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Eva Hyde

Research Profile

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Escherichia coli

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Amino Acid Sequences

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Publications

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Karthik Rajasekar; Sidra Tul Muntaha; Jeremy R H Tame; Sireesha Kommareddy; Gordon Morris; Christopher W Wharton; Christopher M Thomas; Scott A White; Eva I Hyde; David J Scott
Order and disorder in the domain organization of the plasmid partition protein KorB.
Mansooreh Jaberipour; Simon Oliver Vass; Christopher Guise; Jane I Grove; Richard J Knox; Longqin Hu; Eva I Hyde; Peter F Searle
Testing double mutants of the enzyme nitroreductase for enhanced cell sensitisation to prodrugs: effects of combining beneficial single mutations.
David Jarrom; Mansooreh Jaberipour; Christopher Guise; Simon Daff; Scott A White; Peter F Searle; Eva I Hyde
Steady-state and stopped-flow kinetic studies of three Escherichia coli NfsB mutants with enhanced activity for the prodrug CB1954.

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All Publications

2010: Karthik Rajasekar; Sidra Tul Muntaha; Jeremy R H Tame; Sireesha Kommareddy; Gordon Morris; Christopher W Wharton; Christopher M Thomas; Scott A White; Eva I Hyde; David J Scott
Order and disorder in the domain organization of the plasmid partition protein KorB.
The Journal of biological chemistry 2010;285(20):15440-9.
2010: Mansooreh Jaberipour; Simon Oliver Vass; Christopher Guise; Jane I Grove; Richard J Knox; Longqin Hu; Eva I Hyde; Peter F Searle
Testing double mutants of the enzyme nitroreductase for enhanced cell sensitisation to prodrugs: effects of combining beneficial single mutations.
Biochemical pharmacology 2010;79(2):102-11.
2009: David Jarrom; Mansooreh Jaberipour; Christopher Guise; Simon Daff; Scott A White; Peter F Searle; Eva I Hyde
Steady-state and stopped-flow kinetic studies of three Escherichia coli NfsB mutants with enhanced activity for the prodrug CB1954.
Biochemistry 2009;48(32):7665-72.
2009: Simon Oliver Vass; D Jarrom; William Wilson; Eva I Hyde; Peter F Searle
E. coli NfsA: an alternative nitroreductase for prodrug activation gene therapy in combination with CB1954.
British journal of cancer 2009;100(12):1903-11.
2008: Lewis E H Bingle; Karthik V Rajasekar; Sidra tul Muntaha; Vinod Nadella; Eva I Hyde; Christopher M Thomas
A single aromatic residue in transcriptional repressor protein KorA is critical for cooperativity with its co-regulator KorB.
Molecular microbiology 2008;70(6):1502-14.
2007: K John Smith; George S Baillie; Eva I Hyde; Xiang Li; Thomas M Houslay; Angela McCahill; Allan J Dunlop; Graeme B Bolger; Enno Klussmann; David R Adams; Miles D Houslay
1H NMR structural and functional characterisation of a cAMP-specific phosphodiesterase-4D5 (PDE4D5) N-terminal region peptide that disrupts PDE4D5 interaction with the signalling scaffold proteins, beta-arrestin and RACK1.
Cellular signalling 2007;19(12):2612-24.
2007: Paul R Race; Andrew L Lovering; Scott A White; Jane I Grove; Peter F Searle; Christopher W Wrighton; Eva I Hyde
Kinetic and structural characterisation of Escherichia coli nitroreductase mutants showing improved efficacy for the prodrug substrate CB1954.
Journal of molecular biology 2007;368(2):481-92.
2007: Christopher Guise; Jane I Grove; Eva I Hyde; Peter F Searle
Direct positive selection for improved nitroreductase variants using SOS triggering of bacteriophage lambda lytic cycle.
Gene therapy 2007;14(8):690-8.
2006: K V Rajasekar; L E H Bingle; C M Thomas; Eva I Hyde
1H, 13C and 15N assignments of the KorA global transcriptional repressor protein from the low copy number IncP-1 plasmid, RK2.
Journal of biomolecular NMR 2006;36 Suppl 1():71.
2005: Paul R Race; Andrew L Lovering; Richard M Green; Abdelmijd Ossor; Scott A White; Peter F Searle; Christopher J Wrighton; Eva I Hyde
Structural and mechanistic studies of Escherichia coli nitroreductase with the antibiotic nitrofurazone. Reversed binding orientations in different redox states of the enzyme.
The Journal of biological chemistry 2005;280(14):13256-64.
2004: Peter F Searle; Ming-Jen Chen; Longqin Hu; Paul R Race; Andrew L Lovering; Jane I Grove; Christopher Guise; Mansooreh Jaberipour; Nicholas James; Vivien Mautner; Lawrence S Young; David J Kerr; Andrew Mountain; Scott A White; Eva I Hyde
Nitroreductase: a prodrug-activating enzyme for cancer gene therapy.
Clinical and experimental pharmacology & physiology 2004;31(11):811-6.
2004: David C Grainger; Tamara A Belyaeva; David Lee; Eva I Hyde; Stephen J W Busby
Transcription activation at the Escherichia coli melAB promoter: interactions of MelR with the C-terminal domain of the RNA polymerase alpha subunit.
Molecular microbiology 2004;51(5):1311-20.
2004: David C Grainger; Christine L Webster; Tamara A Belyaeva; Eva I Hyde; Stephen J W Busby
Transcription activation at the Escherichia coli melAB promoter: interactions of MelR with its DNA target site and with domain 4 of the RNA polymerase sigma subunit.
Molecular microbiology 2004;51(5):1297-309.
2003: Longqin Hu; Chengzhi Yu; Yongying Jiang; Jiye Han; Zhuorong Li; Patrick Browne; Paul R Race; Richard J Knox; Peter F Searle; Eva I Hyde
Nitroaryl phosphoramides as novel prodrugs for E. coli nitroreductase activation in enzyme prodrug therapy.
Journal of medicinal chemistry 2003;46(23):4818-21.
2003: Jane I Grove; Andrew L Lovering; Christopher Guise; Paul R Race; Christopher J Wrighton; Scott A White; Eva I Hyde; Peter F Searle
Generation of Escherichia coli nitroreductase mutants conferring improved cell sensitization to the prodrug CB1954.
Cancer research 2003;63(17):5532-7.
2003: David C Grainger; Tamara A Belyaeva; David Lee; Eva I Hyde; Stephen J W Busby
Binding of the Escherichia coli MelR protein to the melAB promoter: orientation of MelR subunits and investigation of MelR-DNA contacts.
Molecular microbiology 2003;48(2):335-48.
2002: Mahesh Jaseja; Mark Jeeves; Eva I Hyde
Trp repressor-operator binding: NMR and electrophoretic mobility shift studies of the effect of DNA sequence and corepressor binding on two Trp repressor-operator complexes.
Biochemistry 2002;41(50):14866-78.
2002: Pampa Ray; K John Smith; Rosemary A Parslow; Ray Dixon; Eva I Hyde
Secondary structure and DNA binding by the C-terminal domain of the transcriptional activator NifA from Klebsiella pneumoniae.
Nucleic acids research 2002;30(18):3972-80.
2002: Victoria J Howard; Tamara A Belyaeva; Stephen J W Busby; Eva I Hyde
DNA binding of the transcription activator protein MelR from Escherichia coli and its C-terminal domain.
Nucleic acids research 2002;30(12):2692-700.
2001: Joseph T Wade; Tamara A Belyaeva; Eva I Hyde; Stephen J W Busby
A simple mechanism for co-dependence on two activators at an Escherichia coli promoter.
The EMBO journal 2001;20(24):7160-7.
2001: Andrew L Lovering; Eva I Hyde; Peter F Searle; Scott A White
The structure of Escherichia coli nitroreductase complexed with nicotinic acid: three crystal forms at 1.7 A, 1.8 A and 2.4 A resolution.
Journal of molecular biology 2001;309(1):203-13.
2000: Joseph T Wade; Tamara A Belyaeva; Eva I Hyde; Stephen J W Busby
Repression of the Escherichia coli melR promoter by MelR: evidence that efficient repression requires the formation of a repression loop.
Molecular microbiology 2000;36(1):223-9.
2000: Tamara A Belyaeva; Joseph T Wade; Christine L Webster; Virginia J Howard; M S Thomas; Eva I Hyde; Stephen J W Busby
Transcription activation at the Escherichia coli melAB promoter: the role of MelR and the cyclic AMP receptor protein.
Molecular microbiology 2000;36(1):211-22.
1999: Mark Jeeves; P D Evans; Rosemary A Parslow; Mahesh Jaseja; Eva I Hyde
Studies of the Escherichia coli Trp repressor binding to its five operators and to variant operator sequences.
European journal of biochemistry / FEBS 1999;265(3):919-28.
1999: S Missaillidis; Mahesh Jaseja; P Ray; RS Chittock; C W Wharton; A F Drake; Martin Buck; Eva I Hyde
Secondary structure of the C-terminal DNA-binding domain of the transcriptional activator NifA from Klebsiella pneumoniae: spectroscopic analyses.
Archives of biochemistry and biophysics 1999;361(2):173-82.
1997: S J Bourgerie; C M Michán; M S Thomas; Stephen J W Busby; Eva I Hyde
DNA binding and DNA bending by the MelR transcription activator protein from Escherichia coli.
Nucleic acids research 1997;25(9):1685-93.
1996: P D Evans; M Jaseja; Mark Jeeves; Eva I Hyde
NMR studies of the Escherichia coli Trp repressor.trpRs operator complex.
European journal of biochemistry / FEBS 1996;242(3):567-75.
1996: K J Smith; M Jaseja; X Lu; J A Williams; Eva I Hyde; Ian P Trayer
Three-dimensional structure of the RGD-containing snake toxin albolabrin in solution, based on 1H NMR spectroscopy and simulated annealing calculations.
International journal of peptide and protein research 1996;48(3):220-8.
1995: C M Michán; Stephen J W Busby; Eva I Hyde
The Escherichia coli MelR transcription activator: production of a stable fragment containing the DNA-binding domain.
Nucleic acids research 1995;23(9):1518-23.
1994: M Jaseja; X Lu; J A Williams; Michael J Sutcliffe; V V Kakkar; Rosemary A Parslow; Eva I Hyde
1H-NMR assignments and secondary structure of dendroaspin, an RGD-containing glycoprotein IIb-IIIa (alpha IIb-beta 3) antagonist with a neurotoxin fold.
European journal of biochemistry / FEBS 1994;226(3):861-8.
1994: Michael J Sutcliffe; M Jaseja; Eva I Hyde; X Lu; J A Williams
Three-dimensional structure of the RGD-containing neurotoxin homologue dendroaspin.
Nature structural biology 1994;1(11):802-7.
1993: M Jaseja; K J Smith; X Lu; J A Williams; HR Trayer; Ian P Trayer; Eva I Hyde
1H-NMR studies and secondary structure of the RGD-containing snake toxin, albolabrin.
European journal of biochemistry / FEBS 1993;218(3):853-60.
1991: Eva I Hyde; V Ramesh; R Frederick; Gordon Roberts
NMR studies of the activation of the Escherichia coli trp repressor.
European journal of biochemistry / FEBS 1991;201(3):569-79.
1989: Eva I Hyde; V Ramesh; Gordon Roberts; Cheryl H Arrowsmith; L Treat-Clemons; B Klaic; O Jardetzky
NMR studies of the Escherichia coli trp aporepressor. Sequence-specific assignment of the aromatic proton resonances.
European journal of biochemistry / FEBS 1989;183(3):545-53.