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Thomas Hutchinson

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TOP 3
Huw S Jones; Grace H Panter; Henry T Trollope; Thomas H Hutchinson; J Kevin Chipman
Metabolism of ibuprofen in zebrafish larvae.
Abigail E Bartram; Lisa A Constantine; Jon F Ericson; Malcolm J Hetheridge; Duane B Huggett; Thomas H Hutchinson; Lewis B Kinter; Paul McCormack; John P Sumpter; Matthew J Winter; Stewart F Owen
In vivo and in vitro liver and gill EROD activity in rainbow trout (Oncorhynchus mykiss) exposed to the beta-blocker propranolol.
Rhiannon M David; Thomas H Hutchinson; Huw S Jones; Grace H Panter; Matthew J Winter; J Kevin Chipman
Interference with xenobiotic metabolic activity by the commonly used vehicle solvents dimethylsulfoxide and methanol in zebrafish (Danio rerio) larvae but not Daphnia magna.

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All Publications

2012: Huw S Jones; Grace H Panter; Henry T Trollope; Thomas H Hutchinson; J Kevin Chipman
Metabolism of ibuprofen in zebrafish larvae.
Xenobiotica; the fate of foreign compounds in biological systems 2012;42(11):1069-75.
2012: Abigail E Bartram; Lisa A Constantine; Jon F Ericson; Malcolm J Hetheridge; Duane B Huggett; Thomas H Hutchinson; Lewis B Kinter; Paul McCormack; John P Sumpter; Matthew J Winter; Stewart F Owen
In vivo and in vitro liver and gill EROD activity in rainbow trout (Oncorhynchus mykiss) exposed to the beta-blocker propranolol.
Environmental toxicology 2012;27(10):573-82.
2012: Rhiannon M David; Thomas H Hutchinson; Huw S Jones; Grace H Panter; Matthew J Winter; J Kevin Chipman
Interference with xenobiotic metabolic activity by the commonly used vehicle solvents dimethylsulfoxide and methanol in zebrafish (Danio rerio) larvae but not Daphnia magna.
Chemosphere 2012;88(8):912-7.
2011: Emma Giltrow; Thomas H Hutchinson; Paul D Eccles; John P Sumpter; Mariann Rand-Weaver
Characterisation and expression of β1-, β2- and β3-adrenergic receptors in the fathead minnow (Pimephales promelas).
General and comparative endocrinology 2011;173(3):483-90.
2011: R P Ellis; H Parry; John I Spicer; Thomas H Hutchinson; R K Pipe; S Widdicombe
Immunological function in marine invertebrates: Responses to environmental perturbation.
Fish & shellfish immunology 2011;30(6):1209-22.
2010: Stewart F Owen; Duane B Huggett; Thomas H Hutchinson; Malcolm J Hetheridge; Paul McCormack; Lewis B Kinter; Jon F Ericson; Lisa A Constantine; John P Sumpter
The value of repeating studies and multiple controls: replicated 28-day growth studies of rainbow trout exposed to clofibric acid.
Environmental toxicology and chemistry / SETAC 2010;29(12):2831-9.
2010: G H Panter; Thomas H Hutchinson; K S Hurd; J Bamforth; R D Stanley; Jack Wheeler; C R Tyler
Effects of a weak oestrogenic active chemical (4-tert-pentylphenol) on pair-breeding and F1 development in the fathead minnow (Pimephales promelas).
Aquatic toxicology (Amsterdam, Netherlands) 2010;97(4):314-23.
2009: Emma Giltrow; Paul D Eccles; Matthew J Winter; Paul J McCormack; Mariann Rand-Weaver; Thomas H Hutchinson; John P Sumpter
Chronic effects assessment and plasma concentrations of the beta-blocker propranolol in fathead minnows (Pimephales promelas).
Aquatic toxicology (Amsterdam, Netherlands) 2009;95(3):195-202.
2009: Martin Canty; Thomas H Hutchinson; Rebecca J Brown; Malcolm B Jones; Awadhesh N Jha
Linking genotoxic responses with cytotoxic and behavioural or physiological consequences: differential sensitivity of echinoderms (Asterias rubens) and marine molluscs (Mytilus edulis).
Aquatic toxicology (Amsterdam, Netherlands) 2009;94(1):68-76.
2009: Stewart F Owen; Duane B Huggett; Thomas H Hutchinson; Malcolm J Hetheridge; Lewis B Kinter; Jon F Ericson; John P Sumpter
Uptake of propranolol, a cardiovascular pharmaceutical, from water into fish plasma and its effects on growth and organ biometry.
Aquatic toxicology (Amsterdam, Netherlands) 2009;93(4):217-24.
2008: matthew winter; William S Redfern; Amanda J Hayfield; Stewart F Owen; Jean-Pierre Valentin; Thomas H Hutchinson
Validation of a larval zebrafish locomotor assay for assessing the seizure liability of early-stage development drugs.
Journal of pharmacological and toxicological methods 2008;57(3):176-87.
2008: Helen L Hooper; Richard Connon; Amanda Callaghan; Geoffrey Fryer; Sarah Yarwood-Buchanan; Jeremy Biggs; Steve J Maund; Thomas H Hutchinson; Richard M Sibly
The ecological niche of Daphnia magna characterized using population growth rate.
Ecology 2008;89(4):1015-22.
2008: Richard Connon; Helen L Hooper; Richard M Sibly; Fei Ling Lim; Lars-Henrik Heckmann; David Moore; Hajime Watanabe; Anneleen Soetaert; Katie Cook; Steve J Maund; Thomas H Hutchinson; Jonathan Moggs; Wim De Coen; Taisen Iguchi; Amanda Callaghan
Linking molecular and population stress responses in Daphnia magna exposed to cadmium.
Environmental science & technology 2008;42(6):2181-8.
2008: matthew winter; Adam D Lillicrap; John E Caunter; Christian Schaffner; Alfredo C Alder; Maria Ramil; Thomas A Ternes; Emma Giltrow; John P Sumpter; Thomas H Hutchinson
Defining the chronic impacts of atenolol on embryo-larval development and reproduction in the fathead minnow (Pimephales promelas).
Aquatic toxicology (Amsterdam, Netherlands) 2008;86(3):361-9.
2008: Lars-Henrik Heckmann; Richard M Sibly; Richard Connon; Helen L Hooper; Thomas H Hutchinson; Steve J Maund; Christopher J Hill; Anthony Bouetard; Amanda Callaghan
Systems biology meets stress ecology: linking molecular and organismal stress responses in Daphnia magna.
Genome biology 2008;9(2):R40.
2007: Karen L Thorpe; Rachel Benstead; Thomas H Hutchinson; Charles R Tyler
Associations between altered vitellogenin concentrations and adverse health effects in fathead minnow (Pimephales promelas).
Aquatic toxicology (Amsterdam, Netherlands) 2007;85(3):176-83.
2007: Lars-Henrik Heckmann; Amanda Callaghan; Helen L Hooper; Richard Connon; Thomas H Hutchinson; Steve J Maund; Richard M Sibly
Chronic toxicity of ibuprofen to Daphnia magna: Effects on life history traits and population dynamics.
Toxicology letters 2007;172(3):137-45.
2007: matthew winter; Lucy C J Ellis; Thomas H Hutchinson
Formation of micronuclei in erythrocytes of the fathead minnow (Pimephales promelas) after acute treatment with mitomycin C or cyclophosphamide.
Mutation research 2007;629(2):89-99.
2007: Stewart F Owen; Emma Giltrow; Duane B Huggett; Thomas H Hutchinson; Joanne Saye; matthew winter; John P Sumpter
Comparative physiology, pharmacology and toxicology of beta-blockers: mammals versus fish.
Aquatic toxicology (Amsterdam, Netherlands) 2007;82(3):145-62.
2007: Tim D Williams; John E Caunter; Adam D Lillicrap; Thomas H Hutchinson; Edward G Gillings; Stephen Duffell
Evaluation of the reproductive effects of tamoxifen citrate in partial and full life-cycle studies using fathead minnows (Pimephales promelas).
Environmental toxicology and chemistry / SETAC 2007;26(4):695-707.
2007: Karen L Thorpe; Rachel Benstead; Thomas H Hutchinson; Charles R Tyler
An optimised experimental test procedure for measuring chemical effects on reproduction in the fathead minnow, Pimephales promelas.
Aquatic toxicology (Amsterdam, Netherlands) 2007;81(1):90-8.
2007: Thomas H Hutchinson
Small is useful in endocrine disrupter assessment--four key recommendations for aquatic invertebrate research.
Ecotoxicology (London, England) 2007;16(1):231-8.
2006: Helen M Crane; Daniel B Pickford; Thomas H Hutchinson; J Anne Brown
The effects of methimazole on development of the fathead minnow, Pimephales promelas, from embryo to adult.
Toxicological sciences : an official journal of the Society of Toxicology 2006;93(2):278-85.
2006: Grace H Panter; Thomas H Hutchinson; KS Hurd; J Bamforth; R D Stanley; S Duffell; A Hargreaves; S Gimeno; Charles R Tyler
Development of chronic tests for endocrine active chemicals. Part 1. An extended fish early-life stage test for oestrogenic active chemicals in the fathead minnow (Pimephales promelas).
Aquatic toxicology (Amsterdam, Netherlands) 2006;77(3):279-90.
2006: Thomas H Hutchinson; Gerald T Ankley; Helmut Segner; Charles R Tyler
Screening and testing for endocrine disruption in fish-biomarkers as "signposts," not "traffic lights," in risk assessment.
Environmental health perspectives 2006;114 Suppl 1():106-14.
2006: Helen L Noël; Steve P Hopkin; Thomas H Hutchinson; Tim D Williams; Richard M Sibly
Population growth rate and carrying capacity for springtails Folsomia candida exposed to ivermectin.
Ecological applications : a publication of the Ecological Society of America 2006;16(2):656-65.
2006: Thomas H Hutchinson; N Shillabeer; matthew winter; Daniel B Pickford
Acute and chronic effects of carrier solvents in aquatic organisms: a critical review.
Aquatic toxicology (Amsterdam, Netherlands) 2006;76(1):69-92.
2006: Lars-Henrik Heckmann; Richard Connon; Thomas H Hutchinson; Steve J Maund; Richard M Sibly; Amanda Callaghan
Expression of target and reference genes in Daphnia magna exposed to ibuprofen.
BMC genomics 2006;7():175.
2005: Rebecca J Brown; Simon D Rundle; Thomas H Hutchinson; Tim D Williams; Malcolm B Jones
A microplate freshwater copepod bioassay for evaluating acute and chronic effects of chemicals.
Environmental toxicology and chemistry / SETAC 2005;24(6):1528-31.
2005: Helen L Hooper; Richard M Sibly; Thomas H Hutchinson; Steve J Maund
Joint effects of density and a growth inhibitor on the life history and population growth rate of the midge Chironomus riparius.
Environmental toxicology and chemistry / SETAC 2005;24(5):1140-5.
2005: Helen M Crane; Daniel B Pickford; Thomas H Hutchinson; J Anne Brown
Effects of ammonium perchlorate on thyroid function in developing fathead minnows, Pimephales promelas.
Environmental health perspectives 2005;113(4):396-401.
2004: Grace H Panter; Thomas H Hutchinson; KS Hurd; A Sherren; R D Stanley; Charles R Tyler
Successful detection of (anti-)androgenic and aromatase inhibitors in pre-spawning adult fathead minnows (Pimephales promelas) using easily measured endpoints of sexual development.
Aquatic toxicology (Amsterdam, Netherlands) 2004;70(1):11-21.
2004: Helen M Crane; Daniel B Pickford; Thomas H Hutchinson; J Anne Brown
Developmental changes of thyroid hormones in the fathead minnow, Pimephales promelas.
General and comparative endocrinology 2004;139(1):55-60.
2004: Jason R Snape; Steve J Maund; Daniel B Pickford; Thomas H Hutchinson
Ecotoxicogenomics: the challenge of integrating genomics into aquatic and terrestrial ecotoxicology.
Aquatic toxicology (Amsterdam, Netherlands) 2004;67(2):143-54.
2003: Thomas H Hutchinson; Sarah Barrett; Mary Buzby; David Constable; Andreas Hartmann; Eileen Hayes; Duane B Huggett; Reinhard Laenge; Adam D Lillicrap; Jürg Oliver Straub; Roy Thompson
A strategy to reduce the numbers of fish used in acute ecotoxicity testing of pharmaceuticals.
Environmental toxicology and chemistry / SETAC 2003;22(12):3031-6.
2003: Daniel B Pickford; Malcolm J Hetheridge; John E Caunter; A Tilghman Hall; Thomas H Hutchinson
Assessing chronic toxicity of bisphenol A to larvae of the African clawed frog (Xenopus laevis) in a flow-through exposure system.
Chemosphere 2003;53(3):223-35.
2003: Rebecca J Brown; Simon D Rundle; Thomas H Hutchinson; Tim D Williams; Malcolm B Jones
A copepod life-cycle test and growth model for interpreting the effects of lindane.
Aquatic toxicology (Amsterdam, Netherlands) 2003;63(1):1-11.
2003: Karen L Thorpe; Rob I Cummings; Thomas H Hutchinson; Martin Scholze; Geoff Brighty; John P Sumpter; Charles R Tyler
Relative potencies and combination effects of steroidal estrogens in fish.
Environmental science & technology 2003;37(6):1142-9.
2003: S Halm; J Y Kwon; Mariann Rand-Weaver; John P Sumpter; Nadine A Pounds; Thomas H Hutchinson; Charles R Tyler
Cloning and gene expression of P450 17alpha-hydroxylase,17,20-lyase cDNA in the gonads and brain of the fathead minnow Pimephales promelas.
General and comparative endocrinology 2003;130(3):256-66.
2002: Thomas H Hutchinson; Daniel B Pickford
Ecological risk assessment and testing for endocrine disruption in the aquatic environment.
Toxicology 2002;181-182():383-7.
2002: Ronny van Aerle; Nadine A Pounds; Thomas H Hutchinson; Sue Maddix; Charles R Tyler
Window of sensitivity for the estrogenic effects of ethinylestradiol in early life-stages of fathead minnow, Pimephales promelas.
Ecotoxicology (London, England) 2002;11(6):423-34.
2002: S Halm; Nadine A Pounds; Sue Maddix; Mariann Rand-Weaver; John P Sumpter; Thomas H Hutchinson; Charles R Tyler
Exposure to exogenous 17beta-oestradiol disrupts p450aromB mRNA expression in the brain and gonad of adult fathead minnows (Pimephales promelas).
Aquatic toxicology (Amsterdam, Netherlands) 2002;60(3-4):285-99.
2002: Nadine A Pounds; Thomas H Hutchinson; Tim D Williams; Pensri Whiting; Laurence Dinan
Assessment of putative endocrine disrupters in an in vivo crustacean assay and an in vitro insect assay.
Marine environmental research 2002;54(3-5):709-13.
2002: Thomas H Hutchinson
Reproductive and developmental effects of endocrine disrupters in invertebrates: in vitro and in vivo approaches.
Toxicology letters 2002;131(1-2):75-81.
2002: Grace H Panter; Thomas H Hutchinson; Reinhard Länge; Christina M Lye; John P Sumpter; Melanie Zerulla; Charles R Tyler
Utility of a juvenile fathead minnow screening assay for detecting (anti-)estrogenic substances.
Environmental toxicology and chemistry / SETAC 2002;21(2):319-26.
2002: Charles R Tyler; Ronny van Aerle; Mona V Nilsen; Robert Blackwell; Sue Maddix; Bente M Nilsen; Karin Berg; Thomas H Hutchinson; Anders Goksøyr
Monoclonal antibody enzyme-linked immunosorbent assay to quantify vitellogenin for studies on environmental estrogens in the rainbow trout (Oncorhynchus mykiss).
Environmental toxicology and chemistry / SETAC 2002;21(1):47-54.
2001: Laurence Dinan; Pauline Bourne; Pensri Whiting; Tarlochan S Dhadialla; Thomas H Hutchinson
Screening of environmental contaminants for ecdysteroid agonist and antagonist activity using the Drosophila melanogaster B(II) cell in vitro assay.
Environmental toxicology and chemistry / SETAC 2001;20(9):2038-46.
2001: Karen L Thorpe; Thomas H Hutchinson; Malcolm J Hetheridge; Martin Scholze; John P Sumpter; Charles R Tyler
Assessing the biological potency of binary mixtures of environmental estrogens using vitellogenin induction in juvenile rainbow trout (Oncorhynchus mykiss).
Environmental science & technology 2001;35(12):2476-81.
2001: Reinhard Länge; Thomas H Hutchinson; C P Croudace; F Siegmund; Hermann Schweinfurth; P Hampe; Grace H Panter; John P Sumpter
Effects of the synthetic estrogen 17 alpha-ethinylestradiol on the life-cycle of the fathead minnow (Pimephales promelas).
Environmental toxicology and chemistry / SETAC 2001;20(6):1216-27.
2000: Thomas H Hutchinson; R Brown; K E Brugger; P M Campbell; M Holt; Reinhard Länge; P McCahon; L J Tattersfield; Roger van Egmond
Ecological risk assessment of endocrine disruptors.
Environmental health perspectives 2000;108(11):1007-14.
1999: Thomas H Hutchinson; P Matthiessen
Endocrine disruption in wildlife: identification and ecological relevance.
The Science of the total environment 1999;233(1-3):1-3.