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Danny Huylebroeck

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Karen Beets; Danny Huylebroeck; Iván M Moya; Lieve Umans; An Zwijsen
Robustness in angiogenesis: notch and BMP shaping waves.
Gabriel L McKinsey; Len A Pennacchio; Yujiro Higashi; Danny Huylebroeck; Susan Lindtner; Brett Trzcinski; Axel Visel; John L R Rubenstein
Dlx1&2-dependent expression of Zfhx1b (Sip1, Zeb2) regulates the fate switch between cortical and striatal interneurons.
Veronique van den Berghe; Wilfred van Ijcken; Pierre Vanderhaeghen; Bram Vandesande; Elke Stappers; Stein Aerts; Geert Berx; Silvia Cazzola; Andrea Conidi; Jordane Dimidschstein; Ruben Dries; Gord Fishell; Annick Francis; André Goffinet; Steven Goossens; Frank G Grosveld; Jody J Haigh; Danny Huylebroeck; Nicoletta Kessaris; Roel Kroes; Flore Lesage; Eve Seuntjens
Directed migration of cortical interneurons depends on the cell-autonomous action of Sip1.

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All Publications

2013: Karen Beets; Danny Huylebroeck; Iván M Moya; Lieve Umans; An Zwijsen
Robustness in angiogenesis: notch and BMP shaping waves.
Trends in genetics : TIG 2013;29(3):140-9.
2013: Gabriel L McKinsey; Len A Pennacchio; Yujiro Higashi; Danny Huylebroeck; Susan Lindtner; Brett Trzcinski; Axel Visel; John L R Rubenstein
Dlx1&2-dependent expression of Zfhx1b (Sip1, Zeb2) regulates the fate switch between cortical and striatal interneurons.
Neuron 2013;77(1):83-98.
2013: Veronique van den Berghe; Wilfred van Ijcken; Pierre Vanderhaeghen; Bram Vandesande; Elke Stappers; Stein Aerts; Geert Berx; Silvia Cazzola; Andrea Conidi; Jordane Dimidschstein; Ruben Dries; Gord Fishell; Annick Francis; André Goffinet; Steven Goossens; Frank G Grosveld; Jody J Haigh; Danny Huylebroeck; Nicoletta Kessaris; Roel Kroes; Flore Lesage; Eve Seuntjens
Directed migration of cortical interneurons depends on the cell-autonomous action of Sip1.
Neuron 2013;77(1):70-82.
2013: Andrea Conidi; Veronique van den Berghe; Danny Huylebroeck
Aptamers and Their Potential to Selectively Target Aspects of EGF, Wnt/β-Catenin and TGFβ-Smad Family Signaling.
International journal of molecular sciences 2013;14(4):6690-719.
2013: Fernando Gómez-Herreros; Danny Huylebroeck; Limei Ju; Cristina Quintero; Rocío Romero-Granados; Lieve Umans; Liesbeth Vermeire; Zhihong Zeng; Alejandro Alvarez-Quilón; Keith W Caldecott; Felipe Cortés-Ledesma
TDP2-dependent non-homologous end-joining protects against topoisomerase II-induced DNA breaks and genome instability in cells and in vivo.
PLoS genetics 2013;9(3):e1003226.
2012: Paulo N G Pereira; Lieve Umans; Catherine M Verfaillie; Anne Camus; Frederique M Cornelis; Susana M Chuva de Sousa Lopes; Mariya P Dobreva; Danny Huylebroeck; Elke Maas; Iván M Moya; An Zwijsen
Antagonism of Nodal signaling by BMP/Smad5 prevents ectopic primitive streak formation in the mouse amnion.
Development (Cambridge, England) 2012;139(18):3343-54.
2012: Agnès Roy; Eve Seuntjens; Joke Debruyn; Cédric FRANCIUS; Andrea B Huber; Danny Huylebroeck; Georg Luxenhofer; Bennett G Novitch; David L Rousso; Frédéric Clotman
Onecut transcription factors act upstream of Isl1 to regulate spinal motoneuron diversification.
Development (Cambridge, England) 2012;139(17):3109-19.
2012: Zhihong Zeng; Keith W Caldecott; Danny Huylebroeck; Limei Ju; Junko Murai; Yves Pommier; Abhishek Sharma; Shunichi Takeda; Lieve Umans; Liesbeth Vermeire; Sherif F El-Khamisy
TDP2 promotes repair of topoisomerase I-mediated DNA damage in the absence of TDP1.
Nucleic acids research 2012;40(17):8371-80.
2012: Iván M Moya; Christine L Mummery; Paulo N G Pereira; Elizabeth J Robertson; Ward Sents; Lieve Umans; Karen Beets; Annick Francis; Danny Huylebroeck; Elke Maas; An Zwijsen
Stalk cell phenotype depends on integration of Notch and Smad1/5 signaling cascades.
Developmental cell 2012;22(3):501-14.
2012: Qinjie Weng; Xiaomei Xu; Bo Yang; Eve Seuntjens; Elliott H Sherr; Weinian Shou; Veronique van den Berghe; Haibo Wang; Polina Bukshpun; Ying Chen; Yan Chen; Qiaojun He; Yujiro Higashi; Danny Huylebroeck; Steven G Kernie; Q Richard Lu
Dual-mode modulation of Smad signaling by Smad-interacting protein Sip1 is required for myelination in the central nervous system.
Neuron 2012;73(4):713-28.
2012: Abhishek Sohni; Riccardo Bellazzi; Stephen C Ekker; Fulvia Ferrazzi; Danny Huylebroeck; Aernout Luttun; Francesca Mulas; Catherine M Verfaillie
TGFβ1-induced Baf60c regulates both smooth muscle cell commitment and quiescence.
PloS one 2012;7(10):e47629.
2012: Aikaterini Segklia; Eve Seuntjens; Elke Stappers; Sotiris Tsalavos; Maximilianos Elkouris; Danny Huylebroeck; Thimios A Mitsiadis; Eumorphia Remboutsika; Daniel Graf
Bmp7 regulates the survival, proliferation, and neurogenic properties of neural progenitor cells during corticogenesis in the mouse.
PloS one 2012;7(3):e34088.
2011: Monika Jeub; Bruno Pradier; Omneya Taha; Andreas Zimmer; Heinz Beck; Martin Hrabe de Angelis; Michael Emrich; Helmut Fuchs; Valerie Gailus-Durner; Danny Huylebroeck; Ildiko Racz
The transcription factor Smad-interacting protein 1 controls pain sensitivity via modulation of DRG neuron excitability.
Pain 2011;152(10):2384-98.
2011: Steven Goossens; Viktor Janzen; Sonia Bartunkova; Tomomasa Yokomizo; Benjamin Drogat; Mihaela Crisan; Katharina Haigh; Eve Seuntjens; Lieve Umans; Tamara Riedt; Pieter Bogaert; Lieven Haenebalcke; Geert Berx; Elaine Dzierzak; Danny Huylebroeck; Jody J Haigh
The EMT regulator Zeb2/Sip1 is essential for murine embryonic hematopoietic stem/progenitor cell differentiation and mobilization.
Blood 2011;117(21):5620-30.
2011: Paulo N G Pereira; Mariya P Dobreva; Liz Graham; Danny Huylebroeck; Kirstie A Lawson; An Zwijsen
Amnion formation in the mouse embryo: the single amniochorionic fold model.
BMC developmental biology 2011;11():48.
2010: Laure Stanchina; Tom Van de Putte; Michel Goossens; Danny Huylebroeck; Nadege Bondurand
Genetic interaction between Sox10 and Zfhx1b during enteric nervous system development.
Developmental biology 2010;341(2):416-28.
2009: Eve Seuntjens; Anjana Nityanandam; Amaya Miquelajauregui; Joke Debruyn; Agata Stryjewska; Sandra Goebbels; Klaus-Armin Nave; Danny Huylebroeck; Victor Tarabykin
Sip1 regulates sequential fate decisions by feedback signaling from postmitotic neurons to progenitors.
Nature neuroscience 2009;12(11):1373-80.
2009: Eve Seuntjens; Lieve Umans; An Zwijsen; Maurilio Sampaolesi; Catherine M Verfaillie; Danny Huylebroeck
Transforming Growth Factor type beta and Smad family signaling in stem cell function.
Cytokine & growth factor reviews 2009;20(5-6):449-58.
2009: Joanna Dzwonek; Olena Preobrazhenska; Silvia Cazzola; Andrea Conidi; Ann Schellens; Maarten van Dinther; Andrew Stubbs; Anke Klippel; Danny Huylebroeck; Peter ten Dijke; Kristin Verschueren
Smad3 is a key nonredundant mediator of transforming growth factor beta signaling in Nme mouse mammary epithelial cells.
Molecular cancer research : MCR 2009;7(8):1342-53.
2009: Liesbeth Vermeire; Abdelilah Ibrahimi; Thierry Voet; Lieve Umans; Kathleen Coddens; Annick Francis; Tom Van de Putte; Leo van Grunsven; An Zwijsen; Danny Huylebroeck; Luc Nelles
Essential validation of gene trap mouse ES cell lines: a test case with the gene Ttrap.
The International journal of developmental biology 2009;53(7):1045-51.
2008: Luk Cox; Lieve Umans; Frederique Cornelis; Danny Huylebroeck; An Zwijsen
A broken heart: a stretch too far: an overview of mouse models with mutations in stretch-sensor components.
International journal of cardiology 2008;131(1):33-44.
2008: Griet Verstappen; Leo van Grunsven; Christine Michiels; Tom Van de Putte; Jacob Souopgui; Jozef Van Damme; Eric Bellefroid; Joël Vandekerckhove; Danny Huylebroeck
Atypical Mowat-Wilson patient confirms the importance of the novel association between ZFHX1B/SIP1 and NuRD corepressor complex.
Human molecular genetics 2008;17(8):1175-83.
2008: Stephanie A Pangas; Xiaohui Li; Lieve Umans; An Zwijsen; Danny Huylebroeck; Carolina Gutierrez; Degang Wang; James F Martin; Soazik Jamin; Richard R Behringer; Elizabeth J Robertson; Martin M Matzuk
Conditional deletion of Smad1 and Smad5 in somatic cells of male and female gonads leads to metastatic tumor development in mice.
Molecular and cellular biology 2008;28(1):248-57.
2007: Camila V Esguerra; Luc Nelles; Liesbeth Vermeire; Abdelilah Ibrahimi; Alexander D Crawford; Rita Derua; Els Janssens; Etienne Waelkens; Peter Carmeliet; Desiré Collen; Danny Huylebroeck
Ttrap is an essential modulator of Smad3-dependent Nodal signaling during zebrafish gastrulation and left-right axis determination.
Development (Cambridge, England) 2007;134(24):4381-93.
2007: Sandy Sercu; Yves Poumay; F Herphelin; J Liekens; Lisette Beek; An Zwijsen; V Wessagowit; Danny Huylebroeck; J A McGrath; Joseph Merregaert
Functional redundancy of extracellular matrix protein 1 in epidermal differentiation.
The British journal of dermatology 2007;157(4):771-5.
2007: Amaya Miquelajauregui; Tom Van de Putte; Alexander Polyakov; Anjana Nityanandam; Sridhar Boppana; Eve Seuntjens; Anton Karabinos; Yujiro Higashi; Danny Huylebroeck; Victor Tarabykin
Smad-interacting protein-1 (Zfhx1b) acts upstream of Wnt signaling in the mouse hippocampus and controls its formation.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(31):12919-24.
2007: Tom Van de Putte; Annick Francis; Luc Nelles; Leo van Grunsven; Danny Huylebroeck
Neural crest-specific removal of Zfhx1b in mouse leads to a wide range of neurocristopathies reminiscent of Mowat-Wilson syndrome.
Human molecular genetics 2007;16(12):1423-36.
2007: Leo van Grunsven; Vincent Taelman; Carine Michiels; Griet Verstappen; Jacob Souopgui; Massimo Nichane; Emmanuelle Moens; Karin Opdecamp; Jessica Vanhomwegen; Sadia Kricha; Danny Huylebroeck; Eric J Bellefroid
XSip1 neuralizing activity involves the co-repressor CtBP and occurs through BMP dependent and independent mechanisms.
Developmental biology 2007;306(1):34-49.
2007: Lieve Umans; Luk Cox; Marc Tjwa; Virginie Bito; Liesbeth Vermeire; Kjell Laperre; Karin R Sipido; Lieve Moons; Danny Huylebroeck; An Zwijsen
Inactivation of Smad5 in endothelial cells and smooth muscle cells demonstrates that Smad5 is required for cardiac homeostasis.
The American journal of pathology 2007;170(5):1460-72.
2006: Hilde Peeters; Marianne L Voz; Kristin Verschueren; Bart De Cat; Hélène Pendeville; Bernard Thienpont; Ann Schellens; John W Belmont; Guido David; Wim J M Van De Ven; Jean-Pierre Fryns; Marc Gewillig; Danny Huylebroeck; Bernard Peers; koenraad devriendt
Sesn1 is a novel gene for left-right asymmetry and mediating nodal signaling.
Human molecular genetics 2006;15(22):3369-77.
2006: Erika A Bosman; Kirstie A Lawson; Joke Debruyn; Lisette Beek; Annick Francis; Luc Schoonjans; Danny Huylebroeck; An Zwijsen
Smad5 determines murine amnion fate through the control of bone morphogenetic protein expression and signalling levels.
Development (Cambridge, England) 2006;133(17):3399-409.
2006: Tomoya Miyoshi; Mitsuji Maruhashi; Tom Van de Putte; Hisato Kondoh; Danny Huylebroeck; Yujiro Higashi
Complementary expression pattern of Zfhx1 genes Sip1 and deltaEF1 in the mouse embryo and their genetic interaction revealed by compound mutants.
Developmental dynamics : an official publication of the American Association of Anatomists 2006;235(7):1941-52.
2006: Leo van Grunsven; Vincent Taelman; Carine Michiels; Karin Opdecamp; Danny Huylebroeck; Eric J Bellefroid
deltaEF1 and SIP1 are differentially expressed and have overlapping activities during Xenopus embryogenesis.
Developmental dynamics : an official publication of the American Association of Anatomists 2006;235(6):1491-500.
2005: Nathalie Verpoorten; Kristien Verhoeven; Stefan Weckx; An Jacobs; Sally Serneels; Jurgen Del-Favero; Chantal Ceuterick; Dirk R Van Bockstaele; Zwi N Berneman; Ludo Van Den Bosch; Wim Robberecht; Lucilla Nobbio; Angelo Schenone; Eric Dessaud; Odile deLapeyrière; Danny Huylebroeck; An Zwijsen; Peter De Jonghe; Vincent Timmerman
Synaptopodin and 4 novel genes identified in primary sensory neurons.
Molecular and cellular neurosciences 2005;30(3):316-25.
2005: Clara Collart; Kristin Verschueren; Amer Rana; Jim Smith; Danny Huylebroeck
The novel Smad-interacting protein Smicl regulates Chordin expression in the Xenopus embryo.
Development (Cambridge, England) 2005;132(20):4575-86.
2005: Mitsuji Maruhashi; Tom Van de Putte; Danny Huylebroeck; Hisato Kondoh; Yujiro Higashi
Involvement of SIP1 in positioning of somite boundaries in the mouse embryo.
Developmental dynamics : an official publication of the American Association of Anatomists 2005;234(2):332-8.
2005: Clara Collart; Jacques E Remacle; Silvia Barabino; Leo van Grunsven; Luc Nelles; Ann Schellens; Tom Van de Putte; Stefan Pype; Danny Huylebroeck; Kristin Verschueren
Smicl is a novel Smad interacting protein and cleavage and polyadenylation specificity factor associated protein.
Genes to cells : devoted to molecular & cellular mechanisms 2005;10(9):897-906.
2005: Vinciane Gaussin; Gregory E Morley; Luk Cox; An Zwijsen; Kendra M Vance; Lorin Emile; Yimin Tian; Jing Liu; Chull Hong; Dina Myers; Simon J Conway; Christophe Depre; Yuji Mishina; Richard R Behringer; Mark C Hanks; Michael D Schneider; Danny Huylebroeck; Glenn I Fishman; John B E Burch; Stephen F Vatner
Alk3/Bmpr1a receptor is required for development of the atrioventricular canal into valves and annulus fibrosus.
Circulation research 2005;97(3):219-26.
2005: Leo van Grunsven; Griet Verstappen; Danny Huylebroeck; Kristin Verschueren
Smads and chromatin modulation.
Cytokine & growth factor reviews 2005;16(4-5):495-512.
2005: Andrea Hoffmann; Olena Preobrazhenska; Claas Wodarczyk; Yvonne Medler; Andreas Winkel; Sandra Shahab; Danny Huylebroeck; Gerhard Gross; Kristin Verschueren
Transforming growth factor-beta-activated kinase-1 (TAK1), a MAP3K, interacts with Smad proteins and interferes with osteogenesis in murine mesenchymal progenitors.
The Journal of biological chemistry 2005;280(29):27271-83.
2004: Jan Hellemans; Olena Preobrazhenska; Andy Willaert; Philippe Debeer; Peter C M Verdonk; Teresa Costa; Koen Janssens; Björn Menten; Nadine Van Roy; Stefan Vermeulen; Ravi Savarirayan; Wim Van Hul; Filip Vanhoenacker; Danny Huylebroeck; Anne De Paepe; Jean-Marie Naeyaert; Jo Vandesompele; Frank Speleman; Kristin Verschueren; Paul J Coucke; Geert R Mortier
Loss-of-function mutations in LEMD3 result in osteopoikilosis, Buschke-Ollendorff syndrome and melorheostosis.
Nature genetics 2004;36(11):1213-8.
2004: Pierre Pirot; Leo van Grunsven; Jean-Christophe Marine; Danny Huylebroeck; Eric J Bellefroid
Direct regulation of the Nrarp gene promoter by the Notch signaling pathway.
Biochemical and biophysical research communications 2004;322(2):526-34.
2003: Kristien Verhoeven; Peter De Jonghe; Tom Van de Putte; Eva Nelis; An Zwijsen; Nathalie Verpoorten; Els De Vriendt; An Jacobs; Veerle Van Gerwen; Annick Francis; Chantal Ceuterick; Danny Huylebroeck; Vincent Timmerman
Slowed conduction and thin myelination of peripheral nerves associated with mutant rho Guanine-nucleotide exchange factor 10.
American journal of human genetics 2003;73(4):926-32.
2003: Luc Nelles; Tom Van de Putte; Leo van Grunsven; Danny Huylebroeck; Kristin Verschueren
Organization of the mouse Zfhx1b gene encoding the two-handed zinc finger repressor Smad-interacting protein-1.
Genomics 2003;82(4):460-9.
2003: Lieve Umans; Liesbeth Vermeire; Annick Francis; Hua Chang; Danny Huylebroeck; An Zwijsen
Generation of a floxed allele of Smad5 for cre-mediated conditional knockout in the mouse.
Genesis (New York, N.Y. : 2000) 2003;37(1):5-11.
2003: Irma Lemmens; Sven Eyckerman; Lennart Zabeau; Dominiek Catteeuw; Els Vertenten; Kristin Verschueren; Danny Huylebroeck; Joël Vandekerckhove; Jan Tavernier
Heteromeric MAPPIT: a novel strategy to study modification-dependent protein-protein interactions in mammalian cells.
Nucleic acids research 2003;31(14):e75.
2003: Leo van Grunsven; Carine Michiels; Tom Van de Putte; Luc Nelles; Gunther Wuytens; Kristin Verschueren; Danny Huylebroeck
Interaction between Smad-interacting protein-1 and the corepressor C-terminal binding protein is dispensable for transcriptional repression of E-cadherin.
The Journal of biological chemistry 2003;278(28):26135-45.
2003: An Zwijsen; Kristin Verschueren; Danny Huylebroeck
New intracellular components of bone morphogenetic protein/Smad signaling cascades.
FEBS letters 2003;546(1):133-9.
2003: Jessie Theuns; Jacques Remacle; Richard Killick; Ellen Corsmit; Krist'l Vennekens; Danny Huylebroeck; Marc Cruts; Christine Van Broeckhoven
Alzheimer-associated C allele of the promoter polymorphism -22C>T causes a critical neuron-specific decrease of presenilin 1 expression.
Human molecular genetics 2003;12(8):869-77.
2003: Tom Van de Putte; Mitsuji Maruhashi; Annick Francis; Luc Nelles; Hisato Kondoh; Danny Huylebroeck; Yujiro Higashi
Mice lacking ZFHX1B, the gene that codes for Smad-interacting protein-1, reveal a role for multiple neural crest cell defects in the etiology of Hirschsprung disease-mental retardation syndrome.
American journal of human genetics 2003;72(2):465-70.
2002: Vinciane Gaussin; Tom Van de Putte; Yuji Mishina; Mark C Hanks; An Zwijsen; Danny Huylebroeck; Richard R Behringer; Michael D Schneider
Endocardial cushion and myocardial defects after cardiac myocyte-specific conditional deletion of the bone morphogenetic protein receptor ALK3.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(5):2878-83.
2002: Yujiro Higashi; Mitsuji Maruhashi; Luc Nelles; Tom Van de Putte; Kristin Verschueren; Tomoya Miyoshi; Aki Yoshimoto; Hisato Kondoh; Danny Huylebroeck
Generation of the floxed allele of the SIP1 (Smad-interacting protein 1) gene for Cre-mediated conditional knockout in the mouse.
Genesis (New York, N.Y. : 2000) 2002;32(2):82-4.
2002: Catherine Papin; Leo van Grunsven; Kristin Verschueren; Danny Huylebroeck; Jim Smith
Dynamic regulation of Brachyury expression in the amphibian embryo by XSIP1.
Mechanisms of development 2002;111(1-2):37-46.
2002: Leo van Grunsven; Danny Huylebroeck; Kristin Verschueren
Complex Smad-dependent transcriptional responses in vertebrate development and human disease.
Critical reviews in eukaryotic gene expression 2002;12(2):101-18.
2001: Przemko Tylzanowski; Kristin Verschueren; Danny Huylebroeck; Frank P Luyten
Smad-interacting protein 1 is a repressor of liver/bone/kidney alkaline phosphatase transcription in bone morphogenetic protein-induced osteogenic differentiation of C2C12 cells.
The Journal of biological chemistry 2001;276(43):40001-7.
2001: Henrik Spåhr; Camilla O Samuelsen; Vera Baraznenok; I Ernest; Danny Huylebroeck; J E Remacle; Tore Samuelsson; Thomas Kieselbach; Steen Holmberg; Claes M Gustafsson
Analysis of Schizosaccharomyces pombe mediator reveals a set of essential subunits conserved between yeast and metazoan cells.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(21):11985-90.
2001: Mohammed Srahna; Jacques E Remacle; K Annamalai; Stefan Pype; Danny Huylebroeck; Marc Boogaerts; Peter Vandenberghe
NF-kappaB is involved in the regulation of CD154 (CD40 ligand) expression in primary human T cells.
Clinical and experimental immunology 2001;125(2):229-36.
2001: An Zwijsen; Leo van Grunsven; Erika A Bosman; Clara Collart; Luc Nelles; Lieve Umans; Tom Van de Putte; Gunther Wuytens; Danny Huylebroeck; Kristin Verschueren
Transforming growth factor beta signalling in vitro and in vivo: activin ligand-receptor interaction, Smad5 in vasculogenesis, and repression of target genes by the deltaEF1/ZEB-related SIP1 in the vertebrate embryo.
Molecular and cellular endocrinology 2001;180(1-2):13-24.
2001: J Comijn; Geert Berx; Petra Vermassen; Kristin Verschueren; Leo van Grunsven; Erik Bruyneel; Marc Mareel; Danny Huylebroeck; Frans van Roy
The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion.
Molecular cell 2001;7(6):1267-78.
2001: Tom Van de Putte; An Zwijsen; O Lonnoy; V Rybin; Miranda Cozijnsen; Annick Francis; Veerle Baekelandt; C A Kozak; M Zerial; Danny Huylebroeck
Mice with a homozygous gene trap vector insertion in mgcRacGAP die during pre-implantation development.
Mechanisms of development 2001;102(1-2):33-44.
2001: Leo van Grunsven; Ann Schellens; Danny Huylebroeck; Kristin Verschueren
SIP1 (Smad interacting protein 1) and deltaEF1 (delta-crystallin enhancer binding factor) are structurally similar transcriptional repressors.
The Journal of bone and joint surgery. American volume 2001;83-A Suppl 1(Pt 1):S40-7.
2000: Saskia Lippens; Mark Kockx; Michiel Knaapen; Laurent Mortier; Renata Polakowska; A Verheyen; Marjan Garmyn; An Zwijsen; Pierre Formstecher; Danny Huylebroeck; Peter Vandenabeele; Wim Declercq
Epidermal differentiation does not involve the pro-apoptotic executioner caspases, but is associated with caspase-14 induction and processing.
Cell death and differentiation 2000;7(12):1218-24.
2000: W Ju; A Hoffmann; Kristin Verschueren; Przemko Tylzanowski; Christian Kaps; G Gross; Danny Huylebroeck
The bone morphogenetic protein 2 signaling mediator Smad1 participates predominantly in osteogenic and not in chondrogenic differentiation in mesenchymal progenitors C3H10T1/2.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2000;15(10):1889-99.
2000: Doug W Eib; Tjadine M Holling; An Zwijsen; N Dewulf; E de Groot; AJ van den Eijnden-van Raaij; Danny Huylebroeck; Gerard J M Martens
Expression of the follistatin/EGF-containing transmembrane protein M7365 (tomoregulin-1) during mouse development.
Mechanisms of development 2000;97(1-2):167-71.
2000: An Zwijsen; Marga van Rooijen; Marie-José Goumans; N Dewulf; Erika A Bosman; Peter ten Dijke; Christine L Mummery; Danny Huylebroeck
Expression of the inhibitory Smad7 in early mouse development and upregulation during embryonic vasculogenesis.
Developmental dynamics : an official publication of the American Association of Anatomists 2000;218(4):663-70.
2000: Stefan Pype; Wim Declercq; A Ibrahimi; Carine Michiels; J G Van Rietschoten; N Dewulf; Mark de Boer; Peter Vandenabeele; Danny Huylebroeck; Jacques E Remacle
TTRAP, a novel protein that associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor-associated factors (TRAFs), and that inhibits nuclear factor-kappa B activation.
The Journal of biological chemistry 2000;275(24):18586-93.
2000: Leo van Grunsven; Catherine Papin; B Avalosse; Karin Opdecamp; Danny Huylebroeck; Jim Smith; Eric J Bellefroid
XSIP1, a Xenopus zinc finger/homeodomain encoding gene highly expressed during early neural development.
Mechanisms of development 2000;94(1-2):189-93.
2000: W Lerchner; Branko V Latinkic; Jacques E Remacle; Danny Huylebroeck; Jim Smith
Region-specific activation of the Xenopus brachyury promoter involves active repression in ectoderm and endoderm: a study using transgenic frog embryos.
Development (Cambridge, England) 2000;127(12):2729-39.
2000: H Chang; An Zwijsen; H Vogel; Danny Huylebroeck; M M Matzuk
Smad5 is essential for left-right asymmetry in mice.
Developmental biology 2000;219(1):71-8.
2000: A Haaijman; Elisabeth H Burger; SW Goei; Luc Nelles; Peter ten Dijke; Danny Huylebroeck; Antonius L J J Bronckers
Correlation between ALK-6 (BMPR-IB) distribution and responsiveness to osteogenic protein-1 (BMP-7) in embryonic mouse bone rudiments.
Growth factors (Chur, Switzerland) 2000;17(3):177-92.
1999: An Herreman; Dieter Hartmann; Willem ANNAERT; Paul Saftig; Katleen Craessaerts; Lutgarde Serneels; Lieve Umans; V Schrijvers; F Checler; hugo vanderstichele; Veerle Baekelandt; R Dressel; P Cupers; Danny Huylebroeck; An Zwijsen; Fred Van Leuven; Bart De Strooper
Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(21):11872-7.
1999: Geert Van Gassen; Chris De Jonghe; Stefan Pype; Wim van Criekinge; Ann Julliams; I Vanderhoeven; S Woodrow; Rudi Beyaert; Danny Huylebroeck; Christine Van Broeckhoven
Alzheimer's disease associated presenilin 1 interacts with HC5 and ZETA, subunits of the catalytic 20S proteasome.
Neurobiology of disease 1999;6(5):376-91.
1999: Jacques E Remacle; H Kraft; W Lerchner; Gunther Wuytens; Clara Collart; Kristin Verschueren; Jim Smith; Danny Huylebroeck
New mode of DNA binding of multi-zinc finger transcription factors: deltaEF1 family members bind with two hands to two target sites.
The EMBO journal 1999;18(18):5073-84.
1999: Kristin Verschueren; Danny Huylebroeck
Remarkable versatility of Smad proteins in the nucleus of transforming growth factor-beta activated cells.
Cytokine & growth factor reviews 1999;10(3-4):187-99.
1999: Marie-José Goumans; An Zwijsen; Marga van Rooijen; Danny Huylebroeck; Bernard A J Roelen; Christine L Mummery
Transforming growth factor-beta signalling in extraembryonic mesoderm is required for yolk sac vasculogenesis in mice.
Development (Cambridge, England) 1999;126(16):3473-83.
1999: Kristin Verschueren; Jacques E Remacle; Clara Collart; H Kraft; B S Baker; Przemko Tylzanowski; Luc Nelles; Gunther Wuytens; MT Su; Rolf Bodmer; Jim Smith; Danny Huylebroeck
SIP1, a novel zinc finger/homeodomain repressor, interacts with Smad proteins and binds to 5'-CACCT sequences in candidate target genes.
The Journal of biological chemistry 1999;274(29):20489-98.
1999: Gunther Wuytens; Kristin Verschueren; J P de Winter; N Gajendran; Lisette Beek; K Devos; F Bosman; P de Waele; Maria Andries; AJ van den Eijnden-van Raaij; Jim Smith; Danny Huylebroeck
Identification of two amino acids in activin A that are important for biological activity and binding to the activin type II receptors.
The Journal of biological chemistry 1999;274(14):9821-7.
1999: Hua Chang; Danny Huylebroeck; Kristin Verschueren; Q Guo; Martin M Matzuk; An Zwijsen
Smad5 knockout mice die at mid-gestation due to multiple embryonic and extraembryonic defects.
Development (Cambridge, England) 1999;126(8):1631-42.
1998: Jacques E Remacle; Rein Brys; Stefan Pype; Luc Nelles; Danny Huylebroeck
A novel expression cloning method to isolate mammalian transcription factors in Schizosaccharomyces pombe.
Nucleic acids research 1998;26(22):5223-4.
1998: Rein Brys; Luc Nelles; E van der Schueren; N Silvestre; Danny Huylebroeck; Jacques E Remacle
Identical cis-acting elements and related trans-acting factors control activity of nonviral promoter in Schizosaccharomyces pombe and mammalian cells.
DNA and cell biology 1998;17(4):349-58.
1998: X Peng; Jacques E Remacle; Ahmad Kasran; Danny Huylebroeck; Jan L Ceuppens
IL-12 up-regulates CD40 ligand (CD154) expression on human T cells.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(3):1166-72.
1997: Jacques E Remacle; G Albrecht; Rein Brys; Gerhard H Braus; Danny Huylebroeck
Three classes of mammalian transcription activation domain stimulate transcription in Schizosaccharomyces pombe.
The EMBO journal 1997;16(18):5722-9.
1997: G Meersseman; Kristin Verschueren; Luc Nelles; C Blumenstock; H Kraft; Gunther Wuytens; Jacques E Remacle; C A Kozak; Przemko Tylzanowski; Christof Niehrs; Danny Huylebroeck
The C-terminal domain of Mad-like signal transducers is sufficient for biological activity in the Xenopus embryo and transcriptional activation.
Mechanisms of development 1997;61(1-2):127-40.
1996: J P De Winter; C J De Vries; Tanja A E Van Achterberg; R F Ameerun; A Feijen; H Sugino; P De Waele; Danny Huylebroeck; Kristin Verschueren; A J Van Den Eijden-Van Raaij
Truncated activin type II receptors inhibit bioactivity by the formation of heteromeric complexes with activin type I. receptors.
Experimental cell research 1996;224(2):323-34.
1996: C J de Vries; J de Boer; Jos Joore; U Strähle; Tanja A E Van Achterberg; Danny Huylebroeck; Kristin Verschueren; Kohei Miyazono; AJ van den Eijnden-van Raaij; Danica Zivkovic
Active complex formation of type I and type II activin and TGF beta receptors in vivo as studied by overexpression in zebrafish embryos.
Mechanisms of development 1996;54(2):225-36.
1996: J P de Winter; Peter ten Dijke; C J de Vries; Tanja A E Van Achterberg; H Sugino; P de Waele; Danny Huylebroeck; Kristin Verschueren; AJ van den Eijnden-van Raaij
Follistatins neutralize activin bioactivity by inhibition of activin binding to its type II receptors.
Molecular and cellular endocrinology 1996;116(1):105-14.
1995: H Yamashita; Peter ten Dijke; Danny Huylebroeck; T K Sampath; Maria Andries; J C Smith; Carl-Henrik Heldin; Kohei Miyazono
Osteogenic protein-1 binds to activin type II receptors and induces certain activin-like effects.
The Journal of cell biology 1995;130(1):217-26.
1995: Kristin Verschueren; N Dewulf; Marie-José Goumans; O Lonnoy; A Feijen; Susanne Grimsby; K Vandi Spiegle; Peter ten Dijke; A Morén; Patrick Vanscheeuwijck; Carl-Henrik Heldin; Kohei Miyazono; C Mummery; J Van Den Eijnden-Van Raaij; Danny Huylebroeck
Expression of type I and type IB receptors for activin in midgestation mouse embryos suggests distinct functions in organogenesis.
Mechanisms of development 1995;52(1):109-23.
1995: N Dewulf; Kristin Verschueren; O Lonnoy; A Morén; Susanne Grimsby; K Vande Spiegle; Kohei Miyazono; Danny Huylebroeck; Peter ten Dijke
Distinct spatial and temporal expression patterns of two type I receptors for bone morphogenetic proteins during mouse embryogenesis.
Endocrinology 1995;136(6):2652-63.
1995: Bart De Strooper; John W M Creemers; Dieder Moechars; Danny Huylebroeck; Wim J M Van De Ven; Fred Van Leuven; Herman Van Den Berghe
Amyloid precursor protein is not processed by furin, PACE 4, PC1/3, PC2, PC4 and PC5/6 of the furin family of proprotein processing enzymes.
Biochimica et biophysica acta 1995;1246(2):185-8.
1993: John W M Creemers; Roland Siezen; Anton J M Roebroek; Torik A Y Ayoubi; Danny Huylebroeck; Wim J M Van De Ven
Modulation of furin-mediated proprotein processing activity by site-directed mutagenesis.
The Journal of biological chemistry 1993;268(29):21826-34.
1993: C M van der Kruijssen; A Feijen; Danny Huylebroeck; AJ van den Eijnden-van Raaij
Modulation of activin expression by type beta transforming growth factors.
Experimental cell research 1993;207(2):407-12.
1991: AJ van den Eijnden-van Raaij; Tanja A E Van Achterberg; C M van der Kruijssen; A H Piersma; Danny Huylebroeck; SW De Laat; C L Mummery
Differentiation of aggregated murine P19 embryonal carcinoma cells is induced by a novel visceral endoderm-specific FGF-like factor and inhibited by activin A.
Mechanisms of development 1991;33(2):157-65.
1990: R M Albano; S F Godsave; Danny Huylebroeck; K Van Nimmen; Harry V Isaacs; Jonathan M W Slack; Jim Smith
A mesoderm-inducing factor produced by WEHI-3 murine myelomonocytic leukemia cells is activin A.
Development (Cambridge, England) 1990;110(2):435-43.
1990: Danny Huylebroeck; K Van Nimmen; A Waheed; K von Figura; A Marmenout; L Fransen; P De Waele; J M Jaspar; P Franchimont; H Stunnenberg
Expression and processing of the activin-A/erythroid differentiation factor precursor: a member of the transforming growth factor-beta superfamily.
Molecular endocrinology (Baltimore, Md.) 1990;4(8):1153-65.
1990: AJ van den Eijnden-van Raaij; E J van Zoelent; K van Nimmen; C H Koster; Gerry Snoek; Antony Durston; Danny Huylebroeck
Activin-like factor from a Xenopus laevis cell line responsible for mesoderm induction.
Nature 1990;345(6277):732-4.
1990: Jim Smith; B M Price; K Van Nimmen; Danny Huylebroeck
Identification of a potent Xenopus mesoderm-inducing factor as a homologue of activin A.
Nature 1990;345(6277):729-31.