FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Elaine Huston

Research Profile

Chemicals & Drugs

Anatomy

Genes & Molecular Sequences

Amino Acid Sequences

Concepts & Ideas

Living Beings

Physiology

Co-author Network

Publications

TOP 3
Kim M Brown; Frank Christian; Shireen A Davies; Jon P Day; Kornelia Hampel; Miles D Houslay; Elaine Huston; Walter Kolch; Louisa C Y Lee; David B Morton; David Romano; Masami Shimizu-Albergine; Selim Terhzaz; Miranda J Willis; Bastian Zimmermann; Joseph A Beavo; George S Baillie
Phosphodiesterase-8A binds to and regulates Raf-1 kinase.
Jonathan P Day; Barbara Lindsay; Tracy Riddell; Zhong Jiang; Robert W Allcock; Achamma Abraham; Sebastian Sookup; Frank Christian; Jana Bogum; Elisabeth K Martin; Robert L Rae; Diana Anthony; Georgina M Rosair; Daniel M Houslay; Elaine Huston; George S Baillie; Enno Klussmann; Miles D Houslay; David R Adams
Elucidation of a structural basis for the inhibitor-driven, p62 (SQSTM1)-dependent intracellular redistribution of cAMP phosphodiesterase-4A4 (PDE4A4).
Dong Meng; Martin J Lynch; Elaine Huston; Michael Beyermann; Jenny Eichhorst; David R Adams; Enno Klussmann; Enno Klusmann; Miles D Houslay; George S Baillie
MEK1 binds directly to betaarrestin1, influencing both its phosphorylation by ERK and the timing of its isoprenaline-stimulated internalization.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Elaine Huston (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Kim M Brown; Frank Christian; Shireen A Davies; Jon P Day; Kornelia Hampel; Miles D Houslay; Elaine Huston; Walter Kolch; Louisa C Y Lee; David B Morton; David Romano; Masami Shimizu-Albergine; Selim Terhzaz; Miranda J Willis; Bastian Zimmermann; Joseph A Beavo; George S Baillie
Phosphodiesterase-8A binds to and regulates Raf-1 kinase.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(16):E1533-42.
2011: Jonathan P Day; Barbara Lindsay; Tracy Riddell; Zhong Jiang; Robert W Allcock; Achamma Abraham; Sebastian Sookup; Frank Christian; Jana Bogum; Elisabeth K Martin; Robert L Rae; Diana Anthony; Georgina M Rosair; Daniel M Houslay; Elaine Huston; George S Baillie; Enno Klussmann; Miles D Houslay; David R Adams
Elucidation of a structural basis for the inhibitor-driven, p62 (SQSTM1)-dependent intracellular redistribution of cAMP phosphodiesterase-4A4 (PDE4A4).
Journal of medicinal chemistry 2011;54(9):3331-47.
2009: Dong Meng; Martin J Lynch; Elaine Huston; Michael Beyermann; Jenny Eichhorst; David R Adams; Enno Klussmann; Enno Klusmann; Miles D Houslay; George S Baillie
MEK1 binds directly to betaarrestin1, influencing both its phosphorylation by ERK and the timing of its isoprenaline-stimulated internalization.
The Journal of biological chemistry 2009;284(17):11425-35.
2008: Elaine Huston; Martin J Lynch; Ahmed Mohamed; Daniel M Collins; Elaine V Hill; Ruth MacLeod; Eberhard Krause; George S Baillie; Miles D Houslay
EPAC and PKA allow cAMP dual control over DNA-PK nuclear translocation.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(35):12791-6.
2008: A C McCahill; Elaine Huston; Xiang Li; Miles D Houslay
PDE4 associates with different scaffolding proteins: modulating interactions as treatment for certain diseases.
Handbook of experimental pharmacology 2008;(186):125-66.
2006: Elaine Huston; Irene Gall; Thomas M Houslay; Miles D Houslay
Helix-1 of the cAMP-specific phosphodiesterase PDE4A1 regulates its phospholipase-D-dependent redistribution in response to release of Ca2+.
Journal of cell science 2006;119(Pt 18):3799-810.
2006: Elaine Huston; Thomas M Houslay; George S Baillie; Miles D Houslay
cAMP phosphodiesterase-4A1 (PDE4A1) has provided the paradigm for the intracellular targeting of phosphodiesterases, a process that underpins compartmentalized cAMP signalling.
Biochemical Society transactions 2006;34(Pt 4):504-9.
2006: Xiang Li; Elaine Huston; Martin J Lynch; Miles D Houslay; George S Baillie
Phosphodiesterase-4 influences the PKA phosphorylation status and membrane translocation of G-protein receptor kinase 2 (GRK2) in HEK-293beta2 cells and cardiac myocytes.
The Biochemical journal 2006;394(Pt 2):427-35.
2005: J Kirsty Millar; Ben S Pickard; Shaun Mackie; Rachel James; Sheila Christie; Sebastienne R Buchanan; M Pat Malloy; Jennifer E Chubb; Elaine Huston; George S Baillie; Pippa A Thomson; Elaine V Hill; Nicholas J Brandon; Jean-Christophe Rain; L Miguel Camargo; Paul J Whiting; Miles D Houslay; D H R Blackwood; Walter J Muir; David J Porteous
DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling.
Science (New York, N.Y.) 2005;310(5751):1187-91.
2005: Angela McCahill; Theresa McSorley; Elaine Huston; Elaine V Hill; Martin J Lynch; Irene Gall; Guy Keryer; Birgitte Lygren; Kjetil Tasken; Gino van Heeke; Miles D Houslay
In resting COS1 cells a dominant negative approach shows that specific, anchored PDE4 cAMP phosphodiesterase isoforms gate the activation, by basal cyclic AMP production, of AKAP-tethered protein kinase A type II located in the centrosomal region.
Cellular signalling 2005;17(9):1158-73.
2005: Derek A Wallace; Lee Ann Johnston; Elaine Huston; Douglas MacMaster; Thomas M Houslay; York-Fong Cheung; Lachlan Campbell; Jennifer Millen; Robin A Smith; Irene Gall; Richard G Knowles; Michael Sullivan; Miles D Houslay
Identification and characterization of PDE4A11, a novel, widely expressed long isoform encoded by the human PDE4A cAMP phosphodiesterase gene.
Molecular pharmacology 2005;67(6):1920-34.
2004: Marco Mongillo; Theresa McSorley; Sandrine Evellin; Arvind Sood; Valentina Lissandron; Anna Terrin; Elaine Huston; Annette Hannawacker; Martin J Lohse; Tullio Pozzan; Miles D Houslay; Manuela Zaccolo
Fluorescence resonance energy transfer-based analysis of cAMP dynamics in live neonatal rat cardiac myocytes reveals distinct functions of compartmentalized phosphodiesterases.
Circulation research 2004;95(1):67-75.
2004: Lee Ann Johnston; Suat Erdogan; York-Fong Cheung; Michael Sullivan; Rachael Barber; Martin J Lynch; George S Baillie; Gino van Heeke; David R Adams; Elaine Huston; Miles D Houslay
Expression, intracellular distribution and basis for lack of catalytic activity of the PDE4A7 isoform encoded by the human PDE4A cAMP-specific phosphodiesterase gene.
The Biochemical journal 2004;380(Pt 2):371-84.
2003: Graeme B Bolger; Angela McCahill; Elaine Huston; York-Fong Cheung; Theresa McSorley; George S Baillie; Miles D Houslay
The unique amino-terminal region of the PDE4D5 cAMP phosphodiesterase isoform confers preferential interaction with beta-arrestins.
The Journal of biological chemistry 2003;278(49):49230-8.
2003: Robert Terry; York-Fong Cheung; Morten Praestegaard; George S Baillie; Elaine Huston; Irene Gall; David R Adams; Miles D Houslay
Occupancy of the catalytic site of the PDE4A4 cyclic AMP phosphodiesterase by rolipram triggers the dynamic redistribution of this specific isoform in living cells through a cyclic AMP independent process.
Cellular signalling 2003;15(10):955-71.
2003: Graeme B Bolger; Alexander H Peden; Michael R Steele; Carolynn MacKenzie; David G McEwan; Derek A Wallace; Elaine Huston; George S Baillie; Miles D Houslay
Attenuation of the activity of the cAMP-specific phosphodiesterase PDE4A5 by interaction with the immunophilin XAP2.
The Journal of biological chemistry 2003;278(35):33351-63.
2002: George S Baillie; Elaine Huston; Grant Scotland; Matthew N Hodgkin; Irene Gall; Alexander H Peden; Carolynn MacKenzie; Emma S Houslay; Richard Currie; Trevor R Pettitt; Adrian R Walmsley; Michael J O Wakelam; Jim Warwicker; Miles D Houslay
TAPAS-1, a novel microdomain within the unique N-terminal region of the PDE4A1 cAMP-specific phosphodiesterase that allows rapid, Ca2+-triggered membrane association with selectivity for interaction with phosphatidic acid.
The Journal of biological chemistry 2002;277(31):28298-309.
2002: Matthew B Beard; Elaine Huston; Lachlan Campbell; Irene Gall; Ian McPhee; Stephen J Yarwood; Grant Scotland; Miles D Houslay
In addition to the SH3 binding region, multiple regions within the N-terminal noncatalytic portion of the cAMP-specific phosphodiesterase, PDE4A5, contribute to its intracellular targeting.
Cellular signalling 2002;14(5):453-65.
2001: G Rena; F Begg; A Ross; Carolynn MacKenzie; Ian McPhee; Lachlan Campbell; Elaine Huston; Michael Sullivan; Miles D Houslay
Molecular cloning, genomic positioning, promoter identification, and characterization of the novel cyclic amp-specific phosphodiesterase PDE4A10.
Molecular pharmacology 2001;59(5):996-1011.
2000: Elaine Huston; Matthew B Beard; F McCallum; N J Pyne; P Vandenabeele; Grant Scotland; Miles D Houslay
The cAMP-specific phosphodiesterase PDE4A5 is cleaved downstream of its SH3 interaction domain by caspase-3. Consequences for altered intracellular distribution.
The Journal of biological chemistry 2000;275(36):28063-74.
1999: Ian McPhee; Stephen J Yarwood; Grant Scotland; Elaine Huston; Matthew B Beard; AH Ross; Emma S Houslay; Miles D Houslay
Association with the SRC family tyrosyl kinase LYN triggers a conformational change in the catalytic region of human cAMP-specific phosphodiesterase HSPDE4A4B. Consequences for rolipram inhibition.
The Journal of biological chemistry 1999;274(17):11796-810.
1998: Grant Scotland; Matthew B Beard; Suat Erdogan; Elaine Huston; F McCallum; Simon MacKenzie; Alexander H Peden; L Pooley; N G Rena; AH Ross; Stephen J Yarwood; Miles D Houslay
Intracellular compartmentalization of PDE4 cyclic AMP-specific phosphodiesterases.
Methods (San Diego, Calif.) 1998;14(1):65-79.
1997: Elaine Huston; S Lumb; A Russell; C Catterall; AH Ross; Michael R Steele; Graeme B Bolger; Martin J Perry; RJ Owens; Miles D Houslay
Molecular cloning and transient expression in COS7 cells of a novel human PDE4B cAMP-specific phosphodiesterase, HSPDE4B3.
The Biochemical journal 1997;328 ( Pt 2)():549-58.
1997: MM Kostic; Suat Erdogan; G Rena; G Borchert; Brigitte Hoch; Sabine Bartel; Grant Scotland; Elaine Huston; Miles D Houslay; Ernst-Georg Krause
Altered expression of PDE1 and PDE4 cyclic nucleotide phosphodiesterase isoforms in 7-oxo-prostacyclin-preconditioned rat heart.
Journal of molecular and cellular cardiology 1997;29(11):3135-46.
1997: Miles D Houslay; Grant Scotland; Suat Erdogan; Elaine Huston; Simon MacKenzie; J F McCallum; Ian McPhee; L Pooley; G Rena; A Ross; Matthew B Beard; A Peder; F Begg; I Wilkinson; Stephen J Yarwood; C Ackerman; Emma S Houslay; R Hoffman; P Engels; Michael Sullivan; Graeme B Bolger
Intracellular targeting, interaction with Src homology 3 (SH3) domains and rolipram-detected conformational switches in cAMP-specific PDE4A phosphodiesterase.
Biochemical Society transactions 1997;25(2):374-81.
1996: Elaine Huston; L Pooley; P Julien; Grant Scotland; Ian McPhee; Michael Sullivan; Graeme B Bolger; Miles D Houslay
The human cyclic AMP-specific phosphodiesterase PDE-46 (HSPDE4A4B) expressed in transfected COS7 cells occurs as both particulate and cytosolic species that exhibit distinct kinetics of inhibition by the antidepressant rolipram.
The Journal of biological chemistry 1996;271(49):31334-44.