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Sarah Hutchinson

Research Profile

Chemicals & Drugs

Physiology

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HIV-1

Genes & Molecular Sequences

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Publications

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Linda Wooldridge; Anna Lissina; Jonathan Vernazza; Emma Gostick; Bruno Laugel; Sarah L Hutchinson; Mirza Fareed; P Rod Dunbar; Jonathan M Boulter; Meir Glick; Vincenzo Cerundolo; Hugo A van den Berg; David A Price; Andrew K Sewell
Enhanced immunogenicity of CTL antigens through mutation of the CD8 binding MHC class I invariant region.
Emma Gostick; david cole; Sarah L Hutchinson; Linda Wooldridge; Sabrina Tafuro; Bruno Laugel; Anna Lissina; Annette Oxenius; Jonathan M Boulter; David A Price; Andrew K Sewell
Functional and biophysical characterization of an HLA-A*6801-restricted HIV-specific T cell receptor.
Linda Wooldridge; Hugo A van den Berg; Meir Glick; Emma Gostick; Bruno Laugel; Sarah L Hutchinson; Anita Milicic; Jason M Brenchley; Daniel C Douek; David A Price; Andrew K Sewell
Interaction between the CD8 coreceptor and major histocompatibility complex class I stabilizes T cell receptor-antigen complexes at the cell surface.

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All Publications

2007: Linda Wooldridge; Anna Lissina; Jonathan Vernazza; Emma Gostick; Bruno Laugel; Sarah L Hutchinson; Mirza Fareed; P Rod Dunbar; Jonathan M Boulter; Meir Glick; Vincenzo Cerundolo; Hugo A van den Berg; David A Price; Andrew K Sewell
Enhanced immunogenicity of CTL antigens through mutation of the CD8 binding MHC class I invariant region.
European journal of immunology 2007;37(5):1323-33.
2007: Emma Gostick; david cole; Sarah L Hutchinson; Linda Wooldridge; Sabrina Tafuro; Bruno Laugel; Anna Lissina; Annette Oxenius; Jonathan M Boulter; David A Price; Andrew K Sewell
Functional and biophysical characterization of an HLA-A*6801-restricted HIV-specific T cell receptor.
European journal of immunology 2007;37(2):479-86.
2005: Linda Wooldridge; Hugo A van den Berg; Meir Glick; Emma Gostick; Bruno Laugel; Sarah L Hutchinson; Anita Milicic; Jason M Brenchley; Daniel C Douek; David A Price; Andrew K Sewell
Interaction between the CD8 coreceptor and major histocompatibility complex class I stabilizes T cell receptor-antigen complexes at the cell surface.
The Journal of biological chemistry 2005;280(30):27491-501.
2004: A E Green; Anna Lissina; Sarah L Hutchinson; R E Hewitt; B Temple; D James; Jonathan M Boulter; David A Price; Andrew K Sewell
Recognition of nonpeptide antigens by human V gamma 9V delta 2 T cells requires contact with cells of human origin.
Clinical and experimental immunology 2004;136(3):472-82.
2003: Linda Wooldridge; Sarah L Hutchinson; Ed Man-Lik Choi; Anna Lissina; Emma Jones; Mirza Fareed; P Rod Dunbar; David A Price; Vincenzo Cerundolo; Andrew K Sewell
Anti-CD8 antibodies can inhibit or enhance peptide-MHC class I (pMHCI) multimer binding: this is paralleled by their effects on CTL activation and occurs in the absence of an interaction between pMHCI and CD8 on the cell surface.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(12):6650-60.
2003: Sarah L Hutchinson; Linda Wooldridge; Sabrina Tafuro; Bruno Laugel; Meir Glick; Jonathan M Boulter; Bent K Jakobsen; David A Price; Andrew K Sewell
The CD8 T cell coreceptor exhibits disproportionate biological activity at extremely low binding affinities.
The Journal of biological chemistry 2003;278(27):24285-93.
2002: Meir Glick; David A Price; Annelise Vuidepot; Torben B Andersen; Sarah L Hutchinson; Bruno Laugel; Andrew K Sewell; Jonathan M Boulter; P Rod Dunbar; Vincenzo Cerundolo; Annette Oxenius; John I Bell; W Graham Richards; Bent K Jakobsen
Novel CD8+ T cell antagonists based on beta 2-microglobulin.
The Journal of biological chemistry 2002;277(23):20840-6.