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Isa Hussaini

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Jonathan H Sherman; Gerard T Redpath; Jan A Redick; Benjamin W Purow; Edward R Laws; John A Jane; Mark E Shaffrey; Isa M Hussaini
A novel fixative for immunofluorescence staining of CD133-positive glioblastoma stem cells.
Barbara C Merk; Jennifer L Owens; Corinne M Silva; Maria-Beatriz S Lopes; Isa M Hussaini
STAT6 expression in glioblastoma promotes invasive growth.
Melike Mut; Samson Amos; Isa M Hussaini
PKC alpha phosphorylates cytosolic NF-kappaB/p65 and PKC delta delays nuclear translocation of NF-kappaB/p65 in U1242 glioblastoma cells.

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All Publications

2011: Jonathan H Sherman; Gerard T Redpath; Jan A Redick; Benjamin W Purow; Edward R Laws; John A Jane; Mark E Shaffrey; Isa M Hussaini
A novel fixative for immunofluorescence staining of CD133-positive glioblastoma stem cells.
Journal of neuroscience methods 2011;198(1):99-102.
2011: Barbara C Merk; Jennifer L Owens; Corinne M Silva; Maria-Beatriz S Lopes; Isa M Hussaini
STAT6 expression in glioblastoma promotes invasive growth.
BMC cancer 2011;11():184.
2010: Melike Mut; Samson Amos; Isa M Hussaini
PKC alpha phosphorylates cytosolic NF-kappaB/p65 and PKC delta delays nuclear translocation of NF-kappaB/p65 in U1242 glioblastoma cells.
Turkish neurosurgery 2010;20(3):277-85.
2010: Samson Amos; Gerard T Redpath; Charles G diPierro; Joan E Carpenter; Isa M Hussaini
Epidermal growth factor receptor-mediated regulation of urokinase plasminogen activator expression and glioblastoma invasion via C-SRC/MAPK/AP-1 signaling pathways.
Journal of neuropathology and experimental neurology 2010;69(6):582-92.
2010: Yunge Zhao; Aizhen Xiao; Charles G diPierro; Joan E Carpenter; Rana Abdel-Fattah; Gerard T Redpath; M Beatriz S Lopes; Isa M Hussaini
An extensive invasive intracranial human glioblastoma xenograft model: role of high level matrix metalloproteinase 9.
The American journal of pathology 2010;176(6):3032-49.
2010: Zachary M Bush; M Beatriz S Lopes; Isa M Hussaini; John A Jane; Edward R Laws; Mary Lee Vance
Immunohistochemistry of COUP-TFI: an adjuvant diagnostic tool for the identification of corticotroph microadenomas.
Pituitary 2010;13(1):1-7.
2009: Zachary A Kohutek; Charles G diPierro; Gerard T Redpath; Isa M Hussaini
ADAM-10-mediated N-cadherin cleavage is protein kinase C-alpha dependent and promotes glioblastoma cell migration.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(14):4605-15.
2008: Yunge Zhao; Aizhen Xiao; Charles G diPierro; Rana Abdel-Fattah; Samson Amos; Gerard T Redpath; Joan E Carpenter; Russell O Pieper; Isa M Hussaini
H-Ras increases urokinase expression and cell invasion in genetically modified human astrocytes through Ras/Raf/MEK signaling pathway.
Glia 2008;56(8):917-24.
2008: Yunge Zhao; Charles E Lyons; Aizhen Xiao; Dennis J Templeton; Qingxiang Amy Sang; Keith Brew; Isa M Hussaini
Urokinase directly activates matrix metalloproteinases-9: a potential role in glioblastoma invasion.
Biochemical and biophysical research communications 2008;369(4):1215-20.
2008: Yunqing Li; Fadila Guessous; Sherwin Kwon; Manish Kumar; Opeyemi Ibidapo; Lauren Fuller; Elizabeth Johnson; Bachchu Lal; Isa M Hussaini; Yongde Bao; John Laterra; David Schiff; Roger Abounader
PTEN has tumor-promoting properties in the setting of gain-of-function p53 mutations.
Cancer research 2008;68(6):1723-31.
2008: Jian Gong; Yunge Zhao; Rana Abdel-Fattah; Samson Amos; Aizhen Xiao; M Beatriz S Lopes; Isa M Hussaini; Edward R Laws
Matrix metalloproteinase-9, a potential biological marker in invasive pituitary adenomas.
Pituitary 2008;11(1):37-48.
2007: Samson Amos; Melike Mut; Charles G diPierro; Joan E Carpenter; Aizhen Xiao; Zachary A Kohutek; Gerard T Redpath; Yunge Zhao; Jiahu Wang; Mark E Shaffrey; Isa M Hussaini
Protein kinase C-alpha-mediated regulation of low-density lipoprotein receptor related protein and urokinase increases astrocytoma invasion.
Cancer research 2007;67(21):10241-51.
2007: Rosalie M Uht; Samson Amos; Patrick M Martin; A E Riggan; Isa M Hussaini
The protein kinase C-eta isoform induces proliferation in glioblastoma cell lines through an ERK/Elk-1 pathway.
Oncogene 2007;26(20):2885-93.
2007: Patrick M Martin; Sean E Aeder; Carol A Chrestensen; Thomas W Sturgill; Isa M Hussaini
Phorbol 12-myristate 13-acetate and serum synergize to promote rapamycin-insensitive cell proliferation via protein kinase C-eta.
Oncogene 2007;26(3):407-14.
2007: Isa M Hussaini; Christy Trotter; Yunge Zhao; Rana Abdel-Fattah; Samson Amos; Aizhen Xiao; Crystal U Agi; Gerard T Redpath; Zixing Fang; Gilberto Ka Kit Leung; M Beatriz S Lopes; Edward R Laws
Matrix metalloproteinase-9 is differentially expressed in nonfunctioning invasive and noninvasive pituitary adenomas and increases invasion in human pituitary adenoma cell line.
The American journal of pathology 2007;170(1):356-65.
2006: Jiahu Wang; Ningning Wang; Jinling Xie; Staci C Walton; Robert L McKown; Ronald W Raab; Peisong Ma; Shannon L Beck; George L Coffman; Isa M Hussaini; Gordon W Laurie
Restricted epithelial proliferation by lacritin via PKCalpha-dependent NFAT and mTOR pathways.
The Journal of cell biology 2006;174(5):689-700.
2006: R Abdel-Fattah; Aizhen Xiao; D Bomgardner; C-S Pease; M Beatriz S Lopes; Isa M Hussaini
Differential expression of HOX genes in neoplastic and non-neoplastic human astrocytes.
The Journal of pathology 2006;209(1):15-24.
2006: Samson Amos; Gerard T Redpath; G Polar; R McPheson; D Schiff; Isa M Hussaini
Farnesylthiosalicylic acid induces caspase activation and apoptosis in glioblastoma cells.
Cell death and differentiation 2006;13(4):642-51.
2005: Patrick M Martin; Isa M Hussaini
PKC eta as a therapeutic target in glioblastoma multiforme.
Expert opinion on therapeutic targets 2005;9(2):299-313.
2005: Samson Amos; Patrick M Martin; Gregory A Polar; Sarah J Parsons; Isa M Hussaini
Phorbol 12-myristate 13-acetate induces epidermal growth factor receptor transactivation via protein kinase Cdelta/c-Src pathways in glioblastoma cells.
The Journal of biological chemistry 2005;280(9):7729-38.
2004: Sean E Aeder; Patrick M Martin; Jae-Won Soh; Isa M Hussaini
PKC-eta mediates glioblastoma cell proliferation through the Akt and mTOR signaling pathways.
Oncogene 2004;23(56):9062-9.
2004: Kamaleldin E Elagib; Mang Xiao; Isa M Hussaini; Lorrie L Delehanty; Lisa A Palmer; Frederick K Racke; Michael J Birrer; Ganapath Shanmugasundaram; A MICHAEL MCDEVITT; Adam N Goldfarb
Jun blockade of erythropoiesis: role for repression of GATA-1 by HERP2.
Molecular and cellular biology 2004;24(17):7779-94.
2004: Samson Amos; Peter Achunike Akah; Nkechi Mercy Enwerem; Ben A Chindo; Isa M Hussaini; Charles Wambebe; Karniyus Gamaniel
Behavioural effect of Pavetta crassipes extract on rodents.
Pharmacology, biochemistry, and behavior 2004;77(4):751-9.
2003: Samson Amos; Peter Achunike Akah; Lucy Binda; Nkechi Mercy Enwerem; Abiodun Ogundaini; Charles Wambebe; Isa M Hussaini; Karniyus Gamaniel
Hypotensive activity of the ethanol extract of Pavetta crassipes leaves.
Biological & pharmaceutical bulletin 2003;26(12):1674-80.
2003: Julianne J Sando; Jacquelyn K Beals; Isa M Hussaini
Subcellular translocation of protein kinase C.
Methods in molecular biology (Clifton, N.J.) 2003;233():77-85.
2002: Isa M Hussaini; Joan E Carpenter; Gerard T Redpath; Julianne J Sando; Mark E Shaffrey; Scott R Vandenberg
Protein kinase C-eta regulates resistance to UV- and gamma-irradiation-induced apoptosis in glioblastoma cells by preventing caspase-9 activation.
Neuro-oncology 2002;4(1):9-21.
2001: Adam N Goldfarb; Lorrie L Delehanty; D Wang; Frederick K Racke; Isa M Hussaini
Stromal inhibition of megakaryocytic differentiation correlates with blockade of signaling by protein kinase C-epsilon and ERK/MAPK.
The Journal of biological chemistry 2001;276(31):29526-30.
2000: Isa M Hussaini; Y H Zhang; Jeffrey J Lysiak; T Y Shen
Dithiolane analogs of lignans inhibit interferon-gamma and lipopolysaccharide-induced nitric oxide production in macrophages.
Acta pharmacologica Sinica 2000;21(10):897-904.
2000: Isa M Hussaini; LR Karns; G Vinton; Joan E Carpenter; Gerard T Redpath; Julianne J Sando; Scott R Vandenberg
Phorbol 12-myristate 13-acetate induces protein kinase ceta-specific proliferative response in astrocytic tumor cells.
The Journal of biological chemistry 2000;275(29):22348-54.
1999: Isa M Hussaini; MD Brown; Alissa M Weaver; J Carpenter; LR Karns; Scott R Vandenberg; Steven L Gonias
Stable antisense RNA expression neutralizes the activity of low-density lipoprotein receptor-related protein and promotes urokinase accumulation in the medium of an astrocytic tumor cell line.
Antisense & nucleic acid drug development 1999;9(2):183-90.
1999: Isa M Hussaini; MD Brown; LR Karns; J Carpenter; Gerard T Redpath; Steven L Gonias; Scott R Vandenberg
Epidermal growth factor differentially regulates low density lipoprotein receptor-related protein gene expression in neoplastic and fetal human astrocytes.
Glia 1999;25(1):71-84.
1998: James Mandell; Isa M Hussaini; Maja Zecevic; Michael J Weber; Scott R Vandenberg
In situ visualization of intratumor growth factor signaling: immunohistochemical localization of activated ERK/MAP kinase in glial neoplasms.
The American journal of pathology 1998;153(5):1411-23.
1998: L A Stephenson; L B Haney; Isa M Hussaini; LR Karns; William F Glass
Regulation of smooth muscle alpha-actin expression and hypertrophy in cultured mesangial cells.
Kidney international 1998;54(4):1175-87.
1998: DH Nguyen; Isa M Hussaini; Steven L Gonias
Binding of urokinase-type plasminogen activator to its receptor in MCF-7 cells activates extracellular signal-regulated kinase 1 and 2 which is required for increased cellular motility.
The Journal of biological chemistry 1998;273(14):8502-7.
1997: Jeffrey J Lysiak; Isa M Hussaini; Steven L Gonias
alpha 2-Macroglobulin synthesis by the human monocytic cell line THP-1 is differentiation state-dependent.
Journal of cellular biochemistry 1997;67(4):492-7.
1997: Alissa M Weaver; Isa M Hussaini; Andrew P Mazar; Jack Henkin; Steven L Gonias
Embryonic fibroblasts that are genetically deficient in low density lipoprotein receptor-related protein demonstrate increased activity of the urokinase receptor system and accelerated migration on vitronectin.
The Journal of biological chemistry 1997;272(22):14372-9.
1997: MD Brown; Gary Banker; Isa M Hussaini; Steven L Gonias; Scott R Vandenberg
Low density lipoprotein receptor-related protein is expressed early and becomes restricted to a somatodendritic domain during neuronal differentiation in culture.
Brain research 1997;747(2):313-7.
1996: Isa M Hussaini; Jonathan LaMarre; Jeffrey J Lysiak; LR Karns; Scott R Vandenberg; Steven L Gonias
Transcriptional regulation of LDL receptor-related protein by IFN-gamma and the antagonistic activity of TGF-beta(1) in the RAW 264.7 macrophage-like cell line.
Journal of leukocyte biology 1996;59(5):733-9.
1995: Donna J Webb; Isa M Hussaini; Alissa M Weaver; T L Atkins; C T Chu; S V Pizzo; Gary K Owens; Steven L Gonias
Activated alpha 2-macroglobulin promotes mitogenesis in rat vascular smooth muscle cells by a mechanism that is independent of growth-factor-carrier activity.
European journal of biochemistry / FEBS 1995;234(3):714-22.
1995: Jeffrey J Lysiak; Isa M Hussaini; Donna J Webb; W F Glass; M Allietta; Steven L Gonias
Alpha 2-macroglobulin functions as a cytokine carrier to induce nitric oxide synthesis and cause nitric oxide-dependent cytotoxicity in the RAW 264.7 macrophage cell line.
The Journal of biological chemistry 1995;270(37):21919-27.
1994: B B Wolf; C A Gibson; Vivek Kapur; Isa M Hussaini; J M Musser; Steven L Gonias
Proteolytically active streptococcal pyrogenic exotoxin B cleaves monocytic cell urokinase receptor and releases an active fragment of the receptor from the cell surface.
The Journal of biological chemistry 1994;269(48):30682-7.
1993: Steven L Gonias; L B Marshall; N L Figler; Isa M Hussaini; M D Moncino; S V Pizzo
Electron microscopy studies of alpha 2-macroglobulin subunit association after limited reduction with dithiothreitol.
Archives of biochemistry and biophysics 1993;302(1):42-8.
1991: Jonathan LaMarre; M Anthony Hayes; G K Wollenberg; Isa M Hussaini; S W Hall; Steven L Gonias
An alpha 2-macroglobulin receptor-dependent mechanism for the plasma clearance of transforming growth factor-beta 1 in mice.
The Journal of clinical investigation 1991;87(1):39-44.
1990: Isa M Hussaini; K Srikumar; Peter J Quesenberry; Steven L Gonias
Colony-stimulating factor-1 modulates alpha 2-macroglobulin receptor expression in murine bone marrow macrophages.
The Journal of biological chemistry 1990;265(32):19441-6.
1990: Isa M Hussaini; N L Figler; Steven L Gonias
The structure of alpha 2-macroglobulin-methylamine after papain digestion as determined by electron microscopy.
The Biochemical journal 1990;270(2):291-5.
1990: T Y Shen; Isa M Hussaini
Kadsurenone and other related lignans as antagonists of platelet-activating factor receptor.
Methods in enzymology 1990;187():446-54.
1990: T Y Shen; Isa M Hussaini
Further characterization of PAF receptor and novel antagonists.
International journal of tissue reactions 1990;12(2):63-9.
1989: Isa M Hussaini; P K Moore
Sympathomimetic amine-induced potentiation of fibrinolytic activity is partly modulated by endogenous prostaglandins in the rat.
Thrombosis research 1989;55(5):611-7.
1989: Isa M Hussaini; T Y Shen
A specific, photolabile and irreversible antagonist (L662,025) of the PAF-receptor.
Biochemical and biophysical research communications 1989;161(1):23-30.
1989: T Y Shen; Isa M Hussaini; S B Hwang; M N Chang
Recent development of platelet-activating factor antagonists.
Advances in prostaglandin, thromboxane, and leukotriene research 1989;19():359-62.
1988: Isa M Hussaini; P K Moore
Sulphinpyrazone inhibits platelet function and enhances blood fibrinolytic activity in the rat.
Thrombosis research 1988;52(4):337-41.
1988: PK Moore; Isa M Hussaini; R Bhardwaj
Prostanoids stimulate fibrinolysis in the rat.
Archives internationales de pharmacodynamie et de thérapie 1988;296():155-62.
1988: P K Moore; Isa M Hussaini; R Bhardwaj
Sulphasalazine increases fibrinolysis in the anaesthetised rat.
Thrombosis and haemostasis 1988;60(1):121.
1988: PK Moore; Isa M Hussaini; R Bhardwaj
Effect of fibrinopeptides A and B on human and rat platelet aggregation in vitro.
European journal of pharmacology 1988;153(2-3):231-8.
1988: PK Moore; Isa M Hussaini; R Bhardwaj
Cardiovascular effects of fibrinopeptide B.
The Journal of pharmacy and pharmacology 1988;40(8):558-61.