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Daniel Hwang

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Karuppiah Muthumani; Andrew Y Choo; Wei-Xing Zong; Muniswamy Madesh; Daniel S Hwang; Arumugam Premkumar; Khanh P Thieu; Joann Emmanuel; Sanjeev Kumar; Craig Thompson; David B Weiner
The HIV-1 Vpr and glucocorticoid receptor complex is a gain-of-function interaction that prevents the nuclear localization of PARP-1.
Karuppiah Muthumani; Andrew Y Choo; Daniel S Hwang; Nathanael S Dayes; Michael Chattergoon; Shanmugam Mayilvahanan; Khanh P Thieu; Peter T Buckley; Joann Emmanuel; Arumugam Premkumar; David B Weiner
HIV-1 Viral protein-r (Vpr) protects against lethal superantigen challenge while maintaining homeostatic T cell levels in vivo.
Karuppiah Muthumani; Andrew Y Choo; Daniel S Hwang; Arumugam Premkumar; Nathanael S Dayes; Crafford Harris; Douglas R Green; Scott Wadsworth; John Siekierka; David B Weiner
HIV-1 Nef-induced FasL induction and bystander killing requires p38 MAPK activation.

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All Publications

2006: Karuppiah Muthumani; Andrew Y Choo; Wei-Xing Zong; Muniswamy Madesh; Daniel S Hwang; Arumugam Premkumar; Khanh P Thieu; Joann Emmanuel; Sanjeev Kumar; Craig Thompson; David B Weiner
The HIV-1 Vpr and glucocorticoid receptor complex is a gain-of-function interaction that prevents the nuclear localization of PARP-1.
Nature cell biology 2006;8(2):170-9.
2005: Karuppiah Muthumani; Andrew Y Choo; Daniel S Hwang; Nathanael S Dayes; Michael Chattergoon; Shanmugam Mayilvahanan; Khanh P Thieu; Peter T Buckley; Joann Emmanuel; Arumugam Premkumar; David B Weiner
HIV-1 Viral protein-r (Vpr) protects against lethal superantigen challenge while maintaining homeostatic T cell levels in vivo.
Molecular therapy : the journal of the American Society of Gene Therapy 2005;12(5):910-21.
2005: Karuppiah Muthumani; Andrew Y Choo; Daniel S Hwang; Arumugam Premkumar; Nathanael S Dayes; Crafford Harris; Douglas R Green; Scott Wadsworth; John Siekierka; David B Weiner
HIV-1 Nef-induced FasL induction and bystander killing requires p38 MAPK activation.
Blood 2005;106(6):2059-68.
2005: Karuppiah Muthumani; Andrew Y Choo; Arumugam Premkumar; Daniel S Hwang; Khanh P Thieu; Brijal M Desai; David B Weiner
Human immunodeficiency virus type 1 (HIV-1) Vpr-regulated cell death: insights into mechanism.
Cell death and differentiation 2005;12 Suppl 1():962-70.
2005: Karuppiah Muthumani; Daniel S Hwang; Andrew Y Choo; Shanmugam Mayilvahanan; Nathanael S Dayes; Khanh P Thieu; David B Weiner
HIV-1 Vpr inhibits the maturation and activation of macrophages and dendritic cells in vitro.
International immunology 2005;17(2):103-16.
2004: Karuppiah Muthumani; Andrew Y Choo; Daniel S Hwang; Kenneth Ugen; David B Weiner
HIV-1 Vpr: enhancing sensitivity of tumors to apoptosis.
Current drug delivery 2004;1(4):335-44.
2004: Karuppiah Muthumani; Brijal M Desai; Daniel S Hwang; Andrew Y Choo; Dominick J Laddy; Khanh P Thieu; Rushil G Rao; David B Weiner
HIV-1 Vpr and anti-inflammatory activity.
DNA and cell biology 2004;23(4):239-47.
2004: Karuppiah Muthumani; Scott Wadsworth; Nathanael S Dayes; Daniel S Hwang; Andrew Y Choo; Harindra R Abeysinghe; John Siekierka; David B Weiner
Suppression of HIV-1 viral replication and cellular pathogenesis by a novel p38/JNK kinase inhibitor.
AIDS (London, England) 2004;18(5):739-48.
2003: Karuppiah Muthumani; Donghui Zhang; Nathanael S Dayes; Daniel S Hwang; Sandra A Calarota; Andrew Y Choo; Jean D Boyer; David B Weiner
Novel engineered HIV-1 East African Clade-A gp160 plasmid construct induces strong humoral and cell-mediated immune responses in vivo.
Virology 2003;314(1):134-46.
2003: Karuppiah Muthumani; Andrew Y Choo; Daniel S Hwang; Michael Chattergoon; Nathanael N Dayes; Donghui Zhang; Mark D Lee; Umaheswar Duvvuri; David B Weiner
Mechanism of HIV-1 viral protein R-induced apoptosis.
Biochemical and biophysical research communications 2003;304(3):583-92.
2003: Karuppiah Muthumani; Mark Bagarazzi; Dan Conway; Daniel S Hwang; Kelledy Manson; Richard B Ciccarelli; Zimmra Israel; David C Montefiori; Kenneth Ugen; Nancy Miller; Jong Kim; Jean Boyer; David B Weiner
A Gag-Pol/Env-Rev SIV239 DNA vaccine improves CD4 counts, and reduce viral loads after pathogenic intrarectal SIV(mac)251 challenge in rhesus Macaques.
Vaccine 2003;21(7-8):629-37.
2002: Joo-Sung Yang; Mathura P Ramanathan; Karuppiah Muthumani; Andrew Y Choo; Sung-Ha Jin; Qian-Chun Yu; Daniel S Hwang; Daniel K Choo; Mark D Lee; Kesen Dang; Waixing Tang; J Joseph Kim; David B Weiner
Induction of inflammation by West Nile virus capsid through the caspase-9 apoptotic pathway.
Emerging infectious diseases 2002;8(12):1379-84.
2002: Karuppiah Muthumani; Daniel S Hwang; Brijal M Desai; Donghui Zhang; Nathanael S Dayes; Douglas R Green; David B Weiner
HIV-1 Vpr induces apoptosis through caspase 9 in T cells and peripheral blood mononuclear cells.
The Journal of biological chemistry 2002;277(40):37820-31.
2002: Karuppiah Muthumani; Daniel S Hwang; Nathanael S Dayes; J Joseph Kim; David B Weiner
The HIV-1 accessory gene vpr can inhibit antigen-specific immune function.
DNA and cell biology 2002;21(9):689-95.
2002: Karuppiah Muthumani; Mark Bagarazzi; D Conway; Daniel S Hwang; Velpandi Ayyavoo; Donghui Zhang; Kelledy Manson; Jong Kim; Jean Boyer; David B Weiner
Inclusion of Vpr accessory gene in a plasmid vaccine cocktail markedly reduces Nef vaccine effectiveness in vivo resulting in CD4 cell loss and increased viral loads in rhesus macaques.
Journal of medical primatology 2002;31(4-5):179-85.
2002: Karuppiah Muthumani; Donghui Zhang; Daniel S Hwang; Sagar Kudchodkar; Nathanael S Dayes; Brijal M Desai; Afshan S Malik; Joo-Sung Yang; Michael Chattergoon; Henry C Maguire; David B Weiner
Adenovirus encoding HIV-1 Vpr activates caspase 9 and induces apoptotic cell death in both p53 positive and negative human tumor cell lines.
Oncogene 2002;21(30):4613-25.