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David Huso

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I Rybanska; J Bakhsheshian; J Chou; David L Huso; O Ishaq; M Prakash; Sonia Franco
PARP1 and DNA-PKcs synergize to suppress p53 mutation and telomere fusions during T-lineage lymphomagenesis.
Sandeep N Shah; Saraswati Sukumar; C Conover Talbot; Sujayita Roy; Amy Belton; Leslie Cope; David L Huso; Weijie Poh; Linda M. Resar
HMGA1: A Master Regulator of Tumor Progression in Triple-Negative Breast Cancer Cells.
Baktiar O Karim; Guosheng Liu; Ki-Jong Rhee; Dongfeng Zheng; David L Huso
Chemoprevention utility of silibinin and Cdk4 pathway inhibition in Apc(-/+) mice.

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All Publications

2013: I Rybanska; J Bakhsheshian; J Chou; David L Huso; O Ishaq; M Prakash; Sonia Franco
PARP1 and DNA-PKcs synergize to suppress p53 mutation and telomere fusions during T-lineage lymphomagenesis.
Oncogene 2013;32(14):1761-71.
2013: Sandeep N Shah; Saraswati Sukumar; C Conover Talbot; Sujayita Roy; Amy Belton; Leslie Cope; David L Huso; Weijie Poh; Linda M. Resar
HMGA1: A Master Regulator of Tumor Progression in Triple-Negative Breast Cancer Cells.
PloS one 2013;8(5):e63419.
2013: Baktiar O Karim; Guosheng Liu; Ki-Jong Rhee; Dongfeng Zheng; David L Huso
Chemoprevention utility of silibinin and Cdk4 pathway inhibition in Apc(-/+) mice.
BMC cancer 2013;13():157.
2012: Yong Soon Chun; Roeland F de Wilde; Seung-Mo Hong; David L Huso; Anirban Maitra; Dipankar Pramanik; Michelle A Rudek; Vered Stearns; Savita Bisht; Venugopal Chenna; Takahiro Yoshida; Zhe Zhang; Ming Zhao; Saraswati Sukumar
Intraductal administration of a polymeric nanoparticle formulation of curcumin (NanoCurc) significantly attenuates incidence of mammary tumors in a rodent chemical carcinogenesis model: Implications for breast cancer chemoprevention in at-risk populations.
Carcinogenesis 2012;33(11):2242-9.
2012: Amy J Naylor; Caroline Ospelt; Callum Poyser; Michael J Rogers; Stuart Smith; Mark S Cooper; Adam Croft; Jeremy S Duffield; Steffen Gay; Simon R Goodyear; David L Huso; Clare Isacke; Eman Azzam; Christopher D Buckley
The mesenchymal stem cell marker CD248 (endosialin) is a negative regulator of bone formation in mice.
Arthritis and rheumatism 2012;64(10):3334-43.
2012: S Haihua Chu; Curt I Civin; Michael I Collector; Diane Heiser; David L Huso; Ian Kaplan; Li Li; Saul J Sharkis; Donald Small
FLT3-ITD knockin impairs hematopoietic stem cell quiescence/homeostasis, leading to myeloproliferative neoplasm.
Cell stem cell 2012;11(3):346-58.
2012: Nicole Simonavicius; Antoinette van Weverwijk; Helen Yarwood; Ivo J Huijbers; Matthew Ashenden; Christopher D Buckley; Ivo J Huijber; David L Huso; Siân Lax; Clare M Isacke
Pericytes promote selective vessel regression to regulate vascular patterning.
Blood 2012;120(7):1516-27.
2012: Yong Soon Chun; David L Huso; Richard J Jones; Tsuyoshi Mori; Brandy Perkins; Vered Stearns; Takahiro Yoshida; Zhe Zhang; Saraswati Sukumar
Intraductally administered pegylated liposomal doxorubicin reduces mammary stem cell function in the mammary gland but in the long term, induces malignant tumors.
Breast cancer research and treatment 2012;135(1):201-8.
2012: Robert F Hobbs; David L Huso; Hong Song; Margaret H Sundel; George Sgouros
A nephron-based model of the kidneys for macro-to-micro α-particle dosimetry.
Physics in medicine and biology 2012;57(13):4403-24.
2012: Joelle Anne Hillion; David L Huso; Tait Huso; Collins Karikari; Anirban Maitra; Dwella Moton Nelson; Abimbola Aderinto; Amy Belton; Nathaniel Campbell; Leslie Cope; Francescopaolo Di Cello; Andrew Schuldenfrei; Sandeep N Shah; Shamayra S Smail; Linda M. Resar
The HMGA1-COX-2 axis: a key molecular pathway and potential target in pancreatic adenocarcinoma.
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2012;12(4):372-9.
2012: Yingli Wang; Xueyan Zhou; Ross Couwenhoven; Jenna Friedenthal; Greg Holmes; David L Huso; Pavel Krejci; Kurun Oberoi; Christopher J Percival; Robert Phelps; Michael Rendl; Amélie Rezza; Joan T Richtsmeier; Miao Sun; Ethylin Jabs
p38 Inhibition ameliorates skin and skull abnormalities in Fgfr2 Beare-Stevenson mice.
The Journal of clinical investigation 2012;122(6):2153-64.
2012: Matthew R Dallas; David L Huso; Guosheng Liu; Susan N Thomas; Denis Wirtz; Wei-Chiang Chen; Konstantinos Konstantopoulos
Divergent roles of CD44 and carcinoembryonic antigen in colon cancer metastasis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012;26(6):2648-56.
2012: Yulan Cheng; Gilbert M Green; David L Huso; RONNIE MEASE; Meltzer Stephen J.; Martin G Pomper; Srinivasan Senthamizhchelvan; George Sgouros; Rachana Agarwal; John M Abraham
[32P]ATP inhibits the growth of xenografted tumors in nude mice.
Cell cycle (Georgetown, Tex.) 2012;11(10):1878-82.
2012: Sarah Greenblatt; David L Huso; Li Li; Bao Nguyen; Rachel Novak; Christopher Slape; Peter D Aplan; Michael J Borowitz; Stephen Desiderio; Amy Duffield; Donald Small
Knock-in of a FLT3/ITD mutation cooperates with a NUP98-HOXD13 fusion to generate acute myeloid leukemia in a mouse model.
Blood 2012;119(12):2883-94.
2012: Siân Lax; Jennifer L Marshall; Ewan A Ross; Andrea White; Adam F Cunningham; David L Huso; Clare M Isacke; William E Jenkinson; Graham Anderson; Christopher D Buckley
CD248 expression on mesenchymal stromal cells is required for post-natal and infection-dependent thymus remodelling and regeneration.
FEBS open bio 2012;2():187-90.
2012: Sandeep N Shah; ELIAS ZAMBIDIS; Amy Belton; Leslie Cope; Joelle Anne Hillion; David L Huso; Candace Kerr; Cyndi Liu; Linda M. Resar
HMGA1 reprograms somatic cells into pluripotent stem cells by inducing stem cell transcriptional networks.
PloS one 2012;7(11):e48533.
2012: Eva Andres-Mateos; Tyesha N Burks; David L Huso; Leslie A Leinwand; Benjamin Lin; Brian M Lin; Tom G Marr; RUTH MARX-RATTNER; Rebeca Mejias; Dana K Merriman; Arshia Soleimani; RICHARD ZELLARS; Yonggang Zhang; Ronald D Cohn
Impaired skeletal muscle regeneration in the absence of fibrosis during hibernation in 13-lined ground squirrels.
PloS one 2012;7(11):e48884.
2012: Amy Belton; Alexander Gabrovsky; David L Huso; Christine A Iacobuzio-Donahue; Ray Reeves; Young Kyung Bae; Linda M. Resar
HMGA1 induces intestinal polyposis in transgenic mice and drives tumor progression and stem cell properties in colon cancer cells.
PloS one 2012;7(1):e30034.
2012: Kristin Lohr; Abdel Rahim A Hamad; Seakwoo Lee; Feng Wu; Hardik Sardana; David L Huso; Shukti Chakravarti
Extracellular matrix protein lumican regulates inflammation in a mouse model of colitis.
Inflammatory bowel diseases 2012;18(1):143-51.
2011: Li Li; Emily Bailey; Sarah Greenblatt; David L Huso; Donald Small
Loss of the wild-type allele contributes to myeloid expansion and disease aggressiveness in FLT3/ITD knockin mice.
Blood 2011;118(18):4935-45.
2011: Vered Stearns; Karineh Tarpinian; Theodore Tsangaris; Takahiro Yoshida; Zhe Zhang; Regina J Brown; Edward Gabrielson; David L Huso; LISA JACOBS; Stacie Jeter; NAGI KHOURI; Scott L Kominsky; Julie R Lange; Tsuyoshi Mori; Penny Powers; Michelle A Rudek; Saraswati Sukumar
Preclinical and clinical evaluation of intraductally administered agents in early breast cancer.
Science translational medicine 2011;3(106):106ra108.
2011: Andrew C Goodwin; Amy Hacker-Prietz; David L Huso; Tracy Murray-Stewart; Shervin Rabizadeh; Cynthia L Sears; Christina E Destefano Shields; Patrick M Woster; Shaoguang Wu; XinQun Wu; Robert A Casero
Polyamine catabolism contributes to enterotoxigenic Bacteroides fragilis-induced colon tumorigenesis.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(37):15354-9.
2011: Helai P Mohammad; H S Prevas; DAVID WATKINS; M Zhang; W Zhang; James G Herman; Craig M Hooker; David L Huso; Baktiar O Karim; B R Leadem; Stephen B Baylin
Loss of a single Hic1 allele accelerates polyp formation in Apc(Δ716) mice.
Oncogene 2011;30(23):2659-69.
2011: Andrew Schuldenfrei; C Conover Talbot; Jeanne Kowalski; Weijie Poh; Sandeep N Shah; Amy Belton; Francescopaolo Di Cello; Hua-Ling Tsai; David L Huso; Tait H Huso; Linda M. Resar
HMGA1 drives stem cell, inflammatory pathway, and cell cycle progression genes during lymphoid tumorigenesis.
BMC genomics 2011;12():549.
2011: David L Huso; Harald Jüppner; Michael A. Levine; William Schwindinger; Yingli Wang; Sarah Edie; Emily L Germain-Lee
Heterotopic ossifications in a mouse model of albright hereditary osteodystrophy.
PloS one 2011;6(6):e21755.
2011: Francesca Scrimieri; Eric S Calhoun; Kalpesh Patel; RIGU GUPTA; David L Huso; Ralph Hruban; Scott E Kern
FAM190A rearrangements provide a multitude of individualized tumor signatures and neo-antigens in cancer.
Oncotarget 2011;2(1-2):69-75.
2010: Oleg Schmidt-Kittler; Jiuxiang Zhu; Jian Yang; Guosheng Liu; William Hendricks; Christoph Lengauer; Sandra B. Gabelli; Kenneth W Kinzler; Bert Vogelstein; David L Huso; Shibin Zhou
PI3Kα inhibitors that inhibit metastasis.
Oncotarget 2010;1(5):339-48.
2010: Siân Lax; Debbie L Hardie; Amy Wilson; Mike R Douglas; Graham Anderson; David L Huso; Clare M Isacke; Christopher D Buckley
The pericyte and stromal cell marker CD248 (endosialin) is required for efficient lymph node expansion.
European journal of immunology 2010;40(7):1884-9.
2010: Benjamin Orsburn; Beatriz Escudero; Mansi Prakash; Silvia Gesheva; Guosheng Liu; David L Huso; Sonia Franco
Differential requirement for H2AX and 53BP1 in organismal development and genome maintenance in the absence of poly(ADP)ribosyl polymerase 1.
Molecular and cellular biology 2010;30(10):2341-52.
2010: Munekazu Yamakuchi; Craig D Lotterman; Clare Bao; Ralph Hruban; Baktiar O Karim; Joshua T Mendell; David L Huso; Charles J Lowenstein
P53-induced microRNA-107 inhibits HIF-1 and tumor angiogenesis.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(14):6334-9.
2010: Peter Matt; David L Huso; JENNIFER HABASHI; Tammy Holm; Jeff Doyle; Florian Schoenhoff; Guosheng Liu; James H Black; Jennifer E Van Eyk; Harry C Dietz
Murine model of surgically induced acute aortic dissection type A.
The Journal of thoracic and cardiovascular surgery 2010;139(4):1041-7.
2010: Chunyang Lien; Chee-Mun Fang; David L Huso; Ferenc Livak; Runqing Lu; PAULA PITHA-ROWE
Critical role of IRF-5 in regulation of B-cell differentiation.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(10):4664-8.
2010: Kajsa Ericson; Christine Gan; Ian Cheong; Carlo Rago; Yardena Samuels; Victor E Velculescu; Kenneth W Kinzler; David L Huso; Bert Vogelstein; Nickolas Papadopoulos
Genetic inactivation of AKT1, AKT2, and PDPK1 in human colorectal cancer cells clarifies their roles in tumor growth regulation.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(6):2598-603.
2010: Miguel A Garcia-Gonzalez; Patricia Outeda; Qin Zhou; Fang Zhou; Luis F Menezes; Feng Qian; David L Huso; Gregory G Germino; Klaus B Piontek; Terry Watnick
Pkd1 and Pkd2 are required for normal placental development.
PloS one 2010;5(9):.
2010: Yingli Wang; Miao Sun; Victoria L Uhlhorn; Xueyan Zhou; Inga Peter; Neus Martinez-Abadias; Cheryl A Hill; Christopher J Percival; Joan T Richtsmeier; David L Huso; Ethylin Jabs
Activation of p38 MAPK pathway in the skull abnormalities of Apert syndrome Fgfr2(+P253R) mice.
BMC developmental biology 2010;10():22.
2009: Eva Andres-Mateos; Rebeca Mejias; Masayuki Sasaki; Xiaojie Li; Brian M Lin; Saskia Biskup; Li Zhang; Rebecca Banerjee; Bobby Thomas; Lichuan Yang; Guosheng Liu; M Flint Beal; David L Huso; Ted M Dawson; Valina Dawson
Unexpected lack of hypersensitivity in LRRK2 knock-out mice to MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine).
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(50):15846-50.
2009: Hong Song; Robert F Hobbs; Ravy Vajravelu; David L Huso; Caroline Esaias; Christos Apostolidis; Alfred Morgenstern; George Sgouros
Radioimmunotherapy of breast cancer metastases with alpha-particle emitter 225Ac: comparing efficacy with 213Bi and 90Y.
Cancer research 2009;69(23):8941-8.
2009: Qibin Zhang; Jian Zhi Hu; Donald N Rommereim; Mark K Murphy; Richard P Phipps; David L Huso; John F Dicello
Application of high-resolution 1H MAS NMR spectroscopy to the analysis of intact bones from mice exposed to gamma radiation.
Radiation research 2009;172(5):607-16.
2009: Shaoguang Wu; Ki-Jong Rhee; Emilia Albesiano; Shervin Rabizadeh; Xinqun Wu; Hung-Rong Yen; David L Huso; frederick brancati; Elizabeth C Wick; Florencia McAllister; Franck Housseau; Drew M Pardoll; Cynthia L Sears
A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses.
Nature medicine 2009;15(9):1016-22.
2009: Peter Matt; Florian Schoenhoff; JENNIFER HABASHI; Tammy Holm; Christel Van Erp; David Loch; Olga D Carlson; Benjamin F Griswold; Qin Fu; Julie De Backer; Bart Loeys; David L Huso; Nazli B McDonnell; Jennifer E Van Eyk; Harry C Dietz
Circulating transforming growth factor-beta in Marfan syndrome.
Circulation 2009;120(6):526-32.
2009: Ki-Jong Rhee; Shaoguang Wu; Xinqun Wu; David L Huso; Baktiar O Karim; Augusto A. Franco-Mora; Shervin Rabizadeh; Jonathan E Golub; Lauren E Mathews; Jai Shin; Ryan Sartor; Douglas Golenbock; Abdel Rahim A Hamad; Christine M Gan; Franck Housseau; Cynthia L Sears
Induction of persistent colitis by a human commensal, enterotoxigenic Bacteroides fragilis, in wild-type C57BL/6 mice.
Infection and immunity 2009;77(4):1708-18.
2009: Denise A Schultz; John E Sagartz; David L Huso; R Mark L Buller
Experimental infection of an African dormouse (Graphiurus kelleni) with monkeypox virus.
Virology 2009;383(1):86-92.
2009: Eleanor B Carson-Walter; Bethany N Winans; Melissa C Whiteman; Yang Liu; Sally Jarvela; Hannu Haapasalo; Betty M. Tyler; David L Huso; Mahlon D Johnson; Kevin A Walter
Characterization of TEM1/endosialin in human and murine brain tumors.
BMC cancer 2009;9():417.
2008: Keiji Yoshinaga; Hiroto Obata; Vladimir Jurukovski; Roberta Mazzieri; Yan Chen; Lior Zilberberg; David L Huso; Jonathan Melamed; Petra Prijatelj; Vesna Todorovic; Branka Dabovic; Daniel B Rifkin
Perturbation of transforming growth factor (TGF)-beta1 association with latent TGF-beta binding protein yields inflammation and tumors.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(48):18758-63.
2008: Hong Song; Karineh Shahverdi; David L Huso; Yuchuan Wang; James J Fox; Robert F Hobbs; Barjor Gimi; Kathleen L Gabrielson; Martin G Pomper; Benjamin M W Tsui; Zaver M Bhujwalla; Richard T. Reilly; George Sgouros
An immunotolerant HER-2/neu transgenic mouse model of metastatic breast cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(19):6116-24.
2008: Francescopaolo Di Cello; Joelle Anne Hillion; Jeanne Kowalski; Brigitte M Ronnett; Abimbola Aderinto; David L Huso; Linda M. Resar
Cyclooxygenase inhibitors block uterine tumorigenesis in HMGA1a transgenic mice and human xenografts.
Molecular cancer therapeutics 2008;7(7):2090-5.
2008: Baktiar O Karim; Syed Z Ali; Jennifer Landolfi; Jill F Mann; Guosheng Liu; Archie Christian; John F Dicello; Dorothy L Rosenthal; David L Huso
Cytomorphologic differentiation of benign and malignant mammary tumors in fine needle aspirate specimens from irradiated female Sprague-Dawley rats.
Veterinary clinical pathology / American Society for Veterinary Clinical Pathology 2008;37(2):229-36.
2008: Hong Song; Karineh Shahverdi; David L Huso; Caroline Esaias; James Fox; Alyson Liedy; Allison Liedy; Zhe Zhang; Richard T. Reilly; Christos Apostolidis; Alfred Morgenstern; George Sgouros
213Bi (alpha-emitter)-antibody targeting of breast cancer metastases in the neu-N transgenic mouse model.
Cancer research 2008;68(10):3873-80.
2008: Sungwoo Ryoo; Gaurav Gupta; Alexandre Benjo; Hyun Kyo Lim; Andre Camara; Gautam Sikka; Hyun Kyo Lim; Jayson Sohi; Lakshmi Santhanam; Kevin G Soucy; Eric Tuday; Ezra Baraban; Monica Ilies; Gary Gerstenblith; Daniel Nyhan; Artin A Shoukas; David W Christianson; Nicholas J Alp; Hunter C Champion; David L Huso; Dan E Berkowitz
Endothelial arginase II: a novel target for the treatment of atherosclerosis.
Circulation research 2008;102(8):923-32.
2008: Li Li; Obdulio Piloto; Ho Bao Nguyen; Kathleen Greenberg; Kogo Takamiya; Frederick Racke; David L Huso; Donald Small
Knock-in of an internal tandem duplication mutation into murine FLT3 confers myeloproliferative disease in a mouse model.
Blood 2008;111(7):3849-58.
2008: Albena T Dinkova-Kostova; Stephanie N Jenkins; Scott L Wehage; David L Huso; Andrea L Benedict; Katherine K Stephenson; Jed W Fahey; Hua Liu; Karen T Liby; Tadashi Honda; Gordon W Gribble; Michael B. Sporn; Paul Talalay
A dicyanotriterpenoid induces cytoprotective enzymes and reduces multiplicity of skin tumors in UV-irradiated mice.
Biochemical and biophysical research communications 2008;367(4):859-65.
2008: Guo N Huang; David L Huso; Samuel Bouyain; Jianchen Tu; Kelly A McCorkell; Michael May; Yuwen Zhu; Michael Lutz; Samuel Collins; Marlin H Dehoff; Shin Kang; Katharine A Whartenby; Jonathan D Powell; Daniel J Leahy; Paul F Worley
NFAT binding and regulation of T cell activation by the cytoplasmic scaffolding Homer proteins.
Science (New York, N.Y.) 2008;319(5862):476-81.
2007: Klaus B Piontek; Luis F Menezes; Miguel A Garcia-Gonzalez; David L Huso; Gregory G Germino
A critical developmental switch defines the kinetics of kidney cyst formation after loss of Pkd1.
Nature medicine 2007;13(12):1490-5.
2007: Peter Matt; Zongming Fu; Thierry Carrel; David L Huso; Stefan Dirnhofer; Ivan Lefkovits; Hans Zerkowski; Jennifer E Van Eyk
Proteomic alterations in heat shock protein 27 and identification of phosphoproteins in ascending aortic aneurysm associated with bicuspid and tricuspid aortic valve.
Journal of molecular and cellular cardiology 2007;43(6):792-801.
2007: Shervin Rabizadeh; Ki-Jong Rhee; Shaoguang Wu; David L Huso; Christine M Gan; Jonathan E Golub; XinQun Wu; Ming Zhang; Cynthia L Sears
Enterotoxigenic bacteroides fragilis: a potential instigator of colitis.
Inflammatory bowel diseases 2007;13(12):1475-83.
2007: William O Osburn; Baktiar O Karim; Patrick Dolan; Guosheng Liu; Masayuki Yamamoto; David L Huso; Thomas W Kensler
Increased colonic inflammatory injury and formation of aberrant crypt foci in Nrf2-deficient mice upon dextran sulfate treatment.
International journal of cancer. Journal international du cancer 2007;121(9):1883-91.
2007: Carlo Rago; David L Huso; Frank Diehl; Baktiar O Karim; Guosheng Liu; Nickolas Papadopoulos; Yardena Samuels; Victor E Velculescu; Bert Vogelstein; Kenneth W Kinzler; Luis Alberto Diaz
Serial assessment of human tumor burdens in mice by the analysis of circulating DNA.
Cancer research 2007;67(19):9364-70.
2007: Shingo Baba; James M Engles; David L Huso; Takayoshi Ishimori; Richard L Wahl
Comparison of uptake of multiple clinical radiotracers into brown adipose tissue under cold-stimulated and nonstimulated conditions.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2007;48(10):1715-23.
2007: Miguel A Garcia-Gonzalez; Luis F Menezes; Klaus B Piontek; Junya Kaimori; David L Huso; Terry Watnick; Luiz F Onuchic; Lisa M Guay-Woodford; Gregory G Germino
Genetic interaction studies link autosomal dominant and recessive polycystic kidney disease in a common pathway.
Human molecular genetics 2007;16(16):1940-50.
2007: Abeba Tesfaye; Francescopaolo Di Cello; Joelle Anne Hillion; Brigitte M Ronnett; Ossama Elbahloul; Raheela Ashfaq; Surajit Dhara; Edward Prochownik; Kathryn Tworkoski; Raymond Reeves; Richard B S Roden; Lora Hedrick Ellenson; David L Huso; Linda M. Resar
The high-mobility group A1 gene up-regulates cyclooxygenase 2 expression in uterine tumorigenesis.
Cancer research 2007;67(9):3998-4004.
2007: Brenda R Baldwin; Li Li; Kam-Fai Tse; S Small; Michael I Collector; Katharine A Whartenby; Saul J Sharkis; F Racke; David L Huso; Donald Small
Transgenic mice expressing Tel-FLT3, a constitutively activated form of FLT3, develop myeloproliferative disease.
Leukemia 2007;21(4):764-71.
2006: Yi Fu Zhou; MARTA BOSCH; Hiroaki Okuyama; Balaji Krishnamachary; Hideo Kimura; Li Zhang; David L Huso; Gregg L Semenza
Spontaneous transformation of cultured mouse bone marrow-derived stromal cells.
Cancer research 2006;66(22):10849-54.
2006: Anjana Yadav; Shibani Pati; Anhthu Nyugen; Oxana Barabitskaja; Prosanta Mondal; Michael Anderson; Robert C Gallo; David L Huso; William Reid
HIV-1 transgenic rat CD4+ T cells develop decreased CD28 responsiveness and suboptimal Lck tyrosine dephosphorylation following activation.
Virology 2006;353(2):357-65.
2006: Obdulio Piloto; Bao Nguyen; David L Huso; Kyu-Tae Kim; Yiwen Li; Larry Witte; Daniel J Hicklin; Patrick Brown; Donald Small
IMC-EB10, an anti-FLT3 monoclonal antibody, prolongs survival and reduces nonobese diabetic/severe combined immunodeficient engraftment of some acute lymphoblastic leukemia cell lines and primary leukemic samples.
Cancer research 2006;66(9):4843-51.
2006: JENNIFER HABASHI; Daniel P Judge; Tammy M Holm; Ronald D Cohn; Bart Loeys; Timothy K Cooper; Loretha Myers; Erin C Klein; Guosheng Liu; Carla Calvi; Megan Podowski; Enid R Neptune; Marc K Halushka; Djahida Bedja; Kathleen L Gabrielson; Daniel B Rifkin; Luca Carta; Francesco Ramirez; David L Huso; Harry C Dietz
Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome.
Science (New York, N.Y.) 2006;312(5770):117-21.
2006: Akash Nanda; Baktiar O Karim; Zhongsheng Peng; Guosheng Liu; Weiping Qiu; Christine Gan; Bert Vogelstein; Brad St Croix; Kenneth W Kinzler; David L Huso
Tumor endothelial marker 1 (Tem1) functions in the growth and progression of abdominal tumors.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(9):3351-6.
2006: Satoshi Murata; Scott L Kominsky; Mustafa Vali; Zhe Zhang; Elizabeth Garrett-Mayer; Dorian Korz; David L Huso; Sharyn D Baker; James Barber; Elizabeth M Jaffee; Richard T. Reilly; Saraswati Sukumar
Ductal access for prevention and therapy of mammary tumors.
Cancer research 2006;66(2):638-45.
2005: Ling-Yang Hao; Mary Armanios; Margaret A Strong; Baktiar O Karim; David M. Feldser; David L Huso; Carol W Greider
Short telomeres, even in the presence of telomerase, limit tissue renewal capacity.
Cell 2005;123(6):1121-31.
2005: Luis Alberto Diaz; Ian Cheong; Catherine A Foss; Xiaosong Zhang; Brock A Peters; Nishant Agrawal; Chetan Bettegowda; Baktiar O Karim; Guosheng Liu; Khalid Khan; Xin Huang; Manu Kohli; Long H Dang; PAUL HWANG; Ahava Vogelstein; Elizabeth Garrett-Mayer; BARRY KOBRIN; Martin G Pomper; Shibin Zhou; Kenneth W Kinzler; Bert Vogelstein; David L Huso
Pharmacologic and toxicologic evaluation of C. novyi-NT spores.
Toxicological sciences : an official journal of the Society of Toxicology 2005;88(2):562-75.
2005: Sylvia J Singletary; Alan J Kirsch; Julie Watson; Baktiar O Karim; David L Huso; Patricia D Hurn; Stephanie J Murphy
Lack of correlation of vaginal impedance measurements with hormone levels in the rat.
Contemporary topics in laboratory animal science / American Association for Laboratory Animal Science 2005;44(6):37-42.
2005: Emily L Germain-Lee; William Schwindinger; Janet L Crane; Rediet Zewdu; Larry S Zweifel; Gary S Wand; David L Huso; Motoyasu Saji; Matthew D Ringel; Michael Levine
A mouse model of albright hereditary osteodystrophy generated by targeted disruption of exon 1 of the Gnas gene.
Endocrinology 2005;146(11):4697-709.
2005: Norman C Peterson; Matthew D Servinsky; Archie Christian; Zhongsheng Peng; Weiping Qiu; Jill Mann; John F Dicello; David L Huso
Tamoxifen resistance and Her2/neu expression in an aged, irradiated rat breast carcinoma model.
Carcinogenesis 2005;26(9):1542-52.
2005: Yingli Wang; Ran Xiao; Fan Yang; Baktiar O Karim; Anthony J Iacovelli; Juanliang Cai; Charles P Lerner; Joan T Richtsmeier; Jen M Leszl; Cheryl A Hill; Kai Yu; David M Ornitz; Jennifer H Elisseeff; David L Huso; Ethylin Jabs
Abnormalities in cartilage and bone development in the Apert syndrome FGFR2(+/S252W) mouse.
Development (Cambridge, England) 2005;132(15):3537-48.
2005: Rebecca C Osthus; Baktiar O Karim; Julia E Prescott; B Douglas Smith; A MICHAEL MCDEVITT; David L Huso; Chi Dang
The Myc target gene JPO1/CDCA7 is frequently overexpressed in human tumors and has limited transforming activity in vivo.
Cancer research 2005;65(13):5620-7.
2005: Ling Qi; Margaret A Strong; Baktiar O Karim; David L Huso; Carol W Greider
Telomere fusion to chromosome breaks reduces oncogenic translocations and tumour formation.
Nature cell biology 2005;7(7):706-11.
2005: Yardena Samuels; Luis Alberto Diaz; Oleg Schmidt-Kittler; Jordan M Cummins; Laura Delong; Ian Cheong; Carlo Rago; David L Huso; Christoph Lengauer; Kenneth W Kinzler; Bert Vogelstein; Victor E Velculescu
Mutant PIK3CA promotes cell growth and invasion of human cancer cells.
Cancer cell 2005;7(6):561-73.
2005: Obdulio Piloto; Mark Levis; David L Huso; Yiwen Li; Hongli Li; Mei-Nai Wang; Rajiv Bassi; Paul Balderes; Dale L Ludwig; Larry Witte; Zhenping Zhu; Daniel J Hicklin; Donald Small
Inhibitory anti-FLT3 antibodies are capable of mediating antibody-dependent cell-mediated cytotoxicity and reducing engraftment of acute myelogenous leukemia blasts in nonobese diabetic/severe combined immunodeficient mice.
Cancer research 2005;65(4):1514-22.
2005: Yuchuan Wang; David L Huso; Jenny Harrington; J Kellner; D K Jeong; J Turney; Ian K McNiece
Outgrowth of a transformed cell population derived from normal human BM mesenchymal stem cell culture.
Cytotherapy 2005;7(6):509-19.
2005: D Bruce Vaupel; Srihari R Tella; David L Huso; Valentine O Wagner; Alexey G Mukhin; Svetlana I Chefer; Andrew G Horti; Edythe D London; Andrei O KoreN; Alane S Kimes
Pharmacological and toxicological evaluation of 2-fluoro-3-(2(S)-azetidinylmethoxy)pyridine (2-F-A-85380), a ligand for imaging cerebral nicotinic acetylcholine receptors with positron emission tomography.
The Journal of pharmacology and experimental therapeutics 2005;312(1):355-65.
2004: Klaus B Piontek; David L Huso; Alexander Grinberg; Lijuan Liu; Djahida Bedja; Haidan Zhao; Kathleen L Gabrielson; Feng Qian; Changlin Mei; Heiner Westphal; Gregory G Germino
A functional floxed allele of Pkd1 that can be conditionally inactivated in vivo.
Journal of the American Society of Nephrology : JASN 2004;15(12):3035-43.
2004: Nishant Agrawal; Chetan Bettegowda; Ian Cheong; Jean-Francois H Geschwind; Charles G Drake; Edward L Hipkiss; Mitsuaki Tatsumi; Long H Dang; Luis Alberto Diaz; Martin G Pomper; Mohammad Abusedera; Richard L Wahl; Kenneth W Kinzler; Shibin Zhou; David L Huso; Bert Vogelstein
Bacteriolytic therapy can generate a potent immune response against experimental tumors.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(42):15172-7.
2004: John F Dicello; Archie Christian; F A Cucinotta; Daila S Gridley; R Kathirithamby; J Mann; A R Markham; Michael F Moyers; G R Novak; Steven Piantadosi; R Ricart-Arbona; D M Simonson; J D Strandberg; M Vazquez; J R Williams; YIMAO ZHANG; H Zhou; David L Huso
In vivo mammary tumourigenesis in the Sprague-Dawley rat and microdosimetric correlates.
Physics in medicine and biology 2004;49(16):3817-30.
2004: Daniel P Judge; Nancy J Biery; Douglas R Keene; Jessica Geubtner; Loretha Myers; David L Huso; Lynn Y Sakai; Harry C Dietz
Evidence for a critical contribution of haploinsufficiency in the complex pathogenesis of Marfan syndrome.
The Journal of clinical investigation 2004;114(2):172-81.
2004: Yi Xu; Takita Felder Sumter; Raka Bhattacharya; Abeba Tesfaye; Ephraim J Fuchs; Lisa J Wood; David L Huso; Linda M. Resar
The HMG-I oncogene causes highly penetrant, aggressive lymphoid malignancy in transgenic mice and is overexpressed in human leukemia.
Cancer research 2004;64(10):3371-5.
2004: Lin-Quan Sun; David W Lee; Quangeng Zhang; Weihong Xiao; Eric Hutton Raabe; Alan K Meeker; Dengshun Miao; David L Huso; Robert J Arceci
Growth retardation and premature aging phenotypes in mice with disruption of the SNF2-like gene, PASG.
Genes & development 2004;18(9):1035-46.
2004: William Reid; Sayed F Abdelwahab; Mariola Sadowska; David L Huso; Ashley Neal; Aaron Ahearn; Joseph L Bryant; Robert C Gallo; George K Lewis; Marvin Reitz
HIV-1 transgenic rats develop T cell abnormalities.
Virology 2004;321(1):111-9.
2004: Long H Dang; Chetan Bettegowda; Nishant Agrawal; Ian Cheong; David L Huso; Philip Frost; Frank Loganzo; Lee M Greenberger; Jozsef Barkoczy; George R Pettit; Amos B Smith; Hallur Gurulingappa; Saeed R Khan; Giovanni Parmigiani; Kenneth W Kinzler; Shibin Zhou; Bert Vogelstein
Targeting vascular and avascular compartments of tumors with C. novyi-NT and anti-microtubule agents.
Cancer biology & therapy 2004;3(3):326-37.
2003: Chetan Bettegowda; Long H Dang; Ross Abrams; David L Huso; Larry E Dillehay; Ian Cheong; Nishant Agrawal; Scott Borzillary; J Michael McCaffery; E Latice Watson; Kuo-Shyan Lin; Fred Bunz; Kwamena Baidoo; Martin G Pomper; Kenneth W Kinzler; Bert Vogelstein; Shibin Zhou
Overcoming the hypoxic barrier to radiation therapy with anaerobic bacteria.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(25):15083-8.
2003: Ling Qi; Margaret A Strong; Baktiar O Karim; Mary Armanios; David L Huso; Carol W Greider
Short telomeres and ataxia-telangiectasia mutated deficiency cooperatively increase telomere dysfunction and suppress tumorigenesis.
Cancer research 2003;63(23):8188-96.
2003: Baktiar O Karim; Jennifer Landolfi; Archie Christian; Rodolfo Ricart-Arbona; Weiping Qiu; Melissa McAlonis; Paul O Eyabi; Khalid A Khan; John F Dicello; Jill F Mann; David L Huso
Estrous cycle and ovarian changes in a rat mammary carcinogenesis model after irradiation, tamoxifen chemoprevention, and aging.
Comparative medicine 2003;53(5):532-8.
2003: Hashmat A Sikder; David L Huso; Hong Zhang; Binghe Wang; Byungwoo Ryu; Sam T Hwang; Jonathan D Powell; Rhoda M Alani
Disruption of Id1 reveals major differences in angiogenesis between transplanted and autochthonous tumors.
Cancer cell 2003;4(4):291-9.
2003: Ching-Tai Huang; David L Huso; Zhenbing Lu; Tianhong Wang; Gang Zhou; Eugene P Kennedy; Charles G Drake; David J Morgan; Linda A Sherman; Amy D Higgins; Drew M Pardoll; Adam J. Adler
CD4+ T cells pass through an effector phase during the process of in vivo tolerance induction.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(8):3945-53.
2002: John E Kratz; duncan stearns; David L Huso; Hilda H Slunt; Donald L Price; David R Borchelt; Charles G Eberhart
Expression of stabilized beta-catenin in differentiated neurons of transgenic mice does not result in tumor formation.
BMC cancer 2002;2():33.
2002: JY Yoo; David L Huso; Daniel Nathans; Stephen Desiderio
Specific ablation of Stat3beta distorts the pattern of Stat3-responsive gene expression and impairs recovery from endotoxic shock.
Cell 2002;108(3):331-44.
2001: Long H Dang; Chetan Bettegowda; David L Huso; Kenneth W Kinzler; Bert Vogelstein
Combination bacteriolytic therapy for the treatment of experimental tumors.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(26):15155-60.
2001: William Reid; Mariola Sadowska; Frank Denaro; SRINIVAS RAO; James S Foulke; N Hayes; O Jones; D Doodnauth; H Davis; Anne M Sill; P O'Driscoll; David L Huso; Timothy R Fouts; George K Lewis; Martha N Hill; Roberta Kamin-Lewis; C Wei; P Ray; Robert C Gallo; Marvin Reitz; Joseph L Bryant
An HIV-1 transgenic rat that develops HIV-related pathology and immunologic dysfunction.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(16):9271-6.
2001: Yanshu Wang; David L Huso; Hugh Cahill; David Ryugo; Jeremy Nathans
Progressive cerebellar, auditory, and esophageal dysfunction caused by targeted disruption of the frizzled-4 gene.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(13):4761-71.
1999: Jay T Bishoff; R B Chen; BR Lee; David Y Chan; David L Huso; Ronald Rodriguez; Louis R Kavoussi; Fray F Marshall
Laparoscopic renal cryoablation: acute and long-term clinical, radiographic, and pathologic effects in an animal model and application in a clinical trial.
Journal of endourology / Endourological Society 1999;13(4):233-9.
1999: AY Yu; Larissa A Shimoda; Narayan Iyer; David L Huso; X Sun; Rita McWilliams; Terri H beaty; James Sham; Charles M Wiener; JIM SYLVESTER; Gregg L Semenza
Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1alpha.
The Journal of clinical investigation 1999;103(5):691-6.
1999: Kai Y Xu; David L Huso; Ted M Dawson; D S Bredt; Lewis C Becker
Nitric oxide synthase in cardiac sarcoplasmic reticulum.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(2):657-62.
1998: S Sankarapandi; Jay L Zweier; G Mukherjee; M T Quinn; David L Huso
Measurement and characterization of superoxide generation in microglial cells: evidence for an NADPH oxidase-dependent pathway.
Archives of biochemistry and biophysics 1998;353(2):312-21.
1997: David L Huso
Neutralizing and fusion-blocking antibodies induced by recombinant visna virus envelope glycoprotein.
Viral immunology 1997;10(1):15-20.
1996: Kathleen L Gabrielson; R L Remillard; David L Huso
Zinc toxicity with pancreatic acinar necrosis in piglets receiving total parenteral nutrition.
Veterinary pathology 1996;33(6):692-6.
1996: V L Haines; P R Brown; Ralph Hruban; David L Huso
Adenocarcinoma of the hepatopancreatic ampulla in a domestic cat.
Veterinary pathology 1996;33(4):439-41.
1995: G Ruble; I K Berzins; David L Huso
Diagnostic exercise: anorexia, wasting, and death in South African clawed frogs.
Laboratory animal science 1995;45(5):592-4.
1989: Pauline E Jolly; David L Huso; G Hart; Opendra Narayan
Modulation of lentivirus replication by antibodies. Non-neutralizing antibodies to caprine arthritis-encephalitis virus enhance early stages of infection in macrophages, but do not cause increased production of virions.
The Journal of general virology 1989;70 ( Pt 8)():2221-6.
1989: Pauline E Jolly; David L Huso; D Sheffer; Opendra Narayan
Modulation of lentivirus replication by antibodies: Fc portion of immunoglobulin molecule is essential for enhancement of binding, internalization, and neutralization of visna virus in macrophages.
Journal of virology 1989;63(4):1811-3.
1988: Opendra Narayan; MARY ZINK; David L Huso; D Sheffer; S Crane; S Kennedy-Stoskopf; Pauline E Jolly; Janice E Clements
Lentiviruses of animals are biological models of the human immunodeficiency viruses.
Microbial pathogenesis 1988;5(3):149-57.
1988: David L Huso; Opendra Narayan; Gerald W Hart
Sialic acids on the surface of caprine arthritis-encephalitis virus define the biological properties of the virus.
Journal of virology 1988;62(6):1974-80.

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