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Ed Hurt

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Chemicals & Drugs

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Saccharomyces cerevisiae

Anatomy

Physiology

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Vera van Noort; Stefan Amlacher; Manimozhiyan Arumugam; Gert Bange; Bettina Bradatsch; Christopher J Creevey; Sebastian Falk; Ed Hurt; Daniel R Mende; Irmgard Sinning; Peer Bork
Consistent mutational paths predict eukaryotic thermostability.
Thomas Hierlmeier; Ed Hurt; Anja Jacob; Juliane Merl; Philipp Milkereit; Uli Ohmayer; Jorge Perez-Fernandez; Reinhard Rachel; Martina Sauert; Patrick Schultz; Jochen Bassler; Astrid Bruckmann; Rainer Deutzmann; Joachim Griesenbeck; Stephan Hamperl; Kristin Hergert; Herbert Tschochner
Rrp5p, Noc1p and Noc2p form a protein module which is part of early large ribosomal subunit precursors in S. cerevisiae.
Christoph Leidig; Stephan Wickles; Gregor Witte; Stefan Amlacher; Ajay Aravind; Gert Bange; Roland Beckmann; Ed Hurt; Jürgen Kopp; Irmgard Sinning
Structural characterization of a eukaryotic chaperone--the ribosome-associated complex.

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All Publications

2013: Vera van Noort; Stefan Amlacher; Manimozhiyan Arumugam; Gert Bange; Bettina Bradatsch; Christopher J Creevey; Sebastian Falk; Ed Hurt; Daniel R Mende; Irmgard Sinning; Peer Bork
Consistent mutational paths predict eukaryotic thermostability.
BMC evolutionary biology 2013;13():7.
2013: Thomas Hierlmeier; Ed Hurt; Anja Jacob; Juliane Merl; Philipp Milkereit; Uli Ohmayer; Jorge Perez-Fernandez; Reinhard Rachel; Martina Sauert; Patrick Schultz; Jochen Bassler; Astrid Bruckmann; Rainer Deutzmann; Joachim Griesenbeck; Stephan Hamperl; Kristin Hergert; Herbert Tschochner
Rrp5p, Noc1p and Noc2p form a protein module which is part of early large ribosomal subunit precursors in S. cerevisiae.
Nucleic acids research 2013;41(2):1191-210.
2013: Christoph Leidig; Stephan Wickles; Gregor Witte; Stefan Amlacher; Ajay Aravind; Gert Bange; Roland Beckmann; Ed Hurt; Jürgen Kopp; Irmgard Sinning
Structural characterization of a eukaryotic chaperone--the ribosome-associated complex.
Nature structural & molecular biology 2013;20(1):23-8.
2012: Bettina Bradatsch; Marén Gnädig; Sander Granneman; Roland Beckmann; Bettina Böttcher; Christoph Leidig; David Tollervey; Ed Hurt
Structure of the pre-60S ribosomal subunit with nuclear export factor Arx1 bound at the exit tunnel.
Nature structural & molecular biology 2012;19(12):1234-41.
2012: Sébastien Ferreira-Cerca; Ed Hurt; Eileen Chai; Momar Diop; Haiyun Lu; Vatsala Sagar; Thorsten Schäfer; Anne-Maria Wesseling; Nicole A. LaRonde-LeBlanc
ATPase-dependent role of the atypical kinase Rio2 on the evolving pre-40S ribosomal subunit.
Nature structural & molecular biology 2012;19(12):1316-23.
2012: Jochen Bassler; Bettina Bradatsch; Ed Hurt; Martina Kallas; Isabella Klein; Gerald Rechberger; Claudia Schmidt; Heimo Strohmaier; Emma Thomson; Maria Anna Wagner; Helmut Bergler
The conserved Bud20 zinc finger protein is a new component of the ribosomal 60S subunit export machinery.
Molecular and cellular biology 2012;32(24):4898-912.
2012: Dieter Kressler; Yutaka Ogawa; Dagmar Pratte; Irmgard Sinning; Goran Stjepanovic; Daniela Strauss; Yoshihiro Yoneda; Stefan Amlacher; Gert Bange; Bettina Bradatsch; Jun Katahira; Ed Hurt
Synchronizing nuclear import of ribosomal proteins with ribosome assembly.
Science (New York, N.Y.) 2012;338(6107):666-71.
2012: Philipp Stelter; Karsten Thierbach; Matthias Thoms; Emma Thomson; Ruth Kunze; Monika Radwan; Ed Hurt
Monitoring spatiotemporal biogenesis of macromolecular assemblies by pulse-chase epitope labeling.
Molecular cell 2012;47(5):788-96.
2012: Dirk Flemming; Stefan Amlacher; Damien P Devos; Malik Lutzmann; Johannes Schwarz; Ed Hurt
Analysis of the yeast nucleoporin Nup188 reveals a conserved S-like structure with similarity to karyopherins.
Journal of structural biology 2012;177(1):99-105.
2012: Dieter Kressler; Helmut Bergler; Ed Hurt; Jochen Bassler
The power of AAA-ATPases on the road of pre-60S ribosome maturation--molecular machines that strip pre-ribosomal particles.
Biochimica et biophysica acta 2012;1823(1):92-100.
2011: Gert Bange; Przemyslaw Grudnik; Ed Hurt; Dieter Kressler; Nico Kümmerer; Robert Lindner; Georg Petzold; Klemens Wild; Irmgard Sinning
Structural basis for the molecular evolution of SRP-GTPase activation by protein.
Nature structural & molecular biology 2011;18(12):1376-80.
2011: Philipp Stelter; Ruth Kunze; Jessica Fischer; Ed Hurt
Probing the nucleoporin FG repeat network defines structural and functional features of the nuclear pore complex.
The Journal of cell biology 2011;195(2):183-92.
2011: Stefan Amlacher; Manimozhiyan Arumugam; Peer Bork; Damien P Devos; Dirk Flemming; Ruth Kunze; Phillip Sarges; Vera van Noort; Ed Hurt
Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.
Cell 2011;146(2):277-89.
2010: Jochen Bassler; Martina Kallas; Brigitte Pertschy; Cornelia Ulbrich; Matthias Thoms; Ed Hurt
The AAA-ATPase Rea1 drives removal of biogenesis factors during multiple stages of 60S ribosome assembly.
Molecular cell 2010;38(5):712-21.
2010: Dirk Flemming; Karsten Thierbach; Philipp Stelter; Bettina Böttcher; Ed Hurt
Precise mapping of subunits in multiprotein complexes by a versatile electron microscopy label.
Nature structural & molecular biology 2010;17(6):775-8.
2010: Dieter Kressler; Ed Hurt; Jochen Bassler
Driving ribosome assembly.
Biochimica et biophysica acta 2010;1803(6):673-83.
2010: Alwin Köhler; Erik Zimmerman; Maren Schneider; Ed Hurt; Ning Zheng
Structural basis for assembly and activation of the heterotetrameric SAGA histone H2B deubiquitinase module.
Cell 2010;141(4):606-17.
2010: Gunes Bozkurt; Klemens Wild; Stefan Amlacher; Ed Hurt; Bernhard Dobberstein; Irmgard Sinning
The structure of Get4 reveals an alpha-solenoid fold adapted for multiple interactions in tail-anchored protein biogenesis.
FEBS letters 2010;584(8):1509-14.
2010: Alwin Köhler; Ed Hurt
Gene regulation by nucleoporins and links to cancer.
Molecular cell 2010;38(1):6-15.
2009: Gunes Bozkurt; Goran Stjepanovic; Fabio Vilardi; Stefan Amlacher; Klemens Wild; Gert Bange; Vincenzo Favaloro; Karsten Rippe; Ed Hurt; Bernhard Dobberstein; Irmgard Sinning
Structural insights into tail-anchored protein binding and membrane insertion by Get3.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(50):21131-6.
2009: Cornelia Ulbrich; Meikel Diepholz; Jochen Bassler; Dieter Kressler; Brigitte Pertschy; Kyriaki Galani; Bettina Böttcher; Ed Hurt
Mechanochemical removal of ribosome biogenesis factors from nascent 60S ribosomal subunits.
Cell 2009;138(5):911-22.
2009: Dirk Flemming; Phillip Sarges; Philipp Stelter; Andrea Hellwig; Bettina Böttcher; Ed Hurt
Two structurally distinct domains of the nucleoporin Nup170 cooperate to tether a subset of nucleoporins to nuclear pores.
The Journal of cell biology 2009;185(3):387-95.
2009: Christoph Klöckner; Maren Schneider; Sheila Lutz; Divyang Jani; Dieter Kressler; Murray Stewart; Ed Hurt; Alwin Köhler
Mutational uncoupling of the role of Sus1 in nuclear pore complex targeting of an mRNA export complex and histone H2B deubiquitination.
The Journal of biological chemistry 2009;284(18):12049-56.
2009: Thierry Lacombe; Juan J García-Gómez; Jesús de la Cruz; Daniela Roser; Ed Hurt; Patrick Linder; Dieter Kressler
Linear ubiquitin fusion to Rps31 and its subsequent cleavage are required for the efficient production and functional integrity of 40S ribosomal subunits.
Molecular microbiology 2009;72(1):69-84.
2009: Marius Boulos Faza; Stefan Kemmler; Sonia Jimeno; Cristina González-Aguilera; Andrés Aguilera; Ed Hurt; Vikram Govind Panse
Sem1 is a functional component of the nuclear pore complex-associated messenger RNA export machinery.
The Journal of cell biology 2009;184(6):833-46.
2009: Jun Katahira; Hitomi Inoue; Ed Hurt; Yoshihiro Yoneda
Adaptor Aly and co-adaptor Thoc5 function in the Tap-p15-mediated nuclear export of HSP70 mRNA.
The EMBO journal 2009;28(5):556-67.
2009: Michal Skruzný; Claudia Schneider; Attila Rácz; Julan Weng; David Tollervey; Ed Hurt
An endoribonuclease functionally linked to perinuclear mRNP quality control associates with the nuclear pore complexes.
PLoS biology 2009;7(1):e8.
2009: Lindsay S Garrenton; Andreas Braunwarth; Stefan Irniger; Ed Hurt; Markus Künzler; Jeremy Thorner
Nucleus-specific and cell cycle-regulated degradation of mitogen-activated protein kinase scaffold protein Ste5 contributes to the control of signaling competence.
Molecular and cellular biology 2009;29(2):582-601.
2008: Stefanie E Grund; Tamás Fischer; Ghislain G Cabal; Oreto Antúnez; José E Pérez-Ortín; Ed Hurt
The inner nuclear membrane protein Src1 associates with subtelomeric genes and alters their regulated gene expression.
The Journal of cell biology 2008;182(5):897-910.
2008: Rainer Beck; Zhe Sun; Frank Adolf; Chistoph Rutz; Jochen Bassler; Klemens Wild; Irmgard Sinning; Ed Hurt; Britta Brügger; Julien Béthune; Felix T Wieland
Membrane curvature induced by Arf1-GTP is essential for vesicle formation.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(33):11731-6.
2008: Dieter Kressler; Daniela Roser; Brigitte Pertschy; Ed Hurt
The AAA ATPase Rix7 powers progression of ribosome biogenesis by stripping Nsa1 from pre-60S particles.
The Journal of cell biology 2008;181(6):935-44.
2008: Alwin Köhler; Maren Schneider; Ghislain G Cabal; Ulf Nehrbass; Ed Hurt
Yeast Ataxin-7 links histone deubiquitination with gene gating and mRNA export.
Nature cell biology 2008;10(6):707-15.
2008: Nils Schrader; Philipp Stelter; Dirk Flemming; Ruth Kunze; Ed Hurt; Ingrid R Vetter
Structural basis of the nic96 subcomplex organization in the nuclear pore channel.
Molecular cell 2008;29(1):46-55.
2008: Wei Yao; Malik Lutzmann; Ed Hurt
A versatile interaction platform on the Mex67-Mtr2 receptor creates an overlap between mRNA and ribosome export.
The EMBO journal 2008;27(1):6-16.
2007: Alwin Köhler; Ed Hurt
Exporting RNA from the nucleus to the cytoplasm.
Nature reviews. Molecular cell biology 2007;8(10):761-73.
2007: Eva Kowalinski; Gert Bange; Bettina Bradatsch; Ed Hurt; Klemens Wild; Irmgard Sinning
The crystal structure of Ebp1 reveals a methionine aminopeptidase fold as binding platform for multiple interactions.
FEBS letters 2007;581(23):4450-4.
2007: Bettina Bradatsch; Jun Katahira; Eva Kowalinski; Gert Bange; Wei Yao; Toshihiro Sekimoto; Viola Baumgärtel; Guido Boese; Jochen Bassler; Klemens Wild; Reiner Peters; Yoshihiro Yoneda; Irmgard Sinning; Ed Hurt
Arx1 functions as an unorthodox nuclear export receptor for the 60S preribosomal subunit.
Molecular cell 2007;27(5):767-79.
2007: Philipp Stelter; Ruth Kunze; Dirk Flemming; Dominic Höpfner; Meikel Diepholz; Peter Philippsen; Bettina Böttcher; Ed Hurt
Molecular basis for the functional interaction of dynein light chain with the nuclear-pore complex.
Nature cell biology 2007;9(7):788-96.
2007: Vikram Govind Panse; Ed Hurt
Adjunct duties for karyopherins: regulating septin sumoylation.
Developmental cell 2007;12(5):669-70.
2007: Wei Yao; Daniela Roser; Alwin Köhler; Bettina Bradatsch; Jochen Bassler; Ed Hurt
Nuclear export of ribosomal 60S subunits by the general mRNA export receptor Mex67-Mtr2.
Molecular cell 2007;26(1):51-62.
2006: Vikram Govind Panse; Dieter Kressler; Andrea Pauli; Elisabeth Petfalski; Marén Gnädig; David Tollervey; Ed Hurt
Formation and nuclear export of preribosomes are functionally linked to the small-ubiquitin-related modifier pathway.
Traffic (Copenhagen, Denmark) 2006;7(10):1311-21.
2006: Alwin Köhler; Pau Pascual-García; Ana Llopis; Meritxell Zapater; Francesc Posas; Ed Hurt; Susana Rodríguez-Navarro
The mRNA export factor Sus1 is involved in Spt/Ada/Gcn5 acetyltransferase-mediated H2B deubiquitinylation through its interaction with Ubp8 and Sgf11.
Molecular biology of the cell 2006;17(10):4228-36.
2006: Jochen Bassler; Martina Kallas; Ed Hurt
The NUG1 GTPase reveals and N-terminal RNA-binding domain that is essential for association with 60 S pre-ribosomal particles.
The Journal of biological chemistry 2006;281(34):24737-44.
2006: Thorsten Schäfer; Bohumil Maco; Elisabeth Petfalski; David Tollervey; Bettina Böttcher; Ueli Aebi; Ed Hurt
Hrr25-dependent phosphorylation state regulates organization of the pre-40S subunit.
Nature 2006;441(7093):651-5.
2005: Seiji Masuda; Rita Das; Hong Cheng; Ed Hurt; Nijsje Dorman; Robin Reed
Recruitment of the human TREX complex to mRNA during splicing.
Genes & development 2005;19(13):1512-7.
2005: Malik Lutzmann; Ruth Kunze; Karin Stangl; Philipp Stelter; Katalin Fejes Tóth; Bettina Böttcher; Ed Hurt
Reconstitution of Nup157 and Nup145N into the Nup84 complex.
The Journal of biological chemistry 2005;280(18):18442-51.
2005: Kyriaki Galani; Ed Hurt; George Simos
The tRNA aminoacylation co-factor Arc1p is excluded from the nucleus by an Xpo1p-dependent mechanism.
FEBS letters 2005;579(5):969-75.
2004: Kyriaki Galani; tracy nissan; Elisabeth Petfalski; David Tollervey; Ed Hurt
Rea1, a dynein-related nuclear AAA-ATPase, is involved in late rRNA processing and nuclear export of 60 S subunits.
The Journal of biological chemistry 2004;279(53):55411-8.
2004: Vikram Govind Panse; Ulrike Hardeland; Thilo Werner; Bernhard Kuster; Ed Hurt
A proteome-wide approach identifies sumoylated substrate proteins in yeast.
The Journal of biological chemistry 2004;279(40):41346-51.
2004: Tamás Fischer; Susana Rodríguez-Navarro; Gislene Pereira; Attila Rácz; Elmar Schiebel; Ed Hurt
Yeast centrin Cdc31 is linked to the nuclear mRNA export machinery.
Nature cell biology 2004;6(9):840-8.
2004: tracy nissan; Kyriaki Galani; Bohumil Maco; David Tollervey; Ueli Aebi; Ed Hurt
A pre-ribosome with a tadpole-like structure functions in ATP-dependent maturation of 60S subunits.
Molecular cell 2004;15(2):295-301.
2004: Francesca Saracino; Jochen Bassler; Diego Muzzini; Ed Hurt; Maria Luisa Agostoni Carbone
The yeast kinase Swe1 is required for proper entry into cell cycle after arrest due to ribosome biogenesis and protein synthesis defects.
Cell cycle (Georgetown, Tex.) 2004;3(5):648-54.
2004: Ed Hurt; Ming-Juan Luo; Susanne Röther; Robin Reed; Katja Strässer
Cotranscriptional recruitment of the serine-arginine-rich (SR)-like proteins Gbp2 and Hrb1 to nascent mRNA via the TREX complex.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(7):1858-62.
2004: Susana Rodríguez-Navarro; Tamás Fischer; Ming-Juan Luo; Oreto Antúnez; Susanne Brettschneider; Johannes Lechner; José E Pérez-Ortín; Robin Reed; Ed Hurt
Sus1, a functional component of the SAGA histone acetylase complex and the nuclear pore-associated mRNA export machinery.
Cell 2004;116(1):75-86.
2003: Silvia Neumann; Elisabeth Petfalski; Britta Brügger; Helge Grosshans; Felix T Wieland; David Tollervey; Ed Hurt
Formation and nuclear export of tRNA, rRNA and mRNA is regulated by the ubiquitin ligase Rsp5p.
EMBO reports 2003;4(12):1156-62.
2003: Herbert Tschochner; Ed Hurt
Pre-ribosomes on the road from the nucleolus to the cytoplasm.
Trends in cell biology 2003;13(5):255-63.
2003: Andreas Braunwarth; Micheline Fromont-Racine; Pierre Legrain; F Ralf Bischoff; Thomas Gerstberger; Ed Hurt; Markus Kunzler
Identification and characterization of a novel RanGTP-binding protein in the yeast Saccharomyces cerevisiae.
The Journal of biological chemistry 2003;278(17):15397-405.
2003: Thorsten Schäfer; Daniela Strauss; Elisabeth Petfalski; David Tollervey; Ed Hurt
The path from nucleolar 90S to cytoplasmic 40S pre-ribosomes.
The EMBO journal 2003;22(6):1370-80.
2003: Philipp Milkereit; Daniela Strauss; Jochen Bassler; Olivier Gadal; Holger Kühn; Sylvia Schütz; Nicole Gas; Johannes Lechner; Ed Hurt; Herbert Tschochner
A Noc complex specifically involved in the formation and nuclear export of ribosomal 40 S subunits.
The Journal of biological chemistry 2003;278(6):4072-81.
2003: Vikram Govind Panse; Bernhard Küster; Thomas Gerstberger; Ed Hurt
Unconventional tethering of Ulp1 to the transport channel of the nuclear pore complex by karyopherins.
Nature cell biology 2003;5(1):21-7.
2002: Tamás Fischer; Katja Strässer; Attila Rácz; Susana Rodriguez-Navarro; Marisa Oppizzi; Petra Ihrig; Johannes Lechner; Ed Hurt
The mRNA export machinery requires the novel Sac3p-Thp1p complex to dock at the nucleoplasmic entrance of the nuclear pores.
The EMBO journal 2002;21(21):5843-52.
2002: tracy nissan; Jochen Bassler; Elisabeth Petfalski; David Tollervey; Ed Hurt
60S pre-ribosome formation viewed from assembly in the nucleolus until export to the cytoplasm.
The EMBO journal 2002;21(20):5539-47.
2002: Paola Grandi; Vladimir Rybin; Jochen Bassler; Elisabeth Petfalski; Daniela Strauss; Martina Marzioch; Thorsten Schäfer; Bernhard Kuster; Herbert Tschochner; David Tollervey; Anne-Claude Gavin; Ed Hurt
90S pre-ribosomes include the 35S pre-rRNA, the U3 snoRNP, and 40S subunit processing factors but predominantly lack 60S synthesis factors.
Molecular cell 2002;10(1):105-15.
2002: Olivier Gadal; Daniela Strauss; Elisabeth Petfalski; Pierre-Emmanuel Gleizes; Nicole Gas; David Tollervey; Ed Hurt
Rlp7p is associated with 60S preribosomes, restricted to the granular component of the nucleolus, and required for pre-rRNA processing.
The Journal of cell biology 2002;157(6):941-51.
2002: Katja Strässer; Seiji Masuda; Paul Mason; Jens Pfannstiel; Marisa Oppizzi; Susana Rodriguez-Navarro; Ana G Rondón; Andres Aguilera; Kevin Struhl; Robin Reed; Ed Hurt
TREX is a conserved complex coupling transcription with messenger RNA export.
Nature 2002;417(6886):304-8.
2002: Susana Rodríguez-Navarro; Katja Strässer; Ed Hurt
An intron in the YRA1 gene is required to control Yra1 protein expression and mRNA export in yeast.
EMBO reports 2002;3(5):438-42.
2002: Jun Katahira; Katja Straesser; Takuya Saiwaki; Yoshihiro Yoneda; Ed Hurt
Complex formation between Tap and p15 affects binding to FG-repeat nucleoporins and nucleocytoplasmic shuttling.
The Journal of biological chemistry 2002;277(11):9242-6.
2002: Robin Reed; Ed Hurt
A conserved mRNA export machinery coupled to pre-mRNA splicing.
Cell 2002;108(4):523-31.
2002: Malik Lutzmann; Ruth Kunze; Andrea Buerer; Ueli Aebi; Ed Hurt
Modular self-assembly of a Y-shaped multiprotein complex from seven nucleoporins.
The EMBO journal 2002;21(3):387-97.
2002: George Simos; Helge Grosshans; Ed Hurt
Nuclear export of tRNA.
Results and problems in cell differentiation 2002;35():115-31.
2001: Helge Grosshans; François Lecointe; Henri Grosjean; Ed Hurt; George Simos
Pus1p-dependent tRNA pseudouridinylation becomes essential when tRNA biogenesis is compromised in yeast.
The Journal of biological chemistry 2001;276(49):46333-9.
2001: Bruno Senger; D L Lafontaine; Jean-Sébastien Graindorge; Olivier Gadal; A Camasses; A Sanni; J M Garnier; Michael Breitenbach; Ed Hurt; Franco Fasiolo
The nucle(ol)ar Tif6p and Efl1p are required for a late cytoplasmic step of ribosome synthesis.
Molecular cell 2001;8(6):1363-73.
2001: SM Bailer; C Balduf; Ed Hurt
The Nsp1p carboxy-terminal domain is organized into functionally distinct coiled-coil regions required for assembly of nucleoporin subcomplexes and nucleocytoplasmic transport.
Molecular and cellular biology 2001;21(23):7944-55.
2001: Katja Strässer; Ed Hurt
Splicing factor Sub2p is required for nuclear mRNA export through its interaction with Yra1p.
Nature 2001;413(6856):648-52.
2001: Markus Künzler; Ed Hurt
Targeting of Ran: variation on a common theme?
Journal of cell science 2001;114(Pt 18):3233-41.
2001: Jochen Bassler; Paola Grandi; Olivier Gadal; T Lessmann; Elisabeth Petfalski; David Tollervey; Johannes Lechner; Ed Hurt
Identification of a 60S preribosomal particle that is closely linked to nuclear export.
Molecular cell 2001;8(3):517-29.
2001: Olivier Gadal; Daniela Strauss; J Braspenning; Dominic Hoepfner; Elisabeth Petfalski; Peter Philippsen; David Tollervey; Ed Hurt
A nuclear AAA-type ATPase (Rix7p) is required for biogenesis and nuclear export of 60S ribosomal subunits.
The EMBO journal 2001;20(14):3695-704.
2001: Philipp Milkereit; Olivier Gadal; Alexandre Podtelejnikov; S Trumtel; Nicole Gas; Elisabeth Petfalski; David Tollervey; Matthias Mann; Ed Hurt; Herbert Tschochner
Maturation and intranuclear transport of pre-ribosomes requires Noc proteins.
Cell 2001;105(4):499-509.
2001: Helge Grosshans; K Deinert; Ed Hurt; George Simos
Biogenesis of the signal recognition particle (SRP) involves import of SRP proteins into the nucleolus, assembly with the SRP-RNA, and Xpo1p-mediated export.
The Journal of cell biology 2001;153(4):745-62.
2001: Olivier Gadal; Daniela Strauss; J Kessl; Bernard L Trumpower; David Tollervey; Ed Hurt
Nuclear export of 60s ribosomal subunits depends on Xpo1p and requires a nuclear export sequence-containing factor, Nmd3p, that associates with the large subunit protein Rpl10p.
Molecular and cellular biology 2001;21(10):3405-15.
2001: Markus Künzler; J Trueheart; C Sette; Ed Hurt; Jeremy Thorner
Mutations in the YRB1 gene encoding yeast ran-binding-protein-1 that impair nucleocytoplasmic transport and suppress yeast mating defects.
Genetics 2001;157(3):1089-105.
2000: K Hellmuth; Henri Grosjean; Yuri Motorin; K Deinert; Ed Hurt; George Simos
Cloning and characterization of the Schizosaccharomyces pombe tRNA:pseudouridine synthase Pus1p.
Nucleic acids research 2000;28(23):4604-10.
2000: Natalia Gomez-Ospina; G Morgan; Thomas H Giddings; B Kosova; Ed Hurt; Mark Winey
Yeast nuclear pore complex assembly defects determined by nuclear envelope reconstruction.
Journal of structural biology 2000;132(1):1-5.
2000: Z Zhou; Ming-Juan Luo; K Straesser; Jun Katahira; Ed Hurt; Robin Reed
The protein Aly links pre-messenger-RNA splicing to nuclear export in metazoans.
Nature 2000;407(6802):401-5.
2000: Katja Strässer; Jochen Bassler; Ed Hurt
Binding of the Mex67p/Mtr2p heterodimer to FXFG, GLFG, and FG repeat nucleoporins is essential for nuclear mRNA export.
The Journal of cell biology 2000;150(4):695-706.
2000: SM Bailer; C Balduf; Jun Katahira; Alexandre Podtelejnikov; Christiane Rollenhagen; Matthias Mann; N Pante; Ed Hurt
Nup116p associates with the Nup82p-Nsp1p-Nup159p nucleoporin complex.
The Journal of biological chemistry 2000;275(31):23540-8.
2000: Markus Künzler; Thomas Gerstberger; F Stutz; F Ralf Bischoff; Ed Hurt
Yeast Ran-binding protein 1 (Yrb1) shuttles between the nucleus and cytoplasm and is exported from the nucleus via a CRM1 (XPO1)-dependent pathway.
Molecular and cellular biology 2000;20(12):4295-308.
2000: Symeon Siniossoglou; Malik Lutzmann; Helena Santos-Rosa; K Leonard; S Mueller; U Aebi; Ed Hurt
Structure and assembly of the Nup84p complex.
The Journal of cell biology 2000;149(1):41-54.
2000: Helge Grosshans; George Simos; Ed Hurt
Review: transport of tRNA out of the nucleus-direct channeling to the ribosome?
Journal of structural biology 2000;129(2-3):288-94.
2000: Helge Grosshans; Ed Hurt; George Simos
An aminoacylation-dependent nuclear tRNA export pathway in yeast.
Genes & development 2000;14(7):830-40.
2000: Ed Hurt; Katja Strässer; A Segref; SM Bailer; N Schlaich; C Presutti; D Tollervey; R Jansen
Mex67p mediates nuclear export of a variety of RNA polymerase II transcripts.
The Journal of biological chemistry 2000;275(12):8361-8.
2000: Katja Strässer; Ed Hurt
Yra1p, a conserved nuclear RNA-binding protein, interacts directly with Mex67p and is required for mRNA export.
The EMBO journal 2000;19(3):410-20.
2000: D Lau; Markus Künzler; A Braunwarth; K Hellmuth; Alexandre Podtelejnikov; Matthias Mann; Ed Hurt
Purification of protein A-tagged yeast ran reveals association with a novel karyopherin beta family member, Pdr6p.
The Journal of biological chemistry 2000;275(1):467-71.
2000: B Kosova; Nelly Panté; Christiane Rollenhagen; Alexandre Podtelejnikov; Matthias Mann; Ueli Aebi; Ed Hurt
Mlp2p, a component of nuclear pore attached intranuclear filaments, associates with nic96p.
The Journal of biological chemistry 2000;275(1):343-50.
1999: B Kosova; Nelly Panté; Christiane Rollenhagen; Ed Hurt
Nup192p is a conserved nucleoporin with a preferential location at the inner site of the nuclear membrane.
The Journal of biological chemistry 1999;274(32):22646-51.
1999: Katja Strässer; Ed Hurt
Nuclear RNA export in yeast.
FEBS letters 1999;452(1-2):77-81.
1999: Jun Katahira; Katja Strässer; Alexandre Podtelejnikov; Matthias Mann; Jae U. Jung; Ed Hurt
The Mex67p-mediated nuclear mRNA export pathway is conserved from yeast to human.
The EMBO journal 1999;18(9):2593-609.
1999: George Simos; Ed Hurt
Transfer RNA biogenesis: A visa to leave the nucleus.
Current biology : CB 1999;9(7):R238-41.
1999: Ed Hurt; S Hannus; B Schmelzl; D Lau; David Tollervey; George Simos
A novel in vivo assay reveals inhibition of ribosomal nuclear export in ran-cycle and nucleoporin mutants.
The Journal of cell biology 1999;144(3):389-401.
1998: Symeon Siniossoglou; Helena Santos-Rosa; Juri Rappsilber; Matthias Mann; Ed Hurt
A novel complex of membrane proteins required for formation of a spherical nucleus.
The EMBO journal 1998;17(22):6449-64.
1998: Helena Santos-Rosa; H Moreno; George Simos; A Segref; Birthe Fahrenkrog; Nelly Panté; Ed Hurt
Nuclear mRNA export requires complex formation between Mex67p and Mtr2p at the nuclear pores.
Molecular and cellular biology 1998;18(11):6826-38.
1998: K Hellmuth; D M Lau; F Ralf Bischoff; Markus Künzler; Ed Hurt; George Simos
Yeast Los1p has properties of an exportin-like nucleocytoplasmic transport factor for tRNA.
Molecular and cellular biology 1998;18(11):6374-86.
1998: Yuri Motorin; Gérard Keith; C Simon; D Foiret; George Simos; Ed Hurt; Henri Grosjean
The yeast tRNA:pseudouridine synthase Pus1p displays a multisite substrate specificity.
RNA (New York, N.Y.) 1998;4(7):856-69.
1998: Bruno Senger; George Simos; F Ralf Bischoff; Alexandre Podtelejnikov; M Mann; Ed Hurt
Mtr10p functions as a nuclear import receptor for the mRNA-binding protein Npl3p.
The EMBO journal 1998;17(8):2196-207.
1998: SM Bailer; Symeon Siniossoglou; Alexandre Podtelejnikov; Andrea Hellwig; Matthias Mann; Ed Hurt
Nup116p and nup100p are interchangeable through a conserved motif which constitutes a docking site for the mRNA transport factor gle2p.
The EMBO journal 1998;17(4):1107-19.
1997: Paola Grandi; T Dang; N Pané; A Shevchenko; Matthias Mann; D Forbes; Ed Hurt
Nup93, a vertebrate homologue of yeast Nic96p, forms a complex with a novel 205-kDa protein and is required for correct nuclear pore assembly.
Molecular biology of the cell 1997;8(10):2017-38.
1997: Maria Teresa Teixeira; Symeon Siniossoglou; S Podtelejnikov; J C Bénichou; Matthias Mann; Bernard Dujon; Ed Hurt; Emmanuelle FABRE
Two functionally distinct domains generated by in vivo cleavage of Nup145p: a novel biogenesis pathway for nucleoporins.
The EMBO journal 1997;16(16):5086-97.
1997: A Segref; K Sharma; Valérie Doye; Andrea Hellwig; J Huber; R Lührmann; Ed Hurt
Mex67p, a novel factor for nuclear mRNA export, binds to both poly(A)+ RNA and nuclear pores.
The EMBO journal 1997;16(11):3256-71.
1997: Valérie Doye; Ed Hurt
From nucleoporins to nuclear pore complexes.
Current opinion in cell biology 1997;9(3):401-11.
1997: Emmanuelle FABRE; Ed Hurt
Yeast genetics to dissect the nuclear pore complex and nucleocytoplasmic trafficking.
Annual review of genetics 1997;31():277-313.