 in febrile seizures.
Pediatric neurology 2002;26(3):192-5.
2002: Jussi Karjalainen; Markku M Nieminen; Arpo Aromaa; Timo Klaukka; Mikko Hurme
The IL-1beta genotype carries asthma susceptibility only in men.
The Journal of allergy and clinical immunology 2002;109(3):514-6.
2002: Jaana Syrjänen; Mikko Hurme; Terho Lehtimäki; Jukka Mustonen; Amos Pasternack
Polymorphism of the cytokine genes and IgA nephropathy.
Kidney international 2002;61(3):1079-85.
2002: Amarilla Veres; Zoltan Prohaszka ; Sanna Kilpinen; Mahavir Singh; George Füst; Mikko Hurme
The promoter polymorphism of the IL-6 gene is associated with levels of antibodies to 60-kDa heat-shock proteins.
Immunogenetics 2002;53(10-11):851-6.
2002: Janne Hulkkonen; Leena Vilpo; Mikko Hurme; Juhani Vilpo
Surface antigen expression in chronic lymphocytic leukemia: clustering analysis, interrelationships and effects of chromosomal abnormalities.
Leukemia 2002;16(2):178-85.
2002: Janne Aittoniemi; Marja Pertovaara; Janne Hulkkonen; Amos Pasternack; Mikko Hurme; Pekka Laippala; Jaakko Antonen
The significance of mannan-binding lectin gene alleles in patients with primary Sjögren's syndrome.
Scandinavian journal of rheumatology 2002;31(6):362-5.
2002: Sanna Kilpinen; Heini Huhtala; Mikko Hurme
The combination of the interleukin-1alpha (IL-1alpha-889) genotype and the interleukin-10 (IL-10 ATA) haplotype is associated with increased interleukin-10 (IL-10) plasma levels in healthy individuals.
European cytokine network 2002;13(1):66-71.
2002: Maija Haanpää; Turo Nurmikko; Mikko Hurme
Polymorphism of the IL-10 gene is associated with susceptibility to herpes zoster.
Scandinavian journal of infectious diseases 2002;34(2):112-4.
2002: Jukka Peltola; J Laaksonen; Anna-Maija Haapala; Mikko Hurme; Sirpa Rainesalo; Tapani Keränen
Indicators of inflammation after recent tonic-clonic epileptic seizures correlate with plasma interleukin-6 levels.
Seizure : the journal of the British Epilepsy Association 2002;11(1):44-6.
2002: Veli-Pekka Joki-Erkkilä; Heikki J Puhakka; Mikko Hurme
Cytokine gene polymorphism in recurrent acute otitis media.
Archives of otolaryngology--head & neck surgery 2002;128(1):17-20.
2001: X Y Wang; Mikko Hurme; Marja Jylhä; Antti Hervonen
Lack of association between human longevity and polymorphisms of IL-1 cluster, IL-6, IL-10 and TNF-alpha genes in Finnish nonagenarians.
Mechanisms of ageing and development 2001;123(1):29-38.
2001: Merja Helminen; Sanna Kilpinen; Miia Virta; Mikko Hurme
Susceptibility to primary Epstein-Barr virus infection is associated with interleukin-10 gene promoter polymorphism.
The Journal of infectious diseases 2001;184(6):777-80.
2001: Jukka Peltola; Tapani Keränen; Sirpa Rainesalo; Mikko Hurme
Polymorphism of the interleukin-1 gene complex in localization-related epilepsy.
Annals of neurology 2001;50(2):275-6.
2001: Satu Mäkelä; Mikko Hurme; Ilpo Ala-Houhala; Jukka Mustonen; Anna-Maija Koivisto; Jukka Partanen; Olli Vapalahti; Antti Vaheri; Amos Pasternack
Polymorphism of the cytokine genes in hospitalized patients with Puumala hantavirus infection.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2001;16(7):1368-73.
2001: Immo Rantala; Jukka Mustonen; Mikko Hurme; Jaana Syrjänen; Heikki Helin
Pathogenetic aspects of IgA nephropathy.
Nephron 2001;88(3):193-8.
2001: K Luotola; P Mantula; Jorma Salmi; Anna-Maija Haapala; Pekka Laippala; Mikko Hurme
Allele 2 of interleukin-1 receptor antagonist gene increases the risk of thyroid peroxidase antibodies in subacute thyroiditis.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2001;109(6):454-60.
2001: Jaakko Antonen; Heikki Saha; Mikko Hurme; Amos Pasternack
IL-6 may be the key mediator in trimethoprim-induced systemic adverse reaction and aseptic meningitis: a reply to Muller et al.
Clinical nephrology 2001;55(6):489-90.
2001: Janne Hulkkonen; Marja Pertovaara; Jaakko Antonen; Amos Pasternack; Mikko Hurme
Elevated interleukin-6 plasma levels are regulated by the promoter region polymorphism of the IL6 gene in primary Sjögren's syndrome and correlate with the clinical manifestations of the disease.
Rheumatology (Oxford, England) 2001;40(6):656-61.
2001: Mari Luomala; Terho Lehtimäki; Irina Elovaara; X Wang; Maritta Ukkonen; Kari Mattila; Pekka Laippala; Timo Koivula; Mikko Hurme
A study of interleukin-1 cluster genes in susceptibility to and severity of multiple sclerosis.
Journal of the neurological sciences 2001;185(2):123-7.
2001: Sanna Kilpinen; Janne Hulkkonen; X Y Wang; Mikko Hurme
The promoter polymorphism of the interleukin-6 gene regulates interleukin-6 production in neonates but not in adults.
European cytokine network 2001;12(1):62-8.
2001: T Keso; Markus Perola; Pekka Laippala; Erkki Ilveskoski; Tarja A Kunnas; Jussi Mikkelsson; Antti Penttilä; Mikko Hurme; Pekka J Karhunen
Polymorphisms within the tumor necrosis factor locus and prevalence of coronary artery disease in middle-aged men.
Atherosclerosis 2001;154(3):691-7.
2001: T Pessi; Erika Isolauri; Y Sütas; H Kankaanranta; Eeva Moilanen; Mikko Hurme
Suppression of T-cell activation by Lactobacillus rhamnosus GG-degraded bovine casein.
International immunopharmacology 2001;1(2):211-8.
2001: Janne Hulkkonen; Marja Pertovaara; Jaakko Antonen; Nina Lahdenpohja; Amos Pasternack; Mikko Hurme
Genetic association between interleukin-10 promoter region polymorphisms and primary Sjögren's syndrome.
Arthritis and rheumatism 2001;44(1):176-9.
2000: T Pessi; Y Sütas; Mikko Hurme; Erika Isolauri
Interleukin-10 generation in atopic children following oral Lactobacillus rhamnosus GG.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2000;30(12):1804-8.
2000: Jukka Peltola; Johanna Palmio; L Korhonen; Jaana Suhonen; A Miettinen; Mikko Hurme; D Lindholm; Tapani Keränen
Interleukin-6 and interleukin-1 receptor antagonist in cerebrospinal fluid from patients with recent tonic-clonic seizures.
Epilepsy research 2000;41(3):205-11.
2000: Jaakko Antonen; Janne Hulkkonen; Amos Pasternack; Mikko Hurme
Interleukin 6 may be an important mediator of trimethoprim-induced systemic adverse reaction resembling aseptic meningitis.
Archives of internal medicine 2000;160(13):2066-7.
2000: Janne Hulkkonen; Pekka Laippala; Mikko Hurme
A rare allele combination of the interleukin-1 gene complex is associated with high interleukin-1 beta plasma levels in healthy individuals.
European cytokine network 2000;11(2):251-5.
2000: Janne Hulkkonen; Juhani Vilpo; Leena Vilpo; Tomi Koski; Mikko Hurme
Interleukin-1 beta, interleukin-1 receptor antagonist and interleukin-6 plasma levels and cytokine gene polymorphisms in chronic lymphocytic leukemia: correlation with prognostic parameters.
Haematologica 2000;85(6):600-6.
1999: Jaakko Antonen; Heikki Saha; Janne Hulkkonen; Jukka Lumio; Amos Pasternack; Mikko Hurme
Increased in vitro production of interleukin 6 in response to trimethoprim among persons with trimethoprim induced systemic adverse reactions.
The Journal of rheumatology 1999;26(12):2585-90.
1999: Merja Helminen; Nina Lahdenpohja; Mikko Hurme
Polymorphism of the interleukin-10 gene is associated with susceptibility to Epstein-Barr virus infection.
The Journal of infectious diseases 1999;180(2):496-9.
1999: Heikki Katila; Kari Hänninen; Mikko Hurme
Polymorphisms of the interleukin-1 gene complex in schizophrenia.
Molecular psychiatry 1999;4(2):179-81.
1999: TO Kerttula; P Collin; Markku Mäki; Mikko Hurme
Normal T-helper 1/T-helper 2 balance in peripheral blood of coeliac disease patients.
Scandinavian journal of immunology 1999;49(2):197-202.
1998: Mikko Hurme; Nina Lahdenpohja; S Santtila
Gene polymorphisms of interleukins 1 and 10 in infectious and autoimmune diseases.
Annals of medicine 1998;30(5):469-73.
1998: Mikko Hurme; Merja Helminen
Polymorphism of the IL-1 gene complex in Epstein-Barr virus seronegative and seropositive adult blood donors.
Scandinavian journal of immunology 1998;48(3):219-22.
1998: Mikko Hurme; S Santtila
IL-1 receptor antagonist (IL-1Ra) plasma levels are co-ordinately regulated by both IL-1Ra and IL-1beta genes.
European journal of immunology 1998;28(8):2598-602.
1998: Jukka Peltola; Mikko Hurme; A Miettinen; Tapani Keränen
Elevated levels of interleukin-6 may occur in cerebrospinal fluid from patients with recent epileptic seizures.
Epilepsy research 1998;31(2):129-33.
1998: Sanna Kilpinen; Mikko Hurme
Low CD3+CD28-induced interleukin-2 production correlates with decreased reactive oxygen intermediate formation in neonatal T cells.
Immunology 1998;94(2):167-72.
1998: Nina Lahdenpohja; Mikko Hurme
CD28-mediated activation in CD45RA+ and CD45RO+ T cells: enhanced levels of reactive oxygen intermediates and c-Rel nuclear translocation in CD45RA+ cells.
Journal of leukocyte biology 1998;63(6):775-80.
1998: S Santtila; Kimmo Savinainen; Mikko Hurme
Presence of the IL-1RA allele 2 (IL1RN*2) is associated with enhanced IL-1beta production in vitro.
Scandinavian journal of immunology 1998;47(3):195-8.
1998: Janne Hulkkonen; Juhani Vilpo; Leena Vilpo; Mikko Hurme
Diminished production of interleukin-6 in chronic lymphocytic leukaemia (B-CLL) cells from patients at advanced stages of disease. Tampere CLL Group.
British journal of haematology 1998;100(3):478-83.
1998: Nina Lahdenpohja; Kimmo Savinainen; Mikko Hurme
Pre-exposure to oxidative stress decreases the nuclear factor-kappa B-dependent transcription in T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(3):1354-8.
1998: Mikko Hurme; Merja Helminen
Resistance to human cytomegalovirus infection may be influenced by genetic polymorphisms of the tumour necrosis factor-alpha and interleukin-1 receptor antagonist genes.
Scandinavian journal of infectious diseases 1998;30(5):447-9.
1997: Markus Halminen; P Klemetti; Outi Vaarala; Mikko Hurme; Jorma Ilonen
Interferon-gamma production in antigen specific T cell response: quantitation of specific mRNA and secreted protein.
Scandinavian journal of immunology 1997;46(4):388-92.
1996: Nina Lahdenpohja; Mikko Hurme
Naive (CD45RA+) T lymphocytes are more sensitive to oxidative stress-induced signals than memory (CD45RO+) cells.
Cellular immunology 1996;173(2):282-6.
1996: S Kilpinen; T Henttinen; Nina Lahdenpohja; Janne Hulkkonen; Mikko Hurme
Signals leading to the activation of NF-kappa B transcription factor are stronger in neonatal than adult T lymphocytes.
Scandinavian journal of immunology 1996;44(1):85-8.
1996: Nina Lahdenpohja; T Henttinen; Mikko Hurme
Activation of the protein kinase A increases the DNA-binding and transcriptional activity of c-Rel in T cells.
Scandinavian journal of immunology 1996;43(6):640-5.
1995: T Henttinen; D E Levy; O Silvennoinen; Mikko Hurme
Activation of the signal transducer and transcription (STAT) signaling pathway in a primary T cell response. Critical role for IL-6.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(10):4582-7.
1994: Mikko Hurme; T Henttinen; M Karppelin; K Varkila; Sampsa Matikainen
Effect of interleukin-10 on NF-kB and AP-1 activities in interleukin-2 dependent CD8 T lymphoblasts.
Immunology letters 1994;42(3):129-33.