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Laurence Hurst

Research Profile

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Publications

TOP 3
Catherine A Charneski; Laurence D Hurst
Positively charged residues are the major determinants of ribosomal velocity.
Tamás Fehér; Gergely Fekete; Laurence D Hurst; Károly Kovács; Orsolya Méhi; Balázs Bogos; Bálint Csörgo; Balázs Papp; György Pósfai; Csaba Pál
Competition between transposable elements and mutator genes in bacteria.
Chunjiang He; Hao Huang; Laurence D Hurst; Zejuan Li; Ping Chen; Jianjun Chen
Young intragenic miRNAs are less coexpressed with host genes than old ones: implications of miRNA-host gene coevolution.

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All Publications

2013: Catherine A Charneski; Laurence D Hurst
Positively charged residues are the major determinants of ribosomal velocity.
PLoS biology 2013;11(3):e1001508.
2012: Tamás Fehér; Gergely Fekete; Laurence D Hurst; Károly Kovács; Orsolya Méhi; Balázs Bogos; Bálint Csörgo; Balázs Papp; György Pósfai; Csaba Pál
Competition between transposable elements and mutator genes in bacteria.
Molecular biology and evolution 2012;29(10):3153-9.
2012: Chunjiang He; Hao Huang; Laurence D Hurst; Zejuan Li; Ping Chen; Jianjun Chen
Young intragenic miRNAs are less coexpressed with host genes than old ones: implications of miRNA-host gene coevolution.
Nucleic acids research 2012;40(9):4002-12.
2012: Claudia C Weber; Catherine J Pink; Laurence D Hurst
Late-replicating domains have higher divergence and diversity in Drosophila melanogaster.
Molecular biology and evolution 2012;29(2):873-82.
2011: Catherine A Charneski; Frank Honti; Laurence D Hurst; Josephine M Bryant; Edward J Feil
Atypical at skew in Firmicute genomes results from selection and not from mutation.
PLoS genetics 2011;7(9):e1002283.
2011: Laurence D Hurst
Molecular genetics: The sound of silence.
Nature 2011;471(7340):582-3.
2011: Alastair S Garfield; Michael Cowley; Florentia M Smith; Kim Moorwood; Joanne E Stewart-Cox; Kerry Gilroy; Sian Baker; Jing Xia; Jeffrey W Dalley; Laurence D Hurst; Lawrence S Wilkinson; Anthony R Isles; Andrew Ward
Distinct physiological and behavioural functions for parental alleles of imprinted Grb10.
Nature 2011;469(7331):534-8.
2011: Catherine J Pink; Laurence D Hurst
Late replicating domains are highly recombining in females but have low male recombination rates: implications for isochore evolution.
PloS one 2011;6(9):e24480.
2011: Claudia C Weber; Laurence D Hurst
Support for multiple classes of local expression clusters in Drosophila melanogaster, but no evidence for gene order conservation.
Genome biology 2011;12(3):R23.
2011: Guang-Zhong Wang; Martin J Lercher; Laurence D Hurst
Transcriptional coupling of neighboring genes and gene expression noise: evidence that gene orientation and noncoding transcripts are modulators of noise.
Genome biology and evolution 2011;3():320-31.
2010: Claudia C Weber; Laurence D Hurst
Intronic AT skew is a defendable proxy for germline transcription but does not predict crossing-over or protein evolution rates in Drosophila melanogaster.
Journal of molecular evolution 2010;71(5-6):415-26.
2010: Laura A McDonald; Dianne Gerrelli; Yvonne Fok; Laurence D Hurst; Cheryll Tickle
Comparison of Iroquois gene expression in limbs/fins of vertebrate embryos.
Journal of anatomy 2010;216(6):683-91.
2010: Tobias Warnecke; Yang Huang; Teresa M Przytycka; Laurence D Hurst
Unique cost dynamics elucidate the role of frameshifting errors in promoting translational robustness.
Genome biology and evolution 2010;2():636-45.
2010: Tobias Warnecke; Laurence D Hurst
GroEL dependency affects codon usage--support for a critical role of misfolding in gene evolution.
Molecular systems biology 2010;6():340.
2010: Marika Charalambous; Michael Cowley; Fleur Geoghegan; Florentia M Smith; Elizabeth J Radford; Benjamin P Marlow; Christopher F Graham; Laurence D Hurst; Andrew Ward
Maternally-inherited Grb10 reduces placental size and efficiency.
Developmental biology 2010;337(1):1-8.
2009: Tobias Warnecke; Claudia C Weber; Laurence D Hurst
Why there is more to protein evolution than protein function: splicing, nucleosomes and dual-coding sequence.
Biochemical Society transactions 2009;37(Pt 4):756-61.
2009: Jean-Vincent Chamary; Laurence D Hurst
The price of silent mutations.
Scientific American 2009;300(6):46-53.
2009: Laurence D Hurst
Fundamental concepts in genetics: genetics and the understanding of selection.
Nature reviews. Genetics 2009;10(2):83-93.
2009: Claudia C Weber; Laurence D Hurst
Protein rates of evolution are predicted by double-strand break events, independent of crossing-over rates.
Genome biology and evolution 2009;1():340-9.
2009: Catherine J Pink; Siva K Swaminathan; Ian Dunham; Jane Rogers; Andrew Ward; Laurence D Hurst
Evidence that replication-associated mutation alone does not explain between-chromosome differences in substitution rates.
Genome biology and evolution 2009;1():13-22.
2009: Tobias Warnecke; Guang-Zhong Wang; Martin J Lercher; Laurence D Hurst
Does negative auto-regulation increase gene duplicability?
BMC evolutionary biology 2009;9():193.
2009: Laurence D Hurst
Evolutionary genomics and the reach of selection.
Journal of biology 2009;8(2):12.
2008: Tobias Warnecke; Nizar N Batada; Laurence D Hurst
The impact of the nucleosome code on protein-coding sequence evolution in yeast.
PLoS genetics 2008;4(11):e1000250.
2008: Susana Lopes; Xueyan Yang; Jeanette Müller; Thomas J Carney; Anthony R McAdow; Gerd-Jörg Rauch; Arie S Jacoby; Laurence D Hurst; Mariana Delfino-Machín; Pascal Haffter; Robert Geisler; Stephen L Johnson; Andrew Ward; Robert Neil Kelsh
Leukocyte tyrosine kinase functions in pigment cell development.
PLoS genetics 2008;4(3):e1000026.
2008: Tobias Warnecke; Joanna L Parmley; Laurence D Hurst
Finding exonic islands in a sea of non-coding sequence: splicing related constraints on protein composition and evolution are common in intron-rich genomes.
Genome biology 2008;9(2):R29.
2008: Araxi Urrutia; Leandro Balladares Ocaña; Laurence D Hurst
Do Alu repeats drive the evolution of the primate transcriptome?
Genome biology 2008;9(2):R25.
2007: Tobias Warnecke; Laurence D Hurst
Evidence for a trade-off between translational efficiency and splicing regulation in determining synonymous codon usage in Drosophila melanogaster.
Molecular biology and evolution 2007;24(12):2755-62.
2007: Nizar N Batada; Araxi Urrutia; Laurence D Hurst
Chromatin remodelling is a major source of coexpression of linked genes in yeast.
Trends in genetics : TIG 2007;23(10):480-4.
2007: Nizar N Batada; Laurence D Hurst
Evolution of chromosome organization driven by selection for reduced gene expression noise.
Nature genetics 2007;39(8):945-9.
2007: Joanna L Parmley; Laurence D Hurst
Exonic splicing regulatory elements skew synonymous codon usage near intron-exon boundaries in mammals.
Molecular biology and evolution 2007;24(8):1600-3.
2007: Nizar N Batada; Teresa Reguly; Ashton Breitkreutz; Lorrie Boucher; Bobby-Joe Breitkreutz; Laurence D Hurst; Mike Tyers
Still stratus not altocumulus: further evidence against the date/party hub distinction.
PLoS biology 2007;5(6):e154.
2007: Joanna L Parmley; Laurence D Hurst
How common are intragene windows with KA > KS owing to purifying selection on synonymous mutations?
Journal of molecular evolution 2007;64(6):646-55.
2007: Joanna L Parmley; Laurence D Hurst
How do synonymous mutations affect fitness?
BioEssays : news and reviews in molecular, cellular and developmental biology 2007;29(6):515-9.
2007: Joanna L Parmley; Araxi Urrutia; Lukasz Potrzebowski; Henrik Kaessmann; Laurence D Hurst
Splicing and the evolution of proteins in mammals.
PLoS biology 2007;5(2):e14.
2006: Nizar N Batada; Teresa Reguly; Ashton Breitkreutz; Lorrie Boucher; Bobby-Joe Breitkreutz; Laurence D Hurst; Mike Tyers
Stratus not altocumulus: a new view of the yeast protein interaction network.
PLoS biology 2006;4(10):e317.
2006: Laurence D Hurst; Edward J Feil; Eduardo P C Rocha
Protein evolution: causes of trends in amino-acid gain and loss.
Nature 2006;442(7105):E11-2; discussion E12.
2006: Laurence D Hurst
Preliminary assessment of the impact of microRNA-mediated regulation on coding sequence evolution in mammals.
Journal of molecular evolution 2006;63(2):174-82.
2006: Nizar N Batada; Laurence D Hurst; Mike Tyers
Evolutionary and physiological importance of hub proteins.
PLoS computational biology 2006;2(7):e88.
2006: Martin J Lercher; Laurence D Hurst
Co-expressed yeast genes cluster over a long range but are not regularly spaced.
Journal of molecular biology 2006;359(3):825-31.
2006: Csaba Pál; Balázs Papp; Martin J Lercher; Péter Csermely; Stephen G Oliver; Laurence D Hurst
Chance and necessity in the evolution of minimal metabolic networks.
Nature 2006;440(7084):667-70.
2006: Jean-Vincent Chamary; Joanna L Parmley; Laurence D Hurst
Hearing silence: non-neutral evolution at synonymous sites in mammals.
Nature reviews. Genetics 2006;7(2):98-108.
2006: Joanna L Parmley; Jean-Vincent Chamary; Laurence D Hurst
Evidence for purifying selection against synonymous mutations in mammalian exonic splicing enhancers.
Molecular biology and evolution 2006;23(2):301-9.
2005: Jean-Vincent Chamary; Laurence D Hurst
Biased codon usage near intron-exon junctions: selection on splicing enhancers, splice-site recognition or something else?
Trends in genetics : TIG 2005;21(5):256-9.
2005: Laurence D Hurst; Martin J Lercher
Unusual linkage patterns of ligands and their cognate receptors indicate a novel reason for non-random gene order in the human genome.
BMC evolutionary biology 2005;5():62.
2005: Laurence D Hurst; Laurent Duret
Bioinformatics with a French accent.
Genome biology 2005;6(10):349.
2005: Jean-Vincent Chamary; Laurence D Hurst
Evidence for selection on synonymous mutations affecting stability of mRNA secondary structure in mammals.
Genome biology 2005;6(9):R75.
2004: Balázs Papp; Csaba Pál; Laurence D Hurst
Metabolic network analysis of the causes and evolution of enzyme dispensability in yeast.
Nature 2004;429(6992):661-4.
2004: Martin J Lercher; Jean-Vincent Chamary; Laurence D Hurst
Genomic regionality in rates of evolution is not explained by clustering of genes of comparable expression profile.
Genome research 2004;14(6):1002-13.
2004: Jean-Vincent Chamary; Laurence D Hurst
Similar rates but different modes of sequence evolution in introns and at exonic silent sites in rodents: evidence for selectively driven codon usage.
Molecular biology and evolution 2004;21(6):1014-23.
2004: Laurence D Hurst; Csaba Pál; Martin J Lercher
The evolutionary dynamics of eukaryotic gene order.
Nature reviews. Genetics 2004;5(4):299-310.
2003: Araxi Urrutia; Laurence D Hurst
The signature of selection mediated by expression on human genes.
Genome research 2003;13(10):2260-4.
2003: Martin J Lercher; Araxi Urrutia; Adam Pavlícek; Laurence D Hurst
A unification of mosaic structures in the human genome.
Human molecular genetics 2003;12(19):2411-5.
2003: Marika Charalambous; Andrew Ward; Laurence D Hurst
Evidence for a priming effect on maternal resource allocation: implications for interbrood competition.
Proceedings. Biological sciences / The Royal Society 2003;270 Suppl 1():S100-3.
2003: Balázs Papp; Csaba Pál; Laurence D Hurst
Evolution of cis-regulatory elements in duplicated genes of yeast.
Trends in genetics : TIG 2003;19(8):417-22.
2003: Balázs Papp; Csaba Pál; Laurence D Hurst
Dosage sensitivity and the evolution of gene families in yeast.
Nature 2003;424(6945):194-7.
2003: Martin J Lercher; Araxi Urrutia; Laurence D Hurst
Evidence that the human X chromosome is enriched for male-specific but not female-specific genes.
Molecular biology and evolution 2003;20(7):1113-6.
2003: Csaba Pál; Laurence D Hurst
Evidence for co-evolution of gene order and recombination rate.
Nature genetics 2003;33(3):392-5.
2003: Martin J Lercher; Thomas Blumenthal; Laurence D Hurst
Coexpression of neighboring genes in Caenorhabditis elegans is mostly due to operons and duplicate genes.
Genome research 2003;13(2):238-43.
2003: Csaba Pál; Balázs Papp; Laurence D Hurst
Genomic function: Rate of evolution and gene dispensability.
Nature 2003;421(6922):496-7; discussion 497-8.
2002: Martin J Lercher; Nick G C Smith; Adam Eyre-Walker; Laurence D Hurst
The evolution of isochores: evidence from SNP frequency distributions.
Genetics 2002;162(4):1805-10.
2002: Laurence D Hurst; Elizabeth J B Williams; Csaba Pál
Natural selection promotes the conservation of linkage of co-expressed genes.
Trends in genetics : TIG 2002;18(12):604-6.
2002: Martin J Lercher; Laurence D Hurst
Can mutation or fixation biases explain the allele frequency distribution of human single nucleotide polymorphisms (SNPs)?
Gene 2002;300(1-2):53-8.
2002: Laurence D Hurst
The Ka/Ks ratio: diagnosing the form of sequence evolution.
Trends in genetics : TIG 2002;18(9):486.
2002: Martin J Lercher; Laurence D Hurst
Human SNP variability and mutation rate are higher in regions of high recombination.
Trends in genetics : TIG 2002;18(7):337-40.
2002: Martin J Lercher; Araxi Urrutia; Laurence D Hurst
Clustering of housekeeping genes provides a unified model of gene order in the human genome.
Nature genetics 2002;31(2):180-3.
2002: Elizabeth J B Williams; Laurence D Hurst
Clustering of tissue-specific genes underlies much of the similarity in rates of protein evolution of linked genes.
Journal of molecular evolution 2002;54(4):511-8.
2002: Laurence D Hurst; James P Randerson
Parasitic sex puppeteers.
Scientific American 2002;286(4):56-61.
2001: Csaba Pál; Balázs Papp; Laurence D Hurst
Does the recombination rate affect the efficiency of purifying selection? The yeast genome provides a partial answer.
Molecular biology and evolution 2001;18(12):2323-6.
2001: Araxi Urrutia; Laurence D Hurst
Codon usage bias covaries with expression breadth and the rate of synonymous evolution in humans, but this is not evidence for selection.
Genetics 2001;159(3):1191-9.
2001: Martin J Lercher; E J Williams; Laurence D Hurst
Local similarity in evolutionary rates extends over whole chromosomes in human-rodent and mouse-rat comparisons: implications for understanding the mechanistic basis of the male mutation bias.
Molecular biology and evolution 2001;18(11):2032-9.
2001: Csaba Pál; Balázs Papp; Laurence D Hurst
Highly expressed genes in yeast evolve slowly.
Genetics 2001;158(2):927-31.
2001: James P Randerson; Laurence D Hurst
A comparative test of a theory for the evolution of anisogamy.
Proceedings. Biological sciences / The Royal Society 2001;268(1469):879-84.
2001: Laurence D Hurst; A R Merchant
High guanine-cytosine content is not an adaptation to high temperature: a comparative analysis amongst prokaryotes.
Proceedings. Biological sciences / The Royal Society 2001;268(1466):493-7.
2001: Laurence D Hurst; Csaba Pál
Evidence for purifying selection acting on silent sites in BRCA1.
Trends in genetics : TIG 2001;17(2):62-5.
2000: Laurence D Hurst; E J Williams
Covariation of GC content and the silent site substitution rate in rodents: implications for methodology and for the evolution of isochores.
Gene 2000;261(1):107-14.
2000: E J Williams; Laurence D Hurst
The proteins of linked genes evolve at similar rates.
Nature 2000;407(6806):900-3.
2000: Laurence D Hurst; James P Randerson
Dosage, deletions and dominance: simple models of the evolution of gene expression.
Journal of theoretical biology 2000;205(4):641-7.
2000: E J Williams; C Pal; Laurence D Hurst
The molecular evolution of signal peptides.
Gene 2000;253(2):313-22.
2000: James P Randerson; Francis M Jiggins; Laurence D Hurst
Male killing can select for male mate choice: a novel solution to the paradox of the lek.
Proceedings. Biological sciences / The Royal Society 2000;267(1446):867-74.
2000: Stephen J Freeland; Robin D Knight; Laura F Landweber; Laurence D Hurst
Early fixation of an optimal genetic code.
Molecular biology and evolution 2000;17(4):511-8.
2000: James P Randerson; Nick G C Smith; Laurence D Hurst
The evolutionary dynamics of male-killers and their hosts.
Heredity 2000;84 ( Pt 2)():152-60.
2000: Laurence D Hurst; Adam Eyre-Walker
Evolutionary genomics: reading the bands.
BioEssays : news and reviews in molecular, cellular and developmental biology 2000;22(2):105-7.
1999: Nick G C Smith; Laurence D Hurst
The effect of tandem substitutions on the correlation between synonymous and nonsynonymous rates in rodents.
Genetics 1999;153(3):1395-402.
1999: Laurence D Hurst; C F Brunton; Nick G C Smith
Small introns tend to occur in GC-rich regions in some but not all vertebrates.
Trends in genetics : TIG 1999;15(11):437-9.
1999: Laurence D Hurst; James P Randerson
An eXceptional chromosome.
Trends in genetics : TIG 1999;15(10):383-5.
1999: Nick G C Smith; R Knight; Laurence D Hurst
Vertebrate genome evolution: a slow shuffle or a big bang?
BioEssays : news and reviews in molecular, cellular and developmental biology 1999;21(8):697-703.
1999: Laurence D Hurst; Nick G C Smith
Do essential genes evolve slowly?
Current biology : CB 1999;9(14):747-50.
1999: Nick G C Smith; Laurence D Hurst
The causes of synonymous rate variation in the rodent genome. Can substitution rates be used to estimate the sex bias in mutation rate?
Genetics 1999;152(2):661-73.
1999: Laurence D Hurst; Nick G C Smith
Molecular evolutionary evidence that H19 mRNA is functional.
Trends in genetics : TIG 1999;15(4):134-5.
1998: Laurence D Hurst; G T McVean
Do we understand the evolution of genomic imprinting?
Current opinion in genetics & development 1998;8(6):701-8.
1998: Laurence D Hurst; H Ellegren
Sex biases in the mutation rate.
Trends in genetics : TIG 1998;14(11):446-52.
1998: Nick G C Smith; Laurence D Hurst
Molecular evolution of an imprinted gene: repeatability of patterns of evolution within the mammalian insulin-like growth factor type II receptor.
Genetics 1998;150(2):823-33.
1997: Laurence D Hurst; G T McVean
Growth effects of uniparental disomies and the conflict theory of genomic imprinting.
Trends in genetics : TIG 1997;13(11):436-43.
1997: G T McVean; Laurence D Hurst
Molecular evolution of imprinted genes: no evidence for antagonistic coevolution.
Proceedings. Biological sciences / The Royal Society 1997;264(1382):739-46.
1997: G T McVean; Laurence D Hurst
Evidence for a selectively favourable reduction in the mutation rate of the X chromosome.
Nature 1997;386(6623):388-92.
1996: G T McVean; Laurence D Hurst; T Moore
Genomic evolution in mice and men: imprinted genes have little intronic content.
BioEssays : news and reviews in molecular, cellular and developmental biology 1996;18(9):773-5.
1996: Laurence D Hurst; G T McVean
Evolutionary genetics...and scandalous symbionts.
Nature 1996;381(6584):650-1.
1996: Laurence D Hurst; G T McVean
A difficult phase for introns-early. Molecular evolution.
Current biology : CB 1996;6(5):533-6.