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Syed Husain

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Joseph Bekisz; Syed R Husain; Chase Johnson; Raj K Puri; Yuki Sato; Kathy Zoon
Immunomodulatory effects of interferons in malignancies.
Hideyuki Nakashima; Raj K Puri; Samuel Baron; Joseph Bekisz; Christopher R Clark; Joel Finbloom; Syed R Husain; Kotaro Miyake; Kathy Zoon
Potent antitumor effects of combination therapy with IFNs and monocytes in mouse models of established human ovarian and melanoma tumors.
Wu Ou; Raj K Puri; Akiko Suzuki; Evanthia Galanis; Syed R Husain; Bharat Joshi; Andrea Maisner; Michael P Marino; Jakob Reiser
Specific targeting of human interleukin (IL)-13 receptor α2-positive cells with lentiviral vectors displaying IL-13.

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2013: Joseph Bekisz; Syed R Husain; Chase Johnson; Raj K Puri; Yuki Sato; Kathy Zoon
Immunomodulatory effects of interferons in malignancies.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2013;33(4):154-61.
2012: Hideyuki Nakashima; Raj K Puri; Samuel Baron; Joseph Bekisz; Christopher R Clark; Joel Finbloom; Syed R Husain; Kotaro Miyake; Kathy Zoon
Potent antitumor effects of combination therapy with IFNs and monocytes in mouse models of established human ovarian and melanoma tumors.
Cancer immunology, immunotherapy : CII 2012;61(7):1081-92.
2012: Wu Ou; Raj K Puri; Akiko Suzuki; Evanthia Galanis; Syed R Husain; Bharat Joshi; Andrea Maisner; Michael P Marino; Jakob Reiser
Specific targeting of human interleukin (IL)-13 receptor α2-positive cells with lentiviral vectors displaying IL-13.
Human gene therapy methods 2012;23(2):137-47.
2011: Hideyuki Nakashima; Jay A Berzofsky; Syed R Husain; Masaki Terabe; Raj K Puri
A novel combination immunotherapy for cancer by IL-13Rα2-targeted DNA vaccine and immunotoxin in murine tumor models.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(10):4935-46.
2010: Sandeep Kunwar; Susan Chang; Manfred Westphal; Michael A Vogelbaum; John Sampson; Gene Barnett; Mark Shaffrey; Zvi Ram; Joseph M Piepmeier; Michael Prados; David Croteau; Christoph Pedain; Pamela Leland; Syed R Husain; Bharat H Joshi; Raj K Puri
Phase III randomized trial of CED of IL13-PE38QQR vs Gliadel wafers for recurrent glioblastoma.
Neuro-oncology 2010;12(8):871-81.
2010: Takeshi Shimamura; Toshio Fujisawa; Syed R Husain; Bharat Joshi; Raj K Puri
Interleukin 13 mediates signal transduction through interleukin 13 receptor alpha2 in pancreatic ductal adenocarcinoma: role of IL-13 Pseudomonas exotoxin in pancreatic cancer therapy.
Clinical cancer research : an official journal of the American Association for Cancer Research 2010;16(2):577-86.
2010: Hideyuki Nakashima; Toshio Fujisawa; Syed R Husain; Raj K Puri
Interleukin-13 receptor α2 DNA prime boost vaccine induces tumor immunity in murine tumor models.
Journal of translational medicine 2010;8():116.
2009: Mitomu Kioi; Takeshi Shimamura; Hideyuki Nakashima; Makoto Hirota; Iwai Tohnai; Syed R Husain; Raj K Puri
IL-13 cytotoxin has potent antitumor activity and synergizes with paclitaxel in a mouse model of oral squamous cell carcinoma.
International journal of cancer. Journal international du cancer 2009;124(6):1440-8.
2008: Takeshi Shimamura; Toshio Fujisawa; Syed R Husain; Mitomu Kioi; Atsushi Nakajima; Raj K Puri
Novel role of IL-13 in fibrosis induced by nonalcoholic steatohepatitis and its amelioration by IL-13R-directed cytotoxin in a rat model.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(7):4656-65.
2007: Takeshi Shimamura; Richard E Royal; Mitomu Kioi; Atsushi Nakajima; Syed R Husain; Raj K Puri
Interleukin-4 cytotoxin therapy synergizes with gemcitabine in a mouse model of pancreatic ductal adenocarcinoma.
Cancer research 2007;67(20):9903-12.
2006: Mitomu Kioi; Mariko Kawakami; Takeshi Shimamura; Syed R Husain; Raj K Puri
Interleukin-13 receptor alpha2 chain: a potential biomarker and molecular target for ovarian cancer therapy.
Cancer 2006;107(6):1407-18.
2006: Mitomu Kioi; Syed R Husain; David Croteau; Sandeep Kunwar; Raj K Puri
Convection-enhanced delivery of interleukin-13 receptor-directed cytotoxin for malignant glioma therapy.
Technology in cancer research & treatment 2006;5(3):239-50.
2006: Bharat H Joshi; Cory M Hogaboam; Pamela Dover; Syed R Husain; Raj K Puri
Role of interleukin-13 in cancer, pulmonary fibrosis, and other T(H)2-type diseases.
Vitamins and hormones 2006;74():479-504.
2006: Sandeep Kunwar; Susan M Chang; Michael D Prados; Mitchel S Berger; John H Sampson; David Croteau; Jeffrey W Sherman; Amy Y Grahn; Vince S Shu; Jeanne L Dul; Syed R Husain; Bharat H Joshi; Christoph Pedain; Raj K Puri
Safety of intraparenchymal convection-enhanced delivery of cintredekin besudotox in early-phase studies.
Neurosurgical focus 2006;20(4):E15.
2006: Takeshi Shimamura; Syed R Husain; Raj K Puri
The IL-4 and IL-13 pseudomonas exotoxins: new hope for brain tumor therapy.
Neurosurgical focus 2006;20(4):E11.
2004: Koji Kawakami; Mariko Kawakami; Mitomu Kioi; Syed R Husain; Raj K Puri
Distribution kinetics of targeted cytotoxin in glioma by bolus or convection-enhanced delivery in a murine model.
Journal of neurosurgery 2004;101(6):1004-11.
2004: Bryce D Beseth; Robert B Cameron; Pamela Leland; Liang You; Frederick Varricchio; Robert J Kreitman; Richard A Maki; David M Jablons; Syed R Husain; Raj K Puri
Interleukin-4 receptor cytotoxin as therapy for human malignant pleural mesothelioma xenografts.
The Annals of thoracic surgery 2004;78(2):436-43; discussion 436-43.
2003: Mariska C de Jong; George L Scheffer; Henk J Broxterman; Jan Hendrik Hooijberg; Jerry W Slootstra; Rob H Meloen; Robert J Kreitman; Syed R Husain; Bharat H Joshi; Raj K Puri; Rik J Scheper
Multidrug-resistant tumor cells remain sensitive to a recombinant interleukin-4-Pseudomonas exotoxin, except when overexpressing the multidrug resistance protein MRP1.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(13):5009-17.
2003: Syed R Husain; Raj K Puri
Interleukin-13 receptor-directed cytotoxin for malignant glioma therapy: from bench to bedside.
Journal of neuro-oncology 2003;65(1):37-48.
2003: Koji Kawakami; Mariko Kawakami; Syed R Husain; Raj K Puri
Potent antitumor activity of IL-13 cytotoxin in human pancreatic tumors engineered to express IL-13 receptor alpha2 chain in vivo.
Gene therapy 2003;10(13):1116-28.
2003: Koji Kawakami; Mariko Kawakami; Syed R Husain; Raj K Puri
Effect of interleukin (IL)-4 cytotoxin on breast tumor growth after in vivo gene transfer of IL-4 receptor alpha chain.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(5):1826-36.
2003: Syed R Husain; Koji Kawakami; Mariko Kawakami; Raj K Puri
Interleukin-4 receptor-targeted cytotoxin therapy of androgen-dependent and -independent prostate carcinoma in xenograft models.
Molecular cancer therapeutics 2003;2(3):245-54.
2002: Mariko Kawakami; Koji Kawakami; Vitaly A Stepensky; Richard A Maki; Howard Robin; Wayne Muller; Syed R Husain; Raj K Puri
Interleukin 4 receptor on human lung cancer: a molecular target for cytotoxin therapy.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(11):3503-11.
2002: Koji Kawakami; Syed R Husain; Mariko Kawakami; Raj K Puri
Improved anti-tumor activity and safety of interleukin-13 receptor targeted cytotoxin by systemic continuous administration in head and neck cancer xenograft model.
Molecular medicine (Cambridge, Mass.) 2002;8(8):487-94.
2002: Koji Kawakami; Mariko Kawakami; Syed R Husain; Raj K Puri
Targeting interleukin-4 receptors for effective pancreatic cancer therapy.
Cancer research 2002;62(13):3575-80.
2001: Koji Kawakami; Mariko Kawakami; Philip Snoy; Syed R Husain; Raj K Puri
In vivo overexpression of IL-13 receptor alpha2 chain inhibits tumorigenicity of human breast and pancreatic tumors in immunodeficient mice.
The Journal of experimental medicine 2001;194(12):1743-54.
2001: Koji Kawakami; Syed R Husain; R K Bright; Raj K Puri
Gene transfer of interleukin 13 receptor alpha2 chain dramatically enhances the antitumor effect of IL-13 receptor-targeted cytotoxin in human prostate cancer xenografts.
Cancer gene therapy 2001;8(11):861-8.
2001: Syed R Husain; Bharat H Joshi; Raj K Puri
Interleukin-13 receptor as a unique target for anti-glioblastoma therapy.
International journal of cancer. Journal international du cancer 2001;92(2):168-75.
2000: Bharat H Joshi; Syed R Husain; Raj K Puri
Preclinical studies with IL-13PE38QQR for therapy of malignant glioma.
Drug news & perspectives 2000;13(10):599-605.
2000: Syed R Husain; Raj K Puri
Interleukin-13 fusion cytotoxin as a potent targeted agent for AIDS-Kaposi's sarcoma xenograft.
Blood 2000;95(11):3506-13.
2000: Pamela Leland; J Taguchi; Syed R Husain; Robert J Kreitman; Ira Pastan; Raj K Puri
Human breast carcinoma cells express type II IL-4 receptors and are sensitive to antitumor activity of a chimeric IL-4-Pseudomonas exotoxin fusion protein in vitro and in vivo.
Molecular medicine (Cambridge, Mass.) 2000;6(3):165-78.
1999: Syed R Husain; Robert J Kreitman; Ira Pastan; Raj K Puri
Interleukin-4 receptor-directed cytotoxin therapy of AIDS-associated Kaposi's sarcoma tumors in xenograft model.
Nature medicine 1999;5(7):817-22.
1998: Syed R Husain; N Behari; Robert J Kreitman; Ira Pastan; Raj K Puri
Complete regression of established human glioblastoma tumor xenograft by interleukin-4 toxin therapy.
Cancer research 1998;58(16):3649-53.
1998: T Murata; Syed R Husain; H Mohri; Raj K Puri
Two different IL-13 receptor chains are expressed in normal human skin fibroblasts, and IL-4 and IL-13 mediate signal transduction through a common pathway.
International immunology 1998;10(8):1103-10.
1998: R Mehrotra; Frederick Varricchio; Syed R Husain; Raj K Puri
Head and neck cancers, but not benign lesions, express interleukin-4 receptors in situ.
Oncology reports 1998;5(1):45-8.
1997: Syed R Husain; P Gill; Robert J Kreitman; Ira Pastan; Raj K Puri
Interleukin-4 receptor expression on AIDS-associated Kaposi's sarcoma cells and their targeting by a chimeric protein comprised of circularly permuted interleukin-4 and Pseudomonas exotoxin.
Molecular medicine (Cambridge, Mass.) 1997;3(5):327-38.
1997: Syed R Husain; NI Obiri; P Gill; T Zheng; Ira Pastan; Waldemar Debinski; Raj K Puri
Receptor for interleukin 13 on AIDS-associated Kaposi's sarcoma cells serves as a new target for a potent Pseudomonas exotoxin-based chimeric toxin protein.
Clinical cancer research : an official journal of the American Association for Cancer Research 1997;3(2):151-6.
1997: Frederick Varricchio; Syed R Husain; Pamela Leland; P Gill; Raj K Puri
Interleukin-4 receptor expression in vivo on human AIDS-related Kaposi's sarcoma.
Oncology research 1997;9(9):495-503.
1996: NI Obiri; Syed R Husain; Waldemar Debinski; Raj K Puri
Interleukin 13 inhibits growth of human renal cell carcinoma cells independently of the p140 interleukin 4 receptor chain.
Clinical cancer research : an official journal of the American Association for Cancer Research 1996;2(10):1743-9.
1996: Syed R Husain; Pamela Leland; B B Aggarwal; Raj K Puri
Transcriptional up-regulation of interleukin 4 receptors by human immunodeficiency virus type 1 tat gene.
AIDS research and human retroviruses 1996;12(14):1349-59.
1996: Raj K Puri; Pamela Leland; NI Obiri; Syed R Husain; J Mule; Ira Pastan; Robert J Kreitman
An improved circularly permuted interleukin 4-toxin is highly cytotoxic to human renal cell carcinoma cells. Introduction of gamma c chain in RCC cells does not improve sensitivity.
Cellular immunology 1996;171(1):80-6.
1996: Raj K Puri; Pamela Leland; NI Obiri; Syed R Husain; Robert J Kreitman; Gabriel P Haas; Ira Pastan; Waldemar Debinski
Targeting of interleukin-13 receptor on human renal cell carcinoma cells by a recombinant chimeric protein composed of interleukin-13 and a truncated form of Pseudomonas exotoxin A (PE38QQR).
Blood 1996;87(10):4333-9.